Other specified acquired deformities of limbs

M13_LIMBDEFORM

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M21.8, M21.9
  • Hospital discharge: ICD-9 736[8-9]
  • Cause of death: ICD-10 M21.8, M21.9
  • Cause of death: ICD-9 736[8-9]

2 out of 7 registries used, show all original rules.

181

4. Check minimum number of events

None

181

5. Include endpoints

None

181

6. Filter based on genotype QC (FinnGen only)

175

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1624 978 639
Only index persons 1493 897 596
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 32.12 39.17 21.06
Only index persons 31.42 38.34 21.00

-FinnGen-

Key figures

All Female Male
Number of individuals 175 118 57
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 41.72 42.25 40.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
181
Matched controls
1810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.8
ICD-10 Finland
Other specified acquired deformities of limbs
+∞
90.4
79
*
M21.9
ICD-10 Finland
Acquired deformity of limb, unspecified
+∞
58.6
53
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
29.0
55.2
39
17
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
20.4
43.0
35
21
7368X
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformities of other parts of limbs
+∞
42.4
39
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
22.3
21
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
68.7
21.5
24
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
20.2
19
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
19.1
18
*
WX320
NOMESCO Finland
Spinalanesthesy
4.7
18.8
56
159
M20.1
ICD-10 Finland
Hallux valgus (acquired)
24.9
17.4
24
11
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.7
16.7
96
427
M19.0
ICD-10 Finland
Primary arthrosis of other joints
27.6
16.4
22
9
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
+∞
15.9
15
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
7.3
15.8
25
39
M25.5
ICD-10 Finland
Pain in joint
3.9
15.8
64
225
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
13.6
15.7
27
23
9115
FHL
Epiphysiodesis (in hip luxation trokanter 9408)
+∞
14.8
14
*
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
14.8
14
*
WX702
NOMESCO Finland
Supraglottic ventilation device
6.6
13.9
24
41
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
13.7
13
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
43.6
13.4
16
*
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
43.6
13.4
16
*
B01AB05
ATC
enoxaparin; parenteral
3.4
13.2
64
249
L15
ICPC
Knee symptom/complaint
3.7
12.8
50
169
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
+∞
12.6
12
*
M79.6
ICD-10 Finland
Pain in limb
3.1
12.6
89
431
N02AX02
ATC
tramadol; systemic, rectal
3.1
12.4
80
367
X59
ICD-10 Finland
Exposure to unspecified factor
3.6
12.1
50
175
7369X
ICD-9 Finland
Other acquired deformities of limbs, Acquired deformity of limb, site unspecified
+∞
11.6
11
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
18.6
11.4
17
10
J01FF01
ATC
clindamycin; systemic
3.1
11.0
61
254
ZXA05
NOMESCO Finland
Left side
3.3
11.0
51
191
M16.1
ICD-10 Finland
Other primary coxarthrosis
17.4
10.6
16
10
9271
FHL
Hallux surgery
+∞
10.5
10
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.8
10.4
85
435
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
10.0
9.8
19
21
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.8
9.6
23
53
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
23.2
9.5
13
6
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
11.6
9.0
16
15
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
7.6
8.8
20
29
NE1AA
NOMESCO Finland
Pelvis X-ray examination
8.6
8.6
18
23
9102
FHL
Trepanation or removal of the local bone process
21.3
8.6
12
6
N03AX16
ATC
[U] pregabalin
3.0
8.5
46
186
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
94.3
8.5
9
*
M20.2
ICD-10 Finland
Hallux rigidus
94.3
8.5
9
*
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
8.4
8
*
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
+∞
8.4
8
*
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
15.4
8.3
13
9
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.9
8.3
26
74
N03AX12
ATC
[U] gabapentin; oral
3.5
8.2
32
106
M01AH05
ATC
etoricoxib; oral
2.5
8.2
111
702
NH3EA
NOMESCO Finland
Feet X-ray examination with load
35.1
8.2
10
*
NF1AA
NOMESCO Finland
Hip X-ray examination
7.6
8.0
18
26
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.3
7.7
32
110
H02AB06
ATC
prednisolone; systemic
2.4
7.6
82
463
L17
ICPC
Foot/toe symptom/complaint
2.5
7.4
58
283
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
4.8
7.3
17
38
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
+∞
7.3
7
*
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
+∞
7.3
7
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
+∞
7.3
7
*
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
+∞
7.3
7
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
7.3
7
*
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
31.4
7.2
9
*
ZXD20
NOMESCO Finland
Day surgery
3.2
7.2
32
115
M01AB05
ATC
diclofenac; systemic, rectal
2.4
7.2
119
805
M01AH01
ATC
celecoxib; oral
3.3
7.1
30
104
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
6.6
7.0
17
28
S18
ICPC
Laceration/cut
2.3
6.9
82
478
WX002
NOMESCO Finland
Sedation and analgesia
2.9
6.5
34
134
WX704
NOMESCO Finland
Intubation
3.8
6.4
20
57
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
18.8
6.3
9
5
WX212
NOMESCO Finland
Femoral plexus blockade
18.8
6.3
9
5
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
6.3
6
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
6.3
6
*
WX213
NOMESCO Finland
Lower leg blockade
+∞
6.3
6
*
M21.5
ICD-10 Finland
Acquired clawhand, clubhand, clawfoot and clubfoot
+∞
6.3
6
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
6.3
6
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
27.7
6.3
8
*
NF1DA
NOMESCO Finland
X-ray of hips
27.7
6.3
8
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
27.7
6.3
8
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
6.3
35
143
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.5
6.2
47
224
X58
ICD-10 Finland
Exposure to other specified factors
3.0
6.1
29
108
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.8
6.1
19
54

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
81
505
2.09
5.49
3.4
4.9
36.92
36.21
g/l
0.59
75
476
17
48
3.81
5.47
1.2
1.0
—
—
—
0
0
35
160
2.47
4.96
1.5
1.1
31.98
1.35
u/ml
—
9
70
90
613
1.93
4.52
7.1
6.9
1.23
1.22
mmol/l
0.35
73
518
35
167
2.36
4.51
1.3
1.2
10.34
16.76
iu/ml
1.21
12
50
30
144
2.30
3.80
1.8
2.0
—
—
—
0
0
124
978
1.85
3.59
4.2
3.2
10.97
9.63
mm/h
0.52
117
893
127
1016
1.84
3.43
6.0
7.3
75.36
78.50
u/l
0.38
118
953
118
926
1.79
3.38
3.1
3.3
—
—
—
0
0
59
390
1.76
3.01
3.7
4.0
7.41
7.39
ph
—
9
73
12
37
3.40
3.00
2.1
4.0
—
—
—
0
0
36
204
1.95
2.98
2.0
1.6
1269.70
1101.12
nmol/l
0.40
25
151
134
1126
1.73
2.66
4.2
3.8
15.04
14.61
pmol/l
1.27
123
1044
5
7
7.30
2.56
1.0
1.0
21.58
39.26
mg/l
—
5
7
25
131
2.05
2.56
2.3
1.7
—
—
—
0
0
76
559
1.62
2.53
6.3
6.7
1.23
1.22
mmol/l
0.11
71
510
25
133
2.02
2.46
1.6
1.5
—
—
—
0
0
46
299
1.72
2.44
3.1
3.9
—
—
—
0
0
64
460
1.61
2.30
2.5
3.4
18.77
35.23
ng/l
1.06
37
285
71
527
1.57
2.22
9.2
9.4
1.11
1.18
inr
0.38
24
168
15
68
2.31
2.18
4.4
9.5
24.11
24.78
mmol/l
0.21
15
68
43
284
1.67
2.14
3.3
2.8
325.54
9914.08
umol/l
2.02
37
255
38
244
1.71
2.10
1.9
1.7
458.97
428.81
pmol/l
0.26
30
214
86
676
1.52
2.03
4.4
7.5
9.34
12.24
umol/l
2.55
79
636
60
437
1.56
2.00
2.4
3.5
2.35
2.36
mmol/l
0.26
52
397
94
765
1.48
1.82
4.8
4.8
6.30
6.53
mmol/l
0.72
86
694
42
288
1.60
1.80
1.7
2.1
1.64
0.94
mg/l
0.52
35
216
6
19
3.23
1.67
1.2
1.2
—
—
—
0
0
41
286
1.56
1.63
1.9
1.8
2.71
3.12
mg/l
0.50
29
240
110
935
1.45
1.63
5.0
3.7
—
—
—
0
0
14
73
1.99
1.48
1.4
1.2
120.46
188.26
u/ml
0.59
14
65
5
120
0.40
1.43
1.4
1.4
—
—
—
0
0
9
42
2.20
1.36
16.7
14.9
—
—
—
0
0
82
678
1.38
1.33
6.4
4.5
0.00
0.01
estimate
0.50
16
120
33
231
1.52
1.29
2.1
2.8
2.43
2.43
mmol/l
0.08
28
210
82
684
1.36
1.24
4.1
3.2
0.00
0.00
estimate
-0.00
16
115
5
19
2.68
1.22
4.0
2.6
4.74
5.14
kpa
—
5
19
5
19
2.68
1.22
4.0
2.6
8.90
9.19
kpa
—
5
19
5
19
2.68
1.22
2.2
1.4
12.40
13.02
%
—
5
19
74
610
1.36
1.20
6.5
5.7
8.76
8.33
%
0.53
69
576
48
368
1.41
1.20
1.4
1.3
0.77
1.16
u/ml
—
6
88
19
119
1.67
1.17
3.8
3.4
—
—
—
0
0
14
80
1.81
1.16
1.9
2.1
—
—
—
0
0
73
603
1.35
1.16
6.4
5.5
2.85
2.73
%
0.16
68
569
5
20
2.54
1.16
1.0
1.1
—
—
—
0
0
34
246
1.47
1.15
2.8
3.6
22.52
289.88
ng/l
1.74
21
174
50
390
1.39
1.13
2.2
2.3
62.47
57.30
u/l
0.25
43
368
164
1547
1.64
1.13
12.8
10.1
—
—
—
0
0
164
1547
1.64
1.13
14.7
12.8
72.06
72.81
umol/l
0.12
164
1547
154
1434
1.50
1.12
14.3
11.4
23.44
22.95
mg/l
0.05
130
1062
72
597
1.34
1.11
6.1
6.2
—
—
—
0
0
71
588
1.34
1.10
6.4
5.4
0.67
0.68
%
0.05
65
548
51
403
1.37
1.06
2.8
3.0
9.46
56.19
e6/l
2.09
40
300
146
1350
1.42
1.06
5.2
4.4
1.73
2.73
mu/l
0.58
139
1248
46
358
1.38
1.05
2.5
3.0
0.21
0.39
e6/l
0.54
36
258
56
452
1.35
1.02
2.3
1.8
92.51
91.59
pmol/l
0.05
23
243
51
409
1.34
0.97
4.5
2.6
—
—
—
0
0
79
675
1.30
0.96
4.2
3.2
0.00
0.00
estimate
-0.00
18
124
48
382
1.35
0.95
2.5
2.7
—
—
—
0
0
75
637
1.30
0.95
6.3
5.5
27.20
28.09
%
0.29
70
607
6
28
2.18
0.92
1.2
1.8
—
—
—
0
0
46
366
1.34
0.92
2.9
3.2
8.62
7.55
mmol/l
0.64
36
316
14
214
0.63
0.89
1.2
1.4
—
—
—
0
0
40
314
1.35
0.87
3.2
3.1
127.34
295.24
mg/l
0.32
24
198
10
57
1.80
0.85
1.2
2.1
—
—
—
0
0
8
46
1.77
0.83
1.0
1.2
—
—
—
0
0
45
362
1.32
0.83
1.9
2.9
—
—
—
0
0
75
648
1.27
0.81
6.4
5.4
0.04
0.04
e9/l
0.04
62
554
73
632
1.26
0.77
6.2
5.3
58.41
57.35
%
0.34
68
600
75
652
1.26
0.76
2.7
2.5
76.19
92.34
ug/l
0.47
69
610
72
625
1.25
0.74
9.1
8.1
0.00
0.01
e9/l
0.68
58
496
74
645
1.25
0.73
6.4
5.4
0.56
0.55
e9/l
0.25
62
553
17
118
1.49
0.72
10.9
8.7
5.33
4.98
kpa
0.81
17
109
17
118
1.49
0.72
10.8
8.7
11.41
12.46
kpa
0.66
17
111
77
675
1.24
0.72
6.4
5.4
1.77
1.87
e9/l
0.55
67
597
14
93
1.55
0.72
12.1
12.9
—
—
—
0
0
40
324
1.30
0.71
1.3
1.4
1.90
2.18
g/l
0.79
20
204
10
61
1.68
0.70
13.5
12.3
0.70
0.69
%
—
10
61
10
61
1.68
0.70
13.5
12.3
1.37
1.79
%
—
10
61
23
171
1.40
0.70
1.2
1.2
—
—
—
0
0
55
467
1.26
0.67
3.3
3.5
62.02
86.01
e6/l
0.14
40
315
33
263
1.31
0.66
2.0
1.4
21.16
21.32
nmol/l
0.02
26
218
5
29
1.74
0.64
1.0
1.3
—
—
—
0
0
13
88
1.51
0.62
2.8
3.2
—
—
—
0
0
0
21
0.00
0.60
0.0
6.8
—
—
—
0
0
12
82
1.50
0.56
1.9
2.4
81.42
159.37
ng/l
1.15
12
75
162
1564
1.34
0.53
9.7
8.6
24.67
26.22
u/l
0.64
156
1514
6
39
1.56
0.53
2.7
6.6
—
—
—
0
0
9
63
1.45
0.53
1.2
1.6
—
—
—
0
0
75
673
1.20
0.53
6.5
5.8
0.18
0.18
e9/l
0.05
65
586
16
118
1.39
0.52
1.2
1.2
234.63
132.33
iu/ml
—
8
51
11
75
1.50
0.52
1.2
1.8
—
—
—
0
0
62
548
1.20
0.51
4.3
3.1
6.08
5.88
ph
—
6
50
18
136
1.36
0.51
1.2
1.1
—
—
—
0
0
9
65
1.40
0.51
1.0
1.5
—
—
—
0
0
12
165
0.71
0.49
1.3
1.8
—
—
—
0
0
141
1345
1.22
0.48
3.7
3.5
1.28
1.23
mmol/l
0.36
132
1246
40
341
1.22
0.47
3.8
3.4
—
—
—
0
0
11
77
1.46
0.46
1.8
2.4
64.40
72.88
e9/l
—
5
53
39
334
1.21
0.44
4.1
3.7
19.67
10.31
mg/mmol
0.30
21
211
17
217
0.76
0.44
1.4
1.8
—
—
—
0
0
16
205
0.76
0.43
2.1
1.5
—
—
—
0
0
10
70
1.45
0.42
1.5
2.8
—
—
—
0
0
11
79
1.42
0.42
1.2
1.8
—
—
—
0
0
11
80
1.40
0.39
1.2
1.8
—
—
—
0
0
18
143
1.29
0.38
1.4
1.4
—
—
—
0
0
32
371
0.83
0.37
2.1
2.0
—
—
—
0
0
6
88
0.67
0.34
1.0
1.2
—
—
—
0
0
40
354
1.17
0.33
3.6
3.3
0.00
0.01
estimate
0.50
17
118
170
1668
1.32
0.32
20.7
16.7
40.16
40.46
%
0.29
151
1576
7
52
1.36
0.31
1.6
1.2
—
—
—
0
0
24
204
1.20
0.30
2.2
1.6
—
—
—
0
0
12
150
0.79
0.28
1.2
1.2
—
—
—
0
0
38
341
1.14
0.26
2.2
1.6
1.28
1.33
mmol/l
0.15
31
289
40
362
1.13
0.25
6.7
7.5
—
—
—
0
0
10
78
1.30
0.24
1.1
1.8
—
—
—
0
0
6
83
0.71
0.24
1.0
1.1
—
—
—
0
0
20
171
1.19
0.24
1.2
1.3
—
—
—
0
0
5
37
1.36
0.23
2.0
2.4
—
—
—
0
0
10
79
1.28
0.23
1.2
1.8
—
—
—
0
0
10
124
0.80
0.22
1.2
1.6
—
—
—
0
0
144
1404
1.13
0.22
4.2
3.8
1.45
1.47
mmol/l
0.28
136
1300
5
41
1.23
0.22
6.6
1.3
0.22
0.24
g/l
—
5
41
0
11
0.00
0.21
0.0
5.9
—
13.38
—
0
11
0
11
0.00
0.21
0.0
8.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
73.54
—
0
13
13
108
1.22
0.20
1.7
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
2.7
—
22.75
—
0
8
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
586.86
—
0
14
6
50
1.21
0.20
1.0
1.7
—
—
—
0
0
11
90
1.24
0.19
1.1
1.4
—
—
—
0
0
14
119
1.19
0.18
1.4
2.7
1.74
1.68
%
0.15
14
112
7
59
1.19
0.18
2.7
4.7
24.14
24.77
mmol/l
—
7
59
8
69
1.17
0.16
2.5
4.4
—
—
—
0
0
144
1411
1.10
0.16
4.4
3.9
4.76
4.72
mmol/l
0.19
136
1313
146
1432
1.10
0.16
4.7
4.3
2.92
2.84
mmol/l
0.44
138
1324
59
559
1.08
0.16
2.2
2.6
—
—
—
0
0
9
79
1.15
0.15
1.1
1.2
—
—
—
0
0
140
1373
1.09
0.14
4.1
3.8
5.63
5.81
mmol/l
1.29
129
1260
44
417
1.07
0.11
2.7
2.2
—
—
—
0
0
80
774
1.06
0.11
8.2
10.0
3.80
4.16
e9/l
1.01
73
665
17
186
0.91
0.09
2.4
2.5
0.40
0.83
ug/l
—
9
108
17
185
0.91
0.08
2.6
3.4
29.62
30.33
s
0.28
17
180
7
63
1.12
0.08
6.1
4.0
—
—
—
0
0
12
108
1.12
0.07
5.7
4.9
—
—
—
0
0
9
84
1.08
0.07
2.8
4.3
—
7.41
—
0
10
9
102
0.88
0.06
2.6
2.2
10.89
9.89
g/l
—
9
96
59
575
1.04
0.05
1.8
2.0
—
—
—
0
0
10
110
0.90
0.05
6.6
9.0
9.54
7.20
mmol/l
—
10
103
11
120
0.91
0.05
5.9
5.9
—
—
—
0
0
20
208
0.96
0.02
3.4
2.7
0.73
2.69
e6/l
—
10
101
29
297
0.97
0.01
1.9
1.7
—
—
—
0
0
12
126
0.95
0.00
1.4
1.6
—
—
—
0
0
13
136
0.95
0.00
10.8
7.1
102.85
104.21
mmol/l
0.50
13
136
29
286
1.02
0.00
3.3
3.4
—
—
—
0
0
43
429
1.00
0.00
1.3
1.5
—
—
—
0
0
128
1281
1.00
0.00
5.1
4.8
37.90
38.69
mmol/mol
0.49
121
1192
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
14.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.87
-0.00
2.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
20.50
—
0
6
5
57
0.87
-0.00
4.0
4.6
0.64
0.65
%
—
5
57
0
8
0.00
-0.00
0.0
1.6
—
2031.25
—
0
8
6
62
0.97
-0.00
8.0
3.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
24.00
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
4.7
4.1
25.43
25.32
mmol/l
—
6
63
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
1091.86
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_LIMBDEFORM and mortality.

Females

Parameter HR [95% CI] p-value
M13_LIMBDEFORM 1.57 [1.14, 2.17] 0.006
Birth year 0.994 [0.99, 1.0] 0.203

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 621 females with M13_LIMBDEFORM died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_LIMBDEFORM.

N-year risk Females Males
1 0.187% No data
5 0.894% No data
10 2.358% No data
15 4.271% No data
20 7.636% No data

Relationships between endpoints

Index endpoint: M13_LIMBDEFORM – Other specified acquired deformities of limbs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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