paralytic strabismus: An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them. [database_cross_reference: ORCID:0000-0003-0986-4123][database_cross_reference: ORCID:0000-0003-0986-4123]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
264 |
4. Check minimum number of eventsNone |
264 |
5. Include endpointsNone |
264 |
6. Filter based on genotype QC (FinnGen only) |
250 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other or unspecified paralytic strabismus
based on the number of shared cases.
Similar with more cases:
- Paralytic strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2784 | 1425 | 1332 |
| Only index persons | 1919 | 1005 | 914 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 47.92 | 50.73 | 44.72 |
| Only index persons | 40.99 | 43.75 | 37.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 250 | 130 | 120 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 44.64 | 42.47 | 46.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 264
- Matched controls
- 2640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
3785A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Paralytic strabismus
+∞
101.8
91
*
37304
ICD-8 Finland
Strabismus, paralyticus. Paresis nervorum III, IV, VI
+∞
97.0
87
*
H49.9
ICD-10 Finland
Paralytic strabismus, unspecified
+∞
62.0
57
*
H53.2
ICD-10 Finland
Diplopia
22.5
54.7
42
22
H49.8
ICD-10 Finland
Other paralytic strabismus
+∞
38.5
36
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
24.3
23
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
23.3
22
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.4
17.2
48
126
3503
FHL
Single muscle retroposition
+∞
16.8
16
*
H50.2
ICD-10 Finland
Vertical strabismus
136.2
12.5
13
*
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
11.5
11
*
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
10.5
10
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
9.4
9
*
3505
FHL
Single muscle resection
+∞
9.4
9
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
9.4
9
*
3507
FHL
Retroposition and resection
+∞
8.4
8
*
H02.4
ICD-10 Finland
Ptosis of eyelid
6.7
8.2
20
32
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.1
8.2
23
60
108
Kela drug reimbursment
Myasthenia gravis
82.3
7.5
8
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
7.3
7
*
H49.4
ICD-10 Finland
Progressive external ophthalmoplegia
+∞
7.3
7
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
7.3
7
*
XCK00
NOMESCO Finland
Perimetry
3.7
6.4
21
61
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
6.3
54
266
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
6.3
6
*
78110
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Diplopia
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
10
10
10.34
5.58
1.4
1.0
—
—
—
0
0
12
17
7.34
5.50
1.3
1.1
—
—
—
0
0
12
20
6.23
4.97
1.3
1.1
—
—
—
0
0
12
21
5.93
4.81
1.3
1.1
—
—
—
0
0
128
955
1.66
3.98
6.0
6.5
1.22
1.22
mmol/l
0.12
112
810
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
8
8.95
3.79
1.6
1.4
—
—
—
0
0
6
5
12.23
3.78
2.0
1.2
—
—
—
0
0
6
8
7.64
3.07
1.8
1.3
—
—
—
0
0
173
1446
1.57
3.00
4.1
3.8
15.21
14.76
pmol/l
1.62
162
1302
12
37
3.35
2.97
1.5
1.6
1.26
6.73
iu/l
—
5
9
6
9
6.79
2.88
2.8
1.3
—
—
—
0
0
114
884
1.51
2.71
6.0
5.5
1.21
1.22
mmol/l
0.16
104
802
5
7
7.25
2.56
1.2
1.0
—
—
—
0
0
5
7
7.25
2.56
1.2
1.0
—
—
—
0
0
15
63
2.46
2.51
1.1
2.5
9.03
10.03
g/l
0.69
15
56
0
61
0.00
2.27
0.0
1.6
—
—
—
0
0
39
244
1.70
2.26
5.9
7.0
103.64
103.70
mmol/l
0.03
39
244
52
352
1.59
2.23
1.7
1.7
1172.51
1207.32
nmol/l
0.10
39
272
5
9
5.64
2.22
1.0
1.0
—
—
—
0
0
15
69
2.24
2.09
1.1
2.5
3.46
3.37
g/l
0.16
15
63
15
69
2.24
2.09
1.1
2.5
7.34
7.23
g/l
0.09
15
63
15
69
2.24
2.09
1.1
2.5
—
—
—
0
0
13
57
2.35
2.01
1.0
2.6
40.50
39.52
g/l
0.44
13
51
35
223
1.66
1.91
4.6
4.6
1.00
1.02
mmol/l
0.32
35
202
24
138
1.81
1.87
7.2
5.9
7.77
9.55
mmol/l
0.62
24
130
113
924
1.39
1.85
17.7
14.0
1.22
1.29
inr
0.35
31
246
21
116
1.88
1.84
10.1
9.9
93.94
94.03
%
0.03
21
116
135
1143
1.37
1.76
6.1
4.7
6.52
6.77
mmol/l
0.92
127
1071
13
61
2.19
1.74
1.0
2.9
0.00
0.87
g/l
1.28
13
53
111
913
1.37
1.73
2.6
2.4
—
—
—
0
0
0
47
0.00
1.72
0.0
1.4
—
—
—
0
0
14
70
2.06
1.62
5.8
5.9
1.71
1.46
%
0.34
14
60
13
64
2.08
1.57
1.0
2.6
2.84
2.88
g/l
0.07
13
58
63
478
1.42
1.56
1.8
2.1
—
—
—
0
0
47
351
1.41
1.28
3.4
3.7
182.85
264.42
ng/l
0.17
40
273
6
25
2.43
1.25
1.2
1.4
—
—
—
0
0
147
1303
1.29
1.24
4.3
3.1
54.91
48.99
u/l
0.34
136
1217
127
1109
1.28
1.19
9.0
9.8
5.03
4.12
e9/l
0.87
107
970
10
50
2.04
1.18
1.6
1.4
—
—
—
0
0
7
31
2.29
1.11
2.4
2.8
101.43
106.29
mmol/l
—
7
31
5
21
2.41
1.09
1.0
1.7
14.35
14.27
ug/l
—
5
21
191
1773
1.28
1.00
5.5
4.5
1.97
1.92
mu/l
0.22
180
1606
67
550
1.29
1.00
3.0
2.9
0.30
0.51
e6/l
0.60
56
401
84
710
1.27
0.99
3.6
2.9
—
—
—
0
0
9
51
1.79
0.95
1.6
1.2
—
—
—
0
0
166
1521
1.25
0.95
8.9
7.6
83.52
78.70
u/l
0.62
154
1413
54
436
1.30
0.91
1.9
1.8
0.94
1.15
mg/l
0.42
38
337
91
786
1.24
0.89
2.1
1.9
98.84
95.00
pmol/l
0.31
51
399
8
43
1.89
0.88
1.1
1.3
—
—
—
0
0
8
43
1.89
0.88
1.1
1.3
—
—
—
0
0
51
415
1.28
0.82
1.7
1.7
430.33
439.81
pmol/l
0.12
42
349
10
58
1.75
0.81
1.7
1.4
—
—
—
0
0
12
74
1.65
0.79
1.2
2.0
0.80
1.79
ug/l
0.64
12
66
0
24
0.00
0.79
0.0
1.9
—
—
—
0
0
0
24
0.00
0.79
0.0
1.9
—
—
—
0
0
0
24
0.00
0.79
0.0
1.9
—
—
—
0
0
24
175
1.41
0.78
10.5
8.5
116.79
121.22
g/l
0.37
24
167
71
606
1.23
0.77
2.5
3.2
1165.19
1310.09
ng/l
0.15
64
531
75
646
1.22
0.74
3.3
3.3
2.37
2.35
mmol/l
0.39
65
567
90
790
1.21
0.74
2.2
2.2
76.89
75.80
nmol/l
0.14
81
701
30
230
1.34
0.73
1.3
1.8
—
—
—
0
0
16
109
1.50
0.73
1.3
1.2
309.26
155.91
iu/ml
—
5
45
35
276
1.31
0.71
2.4
1.9
2.33
2.36
g/l
0.09
30
252
5
26
1.94
0.71
1.0
1.3
—
—
—
0
0
5
27
1.87
0.69
2.0
1.9
—
—
—
0
0
5
27
1.87
0.69
1.0
1.1
—
—
—
0
0
42
342
1.27
0.68
2.4
2.5
2.14
1.04
e6/l
1.49
25
189
20
146
1.40
0.66
1.3
1.5
—
—
—
0
0
39
320
1.26
0.60
2.4
2.7
2.68
1.84
e6/l
0.49
22
172
0
21
0.00
0.60
0.0
1.3
—
271.40
—
0
21
6
37
1.64
0.56
2.3
1.4
—
111.88
—
0
8
27
214
1.29
0.55
9.7
7.7
5.00
5.07
kpa
0.16
27
201
27
214
1.29
0.55
9.7
7.7
12.12
12.01
kpa
0.04
27
202
15
108
1.41
0.54
1.4
1.3
—
—
—
0
0
9
64
1.42
0.52
1.0
1.7
—
—
—
0
0
87
785
1.16
0.51
4.3
3.8
34.52
33.87
ng/l
0.03
70
552
13
178
0.72
0.50
2.0
1.9
—
—
—
0
0
29
236
1.26
0.49
1.3
1.8
—
—
—
0
0
53
462
1.18
0.47
2.0
1.9
3.72
3.40
mg/l
0.24
47
394
67
597
1.16
0.46
4.1
3.6
10.00
9.19
mg/mmol
0.05
43
375
24
193
1.27
0.45
2.3
3.5
—
—
—
0
0
7
51
1.38
0.44
1.1
1.3
—
—
—
0
0
8
57
1.42
0.42
2.5
1.6
—
—
—
0
0
53
467
1.17
0.42
1.5
1.6
20.23
21.76
nmol/l
0.36
45
389
13
97
1.36
0.40
2.3
2.3
0.60
0.67
%
0.28
13
97
5
35
1.44
0.39
2.2
3.5
55.60
58.57
%
—
5
35
39
337
1.18
0.39
1.4
1.9
—
—
—
0
0
38
328
1.19
0.39
1.3
1.3
20.36
31.95
iu/ml
0.49
14
101
19
152
1.27
0.38
3.6
2.9
68.11
64.33
ml/min/173m2
—
9
61
9
70
1.30
0.37
2.3
1.8
—
—
—
0
0
10
73
1.38
0.35
1.3
1.9
—
—
—
0
0
7
53
1.33
0.31
1.4
1.7
—
—
—
0
0
22
260
0.83
0.31
1.7
1.4
—
—
—
0
0
39
347
1.15
0.29
4.1
2.9
2.45
2.46
mmol/l
0.21
32
307
45
405
1.13
0.28
1.2
1.2
0.67
1.63
u/ml
1.00
15
110
192
1868
1.10
0.26
4.1
3.9
1.33
1.32
mmol/l
0.13
178
1712
151
1455
1.09
0.25
4.1
4.0
13.58
11.91
mm/h
0.74
145
1339
9
76
1.19
0.25
2.9
2.4
—
—
—
0
0
6
82
0.73
0.24
3.8
3.2
19.17
2270.96
u/ml
—
6
68
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
5
38
1.32
0.23
1.8
1.3
316.00
275.52
u/ml
—
5
23
213
2088
1.10
0.22
20.4
16.5
76.66
77.04
umol/l
0.07
213
2088
5
40
1.25
0.22
1.8
1.3
—
—
—
0
0
13
156
0.82
0.22
1.6
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
5
43
1.17
0.21
1.4
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
51
1.18
0.19
1.3
1.1
—
—
—
0
0
6
51
1.18
0.19
1.3
1.2
—
—
—
0
0
6
53
1.14
0.19
1.0
1.3
—
10.04
—
0
11
11
132
0.83
0.18
3.2
2.7
282.82
172.85
ng/l
0.23
11
118
102
978
1.07
0.18
4.6
3.6
0.00
0.00
estimate
-0.00
20
190
12
100
1.21
0.18
10.4
6.8
25.82
24.61
mmol/l
0.52
12
100
104
998
1.07
0.18
4.6
3.6
0.00
0.00
estimate
-0.00
17
171
7
60
1.17
0.18
1.0
1.2
—
—
—
0
0
14
121
1.17
0.15
1.6
1.6
—
—
—
0
0
201
1978
1.07
0.14
5.3
4.8
2.67
2.75
mmol/l
0.62
188
1820
25
273
0.91
0.13
5.6
4.3
30.95
31.40
%
0.07
19
183
5
48
1.04
0.09
1.0
1.3
—
—
—
0
0
118
1205
0.96
0.09
2.7
3.0
—
—
—
0
0
189
1867
1.04
0.09
14.9
13.0
80.99
81.25
ml/min/173m2
0.06
164
1541
5
60
0.83
0.08
1.2
4.5
27.86
28.83
mg/l
—
5
46
5
60
0.83
0.08
1.2
4.5
45.50
64.69
mg/l
—
5
46
79
768
1.04
0.08
4.8
3.7
—
—
—
0
0
185
1828
1.04
0.08
6.6
5.6
39.94
40.18
mmol/mol
0.15
174
1697
196
1940
1.04
0.07
4.5
4.4
4.56
4.65
mmol/l
0.68
183
1793
26
245
1.07
0.07
6.7
7.8
—
—
—
0
0
7
84
0.83
0.07
1.3
2.1
—
—
—
0
0
8
94
0.85
0.07
1.1
1.0
—
—
—
0
0
36
345
1.05
0.06
1.6
1.5
—
—
—
0
0
15
162
0.92
0.06
1.7
1.7
—
—
—
0
0
69
673
1.03
0.06
4.4
4.9
2.33
2.53
ug/l
0.12
60
602
34
326
1.05
0.06
1.3
1.3
4.26
11.61
u/ml
0.93
14
118
52
532
0.97
0.03
3.9
4.5
23.12
20.37
%
0.47
22
249
194
1928
1.02
0.03
4.6
4.3
1.43
1.46
mmol/l
0.40
181
1774
210
2089
1.03
0.03
12.5
10.4
29.01
26.64
u/l
0.92
203
2016
41
400
1.03
0.03
3.1
3.0
0.55
0.72
ug/l
1.44
26
257
99
982
1.01
0.01
6.8
4.9
0.00
0.00
estimate
-0.00
17
180
217
2177
0.98
0.01
25.8
20.7
4.47
4.50
e12/l
0.31
210
2108
18
181
0.99
0.00
3.8
2.5
29.56
31.96
u/l
0.18
18
150
191
1914
0.99
0.00
4.7
4.5
6.02
6.03
mmol/l
0.02
176
1745
52
517
1.01
0.00
4.5
3.9
0.00
0.00
estimate
-0.00
16
172
217
2173
0.99
0.00
26.0
20.9
39.52
40.23
%
0.72
202
2051
217
2175
0.99
0.00
25.8
20.7
255.51
248.46
e9/l
0.93
210
2115
197
1973
0.99
0.00
19.0
14.2
24.74
23.99
mg/l
0.11
165
1550
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
5.5
—
221.50
—
0
8
0
8
0.00
0.00
0.0
7.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
20.46
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
72.84
—
0
9
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRANAS | 1.516 [1.09, 2.11] | 0.013 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 277 females with H7_PARASTRANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRANAS | 1.878 [1.32, 2.67] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 298 males with H7_PARASTRANAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.306% |
| 5 | 0.822% | 1.925% |
| 10 | 1.879% | 5.128% |
| 15 | 3.335% | 9.938% |
| 20 | 6.096% | 16.04% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRANAS – Other or unspecified paralytic strabismus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data