This is a non-core endpoint: only basic statistics are computed.
See its core counterpart C3_ANUS_ANALCANAL_EXALLC for full statistics.
Malignant neoplasm of anus and anal canal
C3_ANUS_ANALCANAL
anal neoplasm: A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
157 |
4. Check minimum number of eventsNone |
157 |
5. Include endpointsNone |
157 |
6. Filter based on genotype QC (FinnGen only) |
157 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF9
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of anus and anal canal
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of anus and anal canal, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs, excluding all cancers (controls excluding all cancers)
- Malignant neoplasm
- Any event in cancer register
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 157 | 96 | 61 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 64.77 | 62.45 | 68.42 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 145
- Matched controls
- 1449
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C21.1
ICD-10 Finland
Malignant neoplasm: Anal canal
+∞
120.0
98
*
C21.0
ICD-10 Finland
Malignant neoplasm: Anus, unspecified
+∞
90.2
77
*
8070/3-C21.0
ICD-O-3
Squamous cell carcinoma, NOS, of anus, NOS
+∞
63.2
56
*
130
Kela drug reimbursment
Malignant tumour
25.8
50.0
74
56
WF002
NOMESCO Finland
Radical radiotherapy
40.6
49.2
62
26
8070/3-C21.1
ICD-O-3
Squamous cell carcinoma, NOS, of anal canal
+∞
48.7
44
*
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
20.3
46.9
77
76
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
61.2
45.4
52
13
UJH02
NOMESCO Finland
Anoscopy
26.8
40.3
57
34
A03FA01
ATC
metoclopramide; systemic, rectal
11.2
38.1
95
209
C21.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of rectum, anus and anal canal
+∞
33.6
31
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
46.1
31.5
38
11
JG1CG
NOMESCO Finland
Extensive MRI of rectum
135.5
31.1
32
*
L01BC06
ATC
capecitabine; oral
29.5
30.4
41
19
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
179.4
28.8
29
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
46.8
27.6
33
9
N02AA05
ATC
oxycodone; systemic
8.3
25.6
67
136
C20.99
ICD-10 Finland
Malignant tumor of the rectum other or unspecified histology
243.2
21.2
21
*
JN4BD
NOMESCO Finland
Extensive body CT
7.6
19.7
51
96
JG1BG
NOMESCO Finland
MRI of rectum
64.2
19.5
22
*
D37.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Rectum
45.0
19.2
23
6
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
11.9
19.1
36
39
JHA10
NOMESCO Finland
Biopsy of anal canal
216.6
19.0
19
*
UJG02
NOMESCO Finland
Proctoscopy
26.0
19.0
26
12
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
48.6
17.8
21
5
JHA00
NOMESCO Finland
Anal or perianal incision
57.4
17.5
20
*
UJF32
NOMESCO Finland
Coloscopy
4.7
16.8
78
285
JGB30
NOMESCO Finland
Abdominoperineal excision of rectum
+∞
15.9
15
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
13.0
15.8
28
26
A04AA02
ATC
granisetron; systemic, transdermal
9.5
15.2
32
42
ZX095
NOMESCO Finland
Combined chemoradiotherapy
89.3
14.9
16
*
WB111
NOMESCO Finland
Multiple neoadjuvant cytostatic therapy
165.8
14.7
15
*
A04AA01
ATC
ondansetron; systemic, rectal
9.9
14.7
30
37
ZX070
NOMESCO Finland
Intensity modified radiotherapy
22.9
14.2
20
10
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
31.7
13.3
17
6
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
12.1
11.7
21
20
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
+∞
11.6
11
*
D75
ICPC
Malignant neoplasm colon/rectum
47.2
11.1
13
*
WF001
NOMESCO Finland
Preoperative radiotherapy
64.8
10.8
12
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
35.4
10.5
13
*
TPH07
NOMESCO Finland
Cathetrisation of artery
5.2
10.2
33
78
ZX090
NOMESCO Finland
Other technic of radiotherapy
10.6
9.6
18
19
C21.2
ICD-10 Finland
Malignant neoplasm: Cloacogenic zone
+∞
9.5
9
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
7.2
9.2
22
35
WW500
NOMESCO Finland
Blood transfusion
9.6
9.1
18
21
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.3
8.7
23
42
8140/3-C21.1
ICD-O-3
Adenocarcinoma, NOS, of anal canal
+∞
8.4
8
*
XX3DW
NOMESCO Finland
Time consuming IT work
4.3
8.4
32
89
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
18.5
8.2
12
7
Z93.3
ICD-10 Finland
Colostomy status
35.5
8.2
10
*
ULA02
NOMESCO Finland
Kolposcopy
4.7
7.9
27
67
Z51.5
ICD-10 Finland
Palliative care
5.5
7.9
23
48
C20
ICD-10 Finland
Malignant neoplasm of rectum
26.6
7.7
10
*
P01AB01
ATC
metronidazole; oral, rectal
2.7
7.6
78
436
JG1DG
NOMESCO Finland
Very extensive MRI of rectum
84.1
7.5
8
*
JGB36
NOMESCO Finland
Wide excision of rectum
84.1
7.5
8
*
YL1CD
NOMESCO Finland
Very extensive CT examination of pelvis for dose design of radiotherapy
84.1
7.5
8
*
JN4AD
NOMESCO Finland
Body CT examination
4.6
7.3
25
62
JF1CM
NOMESCO Finland
Small bowel extensive MRI with with high intensity magnet
+∞
7.3
7
*
JFF23
NOMESCO Finland
Transversostomy
31.7
7.2
9
*
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
31.7
7.2
9
*
H02AB02
ATC
dexamethasone; systemic
3.7
7.0
31
98
TPX10
NOMESCO Finland
Implantation of vascular injection port
9.0
7.0
14
17
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
8.5
6.8
14
18
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.7
6.7
30
96
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
10.8
6.7
12
12
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.6
6.5
61
318
WX600
NOMESCO Finland
Single shot through catheter
19.0
6.3
9
5
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.6
6.3
28
89
R50.9
ICD-10 Finland
Fever, unspecified
3.3
6.3
34
124
JG1CM
NOMESCO Finland
Extensive MRI of rectum (more than 1.5 T)
+∞
6.3
6
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
8.3
6.3
13
17
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
6.6
6.2
15
25
D18
ICPC
Change in faeces/bowel movements
13.3
6.2
10
8
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
10.7
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
95
181
11.76
55.89
4.8
4.4
5.0
69.0
ug/l
0.85
76
152
121
731
3.86
12.24
16.9
9.7
3.7
4.1
e9/l
0.84
106
642
91
469
3.24
11.84
7.8
3.6
2.4
2.4
mmol/l
0.64
82
414
64
296
2.96
9.64
2.4
2.0
3.3
3.3
mg/l
0.00
48
251
41
153
3.27
8.87
2.3
2.5
12.1
9.5
umol/l
0.15
32
134
63
308
2.75
8.35
5.2
2.1
—
—
—
0
0
30
97
3.59
8.07
2.2
1.5
—
—
—
0
0
21
54
4.33
7.72
2.0
1.6
6.1
6.8
ug/l
0.04
21
49
98
618
2.56
7.44
11.2
5.6
1.2
1.2
mmol/l
0.57
90
557
96
604
2.52
7.26
7.2
3.9
—
—
—
0
0
101
665
2.45
6.70
12.7
6.6
1.2
1.2
mmol/l
0.74
89
563
59
322
2.33
5.84
1.5
1.6
19.0
21.6
nmol/l
0.52
49
262
43
210
2.44
5.41
3.6
3.1
1.2
1.8
e6/l
0.54
26
115
30
129
2.64
4.88
2.7
2.2
31.6
28.7
u/l
0.27
25
104
44
235
2.21
4.43
3.1
2.8
1.1
0.8
e6/l
0.15
27
135
33
159
2.36
4.21
14.4
6.7
12.3
11.6
kpa
0.47
33
152
33
159
2.36
4.21
14.5
6.7
5.2
5.1
kpa
0.58
33
152
79
536
1.95
4.11
2.1
2.0
84.4
95.4
pmol/l
1.30
43
261
40
215
2.15
3.93
2.5
1.9
—
—
—
0
0
19
72
2.86
3.90
2.1
1.7
—
—
—
0
0
31
153
2.28
3.73
2.2
1.8
—
—
—
0
0
73
495
1.89
3.70
6.0
3.2
—
—
—
0
0
75
515
1.87
3.64
3.4
2.7
236.2
123.5
ug/l
1.40
70
468
60
384
1.91
3.61
5.1
3.1
0.4
0.4
e6/l
0.12
48
288
20
83
2.62
3.47
19.4
8.6
92.2
94.5
%
0.30
20
83
30
155
2.16
3.22
2.2
1.9
—
—
—
0
0
27
139
2.14
2.92
3.3
4.8
225.4
246.9
u/l
0.26
27
132
11
36
3.21
2.87
1.7
1.4
—
—
—
0
0
36
209
1.94
2.82
2.5
1.9
30.2
29.3
s
0.32
36
201
24
124
2.10
2.57
7.6
3.5
2.2
2.1
mmol/l
0.08
18
99
16
71
2.40
2.44
12.3
6.1
24.2
24.9
mmol/l
0.40
16
71
45
295
1.74
2.37
2.0
1.7
1.1
1.2
mg/l
0.10
35
238
6
13
4.75
2.29
2.2
1.3
58.8
52.5
u/l
—
6
8
5
9
5.69
2.23
1.0
2.7
—
—
—
0
0
9
31
3.02
2.11
2.8
1.5
—
—
—
0
0
24
134
1.93
2.10
6.3
3.4
—
—
—
0
0
15
70
2.26
2.06
1.3
1.2
—
—
—
0
0
7
21
3.44
1.99
2.3
1.4
—
—
—
0
0
10
39
2.67
1.96
1.6
1.9
—
—
—
0
0
11
46
2.50
1.90
2.6
2.1
—
—
—
0
0
9
36
2.59
1.77
1.2
1.3
—
—
—
0
0
8
30
2.75
1.75
1.0
1.5
—
—
—
0
0
8
30
2.75
1.75
1.0
1.5
—
—
—
0
0
112
1252
0.63
1.74
4.6
4.8
1.5
1.5
mmol/l
0.56
102
1142
126
1115
1.66
1.74
38.5
15.7
36.6
39.5
%
3.32
97
780
17
90
2.00
1.73
7.5
6.8
24.2
24.8
mmol/l
0.40
17
85
108
1213
0.65
1.65
6.4
6.2
40.5
40.3
mmol/mol
0.05
96
1117
13
65
2.09
1.53
12.5
3.3
25.2
24.1
mmol/l
0.62
13
58
138
1268
1.73
1.43
35.9
14.9
31.2
23.8
mg/l
2.08
126
1014
10
193
0.49
1.41
1.3
1.4
—
—
—
0
0
18
106
1.79
1.36
5.7
3.2
58.8
60.8
ml/min/173m2
—
8
42
67
538
1.43
1.36
2.7
2.4
72.1
77.8
nmol/l
1.08
57
469
37
267
1.50
1.29
3.4
3.4
94.1
137.2
ng/l
0.28
32
212
8
35
2.35
1.29
1.5
1.3
—
—
—
0
0
27
183
1.57
1.24
1.3
1.3
—
—
—
0
0
110
977
1.42
1.19
4.5
4.4
27.0
13.0
mm/h
6.07
102
887
36
265
1.47
1.14
1.8
1.7
903.2
1169.6
nmol/l
1.41
27
200
116
1259
0.70
1.11
4.5
4.8
4.7
4.7
mmol/l
0.15
106
1159
12
67
1.86
1.08
1.9
3.4
24.9
24.9
mmol/l
0.01
12
67
7
33
2.17
1.07
1.1
1.2
—
—
—
0
0
131
1211
1.49
1.06
33.4
14.1
79.2
76.6
ml/min/173m2
0.68
118
1003
9
46
2.01
1.05
2.6
1.9
—
—
—
0
0
17
107
1.66
1.05
2.6
2.0
196.7
167.8
ng/l
0.16
12
94
9
48
1.93
1.02
1.1
1.2
—
—
—
0
0
9
48
1.93
1.02
1.1
1.2
—
—
—
0
0
120
1290
0.70
1.01
5.1
5.4
2.8
2.8
mmol/l
0.24
108
1174
11
61
1.86
1.01
1.3
2.4
—
—
—
0
0
117
1262
0.71
1.00
5.1
4.9
6.0
6.0
mmol/l
0.17
104
1148
111
1207
0.73
0.99
4.0
4.3
1.4
1.3
mmol/l
0.64
99
1095
6
29
2.11
0.90
1.0
1.1
—
—
—
0
0
6
29
2.11
0.90
1.3
3.7
13.1
41.5
u/ml
—
6
29
8
42
1.95
0.90
2.5
1.8
—
—
—
0
0
76
657
1.30
0.88
7.1
5.3
0.0
0.0
estimate
0.00
14
117
77
667
1.30
0.87
5.7
3.9
0.0
0.0
estimate
0.00
15
112
36
282
1.36
0.81
1.5
1.8
394.6
448.6
pmol/l
0.61
31
230
11
66
1.72
0.81
7.6
2.3
0.8
1.1
%
0.77
11
66
24
313
0.72
0.71
2.9
4.6
14.2
21.1
%
—
8
159
51
429
1.28
0.70
2.3
3.2
1502.5
1494.9
ng/l
0.00
46
363
74
654
1.25
0.67
5.8
3.9
0.0
0.0
estimate
0.00
14
120
9
64
1.43
0.52
1.1
1.3
—
—
—
0
0
5
84
0.58
0.47
2.2
1.9
—
—
—
0
0
5
33
1.53
0.41
1.4
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
139
1350
1.26
0.35
40.5
17.7
80.9
78.0
umol/l
0.33
139
1350
40
357
1.16
0.30
6.9
4.1
0.0
0.0
estimate
0.00
14
113
7
55
1.29
0.30
1.7
1.2
—
—
—
0
0
21
247
0.83
0.29
1.6
1.3
29.8
27.1
iu/ml
—
5
87
8
62
1.31
0.28
1.8
1.4
—
—
—
0
0
20
233
0.84
0.26
1.5
3.0
0.4
0.8
ug/l
—
9
163
114
1176
0.89
0.23
5.6
4.7
2.1
3.0
mu/l
0.45
102
1043
5
40
1.26
0.22
1.6
1.9
—
—
—
0
0
5
42
1.20
0.21
2.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
13
110
1.20
0.18
4.1
1.8
512.2
355.4
nmol/l
1.10
13
98
15
131
1.16
0.15
1.9
2.6
5.1
5.1
ug/l
—
10
119
24
262
0.90
0.13
1.2
1.2
0.3
1.6
u/ml
—
5
74
45
431
1.06
0.09
4.9
3.6
18.8
10.4
mg/mmol
0.56
27
253
98
960
1.06
0.09
4.6
3.9
15.6
14.9
pmol/l
0.62
88
856
7
67
1.05
0.08
1.3
2.4
39.3
39.9
u/l
—
7
61
7
81
0.86
0.07
8.1
3.3
4.7
5.1
kpa
—
7
72
13
118
1.11
0.07
1.1
1.7
1.6
1.6
%
0.03
13
102
67
684
0.96
0.05
3.0
2.7
—
—
—
0
0
52
532
0.97
0.04
4.0
3.9
225.2
33.1
ng/l
0.58
37
388
38
387
0.98
0.01
3.1
5.0
1.3
2.4
ug/l
1.29
30
344
18
181
0.99
0.00
5.4
4.5
35.3
31.8
%
0.42
12
115
50
505
0.99
0.00
6.7
4.1
—
—
—
0
0
17
165
1.03
0.00
12.6
8.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
11.2
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
92.0
—
0
5
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: C3_ANUS_ANALCANAL – Malignant neoplasm of anus and anal canal
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).