Female pelvic inflammatory disorders in diseases classified elsewhere

N14_FEMPELINFINOTH

Pelvic Inflammatory Disease: Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N74*
  • Cause of death: ICD-10 N74*

2 out of 7 registries used, show all original rules.

143

4. Check minimum number of events

None

143

5. Include endpoints

None

143

6. Filter based on genotype QC (FinnGen only)

138

Control definitions (FinnGen only)

Control exclude
N14_FEMALEGENINF

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1114 1114 -
Only index persons 1099 1099 -
Unadjusted period prevalence (%)
Whole population 0.03 0.03 -
Only index persons 0.04 0.04 -
Median age at first event (years)
Whole population - 23.59 -
Only index persons - 23.53 -

-FinnGen-

Key figures

All Female Male
Number of individuals 138 138 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 24.80 24.80 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
143
Matched controls
1430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N74.4*A56.1
ICD-10 Finland
Female chlamydial pelvic inflammatory disease
+∞
149.4
116
*
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
44.0
28.0
34
10
P01AB01
ATC
metronidazole; oral, rectal
6.2
23.6
104
430
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
44.9
21.6
26
7
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
5.2
20.4
60
174
A56.1
ICD-10 Finland
Chlamydial infection of pelviperitoneum and other genitourinary organs
+∞
20.3
19
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.6
17.2
96
441
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
4.4
17.2
83
344
N70.0
ICD-10 Finland
Acute salpingitis and oophoritis
178.7
15.8
16
*
N06AB05
ATC
paroxetine; oral
5.6
11.2
23
47
N76.0
ICD-10 Finland
Acute vaginitis
4.2
10.7
33
95
N02AX02
ATC
tramadol; systemic, rectal
3.2
10.6
65
294
N74.4
ICD-10 Finland
Female chlamydial pelvic inflammatory disease
+∞
10.5
10
*
N70.1
ICD-10 Finland
Chronic salpingitis and oophoritis
+∞
10.5
10
*
M77.1
ICD-10 Finland
Lateral epicondylitis
4.8
10.1
25
60
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.4
9.7
45
170
N71.9
ICD-10 Finland
Inflammatory disease of uterus, unspecified
23.6
9.5
13
6
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.0
9.5
90
512
J01AA02
ATC
doxycycline; systemic
4.0
9.3
120
811
M79.6
ICD-10 Finland
Pain in limb
2.9
9.1
79
425
TLC00
NOMESCO Finland
Insertion of intrauterine device
3.6
8.7
33
109
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
3.2
8.5
42
164
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
8.4
25
69
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
3.6
8.3
32
107
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
3.1
8.0
41
163
R10.0
ICD-10 Finland
Acute abdomen
10.2
7.5
14
15
D73
ICPC
Gastroenteritis presumed infection
4.4
7.4
20
51
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.9
7.4
45
196
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
+∞
7.3
7
*
N05AH04
ATC
quetiapine; oral
2.8
7.2
47
212
SPAT1240
SPAT
Therapeutic discussion
3.0
7.1
39
160
JAH01
NOMESCO Finland
Laparoscopy
7.8
6.9
15
21
R51.80
ICD-10 Finland
Headache
2.8
6.8
45
204
L29
ICD-10 Finland
Pruritus
23.8
6.8
9
*
Z72.0
ICD-10 Finland
Tobacco use
10.8
6.7
12
12
O60
ICD-10 Finland
Preterm labour and delivery
4.3
6.7
18
46
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
3.1
6.6
32
122
W19
ICD-10 Finland
Unspecified fall
4.4
6.4
17
43
LCH11
NOMESCO Finland
Pharmacologic abortion
3.4
6.3
25
84
N70.9
ICD-10 Finland
Salpingitis and oophoritis, unspecified
+∞
6.3
6
*
TLC02
NOMESCO Finland
Simple extraction of IUD
4.0
6.3
19
53
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.8
6.2
38
165
SPAT1263
SPAT
Sampling
2.4
6.1
75
452
SPAT1283
SPAT
Restricted health certificate
2.4
6.1
58
312

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
58
256
3.13
9.68
2.1
2.0
47.96
54.93
u/l
1.51
50
240
79
447
2.71
7.93
3.1
4.8
8.09
9.11
umol/l
0.73
71
419
44
188
2.94
7.53
3.0
2.3
2625.34
5481.71
u/l
0.44
17
87
50
237
2.71
6.97
2.0
2.4
7.07
13.11
ng/l
2.16
15
76
62
336
2.49
6.49
2.5
2.1
—
—
—
0
0
33
153
2.50
4.64
2.0
3.2
—
—
—
0
0
132
1098
3.63
4.54
7.8
7.1
3.88
3.87
mmol/l
0.24
125
1049
9
16
5.92
3.72
1.7
1.4
—
—
—
0
0
83
593
1.95
3.72
3.9
2.9
0.00
0.00
estimate
-0.00
20
128
25
113
2.47
3.68
1.2
1.2
—
—
—
0
0
42
237
2.09
3.67
2.5
2.4
0.42
0.32
e6/l
0.15
30
173
82
585
1.94
3.67
5.2
4.0
0.00
0.00
estimate
-0.00
21
124
26
121
2.40
3.59
1.3
1.1
—
—
—
0
0
27
130
2.33
3.46
1.1
1.2
—
—
—
0
0
71
493
1.87
3.36
3.3
2.7
5.70
5.88
ph
—
5
47
33
176
2.14
3.31
2.8
2.5
—
—
—
0
0
42
248
1.98
3.21
2.6
2.3
—
—
—
0
0
43
258
1.95
3.13
10.5
6.5
0.96
1.04
inr
2.43
16
95
43
259
1.94
3.09
2.6
2.4
14.85
53.43
e6/l
0.92
32
189
81
597
1.82
3.08
3.9
3.0
0.00
0.00
estimate
-0.00
22
120
50
320
1.86
2.98
4.1
3.1
0.00
0.00
estimate
-0.00
20
123
120
1013
2.15
2.90
4.4
4.5
14.46
14.17
pmol/l
0.73
113
964
77
566
1.78
2.89
3.1
3.6
6.26
6.06
mmol/l
0.37
66
476
23
114
2.21
2.75
4.2
2.9
—
—
—
0
0
52
346
1.79
2.70
3.8
2.8
87.74
50.25
e6/l
0.18
32
206
9
26
3.62
2.53
1.0
1.2
—
—
—
0
0
13
51
2.70
2.52
1.3
1.7
—
—
—
0
0
95
761
1.74
2.48
4.9
5.7
70.80
69.99
u/l
0.08
85
717
101
836
1.71
2.21
3.4
3.1
7.82
7.88
mm/h
0.03
92
792
134
1231
2.41
2.04
7.6
7.1
21.20
22.44
u/l
0.52
127
1196
39
261
1.68
1.91
3.4
3.1
—
—
—
0
0
11
46
2.51
1.90
1.7
1.5
—
—
—
0
0
50
358
1.61
1.89
1.7
1.8
—
—
—
0
0
51
367
1.61
1.88
3.4
2.2
—
—
—
0
0
102
864
1.63
1.86
5.4
3.5
—
—
—
0
0
14
67
2.21
1.83
2.7
3.1
—
—
—
0
0
15
74
2.15
1.82
1.4
1.9
—
—
—
0
0
129
1171
2.04
1.77
5.1
5.0
1.49
1.65
mu/l
1.13
118
1120
35
232
1.67
1.77
1.5
1.5
—
—
—
0
0
43
302
1.61
1.74
1.4
1.3
1.99
2.07
g/l
0.17
21
191
47
342
1.56
1.63
1.3
1.3
0.61
1.21
u/ml
1.00
16
93
5
14
3.66
1.63
1.8
1.2
—
—
—
0
0
138
1304
2.67
1.59
10.4
8.2
—
—
—
0
0
116
1039
1.62
1.43
3.9
2.9
5.44
5.51
mmol/l
0.42
104
980
29
194
1.62
1.41
1.7
2.5
39.23
67.35
ug/g
1.21
20
149
115
1037
1.56
1.28
2.8
2.6
1.19
1.13
mmol/l
0.35
108
997
120
1094
1.60
1.25
3.2
2.9
4.83
4.74
mmol/l
0.60
112
1056
37
270
1.50
1.24
3.3
2.9
1.02
1.02
kg/l
—
5
43
17
102
1.76
1.23
1.3
1.5
—
—
—
0
0
12
65
1.92
1.17
2.8
2.1
—
—
—
0
0
8
39
2.11
1.17
2.0
1.3
—
—
—
0
0
129
1202
1.75
1.17
11.2
8.4
20.24
16.66
mg/l
0.66
113
889
18
112
1.69
1.15
1.5
1.9
—
—
—
0
0
60
488
1.40
1.13
2.2
1.8
—
—
—
0
0
43
330
1.43
1.12
2.7
4.4
1.24
1.22
mmol/l
1.26
35
312
37
276
1.46
1.11
1.7
1.7
0.38
0.73
mg/l
3.26
29
200
7
33
2.18
1.07
1.3
1.5
—
—
—
0
0
17
107
1.67
1.05
1.4
1.5
—
—
—
0
0
17
107
1.67
1.05
1.4
1.5
—
—
—
0
0
17
108
1.65
1.02
1.0
1.4
—
—
—
0
0
12
69
1.81
1.00
3.2
4.3
—
—
—
0
0
118
1088
1.48
0.99
3.2
2.9
1.49
1.53
mmol/l
0.61
109
1049
14
85
1.72
0.98
1.3
1.1
—
—
—
0
0
39
301
1.41
0.98
1.9
1.8
2.74
2.62
mg/l
0.14
33
268
20
135
1.56
0.95
1.5
1.5
—
—
—
0
0
16
102
1.64
0.95
1.3
1.2
—
—
—
0
0
6
27
2.27
0.94
4.0
1.9
12.83
13.48
%
—
6
27
29
213
1.45
0.94
1.3
1.3
21.16
22.08
nmol/l
0.11
23
194
6
29
2.11
0.90
1.5
1.9
—
—
—
0
0
101
913
1.36
0.89
4.2
3.4
36.91
36.47
mmol/mol
0.21
93
878
14
89
1.64
0.85
1.4
1.5
—
—
—
0
0
118
1098
1.43
0.84
3.4
3.0
2.91
2.84
mmol/l
0.39
109
1057
16
106
1.57
0.83
1.4
1.5
—
—
—
0
0
17
116
1.53
0.78
1.7
1.5
—
—
—
0
0
44
359
1.33
0.77
1.5
1.7
96.42
95.50
pmol/l
0.04
23
208
10
60
1.72
0.74
1.2
1.3
—
—
—
0
0
7
40
1.79
0.72
2.6
1.9
—
—
—
0
0
7
40
1.79
0.72
1.3
1.1
—
—
—
0
0
7
40
1.79
0.72
1.3
1.1
—
—
—
0
0
7
41
1.74
0.71
5.9
1.8
0.20
0.25
g/l
—
7
41
75
664
1.27
0.70
3.7
7.2
4.58
3.85
e9/l
1.85
68
586
41
336
1.31
0.70
3.3
3.8
36.75
37.59
g/l
0.45
35
318
5
27
1.88
0.69
1.0
1.1
—
—
—
0
0
17
120
1.47
0.68
1.0
1.2
—
—
—
0
0
11
71
1.60
0.64
1.1
1.2
—
—
—
0
0
8
49
1.67
0.63
1.3
1.7
—
—
—
0
0
31
248
1.32
0.62
1.4
1.3
9.49
32.88
iu/ml
—
8
71
37
304
1.29
0.62
2.2
2.6
2.36
2.34
mmol/l
0.38
30
282
9
131
0.67
0.55
1.3
1.4
—
—
—
0
0
23
181
1.32
0.52
1.7
1.4
177.14
545.71
titre
—
7
28
44
378
1.24
0.51
3.3
5.2
1.24
1.22
mmol/l
1.51
36
334
11
76
1.48
0.49
1.2
1.3
3.26
2.91
ug/l
0.16
11
70
7
46
1.55
0.49
1.3
1.8
—
—
—
0
0
60
537
1.20
0.46
3.8
4.8
2.98
2.70
%
0.35
53
510
11
78
1.44
0.44
4.8
4.0
0.99
1.00
mmol/l
0.06
11
72
60
539
1.19
0.44
4.2
5.0
7.11
7.58
%
0.65
54
513
8
59
1.38
0.41
1.4
1.6
0.40
0.47
nmol/l
—
8
49
14
106
1.36
0.41
1.2
1.6
—
—
—
0
0
63
572
1.18
0.40
3.8
5.1
0.53
0.51
e9/l
0.33
56
520
63
574
1.17
0.39
3.8
5.1
0.04
0.04
e9/l
0.42
57
518
62
565
1.17
0.38
4.0
4.7
30.62
30.49
%
0.03
55
541
59
537
1.17
0.36
4.1
5.3
—
—
—
0
0
6
42
1.45
0.36
1.3
1.0
—
—
—
0
0
11
82
1.37
0.35
1.2
1.2
—
—
—
0
0
56
511
1.16
0.33
3.7
4.9
0.66
0.63
%
0.19
50
478
51
463
1.16
0.32
2.6
2.0
—
—
—
0
0
29
252
1.19
0.30
1.4
1.3
1.00
8.50
u/ml
—
9
111
26
224
1.20
0.30
2.3
3.0
7.41
7.40
ph
—
9
35
29
253
1.18
0.29
1.5
1.5
1.83
1.34
mmol/l
0.41
24
227
17
204
0.81
0.29
1.2
1.2
—
—
—
0
0
8
63
1.29
0.28
3.0
6.4
106.00
105.90
mmol/l
—
8
63
56
520
1.13
0.25
1.8
1.7
—
—
—
0
0
13
106
1.25
0.24
1.5
1.2
—
—
—
0
0
5
38
1.33
0.23
1.0
2.0
5.30
5.11
kpa
—
5
38
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
22.8
—
2012.46
—
0
13
0
13
0.00
0.21
0.0
15.6
—
1018.08
—
0
13
12
143
0.82
0.19
2.0
1.6
—
—
—
0
0
27
244
1.13
0.18
1.5
2.3
—
—
—
0
0
13
152
0.84
0.18
1.2
1.4
—
—
—
0
0
5
65
0.76
0.17
1.0
1.3
—
—
—
0
0
13
151
0.85
0.16
1.2
1.4
—
—
—
0
0
59
561
1.09
0.15
3.7
4.5
56.38
55.99
%
0.09
53
535
29
266
1.11
0.15
3.7
5.6
—
—
—
0
0
8
95
0.83
0.14
1.0
1.1
—
—
—
0
0
53
508
1.07
0.11
7.4
7.0
0.00
0.00
e9/l
-0.00
44
421
5
43
1.17
0.10
1.0
2.0
5.96
5.55
kpa
—
5
43
50
521
0.94
0.10
1.9
1.8
—
—
—
0
0
14
155
0.89
0.09
1.2
1.5
—
—
—
0
0
5
47
1.07
0.09
1.0
1.3
—
—
—
0
0
64
621
1.06
0.08
2.4
2.0
—
—
—
0
0
18
170
1.07
0.04
4.1
4.3
2.59
12.81
mg/mmol
1.83
11
116
112
1131
0.96
0.04
11.1
10.9
332.39
332.15
g/l
0.11
112
1125
28
270
1.05
0.03
1.4
1.6
—
—
—
0
0
48
486
0.98
0.00
1.9
1.6
—
—
—
0
0
62
618
1.01
0.00
2.7
2.3
—
—
—
0
0
17
168
1.01
0.00
1.2
1.3
334.70
156.64
iu/ml
—
5
72
17
165
1.03
0.00
3.0
3.6
31.22
71.26
mg/l
0.82
11
116
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
8.80
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
77.88
—
0
8
9
89
1.01
-0.00
3.2
2.2
—
14.06
—
0
5
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
10.13
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
91.76
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
88.24
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
1.70
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
1.67
—
0
7
0
7
0.00
-0.00
0.0
2.7
—
1.29
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
560.75
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
30.83
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
6.20
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
7.18
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
24.50
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
27.43
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_FEMPELINFINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_FEMPELINFINOTH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: N14_FEMPELINFINOTH – Female pelvic inflammatory disorders in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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