This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Wet age-related macular degeneration, under 50
WET_AMD_EARLY
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE<50 Registry filters:
2 out of 7 registries used, show all original rules. |
120 |
4. Check minimum number of eventsNone |
120 |
5. Include endpointsNone |
120 |
6. Filter based on genotype QC (FinnGen only) |
120 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF12
- Parent code in ICD-10
- H35
- Name in latin
- Degeneratio maculae senilis exsudativa
Similar endpoints
↥List of similar endpoints to
Wet age-related macular degeneration, under 50
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 120 | 63 | 57 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 42.02 | 41.12 | 43.01 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 102
- Matched controls
- 1018
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
11750.2
137.4
101
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
160.4
54.7
54
7
XCK10
NOMESCO Finland
Photography of fundus of eye
29.7
40.7
58
43
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
36.4
37.6
49
25
XCD20
NOMESCO Finland
Photoangiography of eye
251.2
35.1
34
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
23.1
35.0
54
47
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
36.9
29.8
38
16
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
139.6
29.5
30
*
CKC12
NOMESCO Finland
Photocoagulation of retina
22.5
23.2
34
22
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
138.6
21.5
22
*
H36.01
ICD-10 Finland
Diabetic maculopathy
41.7
18.9
23
7
Z01.0
ICD-10 Finland
Examination of eyes and vision
9.0
18.7
45
82
CKC10
NOMESCO Finland
Local photocoagulation of retina
52.1
18.1
21
5
A10AE05
ATC
insulin detemir; parenteral
13.7
15.4
27
26
A10AA01
ATC
NA
14.6
14.2
24
21
H35.7
ICD-10 Finland
Separation of retinal layers
40.3
14.0
17
5
H3603, E103
ICD-10 Finland
NA
40.3
14.0
17
5
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
11.9
13.5
25
27
H43.1
ICD-10 Finland
Vitreous haemorrhage
26.9
13.4
18
8
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
12.7
13.4
24
24
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
15.2
13.4
22
18
XCH00
NOMESCO Finland
Eye pressure measurement
20.9
13.1
19
11
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
20.9
13.1
19
11
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
80.2
12.9
14
*
ZXA10
NOMESCO Finland
Bilateral
6.8
12.9
36
76
A10AA02
ATC
NA
12.6
12.8
23
23
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
8.6
12.8
29
45
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
9.0
12.4
27
39
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
10.1
11.9
24
30
H35.9
ICD-10 Finland
Retinal disorder, unspecified
134.6
11.7
12
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
134.6
11.7
12
*
103
Kela drug reimbursment
Diabetes, insulin-treated
5.0
11.1
42
126
S01EC01
ATC
acetazolamide; systemic
26.7
10.6
14
6
H3601, E103
ICD-10 Finland
NA
26.7
10.6
14
6
215
Kela drug reimbursment
Diabetes, non-insulin-treated
4.6
9.9
40
126
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
61.0
9.9
11
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
61.0
9.9
11
*
T89
ICPC
Diabetes insulin dependent
8.8
9.8
21
29
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
109.8
9.6
10
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
9.5
9
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
21.0
9.2
13
7
H04AA01
ATC
glucagon; nasal, parenteral
10.5
9.0
17
19
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
30.5
8.7
11
*
H3600, E103
ICD-10 Finland
NA
14.5
8.7
14
11
A10AE04
ATC
insulin glargine; parenteral
6.1
8.6
24
49
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
97.8
8.6
9
*
TCK00
NOMESCO Finland
Photosensitisation of choroid and retina
+∞
8.4
8
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
+∞
8.4
8
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
36.6
8.2
10
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
8.6
8.1
17
23
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
6.1
8.0
22
44
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
8.3
7.9
17
24
S01ED51
ATC
timolol, combinations; ophthalmic
10.1
7.9
15
17
ZXA05
NOMESCO Finland
Left side
4.0
7.7
34
113
CA1ME
NOMESCO Finland
Ultrasound oculometry
86.1
7.5
8
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
17.4
7.4
11
7
XCK00
NOMESCO Finland
Perimetry
9.9
7.3
14
16
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
32.6
7.3
9
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
10.4
7.0
13
14
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
18.3
6.9
10
6
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
43.0
6.9
8
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
13.5
6.8
11
9
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.3
6.7
39
159
ZX198
NOMESCO Finland
Other local administration
74.3
6.5
7
*
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
12.1
6.5
11
10
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
28.6
6.3
8
*
A10AE06
ATC
insulin degludec; parenteral
6.6
6.1
15
26
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
215
3.16
8.35
9.9
4.0
44.81
9.65
mg/mmol
0.92
40
150
12
20
6.56
7.05
3.2
2.0
3.23
3.95
g/l
0.74
12
20
6
0
+∞
6.30
5.7
0.0
512.67
—
umol/l
—
6
0
12
24
5.44
5.88
1.8
1.3
—
—
—
0
0
10
17
6.33
5.72
2.5
2.1
—
—
—
0
0
25
92
3.17
5.52
1.6
1.5
1193.80
1229.11
nmol/l
0.07
20
73
15
41
4.04
5.11
7.1
4.6
20.33
24.86
mmol/l
1.65
15
41
19
62
3.45
5.05
15.3
2.8
5.69
5.77
kpa
0.12
19
62
51
284
2.38
4.99
1.8
1.7
94.12
100.06
pmol/l
0.27
24
155
11
25
4.74
4.67
2.8
1.3
—
—
—
0
0
22
89
2.80
4.08
7.5
1.9
22.75
25.57
%
0.54
17
76
15
51
3.22
3.72
5.1
2.1
5.06
4.45
kpa
0.74
15
51
7
10
7.35
3.41
1.3
1.2
—
—
—
0
0
17
66
2.84
3.38
2.6
2.3
68.00
76.20
ml/min/173m2
—
6
30
20
85
2.62
3.37
1.5
1.9
404.20
360.40
nmol/l
0.61
20
80
41
242
2.05
3.25
1.4
1.3
5.62
0.72
u/ml
0.53
14
66
13
45
3.12
3.13
4.6
3.5
115.38
133.91
g/l
1.30
13
45
18
76
2.61
3.07
15.1
14.6
4.93
5.15
kpa
0.51
18
69
60
417
1.88
2.89
5.9
2.6
90.22
101.06
ug/l
0.35
60
394
8
18
4.68
2.85
1.4
1.5
—
—
—
0
0
11
37
3.17
2.77
17.5
3.5
23.49
24.25
mmol/l
0.39
11
37
32
182
2.03
2.76
2.3
1.7
1.20
0.64
mg/l
0.70
23
141
12
44
2.92
2.63
2.5
2.0
619.43
2220.95
u/l
—
5
17
15
63
2.58
2.58
16.7
17.0
110.07
127.79
g/l
1.66
15
56
8
21
4.00
2.51
4.3
2.3
—
—
—
0
0
8
22
3.82
2.41
1.1
1.1
—
—
—
0
0
12
47
2.73
2.35
2.2
4.0
67.30
68.99
g/l
0.24
12
47
7
19
3.84
2.18
4.1
1.9
160.43
158.89
%
—
7
19
7
19
3.84
2.18
4.0
1.8
—
—
—
0
0
20
104
2.11
2.16
2.3
1.9
—
—
—
0
0
51
363
1.70
2.10
26.2
8.0
1.20
1.21
mmol/l
0.34
46
311
42
287
1.71
1.99
2.7
2.7
23.28
22.91
ng/l
0.01
26
140
9
35
2.70
1.84
5.3
2.7
65.32
51.21
%
—
9
35
103
907
1.96
1.80
5.1
4.3
1.75
1.77
mu/l
0.05
96
864
11
48
2.42
1.76
1.7
1.6
406.73
321.05
mu/l
0.53
11
43
5
13
3.96
1.73
1.4
1.0
108.20
116.85
%
—
5
13
106
948
2.01
1.68
17.9
9.1
84.61
91.31
ml/min/173m2
1.79
91
762
88
747
1.67
1.67
4.3
3.8
14.53
14.58
pmol/l
0.07
82
710
10
43
2.45
1.65
19.8
10.4
0.76
0.68
%
—
10
43
26
164
1.75
1.60
1.8
1.4
27.62
22.05
nmol/l
0.72
26
146
7
26
2.79
1.60
2.0
1.7
—
—
—
0
0
7
26
2.79
1.60
1.3
3.7
—
—
—
0
0
10
44
2.39
1.58
19.0
10.2
1.66
1.80
%
—
10
44
5
15
3.43
1.54
1.2
1.9
—
—
—
0
0
20
118
1.83
1.53
5.1
2.2
0.46
0.80
e6/l
—
9
59
10
45
2.33
1.51
19.7
10.1
94.25
93.87
%
—
10
45
5
16
3.21
1.45
1.4
1.1
—
—
—
0
0
19
113
1.81
1.42
5.3
2.3
1.46
3.35
e6/l
—
8
54
5
19
2.70
1.23
1.0
1.8
—
—
—
0
0
35
256
1.52
1.20
1.7
1.7
1.47
1.49
mmol/l
0.05
29
225
6
26
2.37
1.20
1.0
1.1
—
1.09
—
0
7
5
20
2.56
1.16
1.6
1.6
75.40
49.33
pmol/l
—
5
20
11
59
1.95
1.11
1.7
1.7
—
—
—
0
0
55
446
1.43
1.11
5.5
2.8
0.00
0.00
estimate
—
9
75
74
839
0.69
1.11
3.3
3.6
—
—
—
0
0
5
22
2.33
1.04
3.0
2.8
5.02
4.23
g/l
—
5
16
5
22
2.33
1.04
3.0
2.8
—
—
—
0
0
67
568
1.41
1.03
11.5
10.3
4.57
3.98
e9/l
1.05
62
499
12
69
1.82
1.00
2.1
3.0
—
—
—
0
0
35
267
1.44
0.97
3.3
3.5
2.33
2.34
mmol/l
0.23
30
245
21
145
1.54
0.93
4.7
2.9
22.20
208.47
ng/l
1.23
15
83
6
28
2.20
0.93
1.2
1.5
0.22
0.25
g/l
—
6
28
6
29
2.12
0.90
1.2
1.5
1.13
1.17
g/l
—
6
29
8
43
1.92
0.89
1.7
3.4
14.63
39.59
u/ml
—
8
43
6
30
2.05
0.88
1.0
1.1
—
—
—
0
0
6
31
1.98
0.85
1.0
1.1
—
—
—
0
0
53
443
1.35
0.84
8.7
3.9
0.00
0.00
estimate
—
9
76
8
46
1.79
0.84
1.5
1.2
—
—
—
0
0
27
202
1.43
0.82
8.7
2.5
0.16
0.31
e6/l
0.50
19
142
95
872
1.43
0.81
21.9
13.3
13.60
13.47
%
0.39
95
861
114
1094
1.84
0.77
15.1
8.9
28.37
30.12
u/l
0.55
114
1074
26
196
1.42
0.76
4.0
2.0
—
—
—
0
0
53
450
1.32
0.74
5.7
2.8
0.00
0.00
estimate
—
9
71
5
25
2.04
0.73
1.2
2.0
—
—
—
0
0
5
26
1.96
0.71
1.6
1.8
9.66
1.16
ug/l
—
5
26
12
79
1.58
0.65
1.5
1.7
—
—
—
0
0
36
294
1.32
0.65
9.7
2.6
52.86
54.29
u/l
0.13
36
274
8
50
1.64
0.63
1.5
1.2
—
—
—
0
0
8
50
1.64
0.63
1.6
1.7
—
—
—
0
0
12
80
1.56
0.62
1.5
1.7
—
—
—
0
0
5
30
1.69
0.62
1.0
1.5
—
—
—
0
0
48
411
1.28
0.61
4.8
4.0
—
—
—
0
0
101
951
1.39
0.61
5.6
3.7
6.77
5.75
mmol/l
3.05
95
897
19
248
0.72
0.59
1.4
1.6
—
—
—
0
0
108
1030
1.49
0.58
6.0
4.1
2.72
2.97
mmol/l
2.49
102
984
22
175
1.31
0.48
1.5
1.3
19.00
23.26
iu/ml
—
6
58
105
1004
1.37
0.47
21.0
10.8
21.03
19.22
mg/l
0.22
81
757
26
213
1.28
0.46
5.4
3.2
0.00
0.00
estimate
—
7
76
8
61
1.33
0.40
1.1
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
1.28
—
0
5
14
174
0.78
0.32
2.2
2.1
—
—
—
0
0
16
192
0.81
0.28
2.1
2.2
—
—
—
0
0
101
979
1.20
0.25
5.3
3.5
1.34
1.35
mmol/l
0.02
95
928
97
1000
0.84
0.24
21.8
11.2
38.00
41.64
%
2.90
83
848
11
89
1.26
0.21
2.5
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
222.42
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
20
174
1.18
0.21
1.4
1.2
1.10
5.84
u/ml
—
6
77
11
133
0.81
0.20
2.6
1.6
—
—
—
0
0
7
58
1.22
0.18
1.4
1.4
—
287.82
—
0
32
5
68
0.72
0.17
1.4
3.0
4.30
4.70
pmol/l
—
5
57
17
189
0.88
0.13
1.5
3.5
25.86
23.18
%
—
5
63
37
349
1.09
0.12
6.0
2.7
—
—
—
0
0
29
271
1.09
0.11
11.1
2.7
—
—
—
0
0
115
1153
0.94
0.09
29.4
15.8
135.01
140.06
g/l
2.63
115
1139
115
1153
0.94
0.09
29.2
15.8
4.55
4.65
e12/l
1.24
115
1127
8
91
0.87
0.07
4.1
5.9
—
—
—
0
0
14
152
0.91
0.06
1.1
2.2
1.02
0.72
ug/l
—
6
72
16
167
0.95
0.01
1.8
1.4
—
—
—
0
0
115
1150
1.00
0.00
29.2
15.8
259.37
256.77
e9/l
0.16
115
1127
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
23.14
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
8.86
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
78
0.89
0.00
2.7
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
46.00
—
0
7
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
12.77
—
0
6
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: WET_AMD_EARLY – Wet age-related macular degeneration, under 50
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).