No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
826 |
4. Check minimum number of eventsNone |
826 |
5. Include endpointsNone |
826 |
6. Filter based on genotype QC (FinnGen only) |
802 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H49
- Name in latin
- Paresis/paralysis nervi trochlearis
Similar endpoints
↥List of similar endpoints to
Fourth [trochlear] nerve palsy
based on the number of shared cases.
Similar with more cases:
- Paralytic strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4786 | 2139 | 2632 |
| Only index persons | 4492 | 2022 | 2470 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.07 |
| Only index persons | 0.09 | 0.07 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 57.12 | 55.81 | 58.14 |
| Only index persons | 57.65 | 56.67 | 58.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 802 | 409 | 393 |
| Unadjusted period prevalence (%) | 0.16 | 0.15 | 0.18 |
| Median age at first event (years) | 60.21 | 56.59 | 63.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 826
- Matched controls
- 8260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H53.2
ICD-10 Finland
Diplopia
64.3
307.7
338
88
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
307.7
826
*
H50.2
ICD-10 Finland
Vertical strabismus
1682.6
148.6
140
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.2
107.7
224
467
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.6
100.5
188
352
CEC00
NOMESCO Finland
Recession of extraocular muscle
1006.9
93.8
90
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
65.5
62
*
AA1AD
NOMESCO Finland
CT of head and brain
3.2
57.2
360
1604
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
51.6
151
405
XCK00
NOMESCO Finland
Perimetry
4.8
42.6
103
236
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
38.9
37
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.8
37.6
61
96
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.9
37.0
218
902
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
372.9
36.3
36
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
8.1
30.9
42
54
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
29.3
28
*
H50.52
ICD-10 Finland
Exophoria
42.9
27.0
33
8
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
25.1
24
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
24.1
23
*
CE2W4
NOMESCO Finland
Eye movement mapping
89.4
23.8
26
*
T90.5
ICD-10 Finland
Sequelae of intracranial injury
8.8
22.9
29
34
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.3
22.5
61
152
CEC20
NOMESCO Finland
Recession and advancement of extraocular muscle
+∞
19.9
19
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
19.9
19
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
7.6
19.6
28
38
H50.9
ICD-10 Finland
Strabismus, unspecified
194.2
18.6
19
*
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
18.3
76
253
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
18.2
376
2509
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
17.8
17
*
TAB00
NOMESCO Finland
Lumbar puncture
3.6
17.6
61
181
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
17.2
423
2968
S06.3
ICD-10 Finland
Focal brain injury
6.8
15.8
25
38
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
7.1
15.3
23
33
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
14.9
67
233
H50.31
ICD-10 Finland
Intermittent exotropia
152.6
14.5
15
*
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
152.6
14.5
15
*
CS494
NOMESCO Finland
Other visual field testing
4.3
14.0
36
86
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
16.1
14.0
22
14
G51.0
ICD-10 Finland
Bell palsy
4.7
13.9
32
70
PA7BD
NOMESCO Finland
CT angiography of neck and brain
5.8
13.7
25
44
H50.8
ICD-10 Finland
Other specified strabismus
+∞
13.6
13
*
H50.4
ICD-10 Finland
Other and unspecified heterotropia
+∞
13.6
13
*
SPAT1312
SPAT
General health counselling
1.8
13.1
269
1750
SPAT1301
SPAT
No procedures
1.8
12.8
276
1818
R51.80
ICD-10 Finland
Headache
2.1
12.6
141
749
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
10.3
12.5
24
24
S06.2
ICD-10 Finland
Diffuse brain injury
9.5
12.5
25
27
SPAT1153
SPAT
Removal of sutures
1.7
12.4
287
1927
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
6.1
12.2
21
35
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.7
12.1
68
267
N03AX14
ATC
levetiracetam; systemic
4.1
12.0
33
83
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
11.6
253
1662
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
11.6
257
1696
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
11.5
11
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.2
10.9
103
512
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
4.4
10.8
27
63
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
10.5
325
2335
F95
ICPC
Strabismus
111.4
10.4
11
*
H50.30
ICD-10 Finland
Intermittent esotropy
+∞
10.4
10
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
10.4
191
1190
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
4.4
10.4
26
61
SPAT1310
SPAT
Counselling related to known health issue
1.7
10.4
266
1819
108
Kela drug reimbursment
Myasthenia gravis
23.7
10.3
14
6
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
9.3
10.1
20
22
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
10.0
150
878
G70.0
ICD-10 Finland
Myasthenia gravis
17.0
9.9
15
9
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.5
9.9
63
264
SPAT1263
SPAT
Sampling
1.6
9.8
343
2529
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.8
9.7
29
78
SPAT1260
SPAT
Consultation of another employee
1.8
9.5
152
907
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.8
9.4
49
185
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.1
9.2
90
452
L04AX01
ATC
azathioprine; systemic
3.1
9.2
39
132
UJF32
NOMESCO Finland
Coloscopy
1.7
9.0
221
1486
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
8.8
101
538
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
9.6
8.8
17
18
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
8.6
73
347
N07AA02
ATC
pyridostigmine; systemic
11.7
8.6
15
13
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
8.4
338
2548
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.0
8.4
37
128
3503
FHL
Single muscle retroposition
+∞
8.3
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
8.2
293
2148
N02BE01
ATC
paracetamol; systemic, rectal
1.9
8.1
724
6536
R42
ICD-10 Finland
Dizziness and giddiness
1.7
8.1
189
1250
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
10.2
8.0
15
15
H52.1
ICD-10 Finland
Myopia
6.4
8.0
20
32
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
8.0
116
670
ZXA10
NOMESCO Finland
Bilateral
1.7
7.9
158
1002
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.9
7.9
36
127
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
7.8
153
965
H25.0
ICD-10 Finland
Senile incipient cataract
2.3
7.8
59
268
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
7.8
72
355
A98
ICPC
Health maint/preventive medicine
2.6
7.6
791
7407
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
80.8
7.4
8
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.5
7.4
271
1991
AA1BD
NOMESCO Finland
Extensive CT of head and brain
3.3
7.3
27
84
CEC80
NOMESCO Finland
Partial transposition of extraocular muscle
+∞
7.3
7
*
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
5.9
7.2
19
33
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.9
7.2
34
122
H52.0
ICD-10 Finland
Hypermetropia
7.4
7.2
16
22
H02.4
ICD-10 Finland
Ptosis of eyelid
2.9
7.1
32
112
N29
ICPC
Neurological sympt/complt other
3.7
7.1
22
61
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.6
7.0
162
1065
UKC02
NOMESCO Finland
Cystoscopy
1.7
6.9
136
858
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.8
6.8
33
121
J01DB01
ATC
cefalexin; oral
1.6
6.8
655
5833
WX140
NOMESCO Finland
Parabulbar anesthesy
2.3
6.8
48
212
N28
ICPC
Limited function/disability (N)
3.8
6.7
20
54
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
7.9
6.6
14
18
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.6
545
4679
CA1AD
NOMESCO Finland
Orbita CT
70.4
6.4
7
*
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
14.4
6.4
10
7
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.3
6.3
45
199
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
5.6
6.3
17
31
B01AC04
ATC
clopidogrel; oral
1.6
6.3
144
943
SPAT1216
SPAT
Assessment of functional ability
1.7
6.3
133
854
H50
ICD-10 Finland
Other strabismus
+∞
6.3
6
*
H50.51
ICD-10 Finland
Esophoria
+∞
6.3
6
*
H50.59
ICD-10 Finland
Heterophor UNS
+∞
6.3
6
*
3785A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Paralytic strabismus
+∞
6.3
6
*
CEC85
NOMESCO Finland
Combined correction of cyclodeviation
+∞
6.3
6
*
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.9
6.2
75
407
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
4.0
6.2
17
43
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
6.2
96
565
XA800
NOMESCO Finland
Neuropsychological investigation
2.6
6.2
35
139
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
6.2
245
1818
F05
ICPC
Visual disturbance other
2.7
6.1
31
116
XX3DW
NOMESCO Finland
Time consuming IT work
1.8
6.1
97
574
A02BC02
ATC
pantoprazole; systemic
1.5
6.1
529
4545
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
3.2
6.1
23
73
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
41
12.92
50.85
1.1
1.1
1.68
5.32
nmol/l
—
6
9
372
2134
2.35
31.06
2.3
2.1
143.92
240.28
u/l
1.66
354
2014
407
2708
1.99
20.60
4.5
3.8
37.16
50.45
ng/l
0.38
297
1933
175
857
2.32
19.77
9.1
7.5
—
—
—
0
0
297
1852
1.94
17.42
4.6
4.0
0.00
0.01
estimate
0.69
88
627
454
3346
1.79
14.88
14.0
16.1
1.23
1.28
inr
0.55
122
995
49
148
3.46
13.75
1.9
1.3
150.98
881.69
e6/l
0.47
44
116
49
148
3.46
13.75
1.9
1.2
8.85
32.60
e6/l
0.54
39
113
25
46
5.57
13.13
1.2
1.1
117.47
42.22
mg/l
0.40
15
40
781
7028
3.04
12.91
20.6
17.3
139.74
139.65
mmol/l
0.52
768
6838
763
6802
2.60
12.57
16.9
14.8
21.58
24.91
mg/l
2.32
608
5426
781
7045
2.99
12.51
20.5
17.4
3.99
3.98
mmol/l
0.44
766
6851
420
3174
1.66
11.36
7.0
6.0
1.20
1.21
mmol/l
1.59
387
2905
710
6224
2.00
10.96
5.2
4.7
1.93
2.13
mu/l
0.49
641
5664
22
43
5.23
10.83
1.2
1.0
—
—
—
0
0
559
4577
1.68
10.81
5.5
4.4
176.33
2743.18
e6/l
—
6
79
441
3405
1.63
10.71
4.5
3.7
0.00
0.00
estimate
0.50
92
635
510
4086
1.65
10.66
5.8
4.9
6.66
6.71
mmol/l
0.26
486
3835
435
3358
1.62
10.49
5.4
4.9
0.00
0.00
estimate
0.50
94
653
435
3360
1.62
10.45
4.3
3.7
0.00
0.00
estimate
0.50
97
695
355
2624
1.62
10.11
4.6
3.8
—
—
—
0
0
16
12
13.57
9.69
1.1
1.1
—
—
—
0
0
141
817
1.88
9.66
7.1
7.6
0.92
1.31
mmol/l
0.50
112
651
20
41
4.97
9.35
1.0
1.0
1.32
1.13
u/l
—
9
26
438
3454
1.57
9.17
7.5
6.8
1.21
1.21
mmol/l
1.08
369
2958
26
70
3.80
8.67
1.1
1.1
—
—
—
0
0
119
676
1.89
8.63
7.8
8.4
120.71
120.20
g/l
0.10
119
659
62
277
2.34
8.46
4.5
4.0
1.21
1.35
mmol/l
0.65
62
270
221
1508
1.64
8.40
4.8
4.0
1.01
1.02
kg/l
0.71
21
203
23
58
4.05
8.38
1.1
1.1
—
—
—
0
0
598
5133
1.60
8.14
4.4
3.9
15.27
14.83
pmol/l
4.15
527
4624
594
5096
1.59
8.05
4.6
4.1
11.52
12.50
mm/h
0.92
538
4695
703
6302
1.78
7.93
6.2
5.9
40.34
39.94
mmol/mol
0.48
626
5827
251
1788
1.58
7.92
2.4
2.1
3.28
3.06
mg/l
0.65
228
1516
800
7518
3.04
7.88
26.6
21.9
245.46
246.35
e9/l
0.15
785
7333
26
75
3.55
7.87
1.1
1.1
—
—
—
0
0
800
7519
3.03
7.86
26.6
22.0
40.18
40.06
%
0.20
749
7011
800
7521
3.02
7.81
26.7
21.9
4.48
4.47
e12/l
0.12
785
7318
800
7524
3.01
7.75
26.9
22.0
134.73
135.13
g/l
0.32
790
7405
169
1099
1.68
7.68
1.7
1.9
28.44
29.75
s
3.05
163
1064
381
2990
1.51
7.65
4.7
4.7
35.71
35.36
g/l
0.62
357
2790
335
2568
1.51
7.48
3.7
3.2
—
—
—
0
0
478
3977
1.48
6.92
8.8
9.1
4.11
4.15
e9/l
0.13
432
3511
708
6421
1.72
6.87
4.3
4.0
1.29
1.29
mmol/l
0.11
627
5858
774
7220
2.14
6.82
12.3
10.6
24.92
26.05
u/l
1.36
741
6966
282
2120
1.50
6.76
3.3
3.1
1057.13
1389.69
ng/l
1.18
240
1841
404
3265
1.46
6.71
3.1
2.6
—
—
—
0
0
106
635
1.77
6.43
2.7
2.4
10.18
6.94
ug/l
0.27
89
562
740
6822
1.81
6.43
5.3
5.0
2.57
2.71
mmol/l
3.64
667
6258
729
6692
1.76
6.43
4.8
4.5
4.45
4.60
mmol/l
3.09
654
6183
723
6624
1.73
6.39
5.0
4.7
5.94
5.98
mmol/l
0.28
643
6012
724
6642
1.73
6.28
4.8
4.5
1.45
1.45
mmol/l
0.00
642
6095
439
3641
1.44
6.15
6.2
6.4
10.78
11.61
umol/l
1.17
411
3461
602
5316
1.49
5.94
8.5
7.7
77.84
78.50
u/l
0.13
564
4988
82
468
1.84
5.84
11.0
6.9
24.40
24.70
mmol/l
0.33
82
444
198
1429
1.51
5.63
1.2
1.2
0.70
1.78
u/ml
2.41
58
384
185
1338
1.49
5.16
1.9
1.7
1257.97
1180.64
nmol/l
0.53
144
1006
99
624
1.67
5.00
5.8
7.1
9.69
9.92
mmol/l
0.12
93
596
273
2160
1.39
4.63
3.1
2.5
52.78
95.73
u/l
0.61
250
2013
132
914
1.53
4.50
5.8
5.5
1.06
1.03
mmol/l
0.47
122
841
130
899
1.53
4.46
4.7
4.5
33.10
31.70
%
0.70
92
614
200
1513
1.42
4.35
2.6
2.5
4.99
5.34
e6/l
0.14
179
1360
200
1519
1.42
4.25
1.8
1.6
1.17
1.18
mg/l
0.02
151
1167
23
90
2.60
4.25
3.0
2.8
27.40
24.22
mg/l
—
5
24
350
2917
1.35
4.18
3.1
2.8
146.46
136.44
ug/l
0.26
327
2680
159
1167
1.45
4.06
2.0
1.9
—
—
—
0
0
196
1497
1.41
4.01
1.7
1.7
63975597.63
8692557.59
pmol/l
0.41
161
1231
246
1960
1.36
3.89
3.3
3.1
0.36
0.49
e6/l
0.49
202
1495
133
962
1.46
3.66
2.7
2.5
22.48
23.03
%
0.15
111
829
6
6
10.06
3.50
1.3
1.0
—
—
—
0
0
83
552
1.56
3.41
2.1
2.9
61.88
66.36
ml/min/173m2
0.62
42
231
149
1117
1.41
3.37
2.7
2.4
13.50
12.95
umol/l
0.34
139
1040
212
1688
1.34
3.30
2.8
2.4
—
—
—
0
0
137
1023
1.41
3.16
2.7
2.4
2.34
2.29
g/l
0.44
129
946
77
522
1.52
2.93
4.0
3.7
87.29
84.87
ng/l
0.08
66
465
41
238
1.76
2.86
1.3
1.2
2.43
1.58
u/ml
—
6
19
213
1733
1.31
2.81
3.4
3.9
90.22
88.81
%
0.34
202
1695
13
48
2.74
2.72
2.1
1.6
—
—
—
0
0
154
1207
1.34
2.63
2.9
2.8
1.23
1.07
e6/l
0.21
109
703
10
30
3.36
2.61
2.0
1.2
—
—
—
0
0
371
3259
1.25
2.59
6.6
5.8
56.51
57.40
%
0.71
339
3078
376
3308
1.25
2.59
7.0
6.0
28.33
27.47
%
0.77
345
3119
62
415
1.53
2.52
1.5
1.4
—
—
—
0
0
48
304
1.61
2.47
1.9
1.9
39.79
39.80
u/l
0.00
43
268
50
322
1.59
2.41
1.7
2.0
1.66
1.47
g/l
0.84
45
285
34
199
1.74
2.35
1.9
1.8
—
—
—
0
0
144
1139
1.32
2.31
2.9
3.3
0.83
0.81
mmol/l
0.85
135
1067
116
890
1.35
2.29
1.4
1.4
—
—
—
0
0
483
4411
1.23
2.23
3.8
3.1
58.39
50.16
u/l
0.75
439
4119
11
41
2.71
2.21
1.3
1.2
—
—
—
0
0
8
24
3.36
2.18
1.6
1.2
—
—
—
0
0
29
166
1.77
2.18
1.8
1.9
4.95
5.65
iu/l
—
6
50
78
566
1.42
2.15
4.3
3.8
1.23
1.22
mmol/l
0.38
71
493
46
300
1.56
2.13
1.1
1.0
—
—
—
0
0
31
183
1.72
2.10
1.6
1.6
—
—
—
0
0
442
4014
1.22
2.10
3.0
2.9
—
—
—
0
0
326
2873
1.22
2.09
2.2
2.0
94.10
94.75
pmol/l
0.09
173
1505
100
763
1.35
2.06
2.7
2.1
132.69
144.85
ug/g
0.21
75
599
302
2650
1.22
2.01
5.2
5.3
2.32
3.03
ug/l
0.90
271
2360
23
126
1.85
2.00
1.8
1.8
—
—
—
0
0
269
2334
1.23
2.00
2.8
3.5
2.34
2.35
mmol/l
0.25
230
2048
8
27
2.98
1.94
1.0
1.3
—
—
—
0
0
23
128
1.82
1.91
2.6
2.8
3.95
4.39
e9/l
0.56
23
128
136
1099
1.28
1.87
1.2
1.3
17.90
12.67
u/ml
0.19
50
411
30
182
1.67
1.87
1.4
1.4
—
—
—
0
0
5
12
4.19
1.82
1.0
1.1
—
—
—
0
0
8
29
2.78
1.79
1.4
2.1
—
—
—
0
0
8
29
2.78
1.79
1.4
2.1
—
—
—
0
0
23
131
1.78
1.79
2.7
3.2
57.70
58.23
%
0.09
23
131
83
630
1.35
1.78
2.2
2.1
363.61
375.39
nmol/l
0.20
71
582
141
1152
1.27
1.78
1.2
1.3
40.60
38.98
iu/ml
0.04
40
369
28
170
1.67
1.76
1.6
1.8
—
—
—
0
0
12
54
2.24
1.74
1.0
1.0
—
—
—
0
0
8
30
2.68
1.72
1.4
2.0
—
—
—
0
0
45
309
1.48
1.70
2.6
1.8
5.76
2.26
ug/l
0.31
38
276
39
261
1.52
1.66
1.8
1.7
—
—
—
0
0
6
20
3.01
1.58
2.5
1.7
—
—
—
0
0
7
26
2.71
1.58
2.9
3.3
26.00
34.10
umol/l
—
7
21
18
99
1.84
1.58
1.4
1.6
—
—
—
0
0
32
209
1.55
1.53
1.2
1.2
—
—
—
0
0
103
826
1.28
1.53
1.8
1.9
—
—
—
0
0
24
146
1.66
1.52
2.1
3.0
0.76
0.87
nmol/l
0.57
14
115
102
819
1.28
1.50
1.8
1.9
—
—
—
0
0
14
72
1.96
1.49
1.1
1.1
—
—
—
0
0
200
1732
1.20
1.48
1.6
1.5
22.56
20.27
nmol/l
0.41
173
1462
32
211
1.54
1.48
1.2
1.2
—
—
—
0
0
31
203
1.55
1.47
1.5
1.3
0.23
0.24
g/l
0.26
31
194
6
22
2.74
1.43
1.0
1.1
—
—
—
0
0
6
22
2.74
1.43
1.0
1.1
—
—
—
0
0
6
22
2.74
1.43
1.0
1.2
—
—
—
0
0
6
22
2.74
1.43
1.0
1.1
—
—
—
0
0
95
761
1.28
1.43
4.6
3.4
—
—
—
0
0
47
338
1.41
1.43
5.0
3.6
52.43
47.62
%
0.78
47
333
32
213
1.52
1.42
1.5
1.3
1.17
1.18
g/l
0.06
32
204
27
173
1.58
1.41
1.3
1.2
2.61
11.90
u/ml
—
8
28
76
593
1.31
1.40
1.7
3.2
67.26
66.62
g/l
0.37
66
543
19
112
1.71
1.36
1.4
1.6
—
—
—
0
0
671
6456
1.21
1.35
15.2
13.7
78.77
79.92
ml/min/173m2
0.68
587
5336
237
2102
1.18
1.33
3.4
3.2
634.76
250.02
mg/l
0.47
149
1359
96
778
1.26
1.33
2.2
2.8
6.89
9.04
umol/l
1.06
75
685
66
510
1.32
1.31
1.7
1.7
—
—
—
0
0
84
671
1.28
1.31
2.2
2.3
0.20
0.21
g/l
0.61
77
632
6
24
2.51
1.30
1.2
1.0
1739.00
1676.96
miu/ml
—
6
24
27
177
1.54
1.30
1.7
1.7
—
—
—
0
0
25
161
1.57
1.30
1.1
1.1
—
—
—
0
0
15
84
1.80
1.27
1.1
1.0
—
—
—
0
0
9
44
2.06
1.27
1.1
1.1
40.44
27.38
u/l
—
9
44
9
44
2.06
1.27
1.1
1.1
106.67
92.30
u/l
—
9
44
52
392
1.35
1.23
1.5
1.3
188.74
226.16
u/ml
0.18
47
354
26
172
1.53
1.22
1.3
1.2
0.98
2.33
u/ml
—
5
17
8
37
2.17
1.21
1.4
1.9
—
—
—
0
0
8
37
2.17
1.21
1.4
1.9
—
—
—
0
0
14
78
1.81
1.21
1.3
1.9
—
—
—
0
0
12
64
1.89
1.18
1.3
1.7
—
—
—
0
0
12
64
1.89
1.18
1.3
1.7
—
—
—
0
0
12
64
1.89
1.18
1.3
1.7
—
—
—
0
0
13
72
1.82
1.15
1.3
1.9
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.1
—
—
—
0
0
153
1324
1.19
1.15
2.6
3.0
2.43
2.45
mmol/l
1.38
136
1163
39
286
1.38
1.11
2.0
1.9
—
—
—
0
0
7
31
2.27
1.10
1.0
1.0
—
—
—
0
0
58
454
1.30
1.08
4.3
3.2
129.40
127.17
g/l
0.27
58
446
238
2147
1.15
1.06
3.4
3.2
75.24
108.26
e6/l
0.36
192
1666
10
52
1.93
1.06
1.0
1.2
—
—
—
0
0
236
2130
1.15
1.05
4.8
4.5
23.04
20.96
%
1.35
127
1073
29
204
1.44
1.04
1.5
1.7
—
—
—
0
0
10
53
1.90
1.01
1.0
1.2
—
—
—
0
0
7
132
0.53
0.99
1.6
1.5
—
—
—
0
0
16
100
1.61
0.97
3.4
1.9
90.46
89.67
%
0.26
16
100
299
2760
1.13
0.94
2.6
2.2
77.44
76.90
nmol/l
0.12
266
2437
6
27
2.23
0.93
2.5
5.0
—
—
—
0
0
55
440
1.27
0.90
1.8
1.7
—
—
—
0
0
10
56
1.80
0.88
1.9
2.4
837.20
597.82
ml
—
5
34
11
64
1.73
0.86
1.0
1.1
—
—
—
0
0
17
251
0.67
0.86
1.4
1.8
2.94
3.06
mg/l
0.03
11
193
49
389
1.28
0.86
3.3
3.2
4.47
4.58
pmol/l
0.37
39
339
243
2228
1.13
0.84
3.4
3.1
7.72
7.68
mmol/l
0.05
196
1867
15
97
1.56
0.81
3.1
2.8
105.53
105.38
mmol/l
0.06
15
97
15
97
1.56
0.81
3.1
2.8
4.14
4.02
mmol/l
0.69
15
97
14
89
1.58
0.81
1.6
1.7
52.33
63.80
%
—
6
66
19
130
1.47
0.81
1.4
1.6
—
—
—
0
0
242
2224
1.12
0.81
4.1
3.8
15.84
8.38
mg/mmol
0.76
156
1404
21
148
1.43
0.78
1.2
1.2
—
—
—
0
0
10
59
1.70
0.76
2.4
1.7
—
—
—
0
0
5
24
2.09
0.74
1.0
1.5
—
—
—
0
0
78
664
1.19
0.74
4.6
3.5
1.80
2.05
mmol/l
0.27
69
539
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
237
1.32
0.73
1.9
2.5
0.38
0.35
u/ml
0.16
14
130
7
39
1.80
0.72
1.0
1.1
—
—
—
0
0
9
57
1.59
0.71
1.1
1.1
1.14
1.54
nmol/l
—
9
49
5
26
1.93
0.70
1.0
1.0
—
—
—
0
0
15
101
1.49
0.70
1.1
1.8
32.80
33.06
pg
0.07
15
101
28
213
1.33
0.69
1.4
4.3
35.61
35.14
mg/l
0.03
20
171
28
213
1.33
0.69
1.3
1.3
—
—
—
0
0
13
85
1.54
0.69
1.8
1.6
—
—
—
0
0
7
42
1.67
0.68
2.6
2.5
—
—
—
0
0
55
457
1.22
0.68
3.5
3.7
1.43
1.80
mmol/l
0.43
42
350
22
162
1.37
0.66
1.2
1.3
—
—
—
0
0
11
70
1.58
0.65
1.4
1.5
—
—
—
0
0
17
120
1.43
0.65
1.2
1.7
—
—
—
0
0
17
120
1.43
0.65
1.2
1.7
—
—
—
0
0
27
207
1.31
0.64
1.5
1.4
291.67
287.06
ug/g
0.04
18
125
5
30
1.67
0.61
4.0
2.0
30.58
293.75
ug/l
—
5
25
17
122
1.40
0.60
1.2
1.3
—
—
—
0
0
8
52
1.54
0.59
1.0
1.2
—
—
—
0
0
17
123
1.39
0.58
2.4
1.8
5.28
4.82
mmol/24h
0.18
12
106
32
256
1.26
0.57
3.2
2.9
—
—
—
0
0
41
338
1.22
0.57
1.1
1.3
—
—
—
0
0
27
212
1.28
0.56
1.4
4.3
46.93
86.68
mg/l
0.68
20
169
12
82
1.47
0.54
1.3
1.2
48.42
52.70
u/l
0.18
12
77
13
91
1.44
0.53
1.6
1.6
—
—
—
0
0
27
214
1.27
0.53
2.0
1.6
—
—
—
0
0
9
63
1.43
0.52
4.6
2.4
—
—
—
0
0
23
179
1.29
0.51
2.0
2.4
115.08
88.06
ug/min
0.19
12
101
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
40
1.50
0.51
1.0
1.1
—
—
—
0
0
37
306
1.22
0.51
12.2
5.0
1.61
1.60
%
0.03
37
286
15
109
1.38
0.51
1.2
1.1
—
—
—
0
0
20
153
1.31
0.50
3.9
2.5
18.27
15.80
%
—
7
79
22
171
1.29
0.50
1.4
1.4
—
—
—
0
0
14
102
1.38
0.47
1.5
1.6
—
—
—
0
0
165
1534
1.09
0.46
2.9
3.2
0.72
0.77
ug/l
0.48
117
1046
5
84
0.59
0.45
1.4
1.3
—
—
—
0
0
117
1074
1.10
0.43
1.5
1.4
—
—
—
0
0
194
1825
1.08
0.42
2.7
2.8
4559.05
6531.71
umol/l
0.27
173
1585
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
1.08
—
0
6
7
105
0.66
0.39
1.1
1.6
—
—
—
0
0
33
387
0.85
0.38
3.3
2.8
0.18
0.23
e6/l
0.26
33
376
24
197
1.22
0.38
1.6
1.5
0.00
0.11
iu/ml
—
5
35
20
162
1.24
0.36
19.8
6.7
107.90
105.21
mmol/l
1.51
20
146
6
42
1.43
0.35
1.3
1.6
—
—
—
0
0
9
122
0.73
0.35
1.4
1.4
—
—
—
0
0
9
122
0.73
0.35
1.4
1.4
—
—
—
0
0
210
2206
0.94
0.35
2.8
3.3
35.22
33.32
u/l
0.26
197
2097
6
86
0.70
0.33
1.0
1.3
6.17
7.10
mmol/l
—
6
72
46
517
0.88
0.32
1.6
1.8
—
—
—
0
0
82
753
1.10
0.32
3.6
4.3
6.68
28.09
ug/l
1.22
69
641
19
230
0.82
0.32
1.4
2.9
0.47
1.31
g/l
0.81
13
201
19
156
1.22
0.31
2.1
2.3
137.20
130.18
g/l
—
10
116
10
75
1.34
0.30
1.4
1.3
252.20
317.06
pmol/l
—
10
64
13
102
1.28
0.30
1.2
1.1
—
—
—
0
0
19
157
1.22
0.29
1.7
1.6
—
—
—
0
0
7
57
1.23
0.29
1.0
1.3
—
—
—
0
0
9
121
0.74
0.27
1.4
1.4
—
—
—
0
0
9
121
0.74
0.27
1.4
1.4
—
—
—
0
0
8
66
1.21
0.26
1.1
1.2
—
—
—
0
0
8
67
1.20
0.26
1.1
1.9
—
—
—
0
0
11
86
1.28
0.26
1.0
1.1
125.64
115.96
%
0.49
11
77
23
198
1.17
0.25
1.5
1.4
—
—
—
0
0
11
137
0.80
0.24
1.5
1.3
—
—
—
0
0
11
137
0.80
0.24
1.5
1.3
—
—
—
0
0
30
339
0.88
0.24
5.2
3.6
22.61
24.15
mmol/l
1.78
30
333
21
244
0.86
0.24
1.5
2.7
2.78
3.01
g/l
0.42
16
219
5
39
1.28
0.23
1.0
1.4
—
62.00
—
0
5
5
40
1.25
0.22
2.2
1.7
—
—
—
0
0
5
41
1.22
0.22
1.2
1.3
209.00
156.47
pmol/l
—
5
41
5
41
1.22
0.22
2.2
1.7
—
—
—
0
0
57
527
1.09
0.21
2.0
2.2
12.26
12.35
nmol/l
0.02
46
472
0
10
0.00
0.21
0.0
1.7
—
1.26
—
0
10
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
23
260
0.88
0.19
1.5
2.6
3.49
3.63
g/l
0.21
18
235
23
260
0.88
0.19
1.5
2.6
—
—
—
0
0
23
260
0.88
0.19
1.5
2.6
7.54
7.33
g/l
0.18
18
235
16
137
1.17
0.19
1.6
1.5
—
—
—
0
0
81
765
1.07
0.19
1.6
1.8
1.36
1.51
%
1.65
66
657
28
252
1.12
0.18
2.0
1.8
—
—
—
0
0
5
66
0.76
0.17
1.0
1.1
105.00
97.85
%
—
5
60
29
318
0.91
0.16
2.2
1.9
—
—
—
0
0
24
216
1.11
0.15
1.6
1.7
—
—
—
0
0
109
1135
0.95
0.15
3.3
3.0
1.77
2.04
e6/l
0.23
65
633
16
140
1.15
0.15
1.4
1.2
25.68
31.04
u/ml
—
5
12
9
83
1.09
0.14
2.1
2.8
—
—
—
0
0
10
84
1.19
0.14
2.4
1.8
—
—
—
0
0
12
103
1.17
0.13
1.3
1.5
—
—
—
0
0
15
170
0.88
0.13
1.5
1.5
—
—
—
0
0
19
211
0.90
0.13
1.3
2.8
36.53
37.58
g/l
0.30
14
186
22
242
0.91
0.13
1.5
2.7
9.06
10.58
g/l
1.42
17
216
19
171
1.11
0.12
2.4
2.1
4783.71
2701.35
u/l
—
7
62
20
181
1.11
0.12
1.2
1.3
—
—
—
0
0
61
581
1.05
0.12
1.9
1.9
—
—
—
0
0
24
220
1.09
0.12
1.7
1.3
31.02
27.96
iu/l
0.12
19
189
23
211
1.09
0.11
1.5
1.5
—
—
—
0
0
12
105
1.14
0.11
2.3
1.7
—
—
—
0
0
46
437
1.06
0.10
1.2
1.2
109.66
149.02
iu/ml
0.27
20
185
5
64
0.78
0.08
1.8
2.3
—
—
—
0
0
12
133
0.90
0.07
1.9
1.6
—
—
—
0
0
9
84
1.07
0.07
1.1
1.6
—
—
—
0
0
9
84
1.07
0.07
1.1
1.6
—
—
—
0
0
11
122
0.90
0.07
1.0
1.1
259.60
283.67
u/ml
—
5
70
10
90
1.11
0.05
1.0
1.1
—
—
—
0
0
11
101
1.09
0.04
1.3
1.5
—
—
—
0
0
16
169
0.95
0.03
1.3
1.5
—
—
—
0
0
19
181
1.05
0.03
1.2
1.3
76.60
230.73
miu/ml
—
5
84
11
103
1.07
0.02
1.3
1.5
—
—
—
0
0
188
1890
0.99
0.01
1.5
1.7
1.42
1.37
mmol/l
0.24
151
1562
62
627
0.99
0.01
2.0
2.3
49.25
35.91
u/l
0.39
51
531
10
94
1.06
0.01
1.0
1.1
1.50
1.53
g/l
—
10
83
586
5854
1.00
0.00
18.4
17.5
15.40
15.11
%
0.50
576
5762
13
126
1.03
0.00
1.0
1.1
—
—
—
0
0
10
103
0.97
0.00
1.3
1.5
—
—
—
0
0
19
187
1.02
0.00
1.5
1.4
—
—
—
0
0
10
102
0.98
0.00
1.3
1.5
—
—
—
0
0
10
102
0.98
0.00
1.3
1.5
—
—
—
0
0
131
1315
1.00
0.00
3.4
3.9
69.62
377.68
ng/l
4.08
100
1046
64
641
1.00
0.00
1.9
2.0
—
—
—
0
0
6
62
0.97
0.00
1.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
95
0.95
-0.00
1.2
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
12.03
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
80.00
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
0.50
—
0
8
0
8
0.00
-0.00
0.0
7.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
49
1.02
-0.00
2.2
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRA4 and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA4 | 1.027 [0.87, 1.22] | 0.763 |
| Birth year | 0.993 [0.98, 1.0] | 0.094 |
During the follow-up period (1.1.1998 — 31.12.2019), 244 out of 1915 females with H7_PARASTRA4 died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRA4 | 1.067 [0.92, 1.24] | 0.381 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 2325 males with H7_PARASTRA4 died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRA4.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.187% |
| 5 | 0.54% | 1.149% |
| 10 | 1.428% | 2.73% |
| 15 | 2.727% | 5.162% |
| 20 | 4.625% | 8.737% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRA4 – Fourth [trochlear] nerve palsy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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