Ankylosis of joint

M13_ANKYLOSISJOINT

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M24.6
  • Hospital discharge: ICD-9 7185
  • Hospital discharge: ICD-8 727
  • Cause of death: ICD-10 M24.6
  • Cause of death: ICD-9 7185
  • Cause of death: ICD-8 727

2 out of 7 registries used, show all original rules.

210

4. Check minimum number of events

None

210

5. Include endpoints

None

210

6. Filter based on genotype QC (FinnGen only)

201

Control definitions (FinnGen only)

Control exclude
M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M24
Name in latin
Ancylosis articulationis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2284 1149 1101
Only index persons 1575 851 724
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 50.86 50.73 50.88
Only index persons 45.49 46.78 43.99

-FinnGen-

Key figures

All Female Male
Number of individuals 201 103 98
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 47.15 46.40 47.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
210
Matched controls
2100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M24.6
ICD-10 Finland
Ankylosis of joint
+∞
111.7
97
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
24.4
67.9
52
28
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
15.4
36.6
34
26
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
35.4
33
*
72710
ICD-8 Finland
Ankylosis of joint, Of shoulder
+∞
27.7
26
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
27.7
22.9
31
13
M16.1
ICD-10 Finland
Other primary coxarthrosis
24.0
22.0
31
15
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
9.8
21.1
26
30
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
53.9
20.6
24
5
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
51.4
19.6
23
5
72700
ICD-8 Finland
Ankylosis of joint, Of spine
+∞
15.8
15
*
M25.5
ICD-10 Finland
Pain in joint
3.8
15.4
58
191
Z01.8
ICD-10 Finland
Other specified special examinations
3.6
15.3
65
232
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
86.3
14.8
16
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
14.8
14
*
L15
ICPC
Knee symptom/complaint
3.9
14.6
51
159
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
7.1
14.4
23
36
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
46.0
14.3
17
*
M01AH01
ATC
celecoxib; oral
3.8
12.6
44
136
NGT60
NOMESCO Finland
Forcible manipulation of knee joint
137.9
12.6
13
*
NF1AA
NOMESCO Finland
Hip X-ray examination
5.5
12.5
26
53
B01AB05
ATC
enoxaparin; parenteral
3.0
11.7
71
309
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
11.6
11
*
WX320
NOMESCO Finland
Spinalanesthesy
3.3
11.3
51
186
N03AX12
ATC
[U] gabapentin; oral
3.6
10.9
41
133
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.7
10.8
89
451
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.5
10.6
42
141
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
10.5
10
*
M01AX05
ATC
glucosamine; oral
3.3
9.9
43
152
72799
ICD-8 Finland
Ankylosis of joint, Of unspecified site
+∞
9.4
9
*
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
9.4
9
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
9.7
9.2
18
20
M09AX01
ATC
hyaluronic acid; parenteral
10.2
9.0
17
18
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
8.9
81
424
NDE60
NOMESCO Finland
Incision and release of adhesions in joint of finger or metacarpal
52.2
8.8
10
*
1220
FHL
Arthroscopy
17.2
8.7
13
8
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
28.9
8.6
11
*
M48.0
ICD-10 Finland
Spinal stenosis
3.3
8.4
34
115
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
8.4
8
*
72760
ICD-8 Finland
Ankylosis of joint, Of knee
+∞
8.4
8
*
72770
ICD-8 Finland
Ankylosis of joint, Of ankle
+∞
8.4
8
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
34.8
8.2
10
*
R51.80
ICD-10 Finland
Headache
3.0
8.0
40
153
M01AH02
ATC
rofecoxib; oral
3.3
8.0
32
107
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
11.4
7.9
14
13
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
7.9
7.8
17
23
M20.1
ICD-10 Finland
Hallux valgus (acquired)
15.8
7.8
12
8
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
46.7
7.8
9
*
S18
ICPC
Laceration/cut
2.3
7.8
93
542
N02AX02
ATC
tramadol; systemic, rectal
2.3
7.7
89
511
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.4
7.4
19
46
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
11.5
7.4
13
12
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
+∞
7.3
7
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
7.3
21
56
9253
FHL
Manipulation under anesthesia or regression and plastering
31.2
7.2
9
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
20.9
7.2
10
5
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
20.9
7.2
10
5
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
12.6
7.2
12
10
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
4.1
7.0
20
53
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
7.1
7.0
16
24
L90
ICPC
Osteoarthrosis of knee
8.7
6.9
14
17
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
6.8
76
426
M01AH05
ATC
etoricoxib; oral
2.1
6.8
107
687
M79.6
ICD-10 Finland
Pain in limb
2.2
6.7
76
427
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.1
6.7
19
50
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
71.9
6.5
7
*
TQW40
NOMESCO Finland
Remowal of suture of skin
4.2
6.3
17
43
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
+∞
6.3
6
*
9271
FHL
Hallux surgery
+∞
6.3
6
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
6.3
60
314
L12
ICPC
Hand/finger symptom/complaint
2.8
6.2
34
136
L13
ICPC
Hip symptom/complaint
2.7
6.2
36
149
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
3.8
6.2
19
53
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
13.0
6.1
10
8

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
134
2.83
6.42
1.2
1.1
1.24
1.29
u/ml
—
7
58
35
164
2.36
4.64
1.3
1.2
11.83
16.49
iu/ml
0.60
11
52
103
748
1.74
3.79
6.2
6.0
1.22
1.22
mmol/l
0.43
90
636
130
1018
1.73
3.56
4.1
3.3
13.74
12.03
mm/h
0.60
120
918
63
419
1.72
3.06
2.5
2.1
283.93
228.10
u/l
0.19
58
395
48
301
1.77
2.84
2.5
2.6
363.05
15718.42
umol/l
3.11
40
253
79
573
1.61
2.70
2.3
1.9
84.09
93.57
pmol/l
1.05
38
296
86
642
1.58
2.58
4.6
4.2
35.37
35.30
g/l
0.04
80
598
31
177
1.88
2.47
1.3
1.2
—
—
—
0
0
27
150
1.92
2.34
7.0
4.3
—
—
—
0
0
45
295
1.67
2.26
1.3
1.2
11.14
1.05
u/ml
0.67
11
81
15
67
2.33
2.23
2.7
2.2
—
—
—
0
0
28
166
1.79
2.00
2.4
2.2
18.22
24.12
%
1.98
23
139
18
92
2.05
1.97
1.1
2.4
—
—
—
0
0
8
27
3.04
1.95
1.4
1.2
6.65
6.39
u/l
—
8
21
27
160
1.79
1.93
2.3
1.6
—
—
—
0
0
49
343
1.56
1.88
2.1
1.8
2.54
3.39
mg/l
1.71
41
290
74
567
1.47
1.86
2.8
2.4
149.83
116.62
ug/l
0.65
67
515
15
73
2.14
1.85
1.1
1.5
—
69.57
—
0
7
41
278
1.59
1.80
1.5
1.5
0.72
1.20
mg/l
1.70
36
210
39
266
1.57
1.67
1.2
1.4
2.99
2.50
g/l
0.39
20
167
23
137
1.76
1.63
2.1
1.6
—
—
—
0
0
37
523
0.64
1.63
3.2
3.0
—
—
—
0
0
125
1073
1.41
1.62
4.9
3.6
15.34
14.92
pmol/l
1.00
113
959
12
57
2.17
1.58
1.0
1.1
—
—
—
0
0
86
695
1.40
1.58
4.2
5.1
0.19
0.19
e9/l
0.05
74
593
7
27
2.65
1.53
1.7
2.0
—
—
—
0
0
14
73
1.98
1.47
1.3
1.3
—
—
—
0
0
57
435
1.43
1.43
4.1
3.7
—
—
—
0
0
25
159
1.65
1.42
1.2
2.4
85.36
145.70
ug/g
0.97
16
124
78
629
1.38
1.42
4.9
5.4
8.22
8.89
%
1.00
71
580
54
411
1.42
1.37
3.5
4.0
—
—
—
0
0
77
625
1.37
1.34
4.6
5.1
2.89
2.80
%
0.12
69
575
22
138
1.66
1.32
3.2
3.4
—
—
—
0
0
79
645
1.36
1.32
4.6
5.3
26.79
26.86
%
0.02
72
596
81
664
1.36
1.32
4.3
5.0
0.59
0.60
e9/l
0.12
69
562
83
683
1.36
1.32
4.3
5.0
1.82
1.82
e9/l
0.01
72
594
76
618
1.36
1.30
4.9
5.7
—
—
—
0
0
81
666
1.35
1.29
4.3
5.0
0.04
0.04
e9/l
0.36
69
565
8
35
2.34
1.28
1.0
1.1
—
—
—
0
0
72
584
1.35
1.24
4.9
3.8
34.91
51.65
ng/l
0.57
59
438
29
406
0.67
1.20
3.2
3.3
—
—
—
0
0
150
1361
1.36
1.19
5.9
5.7
39.91
40.50
mmol/mol
0.34
142
1239
77
635
1.34
1.19
4.3
5.0
58.69
57.68
%
0.29
69
587
51
639
0.73
1.12
7.3
8.2
0.00
0.00
e9/l
1.14
42
507
100
868
1.29
1.04
3.9
4.4
6.57
6.86
mmol/l
0.63
93
820
9
47
1.96
1.03
1.4
1.7
—
—
—
0
0
73
609
1.30
1.02
4.5
5.1
0.61
0.70
%
0.72
67
555
93
803
1.28
1.00
6.7
9.0
4.39
4.18
e9/l
0.38
79
685
84
716
1.29
0.99
14.6
13.7
1.39
1.30
inr
0.20
17
207
10
54
1.89
0.98
2.7
3.4
0.18
0.27
g/l
—
5
23
7
36
1.98
0.98
1.0
1.3
—
—
—
0
0
46
364
1.34
0.92
1.5
1.6
1.44
1.32
mmol/l
0.65
40
284
20
136
1.52
0.90
1.3
1.5
—
—
—
0
0
87
758
1.25
0.84
5.2
6.4
9.85
12.57
umol/l
2.34
82
725
8
47
1.73
0.81
2.0
2.8
—
—
—
0
0
0
26
0.00
0.79
0.0
1.2
—
12.14
—
0
18
23
169
1.41
0.73
1.3
1.5
—
—
—
0
0
55
462
1.26
0.71
3.6
3.9
7.38
7.40
ph
—
6
81
14
93
1.54
0.71
1.3
1.2
—
—
—
0
0
5
26
1.94
0.71
1.2
1.0
—
—
—
0
0
37
296
1.30
0.70
1.9
1.7
1127.38
1175.64
nmol/l
0.13
29
221
8
126
0.62
0.66
1.3
1.4
—
—
—
0
0
42
345
1.27
0.66
1.7
1.5
27.48
20.22
nmol/l
0.68
36
277
5
29
1.74
0.64
1.2
1.6
—
—
—
0
0
10
63
1.62
0.63
1.5
1.7
—
—
—
0
0
15
105
1.46
0.62
1.5
2.5
10.98
9.98
g/l
0.68
15
93
5
30
1.68
0.62
1.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
2.4
—
—
—
0
0
113
1039
1.19
0.58
4.2
3.7
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
143
1344
1.20
0.57
5.9
4.3
1.88
2.84
mu/l
0.53
132
1202
55
474
1.22
0.57
2.9
3.3
—
—
—
0
0
155
1471
1.21
0.54
17.3
13.4
24.05
26.72
mg/l
0.46
124
1119
49
420
1.22
0.54
2.9
3.1
1341.10
352.63
mg/l
0.34
36
280
6
40
1.51
0.52
1.5
1.3
6.95
33.38
iu/l
—
6
32
162
1546
1.21
0.52
19.4
15.7
139.90
139.65
mmol/l
0.64
157
1490
162
1547
1.21
0.51
19.6
15.8
4.00
3.99
mmol/l
0.26
157
1489
7
45
1.57
0.49
1.1
1.1
—
—
—
0
0
7
47
1.51
0.48
1.0
4.1
53.20
49.53
mg/l
—
7
42
34
401
0.82
0.46
1.3
1.3
—
—
—
0
0
13
95
1.39
0.45
2.8
3.0
—
—
—
0
0
49
429
1.19
0.43
2.4
2.2
—
—
—
0
0
49
429
1.19
0.43
3.0
3.0
7.31
7.43
mmol/l
0.08
44
361
38
325
1.21
0.43
4.2
3.5
—
—
—
0
0
5
32
1.58
0.42
1.2
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.4
—
32.13
—
0
15
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.2
1.3
—
—
—
0
0
5
34
1.48
0.40
1.2
1.3
—
—
—
0
0
5
34
1.48
0.40
1.2
1.3
—
—
—
0
0
29
243
1.22
0.40
2.2
2.7
1.41
1.70
e6/l
0.11
17
125
19
151
1.28
0.40
1.2
1.4
—
—
—
0
0
33
281
1.21
0.39
3.5
3.5
125.07
203.28
ng/l
0.30
28
224
5
35
1.44
0.39
1.2
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
274.92
—
0
13
27
320
0.82
0.38
3.6
2.8
0.96
0.97
ug/l
0.01
18
207
106
994
1.13
0.37
4.2
3.8
—
—
—
0
0
9
123
0.72
0.36
3.9
3.4
—
—
—
0
0
6
86
0.69
0.33
1.8
2.8
1.50
1.33
%
—
6
86
163
1579
1.14
0.31
18.3
15.9
83.93
79.66
umol/l
0.50
163
1579
160
1551
1.13
0.29
15.7
12.4
—
—
—
0
0
67
722
0.89
0.28
4.6
5.0
0.00
0.00
estimate
—
8
126
8
62
1.30
0.28
6.3
4.3
—
—
—
0
0
15
180
0.82
0.25
1.2
1.3
—
—
—
0
0
6
84
0.71
0.24
1.8
2.7
0.75
0.68
%
—
6
84
148
1436
1.10
0.23
4.6
4.2
1.46
1.47
mmol/l
0.19
138
1298
48
443
1.11
0.21
3.6
3.7
2.89
11.33
mg/mmol
2.40
34
292
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
1.51
—
0
11
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
70.60
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
0.98
—
0
14
0
14
0.00
0.20
0.0
1.9
—
5.16
—
0
9
15
127
1.20
0.20
7.4
5.6
11.14
9.81
mmol/l
0.30
15
118
69
730
0.92
0.20
3.9
3.6
0.00
0.00
estimate
—
10
123
10
81
1.25
0.19
2.1
4.9
—
—
—
0
0
6
53
1.14
0.19
1.0
1.2
—
—
—
0
0
11
132
0.82
0.19
1.7
2.9
4.20
4.39
kpa
0.21
11
127
152
1484
1.09
0.18
5.1
4.8
2.58
2.71
mmol/l
1.03
143
1341
149
1454
1.09
0.18
4.6
4.3
4.48
4.60
mmol/l
0.81
143
1329
15
130
1.17
0.16
1.3
1.5
—
—
—
0
0
148
1447
1.08
0.16
4.8
4.4
5.91
6.01
mmol/l
0.41
134
1310
69
723
0.93
0.15
4.0
3.6
0.00
0.00
estimate
—
10
133
9
79
1.15
0.15
7.7
2.7
—
—
—
0
0
8
98
0.81
0.14
1.5
1.4
—
—
—
0
0
13
113
1.16
0.13
4.5
3.3
—
—
—
0
0
15
168
0.88
0.12
1.1
1.3
—
—
—
0
0
168
1656
1.07
0.12
23.9
19.3
39.49
40.01
%
0.48
152
1547
14
124
1.14
0.11
1.4
1.4
—
—
—
0
0
19
208
0.90
0.11
1.7
1.8
—
—
—
0
0
53
507
1.06
0.10
3.1
3.7
94.89
92.69
e6/l
0.02
38
358
168
1659
1.06
0.10
23.9
19.3
4.41
4.48
e12/l
0.77
163
1590
168
1659
1.06
0.10
24.0
19.3
249.65
246.09
e9/l
0.27
163
1592
5
45
1.11
0.10
1.0
1.0
—
—
—
0
0
16
176
0.90
0.10
5.1
5.6
11.06
11.68
kpa
0.31
16
168
16
176
0.90
0.10
5.1
5.6
5.11
4.98
kpa
0.21
16
165
168
1660
1.06
0.09
24.1
19.3
6.69
6.71
e9/l
0.04
162
1591
140
1379
1.05
0.08
4.2
3.9
1.31
1.25
mmol/l
0.53
131
1243
7
80
0.87
0.07
1.6
1.9
—
—
—
0
0
10
89
1.13
0.07
1.0
1.2
—
—
—
0
0
10
89
1.13
0.07
1.0
1.4
—
—
—
0
0
36
345
1.05
0.06
4.6
7.4
—
—
—
0
0
41
395
1.05
0.06
2.8
3.1
—
—
—
0
0
34
326
1.05
0.06
5.4
3.8
1.01
1.02
kg/l
—
6
44
11
117
0.94
0.02
1.7
1.4
—
—
—
0
0
46
452
1.02
0.01
2.7
3.2
30.44
62.37
e6/l
0.82
38
340
40
407
0.98
0.01
2.8
3.1
0.20
0.59
e6/l
0.96
32
300
18
174
1.04
0.00
3.3
4.5
4.00
65.78
ug/l
0.97
13
160
12
121
0.99
0.00
1.3
1.6
—
—
—
0
0
13
129
1.01
0.00
4.8
6.9
—
—
—
0
0
57
574
0.99
0.00
2.6
2.1
—
—
—
0
0
41
409
1.00
0.00
4.7
3.5
0.00
0.00
estimate
—
9
123
10
95
1.06
0.00
5.9
5.5
24.57
24.20
mmol/l
—
10
90
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
6.46
—
0
6
0
8
0.00
-0.00
0.0
1.3
—
206.22
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
0.86
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
12.25
—
0
6
7
71
0.99
-0.00
1.7
4.2
23.99
24.55
mmol/l
—
7
71
0
7
0.00
-0.00
0.0
2.6
—
34.11
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
1.8
1.6
—
—
—
0
0
7
77
0.91
-0.00
1.3
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
122.00
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
8.57
—
0
6
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
6.0
—
55.29
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
920.00
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_ANKYLOSISJOINT and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
M13_ANKYLOSISJOINT 1.198 [0.89, 1.62] 0.241
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 285 males with M13_ANKYLOSISJOINT died.

Mortality risk

Mortality risk for people of age

years, who have M13_ANKYLOSISJOINT.

N-year risk Females Males
1 No data 0.302%
5 No data 1.378%
10 No data 3.297%
15 No data 5.964%
20 No data 10.437%

Relationships between endpoints

Index endpoint: M13_ANKYLOSISJOINT – Ankylosis of joint

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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