paralytic strabismus: An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them. [database_cross_reference: ORCID:0000-0003-0986-4123][database_cross_reference: ORCID:0000-0003-0986-4123]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
257 |
4. Check minimum number of eventsNone |
257 |
5. Include endpointsNone |
257 |
6. Filter based on genotype QC (FinnGen only) |
257 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other or unspecified paralytic strabismus
based on the number of shared cases.
Similar with more cases:
- Paralytic strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2784 | 1425 | 1332 |
| Only index persons | 1919 | 1005 | 914 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 47.92 | 50.73 | 44.72 |
| Only index persons | 40.99 | 43.75 | 37.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 257 | 132 | 125 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | 44.56 | 42.47 | 46.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 229
- Matched controls
- 2291
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
3785A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Paralytic strabismus
+∞
98.2
87
*
37304
ICD-8 Finland
Strabismus, paralyticus. Paresis nervorum III, IV, VI
+∞
81.2
73
*
H49.9
ICD-10 Finland
Paralytic strabismus, unspecified
+∞
46.5
43
*
H49.8
ICD-10 Finland
Other paralytic strabismus
+∞
34.2
32
*
H53.2
ICD-10 Finland
Diplopia
26.3
24.8
34
15
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
23.3
22
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
21.2
20
*
3503
FHL
Single muscle retroposition
+∞
15.8
15
*
H50.2
ICD-10 Finland
Vertical strabismus
+∞
11.6
11
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.7
11.0
38
92
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
10.5
10
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
9.4
9
*
3505
FHL
Single muscle resection
+∞
9.4
9
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
9.4
9
*
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
9.4
9
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.9
6.9
44
176
N07AA02
ATC
pyridostigmine; systemic
71.8
6.5
7
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.3
6.3
22
55
3507
FHL
Retroposition and resection
+∞
6.3
6
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
6.3
6
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
6.3
6
*
H49.4
ICD-10 Finland
Progressive external ophthalmoplegia
+∞
6.3
6
*
H02.4
ICD-10 Finland
Ptosis of eyelid
6.3
6.1
15
25
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRANAS | 1.516 [1.09, 2.11] | 0.013 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 277 females with H7_PARASTRANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRANAS | 1.878 [1.32, 2.67] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 298 males with H7_PARASTRANAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.306% |
| 5 | 0.822% | 1.925% |
| 10 | 1.879% | 5.128% |
| 15 | 3.335% | 9.938% |
| 20 | 6.096% | 16.04% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRANAS – Other or unspecified paralytic strabismus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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