Benign neoplasm: Uterine tubes and ligaments

CD2_BENIGN_UTERINE_TUBES_LIGAMENTS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D28.7&
  • Hospital discharge: ICD-9 2210
  • Hospital discharge: ICD-8 2210
  • Cause of death: ICD-10 D28.7&
  • Cause of death: ICD-9 2210
  • Cause of death: ICD-8 2210

2 out of 7 registries used, show all original rules.

222

4. Check minimum number of events

None

222

5. Include endpoints

None

222

6. Filter based on genotype QC (FinnGen only)

222

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D28
Name in latin
Neoplasma benignum alterius organi genitalis feminini specificati

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1728 1728 -
Only index persons 1555 1555 -
Unadjusted period prevalence (%)
Whole population 0.05 0.05 -
Only index persons 0.06 0.06 -
Median age at first event (years)
Whole population - 39.39 -
Only index persons - 37.97 -

-FinnGen-

Key figures

All Female Male
Number of individuals 222 222 -
Unadjusted period prevalence (%) 0.08 0.08 -
Median age at first event (years) 36.36 36.36 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
201
Matched controls
2010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
22101
ICD-8 Finland
Benign neoplasm of other female genital organs, Fallopian tube and broad ligament
+∞
118.9
102
*
2210A
ICD-9 Finland
Benign neoplasm of other female genital organs, Fallopian tube and uterine ligaments
+∞
60.5
55
*
D28.7
ICD-10 Finland
Benign neoplasm: Other specified female genital organs
+∞
38.8
36
*
8204
FHL
Salpingo-oophorectomy
13.1
10.1
17
14
121
Kela drug reimbursment
Severe hypofunction of sexual glands
8.8
7.0
14
17
8206
FHL
Removal of the parovarial cyst
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
15
9.14
10.33
1.8
1.2
—
—
—
0
0
38
183
2.30
4.71
2.6
3.7
—
—
—
0
0
83
603
1.60
2.79
3.8
3.8
—
—
—
0
0
15
63
2.48
2.52
3.5
3.4
—
—
—
0
0
105
851
1.44
1.95
2.1
2.1
—
—
—
0
0
123
1426
0.69
1.94
3.9
3.9
—
—
—
0
0
50
680
0.66
1.83
3.3
3.6
7.4
7.4
ph
—
10
125
41
553
0.68
1.39
3.8
3.1
0.2
0.5
e6/l
1.65
31
409
0
38
0.00
1.35
0.0
2.1
—
—
—
0
0
40
536
0.69
1.31
3.9
3.0
—
—
—
0
0
34
244
1.46
1.17
17.4
19.1
1.5
1.2
inr
—
8
34
212
2038
1.89
1.16
11.1
10.7
24.7
23.3
u/l
0.64
203
1954
163
1492
1.35
1.16
4.6
4.3
12.0
13.5
mm/h
1.03
149
1358
93
792
1.30
1.11
3.5
4.0
—
—
—
0
0
5
21
2.41
1.09
1.4
2.8
—
—
—
0
0
193
1821
1.46
1.09
6.3
5.9
39.5
39.9
mmol/mol
0.30
178
1682
88
748
1.29
1.06
3.9
3.8
27.0
27.4
ng/l
0.01
62
549
72
596
1.31
1.05
2.0
2.3
—
—
—
0
0
16
100
1.65
1.00
1.3
1.3
—
—
—
0
0
201
1918
1.51
0.99
5.1
4.6
4.8
4.8
mmol/l
0.14
186
1760
5
23
2.20
0.98
1.0
1.5
1218.2
164.2
u/ml
—
5
23
7
36
1.97
0.98
2.4
2.3
7.7
7.7
kpa
—
7
31
6
27
2.26
0.94
1.3
1.6
—
—
—
0
0
48
588
0.77
0.87
3.4
3.2
16.5
53.0
e6/l
1.87
41
446
204
1961
1.50
0.86
5.6
5.3
2.8
2.8
mmol/l
0.27
186
1790
61
712
0.80
0.73
4.2
3.8
413.8
90.3
e6/l
0.40
43
491
31
392
0.76
0.71
3.5
4.1
119.5
96.7
ng/l
0.12
23
312
32
250
1.33
0.71
1.2
1.2
—
—
—
0
0
5
27
1.87
0.69
1.6
2.0
—
—
—
0
0
206
1996
1.44
0.68
15.6
16.4
140.1
139.8
mmol/l
0.81
200
1937
12
78
1.57
0.67
2.8
4.2
—
—
—
0
0
106
959
1.20
0.66
4.0
5.0
1.2
1.2
mmol/l
0.48
89
869
147
1373
1.21
0.64
5.1
4.7
—
—
—
0
0
59
506
1.23
0.63
1.5
1.5
24.4
23.2
nmol/l
0.19
43
422
189
1814
1.28
0.62
4.7
4.1
1.3
1.3
mmol/l
0.21
171
1642
71
622
1.21
0.62
6.7
5.3
—
—
—
0
0
206
2001
1.41
0.61
15.7
16.5
3.9
3.9
mmol/l
0.11
201
1937
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
16
115
1.42
0.58
1.2
1.3
—
47.8
—
0
7
121
1118
1.18
0.57
4.2
4.4
6.6
6.6
mmol/l
0.12
111
1034
73
646
1.19
0.57
2.5
2.2
84.3
55.1
u/l
0.67
68
590
16
116
1.41
0.56
3.1
2.4
—
—
—
0
0
213
2087
1.51
0.53
22.1
21.1
4.4
4.4
e12/l
0.83
204
2024
213
2087
1.51
0.53
22.3
21.3
131.9
131.3
g/l
0.32
208
2051
213
2087
1.51
0.53
22.0
21.0
29.9
30.2
pg
1.21
206
2051
213
2086
1.52
0.53
22.0
21.1
90.7
91.3
fl
1.08
206
2050
161
1685
0.84
0.52
14.5
15.5
39.4
39.1
%
0.21
92
1155
109
1004
1.17
0.52
3.9
4.2
0.0
0.0
estimate
0.00
14
187
198
1920
1.29
0.52
5.4
4.8
5.8
5.9
mmol/l
0.99
182
1741
33
272
1.25
0.51
1.4
1.3
146.7
642.8
titre
—
6
71
55
479
1.20
0.51
2.7
2.2
3.0
3.3
mg/l
0.43
49
411
52
451
1.20
0.50
4.7
4.7
1.0
1.0
kg/l
0.47
11
60
13
93
1.42
0.49
2.2
1.9
—
—
—
0
0
25
200
1.28
0.49
1.8
1.5
—
—
—
0
0
193
1982
0.80
0.47
13.8
13.1
—
—
—
0
0
52
589
0.85
0.45
1.7
1.6
1.2
1.3
mmol/l
0.48
43
489
109
1013
1.15
0.45
4.9
5.6
0.0
0.0
estimate
0.00
12
183
196
1905
1.25
0.44
5.3
4.5
1.6
1.6
mmol/l
1.58
180
1741
196
1907
1.24
0.42
14.9
14.1
16.6
20.7
mg/l
1.55
155
1483
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
2.4
—
461.5
—
0
11
0
16
0.00
0.41
0.0
2.9
—
597.1
—
0
11
109
1018
1.14
0.41
3.9
4.2
0.0
0.0
estimate
0.00
14
181
8
60
1.35
0.40
1.4
1.7
87.1
187.1
ug/l
—
8
54
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
42
479
0.85
0.39
1.3
1.3
—
—
—
0
0
37
425
0.84
0.38
2.4
2.7
2.4
2.5
mmol/l
0.14
31
370
5
37
1.36
0.37
1.0
1.2
—
—
—
0
0
212
2086
1.36
0.36
22.3
21.1
257.4
258.4
e9/l
0.09
204
2031
212
2087
1.35
0.34
22.3
21.1
6.4
6.6
e9/l
0.38
202
2023
102
1084
0.89
0.34
4.8
5.5
9.4
9.9
umol/l
0.42
95
1013
70
642
1.13
0.34
3.0
2.0
106.8
141.0
u/l
1.35
65
599
27
230
1.20
0.33
3.7
3.9
6.1
8.2
ug/l
0.25
22
190
17
138
1.25
0.31
1.1
1.2
80.7
158.9
iu/ml
—
5
63
20
166
1.23
0.31
3.2
5.4
1.3
1.4
mmol/l
0.18
20
159
87
814
1.11
0.30
3.2
2.8
100.5
92.5
ug/l
0.27
80
738
71
765
0.89
0.30
2.6
3.0
2.4
2.4
mmol/l
0.06
55
661
189
1846
1.16
0.29
6.5
5.4
14.9
1.9
mu/l
0.49
172
1681
8
109
0.72
0.29
20.8
2.9
5.8
4.4
pmol/l
—
8
90
17
205
0.82
0.29
1.4
1.5
—
—
—
0
0
7
57
1.24
0.29
4.6
3.3
—
—
—
0
0
7
57
1.24
0.29
1.0
1.1
—
—
—
0
0
57
621
0.89
0.29
3.4
3.2
—
—
—
0
0
17
140
1.23
0.28
3.6
2.7
—
—
—
0
0
18
150
1.22
0.27
3.8
4.2
0.1
0.2
%
—
7
43
10
77
1.31
0.26
1.1
1.3
—
1.5
—
0
7
9
74
1.23
0.25
1.6
1.8
—
—
—
0
0
96
910
1.10
0.25
7.4
5.6
30.7
28.4
%
1.43
89
837
10
78
1.30
0.24
1.6
1.3
—
—
—
0
0
6
83
0.72
0.24
1.2
1.5
—
—
—
0
0
34
378
0.88
0.24
1.9
2.8
480.5
503.9
mosm/kgh2o
0.27
28
323
205
2020
1.19
0.24
17.2
16.9
70.9
70.8
umol/l
0.04
205
2020
101
964
1.09
0.22
7.2
5.2
0.0
0.0
e9/l
0.31
89
833
18
209
0.85
0.22
2.1
2.2
4.1
7.4
umol/l
2.07
18
183
91
865
1.09
0.22
7.5
5.5
0.8
0.7
%
0.97
83
794
104
995
1.09
0.21
7.3
5.5
0.2
0.2
e9/l
0.80
91
876
15
126
1.20
0.21
2.8
2.5
3.1
4.3
e9/l
2.73
15
96
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
146.4
—
0
11
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
4.3
—
43.8
—
0
10
14
166
0.83
0.21
2.9
4.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
1.1
—
0
13
48
444
1.10
0.20
1.8
1.7
379.0
21098749.8
pmol/l
0.50
40
346
100
957
1.08
0.20
7.2
5.2
0.5
0.6
e9/l
0.40
87
829
9
115
0.77
0.20
3.3
3.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
2.0
—
0
14
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
50
1.21
0.20
1.2
1.2
386.3
474.1
mg/l
—
6
45
12
143
0.83
0.19
1.2
1.1
—
—
—
0
0
94
900
1.08
0.18
7.6
5.7
8.3
8.4
%
0.08
87
835
12
100
1.21
0.18
3.8
5.5
27.0
25.4
mmol/l
0.40
12
100
7
58
1.21
0.18
2.1
2.5
—
—
—
0
0
58
545
1.09
0.18
4.2
4.7
0.1
0.0
estimate
0.47
14
191
7
61
1.15
0.17
6.9
9.2
—
—
—
0
0
75
787
0.93
0.17
7.0
8.0
1.2
1.2
inr
0.03
16
234
44
409
1.09
0.17
1.6
1.7
1257.1
1273.2
nmol/l
0.03
32
301
52
488
1.09
0.17
4.6
4.1
—
—
—
0
0
18
158
1.15
0.17
1.3
1.5
—
—
—
0
0
102
983
1.07
0.16
7.3
5.2
2.2
2.0
e9/l
0.31
90
865
26
235
1.12
0.16
4.3
5.2
102.9
103.3
mmol/l
0.20
26
227
70
735
0.93
0.16
4.0
3.2
—
—
—
0
0
6
77
0.77
0.16
1.7
1.5
—
—
—
0
0
6
79
0.75
0.16
1.5
1.2
—
—
—
0
0
16
140
1.15
0.15
3.4
4.1
0.3
0.8
%
—
6
31
89
856
1.07
0.15
2.0
2.0
105.9
100.6
pmol/l
0.34
40
368
57
600
0.93
0.14
3.1
2.9
6.2
6.4
mmol/l
0.18
52
489
8
95
0.84
0.14
5.4
7.3
26.6
24.9
mmol/l
—
8
89
23
252
0.90
0.13
1.5
1.3
—
—
—
0
0
18
161
1.13
0.13
3.8
4.1
0.6
0.9
%
—
7
48
9
109
0.82
0.13
1.6
1.3
—
—
—
0
0
42
446
0.93
0.13
1.5
1.7
1.0
1.1
mg/l
0.03
27
352
17
152
1.13
0.12
1.1
1.3
—
—
—
0
0
37
394
0.93
0.12
1.3
1.3
39.9
37.3
iu/ml
0.06
12
145
93
901
1.06
0.12
7.6
5.3
55.6
56.9
%
0.57
86
837
19
172
1.11
0.12
1.2
3.2
16.7
58.5
u/ml
1.11
19
166
17
153
1.12
0.11
3.0
6.3
—
—
—
0
0
15
167
0.89
0.11
1.5
1.3
—
—
—
0
0
50
524
0.94
0.11
7.7
6.8
—
—
—
0
0
43
453
0.94
0.11
1.4
1.3
0.5
2.4
u/ml
—
8
123
23
249
0.91
0.11
1.5
1.2
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
3.4
4.1
mmol/l
—
5
38
5
44
1.14
0.10
1.2
2.0
—
—
—
0
0
5
45
1.11
0.10
1.0
2.2
—
—
—
0
0
16
145
1.11
0.09
4.1
4.2
0.2
0.2
%
—
6
34
92
896
1.05
0.09
7.5
5.4
2.9
2.7
%
0.31
85
827
18
196
0.91
0.09
1.5
1.4
—
—
—
0
0
25
267
0.93
0.09
1.8
2.0
—
—
—
0
0
6
57
1.05
0.08
1.0
1.2
—
—
—
0
0
6
58
1.04
0.08
3.3
2.0
—
—
—
0
0
107
1049
1.04
0.07
4.3
5.7
1.2
1.2
mmol/l
0.75
88
891
40
417
0.95
0.07
2.5
2.5
4.4
5.9
e6/l
0.65
32
371
116
1142
1.03
0.06
8.8
8.5
3.9
4.0
e9/l
0.04
100
1010
52
535
0.96
0.05
2.8
3.9
—
—
—
0
0
29
303
0.95
0.05
1.5
1.2
—
—
—
0
0
85
866
0.97
0.05
8.9
9.2
0.0
0.0
e9/l
1.06
71
714
45
436
1.04
0.05
3.9
4.3
—
—
—
0
0
48
494
0.96
0.05
2.0
2.5
331.5
9503.5
umol/l
3.44
39
416
20
189
1.06
0.05
1.4
1.7
—
—
—
0
0
19
201
0.94
0.04
1.4
1.4
—
—
—
0
0
38
392
0.96
0.04
1.9
1.5
2.5
2.5
g/l
0.05
24
225
15
142
1.06
0.02
1.3
2.6
—
—
—
0
0
11
103
1.07
0.02
1.2
1.3
—
—
—
0
0
61
618
0.98
0.01
3.7
3.8
2.2
5.8
mg/mmol
1.47
31
346
13
124
1.05
0.00
4.5
4.7
—
—
—
0
0
12
126
0.95
0.00
1.2
1.3
—
—
—
0
0
58
586
0.99
0.00
3.0
3.1
14.2
255.0
mg/l
0.87
32
341
18
176
1.02
0.00
4.7
3.4
—
—
—
0
0
12
119
1.01
0.00
1.1
1.3
—
—
—
0
0
23
234
0.98
0.00
2.1
1.9
173.3
129.0
ug/g
0.37
17
183
154
1539
1.00
0.00
7.1
7.0
76.4
79.8
u/l
0.45
142
1425
11
107
1.03
0.00
1.5
2.0
1.1
1.1
%
0.16
11
107
16
156
1.03
0.00
1.7
1.5
—
—
—
0
0
38
382
0.99
0.00
1.3
1.3
17.2
12.4
u/ml
0.11
19
140
49
488
1.01
0.00
3.9
3.7
—
—
—
0
0
22
218
1.01
0.00
4.7
6.4
2.4
1.7
mmol/l
0.21
16
178
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
30.9
—
92.9
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
161
1610
1.00
0.00
5.7
4.5
14.8
14.9
pmol/l
0.42
144
1458
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
8.4
—
0.7
—
0
5
0
5
0.00
0.00
0.0
1.0
—
3.7
—
0
5
5
52
0.96
0.00
1.0
5.5
—
—
—
0
0
5
58
0.86
0.00
2.0
5.0
—
—
—
0
0
19
190
1.00
0.00
1.6
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
226.1
—
0
5
0
5
0.00
0.00
0.0
1.0
—
4.9
—
0
5
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
125.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_UTERINE_TUBES_LIGAMENTS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_UTERINE_TUBES_LIGAMENTS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_UTERINE_TUBES_LIGAMENTS – Benign neoplasm: Uterine tubes and ligaments

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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