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Benign neoplasm: Eye, unspecified

CD2_EYE_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D31.9&
  • Hospital discharge: ICD-9 224[8-9]|2240
  • Hospital discharge: ICD-8 22409|22402
  • Cause of death: ICD-10 D31.9&
  • Cause of death: ICD-9 224[8-9]|2240
  • Cause of death: ICD-8 22409|22402

2 out of 7 registries used, show all original rules.

154

4. Check minimum number of events

None

154

5. Include endpoints

None

154

6. Filter based on genotype QC (FinnGen only)

154

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D31
Name in latin
Neoplasma benignum oculi non specificatum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 154 100 54
Unadjusted period prevalence (%) 0.03 0.03 0.02
Median age at first event (years) 57.05 55.43 60.05

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
141
Matched controls
1411
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D31.9
ICD-10 Finland
Benign neoplasm: Eye, unspecified
+∞
138.2
109
*
CBB30
NOMESCO Finland
Excision of lesion of eyelid
13.5
11.8
20
17
2240A
ICD-9 Finland
Benign neoplasm of eye, Eyeball, except conjunctiva, cornea, retina and choroid
+∞
10.5
10
*
CBB99
NOMESCO Finland
Other excision or destruction of lesion of eyelid
59.1
9.8
11
*
2248X
ICD-9 Finland
Benign neoplasm of eye, Other specified parts of eye
+∞
8.4
8
*
3401
FHL
Removal of local modification or taking a specimen in the operating room
+∞
7.3
7
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.3
6.9
38
143
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
73.0
6.5
7
*
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
+∞
6.3
6
*
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
8.3
6.3
13
17

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
157
2.40
4.34
1.4
1.4
980.0
535.1
titre
—
8
45
7
10
7.27
3.40
1.3
2.5
—
—
—
0
0
61
414
1.78
2.95
11.2
5.7
—
—
—
0
0
7
14
5.18
2.76
1.3
1.1
—
—
—
0
0
76
575
1.64
2.34
14.9
10.5
0.0
0.0
e9/l
0.52
65
471
76
585
1.59
2.12
9.0
5.8
2.9
2.7
%
0.31
71
543
29
176
1.80
1.98
3.6
2.7
26.0
23.1
%
0.26
24
152
7
22
3.28
1.90
5.3
2.7
—
—
—
0
0
5
12
4.27
1.83
1.2
1.3
—
—
—
0
0
16
81
2.09
1.82
2.8
1.9
1.4
1.8
g/l
0.21
16
74
8
29
2.85
1.82
1.8
1.7
—
—
—
0
0
18
96
1.99
1.79
5.8
3.1
12.0
10.3
g/l
0.55
18
89
22
127
1.85
1.75
1.7
1.4
—
—
—
0
0
25
151
1.78
1.73
3.5
3.1
1.9
1.8
%
0.16
20
139
80
643
1.51
1.73
8.2
5.7
1.7
1.9
e9/l
0.82
74
575
15
76
2.08
1.71
1.5
1.6
—
—
—
0
0
67
521
1.51
1.69
4.0
4.1
62.4
42.2
ng/l
0.24
38
371
78
633
1.47
1.56
8.2
5.8
0.0
0.0
e9/l
0.25
69
555
5
15
3.41
1.53
2.2
1.7
34.2
31.9
pg
—
5
15
112
980
1.52
1.51
3.7
4.1
15.1
14.9
pmol/l
0.32
98
879
9
39
2.39
1.45
1.1
1.4
0.2
0.2
g/l
—
9
39
45
331
1.51
1.45
1.6
1.5
18.2
21.6
nmol/l
0.91
34
271
9
40
2.33
1.43
1.2
1.4
1.2
1.1
g/l
—
9
40
11
53
2.16
1.42
1.4
1.3
—
—
—
0
0
21
131
1.70
1.32
2.2
1.6
—
—
—
0
0
5
18
2.83
1.29
2.0
1.8
92.0
90.3
%
—
5
18
5
18
2.83
1.29
1.8
1.9
—
—
—
0
0
25
165
1.61
1.28
1.5
1.5
—
—
—
0
0
76
631
1.40
1.26
8.4
5.7
0.6
0.6
e9/l
0.40
68
554
88
751
1.40
1.24
16.2
9.9
3.4
4.0
e9/l
2.99
82
660
50
389
1.42
1.19
3.0
2.9
6.3
7.6
mmol/l
1.40
42
322
78
656
1.38
1.18
10.9
6.2
0.2
0.2
e9/l
0.26
71
582
56
446
1.40
1.17
6.1
3.5
2.3
2.4
mmol/l
1.32
48
394
5
20
2.55
1.16
1.8
1.3
—
—
—
0
0
5
20
2.55
1.16
1.2
1.2
—
—
—
0
0
16
96
1.74
1.15
2.4
1.7
—
—
—
0
0
7
30
2.40
1.14
2.0
1.6
—
—
—
0
0
5
23
2.21
0.99
2.2
1.8
253.8
258.3
u/ml
—
5
15
14
86
1.69
0.94
2.1
2.4
4.2
4.1
e9/l
—
9
67
133
1245
1.50
0.93
4.5
4.7
5.9
6.0
mmol/l
0.05
120
1131
6
28
2.19
0.92
1.0
1.1
—
—
—
0
0
15
95
1.64
0.91
4.3
4.9
0.0
0.3
%
—
5
26
6
29
2.11
0.90
1.0
1.1
—
—
—
0
0
8
42
1.95
0.90
1.3
1.0
—
—
—
0
0
24
171
1.48
0.90
1.1
1.2
—
—
—
0
0
46
369
1.35
0.90
3.2
2.9
1566.9
229.5
mg/l
0.40
27
236
23
163
1.48
0.88
2.1
1.7
—
—
—
0
0
6
30
2.04
0.88
1.0
1.2
—
—
—
0
0
6
30
2.04
0.88
1.0
1.1
—
—
—
0
0
6
30
2.04
0.88
4.7
7.2
—
—
—
0
0
6
30
2.04
0.88
1.0
1.1
—
—
—
0
0
8
45
1.82
0.85
1.1
1.2
—
—
—
0
0
35
271
1.38
0.85
3.6
3.0
570.7
533.3
mosm/kgh2o
0.39
28
241
31
235
1.40
0.85
4.3
3.6
629.6
96.0
ng/l
0.50
25
181
48
391
1.33
0.84
4.1
3.7
2.0
8.8
mg/mmol
2.93
31
242
36
283
1.36
0.80
2.8
2.3
1.1
1.0
mg/l
0.13
28
225
61
518
1.29
0.79
2.6
2.1
—
—
—
0
0
14
91
1.59
0.78
3.5
5.5
440.0
294.2
ng/l
0.32
14
79
15
100
1.55
0.76
1.1
1.1
—
—
—
0
0
5
24
2.12
0.75
1.0
1.1
—
—
—
0
0
7
39
1.83
0.73
1.9
1.6
—
—
—
0
0
5
25
2.03
0.73
16.4
5.1
28.8
35.5
umol/l
—
5
19
62
533
1.27
0.72
2.3
2.0
89.2
95.2
pmol/l
0.42
33
273
15
103
1.51
0.68
4.3
4.6
1.0
1.2
%
—
5
30
140
1341
1.48
0.67
22.1
17.1
84.0
76.5
umol/l
1.24
140
1341
25
191
1.37
0.66
2.5
1.8
—
—
—
0
0
69
607
1.25
0.65
9.3
5.6
1.2
1.2
mmol/l
0.50
61
549
17
122
1.44
0.63
11.5
4.0
1.9
2.4
mmol/l
0.28
11
95
8
49
1.67
0.63
5.5
4.0
1.0
0.8
%
—
8
49
58
502
1.25
0.63
9.6
7.9
1.2
1.2
inr
0.33
18
146
17
123
1.43
0.61
11.5
4.0
—
—
—
0
0
0
20
0.00
0.61
0.0
1.9
—
—
—
0
0
0
20
0.00
0.61
0.0
1.3
—
—
—
0
0
121
1139
1.29
0.60
25.0
15.3
38.2
39.6
%
0.86
86
827
105
974
1.25
0.59
5.2
4.1
16.3
12.8
mm/h
1.18
99
883
32
260
1.29
0.57
1.9
1.4
2.2
2.6
g/l
0.22
21
160
17
125
1.40
0.56
3.5
4.4
—
—
—
0
0
14
99
1.46
0.56
3.6
2.7
—
—
—
0
0
125
1190
1.27
0.50
4.7
4.8
1.8
1.9
mu/l
0.87
115
1075
30
360
0.79
0.49
1.7
1.6
1.2
1.4
mmol/l
0.75
21
300
37
314
1.23
0.47
7.8
4.1
90.8
92.2
%
0.11
37
309
31
368
0.80
0.47
4.6
3.9
0.0
0.0
estimate
0.00
15
130
42
362
1.22
0.46
5.5
4.0
—
—
—
0
0
13
96
1.39
0.43
15.2
5.6
—
—
—
0
0
47
413
1.20
0.43
3.5
2.3
—
—
—
0
0
5
32
1.58
0.42
4.8
2.8
—
—
—
0
0
19
151
1.29
0.41
1.2
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
3.3
—
3.4
—
0
19
0
19
0.00
0.39
0.0
2.1
—
—
—
0
0
8
113
0.69
0.39
3.3
3.6
—
—
—
0
0
31
264
1.22
0.39
2.0
1.7
1003.8
1149.7
nmol/l
0.26
20
204
9
69
1.32
0.38
1.4
1.2
—
—
—
0
0
96
904
1.16
0.37
4.1
3.9
—
—
—
0
0
6
44
1.38
0.35
1.5
1.4
4.9
28.9
iu/l
—
6
38
12
153
0.77
0.32
1.8
1.9
—
—
—
0
0
8
108
0.73
0.30
1.5
1.5
—
—
—
0
0
23
196
1.20
0.29
3.2
3.0
0.8
0.7
ug/l
0.22
16
136
12
94
1.30
0.29
6.1
7.3
4.9
5.0
kpa
0.16
12
84
38
340
1.16
0.28
18.2
8.3
—
—
—
0
0
144
1412
1.31
0.28
30.5
21.5
30.3
30.3
pg
0.19
144
1388
144
1412
1.31
0.28
30.6
21.5
91.2
91.3
fl
0.07
144
1388
144
1412
1.31
0.28
30.6
21.6
4.4
4.4
e12/l
0.79
144
1369
8
66
1.22
0.27
7.4
8.9
—
—
—
0
0
8
67
1.20
0.27
4.3
3.8
23.6
24.9
mmol/l
—
8
67
144
1413
1.29
0.26
31.1
21.6
130.8
133.9
g/l
1.66
144
1387
144
1413
1.29
0.26
30.6
21.6
6.4
6.6
e9/l
0.75
144
1369
9
77
1.18
0.25
1.8
3.8
4.6
4.4
pmol/l
—
9
68
17
143
1.21
0.24
1.4
1.2
—
—
—
0
0
5
37
1.36
0.24
1.0
1.2
—
—
—
0
0
12
97
1.26
0.23
1.6
1.3
—
—
—
0
0
14
116
1.23
0.23
5.1
3.6
—
—
—
0
0
5
40
1.26
0.22
9.0
11.1
9.2
8.1
kpa
—
5
35
0
10
0.00
0.21
0.0
2.2
—
2.8
—
0
10
0
10
0.00
0.21
0.0
1.1
—
20.4
—
0
10
0
13
0.00
0.21
0.0
1.1
—
2.1
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
32
290
1.13
0.20
2.5
2.5
5.1
4.8
e6/l
0.07
25
261
37
340
1.12
0.19
3.5
3.0
356.8
7144.5
umol/l
1.73
31
288
7
58
1.22
0.18
1.0
2.1
—
—
—
0
0
7
62
1.14
0.17
6.0
2.4
0.6
0.7
%
—
7
62
40
371
1.11
0.17
3.3
2.8
—
—
—
0
0
5
67
0.74
0.17
1.8
2.5
—
—
—
0
0
12
141
0.84
0.17
9.0
4.4
0.6
0.9
mmol/l
—
7
109
19
213
0.88
0.16
1.2
1.3
53.4
8.3
u/ml
—
6
73
36
384
0.92
0.13
3.5
3.0
0.2
0.5
e6/l
0.61
26
290
44
416
1.08
0.13
5.6
4.1
7.4
7.4
ph
—
9
81
132
1339
0.90
0.12
19.9
13.7
—
—
—
0
0
10
86
1.17
0.11
5.8
2.7
—
—
—
0
0
45
429
1.07
0.10
3.5
3.1
—
—
—
0
0
5
44
1.14
0.10
10.2
5.4
—
—
—
0
0
5
47
1.07
0.09
1.8
1.2
—
—
—
0
0
68
659
1.06
0.09
6.1
5.3
0.0
0.0
estimate
0.00
16
137
41
391
1.07
0.09
4.9
4.1
—
—
—
0
0
6
55
1.09
0.09
1.8
3.2
15.7
2557.9
u/ml
—
6
47
39
372
1.06
0.08
4.7
3.5
—
—
—
0
0
7
65
1.08
0.08
6.1
2.4
1.1
1.2
%
—
7
65
80
781
1.05
0.08
6.5
4.0
6.8
6.5
mmol/l
0.52
75
726
8
75
1.07
0.07
7.1
4.1
—
—
—
0
0
9
87
1.04
0.07
1.4
1.2
—
—
—
0
0
92
905
1.04
0.05
6.0
4.5
—
—
—
0
0
121
1197
1.05
0.05
6.4
5.7
40.3
39.9
mmol/mol
0.14
111
1114
128
1291
0.95
0.04
20.9
14.6
20.4
24.1
mg/l
0.60
105
1033
22
230
0.95
0.03
1.1
1.2
18.8
32.3
iu/ml
0.94
12
77
44
430
1.03
0.03
3.6
2.9
—
—
—
0
0
48
490
0.97
0.03
3.7
3.7
7.6
63.3
e6/l
3.73
33
351
125
1241
1.04
0.02
4.8
4.6
4.8
4.7
mmol/l
0.54
114
1147
121
1202
1.03
0.02
4.3
4.0
1.3
1.3
mmol/l
0.19
107
1097
67
662
1.02
0.01
4.2
3.8
0.0
0.0
estimate
0.00
16
135
19
197
0.96
0.01
2.3
2.0
—
—
—
0
0
29
283
1.03
0.01
1.2
1.2
7.2
1.3
u/ml
—
8
79
13
136
0.95
0.00
1.5
1.7
—
—
—
0
0
123
1236
0.98
0.00
4.8
4.5
1.5
1.5
mmol/l
0.14
109
1130
33
336
0.98
0.00
1.8
1.4
—
—
—
0
0
11
106
1.04
0.00
1.1
1.4
—
—
—
0
0
11
106
1.04
0.00
8.9
3.5
1.3
1.4
mmol/l
0.18
11
101
127
1269
1.00
0.00
5.5
5.1
2.9
2.7
mmol/l
1.02
116
1161
28
281
1.00
0.00
2.1
1.8
414.7
477.3
pmol/l
0.58
23
235
28
283
0.99
0.00
5.2
5.3
—
—
—
0
0
31
305
1.02
0.00
2.8
3.8
—
—
—
0
0
67
665
1.01
0.00
4.3
3.9
0.0
0.0
estimate
0.00
16
126
42
418
1.01
0.00
3.2
3.2
20.6
219.0
e6/l
0.71
31
326
55
549
1.00
0.00
10.0
4.8
34.4
35.5
g/l
0.76
50
517
5
51
0.98
0.00
1.2
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
7
77
0.90
0.00
5.0
3.9
—
—
—
0
0
0
7
0.00
0.00
0.0
9.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
69
1.02
0.00
1.1
1.3
40.1
107.5
u/ml
—
7
60
0
5
0.00
0.00
0.0
2.0
—
183.1
—
0
5
0
5
0.00
0.00
0.0
2.8
—
1.2
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
99
0.90
0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
119.0
—
0
5
0
7
0.00
0.00
0.0
5.1
—
0.7
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_EYE_NOS – Benign neoplasm: Eye, unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).