synovitis: ['Inflammation of the SYNOVIAL MEMBRANE [ MeSH ]']
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
156 |
4. Check minimum number of eventsNone |
156 |
5. Include endpointsNone |
156 |
6. Filter based on genotype QC (FinnGen only) |
149 |
Control definitions (FinnGen only)
- Control exclude
- M13_SOFTTISSUE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M65
- Name in latin
- [Teno]synovitis infectiosa
Similar endpoints
↥List of similar endpoints to
Other infective (teno)synovitis
based on the number of shared cases.
Similar with more cases:
- Disorders of synovium and tendon
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1009 | 530 | 477 |
| Only index persons | 967 | 512 | 455 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 50.52 | 51.73 | 49.28 |
| Only index persons | 50.64 | 51.52 | 49.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 149 | 92 | 57 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 53.94 | 51.94 | 57.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 156
- Matched controls
- 1560
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M65.1
ICD-10 Finland
Other infective (teno)synovitis
+∞
219.5
154
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
6.8
22.8
43
83
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
254.2
22.2
22
*
M79.6
ICD-10 Finland
Pain in limb
4.0
16.7
82
337
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
7.8
15.3
23
34
N03AX16
ATC
[U] pregabalin
4.2
15.3
54
174
L03.0
ICD-10 Finland
Cellulitis of finger and toe
6.5
14.9
27
49
ACC51
NOMESCO Finland
Release of median nerve
7.3
14.5
23
36
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
20.0
14.3
21
12
M13.9
ICD-10 Finland
Arthritis, unspecified
7.1
14.2
23
37
NDS00
NOMESCO Finland
Incision and debridement of infection of tendon of wrist or hand
+∞
13.7
13
*
M25.5
ICD-10 Finland
Pain in joint
3.6
13.7
67
268
X59
ICD-10 Finland
Exposure to unspecified factor
4.1
13.1
46
146
M19.0
ICD-10 Finland
Primary arthrosis of other joints
6.0
13.0
25
48
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
38.2
11.5
14
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.2
11.2
25
55
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
5.7
10.9
22
44
ZXA00
NOMESCO Finland
Right side
3.3
10.7
56
228
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
18.3
10.1
15
9
R4120
NOMESCO Finland
Occupational therapy
5.6
9.9
20
40
N02AX02
ATC
tramadol; systemic, rectal
2.9
9.8
76
383
M65.3
ICD-10 Finland
Trigger finger
13.6
9.6
16
13
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
+∞
9.5
9
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.5
9.4
38
131
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.8
9.3
85
464
R52.9
ICD-10 Finland
Pain, unspecified
4.6
8.9
23
57
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
5.3
8.8
19
40
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.7
8.7
81
443
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
13.8
8.6
14
11
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
13.8
8.6
14
11
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
10.3
8.5
16
17
M65.0
ICD-10 Finland
Abscess of tendon sheath
+∞
8.4
8
*
J01FF01
ATC
clindamycin; systemic
2.9
8.4
51
223
H02AB06
ATC
prednisolone; systemic
2.7
8.3
85
483
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.3
8.2
19
29
Z3226
NOMESCO Finland
Physiotherapist
3.2
7.8
36
134
A46
ICD-10 Finland
Erysipelas
3.4
7.3
30
103
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
12.9
7.2
12
10
A02BC02
ATC
pantoprazole; systemic
2.7
7.1
114
784
M01AE03
ATC
ketoprofen; systemic, rectal
2.5
7.0
70
387
L12
ICPC
Hand/finger symptom/complaint
3.0
6.9
34
131
L04AX03
ATC
methotrexate; systemic
3.8
6.9
22
64
NBG10
NOMESCO Finland
Acromioplastia
41.9
6.8
8
*
M54.5
ICD-10 Finland
Low back pain
2.5
6.7
59
305
L08
ICPC
Shoulder symptom/complaint
2.9
6.7
36
145
M48.0
ICD-10 Finland
Spinal stenosis
3.6
6.6
23
71
N06AX21
ATC
duloxetine; oral
3.6
6.6
23
71
M79.0
ICD-10 Finland
Rheumatism, unspecified
72.7
6.5
7
*
QCB05
NOMESCO Finland
Revision of wound of skin of upper limb
27.9
6.3
8
*
NDL52
NOMESCO Finland
Tenosynovectomy of hand
27.9
6.3
8
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.2
6.2
27
96
M01AH01
ATC
celecoxib; oral
2.9
6.1
32
127
W22
ICD-10 Finland
Striking against or struck by other object(s)
4.3
6.1
16
40
ZXD05
NOMESCO Finland
Urgent procedure
2.4
6.1
58
310
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
178
3.35
10.04
1.4
1.2
21.62
10.95
u/ml
0.36
18
75
47
185
3.20
9.36
1.3
1.2
31.04
29.69
iu/ml
0.04
15
67
56
284
2.52
6.66
2.9
2.8
360.39
8433.79
umol/l
2.06
49
245
86
531
2.38
6.58
13.9
10.7
1.25
1.10
inr
0.72
20
150
150
1277
5.54
6.35
22.2
11.7
25.91
23.51
mg/l
0.39
129
968
123
904
2.70
6.22
6.3
3.4
12.07
11.15
mm/h
0.32
117
819
128
964
2.83
6.08
9.6
7.1
82.23
78.61
u/l
0.35
120
898
82
513
2.26
5.88
5.9
5.8
1.22
1.22
mmol/l
0.20
76
464
75
457
2.23
5.68
1.9
1.8
91.58
96.30
pmol/l
0.35
39
235
87
567
2.21
5.53
7.4
6.8
1.22
1.22
mmol/l
0.00
77
486
101
716
2.16
4.99
9.9
9.2
4.42
3.96
e9/l
1.00
89
638
99
708
2.09
4.63
4.4
4.3
6.78
6.76
mmol/l
0.04
92
660
46
255
2.14
4.21
1.6
1.6
1.04
1.11
mg/l
0.05
33
196
10
18
5.86
4.04
1.7
1.4
—
—
—
0
0
11
23
5.06
3.95
2.5
1.6
—
—
—
0
0
89
637
1.92
3.88
6.2
6.4
11.71
11.07
umol/l
0.27
84
611
103
778
1.95
3.78
6.0
3.7
—
5046.91
—
0
11
10
20
5.26
3.75
1.4
1.1
10.80
1.11
u/ml
—
5
9
60
380
1.94
3.75
2.2
2.1
56.35
69.46
u/l
0.51
55
349
74
514
1.84
3.41
3.4
2.4
211.76
110.46
ug/l
0.49
68
470
119
964
1.99
3.31
3.8
3.7
14.53
14.67
pmol/l
0.28
107
871
80
574
1.81
3.28
5.8
3.1
0.00
0.00
estimate
-0.00
17
93
79
571
1.78
3.11
7.5
4.3
0.00
0.00
estimate
-0.00
17
101
5
6
8.55
2.77
1.0
1.0
—
—
—
0
0
6
10
6.19
2.72
1.0
1.7
—
—
—
0
0
29
161
1.98
2.58
2.7
2.1
13.69
13.74
umol/l
0.01
29
153
5
7
7.33
2.56
1.0
1.0
—
—
—
0
0
5
7
7.33
2.56
1.0
1.0
—
—
—
0
0
5
7
7.33
2.56
1.0
1.0
—
—
—
0
0
9
26
3.61
2.52
1.7
1.4
—
—
—
0
0
7
16
4.53
2.50
2.6
2.1
—
—
—
0
0
77
577
1.66
2.49
5.8
3.1
0.00
0.00
estimate
-0.00
18
106
10
33
3.17
2.40
1.1
1.5
—
—
—
0
0
8
23
3.61
2.30
1.0
1.1
—
—
—
0
0
32
192
1.84
2.26
1.7
1.6
1087.48
1173.43
nmol/l
0.22
27
138
18
88
2.18
2.22
1.3
3.2
65.87
67.46
g/l
0.43
18
76
133
1176
1.89
2.11
5.0
4.4
1.91
1.94
mu/l
0.08
125
1066
6
15
4.11
2.06
1.2
1.0
—
—
—
0
0
61
448
1.59
2.05
4.5
3.2
68.42
30.70
ng/l
0.56
45
295
51
359
1.62
2.04
3.7
3.7
10.27
8.69
mg/mmol
0.10
36
221
7
21
3.44
1.99
1.9
1.4
—
—
—
0
0
139
1255
1.99
1.95
4.6
4.2
6.00
5.90
mmol/l
0.27
132
1163
23
130
1.90
1.94
2.3
2.4
—
—
—
0
0
55
400
1.58
1.90
2.6
3.4
2.35
2.36
mmol/l
0.07
49
361
8
28
2.95
1.89
4.8
2.9
—
—
—
0
0
5
12
4.27
1.83
1.4
1.8
—
—
—
0
0
133
1192
1.79
1.80
6.6
5.2
39.89
39.32
mmol/mol
0.30
127
1116
33
214
1.69
1.79
5.5
3.4
1283.83
279.74
ng/l
0.48
23
168
73
573
1.51
1.77
4.1
2.5
—
—
—
0
0
19
104
1.94
1.76
5.3
3.0
—
—
—
0
0
5
13
3.93
1.73
1.2
1.1
—
—
—
0
0
140
1280
1.91
1.68
4.6
4.2
1.43
1.50
mmol/l
1.45
132
1187
55
410
1.53
1.68
4.7
2.7
—
—
—
0
0
6
19
3.24
1.68
1.0
1.1
—
—
—
0
0
10
43
2.41
1.62
1.2
1.3
—
—
—
0
0
10
43
2.41
1.62
1.2
1.3
6.95
7.21
g/l
—
10
37
10
43
2.41
1.62
1.2
1.3
3.70
3.24
g/l
—
10
37
10
44
2.36
1.59
1.9
2.3
0.70
1.84
ug/l
—
10
36
142
1311
1.93
1.55
5.2
4.7
2.74
2.85
mmol/l
0.65
134
1213
140
1289
1.84
1.51
4.9
4.2
4.67
4.78
mmol/l
0.60
132
1205
37
258
1.57
1.51
1.4
1.2
2.97
1.19
u/ml
—
9
60
37
259
1.56
1.48
1.3
1.4
18.98
20.38
nmol/l
0.23
32
219
12
59
2.12
1.48
4.2
6.2
23.94
25.39
mmol/l
0.65
12
59
20
120
1.76
1.42
2.3
2.2
—
—
—
0
0
21
129
1.73
1.38
5.6
7.7
5.09
5.18
kpa
0.17
21
123
21
129
1.73
1.38
5.6
7.6
12.75
12.38
kpa
0.12
21
124
27
178
1.63
1.38
5.1
2.4
3.61
2.66
e6/l
0.28
18
88
33
229
1.56
1.37
1.4
1.5
—
—
—
0
0
5
17
3.00
1.37
1.6
2.7
110.20
80.57
u/ml
—
5
17
5
17
3.00
1.37
1.4
1.6
—
—
—
0
0
41
301
1.49
1.32
3.8
3.1
2343.59
1045.38
ng/l
0.71
33
253
12
62
2.01
1.31
1.6
1.2
211.34
498.44
u/ml
0.31
12
54
124
1121
1.52
1.28
24.7
14.3
15.06
14.83
%
0.19
124
1106
58
458
1.42
1.28
6.2
3.1
—
—
—
0
0
8
41
2.00
1.10
1.3
1.3
8.27
9.59
g/l
—
8
34
11
59
1.93
1.10
2.4
1.3
—
—
—
0
0
5
21
2.42
1.10
1.2
9.8
—
156.60
—
0
5
5
21
2.42
1.10
1.4
1.7
—
—
—
0
0
12
67
1.86
1.08
6.9
9.0
94.32
93.20
%
0.34
12
67
7
33
2.17
1.07
1.1
1.2
—
—
—
0
0
12
68
1.83
1.04
6.9
8.8
0.59
0.72
%
0.50
12
68
12
69
1.80
0.99
6.1
8.0
24.00
24.68
mmol/l
0.24
12
64
39
300
1.40
0.98
7.3
3.3
0.00
0.01
estimate
0.50
17
98
6
27
2.27
0.94
1.5
1.8
—
—
—
0
0
6
29
2.11
0.90
4.2
2.0
23.67
25.65
mmol/l
—
6
29
145
1385
1.67
0.84
14.4
9.4
27.86
26.30
u/l
0.58
139
1337
16
109
1.52
0.74
1.7
1.9
0.24
0.22
g/l
0.33
16
103
7
41
1.74
0.71
1.0
1.3
2.43
2.67
g/l
—
7
35
17
119
1.48
0.70
1.9
1.9
—
—
—
0
0
17
119
1.48
0.70
1.8
1.8
—
—
—
0
0
11
69
1.64
0.70
7.5
8.8
1.67
1.61
%
0.06
11
69
132
1248
1.38
0.70
4.3
3.8
1.38
1.29
mmol/l
0.82
123
1154
89
802
1.26
0.68
3.0
3.0
—
—
—
0
0
12
78
1.58
0.68
1.5
1.5
—
—
—
0
0
10
63
1.63
0.63
1.1
1.5
—
—
—
0
0
10
63
1.63
0.63
1.5
1.9
—
—
—
0
0
37
303
1.29
0.62
4.1
2.4
—
—
—
0
0
8
50
1.63
0.62
1.3
1.7
—
—
—
0
0
95
869
1.24
0.61
4.3
2.9
46.66
48.09
u/l
0.07
88
817
23
176
1.36
0.61
2.1
1.9
—
—
—
0
0
8
53
1.54
0.59
1.4
2.3
28.75
43.41
u/l
—
8
47
6
35
1.74
0.58
1.7
1.3
—
—
—
0
0
6
38
1.60
0.55
1.0
1.5
1.35
1.61
g/l
—
6
32
129
1228
1.29
0.54
18.1
11.0
79.85
83.41
ml/min/173m2
0.95
102
994
38
321
1.24
0.50
4.1
2.7
0.21
0.60
e6/l
1.44
31
236
11
77
1.46
0.47
8.0
2.7
117.09
94.25
ng/l
0.25
11
67
5
31
1.63
0.43
1.6
1.7
—
—
—
0
0
8
56
1.45
0.43
7.0
9.8
25.00
24.89
mmol/l
—
8
56
5
32
1.58
0.42
2.0
1.6
32.60
37.16
nmol/l
—
5
32
5
32
1.58
0.42
1.8
1.7
—
—
—
0
0
5
34
1.49
0.40
1.2
1.1
—
—
—
0
0
5
34
1.49
0.40
1.2
1.1
—
—
—
0
0
9
66
1.39
0.39
1.1
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
5.05
—
0
10
6
41
1.48
0.36
3.3
3.7
24.83
24.97
mmol/l
—
6
41
17
137
1.27
0.33
5.3
7.0
106.00
104.66
mmol/l
0.58
17
137
20
169
1.21
0.27
2.3
1.8
27.82
29.37
s
0.85
20
161
28
245
1.17
0.27
1.9
1.7
412.77
435.02
pmol/l
0.19
22
218
5
37
1.36
0.24
1.0
1.2
40.64
38.75
g/l
—
5
31
5
40
1.26
0.22
1.6
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
13.13
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
17.84
—
0
14
25
275
0.89
0.16
4.2
4.2
23.62
21.18
%
0.32
13
120
21
193
1.10
0.10
3.5
2.3
1.04
1.14
e6/l
0.06
13
102
5
48
1.04
0.09
1.6
1.7
—
—
—
0
0
6
58
1.04
0.08
1.0
1.3
40.85
27.01
iu/l
—
6
52
7
80
0.87
0.07
3.7
2.1
—
—
—
0
0
21
223
0.93
0.06
1.4
1.5
—
—
—
0
0
15
156
0.96
0.00
3.5
4.2
31.50
32.31
%
—
8
104
10
99
1.01
0.00
6.7
2.5
57.00
65.73
ml/min/173m2
—
5
37
15
152
0.99
0.00
15.6
7.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
1536.33
—
0
6
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
52
0.96
-0.00
2.6
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
73.60
—
0
5
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
6
65
0.92
-0.00
4.0
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
111.17
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint M13_INFTENOSYNOVITIS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_INFTENOSYNOVITIS | 1.32 [0.99, 1.76] | 0.057 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 406 males with M13_INFTENOSYNOVITIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_INFTENOSYNOVITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.255% |
| 5 | No data | 1.532% |
| 10 | No data | 3.809% |
| 15 | No data | 7.078% |
| 20 | No data | 11.844% |
Relationships between endpoints
↥Index endpoint: M13_INFTENOSYNOVITIS – Other infective (teno)synovitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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