microscopic colitis: Inflammation of the colon that is only apparent by microscopic examination.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
209 |
4. Check minimum number of eventsNone |
209 |
5. Include endpointsNone |
209 |
6. Filter based on genotype QC (FinnGen only) |
203 |
Control definitions (FinnGen only)
- Control exclude
- M13_NECROVASC
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M31
Similar endpoints
↥List of similar endpoints to
Microscopic polyangiitis
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies (FG)
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 813 | 470 | 342 |
| Only index persons | 808 | 467 | 341 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 68.31 | 67.54 | 69.40 |
| Only index persons | 68.35 | 67.57 | 69.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 203 | 117 | 86 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 67.00 | 65.23 | 69.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 209
- Matched controls
- 2090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L04AX01
ATC
azathioprine; systemic
90.4
206.4
117
29
M31.7
ICD-10 Finland
Microscopic polyangiitis
+∞
199.2
158
*
N08.5*M31.7
ICD-10 Finland
Glomerular disease states in microscopic polyangiitis
+∞
152.4
127
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
55.6
97.1
57
14
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
255.9
92.8
89
6
L04AA06
ATC
mycophenolic acid; systemic
55.7
92.2
54
13
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
15.3
89.8
111
144
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
42.5
85.9
54
17
N17.9
ICD-10 Finland
Acute renal failure, unspecified
21.6
67.5
55
34
A11CC03
ATC
alfacalcidol; systemic
36.2
63.0
41
14
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
15.8
62.3
61
53
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
13.2
56.9
63
66
TK800
NOMESCO Finland
Hemodialysis
25.8
54.6
40
19
B03XA02
ATC
darbepoetin alfa; parenteral
26.4
53.8
39
18
N18.8
ICD-10 Finland
Other chronic renal failure
27.1
53.0
38
17
M31.3
ICD-10 Finland
Wegener granulomatosis
+∞
44.4
41
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
11.1
43.8
53
62
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.4
41.3
58
82
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
+∞
39.9
37
*
H02AB06
ATC
prednisolone; systemic
9.3
39.7
176
762
N08.5
ICD-10 Finland
Glomerular disorders in systemic connective tissue disorders
+∞
38.8
36
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
9.8
37.9
50
65
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.7
37.5
152
596
N08.5*M31.3
ICD-10 Finland
Glomerular disorders in Wegener's granulomatosis
+∞
34.3
32
*
TGC00
NOMESCO Finland
Bronchial lavation
12.9
33.8
35
32
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.3
32.9
71
157
H02AB04
ATC
methylprednisolone; systemic
5.7
30.4
76
191
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
10.4
29.8
36
41
M05BA04
ATC
alendronic acid; oral
6.7
29.6
56
108
Z49.1
ICD-10 Finland
Extracorporeal dialysis
57.6
29.4
34
7
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
57.6
29.4
34
7
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.9
29.0
109
381
C03CA01
ATC
furosemide; systemic
4.5
26.1
120
480
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.5
26.1
64
156
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.3
25.8
51
102
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
+∞
25.5
24
*
GD1AD
NOMESCO Finland
Thorax CT examination
7.5
25.0
40
64
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.0
24.5
159
808
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
7.1
24.5
41
69
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
7.3
24.3
40
66
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
9.7
23.3
29
34
ZX108
NOMESCO Finland
Inhalation
47.1
21.0
25
6
ZX120
NOMESCO Finland
Intravenous
5.2
20.9
51
122
N19
ICD-10 Finland
Unspecified kidney failure
8.5
20.9
29
39
N18.0
ICD-10 Finland
End-stage renal disease
53.9
20.6
24
5
N085, M318,
ICD-10 Finland
+∞
19.0
18
*
Z94.0
ICD-10 Finland
Kidney transplant status
73.3
18.1
20
*
J01MA14
ATC
moxifloxacin; systemic
5.0
18.0
44
105
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.6
17.8
24
31
A12AA04
ATC
calcium carbonate; oral
25.6
16.8
23
10
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
28.9
15.9
21
8
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
6.2
15.7
29
53
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
172.4
15.7
16
*
R50.9
ICD-10 Finland
Fever, unspecified
3.8
15.4
58
191
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
27.4
15.0
20
8
Z49.0
ICD-10 Finland
Preparatory care for dialysis
29.6
14.6
19
7
N17.8
ICD-10 Finland
Other acute renal failure
24.4
14.5
20
9
A02BC02
ATC
pantoprazole; systemic
4.3
14.4
178
1190
D64.9
ICD-10 Finland
Anaemia, unspecified
4.1
14.3
46
135
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.9
14.2
49
151
127
Kela drug reimbursment
Transplant complication
22.0
14.1
20
10
A10AC01
ATC
insulin (human); parenteral
4.6
14.0
37
93
205
Kela drug reimbursment
Chronic hypertension
3.1
13.7
86
386
WW400
NOMESCO Finland
Plasmaferesis
+∞
13.7
13
*
N08.5*M31.0
ICD-10 Finland
Glomerular disorders in Goodpasture's syndrome
+∞
13.7
13
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
13.7
13
*
JN4AD
NOMESCO Finland
Body CT examination
4.0
13.5
44
130
KA1AE
NOMESCO Finland
Kidney ultrasound examination
13.4
13.5
23
19
L04AD02
ATC
tacrolimus; systemic
43.1
13.4
16
*
C08CA01
ATC
amlodipine; oral
2.9
12.9
120
662
N08.5*M30.0
ICD-10 Finland
Glomerular disorders in polyarteritis nodosa
+∞
12.6
12
*
J01MA12
ATC
levofloxacin; systemic
3.1
12.3
66
268
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
28.7
12.2
16
6
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
126.7
11.5
12
*
R04.2
ICD-10 Finland
Haemoptysis
6.0
11.4
21
38
L01AA01
ATC
cyclophosphamide; systemic
45.9
11.0
13
*
R31
ICD-10 Finland
Unspecified haematuria
3.6
10.8
40
128
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
10.8
71
321
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
5.3
10.5
22
45
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
115.6
10.5
11
*
137
Kela drug reimbursment
Uraemia requiring dialysis
34.5
10.5
13
*
Z49.2
ICD-10 Finland
Other dialysis
42.2
10.1
12
*
3025
Kela drug reimbursment
Calcium carbonate
42.2
10.1
12
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
10.0
36
113
N18.3
ICD-10 Finland
Chronic kidney disease, stage 3
11.5
10.0
18
17
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
27.5
9.9
13
5
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
9.8
59
252
B05DB
ATC
Hypertonic solutions
57.7
9.7
11
*
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
11.5
9.5
17
16
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
9.4
9
*
M31.0
ICD-10 Finland
Hypersensitivity angiitis
+∞
9.4
9
*
M30.0
ICD-10 Finland
Polyarteritis nodosa
+∞
9.4
9
*
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
+∞
9.4
9
*
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.0
9.4
28
77
V03AE02
ATC
sevelamer; oral
38.5
9.1
11
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.3
9.0
38
132
PAW37
NOMESCO Finland
Biopsy of temporal artery
52.2
8.8
10
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
28.9
8.6
11
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
93.7
8.5
9
*
J99.1*M31.3
ICD-10 Finland
Respiratory disorders in Wegener's granulomatosis
+∞
8.4
8
*
1AA01, ,
NOMESCO Finland
+∞
8.4
8
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.5
8.4
31
99
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.5
8.2
30
95
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
34.8
8.2
10
*
B05DA
ATC
Isotonic solutions
34.8
8.2
10
*
TK820
NOMESCO Finland
Peritoneal dialysis
46.8
7.8
9
*
C02AC05
ATC
moxonidine; oral
4.4
7.7
20
49
JN3AD
NOMESCO Finland
Abdominal CT examination
3.0
7.7
37
139
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.9
7.6
41
164
J47
ICD-10 Finland
Bronchiectasis
8.2
7.5
16
21
H03AA01
ATC
levothyroxine sodium; systemic
2.4
7.5
63
314
B01AF02
ATC
apixaban; oral
2.8
7.4
41
166
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
7.3
101
620
C08CA02
ATC
felodipine; oral
3.3
7.3
30
102
B03XA01
ATC
erythropoietin; parenteral
16.5
7.3
11
7
TK810
NOMESCO Finland
Hemofiltration
20.9
7.2
10
5
C10AA05
ATC
atorvastatin; oral
2.2
7.0
111
717
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.8
6.9
22
63
M35.3
ICD-10 Finland
Polymyalgia rheumatica
4.2
6.9
19
49
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
41.4
6.8
8
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
5.9
6.8
18
33
R05
ICD-10 Finland
Cough
2.4
6.8
57
283
3AC01, ,
NOMESCO Finland
23.4
6.7
9
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
6.7
72
397
J01CA04
ATC
amoxicillin; systemic
2.8
6.6
180
1439
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.8
6.5
20
56
J05AB11
ATC
valaciclovir; oral
2.5
6.5
45
204
KBV00
NOMESCO Finland
Insertion of stent into ureter
72.0
6.5
7
*
D638, N188,
ICD-10 Finland
72.0
6.5
7
*
R4190
NOMESCO Finland
Nutritional therapy
4.2
6.3
17
43
N05.9
ICD-10 Finland
Unspecified nephritic syndrome, unspecified
+∞
6.3
6
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
27.6
6.3
8
*
1XC02, ,
NOMESCO Finland
27.6
6.3
8
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
27.6
6.3
8
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.0
6.3
29
106
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
4.2
6.0
16
40
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
96
31
56.43
155.87
3.8
1.1
246.67
—
titre
—
12
0
62
13
67.39
109.73
2.0
1.1
—
—
u/ml
—
0
0
120
254
9.75
62.66
6.1
2.2
23.40
21.81
%
0.72
112
214
48
33
18.58
55.46
6.6
7.2
487.00
156.60
iu/ml
—
13
5
53
52
13.32
49.65
1.8
1.5
5.56
0.09
iu/ml
—
6
10
156
532
8.62
48.36
13.7
3.3
157.67
170.08
mg/l
0.04
147
350
176
681
11.03
47.82
19.5
3.2
—
—
—
0
0
89
183
7.73
45.81
13.2
4.5
1.31
1.97
mmol/l
0.88
82
151
89
185
7.64
45.28
13.2
4.4
5.86
5.82
kpa
0.15
89
180
155
570
7.65
42.79
17.0
3.9
26.85
8.62
mg/mmol
3.00
146
356
127
402
6.50
40.89
11.1
2.6
2.05
4.50
e6/l
5.39
121
355
170
738
7.99
37.37
4.3
2.3
86.02
77.54
nmol/l
3.56
164
641
149
578
6.50
37.11
16.2
3.3
42.01
158.68
e6/l
0.52
142
444
44
52
10.45
35.74
1.8
1.5
—
—
—
0
0
46
58
9.89
35.58
1.3
4.5
62.81
34.65
mg/l
3.28
37
45
46
58
9.89
35.58
1.3
4.5
80.02
172.42
mg/l
0.37
37
44
74
159
6.66
35.55
1.7
2.9
62.42
66.83
g/l
3.31
63
142
188
931
11.14
34.85
27.3
7.2
1.21
1.22
mmol/l
0.36
169
783
35
37
11.16
30.61
1.4
1.6
—
—
—
0
0
134
542
5.10
29.74
16.1
3.2
0.18
0.55
e6/l
2.18
127
405
124
474
4.97
29.54
5.3
3.0
382.97
7314.41
umol/l
2.17
118
394
47
76
7.69
29.31
1.1
2.3
34.80
37.93
u/l
0.40
42
69
37
45
9.78
29.19
1.9
1.7
—
—
—
0
0
38
48
9.45
29.12
1.3
1.9
—
—
—
0
0
46
75
7.58
28.43
2.5
1.8
0.96
5.07
ug/l
0.55
40
65
31
31
11.57
28.07
1.4
1.6
—
—
—
0
0
36
45
9.46
27.76
2.0
1.7
—
—
—
0
0
191
1074
10.04
27.47
21.1
9.4
4.93
4.07
e9/l
5.56
181
939
57
122
6.05
26.90
11.9
4.0
0.74
1.79
mmol/l
1.46
45
94
31
33
10.86
26.86
1.9
1.8
—
—
—
0
0
95
315
4.70
26.68
2.8
1.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
39
61
7.63
24.88
3.9
3.2
0.39
0.35
u/ml
0.25
24
35
93
329
4.29
23.46
11.5
2.9
0.47
1.09
e6/l
2.58
75
185
108
426
4.18
23.38
2.5
2.1
3.01
3.18
mg/l
0.31
93
369
28
32
9.95
22.96
1.5
1.6
—
—
—
0
0
27
30
10.19
22.58
1.7
1.3
—
—
—
0
0
26
29
10.10
21.66
2.0
1.4
—
—
—
0
0
70
222
4.24
20.09
2.3
1.9
—
—
—
0
0
159
881
4.36
19.94
15.3
4.7
0.00
0.00
estimate
-0.00
37
188
157
881
4.14
18.88
11.2
3.6
0.03
0.00
estimate
0.36
39
201
158
891
4.17
18.85
11.1
3.6
0.00
0.00
estimate
-0.00
37
178
29
44
7.49
18.83
1.5
1.3
4.11
2.43
u/ml
—
9
10
81
302
3.75
18.23
13.0
3.1
0.99
2.34
e6/l
1.61
63
161
186
1200
6.00
17.95
10.8
4.5
187.83
191.41
e6/l
—
6
22
26
39
7.47
17.00
1.5
1.3
—
—
—
0
0
66
225
3.83
16.79
2.4
1.9
—
—
—
0
0
15
0
+∞
15.82
1.2
0.0
—
—
—
0
0
25
42
6.63
14.69
2.5
1.1
—
—
—
0
0
114
582
3.11
14.66
2.2
2.1
153.85
171.18
u/l
0.16
108
546
25
21
13.35
14.53
1.9
1.4
—
—
—
0
0
95
443
3.10
14.25
2.0
1.6
20.06
21.22
nmol/l
0.29
87
360
93
431
3.09
14.07
3.6
2.5
—
—
—
0
0
35
85
4.74
13.85
1.4
1.9
3.87
3.69
g/l
0.27
29
76
35
85
4.74
13.85
1.4
1.9
—
—
—
0
0
35
85
4.74
13.85
1.4
1.9
8.28
7.62
g/l
1.07
29
76
31
68
5.18
13.81
3.4
2.9
—
—
—
0
0
26
27
10.83
13.68
1.5
1.7
—
—
—
0
0
22
36
6.71
13.22
1.3
1.6
—
—
—
0
0
22
36
6.71
13.22
1.3
1.6
—
—
—
0
0
50
164
3.69
13.20
5.9
9.0
1.27
1.36
mmol/l
0.22
50
159
25
29
9.64
12.43
1.8
1.4
246.22
295.21
u/ml
0.15
18
14
23
23
11.09
12.35
1.7
1.6
—
—
—
0
0
20
15
14.60
12.22
2.1
3.5
—
—
—
0
0
45
146
3.65
12.01
3.0
2.9
46.42
62.17
ml/min/173m2
2.64
24
64
32
82
4.43
11.79
1.4
1.9
11.07
10.78
g/l
0.15
25
72
31
78
4.49
11.68
1.5
1.9
3.82
3.18
g/l
1.60
25
69
23
26
9.80
11.61
1.1
1.1
—
—
—
0
0
141
881
2.85
11.43
12.0
13.1
1.07
1.26
inr
3.80
38
264
77
357
2.83
11.19
2.1
1.7
1128.23
1200.88
nmol/l
0.28
66
262
60
243
3.06
11.14
6.5
7.0
103.98
103.82
mmol/l
0.08
60
243
38
117
3.75
10.90
2.7
1.7
—
—
—
0
0
133
827
2.67
10.54
3.9
2.8
—
—
—
0
0
23
31
8.20
10.52
1.8
1.8
—
—
—
0
0
23
31
8.20
10.52
1.8
1.8
—
—
—
0
0
17
13
14.11
10.36
1.6
1.5
—
—
—
0
0
28
72
4.34
10.23
3.1
1.9
—
—
—
0
0
32
92
3.93
10.08
6.2
2.6
0.67
0.67
%
0.00
32
92
23
51
4.94
10.05
6.9
2.7
23.41
25.18
mmol/l
1.18
23
51
32
93
3.88
9.93
6.2
2.6
1.07
1.05
%
0.07
32
93
111
646
2.53
9.91
5.3
3.2
2.32
2.36
mmol/l
1.74
103
563
18
18
10.82
9.73
1.1
1.1
—
—
—
0
0
22
32
7.55
9.61
6.5
4.0
64.41
59.09
%
0.84
22
32
63
283
2.76
9.52
1.3
1.3
102.92
39.90
iu/ml
0.96
19
93
26
67
4.29
9.46
3.0
1.7
—
—
—
0
0
154
1062
2.71
9.37
10.4
5.7
6.96
6.70
mmol/l
0.48
149
988
119
728
2.47
9.36
2.6
2.0
101.52
95.27
pmol/l
0.60
71
356
77
389
2.55
9.14
2.3
1.9
2.84
1.36
mg/l
1.22
68
311
13
7
19.69
9.05
2.7
1.4
—
—
—
0
0
59
264
2.72
8.93
1.3
1.3
23.38
13.37
u/ml
0.30
24
95
21
32
7.17
8.92
6.4
3.3
4.59
4.79
e9/l
0.11
21
32
30
91
3.68
8.73
9.4
4.0
55.86
46.77
%
1.29
30
91
16
16
10.72
8.69
2.9
1.4
471.88
516.91
e6/l
0.11
16
11
26
72
3.98
8.59
1.5
1.9
30.59
37.48
g/l
3.10
20
63
15
14
11.44
8.44
2.1
1.5
—
—
—
0
0
50
214
2.76
8.18
6.1
10.9
4.89
5.21
kpa
2.06
50
206
26
75
3.82
8.12
1.5
2.3
0.15
0.53
g/l
0.78
21
63
21
52
4.38
8.01
1.4
1.3
—
—
—
0
0
13
11
12.51
7.69
1.8
1.4
—
—
—
0
0
13
11
12.51
7.69
1.8
1.4
—
—
—
0
0
14
14
10.62
7.66
1.9
1.7
—
—
—
0
0
17
24
7.61
7.65
1.8
1.5
—
—
—
0
0
17
24
7.61
7.65
1.8
1.5
—
—
—
0
0
36
134
3.04
7.56
1.8
1.5
—
—
—
0
0
30
103
3.23
7.20
1.3
1.3
—
26.91
—
0
8
48
214
2.61
7.19
6.4
11.0
0.32
1.47
mmol/l
1.39
41
180
29
100
3.21
6.91
1.4
1.4
—
—
—
0
0
17
40
4.54
6.89
2.2
2.5
535.16
63.95
ug/min
1.32
12
25
18
45
4.28
6.77
3.3
2.2
118.91
128.39
g/l
0.69
11
31
196
1645
4.08
6.49
40.5
14.6
53.40
77.87
ml/min/173m2
23.47
180
1356
6
0
+∞
6.28
1.5
0.0
—
—
—
0
0
38
163
2.63
6.10
11.3
4.0
1.22
1.23
mmol/l
0.63
38
144
82
492
2.10
6.05
12.1
3.8
0.00
0.00
estimate
-0.00
36
181
92
579
2.05
5.95
3.7
3.2
2318.37
1085.82
ng/l
2.25
82
481
42
197
2.42
5.58
4.4
3.4
—
—
—
0
0
8
5
16.55
5.45
1.0
1.0
1747.00
1489.80
miu/ml
—
8
5
5
0
+∞
5.23
1.8
0.0
—
—
—
0
0
12
19
6.63
5.16
2.2
2.1
—
—
—
0
0
11
16
7.19
5.02
1.2
1.4
—
—
—
0
0
13
24
5.70
5.00
1.4
1.3
44.67
1.33
u/ml
—
6
6
143
1091
1.98
4.99
3.8
3.2
51.46
49.93
u/l
0.07
136
1004
102
700
1.89
4.87
5.9
4.0
45.89
36.66
ng/l
0.58
89
511
9
10
9.34
4.83
1.1
1.4
—
—
—
0
0
12
22
5.72
4.68
2.2
2.0
—
—
—
0
0
15
36
4.41
4.62
3.8
2.6
14.67
16.45
%
—
10
19
9
11
8.49
4.61
3.2
1.5
—
—
—
0
0
14
41
3.59
4.26
1.6
1.3
—
—
—
0
0
11
22
5.22
4.06
1.7
1.4
—
—
—
0
0
11
22
5.22
4.06
1.7
1.4
—
—
—
0
0
11
22
5.22
4.06
1.7
1.4
—
—
—
0
0
11
22
5.22
4.06
1.7
1.4
—
—
—
0
0
15
48
3.29
4.01
1.6
1.5
234.50
269.31
ug/g
—
6
26
12
27
4.65
4.00
1.4
1.3
4.17
5.40
u/ml
—
6
10
61
374
1.89
3.98
1.9
1.8
444.37
449.94
pmol/l
0.06
52
309
11
23
4.99
3.93
1.7
1.3
—
—
—
0
0
11
23
4.99
3.93
1.7
1.3
—
—
—
0
0
10
19
5.47
3.88
2.0
2.1
—
—
—
0
0
9
15
6.22
3.86
6.8
2.5
—
—
—
0
0
128
988
1.76
3.81
3.4
2.7
—
—
—
0
0
6
5
12.30
3.78
1.0
1.0
101.83
104.00
%
—
6
5
188
1648
2.40
3.71
5.9
4.3
1.32
1.26
mmol/l
0.77
180
1480
8
12
6.88
3.71
1.3
2.0
—
—
—
0
0
8
12
6.88
3.71
1.3
2.0
—
—
—
0
0
192
1701
2.58
3.65
6.6
4.7
1.46
1.49
mmol/l
0.33
187
1538
193
1715
2.64
3.63
6.5
4.8
4.37
4.61
mmol/l
2.83
187
1562
95
681
1.72
3.62
13.3
3.6
—
—
—
0
0
11
26
4.41
3.56
1.2
1.2
—
—
—
0
0
159
1324
1.84
3.48
4.5
4.0
15.47
14.83
pmol/l
2.28
152
1173
15
53
2.97
3.43
1.8
1.5
—
—
—
0
0
6
7
8.78
3.28
1.8
2.9
—
—
—
0
0
6
7
8.78
3.28
1.8
2.9
—
—
—
0
0
13
41
3.31
3.12
1.4
1.3
—
—
—
0
0
13
41
3.31
3.12
1.2
1.2
—
—
—
0
0
13
45
3.01
3.08
1.1
1.1
—
—
—
0
0
6
8
7.68
3.07
1.5
1.1
8.50
34.88
u/l
—
6
8
6
8
7.68
3.07
1.5
1.1
56.00
85.00
u/l
—
6
8
5
5
10.20
2.99
1.0
3.2
—
—
—
0
0
194
1756
2.46
2.98
6.8
5.3
2.48
2.70
mmol/l
3.67
189
1589
54
348
1.74
2.92
3.4
3.9
195.26
166.28
ng/l
0.11
46
282
204
1919
3.63
2.84
68.3
22.8
37.90
40.06
%
6.70
198
1802
8
18
4.58
2.82
1.8
2.1
—
—
—
0
0
8
18
4.58
2.82
1.8
2.1
—
—
—
0
0
8
18
4.58
2.82
1.8
2.1
—
—
—
0
0
39
230
1.86
2.82
5.8
4.7
32.29
32.59
%
0.07
34
150
5
6
8.50
2.76
2.0
3.0
—
—
—
0
0
5
6
8.50
2.76
2.0
3.0
—
—
—
0
0
5
6
8.50
2.76
2.0
3.0
—
—
—
0
0
7
14
5.13
2.75
1.1
1.3
—
—
—
0
0
9
24
3.87
2.70
2.0
1.4
—
—
—
0
0
10
30
3.45
2.64
1.2
1.1
—
—
—
0
0
7
15
4.79
2.62
6.7
4.2
—
—
—
0
0
8
20
4.12
2.59
1.0
1.3
—
—
—
0
0
8
20
4.12
2.59
1.0
1.3
—
—
—
0
0
8
20
4.12
2.59
1.0
1.3
—
—
—
0
0
8
20
4.12
2.59
1.0
1.3
—
—
—
0
0
8
20
4.12
2.59
1.0
1.3
—
—
—
0
0
13
50
2.71
2.58
1.2
1.2
—
—
—
0
0
5
7
7.28
2.56
1.4
1.3
203.80
106.29
iu/ml
—
5
7
35
208
1.82
2.47
2.5
3.5
5.30
7.45
umol/l
1.00
30
182
57
389
1.64
2.47
1.5
1.3
0.55
1.65
u/ml
1.09
19
94
5
8
6.37
2.38
1.2
1.1
—
—
—
0
0
5
8
6.37
2.38
1.2
1.1
—
—
—
0
0
9
28
3.31
2.33
6.8
3.1
—
—
—
0
0
14
60
2.43
2.27
1.5
1.5
—
—
—
0
0
5
9
5.66
2.22
1.2
1.2
—
—
—
0
0
5
9
5.66
2.22
1.2
1.2
—
—
—
0
0
5
9
5.66
2.22
1.4
1.0
—
—
—
0
0
6
14
4.38
2.16
1.5
2.2
—
—
—
0
0
179
1615
1.75
2.16
5.8
4.8
1.99
1.96
mu/l
0.12
172
1441
7
20
3.58
2.07
1.1
1.1
—
—
—
0
0
51
357
1.57
1.96
10.5
3.9
1.01
1.02
kg/l
—
7
51
5
11
4.63
1.95
1.4
1.2
—
—
—
0
0
5
12
4.24
1.83
1.0
1.0
—
—
—
0
0
169
1525
1.57
1.77
51.2
18.6
15.54
15.13
%
0.42
169
1506
21
119
1.85
1.74
9.5
10.4
24.19
25.04
mmol/l
0.66
21
114
5
14
3.63
1.62
1.6
1.1
—
—
—
0
0
5
14
3.63
1.62
1.6
1.1
—
—
—
0
0
39
273
1.53
1.50
1.6
1.5
—
—
—
0
0
72
571
1.40
1.46
4.4
5.1
2.71
2.64
ug/l
0.03
60
503
32
219
1.54
1.36
14.6
8.0
—
—
—
0
0
9
42
2.19
1.35
1.9
1.6
—
—
—
0
0
5
22
2.30
1.04
1.6
1.4
—
—
—
0
0
8
42
1.94
0.89
2.0
1.1
3.44
4.20
mmol/l
—
8
37
7
41
1.73
0.70
8.7
1.1
0.87
0.77
nmol/l
—
7
33
11
69
1.63
0.70
1.2
1.2
—
—
—
0
0
54
455
1.25
0.68
3.2
4.4
25.84
21.40
%
1.11
30
227
11
70
1.60
0.66
1.2
1.2
—
—
—
0
0
29
227
1.32
0.64
2.2
4.7
2.90
24.22
ug/l
0.62
22
192
178
1713
1.26
0.54
7.8
4.8
5.85
5.98
mmol/l
0.67
167
1552
6
40
1.51
0.52
1.2
1.6
—
—
—
0
0
8
118
0.67
0.47
1.3
1.7
—
—
—
0
0
6
94
0.63
0.43
1.5
1.0
—
—
—
0
0
5
32
1.58
0.42
11.8
2.7
107.60
106.09
mmol/l
—
5
32
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
—
—
0
0
5
36
1.40
0.38
1.0
1.1
21.46
21.21
u/l
—
5
28
39
346
1.16
0.30
2.5
3.2
0.76
0.79
ug/l
0.15
34
235
5
38
1.32
0.23
2.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
6
48
1.26
0.20
1.2
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
11
93
1.19
0.15
1.2
1.3
—
—
—
0
0
26
246
1.06
0.06
1.5
1.4
—
—
—
0
0
12
112
1.08
0.03
2.3
1.9
—
—
—
0
0
11
104
1.06
0.01
1.6
1.3
191.74
172.87
iu/ml
—
5
42
15
154
0.97
0.00
4.1
3.3
561.73
185.65
ng/l
0.62
15
139
10
103
0.97
0.00
2.4
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
54.88
—
0
8
0
5
0.00
-0.00
0.0
1.8
—
7.74
—
0
5
0
5
0.00
-0.00
0.0
3.6
—
0.07
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
3.80
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_MICROPOLYANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MICROPOLYANG | 2.749 [1.87, 4.04] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.51 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 398 females with M13_MICROPOLYANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MICROPOLYANG | 2.227 [1.42, 3.48] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.08 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 278 males with M13_MICROPOLYANG died.
Mortality risk
Mortality risk for people of age
years, who have M13_MICROPOLYANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.3% | 0.427% |
| 5 | 1.814% | 2.869% |
| 10 | 4.159% | 6.919% |
| 15 | 8.407% | 12.425% |
| 20 | 14.379% | 21.206% |
Relationships between endpoints
↥Index endpoint: M13_MICROPOLYANG – Microscopic polyangiitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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