Labyrinthine fistula

H8_LABYRFISTU

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H83.1 Cause of death: ICD-10 — H83.1 2 out of 7 registries used, show all original rules.	108
4. Check minimum number of events None	108
5. Include endpoints None	108
6. Filter based on genotype QC (FinnGen only)	104

Control definitions (FinnGen only)

Control exclude: H8_INNER

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H83
Name in latin: Fistula labyrinthi

NAME	H8_LABYRFISTU
CONTROL_EXCLUDE	H8_INNER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H831
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H831
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Labyrinthine fistula based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	700	312	387
Only index persons	674	299	375
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	52.09	53.73	50.77
Only index persons	51.93	53.52	50.66

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	104	45	59
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	52.72	48.46	55.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
108: Matched controls
1080

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H83.1

ICD-10 Finland

Labyrinthine fistula

+∞

155.8

108

N07CA01

ATC

betahistine; oral

12.4

27.0

R42

ICD-10 Finland

Dizziness and giddiness

7.6

24.8

126

DFD20

NOMESCO Finland

Closure of rupture of round window

+∞

23.8

H81.3

ICD-10 Finland

Other peripheral vertigo

60.9

21.2

DFF00

NOMESCO Finland

Pure tone audiometry

7.8

20.0

UDC00

NOMESCO Finland

Ear microscopy

7.7

17.6

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

5.8

17.5

118

H91.2

ICD-10 Finland

Sudden idiopathic hearing loss

34.6

15.9

H90.4

ICD-10 Finland

Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

14.0

15.6

H81.0

ICD-10 Finland

Ménière disease

172.4

14.9

Z01.1

ICD-10 Finland

Examination of ears and hearing

5.6

13.6

H71

ICD-10 Finland

Cholesteatoma of middle ear

37.1

13.0

DFD30

NOMESCO Finland

Closure of perilymphatic fistula

+∞

12.7

DC1AD

NOMESCO Finland

Temporalbone CT

53.1

12.2

DFF59

NOMESCO Finland

Other assessment of balance

73.1

11.9

H80.0

ICD-10 Finland

Otosclerosis involving oval window, nonobliterative

+∞

11.7

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

36.5

10.6

DDA00

NOMESCO Finland

Stapedotomy

+∞

10.6

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

60.6

9.8

H80.9

ICD-10 Finland

Otosclerosis, unspecified

+∞

9.5

AA1AD

NOMESCO Finland

CT of head and brain

3.5

8.9

197

ZXC10

NOMESCO Finland

Use of laser

14.4

8.7

H81.1

ICD-10 Finland

Benign paroxysmal vertigo

7.4

8.5

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

24.2

8.2

DCA30

NOMESCO Finland

Exploration of middle ear

48.6

7.8

DE2CG

NOMESCO Finland

Acoustic channel extensive MRI examination with high intensity magnet

21.8

7.3

DAX08

NOMESCO Finland

Fitting of hearing aid

4.7

7.1

H93.1

ICD-10 Finland

Tinnitus

5.7

6.2

H60.3

ICD-10 Finland

Other infective otitis externa

11.0

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3013512) EKG study

278

3.11

7.78

5.2

4.3

—

(3019225) pH of Specimen

3.81

7.30

3.7

4.6

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

109

3.43

6.92

4.6

4.7

31.47

32.75

0.23

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

371

1.98

3.04

4.2

4.0

35.91

34.85

ng/l

0.03

265

(3022217) INR in Platelet poor plasma by Coagulation assay

421

1.82

2.39

10.4

14.0

1.19

1.24

inr

0.14

123

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

387

1.79

2.29

3.8

6.0

1.22

1.21

mmol/l

0.05

348

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

4.08

2.29

1.6

1.5

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

429

1.76

2.18

4.9

6.9

1.22

mmol/l

0.00

366

(4034850) Laboratory test

2.97

2.05

2.9

14.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

193

1.85

2.05

2.1

2.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

536

1.73

1.96

3.4

4.4

6.53

6.79

mmol/l

0.56

497

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.71

1.85

1.3

2.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

4.31

1.84

1.6

1.1

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

287

1.69

1.80

3.1

3.6

2335.63

1216.02

ng/l

0.55

250

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

107

1.94

1.68

4.4

9.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

623

1.67

1.63

2.8

3.1

40.62

49.92

u/l

0.83

589

(3004616) Nuclear Ab [Presence] in Serum

3.44

1.54

1.2

1.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.49

1.50

1.4

2.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

412

1.56

1.46

2.2

2.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.29

1.45

1.3

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

2.59

1.32

1.3

1.5

—

(3049717) Cytology report of Urine Cyto stain

2.19

1.21

2.4

2.9

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.57

1.16

1.2

1.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

105

1.73

1.14

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

847

1.71

1.10

5.4

5.8

38.69

39.98

mmol/mol

0.65

796

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

250

0.62

0.99

3.4

3.0

0.71

0.74

ug/l

0.10

169

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

2.01

0.99

3.6

5.0

25.13

25.02

mmol/l

—

(3031040) Bacteria [#/volume] in Urine by Automated count

576

1.43

0.99

4.6

4.3

—

4274.92

—

(1761868) Lipid panel - Serum or Plasma

355

0.68

0.93

2.6

2.9

—

(3044889) 12 lead EKG panel

635

0.73

0.86

4.8

4.2

—

(3045414) Leukocytes [Presence] in Urine

1.93

0.83

4.3

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.64

0.83

1.9

1.5

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.50

0.83

1.8

1.7

480.40

340.95

nmol/l

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.78

0.0

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

431

1.35

0.77

4.2

6.7

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.90

0.75

1.3

1.2

—

(3022313) Gas panel - Capillary blood

1.76

0.71

3.6

4.4

—

(3020891) Body temperature

1.76

0.71

2.0

4.9

—

(3013707) Erythrocyte sedimentation rate by Westergren method

666

1.35

0.71

4.5

4.1

9.97

11.23

mm/h

0.32

615

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.50

0.70

2.0

1.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

147

1.44

0.68

1.4

1.2

3.65

5.12

u/ml

—

(3052851) Hemolysis interference index of Serum or Plasma

1.76

0.64

2.4

2.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

111

0.61

0.62

1.7

1.5

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

101

969

1.65

0.62

10.3

10.5

23.66

26.38

u/l

1.61

940

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

0.61

0.0

2.2

—

25.54

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

562

1.29

0.60

2.8

3.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.60

0.0

1.2

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.60

0.0

1.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.55

0.60

1.4

1.6

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

142

1.41

0.59

1.7

2.1

28.07

29.38

0.67

135

(3019309) Folate [Moles/volume] in Red Blood Cells

179

1.36

0.57

2.0

1.7

1230.13

1290.44

nmol/l

0.12

137

(3023520) Reticulocytes [#/volume] in Blood

1.52

0.57

2.5

2.7

73.81

69.43

e9/l

0.15

(3019060) Gas panel - Arterial blood

1.57

0.56

2.0

4.5

—

(3026008) Bacteria identified in Urine by Culture

245

1.31

0.55

3.6

3.0

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.59

0.55

1.0

2.7

3.50

9.03

umol/l

—

(3013115) Eosinophils [#/volume] in Blood

477

1.26

0.54

3.8

6.3

0.18

e9/l

0.16

425

(3006504) Eosinophils/100 leukocytes in Blood

428

1.27

0.54

4.0

6.1

2.57

2.84

0.45

402

(3044640) Blood type and Crossmatch panel - Blood

265

1.29

0.53

1.8

2.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

620

1.26

0.51

5.5

4.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

192

1.32

0.51

1.6

1.8

423.89

466.53

pmol/l

0.37

161

(3019069) Monocytes/100 leukocytes in Blood

432

1.25

0.49

4.6

6.3

8.02

8.50

0.47

407

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

895

1.39

0.48

5.3

4.5

1.43

1.44

mmol/l

0.04

831

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

139

1.35

0.47

1.4

1.9

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

205

1.29

0.44

1.5

1.7

0.60

1.28

mg/l

1.65

160

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

300

0.78

0.44

1.8

2.9

24.88

31.11

u/l

1.67

283

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

877

1.33

0.43

4.7

4.0

1.24

1.29

mmol/l

0.28

812

(3018010) Neutrophils/100 leukocytes in Blood

437

1.22

0.43

4.0

5.9

58.13

57.29

0.20

413

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3024928) Oxygen saturation in Venous blood

0.00

0.41

0.0

3.1

—

(3028626) Oxygen [Partial pressure] in Capillary blood

0.00

0.41

0.0

2.3

—

7.94

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.41

0.0

2.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.41

0.0

1.8

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

900

1.34

0.41

5.2

4.6

4.60

4.59

mmol/l

0.04

840

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

900

1.34

0.41

15.6

14.4

22.33

21.87

mg/l

0.05

720

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.3

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.39

0.0

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.39

0.0

1.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.39

0.0

1.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

440

1.21

0.39

4.3

6.2

27.70

27.89

0.05

415

(3021601) Nitrite [Presence] in Urine by Test strip

450

0.82

0.39

6.4

5.2

0.00

estimate

—

100

(3015377) Calcium [Moles/volume] in Serum or Plasma

285

1.23

0.38

4.7

3.4

2.37

2.35

mmol/l

0.49

245

(40758558) Short blood count panel - Blood

242

0.79

0.38

6.4

6.6

—

(36660697) Celiac disease serology panel - Serum

1.31

0.38

1.3

1.1

—

(3022096) Basophils/100 leukocytes in Blood

412

1.20

0.37

4.2

6.1

0.82

0.66

1.12

385

(3041096) Erythrocytes [Presence] in Urine by Automated

252

0.79

0.37

4.3

3.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

198

0.77

0.36

4.1

3.9

—

(40761535) Cells panel - Urine sediment

1.41

0.36

2.4

3.6

—

(3009261) Glucose [Presence] in Urine by Test strip

457

0.83

0.36

4.4

3.9

0.00

estimate

—

(3020682) Albumin/Creatinine [Ratio] in Urine

270

1.21

0.33

3.0

4.0

1.86

11.51

mg/mmol

3.41

181

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

821

1.23

0.33

5.1

4.3

1.65

1.95

mu/l

2.50

747

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.37

0.32

2.9

2.7

3.64

4.42

pmol/l

—

(3042936) Bacteria identified in Isolate by Culture

141

0.76

0.32

1.5

1.7

—

(36304419) Bacteria [Presence] in Urine

257

0.82

0.31

2.5

2.7

—

(3009343) pH of Capillary blood

1.29

0.30

3.6

4.1

—

7.41

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

866

1.24

0.29

13.0

13.8

78.57

80.98

ml/min/173m2

0.54

704

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

327

0.85

0.28

4.8

4.7

18.28

21.31

0.76

156

(3001122) Ferritin [Mass/volume] in Serum or Plasma

372

1.16

0.27

3.1

2.7

218.01

133.23

ug/l

0.42

342

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

347

0.85

0.27

4.5

4.0

—

(21494755) Public health laboratory ask at order entry panel

1.33

0.27

1.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

412

1.16

0.27

5.2

5.1

2.15

2.86

ug/l

0.39

367

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

921

1.26

0.27

5.5

5.0

2.70

2.73

mmol/l

0.11

858

(40761536) Microorganisms panel - Urine sediment

0.72

0.25

3.3

3.4

—

(3012516) Albumin [Mass/volume] in Urine

258

1.17

0.24

2.6

3.2

16.91

81.96

mg/l

2.55

172

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

153

1.21

0.24

1.4

1.6

—

(40768443) Skin Pathology biopsy report

1.37

0.24

1.8

1.3

—

(3000330) Specific gravity of Urine by Test strip

1.26

0.23

11.0

4.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.23

0.22

1.0

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

443

0.88

0.22

4.3

3.9

0.00

estimate

—

108

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.4

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.3

—

1.20

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

2.8

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.2

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.21

0.0

1.5

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

195.48

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

3.46

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

1.02

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.21

0.0

1.5

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

4.4

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

5.83

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

2.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

1.8

—

64.55

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.21

0.0

3.0

—

7.89

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

270.83

—

(3022145) Colonoscopy Study observation

110

0.80

0.21

1.1

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

18.09

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

2.8

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.2

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.24

0.20

6.0

3.4

48.83

51.79

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

2.4

—

3.43

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.20

0.0

2.2

—

4.65

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.20

0.0

3.3

—

59.57

—

(3026493) Urate [Moles/volume] in Serum or Plasma

253

1.14

0.19

2.2

2.9

324.32

8368.61

umol/l

1.53

218

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

670

1.13

0.19

4.0

3.6

14.49

14.85

pmol/l

0.51

602

(3024561) Albumin [Mass/volume] in Serum or Plasma

381

1.12

0.19

3.7

4.7

37.03

35.54

g/l

1.37

364

(3021960) Folate [Moles/volume] in Serum or Plasma

215

1.15

0.18

1.4

1.6

13.74

21.54

nmol/l

2.44

179

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

366

0.90

0.16

2.3

2.4

78.68

77.06

nmol/l

0.15

321

(3007461) Platelets [#/volume] in Blood

102

1004

1.29

0.16

21.9

21.3

235.00

243.13

e9/l

0.91

975

(3009542) Hematocrit [Volume Fraction] of Blood

102

1004

1.29

0.16

21.7

21.2

41.07

40.57

0.54

949

(3000492) Spirometry study

1.23

0.16

1.6

1.4

—

(3009508) Creatinine [Moles/volume] in Urine

276

1.12

0.16

2.5

3.1

8.23

7.90

mmol/l

0.16

240

(40768804) Tissue Pathology biopsy report

356

1.10

0.14

2.6

2.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.21

0.14

1.6

1.8

—

(3002256) Pathology report gross observation

106

0.84

0.13

1.7

1.2

—

(3000494) Fungus identified in Specimen by Culture

107

0.83

0.13

1.3

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

127

0.85

0.13

1.6

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

157

0.88

0.12

1.6

1.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

361

1.08

0.10

1.8

1.9

93.70

94.99

pmol/l

0.06

191

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.09

0.10

4.4

3.3

24.68

24.18

mmol/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

732

1.08

0.09

6.3

7.6

73.55

77.15

u/l

0.69

687

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.07

0.09

1.0

2.5

0.80

0.69

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.81

0.08

1.8

1.5

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

215

1.09

0.08

1.8

1.9

2.55

2.95

mg/l

0.64

185

(3004588) Protein electrophoresis panel - Serum or Plasma

1.10

0.08

1.3

2.7

—

(3003694) ABO and Rh group [Type] in Blood

234

0.92

0.07

1.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.09

0.07

1.0

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

100

0.89

0.06

1.1

1.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

104

0.85

0.06

1.6

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

334

0.94

0.06

3.5

3.1

—

(40768797) Stomach Pathology biopsy report

111

0.89

0.06

1.1

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

892

1.05

0.02

5.0

4.5

5.91

5.98

mmol/l

0.32

826

(3020564) Creatinine [Moles/volume] in Serum or Plasma

963

1.07

0.02

17.4

17.1

82.35

80.05

umol/l

0.44

963

(3014576) Chloride [Moles/volume] in Serum or Plasma

104

1.06

0.01

3.0

6.6

105.00

103.65

mmol/l

0.57

104

(40761511) CBC panel - Blood by Automated count

947

1.03

0.00

15.9

13.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

183

0.98

0.00

1.3

1.5

2.29

2.45

g/l

—

111

(3023368) Bacteria identified in Blood by Culture

243

0.98

0.00

2.8

4.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

545

0.98

0.00

7.4

10.3

3.97

4.11

e9/l

0.16

483

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.06

0.00

1.6

2.0

—

(3027801) Oxygen [Partial pressure] in Arterial blood

1.01

0.00

2.0

7.0

10.51

11.02

kpa

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

2.6

—

(3004451) EKG impression Narrative

0.00

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

11.0

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.0

—

10.94

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.1

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.0

—

145.96

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.00

-0.00

1.1

2.4

0.28

0.22

g/l

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.1

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

4.8

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

12.35

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.00

-0.00

1.5

1.6

—

(3025577) Chromium [Mass/volume] in Blood

0.00

-0.00

0.0

2.5

—

2.47

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

3.6

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.02

-0.00

1.0

2.4

1.56

1.39

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.4

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

1.6

—

16.76

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

2.0

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

12.7

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.6

—

13.20

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

3.0

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.5

—

4.65

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

1.8

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.2

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.2

—

158.11

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

63.83

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.4

—

11.12

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.6

—

(4035726) Immunohistochemistry procedure

0.97

-0.00

1.8

1.3

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

19.9

—

1684.63

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

-0.00

0.0

1.2

—

8.08

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3022621) pH of Urine by Test strip

1.00

-0.00

3.7

2.7

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.1

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

2.0

—

7.60

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

3.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.6

—

(3047189) Immunofixation for 24 hour Urine

0.00

-0.00

0.0

2.2

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.1

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

4.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

1.50

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.6

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

11.15

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.93

-0.00

1.1

1.7

—

(3016502) Oxygen saturation in Arterial blood

1.00

-0.00

2.0

7.5

96.70

95.28

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.91

-0.00

3.2

4.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_LABYRFISTU and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_LABYRFISTU.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_LABYRFISTU – Labyrinthine fistula

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Labyrinthine fistula

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints