paralytic strabismus: An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them. [database_cross_reference: ORCID:0000-0003-0986-4123][database_cross_reference: ORCID:0000-0003-0986-4123]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2526 |
4. Check minimum number of eventsNone |
2526 |
5. Include endpoints |
2677 |
6. Filter based on genotype QC (FinnGen only) |
2677 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H49-H52
- Name in latin
- Strabismus paralyticus
Similar endpoints
↥List of similar endpoints to
Paralytic strabismus
based on the number of shared cases.
Similar with more cases:
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18942 | 9349 | 9495 |
| Only index persons | 16522 | 8232 | 8290 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.27 | 0.27 |
| Only index persons | 0.31 | 0.30 | 0.32 |
| Median age at first event (years) | |||
| Whole population | 61.07 | 61.75 | 60.34 |
| Only index persons | 60.55 | 61.10 | 60.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2677 | 1333 | 1344 |
| Unadjusted period prevalence (%) | 0.52 | 0.45 | 0.59 |
| Median age at first event (years) | 60.35 | 57.13 | 63.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2427
- Matched controls
- 24271
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
323.0
1069
*
H53.2
ICD-10 Finland
Diplopia
66.6
323.0
898
212
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
3153.3
323.0
722
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
7254.0
323.0
572
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.6
190.6
490
785
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.6
190.1
636
1445
H50.2
ICD-10 Finland
Vertical strabismus
530.1
152.4
150
*
AA1AD
NOMESCO Finland
CT of head and brain
3.4
148.6
947
3813
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
110.2
105
*
XCK00
NOMESCO Finland
Perimetry
5.1
106.0
366
815
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.2
98.2
614
2305
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
965.1
95.6
93
*
3785A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Paralytic strabismus
+∞
91.2
87
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.4
90.2
360
923
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
82.8
79
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.7
80.9
196
272
37304
ICD-8 Finland
Strabismus, paralyticus. Paresis nervorum III, IV, VI
+∞
76.4
73
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
19.5
67.1
103
55
CE2W4
NOMESCO Finland
Eye movement mapping
141.9
65.2
69
5
TAB00
NOMESCO Finland
Lumbar puncture
5.2
62.8
206
424
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.1
51.0
309
1090
R51.80
ICD-10 Finland
Headache
2.5
47.7
414
1819
H49.9
ICD-10 Finland
Paralytic strabismus, unspecified
+∞
46.0
44
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.2
45.9
115
167
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.7
45.5
355
1463
G51.0
ICD-10 Finland
Bell palsy
5.9
44.9
131
234
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
43.9
42
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
435.1
43.3
43
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
41.8
40
*
G35
ICD-10 Finland
Multiple sclerosis
8.8
40.6
89
105
H50.52
ICD-10 Finland
Exophoria
89.6
39.9
44
5
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
11.5
39.7
75
67
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.9
38.0
250
924
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
8.4
37.5
84
103
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
6.2
37.4
103
171
H50.30
ICD-10 Finland
Intermittent esotropy
192.9
36.9
38
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.2
36.8
208
693
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.8
36.6
161
440
A10AE04
ATC
insulin glargine; parenteral
2.6
35.7
294
1239
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
35.2
984
6811
H02.4
ICD-10 Finland
Ptosis of eyelid
4.7
34.8
122
269
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
34.4
33
*
H49.8
ICD-10 Finland
Other paralytic strabismus
+∞
34.4
33
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
14.0
34.4
59
43
B01AC04
ATC
clopidogrel; oral
2.1
34.3
465
2490
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
8.6
34.0
75
90
109
Kela drug reimbursment
Multiple sclerosis
10.9
33.7
65
61
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
33.5
1081
7779
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.6
33.4
257
1042
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
11.6
32.6
61
54
XCK10
NOMESCO Finland
Photography of fundus of eye
2.4
31.6
306
1401
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
11.9
30.4
56
48
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
28.3
422
2329
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.7
27.6
205
811
H53.1
ICD-10 Finland
Subjective visual disturbances
2.8
27.1
180
667
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
5.7
27.1
79
142
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
26.8
229
982
H50.9
ICD-10 Finland
Strabismus, unspecified
273.9
26.8
27
*
H50.51
ICD-10 Finland
Esophoria
97.8
26.7
29
*
G70.0
ICD-10 Finland
Myasthenia gravis
14.9
26.5
44
30
A10AA02
ATC
NA
3.6
26.2
124
361
H50.31
ICD-10 Finland
Intermittent exotropia
+∞
26.1
25
*
R42
ICD-10 Finland
Dizziness and giddiness
1.8
25.4
535
3321
N07AA02
ATC
pyridostigmine; systemic
12.7
25.3
45
36
CS494
NOMESCO Finland
Other visual field testing
4.6
24.9
89
201
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.5
24.3
118
351
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
48.9
24.3
29
6
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
10.9
24.1
46
43
H49.4
ICD-10 Finland
Progressive external ophthalmoplegia
242.2
23.7
24
*
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
8.9
23.0
49
56
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.5
23.0
111
329
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
22.9
22
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.6
22.8
170
676
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
9.5
22.5
46
49
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.2
22.4
124
407
H50.8
ICD-10 Finland
Other specified strabismus
+∞
21.9
21
*
108
Kela drug reimbursment
Myasthenia gravis
16.1
21.9
35
22
H02.2
ICD-10 Finland
Lagophthalmos
17.2
21.8
34
20
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
21.7
665
4571
H52.1
ICD-10 Finland
Myopia
9.0
21.3
45
51
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.8
21.1
53
79
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.1
20.9
82
204
ZXD05
NOMESCO Finland
Urgent procedure
1.6
20.9
717
5067
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
4.0
20.8
84
214
H3603, E103
ICD-10 Finland
NA
7.4
20.7
49
67
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.5
20.6
164
676
3503
FHL
Single muscle retroposition
211.7
20.6
21
*
L03AB07
ATC
interferon beta-1a; parenteral
12.6
20.3
36
29
A10AA01
ATC
NA
3.7
20.0
88
242
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
+∞
19.8
19
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.9
19.6
82
216
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
19.6
569
3839
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.4
19.5
72
169
N02BE01
ATC
paracetamol; systemic, rectal
1.6
19.5
1980
17775
H3601, E113
ICD-10 Finland
NA
4.8
19.5
65
138
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.2
19.4
208
992
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
3.3
19.3
99
309
A10AE05
ATC
insulin detemir; parenteral
2.5
19.1
154
640
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
19.0
670
4741
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
5.5
18.9
56
104
H52.2
ICD-10 Finland
Astigmatism
12.8
18.9
33
26
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
9.6
18.8
38
40
PA7BD
NOMESCO Finland
CT angiography of neck and brain
4.0
18.7
75
191
T90.5
ICD-10 Finland
Sequelae of intracranial injury
5.9
18.6
52
90
H50.4
ICD-10 Finland
Other and unspecified heterotropia
191.4
18.6
19
*
ZXA10
NOMESCO Finland
Bilateral
1.7
18.5
435
2764
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
18.4
574
3937
C10AA01
ATC
simvastatin; oral
1.5
18.2
1035
8137
CEC80
NOMESCO Finland
Partial transposition of extraocular muscle
+∞
17.7
17
*
SPAT1301
SPAT
No procedures
1.5
17.7
741
5441
H46
ICD-10 Finland
Optic neuritis
8.6
17.7
38
45
T89
ICPC
Diabetes insulin dependent
3.0
17.2
100
341
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
17.1
371
2294
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
4.6
17.0
59
131
C08CA01
ATC
amlodipine; oral
1.5
17.0
830
6292
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
10.8
16.9
32
30
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
16.8
1348
11273
C10AA05
ATC
atorvastatin; oral
1.5
16.8
880
6767
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
6.5
16.7
43
67
F05
ICPC
Visual disturbance other
3.3
16.7
85
264
CKC12
NOMESCO Finland
Photocoagulation of retina
2.7
16.7
115
436
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
16.7
16
*
CEC20
NOMESCO Finland
Recession and advancement of extraocular muscle
+∞
16.7
16
*
S06.2
ICD-10 Finland
Diffuse brain injury
5.3
16.5
50
96
WX140
NOMESCO Finland
Parabulbar anesthesy
2.6
16.4
121
478
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
21.1
16.0
23
11
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
4.8
15.9
53
113
H47.1
ICD-10 Finland
Papilloedema, unspecified
10.1
15.9
31
31
N86
ICPC
Multiple sclerosis
9.5
15.9
32
34
H36.01
ICD-10 Finland
Diabetic maculopathy
4.9
15.9
52
109
XA800
NOMESCO Finland
Neuropsychological investigation
2.8
15.7
105
391
A28
ICPC
Limited function/disability NOS
1.7
15.6
365
2303
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
15.6
694
5139
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
2.6
15.6
116
462
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.2
15.5
82
263
J01DB01
ATC
cefalexin; oral
1.5
15.4
1823
16297
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.0
15.2
88
300
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
5.1
15.2
47
93
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3.8
15.1
63
167
H3601, E103
ICD-10 Finland
NA
6.0
15.1
41
69
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
5.5
15.1
44
81
H3603, E113
ICD-10 Finland
NA
5.2
14.8
45
87
Z3229
NOMESCO Finland
Other healthcare associate professional
1.9
14.6
213
1153
SPAT1229
SPAT
Assessment of need for aid
1.9
14.4
212
1153
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
5.6
14.3
41
74
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
14.2
389
2560
S06.3
ICD-10 Finland
Focal brain injury
4.3
14.2
52
123
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
14.1
792
6119
SPAT1262
SPAT
Handing over of treatment supplies
1.6
14.1
432
2928
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.0
14.0
56
144
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.2
13.9
73
234
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
7.8
13.8
31
40
N03AX16
ATC
pregabalin; oral
1.5
13.7
508
3596
H36.00
ICD-10 Finland
Diabetic background retinopathy
4.1
13.7
53
132
H47.2
ICD-10 Finland
Optic atrophy
9.7
13.7
27
28
SPAT1263
SPAT
Sampling
1.4
13.4
924
7393
H53.4
ICD-10 Finland
Visual field defects
3.4
13.4
65
197
AA1BD
NOMESCO Finland
Extensive CT of head and brain
2.9
13.3
82
291
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
5.6
13.3
38
69
H52.0
ICD-10 Finland
Hypermetropia
8.6
13.2
28
33
Z3231
NOMESCO Finland
Registered nurse
1.5
13.2
606
4487
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3.5
13.2
61
178
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.6
13.1
58
163
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
7.9
13.1
29
37
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
13.0
582
4284
L28
ICPC
Limited function/disability (L)
1.6
13.0
351
2301
H3602, E113
ICD-10 Finland
NA
16.8
13.0
20
12
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
13.0
325
2086
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.6
12.8
95
377
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
5.5
12.8
37
68
WX110
NOMESCO Finland
Local anesthesy
1.4
12.8
1456
12656
L04AX07
ATC
dimethyl fumarate; oral
11.6
12.8
23
20
S18
ICPC
Laceration/cut
1.4
12.8
917
7375
205
Kela drug reimbursment
Chronic hypertension
1.4
12.7
654
4946
G46.3*I67.9
ICD-10 Finland
Brain stem stroke syndrome (I60-I67+)
9.7
12.7
25
26
CKC15
NOMESCO Finland
Panretinal photocoagulation
5.3
12.7
38
73
N03AX12
ATC
gabapentin; oral
1.6
12.6
334
2173
T90
ICPC
Diabetes non-insulin dependent
1.5
12.6
517
3735
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.4
12.6
747
5803
ZXA05
NOMESCO Finland
Left side
1.5
12.6
559
4108
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
12.5
12
*
AAF00
NOMESCO Finland
Ventriculostomy
6.3
12.4
32
51
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
4.2
12.3
46
112
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
9.7
12.2
24
25
A10BA02
ATC
metformin; oral
1.4
12.0
625
4728
CKC10
NOMESCO Finland
Local photocoagulation of retina
3.4
12.0
56
165
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.8
12.0
226
1334
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
11.9
626
4747
A10BB01
ATC
glibenclamide; oral
2.2
11.9
118
545
G71.3
ICD-10 Finland
Mitochondrial myopathy, not elsewhere classified
46.9
11.9
14
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
14.7
11.8
19
13
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.9
11.8
166
889
A02BC02
ATC
pantoprazole; systemic
1.4
11.8
1409
12263
L04AX01
ATC
azathioprine; systemic
2.4
11.7
98
418
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.9
11.6
161
857
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
5.8
11.6
32
56
G52.8
ICD-10 Finland
Disorders of other specified cranial nerves
65.2
11.6
13
*
353
Kela drug reimbursment
Cladribine and fingolimod
19.0
11.6
17
9
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
11.5
451
3217
SPAT1153
SPAT
Removal of sutures
1.4
11.5
716
5593
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.1
11.5
125
603
H51.9
ICD-10 Finland
Disorder of binocular movement, unspecified
+∞
11.5
11
*
3507
FHL
Retroposition and resection
+∞
11.5
11
*
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
+∞
11.5
11
*
177
Kela drug reimbursment
Insulin glargine 300 U / ml
3.3
11.4
55
167
H02AB09
ATC
hydrocortisone; systemic
3.2
11.4
59
189
H04AA01
ATC
glucagon; nasal, parenteral
3.3
11.1
55
171
L03AX13
ATC
glatiramer acetate; parenteral
10.1
11.0
21
21
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
10.1
11.0
21
21
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
11.0
193
1116
R53
ICD-10 Finland
Malaise and fatigue
1.5
10.9
428
3049
H25.1
ICD-10 Finland
Senile nuclear cataract
1.4
10.9
558
4198
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.0
10.9
60
201
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.1
10.8
125
618
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
12.0
10.8
19
16
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
10.7
644
4983
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
5.2
10.7
32
62
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.9
10.7
163
896
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.8
10.7
172
964
H26.4
ICD-10 Finland
After-cataract
1.7
10.6
210
1258
K90
ICPC
Stroke/cerebrovascular accident
2.6
10.5
75
295
164
Kela drug reimbursment
Fingolimod
14.3
10.5
17
12
UJF32
NOMESCO Finland
Coloscopy
1.4
10.5
551
4163
H51.8
ICD-10 Finland
Other specified disorders of binocular movement
+∞
10.4
10
*
H49.3
ICD-10 Finland
Total (external) ophthalmoplegia
+∞
10.4
10
*
3505
FHL
Single muscle resection
+∞
10.4
10
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
5.4
10.4
30
56
A10AE06
ATC
insulin degludec; parenteral
2.7
10.2
68
254
H16.0
ICD-10 Finland
Corneal ulcer
2.2
10.2
100
462
N06AX11
ATC
mirtazapine; oral
1.4
10.2
635
4941
H43.1
ICD-10 Finland
Vitreous haemorrhage
2.8
10.1
63
226
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.5
10.1
79
326
C09AA05
ATC
ramipril; oral
1.4
10.1
558
4252
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
6.9
10.1
24
35
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.7
10.0
191
1134
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
2.4
10.0
85
368
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.5
10.0
428
3103
CBJ10
NOMESCO Finland
Fascia plate sling or synthetic material for ptosis correction
40.2
10.0
12
*
H53.8
ICD-10 Finland
Other visual disturbances
4.8
9.9
32
68
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
4.0
9.9
38
96
G91.1
ICD-10 Finland
Obstructive hydrocephalus
6.7
9.9
24
36
H53.0
ICD-10 Finland
Amblyopia ex anopsia
6.3
9.8
25
40
G91.0
ICD-10 Finland
Communicating hydrocephalus
6.0
9.8
26
44
N18
ICPC
Paralysis/weakness
3.0
9.8
54
182
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
9.6
9.8
19
20
H57.1
ICD-10 Finland
Ocular pain
2.7
9.7
66
252
N29
ICPC
Neurological sympt/complt other
3.0
9.7
53
177
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
9.7
452
3331
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.5
9.7
371
2630
L04AA31
ATC
teriflunomide; oral
13.4
9.7
16
12
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.7
9.6
184
1091
E23.00
ICD-10 Finland
Panhypopituitarism
6.8
9.6
23
34
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
11.4
9.6
17
15
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
9.4
681
5418
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.6
9.4
239
1537
XCW11
NOMESCO Finland
Assessment of strabismus
100.4
9.4
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
9.4
439
3234
S04.1
ICD-10 Finland
Injury of oculomotor nerve
+∞
9.4
9
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
9.4
276
1843
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
3.4
9.4
43
127
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
5.3
9.4
27
51
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
9.3
896
7447
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
9.3
294
1997
E10
ICD-10 Finland
Type 1 diabetes mellitus
3.1
9.3
48
155
A06AD11
ATC
lactulose; oral
1.5
9.3
315
2172
G44.2
ICD-10 Finland
Tension-type headache
1.6
9.3
248
1617
H3600, E113
ICD-10 Finland
NA
3.5
9.3
42
123
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.6
9.2
274
1831
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
9.2
182
1093
H3600, E103
ICD-10 Finland
NA
4.2
9.2
33
79
WX882
NOMESCO Finland
High dependency care
2.5
9.2
70
287
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.5
9.1
67
269
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
9.1
337
2368
N06AB10
ATC
escitalopram; oral
1.5
9.1
357
2543
Z2446
NOMESCO Finland
Social worker
1.9
9.1
130
700
N02AA05
ATC
oxycodone; systemic
1.5
9.0
322
2247
C03CA01
ATC
furosemide; systemic
1.4
9.0
648
5146
SPAT1216
SPAT
Assessment of functional ability
1.5
8.9
340
2403
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
8.9
351
2501
N03AX14
ATC
levetiracetam; systemic
2.6
8.9
64
252
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
8.9
831
6863
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
5.8
8.9
24
42
SPAT1260
SPAT
Consultation of another employee
1.5
8.9
377
2727
A10BB12
ATC
glimepiride; oral
1.7
8.8
172
1027
D32.01
ICD-10 Finland
Benign tumor of meninges on interhemispheric surface
8.6
8.8
18
21
H02AB06
ATC
prednisolone; systemic
1.3
8.8
976
8258
C09AA02
ATC
enalapril; systemic
1.4
8.8
432
3214
SPAT1234
SPAT
Support of social functional capacity
2.0
8.7
114
596
101
Kela drug reimbursment
Anterior pituitary hypofunction
5.6
8.7
24
43
ZXA00
NOMESCO Finland
Right side
1.4
8.7
569
4444
L03AB08
ATC
interferon beta-1b; parenteral
14.1
8.7
14
10
H52.5
ICD-10 Finland
Disorders of accommodation
50.2
8.7
10
*
G52.9
ICD-10 Finland
Cranial nerve disorder, unspecified
50.2
8.7
10
*
RS221
NOMESCO Finland
NA
3.5
8.6
38
109
ZXC95
NOMESCO Finland
Use of surgical navigator
3.9
8.6
34
89
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
3.2
8.6
43
136
CBH25
NOMESCO Finland
Tarsorrhaphy
16.3
8.5
13
8
C09CA01
ATC
losartan; oral
1.4
8.5
501
3845
CBK11
NOMESCO Finland
Operation for lagophtalmus with implant
27.6
8.5
11
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
8.4
280
1921
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
8.4
280
1923
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
5.7
8.4
23
41
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
8.4
322
2280
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
8.3
8
*
3783A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Other and unspecified heterotropia
+∞
8.3
8
*
37302
ICD-8 Finland
Strabismus, Concomitans sursum sive deorsum vergens
+∞
8.3
8
*
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
1.8
8.3
128
711
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
10.8
8.3
15
14
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
10.8
8.3
15
14
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
5.5
8.3
23
42
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.7
8.3
175
1071
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
9.5
8.3
16
17
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
3.3
8.3
40
124
S02.11
ICD-10 Finland
Fracture of base of skull, open
7.1
8.2
19
27
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
8.2
793
6560
L04AA27
ATC
fingolimod; oral
14.5
8.2
13
9
K91
ICPC
Cerebrovascular disease
3.4
8.2
37
109
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
2.6
8.1
57
224
N03AF01
ATC
carbamazepine; oral, rectal
1.9
8.1
112
597
Q28.3
ICD-10 Finland
Other malformations of cerebral vessels
6.8
8.1
19
28
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
4.8
8.1
25
52
ZX120
NOMESCO Finland
Intravenous
1.6
8.0
195
1240
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.3
8.0
595
4739
SPAT1312
SPAT
General health counselling
1.3
8.0
651
5255
N06AX16
ATC
venlafaxine; oral
1.5
8.0
237
1584
S06.0
ICD-10 Finland
Concussion
1.6
8.0
204
1316
S02.10
ICD-10 Finland
Fracture of base of skull, closed
7.2
8.0
18
25
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.4
7.9
504
3912
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
2.7
7.9
51
190
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
7.9
729
5986
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.0
7.8
96
491
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.6
7.8
188
1193
H50.59
ICD-10 Finland
Heterophor UNS
45.1
7.7
9
*
K08.3
ICD-10 Finland
Retained dental root
1.8
7.7
139
811
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.6
7.7
51
195
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
5.6
7.7
21
38
G91.8
ICD-10 Finland
Other hydrocephalus
18.4
7.6
11
6
D33.39
ICD-10 Finland
Benign tumor of the cranial nerves UNS
25.1
7.6
10
*
N03AF02
ATC
oxcarbazepine; oral
2.2
7.6
69
312
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
7.6
289
2042
N28
ICPC
Limited function/disability (N)
3.0
7.6
40
133
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
4.0
7.6
28
70
D43.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Central nervous system, unspecified
8.9
7.5
15
17
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
10.0
7.5
14
14
K59.09
ICD-10 Finland
Constipation, unspecified
1.8
7.5
123
697
N01
ICPC
Headache
1.7
7.5
166
1031
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
7.5
351
2581
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
7.1
7.5
17
24
G04BD09
ATC
trospium; oral
2.4
7.5
59
248
I63.8
ICD-10 Finland
Other cerebral infarction
4.0
7.5
28
71
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
3.1
7.4
39
129
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.0
7.4
95
493
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.6
7.4
192
1243
PA6AD
NOMESCO Finland
CT of neck arteries
3.2
7.4
36
113
N18.8
ICD-10 Finland
Other chronic renal failure
2.3
7.3
64
283
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.6
7.3
191
1239
B01AC07
ATC
dipyridamole; systemic
1.9
7.3
110
607
H51.1
ICD-10 Finland
Convergence insufficiency and excess
+∞
7.3
7
*
9530/0-C70.9
ICD-O-3
Meningioma, NOS, of meninges, NOS
9.4
7.3
14
15
L01
ICPC
Neck symptom/complaint
1.5
7.2
250
1730
J01DA01
ATC
[U] cefalexin; systemic
1.3
7.2
1305
11645
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
2.3
7.2
60
260
A10BH01
ATC
sitagliptin; oral
1.6
7.1
198
1301
J01FF01
ATC
clindamycin; systemic
1.3
7.1
530
4210
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
7.1
659
5404
WX002
NOMESCO Finland
Sedation and analgesia
1.4
7.1
393
2977
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
4.0
7.1
26
65
P20
ICPC
Memory disturbance
1.5
7.1
262
1842
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.5
7.0
248
1725
SPAT1310
SPAT
Counselling related to known health issue
1.3
7.0
650
5327
SPAT1215
SPAT
Assessment of need for medical rehabilitation
1.9
7.0
90
470
R13
ICD-10 Finland
Dysphagia
1.7
7.0
136
814
S02.30
ICD-10 Finland
Fracture of orbital floor, closed
4.1
7.0
25
61
R4150
NOMESCO Finland
Neuropsychological rehabilitation
4.9
7.0
21
43
M79.6
ICD-10 Finland
Pain in limb
1.3
6.9
685
5662
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.1
6.9
76
371
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.5
6.9
218
1476
XX3DW
NOMESCO Finland
Time consuming IT work
1.5
6.9
205
1371
C01DA14
ATC
isosorbide mononitrate; oral
1.4
6.9
341
2531
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
5.2
6.9
20
39
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
6.9
793
6684
ZXE30
NOMESCO Finland
More than five and less than seven hours
1.8
6.9
109
613
H57.0
ICD-10 Finland
Anomalies of pupillary function
5.8
6.9
18
31
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
13.8
6.9
11
8
N05CF01
ATC
zopiclone; oral
1.3
6.8
658
5417
G47.3
ICD-10 Finland
Sleep apnoea
1.4
6.8
397
3033
K02.1
ICD-10 Finland
Caries of dentine
1.3
6.8
1083
9494
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
1.8
6.8
106
593
R56.8
ICD-10 Finland
Other and unspecified convulsions
1.9
6.8
98
533
R11
ICD-10 Finland
Nausea and vomiting
1.6
6.8
154
964
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
2.4
6.8
52
217
H50.50
ICD-10 Finland
Alternating hyperphoria
40.2
6.8
8
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
6.8
299
2177
H25.8
ICD-10 Finland
Other senile cataract
1.5
6.7
227
1562
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
3.2
6.7
32
100
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
3.2
6.7
32
100
V03AE01
ATC
polystyrene sulfonate; oral
3.2
6.7
32
100
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
1.5
6.7
203
1365
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
6.4
6.6
16
25
H25.0
ICD-10 Finland
Senile incipient cataract
1.7
6.6
124
734
N06AA09
ATC
amitriptyline; systemic
1.5
6.6
191
1271
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
3.4
6.6
29
85
W19
ICD-10 Finland
Unspecified fall
1.6
6.6
183
1204
L76
ICPC
Fracture: other
2.3
6.6
57
253
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
3.3
6.6
31
96
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.2
6.6
61
277
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
2.6
6.6
44
171
GEC24
NOMESCO Finland
Thoracoscopic thymectomy
8.7
6.5
13
15
D33.30
ICD-10 Finland
Acoustic neuroma
4.1
6.5
23
56
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
3.6
6.5
27
76
NHQ40
NOMESCO Finland
Amputation of toe
2.7
6.5
42
159
TCE00
NOMESCO Finland
Therapeutic injection into extraocular muscle
70.0
6.4
7
*
D33.11
ICD-10 Finland
Brain stem
70.0
6.4
7
*
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
7.4
6.4
14
19
ZXE20
NOMESCO Finland
More than three and less than five hours
1.4
6.4
275
1994
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
6.3
211
1451
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
6.3
233
1635
WX872
NOMESCO Finland
Intensive care
1.8
6.3
107
617
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.0
6.3
74
376
D32.07
ICD-10 Finland
Secondary or multiple benign tumor of the meninges below the exam
18.1
6.3
9
5
CEC85
NOMESCO Finland
Combined correction of cyclodeviation
+∞
6.3
6
*
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
+∞
6.3
6
*
D33.37
ICD-10 Finland
Another benign tumor of the cranial nerves
26.7
6.2
8
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
4.8
6.2
19
40
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.2
531
4295
G04CA02
ATC
tamsulosin; oral
1.3
6.2
500
4010
M03BX01
ATC
baclofen; systemic
2.8
6.2
36
128
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
5.0
6.2
18
36
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
6.2
675
5640
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
6.3
6.2
15
24
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
2.4
6.1
47
195
N03AG01
ATC
valproic acid; systemic, rectal
1.8
6.1
106
616
AA5PD
NOMESCO Finland
CT examination of brain pefusion
4.0
6.1
22
55
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
2.7
6.1
38
143
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
6.7
6.0
14
21
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRAB and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRAB | 1.349 [1.22, 1.49] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 1840 out of 7311 females with H7_PARASTRAB died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRAB | 1.428 [1.29, 1.58] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 2050 out of 7503 males with H7_PARASTRAB died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRAB.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.105% | 0.282% |
| 5 | 0.75% | 1.616% |
| 10 | 1.723% | 4.105% |
| 15 | 3.265% | 8.143% |
| 20 | 5.54% | 13.415% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRAB – Paralytic strabismus
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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