Separation of retinal layers (serosa)

H7_RETINASEPAR

retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H35.7
  • Cause of death: ICD-10 H35.7

2 out of 7 registries used, show all original rules.

1533

4. Check minimum number of events

None

1533

5. Include endpoints

None

1533

6. Filter based on genotype QC (FinnGen only)

1533

Control definitions (FinnGen only)

Control exclude
H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H35
Name in latin
Separatio stratorum retinae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10471 3365 7063
Only index persons 10254 3320 6934
Unadjusted period prevalence (%)
Whole population 0.16 0.10 0.20
Only index persons 0.22 0.12 0.26
Median age at first event (years)
Whole population 49.96 56.13 47.11
Only index persons 49.96 56.05 47.04

-FinnGen-

Key figures

All Female Male
Number of individuals 1533 576 957
Unadjusted period prevalence (%) 0.34 0.20 0.42
Median age at first event (years) 52.34 54.13 51.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1365
Matched controls
13648
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
793.5
323.0
309
5
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
1002.1
323.0
311
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
323.0
1365
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
22.9
292.0
441
279
XCD20
NOMESCO Finland
Photoangiography of eye
345.4
281.7
276
10
XCW99
NOMESCO Finland
Other investigative procedure of eye
16.1
276.3
484
450
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
630.2
222.0
214
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
20.8
207.1
319
197
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
98.9
178.8
195
23
XCK10
NOMESCO Finland
Photography of fundus of eye
9.6
165.0
371
512
CKC12
NOMESCO Finland
Photocoagulation of retina
111.8
155.1
167
17
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
1627.7
150.9
144
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
1182.2
113.3
109
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
78.2
349
1038
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
+∞
77.9
74
*
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
404.6
77.6
77
*
1LA01
NOMESCO Finland
NA
+∞
61.9
59
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
154.0
56.3
59
*
ZX198
NOMESCO Finland
Other local administration
31.4
47.5
63
21
S01BC03
ATC
diclofenac; ophthalmic
9.8
45.9
95
103
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
45.0
43
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
451.9
44.5
44
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
451.9
44.5
44
*
ZXA10
NOMESCO Finland
Bilateral
2.9
44.4
309
1232
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
44.0
42
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
137.2
37.9
40
*
H35.37
ICD-10 Finland
Macular holes
195.3
37.0
38
*
1LA05
NOMESCO Finland
NA
+∞
36.6
35
*
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
32.4
35.9
47
15
S01EC01
ATC
acetazolamide; systemic
10.5
33.9
67
67
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
37.4
31.6
40
11
WX140
NOMESCO Finland
Parabulbar anesthesy
10.2
30.1
60
61
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.3
28.3
150
486
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
287.1
27.8
28
*
CKD40
NOMESCO Finland
Endophotocoagulation of retina
287.1
27.8
28
*
XCK00
NOMESCO Finland
Perimetry
3.8
26.2
117
330
H34.8
ICD-10 Finland
Other retinal vascular occlusions
74.2
25.9
29
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
265.4
25.8
26
*
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
91.8
24.7
27
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.1
23.7
298
1571
S01BC05
ATC
ketorolac; ophthalmic
5.4
23.1
71
138
XCH00
NOMESCO Finland
Eye pressure measurement
5.8
23.0
66
118
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
+∞
23.0
22
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.2
22.1
54
78
H25.1
ICD-10 Finland
Senile nuclear cataract
2.2
20.8
245
1248
H35.4
ICD-10 Finland
Peripheral retinal degeneration
+∞
19.8
19
*
H35.6
ICD-10 Finland
Retinal haemorrhage
202.8
19.6
20
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.2
19.1
60
120
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
18.9
477
3205
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
18.8
102
336
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
53.3
18.0
21
*
H35.36
ICD-10 Finland
Macular cyst
+∞
17.7
17
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.8
17.7
120
458
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
42.6
17.3
21
5
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
17.6
17.0
26
15
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
172.0
16.5
17
*
H33.2
ICD-10 Finland
Serous retinal detachment
172.0
16.5
17
*
ZXA05
NOMESCO Finland
Left side
1.8
16.3
326
2013
H33.5
ICD-10 Finland
Other retinal detachments
18.8
16.0
24
13
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.3
15.8
80
251
TCK00
NOMESCO Finland
Photosensitisation of choroid and retina
+∞
15.7
15
*
ZX120
NOMESCO Finland
Intravenous
2.3
15.3
147
679
ZXA00
NOMESCO Finland
Right side
1.7
14.7
339
2184
H26.4
ICD-10 Finland
After-cataract
2.9
14.7
89
316
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
8.3
13.8
30
37
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
13.6
13
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.7
13.4
371
2507
L04AX01
ATC
azathioprine; systemic
3.0
12.8
74
256
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
12.5
12
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
131.2
12.5
13
*
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
30.3
11.7
15
5
S01ED51
ATC
timolol, combinations; ophthalmic
2.6
11.4
83
331
F05
ICPC
Visual disturbance other
4.0
11.3
44
112
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
11.3
11.1
20
18
H02AB06
ATC
prednisolone; systemic
1.5
10.3
570
4476
L04AA01
ATC
[U] ciclosporin; systemic
4.6
9.9
33
73
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
9.7
115
581
CA1ME
NOMESCO Finland
Ultrasound oculometry
13.5
9.7
16
12
S01ED01
ATC
timolol; ophthalmic
3.5
9.6
43
125
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
9.4
326
2300
1LA04
NOMESCO Finland
NA
+∞
9.4
9
*
A02BC02
ATC
pantoprazole; systemic
1.4
9.2
801
6811
H43.1
ICD-10 Finland
Vitreous haemorrhage
6.6
9.0
22
34
N02BE01
ATC
paracetamol; systemic, rectal
1.5
8.4
1091
9922
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
+∞
8.3
8
*
L04AA06
ATC
mycophenolic acid; systemic
3.7
8.0
33
91
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
4.7
7.8
25
54
C03DA01
ATC
spironolactone; oral
1.9
7.8
120
672
H25.0
ICD-10 Finland
Senile incipient cataract
2.4
7.7
63
272
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.1
7.6
39
128
H02AB04
ATC
methylprednisolone; systemic
1.7
7.4
164
1029
C08CA01
ATC
amlodipine; oral
1.4
7.3
399
3073
H3600, E103
ICD-10 Finland
NA
+∞
7.3
7
*
H3600, E113
ICD-10 Finland
NA
+∞
7.3
7
*
H3601, E113
ICD-10 Finland
NA
+∞
7.3
7
*
H40.0
ICD-10 Finland
Glaucoma suspect
2.0
7.2
85
432
H20.1
ICD-10 Finland
Chronic iridocyclitis
6.3
7.2
18
29
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
6.9
120
698
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
13.8
6.9
11
8
A02BC05
ATC
esomeprazole; systemic
1.4
6.8
482
3880
K85
ICPC
Elevated blood pressure
1.6
6.8
160
1021
L04AD01
ATC
ciclosporin; systemic
3.1
6.8
35
116
S01EC54
ATC
brinzolamide, combinations; ophthalmic
5.7
6.8
18
32
H35
ICD-10 Finland
Other retinal disorders
40.3
6.8
8
*
Z94.0
ICD-10 Finland
Kidney transplant status
4.5
6.7
22
50
S01EC04
ATC
brinzolamide; ophthalmic
2.9
6.5
36
125
H53.4
ICD-10 Finland
Visual field defects
3.2
6.5
31
97
127
Kela drug reimbursment
Transplant complication
3.5
6.5
28
81
H34.2
ICD-10 Finland
Other retinal artery occlusions
70.2
6.4
7
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
6.3
125
761
V03AE01
ATC
polystyrene sulfonate; oral
5.5
6.3
17
31
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
6.3
6
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
6.3
6
*
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
+∞
6.3
6
*
H02AB09
ATC
hydrocortisone; systemic
3.2
6.2
30
95
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
26.8
6.2
8
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
6.3
6.2
15
24
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.2
6.1
29
91
114
Kela drug reimbursment
Glaucoma
1.9
6.1
80
426

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1118
9662
1.58
13.76
9.5
7.6
78.5
77.1
u/l
0.41
1055
9151
1426
13190
2.16
13.62
19.1
15.7
4.0
4.0
mmol/l
0.31
1392
12893
1418
13135
2.06
12.74
18.9
15.6
139.8
139.7
mmol/l
0.13
1384
12846
765
6179
1.48
12.38
7.5
6.0
0.0
0.0
e9/l
0.34
678
5399
760
6158
1.46
11.94
7.4
6.0
0.6
0.6
e9/l
0.02
672
5377
27
58
4.72
11.91
22.9
25.7
102.6
127.0
ug/l
1.19
21
44
1376
12667
1.84
11.89
17.1
13.6
23.6
24.2
mg/l
0.25
1097
9995
1058
9167
1.50
11.64
4.9
3.9
12.4
11.2
mm/h
1.72
988
8550
773
6310
1.45
11.53
7.5
6.0
1.8
2.0
e9/l
1.57
694
5599
721
5836
1.44
11.09
7.4
6.0
57.3
57.0
%
0.32
680
5496
777
6389
1.44
10.91
7.7
6.2
0.2
0.2
e9/l
0.46
695
5656
728
5917
1.44
10.88
7.7
6.2
27.6
28.1
%
0.62
686
5542
1459
13761
2.25
10.87
12.9
10.1
28.6
29.1
u/l
0.42
1415
13356
609
4794
1.45
10.78
3.4
2.7
177.4
158.4
ug/l
0.47
565
4447
713
5784
1.44
10.70
7.9
6.5
8.9
8.7
%
0.37
675
5445
707
5755
1.42
10.27
7.6
6.2
2.9
2.9
%
0.10
665
5395
1424
13347
1.94
10.26
16.2
12.8
—
—
—
0
0
850
7159
1.42
10.13
10.2
9.3
4.2
4.1
e9/l
0.55
757
6305
1496
14317
2.86
9.88
25.2
19.9
137.9
138.9
g/l
1.69
1476
14141
1495
14313
2.80
9.67
24.9
19.7
30.4
30.4
pg
0.07
1476
14142
1495
14314
2.79
9.65
25.0
19.7
91.3
91.0
fl
2.25
1475
14143
531
4139
1.43
9.65
7.6
6.0
—
—
—
0
0
1041
9133
1.44
9.61
3.9
3.6
14.8
14.8
pmol/l
0.04
961
8377
1495
14316
2.79
9.61
25.1
19.8
4.6
4.6
e12/l
1.60
1460
13963
1495
14318
2.78
9.56
25.1
19.8
6.7
6.7
e9/l
0.82
1463
13962
1494
14305
2.74
9.54
25.1
19.8
247.1
246.1
e9/l
0.24
1462
13985
719
5924
1.40
9.48
9.7
7.0
1.2
1.2
mmol/l
0.41
619
5027
682
5587
1.40
9.21
7.8
6.2
0.7
0.7
%
0.12
644
5244
600
4820
1.40
9.04
2.2
2.0
—
—
—
0
0
592
4757
1.40
8.86
2.0
1.9
97.0
95.3
pmol/l
0.37
320
2573
769
6465
1.38
8.71
7.3
6.5
11.4
11.7
umol/l
0.27
719
6177
1231
11233
1.49
8.55
4.7
4.3
1.8
2.0
mu/l
0.81
1144
10338
22
53
4.20
8.47
1.6
1.5
—
—
—
0
0
470
3662
1.41
8.30
3.9
3.1
498.0
276.6
mg/l
0.41
313
2361
948
8293
1.38
8.13
5.0
4.0
—
—
—
0
0
256
1784
1.52
8.06
3.7
2.6
13.0
13.6
umol/l
0.81
239
1666
494
3898
1.39
8.05
3.1
2.6
60.6
58.3
u/l
0.27
455
3629
655
5427
1.36
7.84
8.6
6.3
1.2
1.2
mmol/l
0.41
606
4943
486
3847
1.39
7.71
4.5
3.8
11.6
7.8
mg/mmol
0.91
328
2474
1399
13200
1.68
7.68
5.3
4.8
2.8
2.8
mmol/l
0.54
1305
12317
883
7676
1.35
7.65
4.7
4.0
60.9
1906.3
e6/l
—
9
111
486
3889
1.37
7.09
3.8
3.1
8.1
8.3
mmol/l
0.36
427
3291
363
2772
1.41
7.02
2.7
2.1
2.8
3.0
mg/l
0.43
308
2350
1377
12996
1.59
6.88
4.8
4.4
4.7
4.7
mmol/l
0.10
1285
12189
11
17
6.51
6.78
11.2
8.9
5.1
6.1
mmol/l
0.65
11
17
433
3427
1.37
6.71
1.8
1.6
1.4
1.5
mmol/l
0.25
370
2927
436
3463
1.36
6.58
6.3
4.2
7.4
7.4
ph
0.90
66
681
1369
12932
1.55
6.48
4.8
4.3
1.4
1.4
mmol/l
0.01
1278
12074
220
1552
1.49
6.47
4.0
2.6
22.6
23.8
%
0.78
188
1333
465
3742
1.35
6.42
2.2
2.2
157.2
277.7
u/l
2.38
444
3536
669
5702
1.31
6.10
4.6
3.9
—
—
—
0
0
837
7352
1.30
6.09
5.9
4.9
6.8
6.7
mmol/l
0.92
787
6930
245
1806
1.42
5.71
2.2
2.1
—
—
—
0
0
227
1654
1.44
5.63
3.9
2.5
2.3
2.3
g/l
0.54
215
1547
1281
12015
1.40
5.60
6.0
5.4
39.6
39.4
mmol/mol
0.27
1204
11251
432
3501
1.33
5.55
3.1
2.6
1919.1
5293.1
umol/l
1.87
384
3090
19
58
3.30
5.31
6.2
4.8
—
—
—
0
0
1324
12515
1.42
5.31
4.3
3.9
1.4
1.4
mmol/l
0.34
1226
11646
1262
11848
1.37
5.14
17.7
14.3
40.7
40.9
%
0.28
937
8813
140
944
1.53
5.11
3.8
2.8
66.0
70.9
e9/l
1.14
111
734
193
1401
1.43
4.88
2.0
1.7
—
—
—
0
0
42
203
2.10
4.78
1.2
1.1
0.7
1.8
u/ml
0.85
19
82
32
138
2.35
4.77
4.2
4.7
—
—
—
0
0
677
5906
1.26
4.74
4.0
3.3
0.0
0.0
estimate
0.00
123
1107
192
1404
1.42
4.66
2.6
2.9
7.6
8.3
umol/l
0.27
171
1233
116
767
1.55
4.64
1.3
1.3
139.8
237.9
u/ml
1.29
107
703
85
522
1.67
4.60
2.1
1.9
1.5
1.6
g/l
0.45
78
448
681
5963
1.26
4.56
4.1
3.3
0.0
0.0
estimate
0.50
124
1072
175
1264
1.43
4.55
3.5
2.7
1.8
1.8
%
0.07
161
1139
407
3350
1.29
4.54
4.9
4.4
—
—
—
0
0
347
2799
1.31
4.50
5.4
4.6
—
—
—
0
0
586
5049
1.26
4.49
9.5
9.1
1.3
1.2
inr
0.37
159
1453
156
1109
1.45
4.42
2.9
2.2
366.7
368.9
nmol/l
0.05
147
1026
16
50
3.22
4.34
1.0
1.0
—
—
—
0
0
536
4587
1.26
4.32
3.7
3.2
—
5.6
—
0
5
1318
12537
1.37
4.30
4.9
4.4
5.9
6.0
mmol/l
0.54
1208
11597
61
349
1.78
4.27
1.4
1.4
6.4
7.3
u/l
0.28
52
288
122
832
1.51
4.26
2.0
3.2
4.3
4.1
e9/l
0.40
93
673
674
5927
1.24
4.25
5.4
4.5
0.0
0.0
estimate
0.50
125
1140
134
933
1.48
4.23
5.4
4.5
0.0
0.5
%
0.62
40
241
192
1429
1.39
4.22
2.5
2.3
13.1
13.6
nmol/l
0.46
180
1299
60
343
1.78
4.22
3.2
1.4
0.2
0.2
g/l
0.46
60
322
147
1046
1.45
4.15
5.3
4.4
0.7
0.9
%
0.64
46
312
602
5245
1.24
4.08
7.0
5.0
35.6
35.8
g/l
0.58
573
4912
61
354
1.75
4.08
3.2
1.4
1.2
1.2
g/l
0.06
61
332
35
169
2.10
4.03
1.1
1.0
0.6
2.9
u/ml
—
8
39
191
1433
1.38
4.00
3.1
2.4
222.3
142.7
ug/g
1.00
156
1174
18
64
2.83
3.96
1.9
1.5
1.9
1.8
u/field
0.01
13
49
1131
10580
1.26
3.89
20.0
16.6
13.7
13.6
%
0.58
1113
10346
29
132
2.22
3.87
1.3
1.2
—
—
—
0
0
37
186
2.01
3.85
1.3
1.2
4.2
6.4
u/ml
0.47
15
80
189
1425
1.37
3.85
1.5
1.3
—
—
—
0
0
353
2909
1.28
3.83
3.0
2.4
—
—
—
0
0
138
987
1.44
3.81
5.5
4.5
0.0
0.1
%
2.71
41
286
134
954
1.44
3.79
4.9
4.2
0.4
0.6
%
0.52
36
232
487
4177
1.24
3.74
4.3
3.6
87.1
93.9
e6/l
0.08
366
3042
150
1094
1.41
3.72
6.6
3.7
5.8
5.9
kpa
0.41
144
1067
30
141
2.15
3.72
1.1
1.0
2.7
4.8
u/ml
0.54
12
49
988
9126
1.23
3.70
3.9
3.7
—
—
—
0
0
182
1373
1.37
3.69
2.2
1.6
—
—
—
0
0
15
50
3.02
3.69
1.3
1.0
—
—
—
0
0
18
67
2.71
3.66
1.6
1.9
—
48.3
—
0
5
375
3129
1.26
3.66
7.5
6.9
—
—
—
0
0
13
40
3.27
3.63
1.2
1.1
—
—
—
0
0
86
564
1.56
3.62
8.5
4.0
23.9
24.4
mmol/l
0.86
76
513
29
136
2.15
3.62
2.7
2.4
—
—
—
0
0
30
143
2.12
3.60
1.1
1.4
211.9
303.7
pmol/l
1.51
23
119
286
2312
1.29
3.60
3.0
2.7
558.4
568.0
mosm/kgh2o
0.29
248
1989
155
1145
1.39
3.58
13.4
7.9
10.6
9.2
mmol/l
1.76
147
1092
35
179
1.98
3.50
1.1
1.1
4.0
4.4
u/ml
0.06
22
84
43
236
1.85
3.49
2.2
1.4
112.4
122.6
u/ml
—
8
47
88
586
1.53
3.47
2.5
2.3
—
—
—
0
0
152
1127
1.39
3.44
6.2
3.8
—
7.4
—
0
9
28
133
2.13
3.40
2.5
2.4
—
—
—
0
0
34
174
1.98
3.40
1.1
1.1
1.1
1.6
u/ml
0.16
15
67
305
2505
1.27
3.37
2.9
2.5
4.3
4.7
e6/l
0.18
269
2225
1170
11051
1.25
3.35
21.5
17.0
332.9
333.8
g/l
3.06
1165
10976
194
1503
1.33
3.32
2.1
1.5
—
—
—
0
0
45
255
1.79
3.32
2.2
1.5
—
—
—
0
0
376
3171
1.25
3.31
4.8
4.1
91.7
90.5
%
0.42
365
3097
85
569
1.52
3.29
5.4
3.6
—
—
—
0
0
50
296
1.71
3.19
1.4
1.2
2.4
2.7
u/ml
—
8
23
131
961
1.40
3.17
2.8
2.8
67.2
66.7
g/l
0.36
120
889
615
5475
1.21
3.16
10.7
9.5
0.0
0.0
e9/l
0.11
518
4536
423
3631
1.23
3.14
3.8
3.2
28.8
79.5
e6/l
1.68
340
2812
152
1145
1.36
3.13
2.4
2.6
30.6
82.3
u/l
0.70
133
1010
146
1093
1.37
3.13
6.9
3.7
1.4
2.2
mmol/l
2.03
119
878
105
744
1.44
3.09
5.4
3.1
131.7
131.3
g/l
0.05
100
731
43
247
1.76
3.05
1.7
1.2
326.3
272.9
u/ml
0.58
34
160
253
2056
1.28
3.04
3.2
2.7
0.9
1.0
e6/l
0.29
169
1166
390
3332
1.23
3.02
3.7
3.1
0.3
0.4
e6/l
1.96
319
2520
393
3361
1.23
3.01
2.9
3.0
1099.0
1127.3
ng/l
0.07
335
2834
315
2632
1.25
2.99
1.7
1.5
20.1
20.7
nmol/l
0.27
274
2276
123
906
1.39
2.92
1.8
1.5
—
—
—
0
0
30
156
1.94
2.91
2.1
1.6
—
—
—
0
0
57
359
1.61
2.90
3.5
3.3
—
—
—
0
0
137
1029
1.36
2.89
4.4
3.2
—
—
—
0
0
79
539
1.49
2.83
1.8
1.7
—
—
—
0
0
57
362
1.60
2.81
1.4
1.5
246.9
283.3
ug/g
0.80
36
209
435
3783
1.21
2.80
3.1
2.4
—
—
—
0
0
248
2033
1.26
2.78
4.8
3.7
0.8
0.8
mmol/l
0.64
240
1916
45
270
1.69
2.77
1.5
1.9
4.0
5.3
iu/l
0.32
17
88
295
2468
1.24
2.76
1.3
1.2
1.7
1.9
u/ml
0.05
83
689
326
2757
1.23
2.76
2.2
1.7
1.5
1.1
mg/l
0.64
250
2107
130
976
1.36
2.76
2.2
2.7
10.5
10.6
g/l
0.11
116
895
28
145
1.95
2.76
1.3
1.2
—
—
—
0
0
22
104
2.13
2.75
1.2
2.6
—
—
—
0
0
537
4771
1.19
2.73
3.5
3.5
43.1
48.5
ng/l
0.15
384
3262
250
2056
1.26
2.72
1.9
1.7
1141.3
1178.8
nmol/l
0.23
202
1581
29
153
1.91
2.71
1.1
1.1
1.2
2.7
u/ml
1.04
16
55
113
832
1.39
2.71
7.0
4.0
136.9
86.0
ng/l
2.41
104
743
382
3291
1.21
2.70
3.6
3.0
—
—
—
0
0
50
312
1.62
2.66
1.8
1.6
25026.5
15405.1
e6/l
0.53
36
235
149
1152
1.32
2.62
5.2
4.1
—
—
—
0
0
135
1029
1.34
2.61
11.2
9.8
—
—
—
0
0
190
1519
1.29
2.61
32.2
21.9
1.5
1.3
inr
0.53
15
189
26
134
1.96
2.61
1.4
1.2
30125.9
95585.2
e6/l
0.65
16
96
192
1542
1.28
2.55
1.6
1.5
—
—
—
0
0
5
7
7.16
2.55
4.0
2.9
—
—
—
0
0
352
3025
1.21
2.54
3.2
2.9
—
—
—
0
0
238
1963
1.25
2.53
1.4
1.3
9.4
10.3
u/ml
0.09
107
799
73
507
1.46
2.44
1.1
1.2
—
—
—
0
0
198
1608
1.27
2.41
8.7
7.7
104.5
104.3
mmol/l
0.19
193
1569
198
1609
1.26
2.40
1.5
1.3
559.3
452.9
titre
0.35
56
323
24
125
1.93
2.36
2.7
2.4
—
—
—
0
0
56
371
1.53
2.35
1.5
1.2
—
—
—
0
0
44
276
1.61
2.33
6.4
2.9
—
—
—
0
0
642
5851
1.17
2.32
4.7
4.3
2.2
2.1
ug/l
0.36
588
5318
104
777
1.36
2.32
5.4
3.5
7.4
7.4
ph
—
9
101
211
1737
1.25
2.29
1.2
1.2
—
—
—
0
0
199
1628
1.26
2.28
12.6
6.1
1.1
1.0
mmol/l
1.94
191
1511
234
1950
1.24
2.28
3.7
2.1
29.0
29.8
s
1.73
226
1892
83
600
1.41
2.26
1.9
1.9
37.1
37.9
nmol/l
0.16
83
580
119
913
1.33
2.24
5.5
2.8
5.1
4.7
kpa
0.91
113
891
245
2060
1.23
2.19
1.4
1.3
28.7
32.6
iu/ml
0.23
81
648
75
536
1.42
2.18
7.3
5.5
1.8
1.7
%
0.41
69
505
445
3957
1.18
2.16
4.1
3.4
2.3
2.4
mmol/l
0.28
396
3498
169
1366
1.27
2.15
1.5
1.4
—
—
—
0
0
367
3213
1.19
2.14
4.6
3.7
0.0
0.0
estimate
1.08
125
1087
52
348
1.51
2.11
1.2
1.3
148.6
87.6
titre
—
7
38
263
2238
1.21
2.09
1.5
1.5
2.5
2.5
g/l
0.01
157
1418
16
75
2.15
2.08
1.3
1.6
—
—
—
0
0
40
253
1.60
2.08
3.2
3.3
4.1
4.2
e9/l
0.09
40
253
9
31
2.91
2.07
1.1
2.0
—
—
—
0
0
109
836
1.33
2.07
2.6
2.4
19.2
18.5
au/ml
—
8
45
103
788
1.33
2.00
5.5
3.5
5.0
5.2
kpa
1.57
97
735
73
529
1.40
1.99
7.5
5.6
0.8
0.9
%
0.81
67
498
36
225
1.61
1.97
1.4
1.2
—
—
—
0
0
312
2715
1.19
1.95
4.3
3.3
—
—
—
0
0
41
266
1.56
1.93
1.4
1.3
—
—
—
0
0
40
260
1.55
1.88
3.5
3.6
57.0
56.9
%
0.02
40
260
36
229
1.59
1.85
1.4
1.4
—
—
—
0
0
102
791
1.31
1.82
1.7
2.5
—
—
—
0
0
19
101
1.89
1.81
2.6
1.9
19.8
18.8
nmol/l
0.17
19
95
62
445
1.41
1.81
1.8
1.9
197.6
212.4
pmol/l
0.75
57
423
98
759
1.31
1.77
1.7
1.8
1.3
1.3
g/l
0.19
89
700
223
1901
1.20
1.75
3.5
2.9
1.6
1.8
e6/l
0.11
138
1018
112
887
1.28
1.72
1.4
1.4
—
—
—
0
0
68
501
1.37
1.71
2.2
2.6
—
—
—
0
0
5
13
3.85
1.71
1.0
1.5
138.4
117.9
ng/l
—
5
13
396
3548
1.16
1.71
3.9
3.7
—
—
—
0
0
14
68
2.07
1.70
1.0
1.0
—
—
—
0
0
32
203
1.59
1.69
2.1
1.7
0.8
0.9
g/l
0.17
25
157
12
55
2.19
1.67
1.0
1.0
4.8
0.4
u/ml
—
5
17
7
25
2.81
1.65
1.0
1.0
—
—
—
0
0
50
352
1.43
1.64
1.2
1.1
—
—
—
0
0
64
471
1.37
1.64
4.0
2.0
22.3
21.5
s
0.42
55
420
33
213
1.56
1.63
1.4
1.4
—
—
—
0
0
283
2482
1.17
1.61
1.8
1.7
422.3
32637005.0
pmol/l
2.39
236
2105
60
438
1.38
1.61
1.4
1.2
0.8
0.9
u/ml
—
9
37
298
2625
1.17
1.61
4.7
3.6
1.0
1.0
kg/l
0.15
39
360
386
3471
1.15
1.58
2.8
2.8
0.7
0.7
ug/l
0.14
262
2139
11
50
2.21
1.57
1.0
1.2
—
—
—
0
0
17
92
1.86
1.56
2.4
2.0
0.4
1.7
u/field
—
9
43
8
33
2.43
1.54
4.5
2.6
—
—
—
0
0
10
205
0.48
1.51
3.8
5.8
411.3
361.8
umol/l
—
10
186
23
139
1.66
1.48
1.4
1.4
—
—
—
0
0
180
1534
1.20
1.45
1.3
1.3
—
—
—
0
0
26
164
1.60
1.43
1.2
1.4
0.6
0.7
nmol/l
0.10
26
157
30
196
1.54
1.43
1.2
1.2
—
—
—
0
0
19
110
1.74
1.43
3.1
2.5
514.4
703.7
e6/l
—
7
48
22
133
1.66
1.43
1.4
1.1
—
—
—
0
0
20
118
1.70
1.41
1.6
2.3
—
—
—
0
0
16
275
0.58
1.39
1.6
3.1
—
—
—
0
0
19
111
1.72
1.39
4.2
3.6
—
—
—
0
0
109
889
1.24
1.36
1.2
1.2
—
—
—
0
0
5
17
2.95
1.36
2.0
1.5
—
—
—
0
0
5
17
2.95
1.36
2.0
1.5
—
—
—
0
0
5
17
2.95
1.36
2.0
1.5
—
—
—
0
0
89
710
1.27
1.34
1.2
1.2
123.2
149.5
iu/ml
0.35
33
279
12
61
1.97
1.33
2.2
2.7
—
—
—
0
0
165
1408
1.19
1.32
1.7
1.6
—
—
—
0
0
33
225
1.48
1.32
1.5
1.6
—
—
—
0
0
214
1870
1.17
1.30
2.1
1.7
—
—
—
0
0
72
564
1.29
1.26
4.3
3.2
25.4
25.4
mmol/l
0.03
67
549
16
93
1.73
1.21
1.4
1.4
—
—
—
0
0
21
132
1.60
1.20
1.1
1.2
—
—
—
0
0
30
205
1.47
1.20
1.1
1.1
—
—
—
0
0
15
86
1.75
1.19
1.3
1.1
—
—
—
0
0
21
133
1.59
1.17
1.1
1.3
—
—
—
0
0
8
39
2.06
1.15
1.3
1.4
—
—
—
0
0
90
735
1.24
1.14
12.5
11.2
—
—
—
0
0
130
1107
1.19
1.10
2.0
2.3
6.5
7.9
ug/l
0.51
108
1001
17
104
1.64
1.09
1.2
1.2
—
—
—
0
0
115
969
1.20
1.09
3.3
2.9
219.9
176.5
ng/l
0.40
103
885
356
3274
1.11
1.02
3.6
3.1
—
—
—
0
0
366
3376
1.11
0.99
1.4
1.3
—
—
—
0
0
262
2372
1.13
0.98
4.1
3.8
312.9
476.0
ng/l
0.37
210
1862
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
55
435
1.27
0.95
1.1
1.1
—
—
—
0
0
23
158
1.46
0.94
1.7
1.6
58.4
61.9
%
0.20
16
100
12
70
1.72
0.92
7.1
6.9
—
—
—
0
0
20
134
1.50
0.92
1.6
1.5
23.2
29.2
%
0.42
13
86
52
412
1.27
0.90
4.6
3.4
0.3
0.2
g/l
0.35
22
181
5
105
0.47
0.88
29.2
18.5
1541.4
1505.7
nmol/l
—
5
105
8
44
1.82
0.86
1.1
1.3
—
—
—
0
0
77
642
1.21
0.85
1.1
1.1
—
—
—
0
0
13
80
1.63
0.84
1.1
1.0
—
—
—
0
0
6
31
1.94
0.84
1.0
1.1
—
—
—
0
0
6
31
1.94
0.84
1.5
1.1
—
—
—
0
0
15
96
1.57
0.84
6.5
5.6
51.5
58.8
u/ml
—
7
29
53
426
1.25
0.83
9.7
6.4
1.2
1.3
mmol/l
0.50
46
379
21
146
1.44
0.82
1.2
1.4
—
—
nmol/l
—
0
0
13
81
1.61
0.81
1.0
1.0
—
—
—
0
0
37
286
1.30
0.79
1.2
1.2
306.1
41.4
e6/l
0.41
29
219
37
286
1.30
0.79
1.2
1.3
42.8
1095.7
e6/l
1.33
31
224
22
156
1.42
0.79
1.2
1.4
—
—
—
0
0
12
74
1.63
0.78
5.7
4.1
—
—
—
0
0
7
122
0.57
0.78
1.7
1.5
0.9
1.0
g/l
—
7
122
144
1277
1.14
0.78
9.8
9.2
120.1
124.2
g/l
1.45
139
1233
99
855
1.17
0.76
9.1
7.4
24.5
24.6
mmol/l
0.08
93
803
32
244
1.32
0.75
1.1
1.6
—
—
—
0
0
23
313
0.73
0.75
1.4
1.3
156.8
216.7
miu/ml
—
8
135
14
91
1.54
0.75
1.9
1.7
7.3
6.9
mmol/l
—
8
57
34
262
1.30
0.75
2.8
2.2
138.0
130.3
g/l
1.17
27
188
13
83
1.57
0.75
1.4
1.9
—
—
—
0
0
79
671
1.19
0.74
1.3
1.3
—
—
—
0
0
5
24
2.09
0.74
1.0
1.3
—
—
—
0
0
7
38
1.85
0.73
2.7
2.0
—
—
—
0
0
15
100
1.50
0.73
1.1
1.1
233.9
293.6
mg/l
1.12
15
86
5
25
2.00
0.72
1.2
1.0
—
—
—
0
0
10
60
1.67
0.72
3.0
2.1
—
—
—
0
0
7
41
1.71
0.70
7.4
11.0
—
—
—
0
0
50
410
1.23
0.69
1.4
1.3
26.3
28.0
iu/l
0.10
38
346
18
127
1.42
0.68
2.6
1.3
—
—
—
0
0
18
127
1.42
0.68
3.1
2.5
1.2
1.2
e9/l
—
9
69
24
179
1.35
0.67
1.5
1.4
115.7
222.8
pmol/l
—
8
57
7
44
1.59
0.65
1.3
1.2
—
—
—
0
0
46
377
1.23
0.64
1.9
3.7
50.8
68.7
mg/l
0.45
38
299
46
377
1.23
0.64
1.9
3.7
30.7
41.3
mg/l
0.60
38
299
11
71
1.55
0.62
1.5
1.5
—
1871.2
—
0
16
120
1073
1.13
0.60
1.6
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
4.2
—
—
—
0
0
8
52
1.54
0.59
1.0
1.1
—
—
—
0
0
95
838
1.14
0.59
9.5
10.6
0.6
0.7
%
0.56
95
832
51
428
1.20
0.58
1.6
1.7
—
—
—
0
0
15
106
1.42
0.57
1.0
1.2
0.1
0.6
u/ml
—
6
54
12
81
1.49
0.57
1.2
1.2
—
—
—
0
0
101
898
1.13
0.57
7.1
5.1
—
—
—
0
0
166
1521
1.10
0.56
9.0
8.3
0.8
1.2
mmol/l
0.72
137
1211
6
37
1.62
0.55
15.5
6.7
—
—
—
0
0
6
39
1.54
0.53
3.2
2.3
—
—
—
0
0
10
66
1.52
0.52
2.1
2.8
731.8
1268.5
u/ml
—
10
66
120
1090
1.11
0.49
1.3
1.3
—
—
—
0
0
7
47
1.49
0.47
3.1
2.8
—
—
—
0
0
94
845
1.12
0.47
9.6
10.6
94.7
93.8
%
1.96
94
840
16
210
0.76
0.46
1.3
1.3
—
—
—
0
0
11
152
0.72
0.44
1.0
1.1
—
—
—
0
0
7
51
1.37
0.44
1.9
1.1
1173.9
1649.0
miu/ml
—
7
51
40
340
1.18
0.43
1.3
1.2
—
—
—
0
0
14
104
1.35
0.43
1.5
1.2
—
—
—
0
0
5
31
1.61
0.43
1.6
1.5
—
—
—
0
0
41
351
1.17
0.41
1.4
2.4
37.4
37.8
g/l
0.16
36
309
0
16
0.00
0.41
0.0
1.1
—
1.3
—
0
10
0
16
0.00
0.41
0.0
1.8
—
71.8
—
0
8
8
59
1.36
0.41
2.8
1.9
14.3
1.5
nmol/l
—
8
50
78
701
1.12
0.40
2.0
1.6
—
—
—
0
0
21
260
0.81
0.40
2.5
2.6
17.7
16.3
%
0.84
13
138
0
19
0.00
0.39
0.0
4.2
—
—
—
0
0
5
36
1.39
0.38
5.0
2.9
—
—
—
0
0
5
36
1.39
0.38
10.0
5.8
—
—
—
0
0
223
2110
1.07
0.38
3.3
3.0
2.4
2.4
mmol/l
0.55
201
1865
12
90
1.34
0.35
1.1
1.0
194.0
253.9
ng/l
—
7
57
6
42
1.43
0.35
3.3
3.0
—
—
—
0
0
34
292
1.17
0.34
2.0
3.8
—
—
—
0
0
27
227
1.19
0.34
3.3
2.8
—
—
—
0
0
21
172
1.22
0.34
1.3
1.2
—
—
—
0
0
12
91
1.32
0.33
1.1
1.1
—
—
—
0
0
12
91
1.32
0.33
1.1
1.0
702.7
737.4
ng/l
—
6
55
33
285
1.16
0.32
2.3
2.3
321.5
139.1
ug/min
0.33
21
177
132
1236
1.07
0.32
3.8
4.3
6.7
17.5
ug/l
1.37
104
1003
15
119
1.26
0.31
5.5
2.0
13.2
11.3
%
1.27
15
119
7
52
1.35
0.31
1.7
2.2
23.7
19.1
ug/l
—
7
43
23
272
0.84
0.30
1.7
1.4
—
—
—
0
0
11
84
1.31
0.30
4.2
2.6
0.3
0.2
e9/l
0.35
11
75
71
651
1.10
0.28
1.5
1.6
—
—
—
0
0
37
418
0.88
0.28
1.6
2.3
—
—
—
0
0
28
242
1.16
0.28
2.4
2.0
—
—
—
0
0
15
183
0.82
0.27
3.7
3.1
9.1
153.4
u/ml
0.92
15
178
25
215
1.17
0.26
6.2
3.5
—
—
—
0
0
5
72
0.69
0.26
1.0
1.2
199.8
148.0
nmol/l
—
5
72
23
198
1.16
0.24
1.7
1.5
—
—
—
0
0
25
217
1.15
0.24
1.2
1.4
—
—
—
0
0
16
133
1.21
0.24
1.3
2.4
—
—
—
0
0
37
331
1.12
0.24
5.6
4.7
7.4
7.4
ph
0.11
25
273
5
39
1.28
0.23
1.2
3.2
—
—
—
0
0
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
5
40
1.25
0.22
1.4
1.4
15.4
11.2
g/l
—
5
29
16
189
0.84
0.22
2.4
2.0
1.4
1.6
mmol/l
0.63
16
184
13
107
1.22
0.21
1.3
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
1.6
—
0
10
0
10
0.00
0.21
0.0
4.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
12.8
—
0
10
38
419
0.90
0.21
1.6
2.3
—
—
—
0
0
16
188
0.85
0.21
2.3
3.1
—
—
—
0
0
0
12
0.00
0.21
0.0
4.5
—
—
—
0
0
8
102
0.78
0.21
1.5
1.4
—
—
—
0
0
5
43
1.16
0.21
1.6
1.2
—
—
—
0
0
37
335
1.11
0.20
1.1
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
9
112
0.80
0.20
1.3
1.6
—
—
—
0
0
7
58
1.21
0.18
1.1
1.1
97.6
221.8
iu/ml
—
7
58
7
58
1.21
0.18
1.1
1.1
—
—
—
0
0
7
59
1.19
0.18
1.1
1.2
—
—
—
0
0
77
727
1.06
0.18
3.7
2.6
—
—
—
0
0
7
60
1.17
0.17
3.4
1.5
—
—
—
0
0
7
63
1.11
0.17
1.9
2.8
—
—
—
0
0
15
129
1.16
0.17
1.1
1.1
—
—
—
0
0
8
73
1.10
0.15
1.8
1.2
—
—
—
0
0
23
255
0.90
0.15
3.1
3.4
27.1
26.2
mg/l
0.05
16
152
9
81
1.11
0.15
1.3
1.4
—
—
—
0
0
9
81
1.11
0.15
1.3
1.3
—
—
—
0
0
39
420
0.93
0.15
1.7
2.3
—
—
—
0
0
15
131
1.15
0.14
1.0
1.2
—
—
—
0
0
10
85
1.18
0.12
1.4
1.4
—
—
—
0
0
153
1488
1.03
0.12
1.4
1.4
—
—
—
0
0
56
532
1.05
0.12
4.8
4.9
—
—
—
0
0
10
116
0.86
0.12
1.3
1.2
1.7
1.5
nmol/l
—
10
108
504
5102
0.98
0.11
2.7
2.7
—
—
—
0
0
17
153
1.11
0.11
2.2
2.2
31.5
32.9
pg
0.51
17
153
22
202
1.09
0.10
1.1
1.1
1.7
1.5
g/l
1.27
22
181
21
193
1.09
0.10
1.1
1.2
—
—
—
0
0
39
412
0.95
0.10
1.6
2.2
—
—
—
0
0
30
319
0.94
0.09
1.6
2.3
—
—
—
0
0
6
57
1.05
0.08
2.7
2.4
—
—
—
0
0
5
64
0.78
0.08
1.8
1.3
—
—
—
0
0
26
277
0.94
0.08
2.9
5.0
2.2
2.6
mmol/l
0.60
17
184
7
64
1.09
0.08
2.1
2.8
—
—
—
0
0
6
70
0.86
0.07
3.5
2.3
—
—
—
0
0
6
73
0.82
0.07
2.8
3.1
1301.7
1921.2
ml
—
6
64
6
74
0.81
0.07
1.2
1.4
—
—
—
0
0
6
75
0.80
0.07
2.7
2.2
467.7
512.3
min
—
6
54
94
916
1.03
0.07
1.6
1.5
—
—
—
0
0
50
481
1.04
0.07
4.2
4.3
1.4
1.3
mmol/l
0.22
50
472
83
808
1.03
0.07
1.3
1.2
—
—
—
0
0
46
478
0.96
0.07
1.7
1.6
—
—
—
0
0
8
90
0.89
0.06
1.1
1.2
—
—
—
0
0
37
385
0.96
0.05
1.5
2.4
—
—
—
0
0
102
1000
1.02
0.05
4.5
3.6
—
—
—
0
0
11
100
1.10
0.05
1.5
2.2
—
2.5
—
0
6
28
268
1.05
0.04
4.7
4.2
—
—
—
0
0
10
91
1.10
0.04
1.1
1.2
—
—
—
0
0
56
547
1.02
0.04
3.6
3.2
—
—
—
0
0
48
468
1.03
0.03
4.1
2.3
172.2
417.2
ug/l
1.64
42
442
32
311
1.03
0.02
4.5
2.9
23.1
24.8
mmol/l
1.41
27
279
20
208
0.96
0.02
1.1
1.1
—
—
—
0
0
12
113
1.06
0.02
1.2
1.1
285.5
281.2
mg/l
0.08
12
101
40
408
0.98
0.01
1.1
1.1
—
—
—
0
0
18
173
1.04
0.01
1.5
2.8
—
—
—
0
0
18
187
0.96
0.01
2.1
2.6
—
—
—
0
0
11
104
1.06
0.01
1.2
1.2
—
—
—
0
0
12
126
0.95
0.00
1.6
1.5
—
—
—
0
0
22
224
0.98
0.00
1.3
1.1
—
—
—
0
0
27
274
0.99
0.00
3.5
3.9
—
—
—
0
0
42
416
1.01
0.00
12.3
8.7
—
—
—
0
0
25
252
0.99
0.00
2.3
3.9
151.7
1209.4
u/ml
0.56
25
239
29
288
1.01
0.00
1.4
1.4
1.0
0.9
nmol/l
0.42
24
252
10
101
0.99
0.00
1.5
1.6
—
—
—
0
0
18
181
0.99
0.00
2.2
2.4
16468.4
1414.1
u/l
—
5
57
96
955
1.01
0.00
4.9
4.3
1.2
1.2
mmol/l
0.33
83
849
16
155
1.03
0.00
1.4
1.7
—
—
—
0
0
22
225
0.98
0.00
1.3
1.1
—
—
—
0
0
16
155
1.03
0.00
1.4
1.7
—
—
—
0
0
16
155
1.03
0.00
1.4
1.7
—
—
—
0
0
16
155
1.03
0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
7
76
0.92
0.00
11.6
11.0
0.6
0.6
mmol/l
—
7
71
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_RETINASEPAR and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETINASEPAR 0.841 [0.72, 0.98] 0.026
Birth year 0.995 [0.99, 1.0] 0.238

During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 3022 females with H7_RETINASEPAR died.

Males

Parameter HR [95% CI] p-value
H7_RETINASEPAR 0.78 [0.68, 0.89] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 454 out of 6289 males with H7_RETINASEPAR died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETINASEPAR.

N-year risk Females Males
1 0.074% 0.139%
5 0.577% 0.861%
10 1.373% 2.266%
15 2.356% 4.337%
20 4.263% 7.317%

Relationships between endpoints

Index endpoint: H7_RETINASEPAR – Separation of retinal layers (serosa)

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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