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Other specified/unspecified diseases of inner ear

DOID EFO Endpoint Browser PheWeb

H8_INNERNAS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

185

4. Check minimum number of events

None

185

5. Include endpoints

None

185

6. Filter based on genotype QC (FinnGen only)

178

Control definitions (FinnGen only)

Control exclude
H8_INNER

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1376 700 666
Only index persons 1255 656 599
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 68.30 67.86 68.62
Only index persons 67.10 67.22 66.97

-FinnGen-

Key figures

All Female Male
Number of individuals 178 84 94
Unadjusted period prevalence (%) 0.04 0.03 0.04
Median age at first event (years) 64.51 58.33 70.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
185
Matched controls
1850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.9
ICD-10 Finland
Disease of inner ear, unspecified
+∞
189.8
148
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
18.5
93.6
109
133
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
13.9
60.6
68
74
R5599
NOMESCO Finland
Other rehabilitation service
27.7
59.5
43
20
Z97.4
ICD-10 Finland
Presence of external hearing-aid
15.0
57.2
59
56
Z3229
NOMESCO Finland
Other healthcare associate professional
10.9
47.3
62
82
H83.8
ICD-10 Finland
Other specified diseases of inner ear
484.9
40.8
39
*
DFF00
NOMESCO Finland
Pure tone audiometry
8.4
37.8
61
102
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
9.9
37.2
50
67
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
14.1
30.6
30
25
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.4
28.7
61
133
N07CA01
ATC
betahistine; oral
8.1
28.3
44
69
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.4
19.8
67
210
DFF15
NOMESCO Finland
Speech audiometry
6.7
17.8
31
54
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
5.5
15.7
34
73
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
7.1
15.0
24
38
RD211, ,
NOMESCO Finland
6.7
14.2
24
40
R1260
NOMESCO Finland
Evaluation of communicative skills
14.5
13.3
22
17
Z3231
NOMESCO Finland
Registered nurse
3.1
12.2
76
341
Z00.0
ICD-10 Finland
General medical examination
3.2
11.1
56
220
R5140
NOMESCO Finland
Monitoring the use of the aid
3.9
11.1
37
111
R42
ICD-10 Finland
Dizziness and giddiness
3.1
10.7
57
231
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.5
10.5
28
71
UDC00
NOMESCO Finland
Ear microscopy
4.5
10.5
28
71
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
5.5
10.3
21
42
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.5
10.2
27
68
H93.1
ICD-10 Finland
Tinnitus
5.0
9.6
22
49
TDA90
NOMESCO Finland
Removal wax from ear
13.3
9.6
16
13
Z71.8
ICD-10 Finland
Other specified counselling
2.6
8.7
70
348
H13
ICPC
Plugged feeling ear
2.9
8.6
49
204
H81.0
ICD-10 Finland
Ménière disease
35.0
8.2
10
*
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.8
8.0
50
218
DAX08
NOMESCO Finland
Fitting of hearing aid
3.8
7.7
25
73
H81.3
ICD-10 Finland
Other peripheral vertigo
26.3
7.7
10
*
R5120
NOMESCO Finland
Preparation of an aid
6.5
7.6
19
32
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
8.1
7.1
15
20
H91.9
ICD-10 Finland
Hearing loss, unspecified
4.0
7.0
21
58
HMAK, ,
NOMESCO Finland
3.3
6.8
27
90
WNF00
NOMESCO Finland
Infection source and contact determination
41.6
6.8
8
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.3
6.1
64
351

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
95
589
2.26
6.88
9.3
9.0
0.00
0.00
e9/l
0.53
77
485
145
1140
2.26
5.02
19.9
17.8
14.60
15.04
%
0.44
140
1120
47
263
2.06
4.07
3.9
2.8
0.85
0.71
ug/l
0.51
25
172
89
645
1.73
3.33
4.8
5.6
55.90
58.37
%
0.94
82
604
87
628
1.73
3.29
4.4
5.5
0.75
0.64
%
0.99
79
580
88
639
1.72
3.24
4.7
5.6
3.06
2.80
%
0.34
81
593
88
644
1.70
3.12
5.0
5.9
8.68
8.70
%
0.02
81
603
89
655
1.69
3.08
4.8
5.8
29.25
26.68
%
1.02
82
612
23
108
2.29
3.06
2.9
4.6
—
0.09
—
0
35
5
6
8.52
2.76
1.8
1.2
—
—
—
0
0
89
678
1.60
2.55
4.4
5.4
0.56
0.59
e9/l
0.55
73
599
90
688
1.60
2.54
4.4
5.5
2.05
1.84
e9/l
0.40
83
623
89
679
1.60
2.53
4.4
5.4
0.04
0.04
e9/l
0.76
73
600
0
63
0.00
2.48
0.0
1.7
—
—
—
0
0
56
385
1.65
2.41
4.4
3.1
0.61
0.42
e6/l
0.25
37
289
55
379
1.64
2.34
4.4
3.0
—
—
—
0
0
90
699
1.56
2.31
4.8
5.6
0.22
0.19
e9/l
0.68
83
622
45
295
1.69
2.30
2.8
2.7
3.41
4.45
e6/l
0.56
35
268
164
1481
1.95
2.20
23.4
21.8
245.97
244.98
e9/l
0.07
159
1439
164
1482
1.94
2.18
23.3
21.7
4.41
4.45
e12/l
0.34
153
1434
164
1482
1.94
2.18
23.3
21.7
6.80
6.80
e9/l
0.01
153
1433
164
1482
1.94
2.18
23.3
21.8
40.20
39.65
%
0.63
157
1391
61
439
1.58
2.15
4.2
3.2
59.03
175.18
e6/l
0.36
40
343
44
292
1.67
2.15
2.6
3.1
544.89
556.79
mosm/kgh2o
0.13
37
252
30
179
1.81
2.12
1.4
1.3
—
—
—
0
0
99
798
1.52
2.07
9.2
8.6
4.00
4.16
e9/l
0.31
82
699
5
11
4.64
1.95
1.4
1.6
7.34
9.00
mmol/l
—
5
11
73
560
1.50
1.89
2.5
2.1
—
—
—
0
0
151
1349
1.65
1.88
16.5
15.0
25.69
25.23
mg/l
0.05
135
1093
81
646
1.45
1.69
5.0
6.0
—
—
—
0
0
144
1285
1.54
1.66
4.6
4.7
6.01
6.02
mmol/l
0.02
123
1156
110
932
1.44
1.64
4.2
4.0
—
—
—
0
0
5
14
3.64
1.62
1.2
1.6
—
—
—
0
0
153
1387
1.60
1.61
18.4
17.6
3.96
3.99
mmol/l
0.57
147
1346
148
1335
1.54
1.56
4.9
5.0
2.75
2.67
mmol/l
0.40
127
1210
84
683
1.42
1.55
5.6
6.7
1.22
1.21
mmol/l
0.31
76
579
24
148
1.71
1.53
2.4
2.4
71.99
147.95
ug/g
1.02
18
119
5
15
3.39
1.53
2.0
1.5
—
—
—
0
0
141
1261
1.50
1.53
3.9
4.0
1.40
1.26
mmol/l
1.41
122
1132
154
1405
1.57
1.49
13.7
13.8
—
—
—
0
0
113
974
1.41
1.46
4.3
3.8
14.42
14.80
pmol/l
0.96
107
878
118
1025
1.42
1.46
3.7
4.0
12.20
12.62
mm/h
0.13
112
936
65
509
1.43
1.46
4.5
3.7
297.35
97.08
e6/l
0.40
42
368
144
1300
1.49
1.42
4.4
4.5
1.39
1.45
mmol/l
0.82
125
1177
27
177
1.62
1.39
1.2
1.3
—
—
—
0
0
73
589
1.40
1.37
2.8
2.7
170.64
113.28
ug/l
0.40
63
538
5
17
2.99
1.36
1.6
1.6
57.38
57.22
%
—
5
17
6
24
2.55
1.31
2.3
2.9
32.17
18.58
u/ml
—
6
24
5
18
2.82
1.29
1.6
1.2
—
—
—
0
0
9
44
2.10
1.29
2.0
3.2
—
—
—
0
0
5
19
2.67
1.22
2.4
1.5
35.60
32.63
pg
—
5
19
5
19
2.67
1.22
1.4
1.7
—
—
—
0
0
0
34
0.00
1.17
0.0
1.6
—
5.30
—
0
13
36
263
1.46
1.15
2.4
2.6
2.42
2.45
mmol/l
0.70
24
233
26
179
1.53
1.10
4.4
5.4
104.92
104.39
mmol/l
0.19
26
179
18
113
1.66
1.10
3.3
3.8
1.23
1.22
mmol/l
0.48
18
103
25
172
1.52
1.07
1.6
1.5
—
—
—
0
0
59
477
1.35
1.06
4.2
2.9
2.37
2.35
mmol/l
0.44
48
412
9
47
1.96
1.04
2.8
1.5
—
—
—
0
0
7
131
0.52
1.03
6.9
4.5
—
—
—
0
0
47
368
1.37
1.03
1.8
1.5
20.09
20.89
nmol/l
0.12
37
304
35
261
1.42
1.01
5.3
3.4
220.07
357.53
ng/l
0.30
29
221
16
100
1.66
1.00
1.5
1.5
—
—
—
0
0
44
344
1.37
0.97
4.2
3.8
86.32
87.37
%
0.09
44
333
51
411
1.33
0.93
4.0
4.0
7.38
7.40
ph
0.76
11
79
68
571
1.30
0.93
2.1
2.0
92.84
94.61
pmol/l
0.12
30
284
133
1223
1.31
0.88
5.5
4.6
2.14
1.89
mu/l
0.77
117
1088
6
30
2.03
0.87
2.5
3.4
—
—
—
0
0
30
224
1.40
0.87
4.4
2.9
2.11
1.79
e6/l
—
9
126
11
175
0.61
0.83
1.4
1.5
—
—
—
0
0
0
26
0.00
0.79
0.0
1.7
—
19371.16
—
0
19
133
1232
1.28
0.78
6.0
6.3
41.22
40.77
mmol/mol
0.20
123
1135
19
133
1.48
0.77
1.5
3.9
2.25
1.65
mmol/l
0.17
13
107
70
603
1.26
0.76
3.7
4.3
34.69
35.36
g/l
0.50
65
566
19
134
1.47
0.75
1.5
3.9
5.77
5.74
kpa
0.05
19
126
9
144
0.61
0.73
1.1
1.4
—
—
—
0
0
9
57
1.61
0.72
3.3
2.9
—
—
—
0
0
43
353
1.28
0.69
8.9
6.2
—
—
—
0
0
5
27
1.87
0.69
1.6
2.8
—
—
—
0
0
11
70
1.61
0.67
4.5
15.4
—
—
—
0
0
5
28
1.81
0.66
1.0
1.3
—
—
—
0
0
22
165
1.38
0.64
2.9
4.1
2.17
49.69
ug/l
0.61
15
137
51
433
1.25
0.62
2.4
3.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.7
—
—
—
0
0
12
81
1.51
0.58
1.2
1.4
—
28.80
—
0
6
16
116
1.42
0.56
1.4
3.0
4.01
4.43
kpa
0.38
16
108
116
1079
1.20
0.55
8.1
7.2
74.12
78.03
u/l
0.46
108
997
6
97
0.61
0.53
3.5
3.2
4.83
5.08
kpa
—
6
92
6
100
0.59
0.53
1.2
1.4
—
—
—
0
0
34
281
1.26
0.52
1.2
1.2
0.65
2.12
u/ml
1.25
13
75
35
416
0.80
0.51
4.4
4.2
—
—
—
0
0
7
47
1.51
0.48
1.3
2.1
22.29
21.29
s
—
7
42
32
266
1.25
0.47
1.2
1.4
2.94
2.53
g/l
0.54
15
166
26
212
1.26
0.45
2.1
2.2
—
—
—
0
0
54
477
1.19
0.45
7.3
5.1
29.25
2.14
ug/l
0.67
43
417
39
334
1.21
0.44
3.0
3.0
8415.44
7077.50
umol/l
0.06
32
284
36
306
1.22
0.44
1.8
1.7
0.91
1.18
mg/l
0.65
23
229
6
95
0.62
0.43
3.3
3.3
—
7.42
—
0
8
11
79
1.42
0.41
1.4
1.2
—
—
—
0
0
64
577
1.17
0.41
4.1
3.9
25.33
47.88
ng/l
1.41
50
411
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
3.3
—
—
—
0
0
5
34
1.48
0.40
2.0
2.6
1.44
1.80
mg/l
—
5
29
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
8
112
0.70
0.38
4.3
3.0
—
—
—
0
0
33
381
0.84
0.37
4.6
3.8
0.00
0.01
estimate
0.50
19
128
10
134
0.73
0.36
4.1
2.1
3.48
5.37
ug/l
—
10
118
45
399
1.17
0.36
3.4
3.4
—
—
—
0
0
47
419
1.16
0.35
5.4
4.2
—
—
—
0
0
42
372
1.17
0.34
2.0
2.0
2.72
3.03
mg/l
0.43
33
323
15
119
1.28
0.33
2.3
2.5
65.68
69.49
e9/l
—
10
92
90
956
0.89
0.32
4.6
4.0
—
—
—
0
0
27
237
1.16
0.25
1.8
2.3
13.14
13.34
umol/l
0.05
27
213
10
78
1.30
0.24
1.0
1.2
—
—
—
0
0
14
115
1.24
0.24
2.7
2.0
66.12
65.55
g/l
0.14
14
100
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
1.77
—
0
11
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
12
100
1.21
0.18
1.7
2.0
—
—
—
0
0
7
58
1.21
0.18
1.9
2.0
42.03
36.93
g/l
—
7
50
8
69
1.17
0.16
1.6
2.8
0.61
0.66
%
—
8
69
13
111
1.18
0.16
4.6
7.6
—
—
—
0
0
8
72
1.12
0.16
1.6
2.8
0.69
1.22
%
—
8
72
9
81
1.12
0.15
1.6
2.4
—
—
—
0
0
11
129
0.84
0.15
1.5
2.2
0.21
0.21
g/l
0.09
11
116
7
89
0.78
0.15
1.1
1.4
—
—
—
0
0
12
103
1.18
0.14
1.8
1.7
—
—
—
0
0
9
105
0.85
0.13
2.8
2.6
—
—
—
0
0
9
109
0.82
0.13
1.2
1.4
—
—
—
0
0
19
171
1.12
0.13
4.8
8.6
5.27
5.06
kpa
0.61
19
164
19
171
1.12
0.13
4.8
8.6
10.97
11.46
kpa
0.20
19
165
71
684
1.06
0.12
16.2
15.9
1.30
1.29
inr
0.01
31
198
5
61
0.81
0.08
3.4
1.7
2.92
5.44
ug/l
—
5
52
6
70
0.85
0.08
1.2
1.2
—
—
—
0
0
7
80
0.87
0.07
3.0
3.8
—
—
—
0
0
70
682
1.04
0.07
5.5
5.1
0.00
0.01
estimate
0.50
19
134
10
89
1.13
0.07
1.4
1.5
—
—
—
0
0
9
102
0.88
0.06
3.4
8.5
—
—
—
0
0
22
230
0.95
0.03
1.2
1.2
14.29
40.01
iu/ml
—
8
70
41
421
0.97
0.03
4.0
3.8
8.87
8.95
mg/mmol
0.01
24
272
11
102
1.08
0.03
1.1
1.1
—
—
—
0
0
31
301
1.04
0.02
3.6
3.6
—
—
—
0
0
30
308
0.97
0.02
4.0
3.9
1.02
1.02
kg/l
—
5
53
45
442
1.02
0.01
2.4
2.3
—
—
—
0
0
23
223
1.04
0.01
1.3
1.2
0.65
14.37
u/ml
—
8
88
40
407
0.98
0.01
3.2
3.0
7.54
7.75
mmol/l
0.14
28
339
45
443
1.02
0.01
2.4
3.1
—
—
—
0
0
11
116
0.95
0.01
4.3
3.5
—
—
—
0
0
18
174
1.04
0.00
1.7
1.5
—
—
—
0
0
22
214
1.03
0.00
1.7
1.7
—
—
—
0
0
12
124
0.97
0.00
1.1
1.4
—
—
—
0
0
12
121
0.99
0.00
1.4
1.4
—
—
—
0
0
35
346
1.01
0.00
1.9
1.7
1.26
1.30
mmol/l
0.16
26
291
39
394
0.99
0.00
3.3
3.1
56.86
212.83
mg/l
0.50
31
266
70
696
1.01
0.00
4.0
3.7
0.00
0.00
estimate
-0.00
19
130
69
688
1.00
0.00
4.0
3.7
0.00
0.00
estimate
-0.00
20
146
34
335
1.02
0.00
1.3
1.4
—
—
—
0
0
15
152
0.99
0.00
1.5
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
72.78
—
0
9
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
34.60
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
21.18
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
174.08
—
0
8
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
10.5
—
0.64
—
0
6
0
7
0.00
-0.00
0.0
16.1
—
630.00
—
0
7
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
16.10
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
118.50
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
16.6
—
1205.57
—
0
7
5
55
0.91
-0.00
4.6
4.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
125.36
—
0
7
0
7
0.00
-0.00
0.0
6.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
0.78
—
0
7
7
75
0.93
-0.00
6.4
5.0
24.70
24.58
mmol/l
—
7
75
0
6
0.00
-0.00
0.0
2.2
—
2107.50
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
1.16
—
0
6
0
6
0.00
-0.00
0.0
4.3
—
57.00
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint H8_INNERNAS and mortality.

Females

Parameter HR [95% CI] p-value
H8_INNERNAS 0.994 [0.83, 1.19] 0.949
Birth year 0.992 [0.98, 1.0] 0.078

During the follow-up period (1.1.1998 — 31.12.2019), 195 out of 647 females with H8_INNERNAS died.

Males

Parameter HR [95% CI] p-value
H8_INNERNAS 0.865 [0.72, 1.03] 0.111
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 621 males with H8_INNERNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_INNERNAS.

N-year risk Females Males
1 0.068% 0.162%
5 0.537% 0.875%
10 1.345% 2.277%
15 2.663% 4.493%
20 4.46% 7.531%

Relationships between endpoints

↥

Index endpoint: H8_INNERNAS – Other specified/unspecified diseases of inner ear

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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