This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Dry age-related macular degeneration (includes geographic atrophy), under 50 years
DRY_AMD_EARLY
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE<50 Registry filters:
2 out of 7 registries used, show all original rules. |
162 |
4. Check minimum number of eventsNone |
162 |
5. Include endpointsNone |
162 |
6. Filter based on genotype QC (FinnGen only) |
155 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- H35
- Name in latin
- Degeneratio maculae senilis atrophica
Similar endpoints
↥List of similar endpoints to
Dry age-related macular degeneration (includes geographic atrophy), under 50 years
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 155 | 89 | 66 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 46.08 | 46.27 | 45.84 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 162
- Matched controls
- 1620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
4604.1
203.8
155
7
XCW99
NOMESCO Finland
Other investigative procedure of eye
9.1
33.1
49
74
XCK10
NOMESCO Finland
Photography of fundus of eye
9.1
31.6
46
68
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
52.6
31.5
37
9
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
20.2
19
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.9
17.9
24
31
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
17.1
54
161
XCK00
NOMESCO Finland
Perimetry
6.7
14.0
24
41
H35.7
ICD-10 Finland
Separation of retinal layers
23.7
13.7
19
9
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
31.4
13.3
17
6
H35.9
ICD-10 Finland
Retinal disorder, unspecified
76.0
12.8
14
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.0
12.6
30
70
XCD20
NOMESCO Finland
Photoangiography of eye
22.0
11.4
16
8
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.8
11.3
41
132
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
11.8
11.1
20
19
ZXA10
NOMESCO Finland
Bilateral
3.7
11.0
42
140
S01EC01
ATC
acetazolamide; systemic
20.5
10.5
15
8
Z96.1
ICD-10 Finland
Presence of intraocular lens
4.6
9.9
26
65
CJB10
NOMESCO Finland
Laser discission of secondary cataract
10.0
9.3
18
20
3625A
ICD-9 Finland
Other retinal disorders, Degeneration of macula and posterior pole[DEGENERATIO MACULAE NONEXSUDATIVA]
+∞
8.4
8
*
H26.4
ICD-10 Finland
After-cataract
7.6
8.0
18
26
CKC10
NOMESCO Finland
Local photocoagulation of retina
14.3
7.5
12
9
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
83.8
7.5
8
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.1
7.2
21
57
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
58
336
2.13
4.78
5.1
3.6
7.89
5.78
mg/mmol
0.23
39
215
45
241
2.20
4.48
2.6
2.0
2.53
3.04
mg/l
1.03
35
209
20
72
3.03
4.47
4.3
7.7
23.91
25.00
mmol/l
0.42
20
72
77
509
1.98
4.34
6.5
5.4
1.22
1.21
mmol/l
0.64
71
474
53
309
2.06
4.22
3.3
2.7
0.08
0.32
e6/l
2.08
42
223
64
400
1.99
4.20
3.2
2.8
—
—
—
0
0
11
22
5.28
4.08
2.5
4.1
5.24
5.16
kpa
0.11
11
22
81
566
1.86
3.69
8.3
6.7
1.22
1.21
mmol/l
0.58
60
493
75
515
1.85
3.59
11.9
9.0
1.12
1.14
inr
0.07
21
151
51
311
1.93
3.50
4.1
3.4
0.00
0.00
estimate
-0.00
22
105
12
32
3.97
3.47
2.0
1.5
—
—
—
0
0
73
504
1.82
3.38
5.3
5.0
35.04
36.62
g/l
1.70
67
479
31
160
2.16
3.33
2.2
1.6
1366.42
1303.39
nmol/l
0.13
23
126
45
269
1.93
3.25
2.0
2.9
432.07
663.27
ng/l
0.74
33
226
12
36
3.52
3.09
1.2
1.4
365.00
285.83
ug/g
—
5
22
57
388
1.72
2.65
3.5
4.0
2.36
2.35
mmol/l
0.19
50
354
5
7
7.32
2.56
1.4
1.3
1.66
1.70
mmol/l
—
5
7
70
514
1.64
2.40
2.6
3.4
26.97
31.52
u/l
1.27
65
493
8
25
3.31
2.12
2.5
2.8
52.63
57.28
%
—
8
25
8
25
3.31
2.12
1.1
1.2
—
—
—
0
0
81
632
1.56
2.08
4.5
3.1
0.00
0.01
estimate
0.50
24
115
20
108
1.97
1.92
8.3
9.1
125.10
124.73
g/l
0.03
20
102
26
155
1.81
1.87
2.2
2.2
23.69
23.67
%
0.00
20
132
13
60
2.27
1.83
2.1
1.4
—
—
—
0
0
33
213
1.69
1.81
4.2
3.9
19.54
825.68
ng/l
1.62
24
148
33
214
1.68
1.78
2.5
1.7
488.27
446.19
pmol/l
0.18
22
192
11
48
2.39
1.74
1.3
1.4
—
—
—
0
0
7
24
3.00
1.74
1.3
1.3
—
—
—
0
0
19
105
1.92
1.72
4.3
2.8
—
—
—
0
0
78
625
1.48
1.66
6.2
4.3
0.00
0.00
estimate
-0.00
22
104
38
264
1.57
1.56
1.2
1.2
29.82
7.09
u/ml
0.51
13
107
21
124
1.80
1.56
8.2
8.4
4.75
5.13
kpa
0.99
21
113
21
124
1.80
1.56
8.1
8.4
13.08
13.25
kpa
0.05
21
115
43
310
1.53
1.50
1.5
1.3
0.49
1.52
u/ml
1.07
12
100
72
577
1.45
1.49
3.3
2.6
84.78
107.46
ug/l
1.12
66
544
22
134
1.74
1.48
7.9
6.8
104.41
104.30
mmol/l
0.02
22
134
10
192
0.49
1.39
1.8
1.8
—
—
—
0
0
77
631
1.42
1.39
4.7
3.1
0.00
0.00
estimate
-0.00
20
101
81
672
1.41
1.35
5.9
6.3
10.49
10.55
umol/l
0.02
76
648
48
362
1.46
1.34
2.0
1.7
1.66
1.46
mmol/l
0.56
37
315
39
282
1.50
1.34
1.6
1.8
0.89
0.88
mg/l
0.01
30
218
63
505
1.41
1.26
4.8
3.0
—
—
—
0
0
6
25
2.45
1.25
2.0
1.6
—
—
—
0
0
55
432
1.41
1.23
2.2
1.8
87.85
98.61
pmol/l
0.99
30
222
115
1027
1.41
1.18
8.9
7.2
75.64
76.95
u/l
0.15
109
967
56
445
1.39
1.17
4.2
3.0
24.58
32.87
ng/l
0.27
39
257
34
247
1.48
1.14
1.6
1.5
25.87
21.99
nmol/l
0.49
27
214
115
1032
1.39
1.11
5.6
4.0
14.84
14.57
pmol/l
0.56
105
962
36
270
1.43
1.03
1.5
1.5
—
—
—
0
0
5
23
2.21
0.98
1.6
1.8
26.46
25.18
mmol/l
—
5
23
26
189
1.45
0.88
3.2
3.1
2.44
2.43
mmol/l
0.20
21
166
6
30
2.04
0.88
1.5
1.2
—
—
—
0
0
36
280
1.37
0.84
1.2
1.3
19.17
35.68
iu/ml
0.99
13
102
6
32
1.91
0.82
1.2
1.7
—
—
—
0
0
25
183
1.43
0.82
3.4
2.3
2.39
2.09
e6/l
0.08
15
94
149
1423
1.59
0.82
5.6
4.5
2.91
2.94
mmol/l
0.14
139
1357
141
1333
1.45
0.81
5.4
3.9
6.08
5.84
mmol/l
1.20
129
1266
132
1237
1.36
0.77
6.5
4.6
1.81
1.82
mu/l
0.03
123
1160
109
999
1.28
0.73
5.4
3.9
11.50
9.13
mm/h
1.62
101
941
5
26
1.95
0.71
1.2
1.1
—
—
—
0
0
5
26
1.95
0.71
1.0
1.5
—
—
—
0
0
26
200
1.36
0.66
3.7
2.2
0.91
0.89
e6/l
0.02
15
111
153
1484
1.56
0.64
19.3
13.1
75.82
72.99
umol/l
0.88
153
1484
143
1368
1.39
0.62
4.5
3.8
1.42
1.32
mmol/l
0.73
132
1293
49
416
1.26
0.62
4.4
2.6
54.60
60.18
u/l
0.43
43
394
15
107
1.44
0.58
1.5
1.3
57.59
152.55
iu/ml
—
7
45
87
791
1.22
0.57
9.3
10.1
3.73
3.97
e9/l
0.68
80
687
146
1407
1.38
0.54
5.3
4.2
4.81
4.87
mmol/l
0.27
137
1347
27
332
0.78
0.54
3.4
3.7
15.53
20.67
%
—
9
117
137
1317
1.26
0.45
15.3
10.2
85.32
87.12
ml/min/173m2
0.50
117
1096
132
1265
1.23
0.43
8.0
4.9
41.12
39.06
mmol/mol
1.21
126
1208
145
1404
1.31
0.43
5.3
4.2
1.44
1.47
mmol/l
0.33
136
1336
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
8
60
1.35
0.41
2.3
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
2.2
—
0.22
—
0
12
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
3.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
114
1082
1.18
0.40
3.1
3.1
45.09
45.93
u/l
0.06
107
1047
0
19
0.00
0.39
0.0
2.3
—
13.61
—
0
19
9
70
1.30
0.37
1.4
1.8
—
—
—
0
0
12
155
0.76
0.35
1.4
1.9
—
—
—
0
0
18
147
1.25
0.32
5.3
5.9
—
—
—
0
0
8
64
1.26
0.28
2.5
1.9
—
—
—
0
0
5
72
0.68
0.26
2.4
2.2
2.12
2.80
mg/l
—
5
54
5
40
1.26
0.22
1.6
1.1
—
—
—
0
0
5
40
1.26
0.22
1.2
1.3
—
—
—
0
0
96
999
0.90
0.22
2.9
3.3
—
—
—
0
0
5
42
1.20
0.21
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
2.98
—
0
13
13
108
1.22
0.21
1.8
2.0
56.60
73.70
ml/min/173m2
—
5
44
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
156
1568
0.86
0.19
24.3
17.2
137.36
138.59
g/l
0.54
156
1552
7
58
1.22
0.18
1.0
1.5
—
—
—
0
0
6
76
0.78
0.16
2.2
1.3
—
—
—
0
0
62
590
1.08
0.15
3.1
2.4
—
—
—
0
0
19
174
1.10
0.10
1.4
1.9
—
—
—
0
0
156
1566
0.90
0.09
24.6
17.2
40.16
41.11
%
0.85
150
1504
43
412
1.06
0.08
4.6
3.7
1.45
1.61
ug/l
0.23
37
381
16
174
0.91
0.08
1.4
2.0
—
—
—
0
0
23
245
0.93
0.07
1.1
1.4
—
—
—
0
0
23
245
0.93
0.07
2.6
2.5
0.61
0.68
ug/l
0.23
16
130
28
295
0.94
0.07
3.1
2.0
—
—
—
0
0
12
131
0.91
0.06
1.2
1.9
—
—
—
0
0
12
129
0.92
0.03
1.2
1.9
—
—
—
0
0
10
101
0.99
0.00
3.5
3.5
4.12
4.73
pmol/l
—
10
85
138
1376
1.02
0.00
17.7
11.6
21.39
20.08
mg/l
0.15
110
1054
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
61.72
—
0
5
7
71
0.99
0.00
1.3
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
94.40
—
0
5
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
0.00
0.0
2.4
—
115.00
—
0
8
0
8
0.00
0.00
0.0
3.5
—
18.02
—
0
8
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
5
57
0.87
-0.00
1.2
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
205.86
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
-0.00
0.0
1.0
—
127.86
—
0
7
0
7
0.00
-0.00
0.0
2.6
—
98.29
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
51
0.98
-0.00
1.4
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
110.00
—
0
9
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: DRY_AMD_EARLY – Dry age-related macular degeneration (includes geographic atrophy), under 50 years
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).