retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1533 |
4. Check minimum number of eventsNone |
1533 |
5. Include endpointsNone |
1533 |
6. Filter based on genotype QC (FinnGen only) |
1533 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H35
- Name in latin
- Separatio stratorum retinae
Similar endpoints
↥List of similar endpoints to
Separation of retinal layers (serosa)
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10471 | 3365 | 7063 |
| Only index persons | 10254 | 3320 | 6934 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.10 | 0.20 |
| Only index persons | 0.22 | 0.12 | 0.26 |
| Median age at first event (years) | |||
| Whole population | 49.96 | 56.13 | 47.11 |
| Only index persons | 49.96 | 56.05 | 47.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1533 | 576 | 957 |
| Unadjusted period prevalence (%) | 0.34 | 0.20 | 0.42 |
| Median age at first event (years) | 52.34 | 54.13 | 51.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1365
- Matched controls
- 13648
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
793.5
323.0
309
5
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
1002.1
323.0
311
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
323.0
1365
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
22.9
292.0
441
279
XCD20
NOMESCO Finland
Photoangiography of eye
345.4
281.7
276
10
XCW99
NOMESCO Finland
Other investigative procedure of eye
16.1
276.3
484
450
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
630.2
222.0
214
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
20.8
207.1
319
197
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
98.9
178.8
195
23
XCK10
NOMESCO Finland
Photography of fundus of eye
9.6
165.0
371
512
CKC12
NOMESCO Finland
Photocoagulation of retina
111.8
155.1
167
17
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
1627.7
150.9
144
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
1182.2
113.3
109
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
78.2
349
1038
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
+∞
77.9
74
*
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
404.6
77.6
77
*
1LA01
NOMESCO Finland
NA
+∞
61.9
59
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
154.0
56.3
59
*
ZX198
NOMESCO Finland
Other local administration
31.4
47.5
63
21
S01BC03
ATC
diclofenac; ophthalmic
9.8
45.9
95
103
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
45.0
43
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
451.9
44.5
44
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
451.9
44.5
44
*
ZXA10
NOMESCO Finland
Bilateral
2.9
44.4
309
1232
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
44.0
42
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
137.2
37.9
40
*
H35.37
ICD-10 Finland
Macular holes
195.3
37.0
38
*
1LA05
NOMESCO Finland
NA
+∞
36.6
35
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
32.4
35.9
47
15
S01EC01
ATC
acetazolamide; systemic
10.5
33.9
67
67
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
37.4
31.6
40
11
WX140
NOMESCO Finland
Parabulbar anesthesy
10.2
30.1
60
61
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.3
28.3
150
486
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
287.1
27.8
28
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
287.1
27.8
28
*
XCK00
NOMESCO Finland
Perimetry
3.8
26.2
117
330
H34.8
ICD-10 Finland
Other retinal vascular occlusions
74.2
25.9
29
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
265.4
25.8
26
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
91.8
24.7
27
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.1
23.7
298
1571
S01BC05
ATC
ketorolac; ophthalmic
5.4
23.1
71
138
XCH00
NOMESCO Finland
Eye pressure measurement
5.8
23.0
66
118
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
+∞
23.0
22
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.2
22.1
54
78
H25.1
ICD-10 Finland
Senile nuclear cataract
2.2
20.8
245
1248
H35.4
ICD-10 Finland
Peripheral retinal degeneration
+∞
19.8
19
*
H35.6
ICD-10 Finland
Retinal haemorrhage
202.8
19.6
20
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.2
19.1
60
120
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
18.9
477
3205
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
18.8
102
336
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
53.3
18.0
21
*
H35.36
ICD-10 Finland
Macular cyst
+∞
17.7
17
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.8
17.7
120
458
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
42.6
17.3
21
5
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
17.6
17.0
26
15
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
172.0
16.5
17
*
H33.2
ICD-10 Finland
Serous retinal detachment
172.0
16.5
17
*
ZXA05
NOMESCO Finland
Left side
1.8
16.3
326
2013
H33.5
ICD-10 Finland
Other retinal detachments
18.8
16.0
24
13
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.3
15.8
80
251
TCK00
NOMESCO Finland
Photosensitisation of choroid and retina
+∞
15.7
15
*
ZX120
NOMESCO Finland
Intravenous
2.3
15.3
147
679
ZXA00
NOMESCO Finland
Right side
1.7
14.7
339
2184
H26.4
ICD-10 Finland
After-cataract
2.9
14.7
89
316
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
8.3
13.8
30
37
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
13.6
13
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.7
13.4
371
2507
L04AX01
ATC
azathioprine; systemic
3.0
12.8
74
256
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
12.5
12
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
131.2
12.5
13
*
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
30.3
11.7
15
5
S01ED51
ATC
timolol, combinations; ophthalmic
2.6
11.4
83
331
F05
ICPC
Visual disturbance other
4.0
11.3
44
112
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
11.3
11.1
20
18
H02AB06
ATC
prednisolone; systemic
1.5
10.3
570
4476
L04AA01
ATC
[U] ciclosporin; systemic
4.6
9.9
33
73
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
9.7
115
581
CA1ME
NOMESCO Finland
Ultrasound oculometry
13.5
9.7
16
12
S01ED01
ATC
timolol; ophthalmic
3.5
9.6
43
125
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
9.4
326
2300
1LA04
NOMESCO Finland
NA
+∞
9.4
9
*
A02BC02
ATC
pantoprazole; systemic
1.4
9.2
801
6811
H43.1
ICD-10 Finland
Vitreous haemorrhage
6.6
9.0
22
34
N02BE01
ATC
paracetamol; systemic, rectal
1.5
8.4
1091
9922
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
+∞
8.3
8
*
L04AA06
ATC
mycophenolic acid; systemic
3.7
8.0
33
91
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
4.7
7.8
25
54
C03DA01
ATC
spironolactone; oral
1.9
7.8
120
672
H25.0
ICD-10 Finland
Senile incipient cataract
2.4
7.7
63
272
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.1
7.6
39
128
H02AB04
ATC
methylprednisolone; systemic
1.7
7.4
164
1029
C08CA01
ATC
amlodipine; oral
1.4
7.3
399
3073
H3600, E103
ICD-10 Finland
NA
+∞
7.3
7
*
H3600, E113
ICD-10 Finland
NA
+∞
7.3
7
*
H3601, E113
ICD-10 Finland
NA
+∞
7.3
7
*
H40.0
ICD-10 Finland
Glaucoma suspect
2.0
7.2
85
432
H20.1
ICD-10 Finland
Chronic iridocyclitis
6.3
7.2
18
29
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
6.9
120
698
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
13.8
6.9
11
8
A02BC05
ATC
esomeprazole; systemic
1.4
6.8
482
3880
K85
ICPC
Elevated blood pressure
1.6
6.8
160
1021
L04AD01
ATC
ciclosporin; systemic
3.1
6.8
35
116
S01EC54
ATC
brinzolamide, combinations; ophthalmic
5.7
6.8
18
32
H35
ICD-10 Finland
Other retinal disorders
40.3
6.8
8
*
Z94.0
ICD-10 Finland
Kidney transplant status
4.5
6.7
22
50
S01EC04
ATC
brinzolamide; ophthalmic
2.9
6.5
36
125
H53.4
ICD-10 Finland
Visual field defects
3.2
6.5
31
97
127
Kela drug reimbursment
Transplant complication
3.5
6.5
28
81
H34.2
ICD-10 Finland
Other retinal artery occlusions
70.2
6.4
7
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
6.3
125
761
V03AE01
ATC
polystyrene sulfonate; oral
5.5
6.3
17
31
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
6.3
6
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
6.3
6
*
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
+∞
6.3
6
*
H02AB09
ATC
hydrocortisone; systemic
3.2
6.2
30
95
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
26.8
6.2
8
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
6.3
6.2
15
24
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.2
6.1
29
91
114
Kela drug reimbursment
Glaucoma
1.9
6.1
80
426
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINASEPAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINASEPAR | 0.841 [0.72, 0.98] | 0.026 |
| Birth year | 0.995 [0.99, 1.0] | 0.238 |
During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 3022 females with H7_RETINASEPAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINASEPAR | 0.78 [0.68, 0.89] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 454 out of 6289 males with H7_RETINASEPAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINASEPAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.074% | 0.139% |
| 5 | 0.577% | 0.861% |
| 10 | 1.373% | 2.266% |
| 15 | 2.356% | 4.337% |
| 20 | 4.263% | 7.317% |
Relationships between endpoints
↥Index endpoint: H7_RETINASEPAR – Separation of retinal layers (serosa)
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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