inner ear disease: A non-neoplastic or neoplastic disorder affecting the inner ear. Causes are inner ear infections, head injuries, and neoplasms (e.g., acoustic schwannoma). Symptoms include dizziness, imbalance, nausea, and vision problems. [database_cross_reference: NCIT:C27166]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
177 |
4. Check minimum number of eventsNone |
177 |
5. Include endpointsNone |
177 |
6. Filter based on genotype QC (FinnGen only) |
177 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to Other specified/unspecified diseases of inner ear based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 1376 | 700 | 666 |
Only index persons | 1255 | 656 | 599 |
Unadjusted period prevalence (%) | |||
Whole population | 0.02 | 0.02 | 0.02 |
Only index persons | 0.02 | 0.02 | 0.02 |
Median age at first event (years) | |||
Whole population | 68.30 | 67.86 | 68.62 |
Only index persons | 67.10 | 67.22 | 66.97 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 177 | 82 | 95 |
Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
Median age at first event (years) | 64.64 | 58.33 | 70.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 158
- Matched controls
- 1580
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint H8_INNERNAS and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H8_INNERNAS | 0.994 [0.83, 1.19] | 0.949 |
Birth year | 0.992 [0.98, 1.0] | 0.078 |
During the follow-up period (1.1.1998 — 31.12.2019), 195 out of 647 females with H8_INNERNAS died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H8_INNERNAS | 0.865 [0.72, 1.03] | 0.111 |
Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 621 males with H8_INNERNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_INNERNAS.N-year risk | Females | Males |
---|---|---|
1 | 0.068% | 0.162% |
5 | 0.537% | 0.875% |
10 | 1.345% | 2.277% |
15 | 2.663% | 4.493% |
20 | 4.46% | 7.531% |
Relationships between endpoints
↥Index endpoint: H8_INNERNAS – Other specified/unspecified diseases of inner ear
GWS hits: -