This is a non-core endpoint: only basic statistics are computed.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
207 |
4. Check minimum number of eventsNone |
207 |
5. Include endpointsNone |
207 |
6. Filter based on genotype QC (FinnGen only) |
207 |
Control definitions (FinnGen only)
- Control exclude
- Z21_ADDIT_CODES_LOCAT_DEFECT_INJURY_ILLNE
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Z[AB]
Similar endpoints
↥List of similar endpoints to
Lower leg
based on the number of shared cases.
Similar with more cases:
- Additional codes for the location of defect, injury or illness
- Factors influencing health status and contact with health services
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 207 | 140 | 67 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 55.71 | 52.08 | 63.30 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 183
- Matched controls
- 1830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ZA6.0
ICD-10 Finland
Lower leg
4503599627370496.0
259.3
182
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
4.1
12.8
56
177
L15
ICPC
Knee symptom/complaint
3.7
12.7
67
248
B01AB05
ATC
enoxaparin; parenteral
3.1
10.7
74
326
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.4
10.3
39
106
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.8
9.0
40
125
M79.6
ICD-10 Finland
Pain in limb
2.7
8.9
85
450
S80.0
ICD-10 Finland
Contusion of knee
5.1
8.1
25
55
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
7.6
86
486
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
4.0
7.5
30
86
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.9
7.4
50
209
R4110
NOMESCO Finland
Physiotherapy
2.6
7.0
62
303
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
5.7
6.3
17
32
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
31
8.22
16.45
1.7
1.5
5499.40
5752.83
e6/l
0.03
15
23
30
57
5.99
15.66
2.1
2.1
—
—
—
0
0
55
176
3.89
15.22
12.4
20.1
1.10
1.13
inr
0.13
16
26
27
54
5.60
13.30
2.2
2.0
—
—
—
0
0
58
251
2.82
9.41
4.0
2.9
4.25
3.02
e6/l
0.25
36
125
199
1693
5.54
8.58
18.8
13.1
21.96
22.27
mg/l
0.05
165
1311
17
36
5.06
7.79
1.4
1.3
—
—
—
0
0
58
280
2.49
7.39
2.8
3.7
156.05
159.34
ng/l
0.01
40
206
53
249
2.52
7.13
1.9
1.8
—
—
—
0
0
96
588
2.18
6.93
4.3
3.1
—
—
—
0
0
55
269
2.42
6.76
3.8
2.7
0.74
1.01
e6/l
0.52
34
143
160
1244
2.26
5.75
4.9
4.1
11.55
11.15
mm/h
0.18
154
1142
76
466
2.00
5.15
4.0
3.0
0.08
0.31
e6/l
3.34
55
347
184
1550
2.68
5.01
17.6
12.4
85.32
84.57
ml/min/173m2
0.17
165
1244
110
770
1.91
5.00
7.8
6.6
1.22
1.22
mmol/l
0.06
101
643
161
1284
2.14
4.99
8.5
7.0
76.11
76.61
u/l
0.06
150
1196
94
633
1.89
4.74
1.7
1.9
105.96
95.88
pmol/l
1.08
50
305
64
387
1.95
4.41
1.7
2.0
1.19
1.15
mg/l
0.03
53
298
67
417
1.90
4.21
2.7
3.0
326.71
6316.65
umol/l
2.04
62
362
122
922
1.79
4.00
5.3
4.3
6.91
6.57
mmol/l
0.72
117
841
25
109
2.47
3.87
1.0
1.3
—
27.21
—
0
7
20
79
2.70
3.76
1.9
1.7
—
—
—
0
0
155
1287
1.81
3.40
4.6
3.9
14.29
14.67
pmol/l
1.10
145
1163
91
655
1.69
3.37
4.7
4.4
36.44
35.84
g/l
0.50
83
610
176
1538
1.96
3.05
4.1
3.7
1.28
1.26
mmol/l
0.15
169
1410
182
1611
2.07
3.01
4.5
4.2
4.54
4.67
mmol/l
1.25
176
1488
50
314
1.78
2.96
1.4
1.3
118.18
27.67
iu/ml
0.44
18
106
6
9
6.82
2.88
1.3
1.2
5.68
5.94
mmol/l
—
6
9
10
31
3.34
2.81
2.4
1.5
—
—
—
0
0
179
1585
1.96
2.81
4.6
4.2
5.90
5.83
mmol/l
0.37
169
1456
93
700
1.60
2.75
6.9
5.8
1.23
1.22
mmol/l
0.88
86
636
61
417
1.66
2.64
2.3
2.0
2.11
2.97
mg/l
4.39
55
362
177
1571
1.87
2.62
5.7
4.6
1.74
1.86
mu/l
0.91
166
1444
182
1635
1.94
2.52
4.9
4.5
2.70
2.76
mmol/l
0.38
172
1503
179
1600
1.88
2.51
4.4
4.1
1.43
1.50
mmol/l
1.42
171
1474
47
304
1.71
2.49
1.4
1.3
1.51
8.69
u/ml
2.33
18
126
167
1467
1.72
2.44
5.8
5.3
39.36
39.45
mmol/mol
0.04
159
1365
100
788
1.52
2.30
3.0
2.7
85.52
87.75
ug/l
0.07
95
718
8
23
3.57
2.29
1.1
1.6
—
—
—
0
0
8
23
3.57
2.29
1.0
1.6
—
—
—
0
0
55
384
1.59
2.15
2.6
2.3
—
—
—
0
0
18
92
2.05
1.97
2.1
1.7
—
—
—
0
0
95
764
1.45
1.87
4.2
4.1
—
—
—
0
0
43
294
1.58
1.83
2.0
2.9
2.47
2.45
mmol/l
0.75
35
257
7
23
3.11
1.81
1.1
1.6
—
—
—
0
0
7
23
3.11
1.81
1.0
1.6
—
—
—
0
0
135
1167
1.45
1.76
3.7
3.4
—
—
—
0
0
7
24
2.98
1.74
1.1
1.6
—
—
—
0
0
7
24
2.98
1.74
1.1
1.6
—
—
—
0
0
56
411
1.50
1.73
3.1
3.0
998.71
1152.01
ng/l
0.21
47
343
119
1007
1.43
1.73
11.3
8.8
3.97
4.00
e9/l
0.06
97
880
59
440
1.48
1.69
3.3
3.8
1.78
10.34
mg/mmol
3.79
34
276
21
121
1.82
1.66
1.1
1.3
75.96
151.03
iu/ml
—
9
50
13
63
2.13
1.63
1.2
1.5
—
—
—
0
0
13
63
2.13
1.63
1.2
1.7
0.23
0.24
g/l
0.45
13
63
13
64
2.10
1.58
1.2
1.7
1.16
1.23
g/l
0.52
13
64
9
37
2.50
1.50
1.6
1.5
—
—
—
0
0
7
29
2.46
1.40
1.1
1.2
—
—
—
0
0
7
29
2.46
1.40
1.1
1.2
—
—
—
0
0
6
24
2.54
1.31
1.2
1.1
—
—
—
0
0
12
62
1.99
1.30
1.6
1.3
—
—
—
0
0
11
56
2.02
1.24
1.6
1.4
—
—
—
0
0
67
538
1.36
1.24
2.1
3.2
2.39
2.35
mmol/l
1.25
59
468
26
175
1.56
1.20
1.9
1.6
—
—
—
0
0
16
96
1.72
1.14
1.9
1.3
—
—
—
0
0
8
40
2.04
1.13
1.5
1.2
—
—
—
0
0
167
1549
1.40
1.12
18.0
13.5
40.35
40.00
%
0.34
137
1165
23
153
1.57
1.12
1.5
1.9
375.33
357.85
nmol/l
0.19
18
142
72
593
1.33
1.12
3.5
3.7
28.93
46.51
ng/l
0.56
41
387
7
31
2.30
1.11
1.4
1.1
0.66
0.91
nmol/l
—
7
25
12
67
1.84
1.07
1.2
1.4
209.20
281.19
miu/ml
—
5
30
97
838
1.30
1.05
4.2
3.7
0.00
0.00
estimate
—
9
164
9
46
2.00
1.05
1.6
1.5
—
—
—
0
0
19
124
1.59
1.01
4.1
2.9
62.22
68.02
ml/min/173m2
—
9
50
38
288
1.39
0.99
2.2
2.1
—
—
—
0
0
45
359
1.32
0.86
5.1
4.5
3.44
2.26
ug/l
0.64
39
313
13
200
0.63
0.85
4.9
6.3
—
—
—
0
0
94
826
1.25
0.85
4.3
3.6
0.00
0.00
estimate
—
8
174
94
827
1.25
0.83
6.1
5.0
0.00
0.00
estimate
—
9
170
6
32
1.90
0.82
1.3
1.5
—
—
—
0
0
48
392
1.29
0.78
2.2
1.6
—
—
—
0
0
0
27
0.00
0.78
0.0
1.6
—
—
—
0
0
12
75
1.64
0.76
2.2
5.7
24.00
24.23
mmol/l
0.09
12
69
35
276
1.32
0.73
4.4
4.3
14.78
21.87
%
2.25
16
127
51
426
1.26
0.70
1.4
1.2
0.46
1.22
u/ml
1.97
13
114
24
180
1.38
0.69
3.8
4.2
272.67
240.23
u/l
0.25
24
171
24
180
1.38
0.69
2.0
1.7
—
—
—
0
0
40
328
1.27
0.64
1.4
1.4
—
—
—
0
0
38
310
1.28
0.63
2.3
2.3
—
—
—
0
0
8
49
1.66
0.63
1.3
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.6
—
—
—
0
0
8
54
1.50
0.58
2.1
1.4
—
—
—
0
0
20
151
1.36
0.56
7.4
6.9
11.16
12.24
kpa
0.77
20
142
20
151
1.36
0.56
7.3
7.0
5.26
5.09
kpa
0.38
20
142
6
40
1.51
0.52
1.8
1.4
—
—
—
0
0
25
199
1.29
0.51
3.5
2.8
0.59
0.80
ug/l
1.36
15
120
11
76
1.47
0.49
2.5
2.6
2.10
1.30
%
0.67
11
76
16
120
1.36
0.48
3.4
4.2
4.90
4.44
kpa
0.90
16
115
13
94
1.41
0.47
9.3
7.3
24.25
25.12
mmol/l
0.52
13
94
7
51
1.39
0.44
1.3
1.2
—
—
—
0
0
5
32
1.58
0.42
1.4
2.3
—
—
—
0
0
11
149
0.72
0.41
1.2
1.6
—
—
—
0
0
5
33
1.53
0.41
1.2
1.5
—
95.00
—
0
7
0
18
0.00
0.40
0.0
3.4
—
—
—
0
0
13
98
1.35
0.38
1.9
2.3
5500.44
4402.02
u/l
—
8
35
6
42
1.44
0.36
1.3
1.4
—
—
—
0
0
44
391
1.16
0.33
1.5
1.5
20.08
21.62
nmol/l
0.38
38
331
6
46
1.31
0.33
1.7
1.5
—
—
—
0
0
7
52
1.36
0.31
1.3
1.2
—
—
—
0
0
70
650
1.12
0.28
4.2
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
372.33
—
0
6
0
12
0.00
0.21
0.0
1.1
—
42.83
—
0
6
11
132
0.82
0.19
2.5
1.8
—
—
—
0
0
7
62
1.13
0.17
2.0
2.5
—
—
—
0
0
12
103
1.18
0.14
1.2
1.0
—
—
—
0
0
10
117
0.85
0.13
1.2
1.5
—
—
—
0
0
18
164
1.11
0.10
2.7
4.0
4.52
7.93
ug/l
0.48
12
128
5
46
1.09
0.09
1.8
2.3
—
—
—
0
0
27
288
0.93
0.09
1.8
1.6
1163.28
1223.42
nmol/l
0.13
18
210
5
63
0.79
0.08
3.0
1.9
—
—
—
0
0
23
216
1.07
0.07
2.6
2.3
24.22
23.26
%
0.11
18
185
16
172
0.92
0.06
2.6
2.0
—
—
—
0
0
15
159
0.94
0.03
2.8
3.4
—
—
—
0
0
12
116
1.04
0.00
1.5
1.3
—
—
—
0
0
44
437
1.01
0.00
1.7
1.6
1.27
1.35
mmol/l
0.47
38
369
0
9
0.00
0.00
0.0
5.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
5.5
—
225.75
—
0
8
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.3
—
81.67
—
0
6
44
440
1.00
0.00
4.5
3.9
0.00
0.00
estimate
—
8
172
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
7
70
1.00
0.00
1.3
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
3.5
—
20.73
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
7.18
—
0
8
6
69
0.87
0.00
4.8
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1778.20
—
0
5
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
0.00
1.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: Z21_LOWER_LEG – Lower leg
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).