No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
788 |
4. Check minimum number of eventsNone |
788 |
5. Include endpointsNone |
788 |
6. Filter based on genotype QC (FinnGen only) |
788 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H49
- Name in latin
- Paresis/paralysis nervi trochlearis
Similar endpoints
↥List of similar endpoints to
Fourth [trochlear] nerve palsy
based on the number of shared cases.
Similar with more cases:
- Paralytic strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4786 | 2139 | 2632 |
| Only index persons | 4492 | 2022 | 2470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.07 |
| Only index persons | 0.09 | 0.07 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 57.12 | 55.81 | 58.14 |
| Only index persons | 57.65 | 56.67 | 58.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 788 | 399 | 389 |
| Unadjusted period prevalence (%) | 0.15 | 0.14 | 0.17 |
| Median age at first event (years) | 59.43 | 55.47 | 63.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 722
- Matched controls
- 7218
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
323.0
722
*
H53.2
ICD-10 Finland
Diplopia
81.2
257.5
284
57
H50.2
ICD-10 Finland
Vertical strabismus
+∞
130.2
121
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
80.8
76
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.2
66.6
204
432
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.5
63.3
163
270
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
285.9
52.9
53
*
AA1AD
NOMESCO Finland
CT of head and brain
3.7
51.5
292
1112
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.3
37.3
124
274
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
36.8
35
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
35.7
34
*
H50.52
ICD-10 Finland
Exophoria
156.2
28.9
30
*
XCK00
NOMESCO Finland
Perimetry
4.8
27.3
97
227
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
27.3
171
651
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
23.0
22
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
22.0
21
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
205.3
19.6
20
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.6
19.6
51
82
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
8.2
18.0
40
51
CE2W4
NOMESCO Finland
Eye movement mapping
184.3
17.6
18
*
CEC20
NOMESCO Finland
Recession and advancement of extraocular muscle
+∞
16.7
16
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
16.0
342
2286
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
15.7
15
*
TAB00
NOMESCO Finland
Lumbar puncture
4.5
15.5
56
133
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.3
15.2
57
141
H50.31
ICD-10 Finland
Intermittent exotropia
+∞
14.6
14
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
10.0
14.3
28
29
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
14.8
14.1
23
16
T90.5
ICD-10 Finland
Sequelae of intracranial injury
11.2
14.1
26
24
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
13.6
13
*
H50.9
ICD-10 Finland
Strabismus, unspecified
+∞
13.6
13
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
13.2
301
2018
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
17.7
12.6
19
11
S06.2
ICD-10 Finland
Diffuse brain injury
9.2
11.8
24
27
SPAT1153
SPAT
Removal of sutures
1.8
11.8
251
1630
R51.80
ICD-10 Finland
Headache
2.3
11.7
115
549
H50.4
ICD-10 Finland
Other and unspecified heterotropia
+∞
11.5
11
*
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
35.6
11.3
14
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
10.9
223
1421
SPAT1301
SPAT
No procedures
1.8
10.6
240
1578
H50.8
ICD-10 Finland
Other specified strabismus
+∞
10.4
10
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.5
10.4
87
382
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.1
10.3
56
190
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
8.6
10.1
21
25
H53.1
ICD-10 Finland
Subjective visual disturbances
3.1
10.1
57
197
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
10.0
209
1334
UJF32
NOMESCO Finland
Coloscopy
1.8
9.9
191
1187
108
Kela drug reimbursment
Myasthenia gravis
30.4
9.4
12
*
H50.30
ICD-10 Finland
Intermittent esotropy
+∞
9.4
9
*
G70.0
ICD-10 Finland
Myasthenia gravis
22.0
9.4
13
6
S06.3
ICD-10 Finland
Focal brain injury
7.1
9.4
22
32
SPAT1263
SPAT
Sampling
1.6
9.0
301
2190
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.7
8.9
60
235
SPAT1310
SPAT
Counselling related to known health issue
1.7
8.5
226
1538
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
8.0
8.4
18
23
H52.0
ICD-10 Finland
Hypermetropia
12.9
8.4
14
11
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
+∞
8.3
8
*
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
8.3
8
*
PA7BD
NOMESCO Finland
CT angiography of neck and brain
5.6
8.3
23
42
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
8.2
154
942
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
8.2
122
689
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
11.9
8.1
14
12
WX110
NOMESCO Finland
Local anesthesy
1.6
8.0
469
3887
N07AA02
ATC
pyridostigmine; systemic
13.2
7.9
13
10
N06AX11
ATC
mirtazapine; oral
1.7
7.9
213
1452
CS494
NOMESCO Finland
Other visual field testing
4.8
7.9
25
54
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
7.8
295
2194
SPAT1312
SPAT
General health counselling
1.6
7.7
226
1572
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.8
7.7
24
51
WX140
NOMESCO Finland
Parabulbar anesthesy
3.0
7.6
41
140
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.2
7.5
72
340
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.5
605
5404
R42
ICD-10 Finland
Dizziness and giddiness
1.8
7.4
150
937
3503
FHL
Single muscle retroposition
+∞
7.3
7
*
CEC80
NOMESCO Finland
Partial transposition of extraocular muscle
+∞
7.3
7
*
ZXA10
NOMESCO Finland
Bilateral
1.8
7.3
135
819
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
7.2
277
2055
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.8
7.2
43
158
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
4.6
7.1
23
51
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
8.0
7.1
15
19
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
7.1
62
280
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
5.4
7.1
20
38
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.8
7.1
22
47
F05
ICPC
Visual disturbance other
4.0
7.0
26
66
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
7.0
118
692
N03AX14
ATC
levetiracetam; systemic
4.0
6.9
26
67
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.5
6.9
51
210
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
8.4
6.8
14
17
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.0
6.8
37
128
S06.0
ICD-10 Finland
Concussion
2.1
6.7
77
390
H52.1
ICD-10 Finland
Myopia
6.5
6.7
16
25
SPAT1260
SPAT
Consultation of another employee
1.7
6.6
131
812
H50.51
ICD-10 Finland
Esophoria
70.4
6.4
7
*
H52.2
ICD-10 Finland
Astigmatism
14.5
6.4
10
7
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
5.6
6.3
17
31
3785A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Paralytic strabismus
+∞
6.3
6
*
H50.59
ICD-10 Finland
Heterophor UNS
+∞
6.3
6
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
6.2
205
1458
G91.1
ICD-10 Finland
Obstructive hydrocephalus
26.9
6.2
8
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
26.9
6.2
8
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
39
12.75
47.44
1.1
1.1
1.7
2.9
nmol/l
—
6
7
355
2027
2.37
30.11
2.3
2.1
146.0
231.8
u/l
1.34
337
1909
389
2598
1.98
19.42
4.6
3.7
38.2
51.9
ng/l
0.37
282
1846
165
812
2.31
18.42
9.3
7.5
—
—
—
0
0
282
1779
1.91
15.84
4.6
4.0
0.0
0.0
estimate
0.69
84
608
25
43
5.97
14.06
1.2
1.1
117.5
41.7
mg/l
0.40
15
38
46
137
3.50
13.20
2.0
1.2
9.2
34.5
e6/l
0.54
37
107
46
137
3.50
13.20
1.9
1.3
162.0
917.9
e6/l
0.46
41
110
745
6690
3.08
12.66
20.8
17.2
139.7
139.6
mmol/l
0.48
732
6511
728
6475
2.63
12.37
17.2
14.8
21.7
24.8
mg/l
1.86
579
5164
745
6706
3.03
12.29
20.8
17.3
4.0
4.0
mmol/l
0.24
730
6521
22
40
5.63
11.70
1.2
1.0
—
—
—
0
0
489
3889
1.68
10.87
5.8
4.8
6.7
6.7
mmol/l
0.29
466
3646
399
3015
1.66
10.80
7.2
5.9
1.2
1.2
mmol/l
1.70
367
2746
675
5905
2.00
10.59
5.1
4.7
1.9
2.1
mu/l
0.50
610
5365
532
4358
1.68
10.25
5.5
4.4
180.4
2775.5
e6/l
—
5
76
419
3250
1.62
9.88
4.5
3.7
0.0
0.0
estimate
0.50
88
616
134
771
1.89
9.41
7.2
7.2
1.0
1.2
mmol/l
0.21
105
605
412
3208
1.60
9.37
5.4
5.0
0.0
0.0
estimate
0.50
90
633
411
3200
1.59
9.34
4.4
3.7
0.0
0.0
estimate
0.00
89
633
419
3284
1.59
9.20
7.7
6.7
1.2
1.2
mmol/l
1.21
350
2795
336
2507
1.59
9.06
4.6
3.9
—
—
—
0
0
242
1701
1.61
8.21
2.4
2.1
3.3
3.0
mg/l
0.76
221
1443
59
262
2.35
8.18
4.6
3.7
1.2
1.4
mmol/l
0.55
59
256
367
2841
1.55
8.16
4.8
4.7
35.7
35.3
g/l
0.59
343
2648
112
640
1.87
7.99
8.0
7.9
120.5
120.2
g/l
0.06
112
618
18
39
4.70
7.91
1.0
1.1
1.4
1.2
u/l
—
8
23
669
5985
1.78
7.73
6.2
5.9
40.3
40.0
mmol/mol
0.35
595
5531
161
1037
1.69
7.63
1.8
2.0
28.4
29.8
s
3.18
155
1003
564
4842
1.58
7.56
4.6
4.1
11.5
12.4
mm/h
0.79
511
4462
762
7167
2.92
7.28
27.2
22.0
134.5
135.1
g/l
0.48
752
7052
568
4904
1.57
7.24
4.3
3.9
15.3
14.8
pmol/l
4.03
503
4412
207
1442
1.59
7.14
4.8
4.0
1.0
1.0
kg/l
0.76
20
193
319
2450
1.51
7.06
3.7
3.3
—
—
—
0
0
103
598
1.83
6.97
2.8
2.4
10.4
7.2
ug/l
0.26
87
528
457
3785
1.49
6.93
8.8
9.1
4.1
4.2
e9/l
0.18
414
3340
23
67
3.51
6.88
1.1
1.1
—
—
—
0
0
674
6101
1.72
6.72
4.3
4.0
1.3
1.3
mmol/l
0.04
595
5561
20
54
3.77
6.67
1.2
1.1
—
—
—
0
0
386
3109
1.47
6.61
5.0
4.1
—
—
—
0
0
23
71
3.31
6.32
1.1
1.1
—
—
—
0
0
694
6362
1.76
6.24
4.8
4.5
4.5
4.6
mmol/l
3.07
620
5871
736
6876
2.07
6.17
12.4
10.6
24.9
26.0
u/l
1.26
704
6631
704
6485
1.80
6.16
5.3
5.0
2.6
2.7
mmol/l
3.31
632
5939
689
6313
1.73
6.08
4.8
4.5
1.4
1.5
mmol/l
0.16
608
5787
268
2035
1.48
6.06
3.3
3.0
1099.6
1397.0
ng/l
0.94
229
1764
575
5057
1.51
6.01
8.5
7.7
78.3
78.6
u/l
0.05
538
4738
686
6303
1.68
5.67
5.1
4.7
5.9
6.0
mmol/l
0.38
609
5716
415
3458
1.42
5.56
6.3
6.4
10.9
11.7
umol/l
1.06
387
3286
97
596
1.72
5.41
5.9
7.2
9.8
10.0
mmol/l
0.11
91
568
188
1358
1.50
5.34
1.2
1.2
0.7
1.8
u/ml
2.32
55
361
176
1274
1.49
4.91
1.9
1.7
1247.5
1183.8
nmol/l
0.41
138
958
127
858
1.57
4.87
4.7
4.5
33.1
31.6
%
0.73
92
582
128
868
1.57
4.83
5.9
5.6
1.1
1.0
mmol/l
0.51
118
805
23
87
2.69
4.52
3.0
2.9
27.4
24.2
mg/l
—
5
24
337
2779
1.37
4.47
3.1
2.8
149.4
137.5
ug/l
0.31
315
2554
155
1119
1.48
4.35
2.0
1.9
—
—
—
0
0
259
2063
1.38
4.20
3.1
2.5
52.8
57.0
u/l
1.63
236
1921
189
1426
1.43
4.20
1.6
1.7
66026083.3
12511071.7
pmol/l
0.38
156
1175
191
1450
1.42
4.09
1.8
1.7
1.2
1.2
mg/l
0.03
145
1113
189
1441
1.41
3.94
2.7
2.5
5.0
5.5
e6/l
0.21
170
1268
128
914
1.48
3.78
2.8
2.5
22.5
23.0
%
0.14
106
787
144
1062
1.44
3.59
2.7
2.5
13.6
12.9
umol/l
0.40
134
984
133
972
1.44
3.48
2.8
2.5
2.3
2.3
g/l
0.29
125
899
203
1600
1.36
3.42
2.8
2.4
—
—
—
0
0
10
27
3.74
3.36
2.0
1.2
—
—
—
0
0
231
1873
1.33
3.20
3.3
3.1
0.3
0.5
e6/l
1.59
189
1423
75
499
1.56
3.10
4.1
3.8
87.8
85.0
ng/l
0.09
64
445
13
46
2.86
2.93
2.1
1.7
—
—
—
0
0
77
527
1.51
2.81
2.1
2.8
61.0
66.8
ml/min/173m2
0.78
37
216
39
225
1.77
2.79
1.3
1.2
2.4
1.6
u/ml
—
6
18
140
1079
1.36
2.69
2.8
3.3
0.8
0.8
mmol/l
0.37
129
1010
12
43
2.82
2.65
1.1
1.2
—
—
—
0
0
33
186
1.81
2.57
1.9
1.9
—
—
—
0
0
12
44
2.75
2.55
1.8
2.1
435.0
770.5
e6/l
—
6
18
48
305
1.61
2.45
1.8
2.0
1.7
1.5
g/l
0.86
43
273
23
120
1.94
2.27
1.8
1.9
—
—
—
0
0
618
5821
1.29
2.22
16.1
15.7
38.6
39.7
%
1.25
357
4055
144
1151
1.31
2.16
3.0
2.8
1.2
1.1
e6/l
0.22
101
668
45
291
1.58
2.16
2.0
1.9
40.0
39.7
u/l
0.03
40
257
30
174
1.75
2.16
1.6
1.6
—
—
—
0
0
258
2216
1.24
2.15
2.9
3.5
2.3
2.3
mmol/l
0.20
218
1927
58
399
1.49
2.12
1.5
1.4
—
—
—
0
0
28
161
1.77
2.08
1.1
1.1
—
11.3
—
0
17
5
10
5.02
2.07
1.0
1.1
—
—
—
0
0
423
3838
1.22
2.06
3.0
2.9
—
—
—
0
0
28
162
1.76
2.04
1.6
1.8
—
—
—
0
0
113
880
1.33
2.04
28.2
24.9
1.6
1.3
inr
—
8
114
310
2731
1.22
2.01
2.2
2.0
94.4
94.4
pmol/l
0.00
166
1433
39
249
1.60
1.99
1.8
1.7
—
—
—
0
0
74
542
1.40
1.96
4.4
3.8
1.2
1.2
mmol/l
0.53
68
473
44
291
1.54
1.94
1.1
1.0
—
—
—
0
0
22
120
1.86
1.94
2.5
2.9
4.0
4.5
e9/l
0.61
22
120
48
324
1.51
1.93
3.7
2.5
0.7
0.7
%
0.32
48
313
458
4207
1.21
1.91
3.9
3.2
58.9
50.2
u/l
0.76
416
3923
12
52
2.33
1.88
1.0
1.0
—
—
—
0
0
8
28
2.88
1.86
1.4
2.1
—
—
—
0
0
8
28
2.88
1.86
1.4
2.1
—
—
—
0
0
286
2518
1.21
1.84
5.1
5.3
2.3
3.1
ug/l
1.01
256
2240
22
123
1.81
1.81
2.6
3.3
57.6
58.4
%
0.13
22
123
7
23
3.06
1.80
1.7
1.2
—
—
—
0
0
8
29
2.78
1.79
1.4
2.1
—
—
—
0
0
44
298
1.50
1.76
2.6
1.8
5.9
2.3
ug/l
0.31
37
267
18
95
1.92
1.76
1.4
1.6
—
—
—
0
0
108
855
1.30
1.75
1.4
1.4
—
—
—
0
0
6
18
3.35
1.75
2.5
1.8
—
—
—
0
0
32
202
1.61
1.74
1.2
1.2
—
—
—
0
0
74
556
1.37
1.71
1.7
3.2
67.4
66.7
g/l
0.41
64
508
128
1040
1.28
1.71
1.2
1.3
18.6
13.2
u/ml
0.19
48
385
150
1244
1.25
1.69
2.6
3.0
2.4
2.4
mmol/l
1.11
134
1090
133
1088
1.27
1.68
1.2
1.2
41.9
39.1
iu/ml
0.06
35
337
32
204
1.59
1.68
1.2
1.2
—
—
—
0
0
27
167
1.64
1.60
1.7
1.8
—
—
—
0
0
192
1648
1.22
1.57
1.7
1.5
23.0
20.4
nmol/l
0.45
167
1390
46
323
1.45
1.57
5.1
3.7
52.6
47.4
%
0.86
46
318
99
790
1.29
1.53
1.8
1.9
—
—
—
0
0
19
108
1.78
1.51
1.4
1.6
—
—
—
0
0
7
27
2.61
1.51
1.0
1.0
—
—
—
0
0
7
27
2.61
1.51
1.0
1.3
—
—
—
0
0
98
783
1.29
1.50
1.8
1.9
—
—
—
0
0
92
730
1.29
1.49
4.6
3.4
—
—
—
0
0
78
607
1.32
1.46
2.3
2.0
349.6
377.3
nmol/l
0.58
67
561
64
484
1.35
1.45
1.7
1.7
—
—
—
0
0
9
39
2.32
1.43
1.1
1.2
—
—
—
0
0
23
141
1.65
1.43
2.1
3.0
0.8
0.9
nmol/l
0.42
13
115
15
82
1.85
1.36
1.1
1.0
—
—
—
0
0
39
274
1.45
1.35
2.0
1.9
—
—
—
0
0
0
37
0.00
1.34
0.0
1.3
—
2.0
—
0
23
57
429
1.35
1.34
4.3
3.1
129.1
127.8
g/l
0.14
57
422
81
643
1.29
1.32
2.2
2.2
0.2
0.2
g/l
0.60
75
604
13
69
1.90
1.29
1.3
2.0
—
—
—
0
0
12
62
1.95
1.28
1.3
1.7
—
—
—
0
0
12
62
1.95
1.28
1.3
1.7
—
—
—
0
0
12
62
1.95
1.28
1.3
1.7
—
—
—
0
0
8
35
2.30
1.27
1.4
1.9
—
—
—
0
0
8
35
2.30
1.27
1.4
1.9
—
—
—
0
0
8
35
2.30
1.27
1.4
1.9
—
—
—
0
0
8
35
2.30
1.27
1.4
1.9
—
—
—
0
0
29
195
1.51
1.26
1.5
1.3
0.2
0.2
g/l
0.15
29
186
25
164
1.54
1.21
1.2
1.2
2.6
12.5
u/ml
—
8
25
30
205
1.48
1.21
1.5
1.3
1.2
1.2
g/l
0.02
30
196
288
2616
1.16
1.20
2.6
2.2
77.1
76.6
nmol/l
0.10
256
2311
26
173
1.52
1.19
1.4
1.4
—
—
—
0
0
6
26
2.32
1.19
3.2
3.2
25.2
34.0
umol/l
—
6
21
90
736
1.25
1.18
2.2
2.8
6.8
9.1
umol/l
1.08
70
655
24
158
1.54
1.16
1.1
1.1
—
—
—
0
0
5
21
2.39
1.09
1.0
1.2
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
5
21
2.39
1.09
1.0
1.1
—
—
—
0
0
77
627
1.25
1.06
4.7
3.5
1.9
2.0
mmol/l
0.09
68
498
634
6130
1.18
1.03
15.2
13.6
79.1
79.9
ml/min/173m2
0.41
557
5057
54
422
1.30
1.03
1.8
1.7
—
—
—
0
0
13
75
1.75
1.03
1.3
1.9
—
—
—
0
0
24
163
1.49
1.02
1.3
1.2
1.0
2.4
u/ml
—
5
16
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
222
1.41
1.02
1.9
2.4
0.4
0.3
u/ml
0.26
14
118
10
53
1.90
1.01
1.9
2.5
837.2
593.5
ml
—
5
32
19
124
1.55
0.97
1.4
1.6
—
—
—
0
0
12
69
1.75
0.97
1.1
1.1
—
—
—
0
0
47
366
1.30
0.93
1.5
1.3
201.8
233.3
u/ml
0.13
42
329
233
2121
1.14
0.92
3.3
3.1
7.7
7.7
mmol/l
0.02
189
1771
7
129
0.54
0.88
1.6
1.5
—
—
—
0
0
10
56
1.80
0.88
2.4
1.8
—
—
—
0
0
15
96
1.57
0.85
1.1
1.9
32.8
33.3
pg
0.13
15
96
8
45
1.79
0.84
1.0
1.2
—
—
—
0
0
231
2115
1.13
0.83
4.3
4.0
16.4
8.7
mg/mmol
0.76
150
1335
27
198
1.38
0.81
1.4
4.2
35.6
34.3
mg/l
0.08
20
159
16
235
0.67
0.80
1.4
1.7
2.9
3.1
mg/l
0.04
11
174
15
98
1.54
0.79
3.5
1.9
91.2
89.7
%
0.70
15
98
20
140
1.44
0.77
1.2
1.2
—
—
—
0
0
41
324
1.28
0.76
1.1
1.3
—
—
—
0
0
11
67
1.65
0.75
1.1
1.0
—
—
—
0
0
22
158
1.40
0.75
1.2
1.3
—
—
—
0
0
5
24
2.09
0.74
1.0
1.5
—
—
—
0
0
26
193
1.36
0.74
1.5
1.7
—
—
—
0
0
9
55
1.64
0.73
1.1
1.1
1.1
1.6
nmol/l
—
9
48
5
25
2.01
0.72
2.4
5.3
—
—
—
0
0
7
39
1.80
0.72
2.6
2.5
—
—
—
0
0
46
372
1.25
0.72
2.6
3.2
4.5
4.5
pmol/l
0.21
36
322
13
84
1.56
0.72
1.8
1.6
—
—
—
0
0
220
2028
1.12
0.71
4.9
4.5
23.4
21.0
%
1.59
122
1014
11
69
1.60
0.68
1.4
1.5
—
—
—
0
0
9
59
1.53
0.68
4.9
2.6
—
—
—
0
0
31
241
1.30
0.67
3.3
3.0
—
—
—
0
0
26
197
1.33
0.66
1.4
4.2
46.9
91.0
mg/l
0.72
20
157
13
86
1.52
0.66
1.7
1.5
52.3
63.1
%
—
6
64
27
206
1.32
0.66
1.3
1.3
—
—
—
0
0
14
96
1.47
0.61
3.1
2.7
105.5
105.4
mmol/l
0.03
14
96
14
96
1.47
0.61
3.1
2.7
4.1
4.0
mmol/l
0.45
14
96
8
51
1.57
0.60
1.0
1.2
—
—
—
0
0
8
52
1.54
0.59
1.0
1.2
—
—
—
0
0
14
97
1.45
0.59
1.5
1.6
—
—
—
0
0
10
64
1.57
0.58
1.0
1.1
—
—
—
0
0
16
115
1.40
0.57
1.3
1.3
—
—
—
0
0
13
90
1.45
0.55
1.6
1.6
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
37
1.63
0.55
1.0
1.2
—
—
—
0
0
22
171
1.29
0.50
2.4
2.5
125.3
90.3
ug/min
0.23
11
96
25
198
1.27
0.50
1.5
1.4
279.9
291.7
ug/g
0.11
15
119
26
207
1.26
0.50
2.0
1.6
—
—
—
0
0
51
437
1.18
0.49
3.7
3.8
1.5
1.8
mmol/l
0.25
40
338
42
496
0.84
0.49
1.6
1.8
—
—
—
0
0
186
1739
1.09
0.46
2.7
2.8
4791.1
6624.9
umol/l
0.23
164
1496
198
2103
0.92
0.44
2.8
3.3
35.3
33.2
u/l
0.26
186
2006
19
148
1.29
0.44
1.7
1.6
—
—
—
0
0
35
294
1.20
0.43
12.8
4.6
1.6
1.6
%
0.16
35
275
113
1035
1.11
0.43
1.4
1.5
—
—
—
0
0
11
78
1.42
0.43
1.4
1.2
59.4
54.5
u/l
—
5
55
19
149
1.28
0.42
4.0
2.5
18.1
15.7
%
—
6
76
0
15
0.00
0.41
0.0
1.1
—
1.1
—
0
6
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
14
106
1.33
0.39
1.2
1.1
—
—
—
0
0
11
80
1.38
0.38
1.0
1.1
125.6
116.4
%
0.46
11
74
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
5
37
1.35
0.37
2.2
1.8
—
—
—
0
0
13
99
1.32
0.35
1.2
1.1
—
—
—
0
0
20
164
1.23
0.33
1.4
1.4
—
—
—
0
0
62
560
1.12
0.32
1.9
1.9
—
—
—
0
0
28
239
1.18
0.31
2.0
1.7
—
—
—
0
0
77
708
1.10
0.30
3.7
4.4
7.0
29.2
ug/l
1.18
64
605
7
55
1.28
0.30
1.0
1.3
—
—
—
0
0
154
1459
1.07
0.29
2.9
3.2
0.7
0.8
ug/l
0.67
110
994
8
63
1.27
0.28
1.1
1.2
—
—
—
0
0
9
118
0.76
0.27
1.4
1.4
—
—
—
0
0
9
118
0.76
0.27
1.4
1.4
—
—
—
0
0
9
119
0.75
0.27
1.4
1.4
—
—
—
0
0
9
119
0.75
0.27
1.4
1.4
—
—
—
0
0
8
65
1.23
0.27
1.1
1.8
—
—
—
0
0
32
363
0.88
0.27
3.3
2.8
0.2
0.2
e6/l
0.09
32
352
9
74
1.22
0.25
2.1
2.9
—
—
—
0
0
16
133
1.21
0.24
1.6
1.5
—
—
—
0
0
10
78
1.29
0.24
2.4
1.8
—
—
—
0
0
102
1082
0.93
0.24
3.4
3.0
1.7
1.9
e6/l
0.22
60
602
5
38
1.32
0.23
2.2
1.7
—
—
—
0
0
5
38
1.32
0.23
1.0
1.4
—
62.0
—
0
5
22
190
1.16
0.23
1.5
1.4
—
—
—
0
0
5
40
1.25
0.22
1.4
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.6
—
1.3
—
0
11
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
12
98
1.23
0.21
1.2
1.5
—
—
—
0
0
527
5343
0.96
0.20
19.1
17.9
13.8
13.7
%
0.42
515
5240
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
12
99
1.22
0.19
2.3
1.7
—
—
—
0
0
20
228
0.87
0.19
1.5
2.7
3.0
3.2
g/l
0.26
13
179
19
216
0.88
0.18
1.4
2.9
0.5
1.3
g/l
0.81
13
188
14
163
0.86
0.17
1.4
1.5
—
—
—
0
0
17
149
1.14
0.15
2.2
2.3
131.8
130.1
g/l
—
8
109
22
244
0.90
0.15
1.5
2.6
7.6
7.4
g/l
0.13
13
186
22
244
0.90
0.15
1.5
2.6
3.7
3.8
g/l
0.06
13
176
22
244
0.90
0.15
1.5
2.6
—
—
—
0
0
11
129
0.85
0.15
1.5
1.3
—
—
—
0
0
11
129
0.85
0.15
1.5
1.3
—
—
—
0
0
19
169
1.13
0.14
2.4
2.1
4783.7
2744.7
u/l
—
7
61
10
84
1.19
0.14
1.0
1.1
—
—
—
0
0
19
170
1.12
0.13
1.2
1.3
—
—
—
0
0
65
620
1.05
0.12
1.9
2.0
—
—
—
0
0
11
96
1.15
0.10
1.3
1.5
—
—
—
0
0
23
212
1.09
0.10
1.5
1.5
—
—
—
0
0
5
46
1.09
0.09
2.2
1.7
—
—
—
0
0
10
87
1.15
0.09
1.0
1.1
1.5
1.5
g/l
—
10
78
57
593
0.96
0.09
2.0
2.3
50.3
34.4
u/l
0.46
48
501
21
226
0.93
0.08
1.5
2.7
9.1
10.5
g/l
1.08
15
193
11
98
1.12
0.07
1.3
1.5
—
—
—
0
0
12
132
0.91
0.06
1.9
1.6
—
—
—
0
0
19
177
1.08
0.06
1.5
1.3
—
—
—
0
0
177
1795
0.98
0.06
1.5
1.7
1.4
1.4
mmol/l
0.30
141
1487
52
504
1.03
0.05
2.1
2.2
11.9
12.4
nmol/l
0.14
42
448
15
161
0.93
0.05
1.3
1.5
—
—
—
0
0
29
302
0.96
0.04
2.3
1.8
—
—
—
0
0
75
737
1.02
0.03
1.6
1.8
1.4
1.5
%
1.47
63
635
18
173
1.04
0.01
1.2
1.3
76.6
232.0
miu/ml
—
5
78
19
197
0.96
0.01
1.3
2.8
36.5
37.5
g/l
0.27
14
169
42
413
1.02
0.01
1.1
1.3
115.4
154.6
iu/ml
0.26
19
176
10
97
1.03
0.00
1.3
1.5
—
—
—
0
0
10
97
1.03
0.00
1.3
1.5
—
—
—
0
0
10
98
1.02
0.00
1.3
1.5
—
—
—
0
0
12
122
0.98
0.00
1.0
1.1
—
—
—
0
0
21
209
1.00
0.00
1.4
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
9
93
0.97
0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
0.5
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
12.0
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
7.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
126
1260
1.00
0.00
3.5
3.9
72.1
387.1
ng/l
3.94
95
1002
6
60
1.00
0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
80.0
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRA4 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA4 | 1.027 [0.87, 1.22] | 0.763 |
| Birth year | 0.993 [0.98, 1.0] | 0.094 |
During the follow-up period (1.1.1998 — 31.12.2019), 244 out of 1915 females with H7_PARASTRA4 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA4 | 1.067 [0.92, 1.24] | 0.381 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 2325 males with H7_PARASTRA4 died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRA4.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.187% |
| 5 | 0.54% | 1.149% |
| 10 | 1.428% | 2.73% |
| 15 | 2.727% | 5.162% |
| 20 | 4.625% | 8.737% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRA4 – Fourth [trochlear] nerve palsy
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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