No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
292 |
4. Check minimum number of eventsNone |
292 |
5. Include endpointsNone |
292 |
6. Filter based on genotype QC (FinnGen only) |
292 |
Control definitions (FinnGen only)
- Control exclude
- AB1_OTHER_BACTERIAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Meningococcal infection
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3391 | 1544 | 1828 |
| Only index persons | 2683 | 1246 | 1437 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.04 | 0.05 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 17.73 | 17.89 | 17.27 |
| Only index persons | 16.06 | 16.30 | 15.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 292 | 168 | 124 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | 18.05 | 17.62 | 18.62 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 267
- Matched controls
- 2668
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
03600
ICD-8 Finland
Meningococcal infection, Meningococcal meningitis
+∞
112.7
100
*
G01*A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
41.8
39
*
0360A
ICD-9 Finland
Meningococcal infection, Meningococcal meningitis
+∞
30.8
29
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
+∞
23.3
22
*
A39.2
ICD-10 Finland
Acute meningococcaemia
+∞
22.2
21
*
A39.0
ICD-10 Finland
Meningococcal meningitis
+∞
15.8
15
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
38.4
14.6
18
5
03697
ICD-8 Finland
Meningococcal infection, Suspecta
+∞
13.7
13
*
03610
ICD-8 Finland
Meningococcal infection, Meningococcaemia acuta sive non definita
+∞
12.6
12
*
A41.9
ICD-10 Finland
Sepsis, unspecified
125.2
11.5
12
*
A39.9
ICD-10 Finland
Meningococcal infection, unspecified
+∞
9.4
9
*
0362A
ICD-9 Finland
Meningococcal infection, Meningococcaemia
+∞
8.4
8
*
G03.9
ICD-10 Finland
Meningitis, unspecified
71.5
6.5
7
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
88
2.49
3.48
6.1
8.6
26.2
24.8
mmol/l
0.73
21
88
46
271
1.83
3.22
2.9
3.1
0.8
0.8
mmol/l
0.21
40
254
42
250
1.79
2.85
1.5
1.5
—
—
—
0
0
74
520
1.57
2.69
2.4
2.2
316.8
5427.7
umol/l
1.98
63
453
5
7
7.24
2.56
1.2
1.3
—
—
—
0
0
5
7
7.24
2.56
1.4
1.1
—
—
—
0
0
5
7
7.24
2.56
1.2
1.1
—
—
—
0
0
7
17
4.19
2.37
1.7
1.6
—
—
—
0
0
18
85
2.19
2.34
1.5
1.4
—
—
—
0
0
12
47
2.62
2.30
2.1
2.9
4.6
3.4
g/l
1.67
12
47
19
96
2.05
2.10
7.6
13.1
90.5
94.3
%
0.80
19
96
37
236
1.65
1.99
4.6
4.1
28.2
30.6
%
1.09
27
161
6
16
3.80
1.94
1.2
1.3
—
—
—
0
0
13
58
2.30
1.94
4.2
2.5
—
—
—
0
0
13
58
2.30
1.94
4.2
2.5
4.1
3.6
g/l
—
8
45
29
179
1.69
1.78
2.9
2.7
—
—
—
0
0
105
857
1.35
1.65
6.9
4.9
1.2
1.2
mmol/l
0.32
90
777
103
839
1.35
1.64
3.9
3.6
36.0
37.0
g/l
0.92
88
790
84
668
1.36
1.55
3.5
2.8
2.4
2.4
mmol/l
0.20
70
598
40
553
0.68
1.47
1.4
1.3
0.6
1.8
u/ml
0.83
14
152
32
214
1.56
1.46
4.5
6.0
—
—
—
0
0
34
232
1.53
1.42
2.4
2.1
6.7
6.1
umol/l
0.10
29
196
59
449
1.39
1.42
2.0
1.9
—
—
—
0
0
93
765
1.32
1.35
2.0
1.8
96.9
95.8
pmol/l
0.06
43
397
10
47
2.17
1.35
1.0
1.1
—
—
—
0
0
27
178
1.57
1.32
1.4
1.5
—
—
—
0
0
17
99
1.76
1.30
8.4
12.7
0.6
0.7
%
0.62
17
99
10
48
2.12
1.29
1.0
1.2
—
—
—
0
0
135
1175
1.28
1.27
4.3
4.0
6.5
6.5
mmol/l
0.08
123
1076
17
100
1.74
1.26
8.4
12.3
1.9
1.6
%
0.37
17
100
8
37
2.19
1.22
1.6
1.2
—
—
—
0
0
8
37
2.19
1.22
1.6
1.2
—
—
—
0
0
5
19
2.66
1.22
1.4
1.4
—
—
—
0
0
27
182
1.53
1.21
1.4
1.5
—
—
—
0
0
7
31
2.29
1.11
1.1
1.2
—
—
—
0
0
57
454
1.32
1.04
3.7
3.3
1477.1
972.3
ng/l
0.40
48
381
5
22
2.29
1.04
1.0
1.4
—
—
—
0
0
115
1001
1.25
1.03
2.8
2.6
111.8
90.9
ug/l
0.53
106
934
7
34
2.08
1.03
1.0
1.1
—
—
—
0
0
7
34
2.08
1.03
1.4
2.3
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
38
287
1.37
0.98
1.6
1.6
1164.4
1148.3
nmol/l
0.04
28
220
140
1253
1.23
0.95
8.1
7.8
4.1
3.9
e9/l
0.39
119
1096
5
102
0.48
0.91
14.0
6.2
28.0
24.4
mmol/l
—
5
94
58
472
1.29
0.91
1.8
1.7
1.1
0.9
mg/l
0.22
46
353
183
1689
1.22
0.90
4.2
3.5
13.0
9.6
mm/h
2.16
169
1567
54
438
1.29
0.87
2.2
1.9
2.8
2.9
mg/l
0.08
44
370
8
45
1.80
0.85
1.1
1.1
—
—
—
0
0
6
31
1.95
0.85
2.0
1.5
—
—
—
0
0
107
944
1.21
0.82
8.2
5.1
1.2
1.2
mmol/l
0.27
82
795
29
381
0.73
0.82
1.5
1.7
484.9
439.1
pmol/l
0.23
24
331
10
59
1.72
0.76
1.5
1.4
—
—
—
0
0
9
54
1.69
0.75
1.3
1.4
—
—
—
0
0
6
110
0.54
0.73
1.5
2.1
—
—
—
0
0
28
215
1.33
0.68
9.3
4.2
1.1
1.1
mmol/l
0.52
22
196
42
346
1.25
0.62
3.1
2.4
2.4
2.4
mmol/l
0.10
35
310
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
15
208
0.71
0.60
1.6
1.9
—
—
—
0
0
186
1754
1.17
0.60
3.8
3.8
14.6
14.6
pmol/l
0.04
172
1627
98
1084
0.86
0.59
4.1
4.3
0.0
0.0
estimate
0.00
20
214
99
1094
0.86
0.59
3.3
3.2
0.0
0.0
estimate
0.00
18
200
71
626
1.18
0.54
2.3
2.1
51.7
57.8
u/l
1.42
61
576
34
411
0.80
0.54
1.4
1.4
—
—
—
0
0
220
2113
1.17
0.51
4.4
4.5
1.6
2.4
mu/l
0.80
201
1973
77
856
0.86
0.49
3.1
3.1
—
—
—
0
0
50
433
1.19
0.47
1.4
1.3
40.7
27.3
iu/ml
0.36
15
146
13
94
1.40
0.46
1.5
1.4
—
—
—
0
0
43
369
1.19
0.45
3.0
3.6
51.7
225.4
ng/l
1.86
30
250
9
130
0.68
0.44
1.0
1.0
—
—
—
0
0
15
113
1.35
0.43
1.2
1.3
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
180
1718
1.12
0.41
3.2
2.7
47.2
40.3
u/l
0.79
169
1649
17
132
1.31
0.41
1.2
1.2
68.8
213.5
u/ml
1.96
17
119
55
618
0.86
0.41
1.5
1.6
1.5
1.4
mmol/l
0.24
47
535
13
168
0.76
0.36
1.5
1.9
—
—
—
0
0
6
41
1.47
0.36
1.5
1.6
—
—
—
0
0
239
2331
1.14
0.34
15.3
11.0
3.9
4.0
mmol/l
0.23
234
2263
101
1080
0.90
0.34
3.3
3.1
0.0
0.0
estimate
0.00
19
213
25
210
1.21
0.34
7.6
6.7
103.9
103.8
mmol/l
0.02
25
202
19
155
1.24
0.33
7.8
8.1
131.1
124.9
g/l
0.67
19
146
11
83
1.34
0.32
1.3
1.2
—
—
—
0
0
102
955
1.10
0.32
3.6
3.5
—
—
—
0
0
225
2190
1.12
0.32
11.7
9.5
89.3
87.1
ml/min/173m2
0.78
182
1776
74
685
1.11
0.29
3.1
2.6
—
—
—
0
0
237
2319
1.12
0.28
15.3
10.9
139.5
139.8
mmol/l
1.27
232
2258
29
329
0.87
0.26
3.0
2.2
1.2
1.0
e6/l
0.22
20
176
42
464
0.89
0.26
3.0
3.6
25.4
21.1
%
0.42
14
174
198
2034
0.92
0.25
16.6
12.4
13.7
13.5
%
0.52
192
2003
227
2223
1.09
0.23
4.0
3.9
5.9
5.8
mmol/l
0.42
209
2068
5
40
1.25
0.22
1.2
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
27.1
—
0
10
0
12
0.00
0.21
0.0
1.1
—
1678.1
—
0
12
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
9.8
—
32.6
—
0
7
221
2253
0.92
0.21
3.6
3.6
1.4
1.3
mmol/l
0.46
207
2113
11
90
1.23
0.19
1.5
1.4
—
—
—
0
0
172
1674
1.07
0.19
7.4
6.1
77.9
74.1
u/l
0.55
164
1571
6
53
1.13
0.19
2.0
1.5
—
—
—
0
0
5
67
0.74
0.17
1.6
1.6
—
—
—
0
0
28
308
0.90
0.17
3.0
2.4
2.4
1.8
e6/l
0.21
19
155
252
2489
1.09
0.16
14.3
11.4
74.3
74.3
umol/l
0.00
252
2489
8
71
1.13
0.16
1.5
1.5
—
—
—
0
0
28
307
0.90
0.16
2.0
1.7
—
—
—
0
0
8
72
1.11
0.16
1.0
1.1
—
—
—
0
0
6
78
0.76
0.15
1.2
1.1
—
—
—
0
0
9
81
1.11
0.15
2.0
1.6
—
—
—
0
0
58
550
1.07
0.14
1.7
1.5
—
—
—
0
0
8
99
0.80
0.14
1.8
2.3
0.2
0.2
e6/l
—
8
94
16
142
1.13
0.13
1.9
2.3
2.8
8.9
ug/l
—
10
127
39
414
0.93
0.12
1.6
1.2
6.6
8.4
u/ml
0.13
15
170
34
361
0.93
0.10
2.6
2.6
0.6
0.7
ug/l
0.11
19
199
227
2248
1.04
0.08
15.1
11.0
41.0
41.0
%
0.02
187
1839
33
348
0.94
0.08
2.0
2.1
—
—
—
0
0
6
73
0.82
0.07
1.7
1.5
—
—
—
0
0
6
73
0.82
0.07
1.8
1.5
—
—
—
0
0
6
73
0.82
0.07
1.8
1.5
—
—
—
0
0
240
2381
1.04
0.07
4.2
4.3
2.9
2.9
mmol/l
0.03
226
2235
74
720
1.04
0.07
3.5
3.1
25.2
34.5
ng/l
0.62
48
415
9
88
1.02
0.07
1.2
1.9
—
—
—
0
0
90
881
1.03
0.06
2.5
2.2
74.5
75.7
nmol/l
0.15
80
793
37
385
0.96
0.06
2.1
2.2
—
—
—
0
0
250
2515
0.96
0.06
9.6
8.4
26.9
27.8
u/l
0.35
240
2451
208
2097
0.97
0.05
4.8
4.8
39.0
38.9
mmol/mol
0.07
196
1995
43
444
0.96
0.05
1.5
1.4
22.7
22.1
nmol/l
0.07
34
379
54
554
0.97
0.04
3.4
2.5
0.2
0.4
e6/l
0.50
44
404
14
132
1.06
0.02
1.6
1.5
—
—
—
0
0
14
148
0.94
0.02
1.1
1.3
—
—
—
0
0
233
2340
0.98
0.02
3.9
3.9
1.5
1.5
mmol/l
0.01
219
2204
175
1760
0.99
0.02
3.3
3.4
—
—
—
0
0
57
563
1.02
0.01
3.6
3.5
0.0
0.0
estimate
0.50
18
208
235
2354
0.99
0.00
15.1
9.8
23.9
20.2
mg/l
0.99
197
1769
7
78
0.89
0.00
1.6
1.5
—
—
—
0
0
7
78
0.89
0.00
1.1
1.1
—
—
—
0
0
6
62
0.97
0.00
1.0
1.4
—
—
—
0
0
6
65
0.92
0.00
1.2
1.3
—
10.8
—
0
10
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
9.0
—
0
9
6
68
0.88
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
10.1
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
235
2350
1.00
0.00
3.9
4.0
4.9
4.8
mmol/l
0.42
220
2221
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
7
72
0.97
0.00
1.1
1.1
—
2.9
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_MENINGOCOCCAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MENINGOCOCCAL | 2.491 [1.73, 3.59] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.475 |
During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 463 females with AB1_MENINGOCOCCAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_MENINGOCOCCAL | 2.574 [1.72, 3.86] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 513 males with AB1_MENINGOCOCCAL died.
Mortality risk
Mortality risk for people of age
years, who have AB1_MENINGOCOCCAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.429% |
| 5 | 1.429% | 2.889% |
| 10 | 3.829% | 7.419% |
| 15 | 7.655% | 14.077% |
| 20 | 13.33% | 23.471% |
Relationships between endpoints
↥Index endpoint: AB1_MENINGOCOCCAL – Meningococcal infection
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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