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Neuroendocrine tumor and carcinoma of stomach, excluding all cancers (controls excluding all cancers)

Endpoint Browser PheWeb

C3_STOMACH_NEUROENDOCRINE_EXALLC

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 — C16
  • Cancer registry: Morphology ICD-O-3 — 8240|824[2-4]|8246|8249
  • Cancer registry: Behaviour codes — 3

1 out of 7 registries used, show all original rules.

160

4. Check minimum number of events

None

160

5. Include endpoints

None

160

6. Filter based on genotype QC (FinnGen only)

160

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

↥

List of similar endpoints to Neuroendocrine tumor and carcinoma of stomach, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 160 84 76
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 62.11 59.36 65.16

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
149
Matched controls
1491
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K29.4
ICD-10 Finland
Chronic atrophic gastritis
110.3
82.7
86
18
8240/3-C16.9
ICD-O-3
Neuroendocrine tumor, NOS, of stomach, NOS
+∞
78.2
68
*
B03BA03
ATC
hydroxocobalamin; parenteral
51.2
78.0
97
52
107
Kela drug reimbursment
Pernicious anaemia
61.2
59.1
68
20
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
21.5
56.7
124
279
B81
ICPC
Anaemia vit B12/folate deficiency
40.1
51.3
65
28
8240/3-C16.2
ICD-O-3
Neuroendocrine tumor, NOS, of body of stomach
+∞
46.3
42
*
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
43.1
46.1
57
21
D37.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Stomach
534.2
42.4
40
*
130
Kela drug reimbursment
Malignant tumour
+∞
26.9
25
*
JDA05
NOMESCO Finland
Endoscopic polypectomy in stomach or pylorus
74.4
22.6
25
*
C16.9
ICD-10 Finland
Malignant neoplasm: Stomach, unspecified
+∞
15.9
15
*
E34.0
ICD-10 Finland
Carcinoid syndrome
+∞
15.9
15
*
UJD02
NOMESCO Finland
Gastroscopy
10.9
14.5
28
31
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
+∞
13.8
13
*
A50
ICPC
General and Unspecified, Medication/prescr/renewal
13.4
12.3
21
18
JDA45
NOMESCO Finland
Endoscopic mucosal or submucosal resection in stomach or pylorus
+∞
10.5
10
*
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
35.3
10.5
13
*
UJF32
NOMESCO Finland
Coloscopy
3.5
10.5
59
233
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
21.9
10.0
14
7
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
19.1
9.6
14
8
H02AB02
ATC
dexamethasone; systemic
23.5
9.5
13
6
8240/3-C16.0
ICD-O-3
Neuroendocrine tumor, NOS, of cardia, NOS
+∞
9.5
9
*
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
29.5
8.6
11
*
H01CB02
ATC
octreotide; parenteral
+∞
8.4
8
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
8.4
8
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.3
8.2
25
55
A10AE04
ATC
insulin glargine; parenteral
4.7
7.9
27
67
D64.9
ICD-10 Finland
Anaemia, unspecified
4.5
7.6
27
70
C61
ICD-10 Finland
Malignant neoplasm of prostate
84.1
7.5
8
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
7.3
7
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
7.3
7
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
7.3
7
*
-50
ICPC
Medication/prescr/renewal
6.7
7.0
17
28
K31.7
ICD-10 Finland
Polyp of stomach and duodenum
42.0
6.8
8
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
4.9
6.7
21
48
H03AA01
ATC
levothyroxine sodium; systemic
2.7
6.5
50
232
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
19.0
6.3
9
5
S50
ICPC
Skin, Medication/prescr/renewal
28.0
6.3
8
*
8249/3-C16.9
ICD-O-3
Neuroendocrine tumor, grade 2 of stomach, NOS
+∞
6.3
6
*
8249/3-C16.2
ICD-O-3
Neuroendocrine tumor, grade 2 of body of stomach
+∞
6.3
6
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
6.3
6
*
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
+∞
6.3
6
*
L01BC06
ATC
capecitabine; oral
+∞
6.3
6
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
6.3
6
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
6.2
40
164
JN4AD
NOMESCO Finland
Body CT examination
6.3
6.0
15
26

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
61
30
32.25
84.44
2.3
1.3
—
—
—
0
0
87
173
9.83
48.13
3.3
1.1
—
—
—
0
0
25
0
+∞
26.82
3.1
0.0
273.9
—
pmol/l
—
19
0
75
318
3.56
13.93
3.2
2.0
3.5
3.3
mg/l
0.27
67
264
32
74
5.16
13.60
2.9
1.3
13.8
6.5
ug/l
0.38
26
55
95
531
2.94
10.13
5.8
3.2
34.4
35.4
g/l
0.89
87
493
91
498
2.92
10.08
7.7
9.5
1.1
1.3
inr
2.10
22
137
88
487
2.79
9.33
4.5
2.6
86.7
115.8
ug/l
0.49
81
444
47
185
3.18
9.33
2.7
2.3
12.3
13.1
umol/l
0.12
42
168
42
158
3.25
8.95
2.5
2.4
19.3
22.0
%
0.28
36
140
96
570
2.71
8.64
3.0
2.0
81.8
93.7
pmol/l
1.36
60
282
102
638
2.65
8.05
7.4
3.7
11.1
11.8
umol/l
0.42
96
593
59
284
2.71
7.97
2.5
1.7
650.0
435.2
pmol/l
1.14
48
232
100
650
2.44
6.82
10.2
6.2
4.6
4.3
e9/l
0.42
87
554
94
595
2.41
6.80
6.0
5.4
1.6
1.9
e9/l
2.50
84
520
87
544
2.31
6.33
6.2
5.4
60.8
57.5
%
1.51
82
498
69
392
2.34
6.27
6.3
5.3
—
—
—
0
0
88
561
2.26
6.01
6.0
4.9
1.2
1.2
mmol/l
0.13
81
493
59
320
2.34
5.91
1.7
1.5
26.2
21.4
nmol/l
1.16
53
268
30
124
2.75
5.27
1.4
1.2
—
—
—
0
0
66
391
2.17
5.23
2.2
1.6
—
—
—
0
0
88
587
2.11
5.08
6.1
5.3
0.6
0.6
e9/l
0.18
79
502
88
588
2.10
5.05
6.2
5.3
0.0
0.0
e9/l
0.32
79
503
60
347
2.17
5.02
2.8
2.1
—
—
—
0
0
89
603
2.07
4.85
6.6
5.5
0.2
0.2
e9/l
0.14
80
523
23
86
2.96
4.83
1.3
1.1
—
—
—
0
0
50
275
2.19
4.70
2.1
1.7
1065.0
1200.9
nmol/l
0.56
37
207
61
366
2.08
4.56
4.0
3.3
7.4
7.4
ph
0.03
14
58
64
392
2.05
4.52
3.8
2.0
2.3
2.4
mmol/l
0.21
54
315
24
98
2.70
4.29
1.1
1.4
—
—
—
0
0
53
308
2.08
4.27
4.6
3.8
—
—
—
0
0
12
32
3.97
4.17
1.3
1.2
274.4
319.1
ug/g
—
7
17
23
94
2.69
4.10
1.1
1.6
—
—
—
0
0
30
149
2.25
3.55
2.3
2.4
1.7
1.6
%
0.11
25
136
52
330
1.85
3.13
2.1
2.5
334.0
9038.2
umol/l
2.07
41
285
14
52
2.85
2.97
4.0
4.5
—
—
—
0
0
44
277
1.81
2.68
1.3
1.2
—
—
—
0
0
106
853
1.72
2.64
5.7
4.3
—
—
—
0
0
36
214
1.88
2.62
1.2
1.3
15.0
42.8
iu/ml
—
10
70
38
230
1.86
2.61
1.4
1.3
2.7
2.7
g/l
0.02
23
140
56
382
1.72
2.58
3.6
3.3
—
—
—
0
0
27
146
2.02
2.57
1.3
1.4
324.4
614.4
titre
—
9
39
6
11
5.62
2.56
1.7
1.6
2.7
338.9
u/ml
—
6
11
5
7
7.32
2.56
1.0
1.4
—
—
—
0
0
13
52
2.63
2.42
1.2
1.3
—
—
—
0
0
23
120
2.07
2.40
4.1
3.5
—
—
—
0
0
5
8
6.41
2.39
1.2
1.1
—
—
—
0
0
38
241
1.76
2.23
3.8
2.2
2.5
2.4
mmol/l
0.68
30
203
55
388
1.64
2.18
3.7
4.1
—
—
—
0
0
10
37
2.82
2.14
1.1
1.0
—
—
—
0
0
41
274
1.67
1.99
1.4
1.7
1.5
1.1
mg/l
0.19
30
217
19
100
2.02
1.95
2.8
4.1
89.8
82.4
ng/l
0.23
19
88
59
434
1.57
1.94
4.0
3.0
6.3
7.6
mmol/l
1.06
45
362
11
46
2.49
1.89
1.5
1.7
—
—
—
0
0
21
116
1.93
1.89
1.3
1.6
—
—
—
0
0
21
117
1.91
1.85
2.0
2.5
68.6
64.8
e9/l
0.23
15
90
38
254
1.65
1.84
1.4
1.2
0.7
1.7
u/ml
—
8
75
5
12
4.26
1.83
6.4
3.5
—
—
—
0
0
12
54
2.32
1.79
1.1
1.5
—
—
—
0
0
9
36
2.59
1.77
1.1
1.1
—
—
—
0
0
79
630
1.50
1.76
4.7
3.8
0.0
0.0
estimate
0.00
14
97
112
962
1.55
1.73
5.8
3.7
15.3
14.9
pmol/l
1.03
102
856
24
143
1.80
1.73
2.9
1.7
—
—
—
0
0
78
622
1.50
1.72
5.5
5.2
0.0
0.0
estimate
0.00
15
101
38
258
1.62
1.72
5.6
4.0
120.8
169.8
ng/l
0.23
31
213
77
614
1.49
1.70
4.6
3.8
0.0
0.0
estimate
0.00
14
101
60
455
1.51
1.68
4.8
3.8
59.3
6.1
mg/mmol
0.53
35
277
8
31
2.66
1.68
1.1
1.1
—
—
—
0
0
6
19
3.24
1.67
1.3
1.5
—
—
—
0
0
12
56
2.24
1.65
5.6
8.4
—
—
—
0
0
29
423
0.62
1.56
3.8
3.3
—
—
—
0
0
16
88
1.91
1.47
1.1
1.3
—
—
—
0
0
55
424
1.45
1.38
4.1
3.1
68.3
196.9
mg/l
0.38
33
266
6
23
2.67
1.38
1.2
1.1
—
—
—
0
0
10
47
2.20
1.37
3.6
5.3
24.7
26.0
mmol/l
—
10
41
66
528
1.43
1.36
11.7
8.4
0.0
0.0
e9/l
0.44
56
416
35
247
1.53
1.35
5.4
5.1
—
—
—
0
0
15
84
1.87
1.32
2.3
2.4
—
—
—
0
0
69
562
1.40
1.27
3.7
3.9
194.0
42.9
ng/l
0.45
52
409
28
191
1.56
1.25
1.7
1.8
29.1
29.1
s
0.00
28
185
36
262
1.48
1.20
2.7
2.2
4.6
4.7
e6/l
0.01
29
224
26
177
1.56
1.17
2.5
1.9
—
—
—
0
0
56
446
1.39
1.15
5.6
3.7
421.4
113.2
e6/l
0.35
41
319
22
146
1.59
1.10
1.5
1.5
—
—
—
0
0
28
197
1.51
1.10
1.4
1.3
1.2
16.9
u/ml
—
8
72
14
83
1.75
1.05
1.1
1.2
—
—
—
0
0
60
492
1.35
1.02
3.5
3.5
—
—
—
0
0
0
29
0.00
0.99
0.0
1.2
—
—
—
0
0
43
336
1.38
0.98
4.0
2.9
—
—
—
0
0
117
1264
0.72
0.98
5.4
4.7
1.4
1.5
mmol/l
1.07
106
1154
48
382
1.37
0.98
4.6
3.1
677.0
216.6
e6/l
0.31
38
290
16
101
1.65
0.98
4.7
7.5
—
—
—
0
0
42
330
1.37
0.93
4.0
3.5
—
—
—
0
0
17
111
1.59
0.92
2.0
1.4
—
—
—
0
0
11
64
1.77
0.88
1.2
1.2
—
—
—
0
0
113
1221
0.75
0.88
4.7
4.3
1.3
1.3
mmol/l
0.09
100
1105
15
96
1.62
0.88
2.3
2.4
1.2
1.2
mmol/l
0.54
15
80
38
298
1.36
0.85
4.4
3.6
—
—
—
0
0
18
122
1.54
0.84
1.6
1.6
—
—
—
0
0
32
244
1.39
0.84
2.7
2.7
527.3
550.2
mosm/kgh2o
0.34
25
199
20
139
1.50
0.84
4.9
5.8
-0.3
1.5
mmol/l
1.11
13
105
13
81
1.66
0.84
1.4
1.2
—
—
—
0
0
41
328
1.34
0.81
5.8
4.0
0.0
0.0
estimate
0.00
14
101
119
1271
0.75
0.79
5.4
4.8
4.2
4.6
mmol/l
3.02
108
1164
6
34
1.79
0.77
1.0
1.1
—
—
—
0
0
0
28
0.00
0.77
0.0
1.2
—
2.5
—
0
22
0
28
0.00
0.77
0.0
1.4
—
96.8
—
0
22
17
117
1.51
0.75
2.5
2.8
4.3
4.4
kpa
0.06
17
111
122
1296
0.75
0.75
6.1
5.4
2.4
2.7
mmol/l
2.78
111
1184
5
26
1.95
0.71
1.0
1.1
—
—
—
0
0
7
41
1.74
0.71
1.6
1.7
0.2
0.2
g/l
—
7
41
25
189
1.38
0.70
18.1
23.2
1.4
1.3
inr
—
7
22
14
94
1.54
0.69
3.9
3.6
—
—
—
0
0
132
1246
1.34
0.68
22.6
12.7
27.0
22.5
mg/l
0.83
118
944
7
43
1.66
0.67
1.6
1.7
1.2
1.2
g/l
—
7
43
12
78
1.58
0.67
3.8
3.8
—
—
—
0
0
11
71
1.59
0.64
4.6
6.3
25.0
25.3
mmol/l
0.08
11
71
43
358
1.28
0.63
4.0
2.9
2.5
0.6
e6/l
0.83
32
259
0
20
0.00
0.61
0.0
1.0
—
—
—
0
0
6
35
1.74
0.58
1.7
1.4
—
—
—
0
0
6
37
1.65
0.56
1.0
1.7
—
—
—
0
0
9
61
1.50
0.55
1.2
1.3
—
—
—
0
0
100
925
1.22
0.54
4.3
4.0
—
—
—
0
0
9
62
1.48
0.54
5.2
8.1
24.1
25.1
mmol/l
—
9
53
19
145
1.35
0.51
2.7
3.6
—
—
—
0
0
124
1180
1.23
0.46
6.9
4.6
1.8
2.0
mu/l
0.54
116
1044
5
31
1.63
0.43
4.6
2.0
—
—
—
0
0
5
32
1.58
0.42
1.2
2.8
—
—
—
0
0
0
15
0.00
0.41
0.0
2.7
—
563.6
—
0
10
13
98
1.36
0.39
1.5
1.4
—
—
—
0
0
31
265
1.21
0.37
2.3
2.8
0.9
0.8
ug/l
0.15
21
172
6
46
1.32
0.33
1.0
1.1
—
—
—
0
0
10
75
1.36
0.31
5.8
8.0
94.0
93.3
%
—
10
75
7
55
1.29
0.30
5.1
1.9
—
—
—
0
0
10
77
1.32
0.27
1.4
2.3
1.1
1.3
%
—
10
77
5
37
1.36
0.24
1.4
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
1.0
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
102
1057
0.90
0.21
31.4
16.3
328.5
331.7
g/l
1.95
102
1050
136
1388
0.87
0.21
35.5
18.7
128.9
135.8
g/l
5.73
136
1354
136
1330
1.15
0.21
26.3
15.4
139.2
139.9
mmol/l
2.25
136
1279
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
136
1387
0.87
0.20
35.1
18.5
29.7
30.4
pg
3.22
136
1355
136
1332
1.14
0.19
27.1
15.0
79.5
80.0
umol/l
0.05
136
1332
136
1386
0.87
0.19
35.1
18.6
90.2
91.4
fl
2.30
136
1354
32
292
1.12
0.18
5.5
4.6
—
—
—
0
0
136
1333
1.14
0.18
26.4
15.5
3.9
4.0
mmol/l
2.52
136
1280
130
1325
0.90
0.16
21.0
11.9
—
—
—
0
0
13
113
1.16
0.13
3.8
2.8
—
—
—
0
0
11
96
1.16
0.10
4.7
3.0
—
—
—
0
0
5
64
0.77
0.08
2.4
2.9
4.4
4.4
pmol/l
—
5
54
8
78
1.03
0.07
4.0
4.0
—
—
—
0
0
124
1228
1.04
0.04
9.1
6.3
43.9
40.8
mmol/mol
2.05
117
1135
30
294
1.03
0.00
5.5
3.8
1.0
1.0
kg/l
—
7
48
127
1273
0.99
0.00
6.5
4.9
6.5
6.1
mmol/l
1.85
121
1148
111
1108
1.01
0.00
24.4
13.9
37.6
40.2
%
1.30
74
747
46
462
0.99
0.00
4.5
4.0
6.4
2.1
ug/l
0.62
40
407
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
69
1.02
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
8.7
—
975.2
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
212.5
—
0
5
0
6
0.00
0.00
0.0
10.7
—
1723.0
—
0
6
0
6
0.00
0.00
0.0
1.0
—
1.6
—
0
6
5
57
0.87
0.00
20.4
10.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: C3_STOMACH_NEUROENDOCRINE_EXALLC – Neuroendocrine tumor and carcinoma of stomach, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).