Dry age-related macular degeneration (includes geographic atrophy), under 50 years

DRY_AMD_EARLY

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Pre-conditions: EVENT_AGE<50 Registry filters: Hospital discharge: ICD-10 — H35.30 Hospital discharge: ICD-9 — 3625A Cause of death: ICD-10 — H35.30 Cause of death: ICD-9 — 3625A 2 out of 7 registries used, show all original rules.	155
4. Check minimum number of events None	155
5. Include endpoints None	155
6. Filter based on genotype QC (FinnGen only)	155

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF12
Parent code in ICD-10: H35
Name in latin: Degeneratio maculae senilis atrophica

NAME	DRY_AMD_EARLY
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS	EVENT_AGE<50
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H3530
HD_ICD_9	3625A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H3530
COD_ICD_9	3625A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Dry age-related macular degeneration (includes geographic atrophy), under 50 years based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	155	87	68
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	46.01	46.03	45.97

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
140: Matched controls
1401

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H35.30

ICD-10 Finland

Kuhnt-Junius degeneration

4033.9

175.0

136

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

30.6

26.4

XCW99

NOMESCO Finland

Other investigative procedure of eye

10.3

20.1

XCK10

NOMESCO Finland

Photography of fundus of eye

10.3

19.8

H35.5

ICD-10 Finland

Hereditary retinal dystrophy

+∞

15.9

Z01.0

ICD-10 Finland

Examination of eyes and vision

5.6

13.7

106

H35.7

ICD-10 Finland

Separation of retinal layers

44.7

13.5

H35.9

ICD-10 Finland

Retinal disorder, unspecified

130.3

11.6

XCD20

NOMESCO Finland

Photoangiography of eye

38.5

11.5

H35.31

ICD-10 Finland

Senile macular degeneration (atrophic)(exudative)

20.8

10.5

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

12.0

10.1

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

7.0

9.1

S01EC01

ATC

acetazolamide; systemic

15.4

8.9

CKC10

NOMESCO Finland

Local photocoagulation of retina

29.6

8.6

XCK00

NOMESCO Finland

Perimetry

6.5

8.6

H26.4

ICD-10 Finland

After-cataract

8.9

7.8

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

4.0

7.5

H35.0

ICD-10 Finland

Background retinopathy and retinal vascular changes

+∞

7.3

CJB10

NOMESCO Finland

Laser discission of secondary cataract

8.7

7.3

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

4.6

7.3

S01BC05

ATC

ketorolac; ophthalmic

13.1

6.7

H26.02

ICD-10 Finland

Presenil cataract

8.8

6.5

Z96.1

ICD-10 Finland

Presence of intraocular lens

5.0

6.5

H54.2

ICD-10 Finland

Moderate visual impairment, binocular

73.0

6.5

ZXA10

NOMESCO Finland

Bilateral

3.4

6.4

122

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3027315) Oxygen [Partial pressure] in Blood

5.56

5.61

2.5

4.2

8.70

9.48

kpa

0.54

(3013290) Carbon dioxide [Partial pressure] in Blood

5.56

5.61

2.5

4.2

5.24

5.20

kpa

0.05

(3012516) Albumin [Mass/volume] in Urine

308

2.22

5.01

3.7

3.1

55.39

264.58

mg/l

0.45

199

(40761536) Microorganisms panel - Urine sediment

3.00

4.94

4.6

3.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.23

4.92

4.4

8.1

23.91

25.10

mmol/l

0.47

(3020682) Albumin/Creatinine [Ratio] in Urine

327

2.18

4.87

5.6

3.8

7.89

5.92

mg/mmol

0.21

209

(3009508) Creatinine [Moles/volume] in Urine

340

2.13

4.66

3.7

2.9

7.01

8.45

mmol/l

2.04

298

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.11

4.34

2.0

1.5

—

(3026782) Osmolality of Urine

195

2.26

4.20

2.5

2.4

544.16

564.60

mosm/kgh2o

0.20

167

(3002582) Erythrocytes [#/volume] in Urine

320

2.06

4.14

3.1

2.8

25.01

28.43

e6/l

0.07

241

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

483

1.92

3.81

6.8

5.5

1.22

1.21

mmol/l

0.47

445

(3032080) INR in Blood by Coagulation assay

423

1.92

3.76

8.4

6.0

1.03

1.11

inr

0.86

124

(3029937) Albumin [Presence] in Urine by Test strip

302

1.97

3.57

4.2

3.4

0.00

estimate

0.00

101

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

6.42

3.55

2.3

3.2

—

(3018095) Leukocytes [#/volume] in Urine

387

1.90

3.52

3.7

3.2

39.98

95.66

e6/l

0.33

268

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

383

1.87

3.37

3.3

2.8

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

259

1.98

3.36

2.0

2.9

432.07

682.53

ng/l

0.81

218

(40768797) Stomach Pathology biopsy report

160

2.17

3.35

1.2

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

293

1.92

3.29

3.4

2.7

0.06

0.33

e6/l

2.50

211

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

537

1.81

3.29

8.7

6.9

1.22

1.21

mmol/l

0.47

464

(3000570) Elastase.pancreatic [Mass/mass] in Stool

3.51

3.26

1.2

1.5

365.00

274.26

ug/g

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

231

1.99

3.21

2.8

2.0

2.62

3.04

mg/l

0.75

200

(3022806) Fractional oxyhemoglobin in Capillary blood

6.05

3.05

1.4

2.7

87.86

90.43

—

(3037467) Urinalysis macro (dipstick) panel - Urine

102

800

1.80

3.00

4.9

3.7

—

(3028271) Lactate [Moles/volume] in Capillary blood

5.58

2.90

1.4

2.7

1.61

1.58

mmol/l

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

7.33

2.56

1.4

1.3

1.66

1.70

mmol/l

—

(3019309) Folate [Moles/volume] in Red Blood Cells

158

1.94

2.38

2.4

1.6

1397.85

1300.89

nmol/l

0.22

124

(3015377) Calcium [Moles/volume] in Serum or Plasma

364

1.69

2.37

3.5

4.0

2.36

2.35

mmol/l

0.27

331

(3023368) Bacteria identified in Blood by Culture

272

1.75

2.31

3.3

4.6

—

(3021901) Oxygen saturation in Capillary blood

4.75

2.29

1.3

1.5

—

(36304419) Bacteria [Presence] in Urine

299

1.71

2.26

2.7

2.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

3.46

2.21

1.1

1.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

3.46

2.21

2.5

2.8

52.63

56.88

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

3.46

2.21

2.5

2.6

3.32

4.86

e9/l

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.49

2.19

2.1

1.4

—

(3000991) Gas panel - Venous blood

2.13

2.10

10.4

6.8

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

105

2.04

2.07

8.4

9.3

125.10

124.65

g/l

0.03

(3003327) Ova and parasites identified in Stool by Light microscopy

2.61

2.06

1.3

1.4

—

(3025941) Bacteria identified in Stool by Culture

2.27

2.06

1.3

1.1

—

(3018418) pH of Serum or Plasma

316

1.65

2.02

4.6

3.2

7.39

7.40

0.25

(3021440) Promyelocytes/100 leukocytes in Blood

2.08

1.99

5.3

4.5

0.33

0.15

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

100

2.03

1.95

4.3

2.9

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.27

1.95

11.0

10.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

210

1.73

1.92

2.5

1.7

488.27

448.20

pmol/l

0.17

188

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.28

1.90

1.3

—

(3021788) Differential panel - Synovial fluid

4.27

1.83

2.2

1.6

—

(3016502) Oxygen saturation in Arterial blood

110

1.94

1.83

8.4

8.9

95.68

96.71

0.45

101

(3026008) Bacteria identified in Urine by Culture

265

1.63

1.77

2.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.23

1.77

2.0

1.8

—

(3027801) Oxygen [Partial pressure] in Arterial blood

119

1.88

1.77

8.1

8.7

13.08

13.10

kpa

0.01

111

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

119

1.88

1.77

8.2

8.7

4.75

5.15

kpa

1.09

109

(3035350) Ketones [Presence] in Urine by Test strip

603

1.51

1.75

4.7

3.1

0.00

estimate

0.00

101

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

200

1.69

1.71

4.3

3.8

20.30

860.68

ng/l

1.61

141

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

182

0.46

1.64

1.9

1.8

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

3.65

1.63

4.2

3.0

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

147

1.75

1.59

2.3

2.2

23.62

0.00

124

(3025159) Blasts/100 leukocytes in Blood

1.93

1.59

4.8

4.3

0.00

0.05

—

(3012544) pH of Venous blood

1.91

1.54

4.6

3.3

—

(3013512) EKG study

328

1.52

1.51

3.4

2.9

—

(42870588) Differential panel, method unspecified - Blood

411

1.48

1.47

6.2

5.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

3.19

1.45

1.2

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

3.19

1.45

1.0

1.1

—

(3042936) Bacteria identified in Isolate by Culture

176

1.65

1.44

2.4

2.0

—

(3017181) Myelocytes/100 leukocytes in Blood

105

1.81

1.40

5.3

4.2

1.50

0.82

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

351

1.49

1.40

2.0

1.7

1.64

1.46

mmol/l

0.49

305

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

429

1.44

1.30

4.2

3.0

24.58

33.73

ng/l

0.29

249

(1616796) Gas panel - Central venous blood

2.83

1.29

4.6

3.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

649

1.41

1.28

5.9

6.3

10.21

10.52

umol/l

0.16

625

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

250

1.52

1.28

1.1

1.2

32.18

7.45

u/ml

0.51

101

(3021601) Nitrite [Presence] in Urine by Test strip

601

1.41

1.28

6.4

4.3

0.00

estimate

0.00

100

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

268

1.50

1.27

1.5

1.7

0.94

0.82

mg/l

0.12

209

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

487

1.42

1.27

4.9

3.1

—

(3024928) Oxygen saturation in Venous blood

2.45

1.25

2.7

1.9

—

(3045424) Erythrocytes [Presence] in Urine

2.68

1.22

1.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

289

1.47

1.20

1.5

1.3

0.49

1.58

u/ml

1.06

(3007853) Bacteria identified in Skin by Aerobe culture

143

1.63

1.19

2.4

1.6

—

(3037522) Nuclear Ab [Titer] in Serum

202

1.54

1.19

1.3

1.4

2056.00

497.69

titre

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

541

1.38

1.16

3.3

2.6

87.96

110.70

ug/l

1.02

509

(3021960) Folate [Moles/volume] in Serum or Plasma

238

1.49

1.15

1.6

1.5

25.98

22.07

nmol/l

0.47

206

(3002179) Metamyelocytes/100 leukocytes in Blood

1.74

1.15

5.7

4.2

0.80

0.50

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

110

983

1.41

1.12

9.0

7.3

75.92

77.54

u/l

0.18

104

924

(3015736) pH of Urine

477

1.38

1.12

4.2

2.9

—

(3013115) Eosinophils [#/volume] in Blood

670

1.37

1.11

6.4

6.3

0.19

e9/l

0.13

600

(3019198) Lymphocytes [#/volume] in Blood

670

1.37

1.11

6.3

5.7

1.80

1.94

e9/l

0.62

596

(40758558) Short blood count panel - Blood

304

1.43

1.07

5.3

6.9

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.06

1.07

5.0

3.3

44.69

53.68

—

(3001019) Free T4 and TSH panel - Serum or Plasma

109

0.44

1.05

1.8

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

607

1.35

1.03

4.9

3.1

0.00

estimate

0.00

(21494755) Public health laboratory ask at order entry panel

221

0.60

1.03

1.4

—

(3001604) Monocytes [#/volume] in Blood

650

1.33

0.98

6.4

5.7

0.54

0.55

e9/l

0.18

567

(3006315) Basophils [#/volume] in Blood

652

1.32

0.95

6.4

5.8

0.04

e9/l

0.06

567

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

129

0.52

0.93

1.9

1.4

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.19

0.92

1.5

1.3

—

(3044290) Cell count panel - Cerebral spinal fluid

2.19

0.92

1.2

1.1

—

(3021589) Normoblasts [#/volume] in Blood

569

1.31

0.88

12.0

7.7

0.00

e9/l

0.24

461

(3022096) Basophils/100 leukocytes in Blood

589

1.31

0.88

6.8

5.4

0.67

0.74

0.59

553

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

108

982

1.33

0.85

5.5

4.0

14.89

14.57

pmol/l

0.66

915

(3019150) Specific gravity of Urine by Refractometry

262

1.38

0.85

5.0

3.4

1.02

kg/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

363

1.34

0.84

4.9

2.7

—

(40768443) Skin Pathology biopsy report

1.78

0.84

1.3

1.2

—

(36660697) Celiac disease serology panel - Serum

1.59

0.82

1.3

1.1

—

(3019069) Monocytes/100 leukocytes in Blood

613

1.29

0.82

6.7

5.7

8.40

8.41

0.01

583

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.72

0.81

1.9

2.4

5.06

5.04

kpa

0.03

(3002256) Pathology report gross observation

161

0.59

0.80

1.1

1.2

—

(3045414) Leukocytes [Presence] in Urine

1.70

0.80

1.5

1.4

—

(3024980) IgG subclass 4 [Mass/volume] in Serum

0.00

0.80

0.0

1.4

—

0.38

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

416

1.30

0.75

2.2

1.8

85.91

99.12

pmol/l

1.18

215

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

1.95

0.71

1.0

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

142

1361

1.52

0.69

5.8

4.6

2.88

2.94

mmol/l

0.37

132

1297

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

331

0.74

0.66

3.4

3.7

15.53

20.67

—

117

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

136

0.64

1.4

1.8

—

(3044640) Blood type and Crossmatch panel - Blood

372

0.76

0.64

3.2

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

247

1.32

0.63

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.67

0.63

1.4

1.0

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

406

1.26

0.63

4.5

2.6

55.00

56.02

u/l

0.07

383

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

137

1309

1.40

0.63

4.6

3.8

1.43

1.33

mmol/l

0.66

126

1237

(3013707) Erythrocyte sedimentation rate by Westergren method

103

950

1.25

0.62

5.4

3.9

11.77

9.34

mm/h

1.57

894

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

134

1277

1.36

0.61

5.5

4.0

6.12

5.84

mmol/l

1.41

122

1212

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

125

1180

1.31

0.61

6.4

4.5

1.84

1.83

mu/l

0.01

117

1106

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.49

0.61

1.5

1.3

55.85

144.12

iu/ml

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

140

1346

1.41

0.57

5.4

4.3

4.80

4.87

mmol/l

0.33

131

1288

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.65

0.56

1.7

1.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

146

1419

1.50

0.54

19.8

13.2

76.12

73.23

umol/l

0.86

146

1419

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

171

1.33

0.53

3.5

2.4

2.68

1.84

e6/l

0.20

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.52

0.52

2.0

1.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

131

1253

1.29

0.50

15.5

10.3

84.71

86.73

ml/min/173m2

0.56

112

1040

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

152

0.70

0.47

1.5

1.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

139

1343

1.34

0.46

5.4

4.2

1.44

1.47

mmol/l

0.32

130

1277

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

259

1.25

0.45

1.2

1.3

19.17

36.16

iu/ml

0.98

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.40

0.42

2.3

1.6

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.0

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.6

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

3.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.0

—

(40761535) Cells panel - Urine sediment

1.39

0.41

3.3

3.7

—

(44790047)

0.00

0.41

0.0

1.7

—

(44806118)

0.00

0.41

0.0

1.7

—

(44790048)

0.00

0.41

0.0

1.7

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.41

0.0

2.5

—

13.72

—

(44790049)

0.00

0.41

0.0

1.7

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.41

0.0

2.9

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

148

0.72

0.41

1.5

2.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.41

0.0

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.33

0.40

2.8

2.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.40

0.0

1.7

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.7

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.7

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.7

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.40

0.0

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.39

0.39

1.4

1.8

—

(3027135) IgG subclass 1 [Mass/volume] in Serum

0.00

0.39

0.0

1.1

—

5.65

—

(4062490)

0.00

0.39

0.0

1.1

—

(3024139) IgG subclass 3 [Mass/volume] in Serum

0.00

0.39

0.0

1.1

—

0.33

—

(3028192) IgG subclass 2 [Mass/volume] in Serum

0.00

0.39

0.0

1.1

—

3.01

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.40

0.38

1.6

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

132

1277

1.23

0.35

16.3

12.6

39.29

40.99

0.84

1054

(3019225) pH of Specimen

100

1.33

0.35

4.3

5.0

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.32

0.33

6.0

7.8

2.38

1.53

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.29

0.32

6.0

7.8

0.93

0.90

—

(3007164) IgA [Mass/volume] in Serum or Plasma

269

1.19

0.32

1.5

1.3

2.22

2.31

g/l

0.14

169

(3013650) Neutrophils [#/volume] in Blood by Automated count

751

1.13

0.30

9.7

10.1

3.67

3.94

e9/l

0.80

652

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

103

1.29

0.29

1.8

2.0

56.60

72.20

ml/min/173m2

—

(3003694) ABO and Rh group [Type] in Blood

349

1.16

0.29

1.7

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

187

1.21

0.28

4.0

2.3

1.05

0.84

e6/l

0.24

103

(3000494) Fungus identified in Specimen by Culture

151

1.22

0.26

1.6

1.4

—

(40768804) Tissue Pathology biopsy report

509

1.12

0.25

1.6

1.9

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

266

1.16

0.25

4.0

3.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

125

1215

1.15

0.24

8.3

5.0

41.58

39.14

mmol/mol

1.47

119

1160

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

940

0.90

0.23

2.8

3.3

—

(3020891) Body temperature

1.29

0.23

1.4

5.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

144

1.20

0.23

5.6

6.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.23

0.22

1.8

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

145

1.19

0.21

1.2

1.7

—

(3000492) Spirometry study

145

1.19

0.21

1.4

1.5

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.1

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.21

0.0

1.5

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.21

0.0

1.0

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

1.72

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.21

0.0

17.8

—

8.97

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.21

0.0

1.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3015183) Erythrocyte sedimentation rate

0.00

0.21

0.0

1.3

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.21

0.0

2.4

—

536.60

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

1.01

—

(40761511) CBC panel - Blood by Automated count

143

1406

1.22

0.21

15.9

10.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

280

0.87

0.20

3.3

2.0

—

(3044889) 12 lead EKG panel

903

1.10

0.20

4.5

3.3

—

(3000330) Specific gravity of Urine by Test strip

1.26

0.20

7.7

2.7

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.0

—

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

0.00

0.20

0.0

2.5

—

601.78

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

107

1035

1.11

0.20

3.1

46.31

46.54

u/l

0.02

102

1001

(3000963) Hemoglobin [Mass/volume] in Blood

149

1500

0.83

0.20

24.6

17.3

137.37

138.62

g/l

0.52

149

1484

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.21

0.20

2.3

2.2

—

(3024731) MCV [Entitic volume]

149

1499

0.84

0.19

24.3

17.1

90.89

90.73

0.17

149

1484

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

227

0.86

0.19

1.1

1.4

—

(1761868) Lipid panel - Serum or Plasma

605

1.10

0.19

3.7

2.6

—

(3035941) MCH [Entitic mass]

149

1498

0.86

0.19

24.1

17.1

30.37

30.32

0.13

149

1483

(3022313) Gas panel - Capillary blood

1.16

0.19

2.0

2.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.22

0.18

1.0

1.5

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.76

0.17

2.4

1.9

2.12

2.98

mg/l

—

(4035726)

101

1.20

0.17

1.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

244

0.89

0.16

2.6

2.5

0.63

0.68

ug/l

0.15

130

(3008898) HLA-B27 [Presence]

0.76

0.16

1.0

1.1

—

(1002224) Polysomnography panel

0.74

0.16

1.2

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

169

1.14

0.15

1.4

1.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.10

0.15

1.2

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.79

0.15

4.3

3.7

3.99

4.75

pmol/l

—

(4010399)

0.82

0.14

1.1

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

155

1.11

0.09

1.3

1.7

—

(3022621) pH of Urine by Test strip

0.81

0.08

9.0

2.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.02

0.07

1.2

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

217

1.07

0.06

1.5

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

168

1.08

0.06

1.3

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

568

1.03

0.04

5.2

3.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

331

1.03

0.02

6.8

4.8

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

411

1.03

0.02

4.6

3.7

1.47

1.61

ug/l

0.19

380

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

126

0.95

0.00

1.2

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

124

0.97

0.00

1.2

1.9

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

131

1313

0.99

0.00

18.0

11.7

21.77

20.29

mg/l

0.16

106

1011

(3022145) Colonoscopy Study observation

148

1.01

0.00

1.3

1.4

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.3

—

(3016879) Cocaine [Presence] in Urine

0.92

0.00

1.8

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.86

0.00

1.8

1.2

—

(4034850)

0.92

0.00

9.6

7.5

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(4024509)

0.00

0.0

1.3

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.3

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.1

—

8.24

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.3

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.4

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

8.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.89

0.00

1.2

1.0

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

0.0

5.0

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

109.17

—

(3037826) lamoTRIgine [Moles/volume] in Serum or Plasma

0.00

0.0

2.5

—

13.88

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

0.0

1.6

—

(3027944) Amphetamines [Presence] in Urine

0.84

0.00

1.8

1.3

—

(3027008) Opiates [Presence] in Urine

0.84

0.00

1.8

1.2

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.3

—

(3035544) Cardiolipin IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.94

0.00

1.4

1.7

—

(3013293) Extractable nuclear Ab [Presence] in Serum

0.00

0.0

1.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3019060) Gas panel - Arterial blood

0.89

0.00

5.2

6.2

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

2.2

—

61.72

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.02

0.00

1.4

1.3

—

(3017704) Immunofixation for Urine

0.00

0.0

1.6

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

145.17

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.6

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

3.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.88

0.00

2.2

1.4

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

0.0

1.8

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3028300) Cannabinoids [Presence] in Urine

0.84

0.00

1.8

1.2

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.1

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.2

—

1.23

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.1

—

110.00

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.1

—

205.86

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

18.54

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.1

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.1

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(4211845)

0.00

-0.00

0.0

1.3

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.9

—

1.42

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.1

—

7.61

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

2.6

—

101.71

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.6

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: DRY_AMD_EARLY – Dry age-related macular degeneration (includes geographic atrophy), under 50 years

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Dry age-related macular degeneration (includes geographic atrophy), under 50 years

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Dry age-related macular degeneration (includes geographic atrophy), under 50 years (DRY_AMD_EARLY)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints