Third [oculomotor] nerve palsy

H7_PARASTRA3

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H49.0
  • Cause of death: ICD-10 H49.0

2 out of 7 registries used, show all original rules.

668

4. Check minimum number of events

None

668

5. Include endpoints

None

668

6. Filter based on genotype QC (FinnGen only)

646

Control definitions (FinnGen only)

Control exclude
H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H49
Name in latin
Paresis/paralysis nervi oculomotorii

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4483 2283 2171
Only index persons 3953 2021 1932
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.06
Only index persons 0.07 0.07 0.07
Median age at first event (years)
Whole population 65.73 66.58 64.73
Only index persons 64.72 65.45 63.95

-FinnGen-

Key figures

All Female Male
Number of individuals 646 338 308
Unadjusted period prevalence (%) 0.13 0.12 0.14
Median age at first event (years) 62.36 59.05 66.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
668
Matched controls
6680
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H53.2
ICD-10 Finland
Diplopia
49.9
307.7
233
71
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
307.7
668
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
27.7
91.2
63
25
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.1
90.8
160
284
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
85.3
80
*
AA1AD
NOMESCO Finland
CT of head and brain
4.2
72.6
335
1302
XCK00
NOMESCO Finland
Perimetry
6.9
71.2
124
215
H02.4
ICD-10 Finland
Ptosis of eyelid
10.3
68.9
81
88
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.3
68.7
169
404
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
12.5
68.4
70
62
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
12.6
59.3
60
52
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.8
51.3
211
730
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
14.8
47.2
43
31
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
39.9
115
305
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.9
36.9
126
377
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
36.8
35
*
TAB00
NOMESCO Finland
Lumbar puncture
5.5
34.4
71
142
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.5
33.2
135
452
R51.80
ICD-10 Finland
Headache
3.2
31.4
152
565
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
8.9
30.8
39
46
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
10.4
27.6
31
31
A10AB05
ATC
insulin aspart; parenteral
3.7
26.2
90
268
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
8.6
25.4
33
40
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
30.5
24.3
32
11
G51.0
ICD-10 Finland
Bell palsy
6.9
24.1
38
58
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
5.4
23.4
48
95
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.3
22.7
47
94
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
20.4
22.3
33
17
H02AB09
ATC
hydrocortisone; systemic
6.6
22.0
36
57
A10AB01
ATC
insulin (human); parenteral
5.2
21.6
46
94
B01AC04
ATC
clopidogrel; oral
2.5
21.2
169
802
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
18.6
21.1
32
18
A10AC01
ATC
insulin (human); parenteral
3.3
20.9
87
292
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.7
20.5
68
197
A10AA01, ,
ATC
6.1
20.3
36
62
A10AE04
ATC
insulin glargine; parenteral
2.9
19.7
102
388
CE2W4
NOMESCO Finland
Eye movement mapping
108.3
19.7
21
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.9
19.7
45
98
H53.4
ICD-10 Finland
Visual field defects
6.5
19.4
32
51
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.5
19.3
70
215
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
14.7
18.7
31
22
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.3
18.5
49
120
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
17.8
17
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.2
17.4
30
50
PA6AD
NOMESCO Finland
CT of neck arteries
5.1
16.8
36
74
A10AB04
ATC
insulin lispro; parenteral
4.8
16.8
39
86
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
13.1
16.8
29
23
H50.1
ICD-10 Finland
Divergent concomitant strabismus
+∞
16.7
16
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
5.9
16.5
30
53
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
41.2
16.4
20
5
H3603, E103,
ICD-10 Finland
30.9
16.2
21
7
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.0
16.0
78
286
A10AA02, ,
ATC
4.2
15.6
42
104
H50.2
ICD-10 Finland
Vertical strabismus
163.7
15.5
16
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
15.0
158
831
CS494
NOMESCO Finland
Other visual field testing
5.0
14.4
31
64
XCK10
NOMESCO Finland
Photography of fundus of eye
2.6
14.3
93
396
H47.2
ICD-10 Finland
Optic atrophy
30.8
13.9
18
6
E23.00
ICD-10 Finland
Panhypopituitarism
24.4
13.8
19
8
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
5.1
13.7
29
59
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
13.6
57
191
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
13.6
309
2113
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
6.1
13.1
23
39
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
17.1
13.0
20
12
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
13.0
213
1307
N03AX14
ATC
levetiracetam; systemic
4.5
13.0
32
74
CKC12
NOMESCO Finland
Photocoagulation of retina
3.6
13.0
43
124
H3601, E103,
ICD-10 Finland
19.5
13.0
19
10
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.5
13.0
45
134
G70.0
ICD-10 Finland
Myasthenia gravis
23.1
12.9
18
8
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
6.1
12.7
22
37
N07AA02
ATC
pyridostigmine; systemic
16.2
12.2
19
12
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
12.8
11.7
20
16
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
19.3
11.6
17
9
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
11.6
127
674
CEC30
NOMESCO Finland
Resection of extraocular muscle
+∞
11.5
11
*
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
+∞
11.5
11
*
H49.9
ICD-10 Finland
Paralytic strabismus, unspecified
+∞
11.5
11
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
122.0
11.5
12
*
T90.5
ICD-10 Finland
Sequelae of intracranial injury
9.1
11.3
23
26
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.5
11.3
75
322
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
20.4
11.2
16
8
H3601, E113,
ICD-10 Finland
5.1
11.1
23
46
N03AF02
ATC
oxcarbazepine; oral
4.0
11.0
32
84
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
10.9
132
726
F05
ICPC
Visual disturbance other
3.8
10.8
33
90
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
10.8
71
303
L04AX01
ATC
azathioprine; systemic
3.5
10.7
37
110
ZXD05
NOMESCO Finland
Urgent procedure
1.8
10.7
217
1410
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
11.5
10.6
19
17
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.1
10.6
29
73
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
111.7
10.4
11
*
G52.8
ICD-10 Finland
Disorders of other specified cranial nerves
+∞
10.4
10
*
SPAT1229
SPAT
Assessment of need for aid
2.5
10.4
69
296
H04AA01
ATC
glucagon; nasal, parenteral
5.3
10.4
21
41
H36.00
ICD-10 Finland
Diabetic background retinopathy
5.0
10.3
22
45
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
23.8
10.3
14
6
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.8
10.2
189
1191
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.8
10.2
182
1135
XA800
NOMESCO Finland
Neuropsychological investigation
3.3
10.0
37
115
H3602, E113,
ICD-10 Finland
40.7
10.0
12
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.6
9.9
61
252
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
20.4
9.8
14
7
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
4.8
9.8
22
47
C10AA01
ATC
simvastatin; oral
1.7
9.7
316
2325
SPAT1301
SPAT
No procedures
1.7
9.7
218
1451
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
13.6
9.7
16
12
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
8.0
9.7
21
27
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.1
9.6
41
139
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
5.1
9.6
20
40
H36.01
ICD-10 Finland
Diabetic maculopathy
5.3
9.4
19
37
G35
ICD-10 Finland
Multiple sclerosis
8.2
9.4
20
25
S04.1
ICD-10 Finland
Injury of oculomotor nerve
+∞
9.4
9
*
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
22.1
9.4
13
6
SPAT1262
SPAT
Handing over of treatment supplies
1.9
9.3
134
778
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
13.9
9.2
15
11
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
13.9
9.2
15
11
H3603, E113,
ICD-10 Finland
8.5
9.1
19
23
L04AA06
ATC
mycophenolic acid; systemic
4.7
9.1
21
46
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
9.0
321
2403
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.5
9.0
60
258
A28
ICPC
Limited function/disability NOS
1.8
8.9
144
866
N18.8
ICD-10 Finland
Other chronic renal failure
4.0
8.9
25
64
A10AE05
ATC
insulin detemir; parenteral
2.7
8.9
48
186
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.4
8.9
31
93
R42
ICD-10 Finland
Dizziness and giddiness
1.8
8.9
163
1021
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
8.8
429
3468
205
Kela drug reimbursment
Chronic hypertension
1.7
8.8
206
1382
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.2
8.7
35
115
E22.1
ICD-10 Finland
Hyperprolactinaemia
20.3
8.5
12
6
A10AD01
ATC
insulin (human); parenteral
4.4
8.5
21
49
CBJ10
NOMESCO Finland
Fascia plate sling or synthetic material for ptosis correction
91.2
8.4
9
*
NHQ40
NOMESCO Finland
Amputation of toe
4.6
8.4
20
45
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
13.0
8.4
14
11
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
8.3
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
8.2
107
600
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.2
8.2
68
322
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
8.3
8.1
17
21
101
Kela drug reimbursment
Anterior pituitary hypofunction
11.9
8.1
14
12
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
3.7
8.1
25
69
108
Kela drug reimbursment
Myasthenia gravis
22.3
8.0
11
5
T90
ICPC
Diabetes non-insulin dependent
1.7
7.9
170
1108
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
13.2
7.9
13
10
S06.3
ICD-10 Finland
Focal brain injury
6.2
7.9
20
33
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
6.2
7.9
20
33
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.7
7.8
24
66
L28
ICPC
Limited function/disability (L)
1.8
7.8
132
804
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.6
7.8
25
71
H43.1
ICD-10 Finland
Vitreous haemorrhage
3.6
7.8
25
71
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.5
7.7
26
76
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
15.2
7.7
12
8
D32.06
ICD-10 Finland
Benign tumor of the meninges os petrosum or clivus area
45.5
7.7
9
*
CKC10
NOMESCO Finland
Local photocoagulation of retina
4.1
7.7
21
53
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
18.6
7.6
11
6
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
12.0
7.6
13
11
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
12.0
7.6
13
11
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
12.0
7.6
13
11
H57.1
ICD-10 Finland
Ocular pain
3.2
7.5
30
98
C08CA01
ATC
amlodipine; oral
1.6
7.5
269
1992
H50.31
ICD-10 Finland
Intermittent exotropia
81.0
7.4
8
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
7.4
56
255
109
Kela drug reimbursment
Multiple sclerosis
9.5
7.3
14
15
H47.1
ICD-10 Finland
Papilloedema, unspecified
9.5
7.3
14
15
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
15.9
7.2
11
7
TK800
NOMESCO Finland
Hemodialysis
3.8
7.2
22
60
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
7.2
249
1825
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.6
7.1
42
170
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
20.3
7.1
10
5
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.5
7.1
46
195
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
10.2
7.1
13
13
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
10.2
7.1
13
13
A06AD11
ATC
lactulose; oral
1.8
7.0
113
676
K91
ICPC
Cerebrovascular disease
4.4
7.0
17
39
N18
ICPC
Paralysis/weakness
3.8
7.0
21
57
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.6
7.0
187
1288
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.1
6.9
65
323
T89
ICPC
Diabetes insulin dependent
2.8
6.9
33
120
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
8.4
6.9
14
17
C03CA01
ATC
furosemide; systemic
1.6
6.8
228
1652
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
11.1
6.8
12
11
ZXC95
NOMESCO Finland
Use of surgical navigator
6.2
6.8
17
28
Z49.1
ICD-10 Finland
Extracorporeal dialysis
5.8
6.8
18
32
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
7.3
6.7
15
21
CKC15
NOMESCO Finland
Panretinal photocoagulation
7.3
6.7
15
21
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.7
6.5
33
124
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.5
580
5231
H02AB02
ATC
dexamethasone; systemic
1.9
6.5
83
462
N28
ICPC
Limited function/disability (N)
4.0
6.5
18
46
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
6.4
51
237
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.6
6.4
15
23
A10BA02
ATC
metformin; oral
1.6
6.3
201
1436
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.3
6.3
23
71
H49.4
ICD-10 Finland
Progressive external ophthalmoplegia
+∞
6.3
6
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
6.2
114
710
H3600, E103,
ICD-10 Finland
7.8
6.1
13
17
L03AB07
ATC
interferon beta-1a; parenteral
12.7
6.1
10
8
A10AE06
ATC
insulin degludec; parenteral
2.9
6.1
28
100
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.3
6.1
44
197
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
6.0
147
985
PA7BD
NOMESCO Finland
CT angiography of neck and brain
3.9
6.0
17
44

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
72
94
8.46
52.82
1.2
1.4
—
—
—
0
0
47
34
14.79
51.52
1.0
1.1
4.31
1.18
nmol/l
—
12
6
73
115
7.00
45.29
1.4
1.4
1308.13
1051.45
e6/l
0.08
55
94
73
115
7.00
45.29
1.4
1.3
15.31
12.26
e6/l
0.15
54
92
325
1714
2.75
35.73
2.4
2.1
145.65
242.30
u/l
2.77
306
1609
38
40
10.01
32.67
1.3
1.4
—
—
—
0
0
36
38
9.96
30.86
1.1
1.1
49.95
43.45
mg/l
0.18
29
33
198
883
2.77
29.22
1.9
2.1
28.82
29.56
s
1.32
187
850
36
49
7.71
25.25
1.4
1.6
—
—
—
0
0
451
3245
2.20
19.82
8.1
4.9
7.13
6.75
mmol/l
2.99
432
3050
26
32
8.41
19.75
1.8
1.4
—
—
—
0
0
142
658
2.47
18.49
9.5
7.4
1.33
1.37
mmol/l
0.04
118
530
141
662
2.43
17.78
9.6
7.4
5.08
5.12
kpa
0.14
134
635
141
663
2.43
17.72
9.6
7.3
12.59
11.99
kpa
0.61
134
639
91
348
2.87
17.33
2.3
2.5
11.94
21.16
au/ml
—
5
26
348
2422
1.91
14.95
6.9
4.8
34.62
35.24
g/l
1.22
335
2244
106
481
2.43
14.22
1.8
3.2
67.00
66.30
g/l
0.43
97
439
95
418
2.48
13.60
2.1
2.7
9.74
10.58
g/l
1.22
86
385
121
595
2.26
13.47
10.4
7.6
95.60
95.33
%
0.15
116
576
372
2717
1.83
13.05
16.1
16.1
1.17
1.28
inr
1.52
91
767
379
2786
1.83
12.99
11.7
6.9
1.21
1.21
mmol/l
0.41
322
2378
104
497
2.29
12.33
3.3
2.0
352.69
373.15
nmol/l
0.52
97
459
109
539
2.22
11.89
11.0
8.2
119.08
120.00
g/l
0.18
104
528
128
676
2.11
11.82
2.2
1.6
—
—
—
0
0
348
2564
1.75
11.18
11.3
6.1
1.21
1.21
mmol/l
0.76
322
2330
209
1360
1.78
10.16
5.5
4.0
93.38
89.17
%
1.65
202
1323
83
391
2.28
10.12
6.9
4.6
—
—
—
0
0
132
744
1.96
10.08
11.4
5.9
1.09
1.04
mmol/l
1.55
126
684
302
2188
1.69
9.93
4.9
3.8
73.96
38.41
ng/l
0.62
245
1607
244
1670
1.73
9.88
6.8
4.2
7.40
7.40
ph
0.02
47
317
78
363
2.30
9.78
11.9
6.9
25.09
24.61
mmol/l
0.47
73
347
83
406
2.19
9.23
1.6
2.7
—
—
—
0
0
479
4000
1.70
8.52
4.8
4.1
14.53
12.84
mm/h
1.50
443
3654
328
2494
1.62
8.49
8.1
6.2
—
—
—
0
0
213
1455
1.68
8.43
5.5
4.1
0.00
0.00
estimate
-0.00
62
478
342
2633
1.61
8.37
5.0
3.9
0.00
0.00
estimate
0.50
64
539
288
2127
1.62
8.36
4.6
3.6
5.95
5.79
ph
0.19
11
139
244
1730
1.65
8.34
3.1
2.5
54.16
58.79
u/l
0.71
227
1614
371
2921
1.61
8.21
7.0
6.4
10.76
11.80
umol/l
0.96
352
2774
180
1185
1.71
8.13
3.7
2.6
5.01
5.61
e6/l
0.29
159
1070
329
2543
1.58
7.68
3.3
2.6
—
—
—
0
0
341
2661
1.57
7.62
6.9
5.6
0.61
0.59
e9/l
0.82
306
2298
177
1184
1.67
7.45
5.8
4.3
1.02
1.02
kg/l
0.63
22
165
341
2670
1.57
7.44
6.9
5.6
0.04
0.04
e9/l
0.09
305
2312
350
2759
1.56
7.40
7.2
5.8
0.21
0.19
e9/l
1.13
318
2428
291
2206
1.57
7.27
2.7
2.2
73.61
77.82
nmol/l
1.82
264
1950
236
1706
1.59
7.24
3.7
3.3
32.81
32.57
u/l
0.03
223
1618
245
1789
1.58
7.19
3.1
2.4
—
—
—
0
0
239
1737
1.59
7.15
3.8
3.3
—
—
—
0
0
33
119
2.87
7.00
1.5
1.7
4.87
5.37
iu/l
0.08
12
35
87
480
1.93
6.97
12.3
8.4
—
—
—
0
0
131
821
1.74
6.96
3.0
2.0
—
—
—
0
0
384
3118
1.54
6.92
10.5
9.0
4.38
4.17
e9/l
1.08
351
2746
60
290
2.17
6.87
10.6
9.9
—
—
—
0
0
18
44
4.18
6.85
1.1
1.1
—
—
—
0
0
333
2628
1.53
6.79
6.2
5.3
0.00
0.00
estimate
-0.00
64
498
342
2725
1.52
6.60
7.1
5.7
1.85
1.91
e9/l
0.21
308
2414
165
1116
1.64
6.56
1.7
1.7
1267.55
1190.75
nmol/l
0.37
126
842
334
2660
1.51
6.39
5.1
3.9
0.00
0.01
estimate
0.50
62
477
221
1611
1.56
6.38
5.6
4.3
—
—
—
0
0
192
1356
1.58
6.36
3.1
2.4
—
—
—
0
0
21
61
3.52
6.33
1.3
1.3
—
—
—
0
0
9
5
18.22
6.28
1.8
6.0
—
—
—
0
0
483
4183
1.56
6.05
9.8
7.8
81.59
79.32
u/l
0.38
452
3906
225
1670
1.52
5.90
4.1
3.2
921.67
304.45
mg/l
0.69
161
1083
51
247
2.15
5.83
1.9
1.9
3.02
2.74
ug/l
0.06
44
218
176
1241
1.57
5.80
5.0
3.9
—
—
—
0
0
138
922
1.63
5.69
4.1
3.4
0.83
0.81
mmol/l
0.94
130
865
19
56
3.46
5.62
2.8
2.5
1.32
1.50
g/24h
0.11
12
30
230
1742
1.49
5.37
3.9
3.1
6.97
7.55
mmol/l
1.32
189
1447
76
437
1.83
5.37
6.2
4.1
149.38
87.90
ng/l
1.27
71
391
426
3637
1.47
5.34
6.6
4.6
207.79
3532.26
e6/l
1.62
14
68
107
681
1.68
5.32
1.4
1.3
384.76
446.30
titre
0.20
21
146
29
116
2.57
5.11
2.2
1.3
5.68
10.42
u/l
1.85
22
86
89
546
1.73
5.05
6.3
3.9
2.28
1.90
mmol/l
0.46
77
447
12
20
6.09
4.93
2.2
2.4
561.92
903.60
u/ml
0.78
12
20
229
1760
1.46
4.88
4.9
3.8
19.75
8.84
mg/mmol
1.68
157
1118
81
489
1.75
4.87
4.4
3.5
—
—
—
0
0
159
1139
1.52
4.79
3.2
3.1
510.72
549.36
mosm/kgh2o
1.58
137
975
154
1096
1.53
4.78
5.0
4.1
478.29
333.22
ng/l
0.29
126
894
299
2430
1.42
4.64
7.3
5.7
0.63
0.67
%
0.51
286
2258
431
3737
1.43
4.62
5.9
4.4
—
—
—
0
0
86
536
1.69
4.61
2.4
2.4
4.57
6.91
ug/l
1.42
76
467
205
1558
1.46
4.58
3.9
3.3
0.51
0.55
e6/l
0.08
163
1176
251
1982
1.43
4.56
4.9
3.9
80.42
139.92
e6/l
0.75
182
1424
29
123
2.42
4.55
5.5
7.3
103.71
105.11
mmol/l
0.71
24
112
29
123
2.42
4.55
5.5
7.3
10.83
11.13
mmol/l
0.18
24
112
596
5533
1.72
4.54
29.6
18.1
139.41
139.65
mmol/l
1.26
585
5375
305
2502
1.40
4.42
7.3
5.8
2.82
2.86
%
0.14
291
2333
538
4885
1.52
4.40
5.4
4.6
1.90
2.19
mu/l
0.59
496
4405
596
5544
1.70
4.36
30.1
18.3
3.99
3.99
mmol/l
0.07
584
5383
306
2518
1.40
4.33
7.5
6.0
8.73
8.69
%
0.09
293
2354
457
4027
1.43
4.32
4.8
3.8
14.81
14.85
pmol/l
0.12
421
3626
196
1493
1.44
4.28
3.9
3.2
—
—
—
0
0
577
5329
1.61
4.28
24.8
15.5
22.55
25.10
mg/l
1.32
493
4250
286
2330
1.40
4.27
2.1
2.0
92.12
93.43
pmol/l
0.18
144
1207
45
235
1.98
4.27
4.4
5.3
1.60
1.55
%
0.18
39
222
243
1926
1.41
4.26
3.6
3.4
2.37
2.35
mmol/l
1.21
212
1680
167
1236
1.47
4.24
1.8
1.7
466.44
7115449.29
pmol/l
0.50
143
1026
34
162
2.16
4.11
1.1
1.3
0.24
0.23
g/l
0.42
34
153
37
183
2.08
4.07
1.6
4.1
1.39
1.96
ratio
—
5
18
186
1416
1.43
4.05
2.6
2.2
3.07
3.13
mg/l
0.11
161
1209
23
93
2.53
4.00
1.1
1.5
—
—
—
0
0
33
158
2.15
3.95
2.0
1.4
22.88
30.03
iu/l
0.51
28
132
24
100
2.45
3.93
1.4
2.0
3.92
4.68
mmol/24h
0.43
19
87
14
37
3.84
3.91
2.4
1.9
0.19
0.23
e9/l
0.28
14
30
24
101
2.43
3.85
2.6
1.5
—
—
—
0
0
44
237
1.92
3.84
11.2
4.4
—
—
—
0
0
10
19
5.33
3.84
2.4
1.8
—
—
—
0
0
43
231
1.92
3.78
4.5
5.4
0.97
0.87
%
1.07
38
218
15
50
3.05
3.71
1.1
1.2
—
—
—
0
0
26
116
2.29
3.69
5.6
3.9
—
—
—
0
0
29
136
2.18
3.66
1.4
4.5
—
—
—
0
0
34
170
2.05
3.66
1.1
1.3
1.23
1.15
g/l
0.97
34
161
9
266
0.33
3.63
1.4
1.4
—
—
—
0
0
306
2571
1.35
3.59
7.4
5.9
26.15
27.23
%
0.87
293
2410
9
17
5.35
3.52
1.0
1.0
—
—
—
0
0
26
119
2.23
3.49
6.4
4.5
3.49
2.49
mmol/l
0.75
19
81
214
1714
1.37
3.38
4.5
3.4
66.02
94.68
e6/l
0.25
172
1324
95
656
1.52
3.35
1.7
1.4
—
—
—
0
0
224
1809
1.36
3.35
3.5
3.1
1723.13
1588.64
ng/l
0.15
192
1552
33
169
2.00
3.35
5.7
6.7
1.17
1.33
mmol/l
0.63
28
149
177
1377
1.39
3.33
1.6
1.6
21.03
20.39
nmol/l
0.19
154
1154
15
54
2.82
3.27
2.3
2.4
—
—
—
0
0
562
5232
1.47
3.26
5.4
4.7
6.33
6.01
mmol/l
4.33
515
4729
27
131
2.11
3.16
1.4
1.6
—
—
—
0
0
13
40
3.29
3.15
2.3
1.6
—
—
—
0
0
51
307
1.72
3.15
1.3
1.7
—
—
—
0
0
539
4989
1.42
3.14
8.3
6.0
43.76
40.29
mmol/mol
8.53
499
4607
86
591
1.52
3.11
2.1
1.6
—
—
—
0
0
280
2362
1.32
3.05
11.7
9.6
0.00
0.00
e9/l
0.71
242
1934
297
2529
1.31
3.02
7.1
5.7
58.11
57.56
%
0.33
283
2376
77
520
1.54
3.02
2.2
1.5
—
—
—
0
0
5
5
10.06
2.98
1.0
1.6
—
—
—
0
0
386
3411
1.31
2.97
3.7
3.2
58.82
51.55
u/l
0.57
356
3169
8
17
4.75
2.92
1.1
1.1
—
—
—
0
0
6
9
6.71
2.87
1.2
1.0
—
—
—
0
0
8
19
4.25
2.68
1.1
1.1
—
—
—
0
0
179
1439
1.33
2.68
3.9
2.8
342.46
8224.77
umol/l
6.92
164
1247
17
73
2.36
2.67
8.9
5.7
11.18
11.80
mg/l
0.29
17
68
33
184
1.83
2.66
2.1
2.4
21.46
21.57
s
0.06
26
167
70
477
1.52
2.65
3.7
3.1
216.68
232.03
ng/l
0.12
61
437
43
260
1.70
2.64
1.7
2.0
1.57
1.46
g/l
0.28
34
232
7
15
4.70
2.60
6.0
5.3
—
—
—
0
0
7
15
4.70
2.60
1.0
1.0
1911.86
1667.87
miu/ml
—
7
15
72
497
1.50
2.57
1.6
1.4
—
—
—
0
0
5
7
7.19
2.55
4.6
7.4
5.14
5.64
mmol/l
—
5
7
98
720
1.42
2.55
2.1
1.8
—
—
—
0
0
175
1422
1.31
2.41
1.8
1.6
1.34
1.37
mmol/l
0.25
150
1179
103
773
1.39
2.38
4.8
2.5
20.32
22.72
%
0.94
82
660
170
1379
1.31
2.36
6.5
6.9
—
—
—
0
0
116
891
1.37
2.33
4.6
2.5
11.52
12.65
umol/l
1.18
106
826
15
65
2.34
2.33
1.6
2.3
—
—
—
0
0
67
466
1.49
2.32
6.7
3.7
1.23
1.23
mmol/l
0.03
59
405
595
5676
1.44
2.29
14.5
10.7
25.97
25.70
u/l
0.13
572
5461
126
983
1.35
2.29
1.5
1.5
3.28
2.54
g/l
0.69
86
602
168
1367
1.31
2.28
1.4
1.4
—
—
—
0
0
7
18
3.92
2.25
1.4
1.3
—
—
—
0
0
26
143
1.85
2.22
1.5
1.3
—
—
—
0
0
21
110
1.94
2.07
2.6
2.5
16.65
16.08
%
—
10
52
24
133
1.83
2.02
1.3
1.2
—
—
—
0
0
74
541
1.41
2.00
2.6
2.2
0.22
0.21
g/l
0.31
68
508
20
106
1.91
1.92
2.5
3.4
58.45
59.07
%
0.07
20
106
13
58
2.27
1.92
1.2
2.6
—
—
—
0
0
0
50
0.00
1.89
0.0
1.5
—
—
—
0
0
7
22
3.20
1.88
1.1
1.5
—
—
—
0
0
258
2256
1.23
1.88
3.8
2.8
148.19
137.08
ug/l
0.25
235
2066
579
5537
1.34
1.84
23.7
14.3
—
—
—
0
0
5
12
4.19
1.82
1.0
1.1
—
—
—
0
0
19
101
1.91
1.82
1.8
3.0
4.32
4.49
e9/l
0.12
19
101
13
60
2.19
1.78
3.9
2.7
—
—
—
0
0
11
47
2.36
1.78
1.2
1.2
—
—
—
0
0
14
68
2.08
1.71
5.8
4.4
—
—
—
0
0
0
48
0.00
1.70
0.0
1.4
—
—
—
0
0
0
48
0.00
1.70
0.0
1.4
—
—
—
0
0
103
816
1.31
1.70
4.7
2.5
2.16
2.29
g/l
1.52
93
756
150
1783
0.80
1.70
4.3
3.0
—
—
—
0
0
19
105
1.83
1.64
4.2
2.5
—
—
—
0
0
19
106
1.82
1.60
1.3
1.3
89.54
66.31
mmol/l
0.98
13
88
530
5037
1.25
1.57
4.8
4.0
1.39
1.29
mmol/l
2.03
480
4566
62
466
1.36
1.47
4.8
4.1
0.75
1.09
%
0.66
28
181
56
415
1.38
1.45
4.3
4.2
0.50
0.59
%
0.20
22
149
85
672
1.30
1.44
4.2
2.6
1.73
1.80
%
0.36
75
604
5
16
3.14
1.44
1.6
1.0
—
—
—
0
0
6
22
2.74
1.43
1.0
1.0
—
—
—
0
0
132
1103
1.25
1.43
3.0
3.0
2.47
2.45
mmol/l
0.60
115
959
53
390
1.39
1.43
4.4
3.9
7.42
7.40
ph
—
5
39
15
81
1.87
1.41
1.1
1.5
—
—
—
0
0
10
46
2.19
1.40
1.2
1.3
—
—
—
0
0
607
5886
1.34
1.40
35.8
22.6
39.48
39.85
%
0.75
560
5480
607
5886
1.34
1.40
35.3
22.5
252.31
246.45
e9/l
1.38
596
5733
17
96
1.79
1.40
2.8
3.0
—
—
—
0
0
7
29
2.43
1.39
1.0
1.7
—
—
—
0
0
607
5887
1.34
1.39
35.1
22.4
90.73
91.36
fl
3.01
599
5785
607
5888
1.34
1.38
35.1
22.4
30.15
30.38
pg
2.74
599
5784
607
5888
1.34
1.38
35.3
22.5
7.13
6.77
e9/l
2.34
594
5713
6
23
2.62
1.37
1.0
1.0
—
—
—
0
0
58
437
1.36
1.37
4.7
4.2
0.00
0.15
%
4.94
24
151
607
5889
1.34
1.36
35.2
22.5
4.41
4.45
e12/l
1.16
594
5716
607
5891
1.33
1.34
35.4
22.6
131.78
134.41
g/l
3.89
599
5784
165
1422
1.21
1.34
4.6
3.6
—
—
—
0
0
559
5372
1.25
1.33
6.0
5.1
2.53
2.69
mmol/l
3.94
513
4901
543
5204
1.23
1.31
5.4
4.5
1.40
1.46
mmol/l
3.00
495
4746
80
638
1.29
1.29
3.2
2.9
5.77
9.53
umol/l
2.81
69
563
17
99
1.74
1.28
1.9
1.6
—
—
—
0
0
13
70
1.87
1.24
1.4
1.3
—
—
—
0
0
8
36
2.24
1.24
1.0
1.5
—
—
—
0
0
64
498
1.32
1.24
2.6
2.5
64.09
70.74
e9/l
0.89
53
395
58
446
1.33
1.22
5.2
3.8
—
—
—
0
0
5
19
2.64
1.22
4.8
3.8
53.30
50.71
%
—
5
19
546
5248
1.22
1.21
5.5
4.5
4.39
4.60
mmol/l
4.63
500
4818
51
386
1.35
1.19
2.8
2.3
9.67
12.91
nmol/l
2.00
45
341
16
94
1.72
1.18
2.6
2.2
196.17
3642.10
u/l
—
6
29
31
215
1.46
1.18
3.4
3.5
0.52
0.24
g/l
0.71
15
91
31
216
1.46
1.15
2.5
1.9
—
—
—
0
0
14
80
1.77
1.13
1.3
1.4
—
—
—
0
0
40
294
1.38
1.12
4.6
4.0
—
—
—
0
0
27
185
1.48
1.10
10.1
10.6
—
—
—
0
0
217
1954
1.16
1.05
5.3
5.1
9.38
2.72
ug/l
0.44
193
1731
23
156
1.49
0.99
3.2
2.4
199.71
100.07
ug/min
0.53
14
88
52
407
1.30
0.99
4.2
4.3
0.06
0.85
%
0.55
17
120
14
84
1.68
0.98
1.2
1.1
81.80
16.18
iu/ml
—
5
17
14
84
1.68
0.98
3.9
3.2
—
—
—
0
0
5
23
2.18
0.98
4.2
2.3
—
—
—
0
0
10
54
1.86
0.97
1.2
1.1
—
—
—
0
0
11
62
1.79
0.94
1.4
1.5
60.17
58.85
%
—
6
48
7
37
1.90
0.94
2.0
3.2
—
—
—
0
0
475
4546
1.16
0.94
29.1
18.3
15.35
15.20
%
0.22
467
4476
43
331
1.32
0.93
1.6
1.4
—
—
—
0
0
42
323
1.32
0.92
1.4
1.2
268.12
158.52
iu/ml
0.65
18
130
6
28
2.15
0.91
1.8
1.1
205.83
662.65
u/l
—
6
23
15
94
1.61
0.91
8.4
2.9
—
—
—
0
0
6
29
2.08
0.89
1.3
12.9
—
—
—
0
0
42
535
0.77
0.88
1.4
1.6
—
—
—
0
0
23
161
1.44
0.87
5.3
3.2
—
—
—
0
0
28
378
0.73
0.87
1.2
1.4
—
—
—
0
0
41
318
1.31
0.86
5.4
2.8
0.17
0.32
e6/l
1.12
41
312
188
1700
1.15
0.85
4.1
4.0
—
—
—
0
0
8
47
1.71
0.81
1.6
1.2
—
—
—
0
0
6
33
1.83
0.79
1.0
1.5
1.17
3.22
u/field
—
6
23
11
67
1.65
0.75
34.0
6.3
8.45
6.94
mmol/l
0.77
11
55
14
208
0.67
0.75
1.5
1.7
—
—
—
0
0
6
106
0.56
0.73
1.0
1.6
—
—
—
0
0
5
25
2.01
0.73
5.6
5.3
—
—
—
0
0
30
384
0.77
0.68
1.2
1.3
—
—
—
0
0
232
2159
1.11
0.66
2.3
2.1
—
—
—
0
0
14
95
1.48
0.64
7.6
3.6
1.00
1.40
%
0.34
14
86
8
51
1.58
0.60
1.3
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.6
—
29.78
—
0
23
6
35
1.72
0.58
1.0
1.1
—
—
—
0
0
19
141
1.36
0.57
2.0
1.7
34.95
41.43
nmol/l
0.84
19
134
6
37
1.63
0.55
2.2
2.5
—
—
—
0
0
6
37
1.63
0.55
1.0
2.4
6.05
4.08
umol/l
—
6
25
43
359
1.21
0.54
3.9
3.1
—
—
—
0
0
9
61
1.48
0.54
1.6
1.2
—
—
—
0
0
6
40
1.50
0.51
1.5
2.0
—
—
—
0
0
82
728
1.14
0.51
1.3
1.2
—
—
—
0
0
12
167
0.71
0.49
1.1
1.2
—
—
—
0
0
102
922
1.13
0.49
3.2
3.1
5.80
2.12
e6/l
0.97
52
517
397
3839
1.08
0.46
4.7
4.0
—
—
—
0
0
39
331
1.19
0.44
1.2
1.2
—
—
—
0
0
8
56
1.43
0.42
1.8
1.3
—
—
—
0
0
8
58
1.38
0.41
5.8
3.0
—
—
—
0
0
5
33
1.52
0.41
2.6
2.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.9
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
8
59
1.36
0.41
8.5
3.5
55.69
53.88
%
—
8
52
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
11
79
1.40
0.41
1.2
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
39.76
—
0
11
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
2.0
1.4
1.02
1.04
g/l
—
5
34
0
18
0.00
0.40
0.0
1.3
—
42.18
—
0
10
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.2
1.6
8.40
10.44
mmol/l
—
5
36
28
234
1.21
0.38
1.1
1.2
—
—
—
0
0
9
68
1.33
0.37
1.2
1.1
—
—
—
0
0
13
169
0.76
0.37
1.7
1.6
—
—
—
0
0
75
680
1.12
0.36
1.4
1.3
—
—
—
0
0
76
835
0.90
0.36
1.3
1.2
1.10
11.63
u/ml
4.65
24
312
5
77
0.65
0.36
1.4
1.7
33.00
33.31
pg
—
5
77
9
122
0.73
0.35
1.2
1.4
—
—
—
0
0
42
367
1.15
0.35
1.2
1.2
—
—
—
0
0
6
44
1.37
0.34
1.3
1.0
—
—
—
0
0
42
477
0.87
0.34
1.5
1.5
—
—
—
0
0
34
294
1.16
0.33
2.4
2.4
—
—
—
0
0
7
97
0.72
0.31
1.0
1.2
—
—
—
0
0
7
53
1.32
0.31
1.1
1.2
—
—
—
0
0
125
1177
1.08
0.29
1.7
1.8
1.27
1.25
mg/l
0.05
93
919
13
103
1.27
0.28
2.1
1.8
154.46
237.72
pmol/l
2.02
13
96
8
64
1.25
0.27
1.0
1.1
1.43
1.51
g/l
—
8
59
9
121
0.74
0.27
1.2
1.4
—
—
—
0
0
9
121
0.74
0.27
1.2
1.4
—
—
—
0
0
9
121
0.74
0.27
1.2
1.4
—
—
—
0
0
10
77
1.30
0.26
1.5
1.2
—
—
—
0
0
9
72
1.25
0.25
1.2
1.9
—
—
—
0
0
16
133
1.21
0.24
1.3
1.6
7646.90
20132.13
e6/l
—
10
100
6
83
0.72
0.24
1.7
1.8
—
—
—
0
0
26
228
1.15
0.23
1.0
1.1
—
95.86
—
0
7
116
1101
1.06
0.23
1.3
1.2
0.99
1.71
u/ml
0.72
30
288
0
11
0.00
0.21
0.0
1.3
—
1.70
—
0
11
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.2
—
7316.20
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
4.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
9
112
0.80
0.20
1.2
1.4
—
—
—
0
0
60
560
1.08
0.19
6.5
4.3
—
—
—
0
0
55
514
1.08
0.17
3.3
2.3
32.87
31.89
u/l
0.08
46
426
7
62
1.13
0.17
1.9
1.3
0.79
0.56
nmol/l
—
7
55
5
68
0.73
0.17
1.6
1.6
—
—
—
0
0
84
881
0.95
0.16
1.3
1.2
31.42
38.53
iu/ml
0.20
16
280
39
361
1.09
0.15
2.5
2.7
4.63
7.65
e9/l
0.87
32
290
18
198
0.91
0.11
1.1
1.1
—
—
—
0
0
14
126
1.11
0.09
5.2
2.9
—
—
—
0
0
6
56
1.07
0.08
1.2
1.2
—
—
—
0
0
6
58
1.03
0.08
2.0
1.3
—
—
—
0
0
57
592
0.96
0.08
1.9
2.2
155.58
137.97
ug/g
0.13
46
460
5
62
0.80
0.08
1.0
1.3
—
—
—
0
0
15
164
0.91
0.08
1.1
1.1
—
—
—
0
0
9
85
1.06
0.07
1.2
1.1
—
—
—
0
0
9
88
1.02
0.07
1.1
2.8
—
—
—
0
0
30
285
1.06
0.06
4.6
4.0
—
—
—
0
0
38
396
0.96
0.06
1.5
1.4
—
—
—
0
0
61
595
1.03
0.04
1.3
1.3
—
—
—
0
0
15
160
0.94
0.04
1.5
1.4
247.75
296.13
ug/g
—
8
92
17
162
1.05
0.02
4.6
5.0
—
—
—
0
0
14
133
1.05
0.01
3.6
2.6
—
—
—
0
0
14
134
1.05
0.00
6.5
4.1
28.31
28.92
mg/l
—
8
85
25
244
1.03
0.00
2.7
3.3
18.40
5604.77
u/ml
0.77
20
212
62
626
0.99
0.00
3.3
4.1
9.60
31.53
ug/l
0.89
53
525
14
135
1.04
0.00
1.2
1.3
—
—
—
0
0
10
96
1.04
0.00
1.3
1.5
—
—
—
0
0
14
143
0.98
0.00
1.0
1.1
—
—
—
0
0
29
286
1.01
0.00
1.3
1.2
—
—
—
0
0
24
242
0.99
0.00
3.2
2.9
—
—
—
0
0
12
119
1.01
0.00
1.2
1.2
—
—
—
0
0
114
1138
1.00
0.00
2.8
3.0
0.69
0.79
ug/l
0.89
81
771
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
47.00
—
0
5
5
51
0.98
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.2
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
41.63
—
0
8
0
9
0.00
-0.00
0.0
1.0
—
18.27
—
0
9
5
56
0.89
-0.00
1.2
2.4
1.60
2.71
u/field
—
5
21
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
9
92
0.98
-0.00
1.2
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
65
0.92
-0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_PARASTRA3 and mortality.

Females

Parameter HR [95% CI] p-value
H7_PARASTRA3 1.566 [1.37, 1.79] < 0.001
Birth year 0.994 [0.99, 1.0] 0.183

During the follow-up period (1.1.1998 — 31.12.2019), 692 out of 1999 females with H7_PARASTRA3 died.

Males

Parameter HR [95% CI] p-value
H7_PARASTRA3 1.569 [1.36, 1.81] < 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 689 out of 1924 males with H7_PARASTRA3 died.

Mortality risk

Mortality risk for people of age

years, who have H7_PARASTRA3.

N-year risk Females Males
1 0.185% 0.384%
5 0.985% 1.951%
10 2.446% 4.668%
15 4.765% 8.998%
20 8.383% 15.595%

Relationships between endpoints

Index endpoint: H7_PARASTRA3 – Third [oculomotor] nerve palsy

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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