No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
210 |
4. Check minimum number of eventsNone |
210 |
5. Include endpointsNone |
210 |
6. Filter based on genotype QC (FinnGen only) |
201 |
Control definitions (FinnGen only)
- Control exclude
- AB1_INTESTINAL_INFECTIONS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Amoebiasis
based on the number of shared cases.
Similar with more cases:
- Amoebiasis
- Intestinal infectious diseases
- Intestinal infectious diseases
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2264 | 1163 | 1084 |
| Only index persons | 1862 | 978 | 884 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 35.75 | 39.01 | 31.87 |
| Only index persons | 35.28 | 37.77 | 32.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 201 | 118 | 83 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 43.46 | 45.69 | 40.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 210
- Matched controls
- 2100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A06.9
ICD-10 Finland
Amoebiasis, unspecified
+∞
75.7
68
*
A06.0
ICD-10 Finland
Acute amoebic dysentery
+∞
53.5
49
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
6.8
31.5
60
117
A06.1
ICD-10 Finland
Chronic intestinal amoebiasis
+∞
29.9
28
*
A06.8
ICD-10 Finland
Amoebic infection of other sites
+∞
24.4
23
*
P01AB01
ATC
metronidazole; oral, rectal
3.3
16.7
112
535
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.1
14.6
104
505
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
12.1
39
114
Z2221
NOMESCO Finland
Medical doctor
2.9
11.7
78
357
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
10.8
74
341
UJF32
NOMESCO Finland
Coloscopy
2.9
10.6
67
295
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
10.6
102
557
A06.4
ICD-10 Finland
Amoebic liver abscess
+∞
10.5
10
*
A07.8
ICD-10 Finland
Other specified protozoal intestinal diseases
+∞
10.5
10
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
8.8
101
586
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
10.7
8.7
16
16
00699
ICD-8 Finland
Amoebiasis, Without mention of liver abscess
+∞
8.4
8
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
+∞
8.4
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.1
8.3
38
138
AA1AD
NOMESCO Finland
CT of head and brain
2.6
8.3
62
294
A02BC05
ATC
esomeprazole; systemic
2.3
8.1
93
534
R06.0
ICD-10 Finland
Dyspnoea
2.5
8.0
67
335
R50.9
ICD-10 Finland
Fever, unspecified
2.8
7.5
43
177
00920
ICD-8 Finland
Diarrhoeal disease, Gastroenteritis (acuta) (infectiosa)
+∞
7.3
7
*
N30.0
ICD-10 Finland
Acute cystitis
2.8
7.3
42
174
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
7.3
42
174
UJF30
NOMESCO Finland
Ileoscopy through colon
3.4
7.2
27
87
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
6.5
88
530
H02AB07
ATC
prednisone; oral
2.9
6.5
33
127
A02BC02
ATC
pantoprazole; systemic
2.2
6.3
142
1031
R11
ICD-10 Finland
Nausea and vomiting
3.3
6.3
25
83
00690
ICD-8 Finland
Amoebiasis, Sine abscessu hepatis
+∞
6.3
6
*
R51.80
ICD-10 Finland
Headache
2.5
6.1
44
202
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
45
55
10.14
35.63
3.6
1.7
—
—
—
0
0
45
166
3.18
9.70
2.1
3.2
4.41
7.96
umol/l
1.67
37
139
128
810
2.49
9.31
5.8
5.7
10.10
11.34
umol/l
1.37
120
761
106
631
2.37
8.65
5.7
4.3
36.44
36.26
g/l
0.13
97
597
54
253
2.53
7.31
2.9
2.5
1.06
0.77
e6/l
0.21
25
145
111
708
2.20
7.31
7.6
6.4
1.21
1.22
mmol/l
0.14
106
653
78
438
2.24
6.97
3.9
2.8
0.25
0.25
e6/l
0.02
54
323
104
659
2.15
6.82
2.6
2.2
75.60
77.34
nmol/l
0.23
98
583
49
236
2.40
6.18
3.0
2.6
1.50
2.51
e6/l
0.41
21
128
82
497
2.07
5.84
3.0
2.4
53.70
68.02
u/l
0.85
73
457
134
970
2.05
5.80
10.7
9.5
3.98
4.02
e9/l
0.07
115
843
89
559
2.03
5.73
4.2
2.9
—
—
—
0
0
114
783
2.00
5.68
8.4
6.6
1.21
1.22
mmol/l
0.93
100
661
83
520
1.99
5.29
3.5
3.1
30.44
28.43
u/l
0.43
78
497
67
389
2.06
5.28
4.1
2.8
9475.96
5011.17
umol/l
0.20
55
333
23
81
3.07
5.28
1.9
1.4
—
—
—
0
0
33
143
2.55
5.17
3.9
5.4
6.13
5.92
kpa
0.55
33
138
76
465
1.99
5.16
1.9
2.1
133.03
314.49
u/l
0.71
68
437
16
45
3.77
5.15
1.4
1.1
—
—
—
0
0
28
112
2.73
5.13
1.0
1.0
—
—
—
0
0
16
46
3.68
5.00
1.4
1.1
—
—
—
0
0
48
252
2.17
4.88
1.9
1.6
1044.90
1299.02
nmol/l
1.22
39
188
23
88
2.81
4.57
1.5
1.3
—
—
—
0
0
9
12
7.78
4.40
3.1
1.1
—
—
—
0
0
111
805
1.80
4.25
6.8
4.6
0.00
0.01
estimate
0.50
18
157
9
13
7.18
4.21
3.1
1.2
—
—
—
0
0
111
810
1.79
4.12
5.0
3.4
0.00
0.00
estimate
-0.00
18
153
109
795
1.77
4.02
5.0
3.4
0.00
0.00
estimate
-0.00
19
167
160
1312
1.92
3.96
4.1
3.8
14.88
14.69
pmol/l
0.38
146
1185
66
418
1.84
3.88
1.5
1.3
0.64
1.26
u/ml
1.43
12
110
14
44
3.34
3.85
2.0
1.4
230.63
339.20
ug/g
—
8
22
87
606
1.74
3.69
2.2
1.8
98.06
97.79
pmol/l
0.02
43
301
48
281
1.92
3.57
2.9
2.8
2.43
2.45
mmol/l
0.50
41
247
80
550
1.73
3.52
3.5
2.9
2.34
2.36
mmol/l
0.36
68
487
153
1258
1.80
3.49
9.2
6.3
79.46
82.73
u/l
0.43
146
1168
34
178
2.09
3.44
11.3
8.2
103.79
103.80
mmol/l
0.00
34
178
5
5
10.20
2.99
1.2
1.0
—
—
—
0
0
5
5
10.20
2.99
2.6
1.2
24.60
30.20
umol/l
—
5
5
189
1701
2.11
2.76
19.3
11.6
23.44
21.90
mg/l
0.24
159
1275
45
281
1.77
2.70
2.9
2.9
113.35
132.96
ng/l
0.10
34
210
5
7
7.28
2.56
1.2
1.6
—
—
—
0
0
26
140
1.98
2.45
2.8
2.4
0.22
0.22
g/l
0.21
21
131
5
8
6.37
2.38
1.2
1.0
92.20
97.50
%
—
5
8
91
699
1.53
2.36
12.3
14.5
1.14
1.27
inr
0.75
24
215
61
428
1.60
2.35
4.1
3.7
16.77
8.27
mg/mmol
0.62
40
267
54
370
1.62
2.29
2.4
2.0
2.52
2.90
mg/l
0.87
42
310
9
29
3.20
2.25
1.3
1.6
—
—
—
0
0
47
312
1.65
2.25
1.6
1.7
431.92
467.09
pmol/l
0.31
40
261
174
1566
1.65
1.99
5.4
4.5
1.75
2.65
mu/l
0.60
164
1419
8
28
2.93
1.88
1.0
1.3
—
—
—
0
0
113
937
1.45
1.88
6.9
5.0
6.91
6.57
mmol/l
0.64
108
856
48
340
1.53
1.75
1.6
1.9
0.86
1.14
mg/l
0.44
32
262
59
437
1.49
1.74
5.8
3.7
0.00
0.01
estimate
0.50
18
155
19
104
1.91
1.74
7.4
8.7
24.71
25.09
mmol/l
0.11
19
104
7
24
2.98
1.74
1.0
1.5
—
—
—
0
0
7
24
2.98
1.74
1.0
1.5
—
—
—
0
0
24
142
1.78
1.73
1.7
1.6
—
—
—
0
0
50
360
1.51
1.69
2.5
2.2
—
—
—
0
0
135
1171
1.43
1.67
3.3
3.3
—
—
—
0
0
11
49
2.31
1.66
1.1
1.1
—
—
—
0
0
25
152
1.73
1.65
3.4
3.2
—
—
—
0
0
5
14
3.63
1.62
1.2
1.0
—
—
—
0
0
20
116
1.80
1.55
3.3
3.1
65.67
66.65
ml/min/173m2
—
9
49
10
45
2.28
1.49
1.4
1.4
—
—
—
0
0
78
627
1.39
1.46
5.5
3.6
—
—
—
0
0
172
1578
1.50
1.44
3.7
3.8
1.27
1.27
mmol/l
0.01
161
1441
10
46
2.23
1.42
5.1
9.8
1.71
1.40
mg/l
—
10
40
49
367
1.44
1.35
1.6
1.7
—
—
—
0
0
9
42
2.19
1.35
1.1
1.4
—
—
—
0
0
14
76
1.90
1.33
2.9
5.1
0.77
0.66
%
0.33
14
76
13
69
1.94
1.31
1.4
1.3
—
—
—
0
0
6
24
2.54
1.31
2.5
1.3
—
—
—
0
0
10
48
2.14
1.30
1.2
1.3
—
—
—
0
0
11
56
2.02
1.24
1.2
2.6
—
—
—
0
0
14
78
1.85
1.24
2.9
5.0
0.89
1.41
%
1.81
14
78
8
37
2.21
1.23
1.5
1.4
—
—
—
0
0
5
19
2.67
1.22
1.8
1.2
—
—
—
0
0
40
295
1.44
1.20
1.4
1.3
30.50
25.24
iu/ml
—
9
104
22
142
1.61
1.20
1.8
1.5
—
—
—
0
0
19
118
1.67
1.19
1.4
1.7
—
—
—
0
0
6
26
2.34
1.19
1.5
1.2
—
—
—
0
0
53
416
1.37
1.12
1.9
1.6
1.51
1.38
mmol/l
0.48
48
348
5
21
2.41
1.09
1.4
1.7
—
—
—
0
0
87
740
1.30
1.06
2.9
2.5
—
—
—
0
0
7
34
2.09
1.04
3.9
3.3
59.69
257.49
mg/l
—
7
28
7
34
2.09
1.04
1.6
2.2
—
—
—
0
0
7
34
2.09
1.04
3.9
3.4
45.74
25.52
mg/l
—
7
28
49
385
1.36
1.03
1.7
1.4
22.19
22.01
nmol/l
0.03
42
322
128
1148
1.29
1.03
3.2
2.9
55.12
46.38
u/l
0.45
122
1078
18
116
1.60
1.00
1.6
1.2
—
57.30
—
0
5
22
151
1.51
0.95
12.8
11.6
-0.71
1.62
mmol/l
0.73
17
129
29
212
1.43
0.93
1.8
1.7
—
—
—
0
0
70
591
1.28
0.88
3.6
3.1
32.02
42.93
ng/l
0.39
53
399
6
30
2.03
0.87
1.5
1.8
—
—
—
0
0
6
30
2.03
0.87
1.0
1.2
—
—
—
0
0
12
72
1.71
0.87
4.6
3.0
46.98
49.96
%
0.18
12
72
49
398
1.30
0.82
3.3
3.2
1214.61
1137.03
ng/l
0.06
42
330
6
32
1.90
0.82
1.5
1.8
—
—
—
0
0
14
90
1.60
0.80
1.5
1.2
230.25
169.91
u/ml
0.17
14
83
15
99
1.55
0.78
1.3
1.6
—
—
—
0
0
15
99
1.55
0.78
17.9
9.8
1.21
1.44
%
0.57
15
99
15
99
1.55
0.78
17.9
10.2
0.66
0.71
%
0.24
15
99
5
24
2.11
0.75
1.6
1.8
—
—
—
0
0
166
1566
1.29
0.75
17.2
11.0
84.50
83.98
ml/min/173m2
0.10
138
1271
14
92
1.56
0.74
1.6
1.3
—
—
—
0
0
161
1514
1.27
0.74
6.0
5.2
39.78
39.19
mmol/mol
0.25
151
1395
12
76
1.61
0.73
1.3
2.0
5.70
3.28
mg/l
—
7
58
5
25
2.02
0.73
1.4
1.1
—
—
—
0
0
188
1806
1.39
0.72
13.7
9.2
27.83
25.72
u/l
0.30
183
1737
7
40
1.78
0.72
3.0
3.2
24.03
25.44
mmol/l
—
7
40
36
287
1.31
0.70
1.5
1.3
3.49
12.17
u/ml
1.20
12
110
12
175
0.67
0.63
1.4
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
3.6
—
75.15
—
0
20
171
1633
1.25
0.59
4.4
4.1
1.46
1.47
mmol/l
0.12
161
1497
172
1644
1.26
0.59
4.4
4.1
4.62
4.67
mmol/l
0.22
161
1520
195
1904
1.34
0.45
28.2
17.9
39.72
40.48
%
1.03
190
1806
173
1669
1.21
0.44
5.0
4.6
2.74
2.77
mmol/l
0.18
163
1532
26
214
1.25
0.42
1.8
1.7
1.55
1.42
%
0.26
21
191
0
17
0.00
0.41
0.0
1.3
—
—
—
0
0
8
61
1.32
0.40
1.8
1.8
29.88
40.08
nmol/l
—
8
61
195
1910
1.29
0.37
27.5
17.7
133.48
136.30
g/l
1.91
195
1880
6
42
1.44
0.36
2.2
4.5
148.50
168.57
%
—
6
42
28
240
1.19
0.32
2.0
2.3
—
—
—
0
0
30
260
1.18
0.31
1.5
1.5
—
—
—
0
0
26
225
1.18
0.27
1.9
2.1
—
—
—
0
0
9
74
1.23
0.25
2.6
1.5
417.00
325.71
mu/l
—
9
69
0
10
0.00
0.21
0.0
2.2
—
48.06
—
0
10
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
4.0
—
—
—
0
0
30
269
1.13
0.21
3.5
2.8
0.65
0.69
ug/l
0.15
22
167
165
1618
1.09
0.17
4.4
4.2
6.03
5.83
mmol/l
0.83
147
1475
9
79
1.15
0.15
1.9
2.8
0.31
0.13
e6/l
—
9
73
21
188
1.13
0.15
4.4
4.3
27.14
31.93
%
1.10
14
122
15
133
1.14
0.12
1.7
2.2
3.39
5.96
ug/l
1.08
15
118
6
54
1.11
0.09
2.2
1.5
—
—
—
0
0
6
55
1.09
0.09
1.0
1.1
—
14.62
—
0
13
15
136
1.11
0.09
4.8
3.4
1.26
1.23
mmol/l
1.61
15
122
6
56
1.07
0.08
1.3
1.9
—
—
—
0
0
20
186
1.08
0.07
13.6
6.0
—
—
—
0
0
47
454
1.05
0.06
5.6
4.4
1.63
1.83
ug/l
0.24
42
393
38
365
1.05
0.06
4.0
4.0
25.09
22.81
%
0.26
16
162
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
56.75
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
11.2
5.2
3.90
3.98
mmol/l
—
5
53
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
108.18
—
0
6
0
5
0.00
-0.00
0.0
4.4
—
154.12
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
39.12
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_AMOEBIASIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_AMOEBIASIS | 1.655 [1.34, 2.04] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.218 |
During the follow-up period (1.1.1998 — 31.12.2019), 241 out of 965 females with AB1_AMOEBIASIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_AMOEBIASIS | 1.981 [1.42, 2.76] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 202 out of 870 males with AB1_AMOEBIASIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_AMOEBIASIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.174% | 0.37% |
| 5 | 0.862% | 2.264% |
| 10 | 2.187% | 5.55% |
| 15 | 4.515% | 10.558% |
| 20 | 7.752% | 17.621% |
Relationships between endpoints
↥Index endpoint: AB1_AMOEBIASIS – Amoebiasis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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