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Disorders of pituitary gland, other and/or unspecified

DOID EFO Endpoint Browser PheWeb

E4_PITUDISNAS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E23.6, E23.7
  • Hospital discharge: ICD-9 — 253[8-9]
  • Hospital discharge: ICD-8 — 2539
  • Hospital discharge: excluded ICD-8 — 25390
  • Cause of death: ICD-10 — E23.6, E23.7
  • Cause of death: ICD-9 — 253[8-9]
  • Cause of death: ICD-8 — 2539
  • Cause of death: excluded ICD-8 — 25390

2 out of 7 registries used, show all original rules.

216

4. Check minimum number of events

None

216

5. Include endpoints

None

216

6. Filter based on genotype QC (FinnGen only)

212

Control definitions (FinnGen only)

Control exclude
E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1524 908 598
Only index persons 1235 751 484
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.02 0.03 0.02
Median age at first event (years)
Whole population 43.56 42.80 44.54
Only index persons 39.94 38.95 41.48

-FinnGen-

Key figures

All Female Male
Number of individuals 212 131 81
Unadjusted period prevalence (%) 0.04 0.05 0.04
Median age at first event (years) 43.06 41.15 46.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
216
Matched controls
2160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
114.9
153.8
80
11
E23.6
ICD-10 Finland
Other disorders of pituitary gland
+∞
119.1
103
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
63.8
58
*
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
58.0
53
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
710.1
57.4
54
*
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
+∞
56.8
52
*
E23.7
ICD-10 Finland
Disorder of pituitary gland, unspecified
+∞
54.5
50
*
H03AA01
ATC
levothyroxine sodium; systemic
6.8
44.4
114
306
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
11.5
33.1
37
38
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
376.9
32.8
32
*
102
Kela drug reimbursment
Diabetes insipidus
+∞
31.0
29
*
25398
ICD-8 Finland
Diseases of pituitary gland, Alii definiti
+∞
26.6
25
*
25399
ICD-8 Finland
Diseases of pituitary gland, Other and unspecified
+∞
26.6
25
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
+∞
24.4
23
*
E22.1
ICD-10 Finland
Hyperprolactinaemia
+∞
22.3
21
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
22.4
21.6
31
16
E23.2
ICD-10 Finland
Diabetes insipidus
+∞
21.2
20
*
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
+∞
18.0
17
*
N04BC06
ATC
cabergoline; oral
103.7
17.9
19
*
H01AC01
ATC
somatropin; parenteral
+∞
16.9
16
*
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
171.9
15.7
16
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
15.7
14.9
24
17
G02CB01
ATC
bromocriptine; systemic
18.2
13.3
20
12
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
12.6
12
*
301
Kela drug reimbursment
Growth hormone
+∞
12.6
12
*
XCK00
NOMESCO Finland
Perimetry
5.0
12.6
29
65
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.1
11.8
36
101
E23.05
ICD-10 Finland
Lack of TSH
+∞
11.6
11
*
ZXC86
NOMESCO Finland
Use of endoscopic device
115.4
10.5
11
*
E23.03
ICD-10 Finland
Lack of ACTH
+∞
10.5
10
*
2538X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Other disorders of the pituitary and other syndromes of diencephalohypophyseal origin[MORBUS HYPOPHYSEOS SEU HYPOTHALAMI ALIA]
+∞
9.4
9
*
E23
ICD-10 Finland
Hypofunction and other disorders of pituitary gland
+∞
9.4
9
*
121
Kela drug reimbursment
Severe hypofunction of sexual glands
11.4
8.4
15
14
E23.08
ICD-10 Finland
Hypopituitarism
+∞
8.4
8
*
25320
ICD-8 Finland
Diseases of pituitary gland, Chromophobe adenoma, pituitary
+∞
8.4
8
*
AA4CM
NOMESCO Finland
Extensive MRI examination of sella turcica with 3 Tesla magnet
+∞
8.4
8
*
E23.06
ICD-10 Finland
Empty sella
+∞
8.4
8
*
E23.01
ICD-10 Finland
Isolated deficiency of growth hormone
+∞
8.4
8
*
2532A
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Panhypopituitarism[PANHYPOPITUITARISMUS]
+∞
8.4
8
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
34.8
8.1
10
*
104
Kela drug reimbursment
Thyroid insufficiency
3.8
8.1
26
75
G02CB03
ATC
cabergoline; oral
82.8
7.5
8
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.6
7.4
18
42
AA4DG
NOMESCO Finland
Very extensive MRI examination of sella turcica with high intensity magnet
+∞
7.3
7
*
22620
ICD-8 Finland
Benign neoplasm of endocrine glands, Pituitary gland and craniopharyngeal duct (pouch)
+∞
7.3
7
*
2539X
ICD-9 Finland
Disorders of the pituitary gland and its hypothalamic control, Unspecified
+∞
7.3
7
*
E23.0
ICD-10 Finland
Hypopituitarism
+∞
7.3
7
*
D35.31
ICD-10 Finland
Cyst in Rathke's pocket
+∞
7.3
7
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
31.1
7.2
9
*
A02BC02
ATC
pantoprazole; systemic
2.3
7.0
157
1157
D35.30
ICD-10 Finland
Craniopharyngoma
+∞
6.3
6
*
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.2
103
665

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
112
151
14.33
87.59
5.7
1.9
294.65
390.77
nmol/l
4.17
105
139
44
14
39.21
69.20
1.5
1.2
—
—
—
0
0
45
44
12.66
41.89
2.0
1.2
4.57
7.82
u/l
1.12
33
34
51
95
6.72
27.72
2.7
3.2
4.10
4.65
pmol/l
2.28
45
85
43
78
6.63
23.81
1.7
1.2
24.30
25.55
iu/l
0.07
27
67
52
121
5.34
22.06
5.2
2.0
10.91
14.06
nmol/l
2.05
47
113
41
125
3.81
11.94
5.5
3.1
1.21
1.23
mmol/l
0.77
36
110
96
516
2.55
10.11
4.9
3.4
7.39
7.40
ph
0.82
31
92
133
839
2.52
9.83
6.6
5.8
29.30
28.30
%
0.45
128
782
132
832
2.51
9.74
5.9
5.6
56.93
56.90
%
0.01
127
777
123
751
2.48
9.72
12.0
5.6
1.22
1.21
mmol/l
0.15
114
691
129
813
2.46
9.40
12.7
6.5
1.22
1.21
mmol/l
0.40
99
689
69
326
2.64
9.38
4.2
2.8
495.53
533.31
mosm/kgh2o
0.79
58
277
128
813
2.41
9.03
6.6
5.8
2.53
2.81
%
0.88
121
755
38
132
3.28
8.99
4.9
4.0
—
—
—
0
0
128
817
2.39
8.88
6.7
6.1
8.76
8.40
%
0.40
123
760
124
787
2.35
8.63
6.7
5.8
0.64
0.66
%
0.18
119
726
135
902
2.32
8.15
6.1
5.7
1.94
1.96
e9/l
0.05
122
805
126
821
2.28
8.03
7.8
6.3
—
—
—
0
0
15
16
9.98
7.92
4.4
1.3
—
—
—
0
0
35
125
3.15
7.88
4.0
4.9
0.00
0.03
%
0.49
13
30
37
138
3.03
7.73
3.9
4.6
0.94
1.07
%
0.10
16
42
115
730
2.23
7.71
7.7
4.6
35.64
36.01
g/l
0.31
107
687
35
128
3.07
7.56
4.0
4.8
0.07
0.19
%
0.53
14
32
33
119
3.09
7.29
4.1
4.7
0.31
0.65
%
0.55
13
30
130
880
2.20
7.27
6.1
5.7
0.04
0.04
e9/l
0.03
114
766
175
1342
2.60
7.26
8.0
3.9
15.09
14.75
pmol/l
0.84
168
1224
18
30
6.44
7.25
2.8
1.3
0.80
0.46
g/l
0.58
12
25
13
13
10.55
7.14
1.8
1.3
—
—
—
0
0
118
776
2.15
7.02
14.5
9.1
0.00
0.00
e9/l
0.30
99
632
129
880
2.16
6.96
6.1
5.7
0.58
0.56
e9/l
0.52
113
765
18
46
4.18
6.58
1.3
1.3
58.33
3.10
e6/l
0.46
12
39
18
46
4.18
6.58
1.5
1.5
9.42
21.97
e6/l
0.61
12
39
13
16
8.57
6.43
2.2
1.6
33.08
31.75
pg
0.32
13
16
130
906
2.09
6.43
6.2
5.9
0.18
0.19
e9/l
0.26
114
806
18
36
5.36
6.35
1.4
1.3
—
—
—
0
0
112
750
2.02
6.06
9.2
12.8
1.15
1.23
inr
0.57
44
222
140
1025
2.04
5.79
8.9
9.3
3.96
4.04
e9/l
0.14
125
895
47
231
2.32
5.61
3.4
2.0
2.26
2.38
g/l
0.63
41
210
169
1354
2.14
5.11
8.9
7.3
75.71
78.44
u/l
0.38
164
1268
33
145
2.51
5.01
1.4
1.3
—
—
—
0
0
75
466
1.93
4.78
4.2
2.9
0.26
0.38
e6/l
0.45
59
349
10
14
7.43
4.71
1.4
1.0
—
—
—
0
0
10
14
7.43
4.71
1.5
1.3
—
—
nmol/l
—
0
0
45
236
2.15
4.55
1.2
1.2
—
—
—
0
0
189
1612
2.38
4.44
7.1
4.7
1.41
1.90
mu/l
6.81
175
1483
9
12
7.77
4.40
1.2
1.3
—
—
—
0
0
163
1323
1.95
4.27
4.7
4.0
11.98
11.26
mm/h
0.31
157
1218
13
30
4.54
4.20
3.8
1.8
16.20
16.53
%
—
6
10
42
221
2.12
4.20
3.4
2.1
19.22
22.77
%
1.08
36
190
11
21
5.46
4.20
6.5
1.6
—
—
—
0
0
10
17
6.11
4.18
1.5
1.2
—
—
—
0
0
10
17
6.11
4.18
2.8
1.6
—
—
—
0
0
68
426
1.87
4.15
6.4
4.4
—
—
—
0
0
74
477
1.84
4.12
4.6
3.2
—
—
—
0
0
78
519
1.79
3.88
4.3
3.0
27.03
154.64
e6/l
0.51
61
397
10
20
5.19
3.73
1.5
1.6
—
—
—
0
0
55
337
1.85
3.54
1.8
1.7
495.63
448.64
pmol/l
0.55
49
286
94
674
1.70
3.52
2.0
1.9
96.62
98.31
pmol/l
0.13
49
333
12
33
3.79
3.35
9.2
1.5
—
—
—
0
0
9
20
4.65
3.15
4.9
3.9
0.67
1.47
%
—
9
15
147
1207
1.68
3.13
5.8
4.3
—
—
—
0
0
60
391
1.74
3.12
1.4
1.7
0.79
1.19
mg/l
1.31
44
303
7
12
5.99
3.04
1.4
1.1
2.16
1.76
mmol/l
—
7
12
11
31
3.68
3.04
9.6
3.7
48.45
60.16
%
0.87
11
31
9
21
4.42
3.03
2.7
1.5
86.59
89.70
%
—
9
21
5
5
10.19
2.99
1.2
3.2
2190.00
2459.00
ml
—
5
5
68
464
1.68
2.98
4.3
2.8
—
—
—
0
0
8
17
4.84
2.95
1.6
1.1
243.25
267.71
pmol/l
—
8
17
53
341
1.73
2.86
3.8
2.4
5.83
4.84
e6/l
0.31
48
306
25
125
2.13
2.84
3.4
2.5
71.15
69.85
e9/l
0.06
20
91
40
240
1.82
2.73
2.9
2.1
—
—
—
0
0
111
869
1.57
2.72
4.9
3.6
0.00
0.00
estimate
-0.00
34
145
8
20
4.11
2.59
3.6
1.3
—
—
—
0
0
68
480
1.61
2.56
2.5
3.1
638.92
191.04
mg/l
0.31
45
299
10
31
3.33
2.55
1.2
1.2
—
—
—
0
0
10
31
3.33
2.55
8.0
3.1
4.10
4.95
e9/l
—
10
31
110
868
1.54
2.55
5.0
3.5
0.00
0.00
estimate
-0.00
34
163
109
861
1.54
2.50
7.1
4.8
0.00
0.00
estimate
-0.00
33
155
79
581
1.57
2.49
4.8
3.4
2.33
2.35
mmol/l
0.72
70
510
32
184
1.87
2.49
2.5
1.6
—
—
—
0
0
8
21
3.91
2.49
1.1
1.2
—
—
—
0
0
82
610
1.55
2.46
4.9
3.5
17.07
90.42
e6/l
0.98
62
429
7
17
4.22
2.38
2.3
3.0
—
—
—
0
0
13
53
2.55
2.32
2.2
1.6
—
—
—
0
0
58
405
1.59
2.26
1.3
1.2
0.92
1.00
u/ml
0.12
17
109
145
1235
1.53
2.23
4.0
3.6
—
—
—
0
0
6
14
4.38
2.16
1.3
1.1
—
—
—
0
0
14
62
2.35
2.12
1.1
2.2
1.69
1.50
g/l
0.25
14
52
38
242
1.69
2.11
1.4
1.4
280.00
454.07
titre
—
6
54
69
510
1.52
2.08
3.7
3.6
1.31
8.96
mg/mmol
4.29
47
317
44
293
1.63
2.07
1.7
1.6
1324.69
1162.86
nmol/l
0.50
35
212
32
196
1.74
2.04
1.2
1.4
—
—
—
0
0
182
1648
1.66
1.99
6.5
5.3
39.96
39.71
mmol/mol
0.13
175
1545
52
365
1.56
1.97
1.4
1.3
2.41
2.46
g/l
0.08
34
209
35
225
1.66
1.89
2.1
2.4
110.73
116.77
ug/g
0.08
26
180
70
532
1.47
1.81
2.3
2.1
—
—
—
0
0
40
269
1.60
1.81
3.4
2.9
3.33
2.59
e6/l
0.20
21
149
8
29
2.82
1.81
1.6
1.2
—
—
—
0
0
24
140
1.80
1.81
2.7
2.5
0.24
0.22
g/l
0.82
24
129
70
535
1.46
1.76
3.0
2.9
7.77
7.80
mmol/l
0.01
64
455
66
502
1.45
1.69
5.5
3.0
—
—
—
0
0
5
14
3.63
1.62
1.0
1.1
—
—
—
0
0
41
285
1.54
1.62
2.1
1.8
—
—
—
0
0
21
122
1.80
1.61
1.2
1.2
158.54
154.21
iu/ml
—
8
46
21
122
1.80
1.61
1.4
1.5
—
—
—
0
0
11
50
2.26
1.60
4.6
3.0
—
—
—
0
0
18
101
1.85
1.54
1.3
1.2
—
—
—
0
0
87
706
1.39
1.53
4.1
3.2
5.67
5.74
ph
—
6
72
30
196
1.62
1.53
1.5
1.6
—
—
—
0
0
7
27
2.64
1.53
1.1
1.3
—
—
—
0
0
6
21
2.91
1.51
4.5
1.8
—
—
—
0
0
6
21
2.91
1.51
2.7
2.9
—
—
—
0
0
61
467
1.43
1.50
5.0
3.8
0.00
0.00
estimate
-0.00
32
155
21
128
1.71
1.39
2.1
2.2
61.66
67.23
g/l
1.79
21
117
6
23
2.65
1.37
1.3
1.3
—
—
—
0
0
85
698
1.36
1.36
2.1
1.9
—
—
—
0
0
11
54
2.09
1.35
1.2
1.2
—
—
—
0
0
14
76
1.90
1.33
35.8
15.2
—
—
—
0
0
61
477
1.39
1.32
4.7
3.6
—
—
—
0
0
80
654
1.35
1.31
5.2
3.3
27.50
37.78
ng/l
0.63
55
432
18
108
1.73
1.27
1.1
1.2
—
—
—
0
0
57
445
1.38
1.24
6.8
7.1
—
—
—
0
0
43
321
1.42
1.21
4.6
2.8
2.42
2.45
mmol/l
1.08
38
283
29
200
1.52
1.20
7.1
6.0
106.17
103.92
mmol/l
1.34
29
200
55
432
1.37
1.15
2.2
2.5
362.38
4398.48
umol/l
1.52
45
365
12
205
0.56
1.13
1.5
1.3
—
—
—
0
0
13
73
1.83
1.13
1.2
1.2
—
—
—
0
0
7
31
2.30
1.11
5.7
1.6
25.09
24.11
mmol/l
—
7
31
20
130
1.59
1.07
10.2
7.0
—
—
—
0
0
5
22
2.30
1.04
3.6
6.3
—
—
—
0
0
189
1789
1.45
1.01
22.1
13.3
20.85
22.26
mg/l
0.25
168
1403
9
50
1.83
0.98
12.8
2.2
1.47
1.48
mg/l
—
9
43
30
219
1.43
0.96
2.7
2.6
5.83
7.47
umol/l
0.51
25
192
15
94
1.64
0.93
1.3
1.3
93.83
213.31
u/ml
1.11
15
83
6
30
2.03
0.87
17.8
1.9
8.08
8.19
kpa
—
6
30
22
154
1.48
0.87
1.1
1.2
—
—
—
0
0
22
155
1.47
0.85
27.4
10.4
96.63
96.23
%
0.24
22
149
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
41
327
1.31
0.78
4.1
3.5
51.46
227.58
ng/l
1.45
28
251
31
238
1.35
0.76
1.9
1.6
—
—
—
0
0
16
109
1.51
0.73
1.5
1.5
1.17
1.44
g/l
0.35
16
100
5
25
2.02
0.73
1.6
1.2
343.80
285.08
u/ml
—
5
12
29
222
1.35
0.73
2.2
1.4
—
—
—
0
0
9
57
1.60
0.72
11.1
3.0
—
—
—
0
0
5
30
1.68
0.62
2.4
1.8
3.64
133.62
u/ml
—
5
30
48
404
1.24
0.61
4.2
3.4
—
—
—
0
0
177
1692
1.26
0.60
4.5
3.8
1.43
1.29
mmol/l
1.65
169
1560
180
1724
1.26
0.60
5.1
4.4
5.79
5.91
mmol/l
0.83
171
1591
23
176
1.34
0.59
1.9
2.3
24.85
30.24
u/l
0.77
13
148
196
1901
1.34
0.55
13.4
10.0
31.40
26.53
u/l
0.50
191
1846
37
307
1.25
0.54
1.3
1.2
19.08
31.54
iu/ml
—
5
104
22
170
1.33
0.54
1.7
1.7
—
—
—
0
0
21
162
1.33
0.52
8.5
3.7
—
—
—
0
0
203
1982
1.40
0.51
31.7
19.2
39.74
40.45
%
0.74
193
1870
19
146
1.33
0.49
1.5
1.8
—
—
—
0
0
203
1984
1.39
0.48
32.0
19.3
258.63
252.38
e9/l
0.50
196
1945
7
48
1.47
0.47
7.3
4.9
—
—
—
0
0
203
1985
1.38
0.47
31.8
19.3
6.83
6.62
e9/l
0.91
196
1938
203
1985
1.38
0.47
31.8
19.3
4.48
4.52
e12/l
0.52
196
1937
133
1253
1.16
0.46
3.9
2.9
49.22
45.71
u/l
0.23
124
1184
15
112
1.36
0.46
1.5
2.0
—
—
—
0
0
24
193
1.27
0.46
1.3
1.2
—
—
—
0
0
7
50
1.41
0.45
67.3
15.1
1.06
1.18
mmol/l
—
7
43
74
669
1.16
0.44
3.7
2.7
—
—
—
0
0
13
96
1.38
0.42
5.1
3.5
—
—
—
0
0
0
16
0.00
0.41
0.0
15.0
—
780.81
—
0
16
0
16
0.00
0.41
0.0
2.9
—
—
—
0
0
0
16
0.00
0.41
0.0
18.2
—
1259.38
—
0
16
12
88
1.39
0.41
3.0
2.2
—
—
—
0
0
185
1796
1.21
0.40
5.3
4.8
2.69
2.80
mmol/l
0.95
179
1669
5
36
1.40
0.38
1.0
1.1
—
—
—
0
0
5
36
1.40
0.38
1.0
1.1
—
—
—
0
0
9
121
0.73
0.36
1.7
1.4
—
—
—
0
0
55
496
1.15
0.34
1.7
1.7
1.44
1.40
mmol/l
0.12
46
433
12
92
1.32
0.32
1.4
1.8
—
—
—
0
0
29
254
1.16
0.27
3.1
2.6
0.91
0.64
ug/l
0.54
20
149
11
86
1.29
0.26
1.0
1.1
—
—
—
0
0
10
78
1.30
0.24
1.7
2.0
—
—
—
0
0
5
39
1.29
0.23
12.8
2.8
—
—
—
0
0
180
1763
1.13
0.22
5.0
4.3
4.61
4.73
mmol/l
0.94
173
1648
0
11
0.00
0.21
0.0
3.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
7.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
190
1869
1.14
0.20
23.0
12.1
—
—
—
0
0
6
49
1.23
0.20
3.0
1.5
—
—
—
0
0
6
50
1.21
0.20
1.3
1.2
—
—
—
0
0
6
53
1.14
0.19
2.0
2.9
—
—
—
0
0
37
402
0.90
0.18
5.3
3.4
1.02
1.02
kg/l
—
6
52
7
60
1.17
0.18
4.4
1.6
1.56
5.67
ug/l
—
7
52
5
67
0.74
0.17
3.2
12.5
—
—
—
0
0
8
70
1.15
0.16
2.4
1.3
—
—
—
0
0
8
72
1.12
0.16
2.4
1.3
—
—
—
0
0
8
72
1.12
0.16
2.4
1.3
—
—
—
0
0
8
72
1.12
0.16
2.4
1.3
—
—
—
0
0
178
1751
1.09
0.16
4.8
4.3
1.39
1.48
mmol/l
2.63
173
1627
33
307
1.09
0.13
1.4
1.2
1.00
7.82
u/ml
2.64
13
133
12
104
1.16
0.12
40.6
8.5
—
—
—
0
0
12
105
1.15
0.11
41.8
11.2
23.99
24.61
mmol/l
0.37
12
100
21
193
1.10
0.10
1.2
1.4
—
—
—
0
0
7
65
1.08
0.08
1.3
1.1
—
—
—
0
0
7
66
1.06
0.08
4.9
3.6
—
—
—
0
0
7
66
1.06
0.08
67.0
12.3
1.30
1.57
%
—
7
61
12
132
0.90
0.07
5.8
3.9
—
—
—
0
0
19
179
1.07
0.05
4.6
4.0
232.09
7.93
ug/l
0.46
14
145
47
459
1.03
0.03
1.5
1.4
—
—
—
0
0
10
94
1.07
0.01
4.2
2.5
0.06
0.10
e6/l
—
10
88
12
124
0.97
0.00
1.4
1.4
—
—
—
0
0
13
134
0.97
0.00
4.5
3.1
—
—
—
0
0
13
125
1.04
0.00
3.2
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
5.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
75
0.93
-0.00
1.0
1.1
—
—
—
0
0
6
69
0.87
-0.00
2.8
1.3
—
—
—
0
0
8
88
0.91
-0.00
3.4
2.2
0.63
0.67
%
—
8
88
9
91
0.99
-0.00
4.3
2.2
1.61
1.29
%
—
9
91
6
59
1.02
-0.00
2.8
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
1.70
—
0
6
18
180
1.00
-0.00
1.6
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
2.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_PITUDISNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PITUDISNAS 2.384 [1.81, 3.14] < 0.001
Birth year 0.992 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 396 females with E4_PITUDISNAS died.

Males

Parameter HR [95% CI] p-value
E4_PITUDISNAS 1.387 [0.99, 1.95] 0.06
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 288 males with E4_PITUDISNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PITUDISNAS.

N-year risk Females Males
1 0.202% 0.217%
5 1.248% 1.664%
10 3.13% 4.363%
15 5.77% 8.112%
20 10.357% 13.946%

Relationships between endpoints

↥

Index endpoint: E4_PITUDISNAS – Disorders of pituitary gland, other and/or unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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