Deformity of finger(s)

M13_FINGERDEFORM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

226

4. Check minimum number of events

None

226

5. Include endpoints

None

226

6. Filter based on genotype QC (FinnGen only)

226

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1492 854 627
Only index persons 1395 803 592
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 50.52 50.87 49.88
Only index persons 50.09 50.51 49.51

-FinnGen-

Key figures

All Female Male
Number of individuals 226 133 93
Unadjusted period prevalence (%) 0.04 0.05 0.04
Median age at first event (years) 52.14 50.39 54.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
207
Matched controls
2068
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M20.00
ICD-10 Finland
Buttonhole deformity of fingers
+∞
126.3
108
*
M20.01
ICD-10 Finland
Swan neck deformity of fingers
+∞
51.2
47
*
M20.08
ICD-10 Finland
Deformity of finger(s)
+∞
50.0
46
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
51.7
38.1
45
11
M19.0
ICD-10 Finland
Primary arthrosis of other joints
52.2
29.8
35
8
M17.1
ICD-10 Finland
Other primary gonarthrosis
21.1
23.1
34
19
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
40.1
22.7
28
8
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
22.3
21
*
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
21.2
20
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
64.2
20.3
23
*
A07EC01
ATC
sulfasalazine; oral, rectal
20.0
18.8
28
16
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
18.0
17
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
104.0
17.9
19
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
11.7
17.7
33
33
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
16.9
16
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
15.8
15
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
+∞
15.8
15
*
M25.5
ICD-10 Finland
Pain in joint
4.4
15.4
64
192
M20.2
ICD-10 Finland
Hallux rigidus
+∞
14.8
14
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
14.8
14
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
7.5
14.1
34
53
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
11.6
13.1
24
23
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
13.5
12.9
22
18
NDG76
NOMESCO Finland
Fusion of DIP joint
74.5
12.7
14
*
S66.3
ICD-10 Finland
Injury of extensor muscle and tendon of other finger at wrist and hand level
14.4
12.7
21
16
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
9.4
12.7
26
31
NDL99
NOMESCO Finland
Other operation on muscle or tendon of wrist or hand
+∞
12.6
12
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
12.6
12
*
P01BA02
ATC
hydroxychloroquine; oral
11.6
12.6
23
22
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
137.9
12.6
13
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
11.0
11.8
22
22
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
24.6
11.8
16
7
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
+∞
10.5
10
*
L04AA13
ATC
leflunomide; oral
+∞
10.5
10
*
73799
ICD-8 Finland
Hallux valgus and varus
+∞
10.5
10
*
R4120
NOMESCO Finland
Occupational therapy
6.2
10.4
28
51
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
27.5
9.9
13
5
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.9
9.8
27
51
L88
ICPC
Rheumatoid/seropositive arthritis
23.0
9.5
13
6
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
+∞
9.4
9
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
9.4
9
*
M79.6
ICD-10 Finland
Pain in limb
2.7
9.2
79
384
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
38.5
9.1
11
*
N03AX12
ATC
gabapentin; oral
3.7
9.0
41
130
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
52.2
8.7
10
*
NDL32
NOMESCO Finland
Suture or reinsertion of tendon of wrist or hand, extensor tendon
28.8
8.6
11
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
13.5
8.5
14
11
7362A
ICD-9 Finland
Other acquired deformities of limbs, Other acquired deformities of finger[DEFORMATIO BOUTONNIôRE]
+∞
8.4
8
*
T92.5
ICD-10 Finland
Sequelae of injury of muscle and tendon of upper limb
+∞
8.4
8
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
8.3
96
543
X58
ICD-10 Finland
Exposure to other specified factors
3.7
8.3
37
115
M01AH05
ATC
etoricoxib; oral
2.3
8.0
116
730
N03AX16
ATC
pregabalin; oral
2.9
8.0
54
226
N02AX02
ATC
tramadol; systemic, rectal
2.4
7.9
89
494
H02AB06
ATC
prednisolone; systemic
2.3
7.8
98
573
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
46.7
7.8
9
*
NDM99
NOMESCO Finland
Other operation on fascia, ganglion, synovial sheath or bursa of wrist or hand
46.7
7.8
9
*
S18
ICPC
Laceration/cut
2.3
7.6
89
503
NF1AA
NOMESCO Finland
Hip X-ray examination
8.2
7.5
16
21
ZXA00
NOMESCO Finland
Right side
2.7
7.5
59
268
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
82.9
7.5
8
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
82.9
7.5
8
*
WX320
NOMESCO Finland
Spinalanesthesy
3.2
7.4
41
149
ZXA05
NOMESCO Finland
Left side
2.7
7.4
56
247
M01AX05
ATC
glucosamine; oral
3.4
7.4
36
120
L04AX01
ATC
azathioprine; systemic
7.8
7.3
16
22
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
7.3
7
*
T92.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of upper limb
31.2
7.2
9
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
31.2
7.2
9
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.3
7.2
37
129
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.7
7.1
52
226
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
6.7
94
568
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
12.8
6.7
11
9
L12
ICPC
Hand/finger symptom/complaint
3.1
6.6
37
137
M24.4
ICD-10 Finland
Recurrent dislocation and subluxation of joint
71.9
6.5
7
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
14.9
6.5
10
7
N06AA09
ATC
amitriptyline; systemic
3.9
6.4
25
70
NDL62
NOMESCO Finland
Shortening of tendon of hand
+∞
6.3
6
*
NDL54
NOMESCO Finland
Tenolysis of hand
+∞
6.3
6
*
NF1DA
NOMESCO Finland
X-ray of hips
27.6
6.3
8
*
TQW40
NOMESCO Finland
Remowal of suture of skin
4.3
6.2
22
56
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
6.2
66
350
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
5.1
6.1
18
38
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
6.1
60
307
M01AX17
ATC
nimesulide; oral
2.5
6.0
51
239

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
128
856
2.14
7.24
8.5
4.7
0.0
0.0
e9/l
0.48
119
723
131
890
2.12
7.04
8.5
5.1
0.2
0.2
e9/l
0.01
123
767
127
856
2.10
6.93
8.4
4.7
0.6
0.6
e9/l
0.77
119
719
129
880
2.09
6.76
8.4
4.7
1.8
2.0
e9/l
0.69
120
763
91
549
2.10
6.60
8.1
4.8
—
—
—
0
0
71
392
2.18
6.45
2.3
2.4
330.4
11847.4
umol/l
3.16
63
348
45
215
2.36
5.71
1.4
1.1
30.1
1.5
u/ml
0.59
14
84
46
222
2.35
5.70
1.8
2.0
—
—
—
0
0
163
1259
2.06
5.55
7.1
3.2
13.0
11.1
mm/h
0.77
154
1141
47
233
2.28
5.47
1.4
1.2
59.7
13.7
iu/ml
1.15
22
80
36
162
2.45
5.19
1.6
1.2
408.0
398.7
titre
—
10
30
117
823
1.87
5.10
9.9
4.7
58.2
57.4
%
0.30
111
768
118
836
1.86
5.00
9.2
4.9
27.1
27.7
%
0.24
112
774
112
784
1.85
4.90
9.2
4.7
0.6
0.7
%
1.17
106
721
61
353
2.00
4.73
1.8
1.5
1.6
1.0
mg/l
0.68
45
265
93
645
1.75
3.98
4.2
3.4
16.4
32.7
ng/l
1.75
61
448
35
175
2.18
3.96
1.5
1.6
—
—
—
0
0
150
1195
1.76
3.86
6.3
3.7
—
—
—
0
0
133
1026
1.72
3.83
11.1
9.4
4.3
4.1
e9/l
0.33
127
877
169
1396
1.84
3.82
4.0
3.8
15.3
14.8
pmol/l
1.02
154
1262
75
494
1.78
3.81
4.5
3.6
—
—
—
0
0
38
200
2.08
3.77
3.6
2.3
119.3
108.9
ug/g
0.14
32
160
29
137
2.28
3.75
1.4
2.5
82.7
68.9
e9/l
1.03
21
100
202
1795
2.18
3.34
19.3
12.6
21.9
24.6
mg/l
0.52
173
1367
80
555
1.68
3.30
2.8
2.3
57.9
56.4
u/l
0.08
74
511
105
798
1.59
2.94
5.3
5.7
1.2
1.2
mmol/l
0.10
95
723
23
110
2.21
2.90
1.8
2.5
4.3
3.9
e9/l
0.38
14
90
41
248
1.80
2.71
1.1
1.2
—
—
—
0
0
93
704
1.55
2.56
11.9
7.2
1.3
1.2
inr
0.38
24
214
25
131
2.02
2.52
1.1
1.2
—
—
—
0
0
162
1388
1.59
2.52
10.4
7.4
75.8
78.4
u/l
0.50
156
1300
97
745
1.53
2.49
5.3
4.7
35.8
35.7
g/l
0.09
88
691
16
70
2.38
2.47
1.9
1.8
—
—
—
0
0
8
22
3.73
2.38
1.3
1.4
—
—
—
0
0
110
878
1.49
2.30
5.2
3.2
0.0
0.0
estimate
0.00
19
147
26
144
1.91
2.26
5.8
7.9
—
—
—
0
0
50
337
1.62
2.23
1.4
1.3
2.1
2.3
g/l
0.47
30
202
27
154
1.86
2.16
4.5
3.6
2.1
2.3
mmol/l
0.28
21
120
51
354
1.57
2.01
1.6
1.7
268293058.6
442.3
pmol/l
0.49
41
295
116
954
1.44
1.99
6.1
6.7
9.5
11.4
umol/l
2.53
110
910
37
238
1.66
1.98
1.6
1.6
—
—
—
0
0
32
199
1.71
1.93
1.5
1.3
—
—
—
0
0
27
160
1.78
1.92
4.4
3.6
—
—
—
0
0
53
375
1.54
1.92
6.2
4.5
—
—
—
0
0
209
1951
1.95
1.92
16.3
11.7
—
—
—
0
0
187
1695
1.60
1.91
5.3
4.4
1.9
2.6
mu/l
0.52
170
1539
21
115
1.91
1.90
1.1
1.4
—
—
—
0
0
17
87
2.03
1.85
5.2
8.0
—
—
—
0
0
124
1042
1.42
1.84
5.2
4.5
6.8
6.7
mmol/l
0.23
117
966
105
859
1.42
1.80
5.2
3.2
0.0
0.0
estimate
0.00
19
156
211
1984
1.96
1.76
21.4
14.8
77.1
77.2
umol/l
0.00
211
1984
32
205
1.65
1.74
2.8
2.3
12.2
8.6
umol/l
0.26
26
176
70
535
1.45
1.74
2.6
2.2
—
—
—
0
0
67
508
1.45
1.73
3.9
2.9
—
—
—
0
0
5
13
3.91
1.72
1.4
1.3
—
—
—
0
0
53
386
1.49
1.67
6.5
3.4
—
—
—
0
0
105
870
1.39
1.63
7.0
4.4
0.0
0.0
estimate
0.00
20
157
53
388
1.48
1.63
1.2
1.2
4.5
1.3
u/ml
0.35
13
108
10
43
2.39
1.62
1.2
1.1
—
—
—
0
0
195
1804
1.59
1.61
4.2
3.8
1.3
1.3
mmol/l
0.14
179
1650
61
463
1.43
1.56
5.6
3.4
0.0
0.0
estimate
0.00
18
152
7
27
2.64
1.52
1.1
1.1
—
—
—
0
0
7
27
2.64
1.52
1.0
1.0
—
—
—
0
0
23
140
1.72
1.52
1.2
1.4
—
—
—
0
0
16
87
1.90
1.50
4.6
3.2
24.9
25.1
mmol/l
0.06
16
87
87
707
1.37
1.49
1.8
1.9
89.9
95.9
pmol/l
0.39
42
363
15
80
1.94
1.48
3.3
2.6
1.3
1.2
%
0.06
15
80
5
16
3.17
1.44
1.6
1.4
—
—
—
0
0
16
89
1.86
1.41
4.1
3.3
—
—
—
0
0
11
53
2.13
1.41
2.0
3.2
—
—
—
0
0
51
382
1.43
1.39
6.8
3.5
1.0
1.0
kg/l
—
6
45
15
82
1.89
1.39
2.9
2.4
—
—
—
0
0
9
41
2.24
1.38
1.1
1.1
—
—
—
0
0
9
41
2.24
1.38
1.0
1.1
—
—
—
0
0
24
152
1.65
1.38
4.0
6.8
1.1
1.4
mmol/l
1.23
24
146
16
90
1.84
1.37
1.6
1.2
—
—
—
0
0
19
113
1.74
1.37
2.3
2.6
—
—
—
0
0
5
17
2.98
1.36
1.2
1.0
—
—
—
0
0
97
812
1.34
1.35
11.1
7.7
0.0
0.0
e9/l
0.48
88
650
56
708
0.72
1.30
3.0
2.8
—
—
—
0
0
29
198
1.53
1.25
1.7
1.6
—
—
—
0
0
62
490
1.37
1.24
4.0
2.1
205.1
185.8
u/l
0.09
57
466
57
445
1.38
1.23
8.8
7.2
—
—
—
0
0
75
615
1.33
1.18
3.9
3.4
16.7
62.3
e6/l
2.18
60
429
8
40
2.04
1.13
1.5
2.3
—
—
—
0
0
39
290
1.42
1.11
1.9
1.8
—
—
—
0
0
47
362
1.38
1.10
2.4
2.4
3.7
7.4
e6/l
0.87
39
310
62
499
1.33
1.10
3.8
2.7
0.2
0.6
e6/l
0.93
53
355
202
1920
1.49
1.05
5.5
4.7
2.8
2.8
mmol/l
0.09
186
1768
5
22
2.30
1.04
4.0
2.8
4.2
4.0
mmol/l
—
5
22
5
22
2.30
1.04
4.0
2.8
—
—
—
0
0
5
22
2.30
1.04
4.0
2.8
109.0
104.9
mmol/l
—
5
22
25
173
1.50
1.03
2.1
4.6
—
—
—
0
0
31
225
1.44
1.01
2.8
2.4
2.3
2.3
g/l
0.00
31
211
7
35
2.03
1.01
2.7
2.0
—
—
—
0
0
57
459
1.32
1.00
5.8
3.8
—
—
—
0
0
65
536
1.30
0.97
4.4
4.0
7.4
7.4
ph
—
9
96
6
28
2.17
0.92
1.5
1.4
—
—
—
0
0
6
28
2.17
0.92
1.3
1.5
—
—
—
0
0
7
126
0.54
0.91
1.3
1.5
—
—
—
0
0
44
348
1.33
0.88
3.1
2.5
539.1
546.0
mosm/kgh2o
0.07
37
293
6
31
1.96
0.85
4.0
2.8
6.5
8.2
mmol/l
—
6
31
6
31
1.96
0.85
1.0
1.2
—
—
—
0
0
65
545
1.27
0.85
3.7
2.9
178.9
53.5
e6/l
0.36
58
404
30
225
1.38
0.83
5.2
6.6
105.5
104.0
mmol/l
1.13
30
217
196
1869
1.37
0.83
4.9
4.2
1.5
1.5
mmol/l
0.01
180
1716
6
32
1.90
0.82
1.0
1.0
—
—
—
0
0
6
34
1.79
0.77
1.2
3.1
34.1
30.6
umol/l
—
6
27
6
34
1.79
0.77
4.0
2.6
1.3
1.5
mmol/l
—
6
34
17
116
1.50
0.77
3.9
4.0
—
—
—
0
0
58
486
1.26
0.76
1.9
1.6
1.4
1.4
mmol/l
0.09
49
401
15
100
1.54
0.75
1.4
1.2
—
—
—
0
0
7
38
1.87
0.74
1.3
1.0
—
—
—
0
0
27
204
1.37
0.73
5.4
7.1
0.4
1.2
mmol/l
0.74
19
158
87
766
1.22
0.73
3.3
2.5
152.5
129.4
ug/l
0.32
80
700
59
498
1.25
0.73
3.2
2.7
—
—
—
0
0
9
57
1.60
0.72
1.3
2.2
2012.7
238.3
ug/l
—
9
52
141
1305
1.21
0.70
3.9
3.6
—
—
—
0
0
208
2013
1.42
0.69
14.3
9.1
26.3
25.7
u/l
0.23
202
1933
20
145
1.42
0.68
5.3
3.7
—
—
—
0
0
12
78
1.57
0.67
2.0
2.9
—
—
—
0
0
21
155
1.39
0.66
1.6
1.4
—
—
—
0
0
196
1884
1.30
0.65
5.1
4.2
4.7
4.7
mmol/l
0.16
182
1745
8
50
1.62
0.62
2.8
4.5
35.6
41.4
mg/l
—
8
42
8
50
1.62
0.62
2.6
4.5
32.9
25.9
mg/l
—
8
43
8
50
1.62
0.62
4.1
4.2
—
—
—
0
0
181
1727
1.24
0.61
20.8
13.1
38.6
40.2
%
1.23
121
1271
0
20
0.00
0.60
0.0
2.9
—
—
—
0
0
13
179
0.71
0.52
1.3
1.5
—
—
—
0
0
24
189
1.30
0.52
1.7
1.7
—
—
—
0
0
9
64
1.42
0.52
8.4
9.5
—
—
—
0
0
10
67
1.52
0.50
4.9
4.8
—
—
—
0
0
11
153
0.70
0.47
1.3
1.3
—
—
—
0
0
36
303
1.22
0.47
1.6
1.6
970.1
1230.8
nmol/l
1.42
25
227
82
744
1.16
0.47
2.0
2.1
—
—
—
0
0
16
207
0.76
0.45
1.2
1.4
—
—
—
0
0
55
485
1.18
0.44
3.7
2.7
—
—
—
0
0
190
1840
1.20
0.43
5.0
4.2
5.8
5.9
mmol/l
1.69
172
1683
13
96
1.38
0.42
2.5
2.7
—
—
—
0
0
5
33
1.53
0.41
3.6
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
276.8
—
0
11
5
34
1.48
0.40
1.2
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
6
41
1.48
0.36
1.0
1.2
—
—
—
0
0
179
1736
1.15
0.33
6.4
5.4
39.1
39.9
mmol/mol
0.72
167
1607
6
46
1.31
0.33
3.3
1.5
—
—
—
0
0
12
93
1.31
0.30
1.7
1.6
—
—
—
0
0
46
414
1.14
0.29
1.7
1.5
21.2
21.1
nmol/l
0.02
36
347
58
532
1.12
0.28
4.4
3.1
6.6
7.5
mmol/l
1.40
48
450
66
613
1.11
0.26
5.7
4.9
2.0
3.2
ug/l
1.20
57
551
26
228
1.16
0.24
5.8
5.2
1.0
1.0
mmol/l
0.36
21
211
5
38
1.32
0.23
26.6
2.1
—
—
—
0
0
21
241
0.86
0.22
1.1
1.3
—
—
—
0
0
38
345
1.12
0.22
4.8
3.7
304.2
272.0
ng/l
0.04
28
265
5
42
1.19
0.21
1.4
1.2
4.2
9.3
u/l
—
5
35
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
17
145
1.19
0.21
1.1
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
2.0
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
10.5
—
0
13
6
48
1.26
0.20
1.2
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
238.1
—
0
9
18
206
0.86
0.19
2.2
4.6
4.3
23.5
ug/l
0.93
12
185
7
63
1.11
0.17
1.0
1.2
—
—
—
0
0
7
63
1.11
0.17
2.7
3.8
3.8
3.9
mmol/l
—
7
57
8
69
1.17
0.16
1.0
1.1
—
—
—
0
0
56
530
1.08
0.15
4.1
4.1
3.9
8.2
mg/mmol
1.24
31
343
53
501
1.08
0.14
3.5
3.2
1657.4
314.3
mg/l
0.37
25
325
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
19
206
0.92
0.09
1.3
1.5
—
—
—
0
0
35
369
0.94
0.09
3.4
2.8
0.6
0.8
ug/l
1.52
21
246
6
54
1.11
0.09
3.3
1.5
—
—
—
0
0
6
57
1.05
0.08
3.3
1.5
—
—
—
0
0
6
57
1.05
0.08
3.3
1.5
—
—
—
0
0
6
57
1.05
0.08
3.3
1.5
—
—
—
0
0
7
66
1.06
0.08
1.7
3.0
—
—
—
0
0
53
517
1.03
0.04
1.4
1.4
—
—
—
0
0
15
141
1.07
0.03
3.7
3.2
—
—
—
0
0
161
1600
1.02
0.02
26.7
16.4
332.0
332.7
g/l
0.44
161
1595
61
606
1.01
0.00
1.9
3.9
2.3
2.4
mmol/l
0.88
49
531
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
5.8
—
10.6
—
0
6
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
6.3
—
45.3
—
0
7
0
7
0.00
0.00
0.0
10.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
6
65
0.92
0.00
1.2
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
57
0.87
0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
9.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_FINGERDEFORM and mortality.

Females

Parameter HR [95% CI] p-value
M13_FINGERDEFORM 1.24 [0.96, 1.6] 0.096
Birth year 0.999 [0.99, 1.01] 0.752

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 690 females with M13_FINGERDEFORM died.

Males

Parameter HR [95% CI] p-value
M13_FINGERDEFORM 1.117 [0.87, 1.43] 0.381
Birth year 0.991 [0.98, 1.0] 0.189

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 494 males with M13_FINGERDEFORM died.

Mortality risk

Mortality risk for people of age

years, who have M13_FINGERDEFORM.

N-year risk Females Males
1 0.155% 0.254%
5 0.81% 1.674%
10 2.038% 3.989%
15 3.924% 7.081%
20 6.915% 11.933%

Relationships between endpoints

Index endpoint: M13_FINGERDEFORM – Deformity of finger(s)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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