info icon

Surgical ablation of atrial fibrillation

AF_ABLATION

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Operations: NOMESCO codes ^FPD10

1 out of 7 registries used, show all original rules.

179

4. Check minimum number of events

None

179

5. Include endpoints

None

179

6. Filter based on genotype QC (FinnGen only)

179

Control definitions (FinnGen only)

Control exclude
AF_OPER

Extra metadata

First used in FinnGen datafreeze
DF4

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 179 47 132
Unadjusted period prevalence (%) 0.05 0.02 0.06
Median age at first event (years) 65.14 66.41 64.69

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
165
Matched controls
1651
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FPD10
NOMESCO Finland
Surgical ablation of atrial fibrillation
+∞
238.6
165
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
148.2
128.4
132
43
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
58.2
99.8
128
92
I48
ICD-10 Finland
Atrial fibrillation and flutter
75.0
97.0
153
239
WX872
NOMESCO Finland
Intensive care
58.7
92.4
112
57
B01AA03
ATC
warfarin; systemic
36.5
81.4
141
228
FFM10
NOMESCO Finland
Occlusion or excision of atrial appendage externally with a closing device
619.2
77.7
71
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
33.3
74.7
145
294
I34.1
ICD-10 Finland
Mitral (valve) prolapse
84.6
73.7
80
18
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
167.8
63.2
63
6
TFP20
NOMESCO Finland
Cardiodefibrillation
26.5
63.1
95
80
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
45.3
55.4
68
25
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
15.6
54.0
113
201
C07AB07
ATC
bisoprolol; oral
37.0
51.7
158
625
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
14.5
51.0
109
195
207
Kela drug reimbursment
Chronic arrhythmias
15.0
50.1
100
153
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
13.2
46.1
98
164
FKC50
NOMESCO Finland
Repair of mitral valve for insufficiency using prosthetic chord
552.0
44.4
42
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
11.9
40.6
88
144
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
17.4
40.0
67
62
XF404
NOMESCO Finland
Ambulatory ECG
13.4
34.4
65
76
C01BD01
ATC
amiodarone; systemic
27.2
33.3
46
23
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
52.4
31.5
37
9
FFM30
NOMESCO Finland
Occlusion of atrial appendage internally by internal suture ligation
+∞
31.2
29
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
30.6
30.1
40
17
GD1AA
NOMESCO Finland
Thorax X-ray examination
7.8
29.5
134
586
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
56.2
27.6
32
7
FKC60
NOMESCO Finland
Resection and reconstruction of leaflet of mitral valve for insufficiency
116.5
27.6
29
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.5
25.3
50
60
R4110
NOMESCO Finland
Physiotherapy
6.0
25.2
97
317
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
17.9
24.1
38
27
C03CA01
ATC
furosemide; systemic
5.8
23.4
87
266
WZC30
NOMESCO Finland
Teaching
6.7
21.9
64
142
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.6
21.0
54
99
WX408
NOMESCO Finland
General anesthesy, balanced
5.1
20.9
92
328
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
55.7
20.8
24
5
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
29.0
20.3
27
11
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.1
20.2
84
279
C01AA05
ATC
digoxin; systemic
10.2
19.5
40
50
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
+∞
19.1
18
*
K78
ICPC
Atrial fibrillation/flutter
7.6
18.7
47
82
K83
ICPC
Heart valve disease NOS
37.8
18.5
23
7
B01AF02
ATC
apixaban; oral
7.0
18.0
48
91
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
71.0
17.1
19
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
9.8
16.9
35
44
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
8.9
16.8
37
52
XF400
NOMESCO Finland
ECG with 12 standard connections
4.8
16.0
62
182
WX892
NOMESCO Finland
Monitored bed care
6.2
14.4
41
83
AH3
HP
Treatment of arrhythmias, eg atrial fibrillation, in conjunction with other cardiac surgery
+∞
13.7
13
*
FKC96
NOMESCO Finland
Other repair of mitral valve for insufficiency
+∞
13.7
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
13.7
68
245
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.2
13.6
62
208
B01AE07
ATC
dabigatran etexilate; oral
9.0
13.6
29
38
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
9.4
13.5
28
35
B01AF01
ATC
rivaroxaban; oral
4.8
13.1
48
130
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
75.9
12.8
14
*
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
75.9
12.8
14
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
7.4
12.8
31
50
WX402
NOMESCO Finland
General anaesthesia
4.1
12.5
56
183
C07AA07
ATC
sotalol; systemic
12.5
12.5
22
20
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.1
12.3
55
179
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
18.2
12.0
18
11
K80
ICPC
Cardiac arrhythmia NOS
6.0
12.0
34
68
C01BC04
ATC
flecainide; systemic
8.1
11.6
26
37
K84
ICPC
Heart disease other
11.3
11.4
21
21
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
14.3
10.9
18
14
ZXE20
NOMESCO Finland
More than three and less than five hours
4.0
10.9
49
159
FCA70
NOMESCO Finland
Resection of aortic root and ascending aorta with reimplantation of coronary arteries and use of biological valve prosthesis and tube graft
+∞
10.5
10
*
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
8.2
10.4
23
32
WW502
NOMESCO Finland
Autotransfusion
28.0
10.0
13
5
B01AB05
ATC
enoxaparin; parenteral
3.0
9.7
75
360
AC4
HP
MVP
32.1
9.5
12
*
FKC00
NOMESCO Finland
Repair of mitral valve for insufficiency using ring
105.8
9.5
10
*
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
23.3
9.5
13
6
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
5.9
9.3
26
51
Q23.11
ICD-10 Finland
Bicuspid aortic valve
20.0
9.1
13
7
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
9.1
86
464
Z2221
NOMESCO Finland
Medical doctor
3.0
9.0
65
295
Z95.4
ICD-10 Finland
Presence of other heart-valve replacement
52.9
8.8
10
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
5.8
8.6
24
47
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
5.8
8.6
24
47
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
14.0
8.0
13
10
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
8.7
7.8
16
20
C03DA01
ATC
spironolactone; oral
3.9
7.6
32
96
FL1AC
NOMESCO Finland
Left cardioangiography
14.3
7.5
12
9
FNC10
NOMESCO Finland
Aorto-coronary venous bypass with single distal anastomosis
11.6
7.4
13
12
AH2
HP
Treatment of atrial fibrillation by maze surgery or its modification as the only procedure
+∞
7.3
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.5
7.2
35
119
TFP34
NOMESCO Finland
Electrophysiological investigation
6.4
7.2
18
31
XF640
NOMESCO Finland
NA
8.1
7.1
15
20
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
4.8
7.1
23
54
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
4.7
7.0
23
55
I48.4
ICD-10 Finland
Atypical atrial flutter
41.8
6.8
8
*
PD5BD
NOMESCO Finland
Extensive CT of aorta
9.3
6.7
13
15
Z3231
NOMESCO Finland
Registered nurse
2.6
6.6
59
292
PC1BD
NOMESCO Finland
Extensive CT of thoracic aorta
72.5
6.5
7
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
8.7
6.5
13
16
C01BD07
ATC
dronedarone; oral
18.9
6.3
9
5
XF402
NOMESCO Finland
ECG with work load test
3.1
6.3
36
137
FKC20
NOMESCO Finland
Plastic repair of mitral valve leaflet for insufficiency
27.8
6.3
8
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
27.8
6.3
8
*
FFM20
NOMESCO Finland
Amputation of atrial appendage
+∞
6.3
6
*
TFP35
NOMESCO Finland
Electroanatomical mapping
8.2
6.3
13
17
I50.9
ICD-10 Finland
Heart failure, unspecified
3.3
6.2
31
107
I48.1
ICD-10 Finland
Persistent atrial fibrillation
9.1
6.2
12
14

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: AF_ABLATION – Surgical ablation of atrial fibrillation

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).