retinal detachment: An eye emergency condition which may lead to blindness if left untreated. It is characterized by the separation of the inner retina layers from the underlying pigment epithelium. Causes include trauma, advanced diabetes mellitus, high myopia, and choroid tumors. Symptoms include sudden appearance of floaters, sudden light flushes, and blurred vision.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1533 |
4. Check minimum number of eventsNone |
1533 |
5. Include endpointsNone |
1533 |
6. Filter based on genotype QC (FinnGen only) |
1533 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H35
- Name in latin
- Separatio stratorum retinae
Similar endpoints
↥List of similar endpoints to
Separation of retinal layers (serosa)
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 10471 | 3365 | 7063 |
Only index persons | 10254 | 3320 | 6934 |
Unadjusted period prevalence (%) | |||
Whole population | 0.16 | 0.10 | 0.20 |
Only index persons | 0.22 | 0.12 | 0.26 |
Median age at first event (years) | |||
Whole population | 49.96 | 56.13 | 47.11 |
Only index persons | 49.96 | 56.05 | 47.04 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 1533 | 576 | 957 |
Unadjusted period prevalence (%) | 0.34 | 0.20 | 0.42 |
Median age at first event (years) | 52.34 | 54.13 | 51.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1365
- Matched controls
- 13648
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINASEPAR and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_RETINASEPAR | 0.841 [0.72, 0.98] | 0.026 |
Birth year | 0.995 [0.99, 1.0] | 0.238 |
During the follow-up period (1.1.1998 — 31.12.2019), 301 out of 3022 females with H7_RETINASEPAR died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
H7_RETINASEPAR | 0.78 [0.68, 0.89] | < 0.001 |
Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 454 out of 6289 males with H7_RETINASEPAR died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINASEPAR.N-year risk | Females | Males |
---|---|---|
1 | 0.074% | 0.139% |
5 | 0.577% | 0.861% |
10 | 1.373% | 2.266% |
15 | 2.356% | 4.337% |
20 | 4.263% | 7.317% |
Relationships between endpoints
↥Index endpoint: H7_RETINASEPAR – Separation of retinal layers (serosa)
GWS hits: 3