Phlebitis and thrombophlebitis of lower extremities, unspecified, drug-induced

PHLEBI_THROMBOP_LOWER_EXTREMITI_UNSPE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 I80.3#

1 out of 7 registries used, show all original rules.

314

4. Check minimum number of events

None

314

5. Include endpoints

None

314

6. Filter based on genotype QC (FinnGen only)

314

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 314 174 140
Unadjusted period prevalence (%) 0.06 0.06 0.06
Median age at first event (years) 50.63 47.30 54.77

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
291
Matched controls
2911
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
+∞
323.0
291
44
B01AA03
ATC
warfarin; systemic
12.3
81.5
205
472
B01AB04
ATC
dalteparin; parenteral
11.9
33.0
63
66
M79.6
ICD-10 Finland
Pain in limb
3.5
21.8
146
653
B01AB05
ATC
enoxaparin; parenteral
3.5
21.5
138
595
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
10.4
20.7
41
45
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
8.5
16.8
37
49
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
19.1
15.4
23
13
D68.8
ICD-10 Finland
Other specified coagulation defects
56.2
14.0
16
*
K94
ICPC
Phlebitis/thrombophlebitis
22.5
13.5
19
9
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
13.3
58
173
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
12.4
13.1
23
20
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
10.8
12.7
24
24
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
17.3
11.8
18
11
I87.0
ICD-10 Finland
Postthrombotic syndrome
124.7
11.5
12
*
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
16.3
11.0
17
11
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
12.0
9.7
17
15
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
3.4
9.5
48
161
N02AX02
ATC
tramadol; systemic, rectal
2.2
9.4
143
892
J01DA01
ATC
[U] cefalexin; systemic
2.2
9.1
199
1444
K93
ICPC
Pulmonary embolism
13.3
8.5
14
11
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.2
8.4
31
80
ZXE00
NOMESCO Finland
One hour or less
2.1
8.1
130
813
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
7.6
7.3
16
22
N02AJ06
ATC
codeine and paracetamol; systemic
2.1
7.3
107
639
A46
ICD-10 Finland
Erysipelas
2.6
7.1
56
246
D01AC02
ATC
miconazole; topical
3.1
7.0
37
129
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
41.0
6.8
8
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
6.5
99
595
M01AH02
ATC
rofecoxib; oral
2.6
6.2
48
208
J01DB01
ATC
cefalexin; oral
2.0
6.1
231
1904

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: PHLEBI_THROMBOP_LOWER_EXTREMITI_UNSPE – Phlebitis and thrombophlebitis of lower extremities, unspecified, drug-induced

GWS hits: 1

This endpoint is excluded (not available in FinRegistry).