cholinergic urticaria: a type of physical urticarias (or hives) that appears when a person is sweating.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
187 |
4. Check minimum number of eventsNone |
187 |
5. Include endpointsNone |
187 |
6. Filter based on genotype QC (FinnGen only) |
180 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50
- Name in latin
- Urticaria cholinergica
Similar endpoints
↥List of similar endpoints to
Cholinergic urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1274 | 625 | 643 |
| Only index persons | 1222 | 606 | 616 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 28.90 | 35.86 | 22.06 |
| Only index persons | 28.80 | 35.69 | 22.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 180 | 109 | 71 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 37.29 | 43.73 | 27.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 187
- Matched controls
- 1870
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
225.5
168
*
XQ800
NOMESCO Finland
Prick test
10.9
42.9
54
67
L50.3
ICD-10 Finland
Dermatographic urticaria
268.8
42.8
42
*
R06AE09
ATC
levocetirizine; oral
7.9
41.3
77
152
C01CA24
ATC
epinephrine; parenteral
9.1
32.6
46
65
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
7.7
31.9
54
94
R03DC03
ATC
montelukast; oral
6.2
31.2
73
175
L50.9
ICD-10 Finland
Urticaria, unspecified
30.4
27.9
37
15
L50.0
ICD-10 Finland
Allergic urticaria
44.1
27.2
33
9
L50.8
ICD-10 Finland
Other urticaria
286.7
25.3
25
*
R06AE07
ATC
cetirizine; oral
5.3
25.3
135
616
R06AX27
ATC
desloratadine; oral
4.7
24.9
103
386
R06AX22
ATC
ebastine; oral
4.8
22.5
71
213
L50.2
ICD-10 Finland
Urticaria due to cold and heat
235.1
21.0
21
*
T78.4
ICD-10 Finland
Allergy, unspecified
8.7
19.2
26
34
L50.1
ICD-10 Finland
Idiopathic urticaria
74.1
18.1
20
*
7085A
ICD-9 Finland
Urticaria, Cholinergic urticaria
+∞
18.0
17
*
N05BB01
ATC
hydroxyzine; systemic
7.2
16.8
27
43
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.7
16.1
44
115
H02AB06
ATC
prednisolone; systemic
3.5
15.4
115
590
R06AX13
ATC
loratadine; oral
3.7
13.2
53
182
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.4
12.6
58
217
J45
ICD-10 Finland
Asthma
4.3
11.8
34
92
L20.0
ICD-10 Finland
Besnier prurigo
4.2
11.3
33
90
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.0
11.1
35
101
XQ810
NOMESCO Finland
Physical test for urticaria
+∞
10.5
10
*
D07AC13
ATC
mometasone; topical
2.8
9.9
68
316
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
9.7
74
362
A02BA02
ATC
ranitidine; systemic
3.2
9.3
44
165
D07AC01
ATC
betamethasone; topical
2.6
9.3
80
414
D07AB08
ATC
desonide; topical
3.5
9.2
36
120
R06AX26
ATC
fexofenadine; oral
4.1
9.1
27
74
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
25.5
9.0
12
5
E000001, ,
ATC
2.8
8.9
55
240
XQ802
NOMESCO Finland
Epicutan test
8.0
8.7
19
26
344
Kela drug reimbursment
Omalizumab
+∞
8.4
8
*
E0000UV, ,
ATC
2.5
8.4
94
545
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
8.1
83
460
R03AC02
ATC
salbutamol; inhalant
2.4
7.5
120
800
D02AE01
ATC
carbamide; topical
4.5
7.5
19
46
R03DX05
ATC
omalizumab; parenteral
+∞
7.3
7
*
L40.5
ICD-10 Finland
Arthropathic psoriasis
16.6
7.3
11
7
L50
ICD-10 Finland
Urticaria
9.9
6.9
13
14
H04.10
ICD-10 Finland
Dry eye syndrome
3.0
6.7
32
120
R96
ICPC
Asthma
3.4
6.6
25
81
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.8
6.5
21
61
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
6.5
81
479
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
6.3
47
221
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
18.8
6.3
9
5
N03AX16
ATC
[U] pregabalin
2.4
6.2
50
244
R20.2
ICD-10 Finland
Paraesthesia of skin
3.5
6.1
22
69
R01AD09
ATC
mometasone; nasal
2.1
6.0
99
647
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
88
562
2.07
5.56
4.2
6.1
1.23
1.22
mmol/l
0.66
81
522
144
1130
2.19
4.91
5.7
3.7
10.59
9.68
mm/h
0.26
136
1050
65
393
2.00
4.60
1.8
1.6
—
—
—
0
0
71
449
1.94
4.38
2.5
2.8
—
—
—
0
0
59
351
1.99
4.34
2.8
2.6
0.10
0.24
e6/l
1.28
47
255
37
185
2.25
4.26
2.2
3.8
0.82
0.83
mmol/l
0.33
31
175
76
501
1.87
4.08
2.0
1.8
94.60
96.80
pmol/l
0.18
35
261
24
102
2.55
3.93
1.2
1.2
95.33
144.42
iu/ml
—
6
45
89
623
1.82
3.90
4.9
6.8
1.22
1.22
mmol/l
0.27
77
534
11
26
4.43
3.57
1.9
4.5
50.91
57.96
%
0.70
11
26
34
181
2.07
3.33
2.0
2.5
2.81
3.25
e6/l
0.10
20
88
92
673
1.72
3.31
3.0
2.5
147.27
90.79
ug/l
0.50
86
634
141
1166
1.85
3.26
5.1
3.8
15.04
14.56
pmol/l
1.59
130
1071
36
201
1.98
3.10
1.9
2.4
0.27
0.88
e6/l
2.55
22
108
10
26
4.00
3.03
1.9
4.3
3.74
3.96
e9/l
—
10
26
112
887
1.65
2.82
9.1
9.5
3.61
3.95
e9/l
1.27
105
778
45
280
1.80
2.78
1.5
1.4
21.81
21.49
nmol/l
0.04
33
246
44
276
1.78
2.64
1.3
1.3
12.03
24.79
iu/ml
1.62
16
100
19
88
2.29
2.61
1.1
1.0
—
—
—
0
0
77
565
1.62
2.57
2.7
2.2
75.26
75.00
nmol/l
0.03
70
520
172
1559
2.29
2.52
13.7
11.5
13.11
20.71
mg/l
3.99
126
1191
32
185
1.88
2.48
1.7
2.1
2.27
2.47
g/l
1.07
26
171
159
1405
1.88
2.47
6.0
4.4
1.63
2.68
mu/l
0.66
152
1302
11
38
3.01
2.46
1.0
1.2
3.40
3.82
mmol/l
1.17
11
33
55
375
1.66
2.44
1.6
1.3
3.08
1.44
u/ml
—
9
110
9
27
3.45
2.42
1.1
1.1
—
—
—
0
0
48
316
1.70
2.42
1.8
1.6
0.77
1.05
mg/l
0.47
30
242
11
43
2.65
2.12
1.2
1.2
—
—
—
0
0
62
450
1.57
2.10
4.0
3.1
2.35
2.35
mmol/l
0.01
50
401
66
491
1.53
1.99
3.3
3.4
29.24
22.15
ng/l
0.24
38
289
52
371
1.56
1.88
1.7
1.7
1.22
1.44
mmol/l
1.20
40
322
40
268
1.63
1.87
1.4
1.2
1.19
10.09
u/ml
2.11
18
112
29
178
1.74
1.87
1.9
2.1
21.86
24.17
%
0.51
24
151
9
35
2.65
1.82
2.2
2.4
147.78
167.74
%
—
9
35
66
503
1.48
1.74
3.1
3.0
32.34
32.09
u/l
0.02
59
476
11
48
2.37
1.74
2.3
1.5
—
—
—
0
0
152
1366
1.60
1.73
17.4
13.7
13.63
14.42
%
1.89
152
1350
39
265
1.60
1.72
2.4
2.3
—
—
—
0
0
88
711
1.45
1.71
4.6
4.5
0.00
0.00
estimate
-0.00
23
139
88
713
1.44
1.68
3.3
3.2
0.00
0.00
estimate
-0.00
23
144
6
19
3.23
1.67
3.0
2.0
—
—
—
0
0
34
225
1.62
1.67
3.2
3.2
265.75
501.91
ng/l
0.26
24
149
10
42
2.46
1.64
1.2
1.2
—
—
—
0
0
135
1193
1.47
1.57
3.2
3.4
—
—
—
0
0
5
15
3.39
1.53
1.2
1.1
—
—
—
0
0
5
15
3.39
1.53
1.2
1.1
—
—
—
0
0
5
15
3.39
1.53
1.2
1.1
—
—
—
0
0
5
15
3.39
1.53
1.2
1.1
—
—
—
0
0
5
15
3.39
1.53
1.2
1.1
—
—
—
0
0
71
561
1.43
1.52
4.4
4.4
37.92
36.69
g/l
1.50
65
533
72
573
1.42
1.48
3.2
3.2
—
—
—
0
0
11
52
2.19
1.47
1.8
1.7
—
—
—
0
0
87
721
1.39
1.39
3.3
3.3
0.00
0.00
estimate
-0.00
21
134
5
17
2.99
1.36
1.4
1.4
—
—
—
0
0
0
37
0.00
1.36
0.0
1.6
—
—
—
0
0
0
37
0.00
1.36
0.0
1.6
—
—
—
0
0
9
43
2.15
1.32
4.2
2.9
—
—
—
0
0
8
34
2.41
1.31
1.4
1.2
—
—
—
0
0
5
19
2.67
1.22
1.0
1.1
—
—
—
0
0
174
1650
1.78
1.20
12.3
9.2
25.24
27.53
u/l
1.64
168
1603
5
20
2.54
1.16
1.0
1.1
—
—
—
0
0
69
565
1.35
1.15
11.4
10.2
1.18
1.15
inr
0.09
23
168
41
310
1.41
1.10
1.7
2.3
—
—
—
0
0
5
21
2.42
1.09
3.8
5.6
367.80
366.13
umol/l
—
5
16
5
21
2.42
1.09
1.0
1.1
—
—
—
0
0
125
1123
1.34
1.08
3.3
2.9
37.97
41.80
u/l
0.38
118
1073
38
285
1.42
1.06
2.3
1.9
2.49
3.14
mg/l
1.43
31
253
92
794
1.31
1.05
3.8
4.7
6.30
6.38
mmol/l
0.13
86
720
5
22
2.31
1.04
1.0
2.2
6.52
5.52
u/ml
—
5
22
49
387
1.36
1.02
3.3
3.3
0.00
0.00
estimate
-0.00
21
138
14
84
1.72
1.01
1.1
1.4
—
—
—
0
0
9
51
1.80
0.96
1.3
2.2
—
—
—
0
0
19
127
1.55
0.93
2.6
4.2
258.32
232.53
u/l
0.23
19
121
32
239
1.41
0.92
2.2
2.2
—
—
—
0
0
6
28
2.18
0.92
1.0
1.7
—
—
—
0
0
44
347
1.35
0.92
2.8
2.6
335.13
2237.57
umol/l
0.80
38
309
8
45
1.81
0.85
1.0
1.1
—
1.20
—
0
7
6
32
1.90
0.82
1.3
1.3
—
—
—
0
0
0
24
0.00
0.80
0.0
1.4
—
—
—
0
0
0
26
0.00
0.79
0.0
1.8
—
—
—
0
0
0
26
0.00
0.79
0.0
1.8
—
—
—
0
0
0
27
0.00
0.78
0.0
1.4
—
—
—
0
0
0
27
0.00
0.78
0.0
1.6
—
—
—
0
0
28
211
1.38
0.78
2.0
2.7
2.42
2.44
mmol/l
0.40
21
181
6
34
1.79
0.77
1.0
1.1
—
—
—
0
0
6
34
1.79
0.77
1.8
2.5
—
—
—
0
0
5
24
2.11
0.75
1.2
1.4
—
—
—
0
0
152
1434
1.32
0.74
14.7
10.1
90.41
88.60
ml/min/173m2
0.46
125
1150
14
204
0.66
0.73
1.5
1.8
—
—
—
0
0
5
28
1.81
0.66
2.2
1.6
—
—
—
0
0
39
318
1.29
0.66
2.5
3.0
743.36
881.23
ng/l
0.22
27
263
10
63
1.62
0.63
4.0
4.8
25.48
25.65
mmol/l
—
10
63
0
20
0.00
0.60
0.0
1.9
—
—
—
0
0
11
72
1.56
0.60
1.9
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
27
212
1.32
0.60
2.0
1.6
1120.50
1214.83
nmol/l
0.26
20
164
8
54
1.50
0.58
1.8
1.4
—
—
—
0
0
8
55
1.47
0.57
1.4
1.1
—
—
—
0
0
6
38
1.60
0.55
1.0
1.1
—
—
—
0
0
7
46
1.54
0.49
2.0
1.5
—
—
—
0
0
10
142
0.69
0.48
1.5
1.6
—
—
—
0
0
5
83
0.59
0.47
3.4
12.1
25.32
24.51
mmol/l
—
5
78
7
51
1.39
0.44
1.1
1.1
—
—
—
0
0
10
139
0.70
0.43
1.5
1.6
—
—
—
0
0
5
32
1.58
0.42
2.2
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
2.0
—
—
—
0
0
29
243
1.23
0.41
5.0
4.2
19.02
21.33
%
0.40
12
99
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
11
80
1.40
0.39
1.4
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
16
127
1.28
0.35
4.2
2.9
—
—
—
0
0
14
109
1.31
0.34
3.5
2.1
—
—
—
0
0
17
138
1.26
0.32
2.2
6.4
104.59
104.00
mmol/l
0.31
17
138
22
187
1.20
0.28
1.3
1.7
—
—
—
0
0
10
124
0.80
0.22
3.1
10.5
5.01
5.09
kpa
—
10
117
10
124
0.80
0.22
3.1
10.5
14.50
12.51
kpa
—
10
117
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
106.13
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
3.00
—
0
7
155
1517
1.13
0.21
4.3
3.9
1.44
1.48
mmol/l
0.65
147
1417
6
48
1.26
0.20
2.3
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
3.4
—
875.14
—
0
14
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
150
1469
1.11
0.18
3.7
3.5
1.29
1.27
mmol/l
0.12
141
1365
34
313
1.11
0.16
1.3
1.4
—
—
—
0
0
155
1524
1.10
0.15
4.3
3.9
4.76
4.76
mmol/l
0.02
148
1433
15
170
0.87
0.14
4.3
6.1
—
—
—
0
0
148
1454
1.09
0.14
4.7
3.9
5.66
5.76
mmol/l
0.40
136
1359
139
1364
1.07
0.13
5.3
4.9
38.31
38.68
mmol/mol
0.22
131
1294
157
1549
1.08
0.11
4.8
4.3
2.91
2.85
mmol/l
0.31
148
1448
69
669
1.05
0.09
2.2
2.5
—
—
—
0
0
7
65
1.08
0.08
1.6
1.7
—
—
—
0
0
6
71
0.84
0.08
2.0
1.3
—
—
—
0
0
14
152
0.91
0.06
3.4
4.2
33.13
30.67
%
—
8
104
14
132
1.07
0.02
3.4
1.8
370.07
385.81
nmol/l
0.17
14
119
38
373
1.02
0.01
3.6
3.9
8.94
8.39
mg/mmol
0.03
18
238
14
143
0.98
0.00
4.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
59
1.02
-0.00
1.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
9
90
1.00
-0.00
2.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
6
68
0.88
-0.00
1.7
1.4
—
—
—
0
0
5
58
0.86
-0.00
1.4
3.6
55.02
50.51
%
—
5
58
5
50
1.00
-0.00
1.2
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICA_CHOLINERG and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_URTICA_CHOLINERG.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_URTICA_CHOLINERG – Cholinergic urticaria
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data