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Neuroendocrine tumor and carcinoma of stomach

C3_STOMACH_NEUROENDOCRINE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C16
  • Cancer registry: Morphology ICD-O-3 8240|824[2-4]|8246|8249
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

160

4. Check minimum number of events

None

160

5. Include endpoints

None

160

6. Filter based on genotype QC (FinnGen only)

160

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Neuroendocrine tumor and carcinoma of stomach based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 160 84 76
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 62.11 59.36 65.16

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
149
Matched controls
1491
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K29.4
ICD-10 Finland
Chronic atrophic gastritis
132.6
85.0
86
15
8240/3-C16.9
ICD-O-3
Neuroendocrine tumor, NOS, of stomach, NOS
+∞
78.1
68
*
B03BA03
ATC
hydroxocobalamin; parenteral
49.2
77.1
97
54
107
Kela drug reimbursment
Pernicious anaemia
94.3
63.9
68
13
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
18.3
51.3
124
317
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
69.8
51.0
57
13
B81
ICPC
Anaemia vit B12/folate deficiency
33.9
49.0
65
33
8240/3-C16.2
ICD-O-3
Neuroendocrine tumor, NOS, of body of stomach
+∞
46.3
42
*
D37.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Stomach
135.2
38.9
40
*
JDA05
NOMESCO Finland
Endoscopic polypectomy in stomach or pylorus
+∞
26.9
25
*
UJD02
NOMESCO Finland
Gastroscopy
9.1
13.2
28
37
C16.9
ICD-10 Finland
Malignant neoplasm: Stomach, unspecified
55.1
13.1
15
*
E34.0
ICD-10 Finland
Carcinoid syndrome
55.1
13.1
15
*
A50
ICPC
General and Unspecified, Medication/prescr/renewal
10.9
11.2
21
22
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
35.3
10.5
13
*
JDA45
NOMESCO Finland
Endoscopic mucosal or submucosal resection in stomach or pylorus
106.4
9.5
10
*
JN5ER
NOMESCO Finland
PET-CT of receptors in whole body
23.5
9.5
13
6
8240/3-C16.0
ICD-O-3
Neuroendocrine tumor, NOS, of cardia, NOS
+∞
9.5
9
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.2
8.0
25
56
UJF32
NOMESCO Finland
Coloscopy
2.8
7.5
59
280
S50
ICPC
Skin, Medication/prescr/renewal
84.0
7.5
8
*
130
Kela drug reimbursment
Malignant tumour
4.3
6.9
25
66
H01CB02
ATC
octreotide; parenteral
42.0
6.8
8
*
A55
ICPC
General and Unspecified, Local injection/infiltration
23.8
6.8
9
*
K31.7
ICD-10 Finland
Polyp of stomach and duodenum
28.0
6.3
8
*
8249/3-C16.2
ICD-O-3
Neuroendocrine tumor, grade 2 of body of stomach
+∞
6.3
6
*
8249/3-C16.9
ICD-O-3
Neuroendocrine tumor, grade 2 of stomach, NOS
+∞
6.3
6
*
JDA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in stomach or pylorus
+∞
6.3
6
*
D13.3
ICD-10 Finland
Benign neoplasm: Other and unspecified parts of small intestine
+∞
6.3
6
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
6.9
6.0
14
22

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_STOMACH_NEUROENDOCRINE – Neuroendocrine tumor and carcinoma of stomach

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).