obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
158 |
4. Check minimum number of eventsNone |
158 |
5. Include endpointsNone |
158 |
6. Filter based on genotype QC (FinnGen only) |
158 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L81
- Name in latin
- Chloasma
Similar endpoints
↥List of similar endpoints to
Chloasma
based on the number of shared cases.
Similar with more cases:
- Other disorders of pigmentation
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 918 | 754 | 148 |
| Only index persons | 851 | 720 | 131 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.00 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 47.29 | 48.22 | 43.92 |
| Only index persons | 47.24 | 48.03 | 42.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 158 | 136 | 22 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.01 |
| Median age at first event (years) | 47.97 | 48.46 | 44.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 139
- Matched controls
- 1391
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.1
ICD-10 Finland
Chloasma
7630.7
156.1
120
*
L57.0
ICD-10 Finland
Actinic keratosis
6.7
10.1
26
46
7090A
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Dyschromia[CHLOASMA]
+∞
7.4
7
*
L82
ICD-10 Finland
Seborrhoeic keratosis
3.7
7.3
33
107
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
73.1
6.5
7
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
100
750
1.91
3.68
9.2
9.1
3.6
4.0
e9/l
1.39
91
660
62
403
1.89
3.54
1.9
2.3
55.4
55.9
u/l
0.05
57
365
62
413
1.82
3.22
4.6
2.9
—
—
—
0
0
72
512
1.75
2.94
2.2
1.8
102.3
97.8
pmol/l
0.37
39
250
89
677
1.72
2.82
5.2
5.3
9.0
9.9
umol/l
0.81
82
633
17
73
2.49
2.76
1.0
1.1
—
—
—
0
0
49
318
1.78
2.71
1.4
1.2
0.6
1.6
u/ml
0.82
12
85
25
131
2.08
2.59
25.2
18.9
1.1
1.2
inr
—
7
28
81
620
1.63
2.36
6.8
5.7
1.2
1.2
mmol/l
1.69
72
516
93
737
1.64
2.36
3.0
3.7
6.0
6.4
mmol/l
2.08
86
663
18
86
2.23
2.33
2.8
3.4
0.5
2.2
mmol/l
0.80
13
70
48
322
1.70
2.33
2.2
2.5
587.4
927.8
ng/l
1.29
39
268
6
13
4.75
2.29
1.5
1.3
—
—
—
0
0
6
13
4.75
2.29
1.5
1.3
—
—
—
0
0
19
94
2.16
2.27
1.7
1.4
—
—
—
0
0
120
1025
1.71
2.17
4.7
3.8
10.9
11.2
mm/h
0.16
114
944
23
125
1.98
2.16
1.7
1.6
—
—
—
0
0
15
70
2.26
2.06
1.5
1.4
—
—
—
0
0
30
182
1.80
2.04
1.5
1.7
—
—
—
0
0
82
649
1.55
1.96
3.8
3.4
0.0
0.0
estimate
0.00
15
112
62
462
1.56
1.93
2.3
3.1
12.6
35.5
ng/l
1.60
35
303
7
22
3.28
1.90
2.0
1.2
—
—
—
0
0
7
22
3.28
1.90
2.0
1.2
—
—
—
0
0
43
295
1.63
1.88
1.8
2.0
—
—
—
0
0
122
1063
1.65
1.87
4.3
4.1
14.2
14.6
pmol/l
1.50
113
978
150
1402
2.38
1.84
16.9
13.5
71.0
71.3
umol/l
0.08
150
1402
5
12
4.26
1.83
2.2
1.9
4.9
3.9
nmol/l
—
5
12
76
599
1.52
1.81
3.6
3.7
—
—
—
0
0
35
231
1.66
1.77
3.5
3.1
34.0
272.3
ng/l
1.34
23
162
6
18
3.42
1.76
1.3
1.9
—
—
—
0
0
80
643
1.49
1.70
5.3
4.7
0.0
0.0
estimate
0.00
15
117
28
176
1.72
1.69
2.9
2.8
2.8
2.9
e6/l
0.03
19
91
79
636
1.48
1.66
3.7
3.4
0.0
0.0
estimate
0.00
14
118
21
123
1.82
1.60
1.7
1.6
—
—
—
0
0
71
567
1.46
1.52
5.6
4.8
1.2
1.2
mmol/l
1.50
62
504
35
241
1.58
1.50
2.6
2.6
2.4
2.4
mmol/l
0.32
29
215
9
43
2.16
1.32
2.2
1.7
—
—
—
0
0
15
84
1.87
1.32
1.6
1.4
—
—
—
0
0
103
896
1.43
1.31
3.2
3.3
—
—
—
0
0
10
48
2.16
1.30
2.2
1.4
—
—
—
0
0
76
629
1.40
1.28
2.7
2.7
87.0
79.0
ug/l
0.28
71
581
17
101
1.77
1.26
2.9
2.2
61.6
65.5
ml/min/173m2
—
10
40
8
38
2.16
1.20
2.9
3.6
39.6
51.9
%
—
8
38
11
57
2.00
1.20
2.4
1.4
—
—
—
0
0
22
143
1.63
1.19
6.0
4.8
—
—
—
0
0
8
39
2.11
1.17
1.3
1.4
—
—
—
0
0
132
1217
1.51
1.12
5.3
5.1
37.6
38.9
mmol/mol
1.73
126
1131
136
1262
1.56
1.11
5.6
4.8
2.0
1.8
mu/l
0.93
131
1154
5
22
2.31
1.04
1.0
1.5
—
—
—
0
0
7
35
2.05
1.01
1.4
1.4
—
—
—
0
0
142
1337
1.61
1.01
15.5
11.6
17.5
19.3
mg/l
0.30
123
1017
134
1247
1.49
1.00
13.8
11.2
82.9
82.4
ml/min/173m2
0.10
117
1000
26
184
1.49
1.00
2.7
2.6
1.2
0.8
e6/l
0.27
17
99
41
322
1.37
0.91
1.8
1.5
—
—
—
0
0
56
465
1.32
0.86
3.5
3.0
2.4
2.4
mmol/l
0.07
46
409
6
31
1.97
0.85
1.5
1.1
—
—
—
0
0
138
1302
1.47
0.84
5.0
4.3
5.6
5.8
mmol/l
1.04
131
1201
8
47
1.74
0.82
1.0
1.8
—
—
—
0
0
20
140
1.49
0.82
2.8
3.9
3.1
10.3
ug/l
1.29
15
109
8
48
1.70
0.80
1.0
1.8
—
—
—
0
0
0
26
0.00
0.79
0.0
1.5
—
7.0
—
0
18
7
38
1.88
0.74
2.4
2.0
—
—
—
0
0
11
68
1.66
0.74
5.6
3.1
5.0
5.1
kpa
0.18
11
61
5
25
2.03
0.73
1.6
1.2
—
—
—
0
0
5
26
1.95
0.71
1.0
1.1
—
—
—
0
0
38
308
1.31
0.69
1.5
1.5
18.9
22.2
nmol/l
0.88
32
258
5
29
1.75
0.64
1.0
1.2
—
5.3
—
0
11
141
1349
1.42
0.64
5.4
4.7
3.0
2.8
mmol/l
1.15
136
1240
8
49
1.67
0.63
2.8
2.4
1.1
0.9
%
—
8
49
16
114
1.45
0.61
2.6
3.3
201.8
237.6
u/l
1.71
16
108
11
72
1.57
0.61
1.4
1.3
34.6
29.0
iu/l
0.20
11
65
58
505
1.23
0.59
4.0
3.3
—
—
—
0
0
8
54
1.51
0.58
2.0
1.2
—
—
—
0
0
37
306
1.27
0.58
1.7
1.6
0.7
1.1
mg/l
1.07
30
241
10
65
1.57
0.57
1.5
1.6
—
—
—
0
0
15
108
1.43
0.55
4.9
4.0
18.9
21.2
%
—
7
43
39
329
1.25
0.52
3.4
2.8
0.1
0.6
e6/l
1.89
33
246
18
137
1.35
0.50
6.7
4.7
2.1
1.8
ug/l
0.14
18
119
137
1319
1.29
0.46
4.9
4.2
1.5
1.6
mmol/l
1.19
132
1216
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
5
34
1.49
0.40
1.0
1.2
—
—
—
0
0
31
263
1.22
0.40
1.5
1.3
12.1
32.8
iu/ml
—
6
93
11
82
1.37
0.35
3.1
2.8
0.7
0.7
ug/l
—
5
49
43
384
1.16
0.32
1.7
1.6
1.4
1.4
mmol/l
0.04
37
327
7
98
0.70
0.32
3.1
3.7
1.2
1.2
mmol/l
—
7
83
38
341
1.15
0.27
4.1
3.4
0.0
0.0
estimate
0.00
15
116
5
37
1.36
0.24
1.2
1.3
—
—
—
0
0
11
134
0.81
0.21
1.9
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
13
108
1.22
0.21
1.3
1.2
89.6
187.9
iu/ml
—
7
47
33
303
1.11
0.17
2.8
2.4
331.9
4410.4
umol/l
1.31
27
260
130
1275
1.11
0.15
4.4
3.8
1.2
1.2
mmol/l
0.03
124
1165
7
85
0.82
0.15
1.4
1.4
—
—
—
0
0
18
161
1.13
0.13
1.4
1.9
—
—
—
0
0
5
44
1.14
0.10
2.0
1.7
—
—
—
0
0
6
53
1.14
0.09
1.0
1.8
35.7
39.5
u/l
—
6
47
125
1233
1.07
0.08
16.0
12.8
38.3
39.8
%
0.88
92
930
7
81
0.86
0.07
1.1
1.5
—
—
—
0
0
16
149
1.08
0.05
1.3
1.8
—
—
—
0
0
27
279
0.96
0.02
1.5
1.5
—
—
—
0
0
16
152
1.06
0.02
1.7
1.4
1.5
1.3
%
0.58
11
125
12
121
0.99
0.00
3.0
3.2
—
—
—
0
0
26
259
1.00
0.00
1.5
1.3
20.2
6.2
u/ml
0.32
11
104
0
5
0.00
0.00
0.0
1.6
—
500.4
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
2.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
134.0
—
0
6
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
5.7
—
213.8
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
0.00
0.0
8.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_CHLOASMA and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_CHLOASMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_CHLOASMA – Chloasma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data