labyrinthitis: Inflammation of the inner ear. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication. [ https://en.wikipedia.org/wiki/Labyrinthitis NCIT:C128369 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
107 |
4. Check minimum number of eventsNone |
107 |
5. Include endpointsNone |
107 |
6. Filter based on genotype QC (FinnGen only) |
107 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H83
- Name in latin
- Fistula labyrinthi
Similar endpoints
↥List of similar endpoints to
Labyrinthine fistula
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 700 | 312 | 387 |
| Only index persons | 674 | 299 | 375 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 52.09 | 53.73 | 50.77 |
| Only index persons | 51.93 | 53.52 | 50.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 107 | 46 | 61 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 52.32 | 47.49 | 55.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 101
- Matched controls
- 1008
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.1
ICD-10 Finland
Labyrinthine fistula
+∞
145.6
101
*
DFD20
NOMESCO Finland
Closure of rupture of round window
+∞
21.6
20
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
27.1
18.4
25
12
H81.3
ICD-10 Finland
Other peripheral vertigo
77.0
17.4
19
*
N07CA01
ATC
betahistine; oral
15.5
15.7
26
22
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
50.5
14.6
17
*
DC1AD
NOMESCO Finland
Temporalbone CT
160.7
13.8
14
*
UDC00
NOMESCO Finland
Ear microscopy
10.5
13.1
26
32
H71
ICD-10 Finland
Cholesteatoma of middle ear
37.5
13.0
16
5
DFF00
NOMESCO Finland
Pure tone audiometry
9.6
12.8
27
37
H81.0
ICD-10 Finland
Ménière disease
+∞
12.8
12
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
7.5
12.6
32
59
R42
ICD-10 Finland
Dizziness and giddiness
5.6
12.3
42
114
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
5.8
12.1
39
99
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
73.7
11.9
13
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
10.6
10
*
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
+∞
10.6
10
*
DFD30
NOMESCO Finland
Closure of perilymphatic fistula
+∞
10.6
10
*
DFF59
NOMESCO Finland
Other assessment of balance
61.0
9.9
11
*
ZXC10
NOMESCO Finland
Use of laser
24.5
9.6
13
6
DCA30
NOMESCO Finland
Exploration of middle ear
+∞
9.5
9
*
H80.9
ICD-10 Finland
Otosclerosis, unspecified
+∞
9.5
9
*
DDA00
NOMESCO Finland
Stapedotomy
+∞
9.5
9
*
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
9.1
9.2
19
25
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
24.4
8.2
11
5
DCD00
NOMESCO Finland
Myringoplasty
+∞
7.4
7
*
H93.1
ICD-10 Finland
Tinnitus
6.6
6.8
17
30
H66.9
ICD-10 Finland
Otitis media, unspecified
12.2
6.5
11
10
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
+∞
6.3
6
*
DEB30
NOMESCO Finland
Radical mastoidectomy
+∞
6.3
6
*
H60.3
ICD-10 Finland
Other infective otitis externa
11.0
6.2
11
11
AA1AD
NOMESCO Finland
CT of head and brain
3.3
6.2
36
146
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
108
3.47
7.04
4.7
4.7
31.5
32.6
%
0.20
19
72
55
367
2.03
3.19
4.2
4.0
36.7
35.1
ng/l
0.04
39
262
54
386
1.81
2.33
3.8
5.9
1.2
1.2
mmol/l
0.02
42
347
31
190
1.89
2.16
2.1
2.4
—
—
—
0
0
68
528
1.79
2.16
3.4
4.4
6.5
6.8
mmol/l
0.63
63
488
5
10
5.18
2.09
1.6
1.1
—
—
—
0
0
57
426
1.72
2.02
4.8
6.9
1.2
1.2
mmol/l
0.02
42
361
9
35
2.71
1.85
1.3
2.0
—
—
—
0
0
19
107
1.94
1.68
4.4
9.2
—
—
—
0
0
74
615
1.66
1.60
2.7
3.1
41.0
50.2
u/l
0.79
65
582
40
286
1.64
1.59
3.1
3.6
2403.0
1218.1
ng/l
0.57
34
250
9
38
2.49
1.50
1.4
2.3
—
—
—
0
0
10
46
2.29
1.45
1.3
1.2
—
—
—
0
0
52
407
1.54
1.37
3.5
4.3
—
—
—
0
0
6
26
2.38
1.20
1.3
1.4
—
—
—
0
0
5
21
2.45
1.10
1.2
1.5
—
—
—
0
0
92
838
1.70
1.08
5.4
5.9
38.5
40.0
mmol/mol
0.84
79
788
7
36
2.01
0.99
3.6
5.0
25.1
25.0
mmol/l
—
7
36
17
243
0.64
0.87
3.4
3.0
0.7
0.7
ug/l
0.12
11
163
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
5
91
0.53
0.71
2.0
1.8
—
—
—
0
0
5
95
0.50
0.70
1.8
1.8
480.4
351.0
nmol/l
—
5
82
73
660
1.33
0.66
4.5
4.2
10.0
11.4
mm/h
0.34
67
610
20
148
1.43
0.66
1.4
1.2
3.7
5.1
u/ml
—
10
60
19
140
1.43
0.64
1.7
2.1
28.1
29.4
s
0.68
19
133
100
959
1.65
0.62
10.3
10.5
23.4
26.3
u/l
1.87
91
931
8
54
1.52
0.59
1.4
1.6
—
—
—
0
0
23
179
1.36
0.58
2.0
1.7
1230.1
1297.8
nmol/l
0.13
16
138
62
555
1.28
0.57
2.8
3.0
—
—
—
0
0
6
98
0.59
0.55
1.0
2.7
3.5
9.0
umol/l
—
6
86
24
296
0.76
0.53
1.7
2.9
24.7
31.2
u/l
1.73
24
279
39
449
0.79
0.50
6.4
5.2
0.0
0.0
estimate
—
5
99
40
456
0.80
0.46
4.4
3.9
0.0
0.0
estimate
—
5
93
93
887
1.37
0.45
5.3
4.5
1.4
1.4
mmol/l
0.00
80
822
90
855
1.33
0.44
12.6
13.7
78.6
80.7
ml/min/173m2
0.46
76
693
91
867
1.33
0.43
4.7
4.0
1.2
1.3
mmol/l
0.24
77
803
33
283
1.24
0.41
4.7
3.4
2.4
2.3
mmol/l
0.52
23
241
93
891
1.33
0.39
15.5
14.3
22.4
21.9
mg/l
0.05
78
711
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
93
892
1.33
0.38
5.2
4.5
4.6
4.6
mmol/l
0.16
80
831
23
191
1.26
0.37
1.6
1.8
433.5
464.5
pmol/l
0.24
18
160
30
344
0.82
0.35
4.6
4.0
—
—
—
0
0
24
203
1.23
0.34
1.5
1.7
0.6
1.2
mg/l
1.26
17
157
40
441
0.85
0.30
4.4
3.8
0.0
0.0
estimate
—
5
101
85
814
1.22
0.29
5.1
4.3
1.6
2.0
mu/l
2.57
75
741
28
317
0.84
0.28
4.7
4.7
18.1
21.6
%
0.88
16
150
44
401
1.17
0.28
5.2
5.1
2.1
2.8
ug/l
0.38
38
356
17
141
1.24
0.28
1.4
1.9
—
—
—
0
0
94
912
1.25
0.25
5.5
5.0
2.7
2.7
mmol/l
0.03
80
848
18
153
1.21
0.24
1.4
1.6
—
—
—
0
0
5
40
1.26
0.23
1.0
1.3
—
—
—
0
0
8
102
0.77
0.22
1.1
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
1.2
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
5.8
—
0
6
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
4.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
18.8
—
0
12
33
361
0.88
0.21
2.2
2.4
79.0
77.3
nmol/l
0.15
28
317
6
49
1.24
0.20
6.0
3.4
48.8
51.8
%
—
6
49
40
371
1.12
0.19
3.1
2.7
221.7
132.5
ug/l
0.43
34
341
7
60
1.18
0.18
3.7
8.4
23.7
24.6
mmol/l
—
7
55
69
664
1.11
0.16
4.0
3.6
14.5
14.9
pmol/l
0.54
61
598
40
375
1.11
0.15
3.4
4.7
37.0
35.6
g/l
1.21
33
357
10
84
1.21
0.14
1.6
1.8
—
—
—
0
0
8
98
0.80
0.14
1.1
1.7
—
—
—
0
0
9
105
0.84
0.13
1.6
1.4
—
—
—
0
0
90
883
1.12
0.11
5.0
4.5
5.9
6.0
mmol/l
0.31
75
818
31
329
0.92
0.10
3.5
3.1
—
—
—
0
0
23
214
1.10
0.09
1.4
1.6
13.0
21.9
nmol/l
2.89
16
178
6
53
1.14
0.09
3.2
2.6
3.6
4.4
pmol/l
—
6
48
27
254
1.08
0.09
2.1
2.9
324.8
8405.8
umol/l
1.53
21
217
74
723
1.08
0.09
6.3
7.6
73.0
77.2
u/l
0.87
66
680
37
358
1.05
0.05
1.8
1.9
93.7
95.2
pmol/l
0.07
21
189
96
953
1.07
0.02
17.2
17.1
82.0
80.2
umol/l
0.32
96
953
10
94
1.07
0.01
1.6
2.0
—
—
—
0
0
22
214
1.04
0.00
1.8
2.0
2.6
3.0
mg/l
0.46
15
184
54
541
1.00
0.00
7.4
10.4
4.0
4.1
e9/l
0.14
49
479
0
9
0.00
0.00
0.0
3.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
5.0
—
—
—
0
0
5
49
1.02
0.00
1.0
2.4
1.6
1.4
%
—
5
49
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
5.0
—
146.0
—
0
7
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
16.8
—
0
5
0
6
0.00
0.00
0.0
1.8
—
63.8
—
0
6
0
5
0.00
0.00
0.0
1.6
—
13.2
—
0
5
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
9
99
0.90
0.00
3.2
3.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
11.1
—
0
5
0
7
0.00
0.00
0.0
1.6
—
10.4
—
0
7
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_LABYRFISTU and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H8_LABYRFISTU.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H8_LABYRFISTU – Labyrinthine fistula
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data