Risteys · H7_PARASTRA6

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H49.2 Cause of death: ICD-10 — H49.2 2 out of 7 registries used, show all original rules.	1181
4. Check minimum number of events None	1181
5. Include endpoints None	1181
6. Filter based on genotype QC (FinnGen only)	1181

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	7973	4049	3894
Only index persons	7178	3707	3471
Unadjusted period prevalence (%)
Whole population	0.11	0.12	0.11
Only index persons	0.13	0.14	0.13
Median age at first event (years)
Whole population	63.91	64.87	62.88
Only index persons	63.69	64.69	62.63

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	1181	574	607
Unadjusted period prevalence (%)	0.23	0.20	0.27
Median age at first event (years)	62.57	60.31	64.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1068: Matched controls
10680

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H53.2

ICD-10 Finland

Diplopia

73.2

323.0

460

109

H49.2

ICD-10 Finland

Sixth [abducent] nerve palsy

+∞

323.0

1068

XCW99

NOMESCO Finland

Other investigative procedure of eye

6.0

93.1

291

623

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

7.3

86.0

226

379

H49.0

ICD-10 Finland

Third [oculomotor] nerve palsy

+∞

69.5

AA1AD

NOMESCO Finland

CT of head and brain

3.4

65.9

423

1722

H50.0

ICD-10 Finland

Convergent concomitant strabismus

+∞

65.3

CEC10

NOMESCO Finland

Recession and resection of extraocular muscle

+∞

55.7

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

11.5

55.2

106

101

H49.1

ICD-10 Finland

Fourth [trochlear] nerve palsy

554.8

54.0

XCK00

NOMESCO Finland

Perimetry

5.5

51.4

163

336

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.3

45.7

274

1012

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

4.2

37.0

154

416

CE2W4

NOMESCO Finland

Eye movement mapping

191.4

36.0

A10AE04

ATC

insulin glargine; parenteral

3.7

35.7

171

522

D32.02

ICD-10 Finland

Benign tumor of the meninges at the base of the brain

19.1

33.4

G51.0

ICD-10 Finland

Bell palsy

7.5

32.2

111

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

3.8

30.4

140

411

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

3.6

29.5

145

449

G35

ICD-10 Finland

Multiple sclerosis

11.5

29.3

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

8.7

28.9

TAB00

NOMESCO Finland

Lumbar puncture

5.3

27.9

177

CEC00

NOMESCO Finland

Recession of extraocular muscle

+∞

27.2

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

3.3

27.0

145

479

H50.30

ICD-10 Finland

Intermittent esotropy

277.7

26.8

303

Kela drug reimbursment

Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)

19.2

25.8

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

2.9

25.0

170

658

109

Kela drug reimbursment

Multiple sclerosis

14.5

25.0

103

Kela drug reimbursment

Diabetes, insulin-treated

2.1

23.8

343

1957

157

Kela drug reimbursment

Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)

17.7

23.2

AAB10

NOMESCO Finland

Partial excision of intracranial lesion

14.5

22.7

XCK10

NOMESCO Finland

Photography of fundus of eye

2.7

22.0

160

644

CEW99

NOMESCO Finland

Other operation on extraocular muscle

+∞

21.9

CA1CG

NOMESCO Finland

Eye and orbita extensive MRI examination with high intensity magnet

18.9

21.8

A10AA02

ATC

4.6

20.8

170

215

Kela drug reimbursment

Diabetes, non-insulin-treated

2.1

20.8

301

1705

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

3.4

20.7

107

342

B01AC04

ATC

clopidogrel; oral

2.3

20.5

227

1141

R51.80

ICD-10 Finland

Headache

2.4

18.6

173

792

E10.9

ICD-10 Finland

Type 1 diabetes mellitus, Without complications

4.4

18.6

166

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

2.0

18.4

291

1693

25000

ICD-8 Finland

Diabetes mellitus, Sine complicatione

5.5

18.0

103

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

3.3

17.9

293

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

5.9

17.4

A10AB01

ATC

insulin (human); parenteral (insulins and analog. for injection, fast-acting)

4.3

17.1

160

CEC30

NOMESCO Finland

Resection of extraocular muscle

+∞

16.7

H50.51

ICD-10 Finland

Esophoria

172.5

16.5

H02.2

ICD-10 Finland

Lagophthalmos

23.5

16.5

T89

ICPC

Diabetes insulin dependent

4.2

16.1

155

PA7AD

NOMESCO Finland

CT angiography of head and neck vasculature

5.5

15.9

H50.2

ICD-10 Finland

Vertical strabismus

86.4

15.6

G37.9

ICD-10 Finland

Demyelinating disease of central nervous system, unspecified

19.5

15.6

E10.3

ICD-10 Finland

Type 1 diabetes mellitus, With ophthalmic complications

5.4

15.6

A10AE05

ATC

insulin detemir; parenteral

3.2

15.5

278

A10AA01

ATC

4.7

15.5

118

C10AA05

ATC

atorvastatin; oral

1.7

15.5

435

3038

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

6.8

14.9

H3601, E113

ICD-10 Finland

7.6

14.8

CEC60

NOMESCO Finland

Transposition of extraocular muscle with adjustable suture

+∞

14.6

H46

ICD-10 Finland

Optic neuritis

12.8

14.4

D32.00

ICD-10 Finland

Benign tumor of the meninges on the outer surface of the cerebrum

7.5

14.3

A10BA02

ATC

metformin; oral

1.8

14.2

317

2049

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.7

14.2

486

3563

CS444

NOMESCO Finland

Visual field testing with Octopus automated perimetry

4.4

14.2

120

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.7

14.1

429

3043

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

2.7

13.9

372

PA7BD

NOMESCO Finland

CT angiography of neck and brain

6.1

13.9

C08CA01

ATC

amlodipine; oral

1.7

13.7

399

2786

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

3.4

13.7

201

H36.01

ICD-10 Finland

Diabetic maculopathy

8.5

13.6

L03AB07

ATC

interferon beta-1a; parenteral

18.5

13.4

H52.2

ICD-10 Finland

Astigmatism

26.1

13.4

CS494

NOMESCO Finland

Other visual field testing

4.9

13.3

H53.1

ICD-10 Finland

Subjective visual disturbances

2.9

13.2

293

T90

ICPC

Diabetes non-insulin dependent

1.8

13.1

263

1638

A10BB01

ATC

glibenclamide; oral

3.2

13.0

221

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

13.2

12.9

R42

ICD-10 Finland

Dizziness and giddiness

1.8

12.6

250

1545

CEC80

NOMESCO Finland

Partial transposition of extraocular muscle

+∞

12.5

3785A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Paralytic strabismus

+∞

12.5

9530/0-C70.0

ICD-O-3

Meningioma, NOS, of cerebral meninges

10.2

12.5

A10AB04

ATC

insulin lispro; parenteral (insulins and analog. for injection, fast-acting)

4.0

12.5

131

SPAT1262

SPAT

Handing over of treatment supplies

1.9

12.3

218

1299

A10BB12

ATC

glimepiride; oral

2.5

12.3

100

427

G70.0

ICD-10 Finland

Myasthenia gravis

38.0

12.2

C10AA01

ATC

simvastatin; oral

1.6

12.0

482

3635

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

5.1

11.8

L04AX07

ATC

dimethyl fumarate; oral

30.4

11.7

A28

ICPC

Limited function/disability NOS

1.9

11.4

177

1003

AA1BM

NOMESCO Finland

MRI examination of brain with 3 Tesla magnet

7.7

11.2

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

2.4

11.1

423

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

5.5

11.1

H3601, E103

ICD-10 Finland

9.3

11.0

H36.00

ICD-10 Finland

Diabetic background retinopathy

6.7

11.0

D32.06

ICD-10 Finland

Benign tumor of the meninges os petrosum or clivus area

43.8

10.9

H3603, E103

ICD-10 Finland

7.3

10.8

AA1AG

NOMESCO Finland

Short MRI examination of brain with median intensity magnet

5.9

10.8

A10AD05

ATC

insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)

4.3

10.7

L03AX13

ATC

glatiramer acetate; parenteral

21.7

10.7

D32.9

ICD-10 Finland

Benign neoplasm: Meninges, unspecified

13.1

10.7

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

3.2

10.6

178

H50.9

ICD-10 Finland

Strabismus, unspecified

60.6

10.6

H50.52

ICD-10 Finland

Exophoria

60.6

10.6

I60.9

ICD-10 Finland

Subarachnoid haemorrhage, unspecified

6.0

10.5

CEC90

NOMESCO Finland

Total transposition of extraocular muscle or muscles

+∞

10.4

XCD10

NOMESCO Finland

Electrophysiological examination of eye

3.9

10.4

107

PA6BG

NOMESCO Finland

MRI examination of neck vasculature with high intensity magnet

12.2

10.4

E10

ICD-10 Finland

Type 1 diabetes mellitus

5.2

10.4

H3600, E113

ICD-10 Finland

5.8

10.3

E11.3

ICD-10 Finland

Type 2 diabetes mellitus, with ophthalmic complications

3.6

10.3

128

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

2.3

10.3

454

CS5Z4

NOMESCO Finland

Specialised imaging for glaucoma

4.4

10.1

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

2.6

10.0

300

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

7.3

10.0

2500B

ICD-9 Finland

Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]

4.8

10.0

I10

ICD-10 Finland

Essential (primary) hypertension

1.5

9.9

619

5084

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

2.1

9.9

120

617

353

Kela drug reimbursment

Cladribine and fingolimod

26.3

9.8

R53

ICD-10 Finland

Malaise and fatigue

1.7

9.8

206

1288

Z3231

NOMESCO Finland

Registered nurse

1.6

9.6

292

2023

PA2CC

NOMESCO Finland

Cerebral very extensive angiography with X-ray

8.5

9.6

177

Kela drug reimbursment

Insulin glargine 300 U / ml

4.4

9.6

ZXD05

NOMESCO Finland

Urgent procedure

1.6

9.6

322

2287

CKC15

NOMESCO Finland

Panretinal photocoagulation

9.2

9.5

S06.2

ICD-10 Finland

Diffuse brain injury

7.2

9.5

N07AA02

ATC

pyridostigmine; systemic

15.2

9.5

A10AE06

ATC

insulin degludec; parenteral

4.0

9.5

I69.0

ICD-10 Finland

Sequelae of subarachnoid haemorrhage

6.7

9.5

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

1.8

9.4

173

1036

H50.8

ICD-10 Finland

Other specified strabismus

100.9

9.4

108

Kela drug reimbursment

Myasthenia gravis

30.3

9.4

XF400

NOMESCO Finland

ECG with 12 standard connections

1.8

9.4

182

1108

164

Kela drug reimbursment

Fingolimod

21.9

9.4

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.8

9.3

178

1077

A10AD01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)

4.1

9.3

H3603, E113

ICD-10 Finland

7.4

9.2

N03AX12

ATC

gabapentin; oral

1.8

9.2

161

948

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.6

8.8

287

2019

AAF00

NOMESCO Finland

Ventriculostomy

10.8

8.8

H52.3

ICD-10 Finland

Anisometropia and aniseikonia

50.4

8.7

H36.03

ICD-10 Finland

Proliferative diabetic retinopathy

7.0

8.6

CA1BG

NOMESCO Finland

Eye and orbita MRI examination with high intensity magnet

16.4

8.6

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

2.3

8.5

349

CS424

NOMESCO Finland

Visual field testing with Goldmann perimetry

7.4

8.5

E10.6

ICD-10 Finland

Type 1 diabetes mellitus, With other specified complications

12.9

8.4

E10.8

ICD-10 Finland

Type 1 diabetes mellitus, With unspecified complications

6.3

8.3

S18

ICPC

Laceration/cut

1.5

8.3

430

3346

H47.1

ICD-10 Finland

Papilloedema, unspecified

10.8

8.3

N86

ICPC

Multiple sclerosis

9.5

8.3

F05

ICPC

Visual disturbance other

3.5

8.1

105

H52.1

ICD-10 Finland

Myopia

7.3

8.0

ZXA10

NOMESCO Finland

Bilateral

1.6

7.9

198

1295

H16.0

ICD-10 Finland

Corneal ulcer

2.6

7.8

212

Z01.1

ICD-10 Finland

Examination of ears and hearing

1.8

7.8

141

839

H04AA01

ATC

glucagon; nasal, parenteral

3.8

7.8

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

1.7

7.7

178

1139

C09AA05

ATC

ramipril; oral

1.5

7.7

266

1885

CBH25

NOMESCO Finland

Tarsorrhaphy

45.3

7.7

N03AX16

ATC

pregabalin; oral

1.6

7.7

232

1592

E78.5

ICD-10 Finland

Hyperlipidaemia, unspecified

1.9

7.7

107

581

Z3229

NOMESCO Finland

Other healthcare associate professional

2.0

7.6

481

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

4.5

7.6

L04AA27

ATC

fingolimod; oral

25.2

7.6

A10BH01

ATC

sitagliptin; oral

1.9

7.6

107

586

H3600, E103

ICD-10 Finland

6.2

7.6

WX872

NOMESCO Finland

Intensive care

2.4

7.5

250

C09AA02

ATC

enalapril; systemic

1.6

7.5

212

1430

WX140

NOMESCO Finland

Parabulbar anesthesy

2.5

7.4

226

WX408

NOMESCO Finland

General anesthesy, balanced

1.5

7.4

261

1861

E78.01

ICD-10 Finland

Pure hypercholesterolaemia

1.6

7.4

208

1404

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

1.7

7.4

159

997

N01

ICPC

Headache

2.0

7.3

445

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

6.9

7.3

AAH50

NOMESCO Finland

Cranial nerve anastomosis

+∞

7.3

H50.4

ICD-10 Finland

Other and unspecified heterotropia

+∞

7.3

CS434

NOMESCO Finland

Visual field testing with Humphrey automated perimetry

3.4

7.3

E10.4

ICD-10 Finland

Type 1 diabetes mellitus, With neurological complications

7.4

7.2

CKC10

NOMESCO Finland

Local photocoagulation of retina

4.0

7.2

E11.4

ICD-10 Finland

Type 2 diabetes mellitus, with neurological complications

3.2

7.2

111

205

Kela drug reimbursment

Chronic hypertension

1.5

7.2

302

2235

CBK11

NOMESCO Finland

Operation for lagophtalmus with implant

30.2

7.2

SPAT1306

SPAT

Counselling and guidance related to nutrition and weight management

1.7

7.0

137

831

XCH00

NOMESCO Finland

Eye pressure measurement

2.6

7.0

194

AA1CD

NOMESCO Finland

Very extensive CT of head and brain

3.6

7.0

H36.09*E11.3

ICD-10 Finland

Non-insulin-dependent diabetes mellitus - Diabetic retinopathy

7.0

A10BD03

ATC

metformin and rosiglitazone; systemic

4.5

7.0

CKC12

NOMESCO Finland

Photocoagulation of retina

2.5

6.9

215

CA1CM

NOMESCO Finland

Eye and orbita extensive MRI examination with 3 Tesla magnet

13.9

6.9

ZXD10

NOMESCO Finland

Scheduled procedure

1.4

6.9

366

2836

TCW99

NOMESCO Finland

Other minor procedure in eye surgery

4.4

6.9

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.5

6.8

287

2118

L04AA31

ATC

teriflunomide; oral

40.3

6.8

N02BE01

ATC

paracetamol; systemic, rectal

1.5

6.7

866

7898

XA800

NOMESCO Finland

Neuropsychological investigation

2.6

6.6

171

G46.3*I67.9

ICD-10 Finland

Brain stem stroke syndrome (I60-I67+)

12.3

6.6

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

2.2

6.5

283

Z2446

NOMESCO Finland

Social worker

2.2

6.5

308

E11.5

ICD-10 Finland

Type 2 diabetes mellitus, with peripheral circulatory complications

3.2

6.5

L28

ICPC

Limited function/disability (L)

1.6

6.3

160

1047

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.4

6.3

313

2385

G91.1

ICD-10 Finland

Obstructive hydrocephalus

8.2

6.3

H47.2

ICD-10 Finland

Optic atrophy

11.1

6.3

H49.9

ICD-10 Finland

Paralytic strabismus, unspecified

+∞

6.3

D33.39

ICD-10 Finland

Benign tumor of the cranial nerves UNS

26.8

6.2

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

2.3

6.2

235

SPAT1148

SPAT

Treatment of chronic ulcer or burn

1.7

6.2

139

883

ZXA05

NOMESCO Finland

Left side

1.5

6.1

257

1891

TPH04

NOMESCO Finland

Cathetrisation of vein

1.5

6.1

203

1423

D43.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Brain, infratentorial

12.6

6.1

Mortality – FinRegistry

↥

Association

Association between endpoint H7_PARASTRA6 and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_PARASTRA6	1.239 [1.11, 1.39]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.18

During the follow-up period (1.1.1998 — 31.12.2019), 956 out of 3610 females with H7_PARASTRA6 died.

Males

Parameter	HR [95% CI]	p-value
H7_PARASTRA6	1.369 [1.21, 1.55]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 985 out of 3415 males with H7_PARASTRA6 died.

Mortality risk

Mortality risk for people of age

years, who have H7_PARASTRA6.

N-year risk	Females	Males
1	0.088%	0.26%
5	0.674%	1.56%
10	1.642%	4.144%
15	3.278%	7.631%
20	5.817%	12.723%

Relationships between endpoints

↥

Index endpoint: H7_PARASTRA6 – Sixth [abducent] nerve palsy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	H7_PARASTRA6
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H492
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H492
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Sixth [abducent] nerve palsy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints