No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
297 |
4. Check minimum number of eventsNone |
297 |
5. Include endpointsNone |
297 |
6. Filter based on genotype QC (FinnGen only) |
290 |
Control definitions (FinnGen only)
- Control exclude
- AB1_OTHER_BACTERIAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Meningococcal infection
based on the number of shared cases.
Similar with more cases:
- Other bacterial diseases
- Other bacterial diseases
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3391 | 1544 | 1828 |
| Only index persons | 2683 | 1246 | 1437 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.04 | 0.05 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 17.73 | 17.89 | 17.27 |
| Only index persons | 16.06 | 16.30 | 15.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 290 | 166 | 124 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 18.22 | 17.79 | 18.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 297
- Matched controls
- 2970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
03600
ICD-8 Finland
Meningococcal infection, Meningococcal meningitis
+∞
122.6
109
*
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
44.9
42
*
0360A
ICD-9 Finland
Meningococcal infection, Meningococcal meningitis
+∞
32.9
31
*
A39.2
ICD-10 Finland
Acute meningococcaemia
+∞
25.4
24
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
118.4
20.9
22
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
26.0
17.6
24
10
A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
15.8
15
*
03697
ICD-8 Finland
Meningococcal infection, Suspecta
+∞
14.7
14
*
A39.9
ICD-10 Finland
Meningococcal infection, unspecified
+∞
14.7
14
*
03610
ICD-8 Finland
Meningococcal infection, Meningococcaemia acuta sive non definita
+∞
13.6
13
*
A41.9
ICD-10 Finland
Sepsis, unspecified
135.5
12.5
13
*
Z2446
NOMESCO Finland
Social worker
4.0
10.9
32
86
A46
ICD-10 Finland
Erysipelas
4.5
9.8
25
60
A41.8
ICD-10 Finland
Other specified sepsis
+∞
8.4
8
*
0362A
ICD-9 Finland
Meningococcal infection, Meningococcaemia
+∞
8.4
8
*
G03.9
ICD-10 Finland
Meningitis, unspecified
46.2
7.8
9
*
WX730
NOMESCO Finland
Conventional respirator
19.0
7.7
11
6
OAA81, ,
SPAT
4.3
6.9
18
44
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.6
6.8
23
68
A39.8
ICD-10 Finland
Other meningococcal infections
+∞
6.3
6
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
6.2
39
166
N06AB04
ATC
citalopram; systemic
2.1
6.0
67
364
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
247
2.02
4.23
1.6
1.6
—
—
—
0
0
22
86
2.68
4.16
7.1
8.5
26.07
24.77
mmol/l
0.72
22
86
21
82
2.68
3.98
1.8
1.4
—
—
—
0
0
48
273
1.90
3.74
3.5
3.1
0.81
0.82
mmol/l
0.32
42
258
137
1058
1.55
3.37
6.6
5.2
28.14
29.25
%
0.46
126
1005
6
7
8.72
3.27
1.3
1.1
—
—
—
0
0
6
7
8.72
3.27
1.2
1.3
—
—
—
0
0
76
525
1.60
2.98
2.3
2.2
315.31
5307.34
umol/l
1.98
65
464
8
18
4.54
2.81
1.6
1.8
—
—
—
0
0
108
824
1.49
2.67
12.3
10.7
1.16
1.18
inr
0.12
36
246
5
7
7.24
2.56
1.2
1.1
—
—
—
0
0
31
177
1.84
2.41
1.6
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
8
6.33
2.38
1.4
1.3
—
—
—
0
0
12
47
2.62
2.30
1.0
1.1
—
—
—
0
0
31
182
1.79
2.22
1.6
1.6
—
—
—
0
0
20
101
2.05
2.21
8.7
12.6
90.58
93.98
%
0.75
20
101
37
235
1.66
2.02
4.6
4.1
28.15
30.62
%
1.15
27
164
12
51
2.41
1.97
2.1
2.9
4.57
3.37
g/l
1.66
12
51
6
16
3.80
1.94
1.2
1.3
—
—
—
0
0
106
848
1.39
1.92
3.9
3.5
35.85
37.04
g/l
1.04
91
801
108
870
1.38
1.87
7.4
4.8
1.21
1.22
mmol/l
0.53
93
789
13
59
2.26
1.87
4.2
2.5
—
—
—
0
0
97
774
1.38
1.77
2.0
1.8
96.54
96.10
pmol/l
0.03
46
400
29
182
1.66
1.68
2.9
2.7
—
—
—
0
0
139
1182
1.33
1.65
4.6
4.0
6.45
6.48
mmol/l
0.06
127
1083
85
672
1.37
1.63
3.5
2.8
2.36
2.36
mmol/l
0.09
71
609
61
460
1.41
1.54
2.0
1.8
—
—
—
0
0
33
220
1.56
1.52
4.8
5.9
—
—
—
0
0
41
562
0.69
1.44
1.4
1.3
0.64
1.72
u/ml
0.83
14
157
18
104
1.78
1.40
9.5
12.2
0.61
0.72
%
0.65
18
104
18
105
1.76
1.36
9.6
11.9
1.81
1.57
%
0.25
18
105
57
439
1.37
1.28
2.2
1.9
2.78
2.89
mg/l
0.12
47
369
34
238
1.48
1.27
2.4
2.1
6.69
6.15
umol/l
0.09
29
201
8
36
2.26
1.25
1.4
2.4
—
—
—
0
0
118
1012
1.28
1.23
2.7
2.5
109.84
90.35
ug/l
0.50
109
944
144
1268
1.26
1.20
9.2
7.8
4.11
3.91
e9/l
0.54
123
1107
8
38
2.14
1.19
1.6
1.2
—
—
—
0
0
8
38
2.14
1.19
1.6
1.2
—
—
—
0
0
188
1710
1.27
1.19
4.2
3.5
13.01
9.57
mm/h
2.27
174
1584
58
454
1.34
1.18
4.1
3.3
1499.31
906.52
ng/l
0.51
49
379
10
50
2.03
1.18
1.0
1.2
—
—
—
0
0
5
20
2.52
1.15
1.4
1.4
—
—
—
0
0
16
96
1.70
1.12
1.5
1.4
—
—
—
0
0
7
31
2.29
1.11
1.1
1.2
—
—
—
0
0
7
31
2.29
1.11
2.0
1.5
—
—
—
0
0
111
958
1.25
1.08
8.6
5.0
1.21
1.22
mmol/l
0.25
87
806
39
291
1.39
1.07
1.7
1.6
1188.33
1175.09
nmol/l
0.03
29
224
5
22
2.29
1.04
1.0
1.4
—
—
—
0
0
7
34
2.08
1.03
1.0
1.1
—
—
—
0
0
59
474
1.31
1.01
1.8
1.7
1.12
1.02
mg/l
0.13
47
355
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
9
51
1.79
0.95
1.3
1.5
—
—
—
0
0
29
210
1.42
0.95
9.1
3.9
1.10
1.04
mmol/l
0.54
23
192
7
37
1.91
0.94
1.7
3.5
59.00
55.27
%
—
7
37
5
104
0.47
0.90
14.0
6.0
28.02
24.54
mmol/l
—
5
98
10
56
1.81
0.89
1.5
1.5
—
—
—
0
0
6
115
0.51
0.84
1.5
2.2
—
—
—
0
0
17
113
1.54
0.84
1.2
1.3
—
—
—
0
0
8
47
1.72
0.81
1.1
1.1
—
—
—
0
0
30
388
0.75
0.76
1.5
1.6
484.92
441.76
pmol/l
0.21
24
335
43
350
1.27
0.69
3.0
2.4
2.43
2.43
mmol/l
0.04
36
314
15
213
0.69
0.67
1.5
1.9
—
—
—
0
0
189
1780
1.17
0.62
3.8
3.8
14.64
14.60
pmol/l
0.09
175
1653
45
374
1.24
0.61
3.1
3.6
50.34
220.77
ng/l
1.89
32
256
224
2148
1.17
0.55
4.4
4.4
1.60
2.40
mu/l
0.83
205
2005
34
412
0.80
0.55
1.4
1.4
—
—
—
0
0
51
436
1.20
0.54
1.4
1.3
40.75
29.52
iu/ml
0.28
15
148
18
134
1.37
0.54
1.2
1.2
71.82
210.68
u/ml
1.89
18
121
6
40
1.51
0.52
1.3
1.6
—
—
—
0
0
78
699
1.16
0.49
3.2
2.6
—
—
—
0
0
71
632
1.16
0.48
2.3
2.1
51.74
66.57
u/l
1.20
61
585
244
2364
1.18
0.48
15.9
10.9
3.94
3.95
mmol/l
0.25
239
2296
5
81
0.61
0.46
4.2
2.0
3.26
1.39
%
—
5
81
12
86
1.41
0.45
1.3
1.2
—
—
—
0
0
9
131
0.68
0.44
1.0
1.0
—
—
—
0
0
26
212
1.25
0.44
8.5
6.7
104.04
103.93
mmol/l
0.03
26
212
13
173
0.74
0.43
1.5
1.9
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
20
159
1.28
0.41
8.9
8.0
129.55
125.39
g/l
0.40
20
153
0
15
0.00
0.41
0.0
1.1
—
180.04
—
0
15
242
2352
1.16
0.41
15.9
10.8
139.50
139.78
mmol/l
1.13
237
2291
5
35
1.44
0.39
2.4
2.3
—
—
—
0
0
79
863
0.88
0.39
3.1
3.1
—
—
—
0
0
182
1742
1.12
0.38
3.2
2.7
46.94
40.27
u/l
0.76
171
1672
102
1096
0.89
0.38
4.1
4.3
0.00
0.00
estimate
-0.00
20
217
103
1106
0.89
0.38
3.3
3.1
0.00
0.00
estimate
-0.00
18
203
229
2223
1.13
0.36
12.1
9.4
89.42
87.24
ml/min/173m2
0.78
186
1800
104
972
1.11
0.34
2.4
2.2
—
—
—
0
0
232
2258
1.13
0.33
4.0
4.0
5.89
5.79
mmol/l
0.55
214
2101
176
1694
1.10
0.30
7.6
6.0
78.38
73.97
u/l
0.68
169
1594
57
624
0.89
0.29
1.5
1.6
1.53
1.44
mmol/l
0.22
49
540
94
881
1.10
0.29
2.5
2.2
74.75
75.95
nmol/l
0.16
84
791
257
2525
1.13
0.27
14.8
11.2
74.30
73.96
umol/l
0.05
257
2525
207
2122
0.92
0.24
17.3
12.2
14.39
14.54
%
0.16
201
2096
43
471
0.90
0.23
3.0
3.6
25.39
20.66
%
0.47
14
175
5
40
1.25
0.22
1.2
1.2
—
—
—
0
0
225
2295
0.92
0.22
3.6
3.6
1.37
1.31
mmol/l
0.48
211
2153
0
10
0.00
0.21
0.0
1.0
—
27.14
—
0
10
0
12
0.00
0.21
0.0
1.1
—
1678.08
—
0
12
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
9.8
—
32.57
—
0
7
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
28
312
0.89
0.20
2.0
1.7
—
—
—
0
0
105
1096
0.94
0.19
3.3
3.1
0.00
0.00
estimate
-0.00
19
231
11
90
1.23
0.19
1.5
1.4
—
—
—
0
0
6
53
1.13
0.19
2.0
1.5
—
—
—
0
0
5
66
0.75
0.17
1.6
1.6
—
—
—
0
0
8
73
1.10
0.16
1.0
1.1
—
—
—
0
0
8
73
1.10
0.16
1.5
1.5
—
—
—
0
0
6
80
0.74
0.15
1.2
1.1
—
—
—
0
0
9
82
1.10
0.15
2.0
1.6
—
—
—
0
0
16
141
1.14
0.14
1.9
2.3
2.76
8.82
ug/l
—
10
127
34
366
0.92
0.14
2.6
2.6
0.65
0.66
ug/l
0.03
19
201
8
97
0.82
0.14
1.8
2.4
0.19
0.15
e6/l
—
8
92
75
721
1.05
0.12
3.5
3.1
25.88
33.69
ng/l
0.50
49
419
272
2701
1.08
0.10
20.2
14.8
257.52
254.64
e9/l
0.27
264
2652
33
350
0.94
0.10
2.0
2.1
—
—
—
0
0
58
558
1.05
0.09
1.7
1.5
—
—
—
0
0
58
559
1.05
0.08
4.2
3.5
20.36
5.99
mg/mmol
0.48
40
360
7
66
1.06
0.08
3.4
2.7
9.14
431.39
u/ml
—
7
61
37
388
0.95
0.08
2.1
2.2
—
—
—
0
0
6
74
0.81
0.07
1.8
1.5
—
—
—
0
0
6
74
0.81
0.07
1.8
1.5
—
—
—
0
0
6
74
0.81
0.07
1.7
1.5
—
—
—
0
0
7
80
0.87
0.07
1.1
1.1
—
—
—
0
0
272
2705
1.07
0.07
20.1
14.7
4.50
4.60
e12/l
2.51
264
2652
40
416
0.96
0.06
1.6
1.3
6.65
8.42
u/ml
0.13
15
170
244
2423
1.04
0.06
4.2
4.3
2.88
2.88
mmol/l
0.04
230
2279
240
2384
1.03
0.05
15.4
9.7
24.49
20.01
mg/l
1.35
202
1787
14
151
0.92
0.05
1.1
1.3
—
—
—
0
0
58
566
1.03
0.04
3.6
3.5
0.00
0.00
estimate
0.50
18
212
237
2382
0.98
0.03
3.9
3.9
1.46
1.47
mmol/l
0.06
223
2248
32
330
0.97
0.03
3.3
2.2
1.19
0.96
e6/l
0.27
22
174
212
2131
0.98
0.02
5.0
4.8
39.11
38.88
mmol/mol
0.13
200
2027
14
132
1.06
0.02
1.6
1.5
—
—
—
0
0
179
1780
1.01
0.02
3.4
3.4
—
—
—
0
0
271
2702
1.03
0.02
20.2
14.9
40.63
41.04
%
0.66
263
2571
45
442
1.02
0.01
1.5
1.4
22.19
22.19
nmol/l
0.00
35
378
57
562
1.02
0.01
3.6
2.4
0.22
0.41
e6/l
0.59
47
413
239
2392
1.00
0.00
3.9
4.0
4.83
4.79
mmol/l
0.27
224
2265
31
311
1.00
0.00
3.4
2.4
2.24
1.81
e6/l
0.15
21
155
255
2553
0.99
0.00
9.9
8.3
26.84
27.81
u/l
0.41
245
2488
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
9
89
1.01
0.00
1.2
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
-0.00
1.1
1.1
—
2.70
—
0
10
0
9
0.00
-0.00
0.0
1.4
—
9.02
—
0
9
6
69
0.87
-0.00
1.0
1.2
—
—
—
0
0
6
62
0.97
-0.00
1.0
1.4
—
—
—
0
0
7
78
0.89
-0.00
1.6
1.5
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.3
—
10.81
—
0
10
0
9
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_MENINGOCOCCAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MENINGOCOCCAL | 2.491 [1.73, 3.59] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.475 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 463 females with AB1_MENINGOCOCCAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MENINGOCOCCAL | 2.574 [1.72, 3.86] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 513 males with AB1_MENINGOCOCCAL died.
Mortality risk
Mortality risk for people of age
years, who have AB1_MENINGOCOCCAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.429% |
| 5 | 1.429% | 2.889% |
| 10 | 3.829% | 7.419% |
| 15 | 7.655% | 14.077% |
| 20 | 13.33% | 23.471% |
Relationships between endpoints
↥Index endpoint: AB1_MENINGOCOCCAL – Meningococcal infection
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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