Risteys · H7_PARASTRA3

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H49.0 Cause of death: ICD-10 — H49.0 2 out of 7 registries used, show all original rules.	624
4. Check minimum number of events None	624
5. Include endpoints None	624
6. Filter based on genotype QC (FinnGen only)	624

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	4483	2283	2171
Only index persons	3953	2021	1932
Unadjusted period prevalence (%)
Whole population	0.06	0.07	0.06
Only index persons	0.07	0.07	0.07
Median age at first event (years)
Whole population	65.73	66.58	64.73
Only index persons	64.72	65.45	63.95

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	624	326	298
Unadjusted period prevalence (%)	0.12	0.11	0.13
Median age at first event (years)	62.15	58.96	65.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
571: Matched controls
5708

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H49.0

ICD-10 Finland

Third [oculomotor] nerve palsy

+∞

323.0

571

H53.2

ICD-10 Finland

Diplopia

50.1

159.1

192

H49.2

ICD-10 Finland

Sixth [abducent] nerve palsy

754.6

69.6

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

8.2

56.4

137

212

AA1AD

NOMESCO Finland

CT of head and brain

4.4

54.1

262

922

XCW99

NOMESCO Finland

Other investigative procedure of eye

5.8

46.6

149

329

D32.02

ICD-10 Finland

Benign tumor of the meninges at the base of the brain

54.0

45.7

XCK00

NOMESCO Finland

Perimetry

7.2

45.1

118

199

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.3

38.9

170

513

H49.1

ICD-10 Finland

Fourth [trochlear] nerve palsy

357.2

34.3

H02.4

ICD-10 Finland

Ptosis of eyelid

9.5

33.5

I67.1

ICD-10 Finland

Cerebral aneurysm, nonruptured

15.9

33.5

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

10.4

28.1

TAB00

NOMESCO Finland

Lumbar puncture

7.6

27.4

D32.00

ICD-10 Finland

Benign tumor of the meninges on the outer surface of the cerebrum

17.8

25.7

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

4.6

25.2

230

R51.80

ICD-10 Finland

Headache

3.4

23.1

127

444

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

3.9

21.7

285

D35.2

ICD-10 Finland

Benign neoplasm: Pituitary gland

21.7

18.8

AAC00

NOMESCO Finland

Ligature of intracranial aneurysm

15.7

18.6

CEC10

NOMESCO Finland

Recession and resection of extraocular muscle

+∞

17.8

AAB10

NOMESCO Finland

Partial excision of intracranial lesion

13.8

17.1

AAB00

NOMESCO Finland

Extirpation of intracranial lesion

13.8

17.1

I63.9

ICD-10 Finland

Cerebral infarction, unspecified

3.0

16.9

110

425

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

10.5

16.6

B01AC04

ATC

clopidogrel; oral

2.6

16.2

131

579

PA2BD

NOMESCO Finland

Extensive CT angiography of brain

8.1

16.1

H50.2

ICD-10 Finland

Vertical strabismus

+∞

15.7

H50.1

ICD-10 Finland

Divergent concomitant strabismus

+∞

15.7

CE2W4

NOMESCO Finland

Eye movement mapping

164.2

15.5

PA2CC

NOMESCO Finland

Cerebral very extensive angiography with X-ray

16.6

15.4

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

3.5

15.3

231

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

3.5

15.2

238

A10AE04

ATC

insulin glargine; parenteral

3.2

14.9

294

AAE10

NOMESCO Finland

Transsphenoidal total or partial excision of intracranial lesion

43.6

14.2

A10AB01

ATC

insulin (human); parenteral (insulins and analog. for injection, fast-acting)

5.5

13.9

G70.0

ICD-10 Finland

Myasthenia gravis

54.7

13.9

ZXD05

NOMESCO Finland

Urgent procedure

2.1

13.5

196

1135

H02AB09

ATC

hydrocortisone; systemic

7.5

12.9

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

3.7

12.7

167

I60.3

ICD-10 Finland

Subarachnoid haemorrhage from posterior communicating artery

132.7

12.5

G51.0

ICD-10 Finland

Bell palsy

6.2

12.4

A10AB04

ATC

insulin lispro; parenteral (insulins and analog. for injection, fast-acting)

5.7

12.3

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.3

12.2

123

602

XCK10

NOMESCO Finland

Photography of fundus of eye

2.8

12.2

322

E23.00

ICD-10 Finland

Panhypopituitarism

21.8

12.1

CS424

NOMESCO Finland

Visual field testing with Goldmann perimetry

13.8

12.0

A10AA01

ATC

6.4

12.0

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

4.2

12.0

113

H53.4

ICD-10 Finland

Visual field defects

6.9

11.9

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.9

11.9

252

1677

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.1

11.8

242

CS444

NOMESCO Finland

Visual field testing with Octopus automated perimetry

4.8

11.6

H49.9

ICD-10 Finland

Paralytic strabismus, unspecified

+∞

11.5

PA2BC

NOMESCO Finland

Cerebral extensive angiography with X-ray

9.2

11.3

A10AA02

ATC

4.8

11.3

H3603, E103

ICD-10 Finland

11.5

11.1

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

3.3

10.9

178

N07AA02

ATC

pyridostigmine; systemic

21.9

10.7

AA4CG

NOMESCO Finland

Extensive MRI examination of sella turcica with high intensity magnet

14.5

10.5

CBJ10

NOMESCO Finland

Fascia plate sling or synthetic material for ptosis correction

+∞

10.4

CEC00

NOMESCO Finland

Recession of extraocular muscle

+∞

10.4

H51.2

ICD-10 Finland

Internuclear ophthalmoplegia

+∞

10.4

CEC30

NOMESCO Finland

Resection of extraocular muscle

+∞

10.4

9530/0-C70.0

ICD-O-3

Meningioma, NOS, of cerebral meninges

12.3

10.4

H47.1

ICD-10 Finland

Papilloedema, unspecified

33.2

10.4

E10.9

ICD-10 Finland

Type 1 diabetes mellitus, Without complications

4.2

10.3

I10

ICD-10 Finland

Essential (primary) hypertension

1.8

10.3

352

2693

D32.9

ICD-10 Finland

Benign neoplasm: Meninges, unspecified

17.1

9.9

C10AA01

ATC

simvastatin; oral

1.8

9.8

273

1947

H3603, E113

ICD-10 Finland

9.8

103

Kela drug reimbursment

Diabetes, insulin-treated

1.9

9.7

175

1082

H3601, E103

ICD-10 Finland

11.6

9.6

E10.3

ICD-10 Finland

Type 1 diabetes mellitus, With ophthalmic complications

5.9

9.6

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.2

9.6

108

551

I69.0

ICD-10 Finland

Sequelae of subarachnoid haemorrhage

10.3

9.6

CA1CG

NOMESCO Finland

Eye and orbita extensive MRI examination with high intensity magnet

17.9

9.4

H47.2

ICD-10 Finland

Optic atrophy

17.9

9.4

A28

ICPC

Limited function/disability NOS

2.1

9.4

111

579

D32.06

ICD-10 Finland

Benign tumor of the meninges os petrosum or clivus area

+∞

9.4

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.8

9.4

262

1860

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

1.9

9.1

154

924

T90.5

ICD-10 Finland

Sequelae of intracranial injury

9.2

9.1

I60.0

ICD-10 Finland

Subarachnoid haemorrhage from carotid siphon and bifurcation

18.9

9.0

H3602, E113

ICD-10 Finland

24.4

8.9

G35

ICD-10 Finland

Multiple sclerosis

8.1

8.9

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

2.6

8.7

278

B01AC30

ATC

platelet aggregation inhibitors excl. heparin - combinations

2.7

8.7

226

157

Kela drug reimbursment

Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)

16.6

8.6

H3601, E113

ICD-10 Finland

6.1

8.5

I63.3

ICD-10 Finland

Cerebral infarction due to thrombosis of cerebral arteries

3.3

8.5

129

H36.00

ICD-10 Finland

Diabetic background retinopathy

7.5

8.5

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

5.2

8.4

I60.9

ICD-10 Finland

Subarachnoid haemorrhage, unspecified

6.0

8.4

N03AX14

ATC

levetiracetam; systemic

4.9

8.3

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

17.5

8.1

108

Kela drug reimbursment

Myasthenia gravis

33.8

8.1

PA2YT

NOMESCO Finland

Cerebral artery PTA with stent

33.8

8.1

N08.39*E11.2

ICD-10 Finland

Non-insulin-dependent diabetes mellitus - Diabetic nephropathy

6.7

7.9

303

Kela drug reimbursment

Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)

13.3

7.9

SPAT1229

SPAT

Assessment of need for aid

2.5

7.8

254

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

15.3

7.7

E10.5

ICD-10 Finland

Type 1 diabetes mellitus, With peripheral circulatory complications

15.3

7.7

A10AE05

ATC

insulin detemir; parenteral

3.0

7.7

156

AAL00

NOMESCO Finland

Endovascular occlusion of intracranial aneurysm

18.6

7.6

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.1

7.6

476

I60.7

ICD-10 Finland

Subarachnoid haemorrhage from intracranial artery, unspecified

25.4

7.6

AA1DM

NOMESCO Finland

Very extensive MRI examination of brain with 3 Tesla magnet

9.0

7.6

E10.00

ICD-10 Finland

Insulin-dependent diabetes diabetic hypoglycemic coma

10.2

7.6

H53.1

ICD-10 Finland

Subjective visual disturbances

2.9

7.5

160

CKC12

NOMESCO Finland

Photocoagulation of retina

3.2

7.4

120

N02BE01

ATC

paracetamol; systemic, rectal

1.8

7.4

478

4197

H50.0

ICD-10 Finland

Convergent concomitant strabismus

81.1

7.4

S04.1

ICD-10 Finland

Injury of oculomotor nerve

81.1

7.4

101

Kela drug reimbursment

Anterior pituitary hypofunction

13.6

7.4

215

Kela drug reimbursment

Diabetes, non-insulin-treated

1.8

7.4

146

916

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

2.0

7.4

528

H36.01

ICD-10 Finland

Diabetic maculopathy

7.0

7.3

CS5Z4

NOMESCO Finland

Specialised imaging for glaucoma

5.3

7.3

F05

ICPC

Visual disturbance other

4.1

7.3

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.6

7.2

212

AA1BD

NOMESCO Finland

Extensive CT of head and brain

4.0

7.2

D32.0

ICD-10 Finland

Benign neoplasm: Cerebral meninges

20.3

7.1

109

Kela drug reimbursment

Multiple sclerosis

8.9

7.1

ZXE30

NOMESCO Finland

More than five and less than seven hours

3.1

7.1

125

E11.3

ICD-10 Finland

Type 2 diabetes mellitus, with ophthalmic complications

3.8

7.1

H36.09*E10.3

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic retinopathy

10.2

7.1

E11.00

ICD-10 Finland

Non-insulin dependent diabetes diabetic hypoglycaemic coma

3.4

7.0

WX408

NOMESCO Finland

General anesthesy, balanced

1.8

7.0

150

964

T90

ICPC

Diabetes non-insulin dependent

1.8

6.9

138

866

Z3229

NOMESCO Finland

Other healthcare associate professional

2.3

6.9

284

CS494

NOMESCO Finland

Other visual field testing

4.8

6.8

G52.8

ICD-10 Finland

Disorders of other specified cranial nerves

40.5

6.8

C08CA01

ATC

amlodipine; oral

1.6

6.7

215

1546

XA800

NOMESCO Finland

Neuropsychological investigation

3.3

6.5

SPAT1263

SPAT

Sampling

1.6

6.5

230

1691

AAF05

NOMESCO Finland

Ventriculoperitoneal shunt

6.3

6.5

2507B

ICD-9 Finland

Diabetes mellitus, Diabetes with peripheral circulatory disorders[DIABETES MELLITUS CUM COMPLICAT ALIA ,TYYPPI I]

70.6

6.4

C03CA01

ATC

furosemide; systemic

1.6

6.4

182

1262

L03AB07

ATC

interferon beta-1a; parenteral

14.5

6.4

PA2LT

NOMESCO Finland

Endovascular closure of extensive brain aneurysm

14.5

6.4

SPAT1301

SPAT

No procedures

1.6

6.4

187

1307

SPAT1262

SPAT

Handing over of treatment supplies

1.8

6.4

115

698

G91.1

ICD-10 Finland

Obstructive hydrocephalus

18.2

6.3

A10BA02

ATC

metformin; oral

1.7

6.2

166

1133

H05.2

ICD-10 Finland

Exophthalmic conditions

27.0

6.2

S06.3

ICD-10 Finland

Focal brain injury

5.4

6.2

25000

ICD-8 Finland

Diabetes mellitus, Sine complicatione

4.1

6.2

E78.01

ICD-10 Finland

Pure hypercholesterolaemia

1.8

6.1

119

741

205

Kela drug reimbursment

Chronic hypertension

1.6

6.1

179

1250

ZXE10

NOMESCO Finland

More than one and less than three hours

1.6

6.1

203

1464

N08.39

ICD-10 Finland

Glomerular disorders in diabetes mellitus microalbuminuria

12.7

6.1

N18

ICPC

Paralysis/weakness

5.0

6.1

H3600, E103

ICD-10 Finland

8.7

6.1

H36.03

ICD-10 Finland

Proliferative diabetic retinopathy

8.7

6.1

XCD10

NOMESCO Finland

Electrophysiological examination of eye

4.0

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_PARASTRA3 and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_PARASTRA3	1.566 [1.37, 1.79]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.183

During the follow-up period (1.1.1998 — 31.12.2019), 692 out of 1999 females with H7_PARASTRA3 died.

Males

Parameter	HR [95% CI]	p-value
H7_PARASTRA3	1.569 [1.36, 1.81]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.022

During the follow-up period (1.1.1998 — 31.12.2019), 689 out of 1924 males with H7_PARASTRA3 died.

Mortality risk

Mortality risk for people of age

years, who have H7_PARASTRA3.

N-year risk	Females	Males
1	0.185%	0.384%
5	0.985%	1.951%
10	2.446%	4.668%
15	4.765%	8.998%
20	8.383%	15.595%

Relationships between endpoints

↥

Index endpoint: H7_PARASTRA3 – Third [oculomotor] nerve palsy

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	H7_PARASTRA3
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H490
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H490
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Third [oculomotor] nerve palsy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints