synovitis: ['Inflammation of the SYNOVIAL MEMBRANE [ MeSH ]']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
147 |
4. Check minimum number of eventsNone |
147 |
5. Include endpointsNone |
147 |
6. Filter based on genotype QC (FinnGen only) |
147 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M65
- Name in latin
- [Teno]synovitis infectiosa
Similar endpoints
↥List of similar endpoints to
Other infective (teno)synovitis
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1009 | 530 | 477 |
| Only index persons | 967 | 512 | 455 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.52 | 51.73 | 49.28 |
| Only index persons | 50.64 | 51.52 | 49.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 147 | 93 | 54 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 52.56 | 50.28 | 56.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 133
- Matched controls
- 1329
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M65.1
ICD-10 Finland
Other infective (teno)synovitis
+∞
186.1
131
*
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
+∞
19.2
18
*
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
41.2
14.9
18
5
G56.0
ICD-10 Finland
Carpal tunnel syndrome
7.1
14.5
38
71
M79.6
ICD-10 Finland
Pain in limb
4.5
13.2
57
189
M25.5
ICD-10 Finland
Pain in joint
4.1
11.9
56
198
ZXA00
NOMESCO Finland
Right side
4.3
11.8
52
173
N03AX16
ATC
pregabalin; oral
4.4
10.9
45
139
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
22.1
10.0
14
7
NDS00
NOMESCO Finland
Incision and debridement of infection of tendon of wrist or hand
+∞
9.5
9
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
8.1
9.5
21
30
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.2
9.4
69
334
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
21.8
8.6
12
6
M75.1
ICD-10 Finland
Rotator cuff syndrome
4.1
8.2
34
103
L03.0
ICD-10 Finland
Cellulitis of finger and toe
7.0
7.9
19
31
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
7.8
63
310
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
47.8
7.8
9
*
X59
ICD-10 Finland
Exposure to unspecified factor
3.8
7.6
34
110
N02BE01
ATC
paracetamol; systemic, rectal
4.4
7.6
121
928
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
5.2
7.5
23
51
H02AB06
ATC
prednisolone; systemic
2.8
7.5
70
376
NBG10
NOMESCO Finland
Acromioplastia
84.5
7.5
8
*
M65.0
ICD-10 Finland
Abscess of tendon sheath
+∞
7.4
7
*
M65.3
ICD-10 Finland
Trigger finger
13.0
7.2
12
10
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
10.9
7.2
13
13
M19.0
ICD-10 Finland
Primary arthrosis of other joints
6.0
7.1
19
36
N02AX02
ATC
tramadol; systemic, rectal
2.7
6.8
60
306
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
6.6
50
233
M13.9
ICD-10 Finland
Arthritis, unspecified
5.8
6.6
18
35
NDL52
NOMESCO Finland
Tenosynovectomy of hand
73.2
6.5
7
*
A02BC03
ATC
lansoprazole; oral
2.9
6.5
45
200
M01AE03
ATC
ketoprofen; systemic, rectal
2.7
6.4
58
300
J01DB01
ATC
cefalexin; oral
3.1
6.4
113
854
A02BC02
ATC
pantoprazole; systemic
2.6
6.2
91
610
M76.6
ICD-10 Finland
Achilles tendinitis
10.8
6.2
11
11
ACC51
NOMESCO Finland
Release of median nerve
5.6
6.1
17
34
R52.9
ICD-10 Finland
Pain, unspecified
5.9
6.1
16
30
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
43
163
3.32
9.16
1.4
1.2
22.8
8.9
u/ml
0.48
17
68
42
174
2.98
7.57
1.4
1.2
28.7
31.8
iu/ml
0.10
12
64
53
272
2.48
6.14
2.9
2.8
362.7
8887.8
umol/l
2.06
46
232
79
493
2.30
5.79
6.0
5.9
1.2
1.2
mmol/l
0.25
73
443
141
1207
5.12
5.68
21.6
11.8
25.9
23.4
mg/l
0.38
122
919
116
863
2.63
5.56
5.7
3.4
12.2
11.3
mm/h
0.30
110
781
121
919
2.79
5.56
8.9
7.0
82.4
79.3
u/l
0.27
113
854
71
432
2.24
5.43
2.0
1.8
92.7
97.1
pmol/l
0.31
36
216
97
674
2.29
5.32
9.4
9.4
4.4
4.0
e9/l
0.73
85
601
83
547
2.19
5.12
7.6
6.9
1.2
1.2
mmol/l
0.03
73
468
10
22
4.80
4.37
1.4
1.1
10.8
1.2
u/ml
—
5
10
94
675
2.09
4.36
4.4
4.4
6.8
6.7
mmol/l
0.17
87
628
115
911
2.21
3.86
3.9
3.7
14.5
14.7
pmol/l
0.34
104
820
44
250
2.08
3.77
1.6
1.5
1.1
1.1
mg/l
0.03
31
194
79
554
1.92
3.69
5.8
3.2
0.0
0.0
estimate
0.00
17
91
78
550
1.89
3.53
7.6
4.5
0.0
0.0
estimate
0.00
17
98
84
611
1.87
3.41
5.8
6.2
11.7
11.0
umol/l
0.28
79
585
57
367
1.90
3.38
2.2
2.1
55.8
57.1
u/l
0.11
52
335
9
19
4.97
3.29
1.8
1.4
—
—
—
0
0
69
479
1.83
3.19
3.4
2.5
216.5
114.0
ug/l
0.45
63
435
9
22
4.29
2.93
2.1
1.6
—
—
—
0
0
76
555
1.76
2.89
5.6
3.1
0.0
0.0
estimate
0.00
15
97
5
6
8.57
2.77
1.0
1.0
—
—
—
0
0
6
10
6.20
2.72
1.0
1.7
—
—
—
0
0
10
32
3.28
2.70
1.2
1.5
—
—
—
0
0
31
180
1.92
2.44
1.7
1.6
1117.5
1168.0
nmol/l
0.11
26
129
9
27
3.48
2.44
1.7
1.4
—
—
—
0
0
8
22
3.78
2.40
1.0
1.1
—
—
—
0
0
127
1118
2.00
2.21
5.0
4.4
1.9
1.9
mu/l
0.00
120
1011
27
155
1.91
2.19
2.7
2.1
13.7
13.5
umol/l
0.04
27
144
53
373
1.66
2.17
2.7
3.5
2.4
2.4
mmol/l
0.12
45
334
6
15
4.12
2.06
1.2
1.0
—
—
—
0
0
54
392
1.60
1.91
4.7
2.8
—
—
—
0
0
33
211
1.73
1.90
1.4
1.5
—
—
—
0
0
10
40
2.61
1.88
1.2
1.2
3.3
3.4
g/l
—
5
27
10
40
2.61
1.88
1.2
1.2
—
—
—
0
0
133
1206
2.08
1.87
4.7
4.2
1.4
1.5
mmol/l
1.40
125
1114
5
12
4.27
1.84
1.2
1.1
—
—
—
0
0
19
103
1.97
1.82
5.4
3.0
—
—
—
0
0
135
1235
2.14
1.78
5.3
4.7
2.8
2.8
mmol/l
0.45
127
1140
131
1187
1.95
1.76
4.7
4.2
6.0
5.9
mmol/l
0.21
124
1097
133
1215
1.99
1.68
5.0
4.3
4.7
4.8
mmol/l
0.56
125
1133
31
202
1.68
1.66
5.7
3.4
1341.9
295.0
ng/l
0.47
22
159
125
1125
1.74
1.60
6.8
5.3
39.7
39.4
mmol/mol
0.13
120
1051
27
172
1.70
1.57
5.1
2.4
3.6
2.6
e6/l
0.30
18
83
21
125
1.79
1.54
2.4
2.4
—
—
—
0
0
7
27
2.67
1.53
3.6
2.9
—
—
—
0
0
6
21
2.93
1.52
1.0
1.5
—
—
—
0
0
36
250
1.58
1.51
1.4
1.2
3.0
1.2
u/ml
—
9
60
57
439
1.49
1.49
4.6
3.3
74.1
31.8
ng/l
0.57
41
288
57
440
1.48
1.47
6.2
3.2
—
—
—
0
0
11
56
2.04
1.25
2.4
1.3
—
—
—
0
0
19
117
1.72
1.25
2.3
2.2
—
—
—
0
0
66
538
1.41
1.23
7.5
3.9
—
—
—
0
0
8
38
2.17
1.20
1.3
1.2
8.3
9.2
g/l
—
8
31
5
20
2.55
1.16
1.4
1.5
—
—
—
0
0
20
128
1.65
1.16
5.8
7.7
12.9
12.4
kpa
0.14
20
123
20
128
1.65
1.16
5.8
7.7
5.0
5.2
kpa
0.40
20
122
11
58
1.97
1.15
4.4
6.3
23.6
25.5
mmol/l
0.92
11
58
34
248
1.48
1.14
1.3
1.4
17.3
21.0
nmol/l
0.93
29
209
5
21
2.43
1.10
1.2
9.5
—
156.6
—
0
5
7
34
2.11
1.04
1.1
1.2
—
—
—
0
0
38
291
1.41
0.99
7.4
3.3
0.0
0.0
estimate
0.50
17
95
12
70
1.78
0.96
6.1
7.9
24.0
24.6
mmol/l
0.23
12
64
6
27
2.27
0.94
4.2
2.0
23.7
25.7
mmol/l
—
6
18
38
296
1.38
0.90
3.9
3.2
2407.4
1043.7
ng/l
0.73
32
249
16
106
1.57
0.83
5.4
8.8
120.4
122.8
g/l
0.14
16
101
137
1308
1.70
0.83
14.0
9.3
27.9
26.3
u/l
0.54
132
1261
10
58
1.78
0.82
1.1
1.5
—
—
—
0
0
11
66
1.72
0.81
7.4
9.0
0.5
0.7
%
0.73
11
66
125
1175
1.43
0.77
4.4
3.8
1.4
1.3
mmol/l
0.94
116
1084
6
34
1.80
0.77
1.7
1.3
—
—
—
0
0
84
748
1.29
0.76
3.1
3.1
—
—
—
0
0
91
820
1.29
0.74
3.6
2.8
46.5
48.6
u/l
0.11
84
769
5
25
2.03
0.73
1.6
1.8
—
—
—
0
0
9
58
1.59
0.71
1.6
1.9
—
—
—
0
0
16
113
1.47
0.64
1.8
1.9
—
—
—
0
0
16
114
1.45
0.62
2.0
1.9
—
—
—
0
0
11
72
1.57
0.61
1.5
1.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
4.3
—
0
12
8
53
1.54
0.59
1.4
2.3
28.8
42.2
u/l
—
8
47
37
306
1.28
0.58
4.2
2.8
0.2
0.6
e6/l
1.26
30
224
6
35
1.74
0.58
1.0
1.4
1.3
1.2
g/l
—
6
29
9
63
1.46
0.53
1.1
1.0
—
—
—
0
0
34
283
1.26
0.51
3.9
2.2
—
—
—
0
0
10
67
1.53
0.51
8.0
8.9
1.4
1.6
%
—
10
67
11
76
1.48
0.49
8.0
2.8
117.1
92.6
ng/l
0.27
11
67
7
48
1.48
0.47
1.3
1.8
—
—
—
0
0
21
166
1.31
0.46
2.0
1.9
—
—
—
0
0
5
31
1.63
0.43
1.2
1.1
—
—
—
0
0
5
31
1.63
0.43
2.0
1.6
32.6
38.0
nmol/l
—
5
31
5
31
1.63
0.43
1.2
1.1
—
—
—
0
0
5
34
1.49
0.41
1.0
1.2
40.6
38.4
g/l
—
5
26
14
109
1.31
0.35
1.8
1.9
0.3
0.2
g/l
0.56
14
103
120
1156
1.21
0.34
18.2
11.3
79.0
83.2
ml/min/173m2
1.11
95
937
118
1136
1.20
0.33
19.7
13.1
38.0
40.3
%
1.10
75
840
5
39
1.29
0.23
1.6
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
13.1
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
18.3
—
0
13
6
48
1.26
0.20
1.0
1.3
40.8
28.1
iu/l
—
6
43
21
184
1.16
0.20
3.5
2.3
1.0
1.2
e6/l
0.06
13
94
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
18
206
0.86
0.19
1.4
1.4
—
—
—
0
0
26
234
1.13
0.18
1.9
1.7
384.9
445.4
pmol/l
0.72
20
208
23
254
0.89
0.16
4.0
4.2
22.7
21.4
%
0.15
12
110
19
171
1.13
0.13
2.4
1.7
28.2
29.4
s
0.62
19
164
15
144
1.05
0.00
15.7
7.2
—
—
—
0
0
14
146
0.95
0.00
3.6
4.3
32.6
32.6
%
—
7
95
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
6
61
0.98
0.00
4.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.5
—
1536.3
—
0
6
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
115.2
—
0
5
7
75
0.93
0.00
3.7
2.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_INFTENOSYNOVITIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_INFTENOSYNOVITIS | 1.32 [0.99, 1.76] | 0.057 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 406 males with M13_INFTENOSYNOVITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_INFTENOSYNOVITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.255% |
| 5 | No data | 1.532% |
| 10 | No data | 3.809% |
| 15 | No data | 7.078% |
| 20 | No data | 11.844% |
Relationships between endpoints
↥Index endpoint: M13_INFTENOSYNOVITIS – Other infective (teno)synovitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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