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Other specified/unspecified diseases of inner ear

DOID EFO Endpoint Browser PheWeb

H8_INNERNAS

inner ear disease: A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems. [database_cross_reference: NCIT:C27166]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

177

4. Check minimum number of events

None

177

5. Include endpoints

None

177

6. Filter based on genotype QC (FinnGen only)

177

Control definitions (FinnGen only)

Control exclude
H8_INNER

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1376 700 666
Only index persons 1255 656 599
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 68.30 67.86 68.62
Only index persons 67.10 67.22 66.97

-FinnGen-

Key figures

All Female Male
Number of individuals 177 82 95
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 64.64 58.33 70.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
158
Matched controls
1580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.9
ICD-10 Finland
Disease of inner ear, unspecified
+∞
164.8
128
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
15.9
47.7
90
121
H83.8
ICD-10 Finland
Other specified diseases of inner ear
+∞
33.5
31
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
17.7
30.9
50
40
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
11.7
27.6
55
69
R5599
NOMESCO Finland
Other rehabilitation service
34.1
27.2
35
13
DFF00
NOMESCO Finland
Pure tone audiometry
11.0
24.2
49
62
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
10.5
21.4
44
56
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
7.0
18.7
51
101
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
14.7
14.5
24
19
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.6
13.6
54
160
N07CA01
ATC
betahistine; oral
6.8
13.1
34
61
R1260
NOMESCO Finland
Evaluation of communicative skills
23.6
12.3
17
8
TDA90
NOMESCO Finland
Removal wax from ear
32.9
11.9
15
5
RD211
NOMESCO Finland
NA
11.9
11.1
20
19
DFF15
NOMESCO Finland
Speech audiometry
8.8
10.8
23
30
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
9.3
10.7
22
27
UDC00
NOMESCO Finland
Ear microscopy
6.5
9.4
24
42
R5140
NOMESCO Finland
Monitoring the use of the aid
4.8
8.9
30
73
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
11.0
8.8
16
16
H81.0
ICD-10 Finland
Ménière disease
83.8
7.5
8
*
Z00.0
ICD-10 Finland
General medical examination
3.2
7.3
43
167
R5120
NOMESCO Finland
Preparation of an aid
10.8
7.2
13
13
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
10.8
7.2
13
13
Z71.8
ICD-10 Finland
Other specified counselling
2.9
7.0
46
194
H13
ICPC
Plugged feeling ear
3.1
6.9
39
149
WNF00
NOMESCO Finland
Infection source and contact determination
41.9
6.8
8
*
SAA01
NOMESCO Finland
Simple examination of mouth
2.4
6.6
103
689
R42
ICD-10 Finland
Dizziness and giddiness
2.8
6.5
46
202
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.9
6.4
42
175
XCD10
NOMESCO Finland
Electrophysiological examination of eye
8.2
6.3
13
17
DAX08
NOMESCO Finland
Fitting of hearing aid
5.8
6.0
16
30
H91.9
ICD-10 Finland
Hearing loss, unspecified
6.3
6.0
15
26

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
90
569
2.18
6.08
9.1
8.9
0.0
0.0
e9/l
0.53
73
468
134
1049
2.14
4.56
20.7
18.3
13.8
13.8
%
0.28
128
1027
47
262
2.08
4.15
3.9
2.8
0.9
0.7
ug/l
0.51
25
172
22
94
2.53
3.58
3.1
4.2
—
0.6
—
0
23
84
617
1.69
2.93
5.0
5.3
56.3
58.4
%
0.72
77
576
82
601
1.68
2.87
4.6
5.3
0.7
0.6
%
0.87
74
554
83
611
1.67
2.85
4.8
5.3
2.9
2.8
%
0.18
76
563
5
6
8.53
2.76
1.8
1.2
—
—
—
0
0
83
616
1.65
2.74
5.2
5.6
8.6
8.7
%
0.14
76
575
84
627
1.65
2.70
4.9
5.5
28.9
26.5
%
0.90
77
580
21
103
2.18
2.54
3.1
4.4
—
0.1
—
0
32
55
375
1.68
2.47
4.5
3.1
0.6
0.4
e6/l
0.25
36
282
54
369
1.67
2.40
4.5
3.0
—
—
—
0
0
43
278
1.72
2.33
2.6
2.9
556.8
561.7
mosm/kgh2o
0.05
36
240
60
425
1.62
2.30
4.3
3.2
60.2
179.4
e6/l
0.36
39
333
44
290
1.69
2.22
2.8
2.7
3.4
4.6
e6/l
0.64
34
264
84
649
1.56
2.22
4.5
5.2
0.6
0.6
e9/l
0.45
68
569
85
659
1.56
2.21
4.5
5.4
2.1
1.8
e9/l
0.45
78
592
84
650
1.56
2.20
4.6
5.2
0.0
0.0
e9/l
0.92
68
571
0
57
0.00
2.09
0.0
1.6
—
—
—
0
0
29
172
1.82
2.09
1.4
1.3
—
—
—
0
0
5
10
5.11
2.08
1.4
1.7
7.3
9.3
mmol/l
—
5
10
156
1409
1.90
2.06
23.9
22.1
245.8
244.4
e9/l
0.10
151
1368
156
1410
1.90
2.04
23.8
22.1
6.9
6.8
e9/l
0.26
145
1362
156
1410
1.90
2.04
23.8
22.1
4.4
4.4
e12/l
0.37
145
1363
85
669
1.52
2.01
5.0
5.5
0.2
0.2
e9/l
0.57
78
593
70
533
1.52
1.91
2.6
2.1
—
—
—
0
0
94
766
1.48
1.82
9.5
8.5
4.1
4.1
e9/l
0.09
77
670
27
166
1.74
1.74
1.2
1.3
—
—
—
0
0
5
13
3.92
1.72
1.2
1.6
—
—
—
0
0
144
1291
1.62
1.71
17.0
15.3
25.7
25.1
mg/l
0.06
131
1049
147
1327
1.64
1.67
18.7
18.0
4.0
4.0
mmol/l
0.39
141
1290
23
140
1.74
1.54
2.4
2.4
73.5
155.5
ug/g
1.05
17
112
63
489
1.45
1.51
4.6
3.7
304.5
81.0
e6/l
0.45
41
356
137
1228
1.51
1.49
4.6
4.8
6.0
6.0
mmol/l
0.02
116
1104
105
896
1.42
1.48
4.3
4.1
—
—
—
0
0
147
1340
1.57
1.45
13.9
14.2
—
—
—
0
0
113
980
1.42
1.43
3.8
4.0
12.5
12.6
mm/h
0.01
107
896
141
1275
1.52
1.43
5.0
5.1
2.7
2.7
mmol/l
0.37
120
1151
40
287
1.51
1.41
3.8
4.8
—
—
—
0
0
6
23
2.66
1.38
2.3
3.0
32.2
19.0
u/ml
—
6
23
5
17
2.99
1.37
1.6
1.2
—
—
—
0
0
5
17
2.99
1.37
1.6
1.6
57.4
57.2
%
—
5
17
134
1206
1.46
1.33
3.9
4.1
1.4
1.3
mmol/l
1.57
115
1079
16
92
1.81
1.30
1.5
1.5
—
—
—
0
0
137
1241
1.46
1.29
4.4
4.6
1.4
1.4
mmol/l
0.83
118
1119
9
44
2.10
1.29
2.8
1.5
—
—
—
0
0
9
44
2.10
1.29
2.1
3.3
—
—
—
0
0
106
923
1.37
1.23
4.4
3.9
14.4
14.8
pmol/l
1.00
101
830
5
19
2.68
1.22
2.4
1.5
35.6
32.6
pg
—
5
19
35
252
1.48
1.21
5.3
3.5
220.1
369.7
ng/l
0.33
29
213
68
564
1.33
1.04
2.7
2.7
181.3
112.7
ug/l
0.46
58
514
45
351
1.38
1.02
1.8
1.5
20.4
21.1
nmol/l
0.10
36
290
43
333
1.38
1.01
4.3
3.8
85.9
87.1
%
0.10
43
322
25
175
1.50
1.00
4.5
5.5
104.7
104.4
mmol/l
0.08
25
170
0
29
0.00
0.98
0.0
1.3
—
—
—
0
0
0
30
0.00
0.98
0.0
1.7
—
5.3
—
0
12
31
409
0.71
0.96
4.5
4.2
—
—
—
0
0
66
551
1.32
0.96
2.1
2.0
92.8
94.9
pmol/l
0.15
30
274
24
170
1.48
0.91
1.6
1.4
—
—
—
0
0
6
29
2.11
0.90
2.5
3.5
—
—
—
0
0
114
1030
1.30
0.89
8.1
7.3
74.3
78.4
u/l
0.48
106
952
56
461
1.31
0.89
4.4
2.9
2.4
2.3
mmol/l
0.55
45
395
17
112
1.57
0.88
3.2
3.8
1.2
1.2
mmol/l
0.43
17
102
8
140
0.55
0.87
1.1
1.4
—
—
—
0
0
10
162
0.59
0.81
1.4
1.5
—
—
—
0
0
7
125
0.54
0.81
6.9
4.6
—
—
—
0
0
0
26
0.00
0.79
0.0
1.7
—
19371.2
—
0
19
68
583
1.27
0.78
3.7
4.3
34.6
35.3
g/l
0.48
63
545
50
413
1.29
0.77
2.3
3.0
—
—
—
0
0
125
1157
1.27
0.73
5.6
4.7
2.1
1.9
mu/l
0.63
109
1025
5
25
2.03
0.73
1.6
2.8
—
—
—
0
0
9
57
1.61
0.72
3.3
2.8
—
—
—
0
0
48
399
1.28
0.70
4.1
3.9
7.4
7.4
ph
—
10
79
127
1181
1.27
0.69
6.3
6.4
41.5
40.9
mmol/mol
0.31
117
1086
18
128
1.45
0.69
1.5
3.9
2.1
1.6
mmol/l
0.11
11
101
32
253
1.32
0.67
2.4
2.7
2.4
2.5
mmol/l
0.88
20
223
11
70
1.61
0.67
4.5
15.5
—
—
—
0
0
5
28
1.81
0.66
1.0
1.3
—
—
—
0
0
18
130
1.43
0.64
1.6
3.9
5.7
5.8
kpa
0.03
18
122
0
22
0.00
0.59
0.0
1.7
—
—
—
0
0
26
205
1.31
0.56
2.1
2.2
—
—
—
0
0
11
74
1.52
0.55
1.4
1.2
—
—
—
0
0
6
96
0.61
0.54
3.5
3.2
4.8
5.1
kpa
—
6
87
18
136
1.36
0.51
1.6
4.0
—
—
—
0
0
21
163
1.33
0.51
3.0
4.1
1.9
50.4
ug/l
0.61
14
135
7
46
1.54
0.49
1.3
2.1
22.3
21.3
s
—
7
41
120
1131
1.19
0.47
20.0
16.3
40.0
39.3
%
0.51
100
800
15
112
1.37
0.46
1.4
3.0
4.1
4.4
kpa
0.28
15
104
54
476
1.19
0.46
7.3
5.1
29.2
2.1
ug/l
0.67
43
416
30
249
1.25
0.45
1.2
1.4
2.9
2.6
g/l
0.50
15
156
38
325
1.22
0.44
3.1
2.9
8676.0
7375.2
umol/l
0.05
31
272
35
297
1.22
0.44
1.8
1.7
0.9
1.2
mg/l
0.74
22
222
6
94
0.63
0.43
3.3
3.3
—
7.4
—
0
8
6
95
0.62
0.43
1.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
3.4
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
2.0
2.6
1.4
1.8
mg/l
—
5
29
31
363
0.82
0.40
4.9
3.8
0.0
0.0
estimate
0.50
18
122
31
263
1.22
0.39
1.2
1.2
0.6
2.1
u/ml
1.13
13
72
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
39
339
1.19
0.39
9.6
6.1
—
—
—
0
0
46
406
1.18
0.39
5.5
4.2
—
—
—
0
0
5
36
1.40
0.38
1.0
1.2
—
—
—
0
0
15
116
1.32
0.38
2.3
2.3
65.7
69.7
e9/l
—
10
91
62
562
1.16
0.38
11.3
9.2
1.3
1.3
inr
0.22
25
167
49
438
1.16
0.35
4.9
4.9
—
—
—
0
0
86
919
0.88
0.35
4.8
4.0
—
—
—
0
0
10
132
0.74
0.33
4.1
2.2
3.5
5.5
ug/l
—
10
116
62
568
1.14
0.32
4.0
4.0
25.9
48.4
ng/l
1.36
48
405
8
108
0.73
0.30
4.3
3.0
—
—
—
0
0
14
112
1.27
0.29
2.7
2.1
66.1
65.8
g/l
0.07
14
97
42
377
1.15
0.29
3.5
3.5
—
—
—
0
0
10
76
1.33
0.29
1.0
1.2
—
—
—
0
0
6
85
0.70
0.24
1.2
1.3
—
—
—
0
0
13
106
1.24
0.24
4.6
7.8
—
—
—
0
0
12
98
1.24
0.22
1.7
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
1.8
—
0
10
0
12
0.00
0.21
0.0
1.7
—
740.5
—
0
6
39
357
1.12
0.20
1.9
2.0
2.5
3.0
mg/l
1.14
31
308
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
19
167
1.15
0.17
4.8
8.7
11.0
11.4
kpa
0.18
19
161
19
167
1.15
0.17
4.8
8.7
5.3
5.1
kpa
0.64
19
160
8
70
1.15
0.16
1.6
2.8
0.7
1.2
%
—
8
70
11
92
1.21
0.16
1.1
1.1
—
—
—
0
0
12
102
1.19
0.15
1.8
1.6
—
—
—
0
0
31
285
1.11
0.15
3.6
3.6
—
—
—
0
0
9
80
1.13
0.15
1.6
2.4
—
—
—
0
0
54
511
1.08
0.15
3.4
3.5
—
—
—
0
0
8
97
0.82
0.14
1.3
1.4
—
—
—
0
0
45
424
1.08
0.14
2.5
2.4
—
—
—
0
0
11
126
0.86
0.11
1.5
2.2
0.2
0.2
g/l
0.09
11
113
67
645
1.06
0.11
5.7
5.2
0.0
0.0
estimate
0.50
18
128
25
231
1.10
0.11
1.8
2.3
13.6
13.3
umol/l
0.06
25
204
34
322
1.07
0.09
1.3
1.4
—
—
—
0
0
5
60
0.83
0.08
3.4
1.7
2.9
5.5
ug/l
—
5
51
6
73
0.82
0.08
7.3
5.0
25.0
24.5
mmol/l
—
6
73
11
122
0.90
0.07
1.0
1.4
—
—
—
0
0
9
101
0.89
0.06
3.4
8.5
—
—
—
0
0
9
100
0.89
0.06
2.8
2.6
—
—
—
0
0
10
111
0.89
0.06
4.5
3.6
—
—
—
0
0
22
209
1.06
0.04
1.3
1.2
0.7
15.7
u/ml
—
7
80
32
331
0.96
0.04
1.9
1.6
1.3
1.3
mmol/l
0.00
23
278
21
220
0.95
0.04
1.2
1.2
17.6
40.9
iu/ml
—
5
68
18
171
1.06
0.03
1.7
1.5
—
—
—
0
0
67
659
1.03
0.03
4.1
3.8
0.0
0.0
estimate
0.00
18
125
40
410
0.97
0.03
4.1
3.9
8.9
8.4
mg/mmol
0.03
24
265
19
198
0.95
0.02
22.5
27.8
1.0
1.5
inr
—
5
25
20
196
1.02
0.00
1.5
1.6
—
—
—
0
0
29
294
0.98
0.00
4.1
3.9
1.0
1.0
kg/l
—
5
49
65
649
1.00
0.00
4.2
3.7
0.0
0.0
estimate
0.00
17
131
15
147
1.02
0.00
1.5
1.3
—
—
—
0
0
38
383
0.99
0.00
3.4
3.0
58.6
215.3
mg/l
0.48
30
259
39
395
0.98
0.00
3.2
2.9
7.5
7.9
mmol/l
0.23
28
326
42
422
0.99
0.00
2.5
3.2
—
—
—
0
0
12
118
1.02
0.00
1.4
1.4
—
—
—
0
0
7
76
0.92
0.00
3.0
3.9
—
—
—
0
0
5
53
0.94
0.00
4.6
4.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
12.7
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
4.3
—
57.0
—
0
6
0
7
0.00
0.00
0.0
5.1
—
—
—
0
0
0
5
0.00
0.00
0.0
18.2
—
1165.8
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
18.0
—
570.4
—
0
5
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
1.2
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
10.5
—
0.6
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
4.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
118.5
—
0
6
0
6
0.00
0.00
0.0
1.3
—
1.2
—
0
6
0
6
0.00
0.00
0.0
2.2
—
2107.5
—
0
6
0
6
0.00
0.00
0.0
1.8
—
16.1
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
125.4
—
0
7
0
5
0.00
0.00
0.0
1.4
—
34.6
—
0
5
5
49
1.02
0.00
1.0
1.1
—
—
—
0
0
8
79
1.01
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
6.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint H8_INNERNAS and mortality.

Females

Parameter HR [95% CI] p-value
H8_INNERNAS 0.994 [0.83, 1.19] 0.949
Birth year 0.992 [0.98, 1.0] 0.078

During the follow-up period (1.1.1998 — 31.12.2019), 195 out of 647 females with H8_INNERNAS died.

Males

Parameter HR [95% CI] p-value
H8_INNERNAS 0.865 [0.72, 1.03] 0.111
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 621 males with H8_INNERNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_INNERNAS.

N-year risk Females Males
1 0.068% 0.162%
5 0.537% 0.875%
10 1.345% 2.277%
15 2.663% 4.493%
20 4.46% 7.531%

Relationships between endpoints

↥

Index endpoint: H8_INNERNAS – Other specified/unspecified diseases of inner ear

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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