No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
206 |
4. Check minimum number of eventsNone |
206 |
5. Include endpointsNone |
206 |
6. Filter based on genotype QC (FinnGen only) |
206 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M24
- Name in latin
- Ancylosis articulationis
Similar endpoints
↥List of similar endpoints to
Ankylosis of joint
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2284 | 1149 | 1101 |
| Only index persons | 1575 | 851 | 724 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.86 | 50.73 | 50.88 |
| Only index persons | 45.49 | 46.78 | 43.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 206 | 107 | 99 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 46.31 | 45.20 | 47.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 190
- Matched controls
- 1899
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M24.6
ICD-10 Finland
Ankylosis of joint
+∞
97.5
85
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
36.3
36.8
47
17
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
28.9
27
*
72710
ICD-8 Finland
Ankylosis of joint, Of shoulder
+∞
27.8
26
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
149.6
25.3
26
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
20.3
17.0
25
14
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
49.4
15.3
18
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
11.9
14.8
27
26
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
29.9
14.6
19
7
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
53.9
13.0
15
*
72700
ICD-8 Finland
Ankylosis of joint, Of spine
+∞
12.6
12
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
50.0
12.0
14
*
M09AX01
ATC
hyaluronic acid; parenteral
23.1
10.9
15
7
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
9.7
10.6
21
24
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
10.5
10
*
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
10.5
10
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
+∞
10.5
10
*
NGT60
NOMESCO Finland
Forcible manipulation of knee joint
+∞
10.5
10
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.5
10.1
53
188
N03AX12
ATC
gabapentin; oral
4.5
9.7
35
90
72799
ICD-8 Finland
Ankylosis of joint, Of unspecified site
+∞
9.4
9
*
NF1AA
NOMESCO Finland
Hip X-ray examination
6.4
8.9
23
40
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
52.4
8.8
10
*
B01AB05
ATC
enoxaparin; parenteral
2.9
8.7
60
257
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.1
8.6
34
96
NDE60
NOMESCO Finland
Incision and release of adhesions in joint of finger or metacarpal
94.0
8.5
9
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
94.0
8.5
9
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
8.3
84
449
M01AX05
ATC
glucosamine; oral
3.5
8.3
40
133
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
35.0
8.2
10
*
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
15.9
7.8
12
8
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
10.7
7.7
14
14
M25.5
ICD-10 Finland
Pain in joint
3.3
7.6
41
146
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
7.5
67
331
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
7.4
7.5
17
25
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
+∞
7.3
7
*
72770
ICD-8 Finland
Ankylosis of joint, Of ankle
+∞
7.3
7
*
L15
ICPC
Knee symptom/complaint
3.5
7.3
34
110
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
7.1
7.3
17
26
N02AX02
ATC
tramadol; systemic, rectal
2.4
7.2
80
443
L90
ICPC
Osteoarthrosis of knee
14.5
7.0
11
8
M20.1
ICD-10 Finland
Hallux valgus (acquired)
14.5
7.0
11
8
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.7
6.9
54
247
9253
FHL
Manipulation under anesthesia or regression and plastering
23.5
6.7
9
*
M48.0
ICD-10 Finland
Spinal stenosis
4.0
6.6
26
73
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
15.0
6.5
10
7
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
15.0
6.5
10
7
J01DA01
ATC
[U] cefalexin; systemic
2.2
6.5
119
820
M01AH05
ATC
etoricoxib; oral
2.2
6.4
91
556
R51.80
ICD-10 Finland
Headache
3.2
6.4
33
116
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
11.6
6.4
11
10
R07.4
ICD-10 Finland
Chest pain, unspecified
2.5
6.4
57
280
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
6.3
6
*
72760
ICD-8 Finland
Ankylosis of joint, Of knee
+∞
6.3
6
*
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
+∞
6.3
6
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
27.7
6.3
8
*
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
13.1
6.2
10
8
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
13.1
6.2
10
8
1220
FHL
Arthroscopy
10.5
6.1
11
11
M01AH01
ATC
celecoxib; oral (coxibs)
3.0
6.1
37
143
M01AX17
ATC
nimesulide; oral
2.5
6.0
49
228
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
140
2.71
5.91
1.2
1.1
1.2
1.3
u/ml
—
7
60
88
579
1.91
4.78
2.4
2.2
74.3
76.4
nmol/l
0.25
76
507
35
166
2.34
4.52
1.3
1.2
11.8
16.1
iu/ml
0.54
11
52
101
745
1.70
3.44
6.2
6.1
1.2
1.2
mmol/l
0.55
88
638
128
1010
1.71
3.36
4.1
3.4
13.8
12.2
mm/h
0.53
118
914
79
570
1.63
2.79
2.3
1.9
84.1
92.4
pmol/l
0.88
38
294
61
417
1.66
2.64
2.6
2.1
291.0
228.2
u/l
0.21
56
393
85
633
1.58
2.60
4.6
4.2
35.4
35.2
g/l
0.14
79
591
31
179
1.86
2.39
9.1
8.4
—
—
—
0
0
45
295
1.67
2.27
1.3
1.2
11.1
1.0
u/ml
0.67
11
79
8
24
3.42
2.20
1.4
1.3
—
—
—
0
0
46
307
1.64
2.16
2.6
2.6
370.2
15420.3
umol/l
3.10
38
258
28
166
1.79
2.00
2.4
2.2
18.2
23.9
%
1.85
23
138
73
556
1.48
1.91
2.8
2.4
147.0
116.0
ug/l
0.58
66
505
49
343
1.56
1.89
2.1
1.8
2.5
3.2
mg/l
1.39
41
290
61
452
1.50
1.81
3.0
3.0
1637.3
1446.6
ng/l
0.19
53
386
40
272
1.58
1.74
1.4
1.5
0.7
1.2
mg/l
1.64
35
203
124
1062
1.42
1.66
4.9
3.7
15.3
14.9
pmol/l
0.93
112
952
76
614
1.38
1.37
3.9
3.6
—
—
—
0
0
5
18
2.82
1.29
1.0
1.9
—
—
—
0
0
148
1345
1.36
1.16
6.0
5.8
39.7
40.6
mmol/mol
0.62
140
1228
70
579
1.32
1.05
5.1
3.9
35.7
52.6
ng/l
0.56
57
429
42
321
1.39
1.04
2.3
2.2
—
—
—
0
0
5
22
2.30
1.04
1.0
1.2
—
—
—
0
0
0
31
0.00
0.97
0.0
1.5
—
—
—
0
0
27
197
1.43
0.88
6.2
4.1
35.0
31.8
%
0.53
21
130
6
31
1.96
0.85
1.0
2.1
—
—
—
0
0
105
935
1.25
0.84
3.4
2.8
56.0
47.4
u/l
0.42
96
860
6
32
1.90
0.82
1.2
1.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
12.3
—
0
17
37
291
1.33
0.78
1.9
1.6
1127.4
1178.5
nmol/l
0.14
29
221
42
338
1.30
0.76
1.7
1.5
27.5
20.7
nmol/l
0.62
36
275
9
54
1.70
0.75
1.7
1.8
—
—
—
0
0
9
54
1.70
0.75
1.0
1.9
—
—
—
0
0
91
805
1.23
0.75
2.5
2.7
—
—
—
0
0
97
864
1.23
0.75
3.9
4.4
6.4
6.9
mmol/l
1.43
90
816
123
1124
1.23
0.75
6.9
7.0
78.4
82.3
u/l
0.41
118
1050
45
368
1.29
0.73
1.5
1.6
1.5
1.3
mmol/l
0.82
39
291
90
800
1.22
0.70
6.6
8.7
4.4
4.2
e9/l
0.46
76
686
13
86
1.55
0.68
1.5
1.6
—
—
—
0
0
7
44
1.61
0.66
1.1
1.1
—
—
—
0
0
7
44
1.61
0.66
1.1
1.1
—
—
—
0
0
5
30
1.68
0.62
1.0
1.3
—
—
—
0
0
30
238
1.30
0.61
1.7
1.8
—
—
—
0
0
0
21
0.00
0.60
0.0
3.5
—
—
—
0
0
84
754
1.19
0.57
5.0
6.3
9.9
12.5
umol/l
2.23
79
722
141
1326
1.20
0.56
5.9
4.3
1.9
2.8
mu/l
0.53
130
1190
6
37
1.64
0.56
1.7
1.5
—
—
—
0
0
14
99
1.44
0.55
5.9
3.1
1.4
1.9
mmol/l
—
9
79
7
45
1.57
0.49
1.0
4.2
53.2
50.7
mg/l
—
7
40
5
84
0.59
0.46
2.0
2.8
1.7
1.3
%
—
5
84
21
167
1.29
0.44
1.6
1.7
—
—
—
0
0
5
31
1.63
0.43
1.2
1.6
—
—
—
0
0
27
323
0.81
0.42
3.6
2.8
1.0
0.9
ug/l
0.02
18
211
29
242
1.23
0.42
2.2
2.7
1.4
1.7
e6/l
0.11
17
125
8
59
1.37
0.41
1.8
2.0
—
—
—
0
0
8
59
1.37
0.41
1.3
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
5
34
1.48
0.40
1.2
1.6
—
—
—
0
0
21
169
1.27
0.40
1.7
1.8
—
—
—
0
0
50
562
0.85
0.40
4.5
3.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
11
80
1.40
0.39
1.9
1.4
—
—
—
0
0
5
36
1.40
0.38
1.0
1.5
—
—
—
0
0
5
36
1.40
0.38
1.0
1.5
—
—
—
0
0
14
107
1.33
0.38
2.6
3.1
68.0
65.0
ml/min/173m2
—
5
45
59
533
1.15
0.36
2.7
3.1
—
—
—
0
0
151
1453
1.15
0.35
17.4
13.5
24.4
26.5
mg/l
0.33
120
1111
158
1525
1.15
0.34
19.6
15.9
139.9
139.6
mmol/l
0.73
153
1474
158
1526
1.15
0.34
19.8
16.0
4.0
4.0
mmol/l
0.43
153
1472
29
249
1.19
0.33
2.2
2.6
0.5
1.1
e6/l
1.34
17
131
15
121
1.26
0.29
1.2
1.4
—
—
—
0
0
32
281
1.16
0.28
3.6
3.5
129.3
200.8
ng/l
0.26
27
226
8
67
1.20
0.26
1.4
1.2
—
—
—
0
0
10
77
1.31
0.26
1.0
1.0
—
—
—
0
0
20
170
1.20
0.25
1.4
1.4
—
—
—
0
0
147
1425
1.11
0.24
4.8
4.4
5.9
6.0
mmol/l
0.39
133
1294
146
1417
1.10
0.23
4.7
4.3
1.5
1.5
mmol/l
0.20
136
1286
67
714
0.91
0.23
4.6
5.0
0.0
0.0
estimate
—
8
125
5
39
1.29
0.23
1.8
2.4
23.9
25.2
mmol/l
—
5
34
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
236.2
—
0
11
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
5.3
—
118.5
—
0
10
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
4.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
150
1464
1.09
0.18
5.2
4.9
2.6
2.7
mmol/l
0.95
141
1328
147
1435
1.09
0.17
4.7
4.3
4.5
4.6
mmol/l
0.65
141
1318
159
1558
1.09
0.17
18.4
16.1
84.5
80.0
umol/l
0.52
159
1558
6
78
0.76
0.16
7.7
7.3
26.0
24.3
mmol/l
—
6
73
69
721
0.94
0.14
3.9
3.6
0.0
0.0
estimate
—
10
123
139
1362
1.06
0.12
4.2
3.9
1.3
1.2
mmol/l
0.56
130
1232
16
178
0.89
0.12
5.1
5.6
5.1
5.0
kpa
0.19
16
167
16
178
0.89
0.12
5.1
5.6
11.1
11.6
kpa
0.29
16
169
69
714
0.95
0.10
4.0
3.6
0.0
0.0
estimate
—
10
122
11
124
0.88
0.09
1.9
2.3
—
—
—
0
0
14
126
1.12
0.09
7.8
5.6
11.7
9.9
mmol/l
0.44
14
117
42
438
0.95
0.08
4.4
4.4
26.1
22.4
%
0.59
18
218
6
71
0.84
0.08
1.8
4.2
23.1
24.7
mmol/l
—
6
66
39
403
0.96
0.05
2.8
3.1
0.2
0.6
e6/l
0.93
31
295
129
1303
0.97
0.04
17.0
14.1
38.3
39.9
%
0.93
82
902
20
190
1.06
0.04
2.0
1.5
—
—
—
0
0
10
108
0.92
0.03
1.7
2.2
—
—
—
0
0
14
133
1.06
0.01
3.2
3.2
—
—
—
0
0
41
406
1.01
0.00
4.7
3.6
0.0
0.0
estimate
—
9
122
138
1377
1.01
0.00
15.0
12.7
76.5
78.1
ml/min/173m2
0.34
112
1126
11
112
0.98
0.00
1.6
1.8
—
—
—
0
0
10
95
1.06
0.00
5.9
5.4
24.6
24.2
mmol/l
—
10
89
17
168
1.01
0.00
3.4
4.5
4.2
68.2
ug/l
0.97
12
154
0
8
0.00
0.00
0.0
1.9
—
904.0
—
0
8
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
100.0
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
98.0
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
13.3
—
0
6
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_ANKYLOSISJOINT and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ANKYLOSISJOINT | 1.198 [0.89, 1.62] | 0.241 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 285 males with M13_ANKYLOSISJOINT died.
Mortality risk
Mortality risk for people of age
years, who have M13_ANKYLOSISJOINT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.302% |
| 5 | No data | 1.378% |
| 10 | No data | 3.297% |
| 15 | No data | 5.964% |
| 20 | No data | 10.437% |
Relationships between endpoints
↥Index endpoint: M13_ANKYLOSISJOINT – Ankylosis of joint
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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