info icon

Neuroendocrine tumor and carcinoma of stomach

C3_STOMACH_NEUROENDOCRINE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C16
  • Cancer registry: Morphology ICD-O-3 8240|824[2-4]|8246|8249
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

160

4. Check minimum number of events

None

160

5. Include endpoints

None

160

6. Filter based on genotype QC (FinnGen only)

160

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Neuroendocrine tumor and carcinoma of stomach based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 160 84 76
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 62.11 59.36 65.16

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
149
Matched controls
1491
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K29.4
ICD-10 Finland
Chronic atrophic gastritis
132.6
85.0
86
15
8240/3-C16.9
ICD-O-3
Neuroendocrine tumor, NOS, of stomach, NOS
+∞
78.1
68
*
B03BA03
ATC
hydroxocobalamin; parenteral
49.2
77.1
97
54
107
Kela drug reimbursment
Pernicious anaemia
94.3
63.9
68
13
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
18.3
51.3
124
317
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
69.8
51.0
57
13
B81
ICPC
Anaemia vit B12/folate deficiency
33.9
49.0
65
33
8240/3-C16.2
ICD-O-3
Neuroendocrine tumor, NOS, of body of stomach
+∞
46.3
42
*
D37.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Stomach
135.2
38.9
40
*
JDA05
NOMESCO Finland
Endoscopic polypectomy in stomach or pylorus
+∞
26.9
25
*
UJD02
NOMESCO Finland
Gastroscopy
9.1
13.2
28
37
E34.0
ICD-10 Finland
Carcinoid syndrome
55.1
13.1
15
*
C16.9
ICD-10 Finland
Malignant neoplasm: Stomach, unspecified
55.1
13.1
15
*
A50
ICPC
General and Unspecified, Medication/prescr/renewal
10.9
11.2
21
22
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
35.3
10.5
13
*
JDA45
NOMESCO Finland
Endoscopic mucosal or submucosal resection in stomach or pylorus
106.4
9.5
10
*
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
23.5
9.5
13
6
8240/3-C16.0
ICD-O-3
Neuroendocrine tumor, NOS, of cardia, NOS
+∞
9.5
9
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.2
8.0
25
56
UJF32
NOMESCO Finland
Coloscopy
2.8
7.5
59
280
S50
ICPC
Skin, Medication/prescr/renewal
84.0
7.5
8
*
130
Kela drug reimbursment
Malignant tumour
4.3
6.9
25
66
H01CB02
ATC
octreotide; parenteral
42.0
6.8
8
*
A55
ICPC
General and Unspecified, Local injection/infiltration
23.8
6.8
9
*
K31.7
ICD-10 Finland
Polyp of stomach and duodenum
28.0
6.3
8
*
JDA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in stomach or pylorus
+∞
6.3
6
*
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
+∞
6.3
6
*
8249/3-C16.2
ICD-O-3
Neuroendocrine tumor, grade 2 of body of stomach
+∞
6.3
6
*
8249/3-C16.9
ICD-O-3
Neuroendocrine tumor, grade 2 of stomach, NOS
+∞
6.3
6
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
6.9
6.0
14
22

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
87
192
8.74
43.07
3.3
1.2
—
—
—
0
0
61
127
7.15
30.65
2.3
1.4
—
—
—
0
0
75
314
3.61
14.28
3.2
2.0
3.5
3.4
mg/l
0.09
67
270
96
548
2.88
9.70
3.0
1.9
81.8
97.1
pmol/l
1.96
60
267
12
14
9.19
9.47
1.7
1.4
11.8
15.7
ug/l
1.64
12
14
88
501
2.68
8.62
4.5
2.4
86.7
139.0
ug/l
1.07
81
451
95
576
2.60
7.97
5.8
4.1
34.4
34.9
g/l
0.38
87
538
47
208
2.78
7.40
2.7
2.0
12.3
12.8
umol/l
0.08
42
190
91
554
2.49
7.38
7.7
8.3
1.1
1.3
inr
1.00
22
166
59
307
2.46
6.59
2.5
1.8
650.0
466.0
pmol/l
0.91
48
251
42
186
2.71
6.54
2.5
2.1
19.3
21.7
%
0.23
36
163
59
324
2.30
5.71
1.7
1.5
26.2
21.6
nmol/l
1.09
53
261
69
417
2.15
5.19
6.3
5.2
—
—
—
0
0
94
641
2.13
5.14
6.0
5.9
1.6
1.8
e9/l
1.55
84
572
50
272
2.22
4.84
2.1
1.7
1065.0
1225.7
nmol/l
0.71
37
205
87
592
2.03
4.61
6.2
5.9
60.8
58.2
%
1.06
82
556
102
736
2.06
4.58
7.4
6.2
11.1
11.7
umol/l
0.35
96
693
100
733
1.97
4.10
10.2
10.0
4.6
4.2
e9/l
0.73
87
646
88
620
1.93
4.04
6.0
5.8
1.2
1.2
mmol/l
0.22
81
551
32
156
2.31
3.96
2.9
4.5
13.8
12.8
ug/l
0.04
26
126
88
629
1.89
3.78
6.1
5.8
0.6
0.6
e9/l
0.31
79
549
88
630
1.88
3.75
6.2
5.9
0.0
0.0
e9/l
0.07
79
555
12
36
3.52
3.55
1.3
1.4
274.4
290.2
ug/g
—
7
22
89
647
1.85
3.55
6.6
6.1
0.2
0.2
e9/l
0.30
80
577
30
159
2.09
3.01
2.3
2.8
1.7
1.7
%
0.15
25
148
59
395
1.78
2.96
4.0
2.9
6.3
7.6
mmol/l
1.08
45
322
11
36
3.21
2.87
1.5
1.6
—
—
—
0
0
64
445
1.73
2.79
3.7
3.3
2.3
2.3
mmol/l
0.14
54
381
61
422
1.72
2.69
4.0
4.1
7.4
7.4
ph
0.00
14
85
30
166
1.99
2.68
1.4
1.2
—
—
—
0
0
52
345
1.75
2.65
2.1
3.0
334.0
9334.2
umol/l
2.26
41
287
60
418
1.70
2.56
4.8
3.8
59.3
7.5
mg/mmol
0.51
35
255
36
216
1.86
2.54
1.2
1.3
15.0
41.1
iu/ml
—
10
77
24
125
2.08
2.52
1.1
1.4
—
—
—
0
0
60
420
1.69
2.50
2.8
2.2
—
—
—
0
0
10
34
3.07
2.46
1.1
1.1
—
—
—
0
0
23
121
2.05
2.35
1.1
1.5
—
—
—
0
0
27
152
1.93
2.30
1.3
1.4
324.4
596.8
titre
—
9
38
5
9
5.69
2.23
1.0
1.2
—
—
—
0
0
53
370
1.65
2.19
4.6
4.4
—
—
—
0
0
55
388
1.64
2.18
4.1
3.0
68.3
48.4
mg/l
0.21
33
242
21
110
2.05
2.18
2.0
2.8
68.6
71.7
e9/l
0.17
15
85
56
398
1.63
2.15
3.6
3.3
—
—
—
0
0
14
62
2.38
2.14
4.0
3.5
—
—
—
0
0
9
31
3.01
2.11
1.1
1.2
—
—
—
0
0
106
881
1.60
2.08
5.7
4.6
—
—
—
0
0
38
246
1.71
2.07
5.6
3.3
120.8
136.6
ng/l
0.08
31
203
23
128
1.93
2.03
4.1
4.1
—
—
—
0
0
112
946
1.61
2.02
5.8
3.9
15.3
15.0
pmol/l
0.75
102
838
19
99
2.04
2.00
2.8
3.2
89.8
76.5
ng/l
0.48
19
89
15
71
2.23
1.99
2.3
2.2
—
—
—
0
0
5
11
4.65
1.95
1.2
1.5
—
—
—
0
0
38
250
1.68
1.95
1.4
1.4
2.7
2.6
g/l
0.04
23
161
38
253
1.66
1.86
3.8
3.0
2.5
2.5
mmol/l
0.13
30
222
29
438
0.59
1.82
3.8
3.3
—
—
—
0
0
41
281
1.62
1.79
1.4
1.8
1.5
1.6
mg/l
0.04
30
225
24
143
1.80
1.73
2.9
1.7
—
—
—
0
0
13
62
2.19
1.71
1.2
1.3
—
—
—
0
0
14
69
2.13
1.70
1.1
1.2
—
—
—
0
0
8
32
2.58
1.62
1.1
1.1
—
—
—
0
0
44
315
1.55
1.60
1.3
1.3
—
—
—
0
0
6
20
3.08
1.59
1.3
1.5
—
—
—
0
0
38
265
1.57
1.54
1.4
1.2
0.6
1.7
u/ml
—
8
87
79
647
1.44
1.45
4.7
4.3
0.0
0.0
estimate
0.00
14
123
5
16
3.19
1.45
6.4
4.8
—
—
—
0
0
18
104
1.82
1.44
1.6
1.5
—
—
—
0
0
78
639
1.43
1.42
5.5
5.8
0.0
0.0
estimate
0.00
15
134
66
525
1.44
1.41
2.2
2.2
—
—
—
0
0
55
427
1.44
1.33
3.7
4.4
—
—
—
0
0
77
638
1.40
1.28
4.6
4.3
0.0
0.0
estimate
0.00
14
132
21
135
1.64
1.19
1.3
1.6
—
—
—
0
0
69
573
1.36
1.09
3.7
4.2
194.0
41.4
ng/l
0.46
52
415
38
285
1.44
1.09
4.4
4.0
—
—
—
0
0
23
156
1.55
1.06
1.3
1.3
—
—
—
0
0
16
99
1.68
1.04
1.1
2.2
—
—
—
0
0
5
22
2.31
1.04
1.0
1.1
—
—
—
0
0
0
29
0.00
0.99
0.0
1.1
—
1.9
—
0
21
0
29
0.00
0.99
0.0
1.3
—
7.9
—
0
22
0
32
0.00
0.96
0.0
1.3
—
—
—
0
0
12
70
1.77
0.95
5.6
8.4
—
—
—
0
0
26
187
1.47
0.93
2.5
2.0
—
—
—
0
0
22
153
1.51
0.92
1.5
1.4
—
—
—
0
0
28
206
1.44
0.89
1.4
1.3
1.2
9.5
u/ml
—
8
79
17
112
1.58
0.89
2.5
3.2
4.3
4.2
kpa
0.07
17
107
25
180
1.46
0.89
18.1
21.1
1.4
1.4
inr
—
7
21
13
81
1.66
0.84
1.4
1.2
—
—
—
0
0
6
32
1.91
0.82
1.2
5.7
—
—
—
0
0
6
33
1.85
0.80
1.7
1.5
—
—
—
0
0
0
24
0.00
0.80
0.0
1.2
—
—
—
0
0
0
27
0.00
0.78
0.0
3.5
—
43.0
—
0
27
35
275
1.35
0.77
5.4
6.6
—
—
—
0
0
19
134
1.47
0.75
2.7
3.7
—
—
—
0
0
5
25
2.03
0.73
1.2
2.4
—
—
—
0
0
11
69
1.64
0.70
1.2
1.2
—
—
—
0
0
28
216
1.36
0.69
1.7
1.9
29.1
29.4
s
0.10
28
210
7
42
1.70
0.69
1.6
1.6
0.2
0.2
g/l
—
7
42
17
120
1.47
0.68
2.0
1.5
—
—
—
0
0
5
28
1.81
0.66
4.6
2.3
—
—
—
0
0
16
112
1.48
0.66
4.7
8.5
—
—
—
0
0
124
1165
1.29
0.63
6.9
4.7
1.8
2.0
mu/l
0.46
116
1032
36
294
1.29
0.62
2.7
2.6
4.6
4.3
e6/l
0.09
29
259
100
918
1.24
0.61
4.3
4.0
—
—
—
0
0
66
581
1.23
0.60
11.7
10.8
0.0
0.0
e9/l
0.01
56
482
117
1239
0.79
0.59
5.4
4.7
1.4
1.5
mmol/l
1.04
106
1121
113
1201
0.80
0.59
4.7
4.3
1.3
1.3
mmol/l
0.11
100
1082
12
81
1.52
0.59
1.1
1.5
—
—
—
0
0
10
65
1.57
0.57
1.2
1.2
71.4
116.1
u/ml
—
10
59
12
83
1.48
0.53
3.8
3.9
—
—
—
0
0
6
40
1.52
0.52
1.0
1.2
—
—
—
0
0
56
492
1.21
0.51
5.6
3.8
421.4
83.6
e6/l
0.40
41
362
7
45
1.58
0.49
1.6
1.6
1.2
1.2
g/l
—
7
45
119
1250
0.81
0.49
5.4
4.8
4.2
4.6
mmol/l
3.36
108
1137
43
369
1.23
0.49
4.0
3.1
—
—
—
0
0
122
1277
0.81
0.47
6.1
5.3
2.4
2.7
mmol/l
3.12
111
1155
132
1263
1.26
0.47
22.6
15.4
27.0
23.4
mg/l
0.61
118
1007
41
352
1.22
0.47
5.8
4.5
0.0
0.0
estimate
0.00
14
132
10
69
1.48
0.45
1.4
2.9
1.1
1.3
%
—
10
69
0
15
0.00
0.41
0.0
3.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
20
160
1.29
0.41
4.9
6.8
-0.3
1.0
mmol/l
0.73
13
127
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
5
35
1.44
0.39
1.4
1.6
—
—
—
0
0
48
426
1.18
0.39
4.6
3.2
677.0
191.3
e6/l
0.34
38
338
5
36
1.40
0.38
1.0
2.4
9.5
11.9
mg/l
—
5
36
11
81
1.38
0.37
4.6
6.5
25.0
24.7
mmol/l
0.10
11
81
42
370
1.18
0.37
4.0
4.1
—
—
—
0
0
6
47
1.29
0.32
1.0
1.1
—
—
—
0
0
7
52
1.36
0.31
5.1
1.9
—
—
—
0
0
32
281
1.17
0.29
2.7
3.1
527.3
553.1
mosm/kgh2o
0.40
25
243
13
104
1.27
0.27
1.5
1.4
—
—
—
0
0
30
265
1.16
0.26
5.5
4.5
1.0
1.0
kg/l
—
7
42
9
76
1.20
0.25
1.2
1.4
—
—
—
0
0
43
392
1.13
0.24
4.0
3.1
2.5
0.5
e6/l
0.92
32
300
136
1328
1.16
0.23
26.3
17.7
139.2
139.8
mmol/l
1.78
136
1288
13
107
1.23
0.22
3.8
3.9
—
—
—
0
0
15
126
1.21
0.22
2.3
4.0
1.2
1.2
mmol/l
0.55
15
110
0
11
0.00
0.21
0.0
1.0
—
290.8
—
0
6
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
0.9
—
0
12
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
14
118
1.20
0.20
3.9
4.3
—
—
—
0
0
124
1208
1.12
0.19
9.1
6.3
43.9
40.8
mmol/mol
2.04
117
1114
136
1333
1.14
0.18
26.4
17.7
3.9
4.0
mmol/l
2.08
136
1292
136
1385
0.88
0.18
35.5
22.6
128.9
134.6
g/l
4.11
136
1359
136
1384
0.88
0.16
35.1
22.4
29.7
30.4
pg
3.18
136
1360
11
92
1.21
0.16
4.7
2.7
—
—
—
0
0
136
1335
1.12
0.16
27.1
18.4
79.5
79.8
umol/l
0.03
136
1335
136
1383
0.89
0.15
35.1
22.4
90.2
91.4
fl
2.33
136
1359
9
80
1.13
0.15
5.2
9.1
24.1
24.4
mmol/l
—
9
72
130
1322
0.91
0.13
21.0
14.1
—
—
—
0
0
127
1248
1.09
0.12
6.5
4.9
6.5
6.1
mmol/l
2.01
121
1129
111
1087
1.07
0.11
24.4
16.0
37.6
39.6
%
0.92
74
737
6
53
1.14
0.09
1.0
2.4
—
—
—
0
0
46
479
0.94
0.08
4.5
5.1
6.4
3.1
ug/l
0.42
40
419
5
63
0.79
0.08
2.4
3.1
4.4
4.3
pmol/l
—
5
55
31
294
1.07
0.08
2.3
3.2
0.9
0.8
ug/l
0.14
21
192
32
333
0.95
0.05
5.5
7.2
—
—
—
0
0
10
95
1.06
0.00
5.8
9.0
94.0
93.9
%
—
10
95
102
1019
1.00
0.00
31.4
19.7
328.5
331.7
g/l
1.98
102
1013
0
7
0.00
0.00
0.0
8.9
—
963.6
—
0
7
0
7
0.00
0.00
0.0
12.0
—
1635.6
—
0
7
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
2400.0
—
0
6
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
1.7
—
0
9
5
53
0.94
0.00
20.4
11.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
1.1
—
0
5
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
8
80
1.00
0.00
4.0
4.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
7
71
0.99
0.00
1.4
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_STOMACH_NEUROENDOCRINE – Neuroendocrine tumor and carcinoma of stomach

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).