synovitis: ['Inflammation of the SYNOVIAL MEMBRANE [ MeSH ]']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
147 |
4. Check minimum number of eventsNone |
147 |
5. Include endpointsNone |
147 |
6. Filter based on genotype QC (FinnGen only) |
147 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M65
- Name in latin
- [Teno]synovitis infectiosa
Similar endpoints
↥List of similar endpoints to
Other infective (teno)synovitis
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1009 | 530 | 477 |
| Only index persons | 967 | 512 | 455 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.52 | 51.73 | 49.28 |
| Only index persons | 50.64 | 51.52 | 49.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 147 | 93 | 54 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 52.56 | 50.28 | 56.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 133
- Matched controls
- 1329
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M65.1
ICD-10 Finland
Other infective (teno)synovitis
+∞
186.1
131
*
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
+∞
19.2
18
*
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
41.2
14.9
18
5
G56.0
ICD-10 Finland
Carpal tunnel syndrome
7.1
14.5
38
71
M79.6
ICD-10 Finland
Pain in limb
4.5
13.2
57
189
M25.5
ICD-10 Finland
Pain in joint
4.1
11.9
56
198
ZXA00
NOMESCO Finland
Right side
4.3
11.8
52
173
N03AX16
ATC
pregabalin; oral
4.4
10.9
45
139
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
22.1
10.0
14
7
NDS00
NOMESCO Finland
Incision and debridement of infection of tendon of wrist or hand
+∞
9.5
9
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
8.1
9.5
21
30
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.2
9.4
69
334
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
21.8
8.6
12
6
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.1
8.2
34
103
L03.0
ICD-10 Finland
Cellulitis of finger and toe
7.0
7.9
19
31
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
7.8
63
310
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
47.8
7.8
9
*
X59
ICD-10 Finland
Exposure to unspecified factor
3.8
7.6
34
110
N02BE01
ATC
paracetamol; systemic, rectal
4.4
7.6
121
928
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
5.2
7.5
23
51
H02AB06
ATC
prednisolone; systemic
2.8
7.5
70
376
NBG10
NOMESCO Finland
Acromioplastia
84.5
7.5
8
*
M65.0
ICD-10 Finland
Abscess of tendon sheath
+∞
7.4
7
*
M65.3
ICD-10 Finland
Trigger finger
13.0
7.2
12
10
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
10.9
7.2
13
13
M19.0
ICD-10 Finland
Primary arthrosis of other joints
6.0
7.1
19
36
N02AX02
ATC
tramadol; systemic, rectal
2.7
6.8
60
306
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
6.6
50
233
M13.9
ICD-10 Finland
Arthritis, unspecified
5.8
6.6
18
35
NDL52
NOMESCO Finland
Tenosynovectomy of hand
73.2
6.5
7
*
A02BC03
ATC
lansoprazole; oral
2.9
6.5
45
200
Z3226
NOMESCO Finland
Physiotherapist
3.4
6.4
32
113
M01AE03
ATC
ketoprofen; systemic, rectal
2.7
6.4
58
300
J01DB01
ATC
cefalexin; oral
3.1
6.4
113
854
A02BC02
ATC
pantoprazole; systemic
2.6
6.2
91
610
M76.6
ICD-10 Finland
Achilles tendinitis
10.8
6.2
11
11
ACC51
NOMESCO Finland
Release of median nerve
5.6
6.1
17
34
R52.9
ICD-10 Finland
Pain, unspecified
5.9
6.1
16
30
Mortality – FinRegistry
↥Association
Association between endpoint M13_INFTENOSYNOVITIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_INFTENOSYNOVITIS | 1.32 [0.99, 1.76] | 0.057 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 406 males with M13_INFTENOSYNOVITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_INFTENOSYNOVITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.255% |
| 5 | No data | 1.532% |
| 10 | No data | 3.809% |
| 15 | No data | 7.078% |
| 20 | No data | 11.844% |
Relationships between endpoints
↥Index endpoint: M13_INFTENOSYNOVITIS – Other infective (teno)synovitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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