This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Other problems related to upbringing
Z21_OTHER_PROBL_RELATED_UPBRI
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
179 |
4. Check minimum number of eventsNone |
179 |
5. Include endpointsNone |
179 |
6. Filter based on genotype QC (FinnGen only) |
179 |
Control definitions (FinnGen only)
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- Z5[5-9]|Z6
Similar endpoints
↥List of similar endpoints to
Other problems related to upbringing
based on the number of shared cases.
Similar with more cases:
- Persons with potential health hazards related to socioeconomic and psychosocial circumstances
- Factors influencing health status and contact with health services
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 179 | 131 | 48 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | 14.55 | 14.96 | 13.43 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 164
- Matched controls
- 1640
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z62.8
ICD-10 Finland
Other specified problems related to upbringing
+∞
53.0
48
*
Z62.2
ICD-10 Finland
Institutional upbringing
+∞
43.7
40
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
8.2
31.5
89
208
Z62.0
ICD-10 Finland
Inadequate parental supervision and control
+∞
30.1
28
*
N05AH04
ATC
quetiapine; oral
7.0
26.6
82
205
Z62.9
ICD-10 Finland
Problem related to upbringing, unspecified
+∞
22.4
21
*
F93.89
ICD-10 Finland
Other childhood emotional disorders
19.3
21.7
33
21
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
17.9
19.9
31
21
T36
ICD-10 Finland
Poisoning by systemic antibiotics
9.5
18.6
40
54
N05AX08
ATC
risperidone; systemic
10.7
18.2
36
42
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.2
17.7
66
189
Z62.4
ICD-10 Finland
Emotional neglect of child
+∞
17.0
16
*
Z61.8
ICD-10 Finland
Other negative life events in childhood
+∞
17.0
16
*
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
53.3
16.4
19
*
N06AX11
ATC
mirtazapine; oral
4.4
15.9
72
247
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
94.3
15.9
17
*
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
176.1
15.8
16
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
7.3
14.4
36
61
Z63.2
ICD-10 Finland
Inadequate family support
+∞
13.7
13
*
F92.0
ICD-10 Finland
Depressive conduct disorder
23.5
12.3
17
8
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.3
12.1
27
38
N03AX09
ATC
lamotrigine; oral
6.7
11.6
30
53
N05AX12
ATC
aripiprazole; systemic
7.0
11.6
29
49
N05AH03
ATC
olanzapine; systemic
6.0
11.0
31
61
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
15.6
10.8
17
12
Z10.1
ICD-10 Finland
Routine general health check-up of inhabitants of institutions
117.2
10.5
11
*
N05CF01
ATC
zopiclone; oral
4.2
10.5
43
128
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.6
10.4
54
195
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.8
10.4
49
165
F29
ICD-10 Finland
Unspecified nonorganic psychosis
6.1
9.9
27
51
N06AB04
ATC
citalopram; systemic
4.0
9.8
42
129
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
12.5
9.8
17
15
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.8
9.6
33
82
N05AA02
ATC
levomepromazine; systemic
13.5
9.6
16
13
N05AH02
ATC
clozapine; systemic
10.5
9.5
18
19
Z63.8
ICD-10 Finland
Other specified problems related to primary support group
105.9
9.5
10
*
F91.3
ICD-10 Finland
Oppositional defiant disorder
+∞
9.5
9
*
Z63.5
ICD-10 Finland
Disruption of family by separation and divorce
+∞
9.5
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
9.3
85
452
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
7.6
9.2
21
31
N05AF03
ATC
chlorprothixene; systemic
13.6
9.1
15
12
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
7.4
9.0
21
32
N06AB03
ATC
fluoxetine; oral
4.4
8.9
33
88
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
6.3
8.8
23
41
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.6
8.8
43
147
R51.80
ICD-10 Finland
Headache
3.3
8.6
49
187
Z29
ICPC
Social problem NOS
9.3
8.5
17
20
N05BA04
ATC
oxazepam; oral
3.2
8.4
50
198
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
6.5
8.3
21
36
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
10.9
8.2
15
15
C07AA05
ATC
propranolol; systemic
3.1
7.9
49
196
C07AB07
ATC
bisoprolol; oral
3.7
7.8
36
117
F91.9
ICD-10 Finland
Conduct disorder, unspecified
47.3
7.8
9
*
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
19.5
7.7
11
6
X59
ICD-10 Finland
Exposure to unspecified factor
3.2
7.7
43
163
F90.0
ICD-10 Finland
Disturbance of activity and attention
4.1
7.5
29
81
F43.1
ICD-10 Finland
Post-traumatic stress disorder
6.8
7.5
18
29
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
7.9
7.4
16
22
F94.1
ICD-10 Finland
Reactive attachment disorder of childhood
+∞
7.3
7
*
N06AX12
ATC
bupropion; oral
4.3
7.1
26
69
F39
ICD-10 Finland
Unspecified mood [affective] disorder
7.3
7.0
16
24
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.6
6.9
63
321
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.0
6.7
26
73
N03AG01
ATC
valproic acid; systemic, rectal
5.0
6.6
20
44
P99
ICPC
Psychological disorders other
6.4
6.5
16
27
F61.0
ICD-10 Finland
Mixed personality disorders
15.1
6.5
10
7
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
15.1
6.5
10
7
P01AB01
ATC
metronidazole; oral, rectal
2.5
6.4
60
308
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
7.5
6.4
14
20
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
5.8
6.4
17
32
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.9
6.3
40
163
T51.0
ICD-10 Finland
Toxic effect: Ethanol
27.9
6.3
8
*
Z61.6
ICD-10 Finland
Problems related to alleged physical abuse of child
+∞
6.3
6
*
Z61.7
ICD-10 Finland
Personal frightening experience in childhood
+∞
6.3
6
*
Z62.1
ICD-10 Finland
Parental overprotection
+∞
6.3
6
*
Z61.2
ICD-10 Finland
Altered pattern of family relationships in childhood
+∞
6.3
6
*
N03AX16
ATC
pregabalin; oral
3.5
6.2
29
95
Z71.8
ICD-10 Finland
Other specified counselling
2.4
6.2
63
336
F32.8
ICD-10 Finland
Other depressive episodes
9.1
6.2
12
14
F60.9
ICD-10 Finland
Personality disorder, unspecified
13.2
6.2
10
8
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.6
6.0
27
86
J01MA02
ATC
ciprofloxacin; systemic
2.6
6.0
48
224
N06AB06
ATC
sertraline; oral
3.2
6.0
33
121
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
132
829
3.26
11.35
6.9
5.0
79.58
74.81
u/l
0.56
125
771
95
499
2.93
11.34
4.3
4.2
8.43
10.33
umol/l
1.47
90
457
78
374
2.92
10.94
3.6
2.8
—
—
—
0
0
56
237
2.98
9.69
2.2
1.4
1.56
1.39
%
2.30
50
220
66
309
2.80
9.44
3.6
2.6
0.23
0.15
e6/l
0.42
50
231
45
176
3.08
8.87
2.7
2.4
7.62
3.98
e6/l
0.97
25
89
44
172
3.07
8.67
2.8
2.4
0.58
0.56
e6/l
0.04
23
86
25
68
4.11
8.52
3.7
9.1
106.04
105.57
mmol/l
0.22
25
68
80
432
2.54
8.41
5.5
6.2
1.22
1.22
mmol/l
0.00
68
369
66
328
2.60
8.22
4.1
2.4
50.64
55.48
u/l
0.94
58
300
150
1105
3.21
8.11
5.3
3.9
14.46
14.31
pmol/l
0.30
142
1015
116
765
2.47
7.63
19.0
7.3
4.65
3.94
e9/l
2.03
103
667
133
948
2.57
7.16
3.8
2.4
32.77
26.48
u/l
1.44
124
907
11
9
12.92
6.67
1.5
1.3
—
—
—
0
0
160
1281
3.35
6.34
6.2
4.3
1.84
1.71
mu/l
0.67
155
1217
65
355
2.30
6.32
1.6
1.5
102.01
94.76
pmol/l
0.66
37
190
104
688
2.22
6.32
2.9
2.5
—
—
—
0
0
96
636
2.10
5.58
2.6
2.3
—
—
—
0
0
30
120
2.80
5.56
1.5
1.5
1106.09
1077.90
nmol/l
0.06
23
101
145
1136
2.46
5.40
4.4
2.4
5.61
5.40
mmol/l
1.19
137
1035
97
658
2.04
5.15
5.2
4.7
6.21
6.10
mmol/l
0.21
87
544
27
112
2.66
4.66
3.3
2.2
26.47
29.72
u/l
0.66
19
95
17
54
3.37
4.62
1.4
1.3
—
—
—
0
0
42
215
2.25
4.61
1.3
1.2
19.36
19.30
nmol/l
0.01
37
195
10
21
4.98
4.59
3.9
2.9
51.07
51.60
%
—
10
21
168
1452
3.56
4.48
10.0
6.3
29.84
24.68
u/l
2.09
162
1397
101
720
1.92
4.41
4.3
4.1
0.00
0.00
estimate
0.00
20
179
144
1163
2.22
4.38
11.6
6.3
107.52
106.60
ml/min/173m2
0.22
119
863
7
6
12.07
4.31
1.4
3.8
12.90
19.95
umol/l
—
7
6
100
717
1.89
4.22
3.3
2.9
0.00
0.00
estimate
0.00
20
171
15
47
3.39
4.16
1.7
1.1
—
—
—
0
0
15
48
3.32
4.03
1.7
1.1
—
—
—
0
0
119
911
1.91
4.02
4.7
3.0
36.50
36.16
mmol/mol
0.15
112
856
100
728
1.85
3.92
3.4
3.0
0.00
0.00
estimate
0.00
22
172
77
517
1.86
3.92
2.7
2.2
66.25
68.38
nmol/l
0.32
68
476
6
5
12.35
3.79
1.3
2.8
77.50
153.40
nmol/l
—
6
5
164
1426
2.79
3.79
14.9
8.5
19.08
19.83
mg/l
0.13
145
1066
80
553
1.81
3.64
3.3
3.0
—
—
—
0
0
11
31
3.72
3.54
4.1
11.6
92.00
95.56
%
1.96
11
31
14
47
3.15
3.50
1.7
1.5
—
—
—
0
0
141
1168
1.98
3.45
3.4
2.4
1.33
1.46
mmol/l
2.89
130
1104
20
83
2.59
3.45
9.7
3.8
—
—
—
0
0
24
109
2.39
3.44
1.9
1.5
—
—
—
0
0
47
282
1.90
3.31
1.9
2.0
28.97
17.06
ng/l
0.32
15
90
141
1176
1.94
3.27
3.5
2.5
4.41
4.55
mmol/l
1.14
131
1109
21
92
2.45
3.25
1.8
1.4
—
—
—
0
0
10
29
3.59
3.09
2.8
12.3
0.53
0.75
%
—
10
29
10
29
3.59
3.09
2.8
12.3
3.12
1.27
%
—
10
29
32
172
2.05
3.06
3.2
1.7
—
—
—
0
0
23
108
2.30
3.06
2.0
1.4
—
—
—
0
0
140
1176
1.87
3.03
3.7
2.5
2.75
2.75
mmol/l
0.02
129
1102
30
162
2.02
2.84
1.8
1.6
—
—
—
0
0
47
301
1.76
2.65
3.3
2.3
2.35
2.36
mmol/l
0.35
40
270
132
1108
1.73
2.64
3.2
2.3
1.25
1.12
mmol/l
1.40
123
1050
26
137
2.05
2.62
1.7
2.3
3.96
9.37
umol/l
0.97
21
108
7
15
4.81
2.62
3.1
1.5
24.20
23.31
mmol/l
—
7
15
8
20
4.14
2.60
1.5
1.1
—
—
—
0
0
52
346
1.71
2.55
1.9
2.0
2.50
2.43
mg/l
0.11
47
293
15
64
2.47
2.46
3.7
6.5
24.21
25.29
mmol/l
1.35
15
64
57
396
1.64
2.36
3.6
3.1
0.00
0.01
estimate
0.50
20
176
5
9
5.68
2.23
1.0
1.0
—
—
—
0
0
8
193
0.39
2.21
1.8
1.7
—
—
—
0
0
23
125
1.96
2.15
1.6
1.4
247.16
297.59
miu/ml
—
10
67
35
219
1.74
2.12
1.1
1.3
10.60
17.47
iu/ml
—
5
52
27
156
1.86
2.11
1.6
1.3
—
—
—
0
0
13
56
2.42
2.10
2.2
1.6
—
—
—
0
0
15
71
2.21
1.98
1.8
1.5
—
—
—
0
0
8
29
2.84
1.81
1.4
1.1
3.44
3.68
mmol/l
—
8
29
64
483
1.51
1.80
1.5
1.4
0.52
2.31
u/ml
1.13
21
116
38
257
1.61
1.72
2.7
2.6
4419.42
3465.53
u/l
—
9
118
23
137
1.78
1.65
1.1
1.0
—
—
—
0
0
27
408
0.60
1.64
1.5
1.5
—
—
—
0
0
8
32
2.57
1.62
1.0
1.1
—
—
—
0
0
6
21
2.92
1.52
1.0
1.1
—
—
—
0
0
6
21
2.92
1.52
1.0
1.1
—
—
—
0
0
14
73
2.00
1.48
1.6
1.2
—
—
—
0
0
11
208
0.50
1.44
1.5
1.6
—
—
—
0
0
24
151
1.68
1.44
4.3
4.8
63.71
24.25
mg/mmol
0.28
16
109
18
104
1.81
1.43
1.7
1.2
52.64
486.73
u/ml
1.20
18
96
13
68
1.98
1.37
1.6
1.3
—
—
—
0
0
9
167
0.51
1.26
1.4
1.5
—
—
—
0
0
10
49
2.10
1.24
1.6
2.0
84.80
92.24
ml/min/173m2
—
5
17
39
288
1.45
1.19
1.8
1.8
0.78
0.71
mg/l
0.12
26
192
39
290
1.44
1.15
2.0
2.0
—
—
—
0
0
21
140
1.57
1.03
1.6
2.4
13.20
358.34
ng/l
—
5
50
76
645
1.31
0.98
2.3
1.8
—
—
—
0
0
11
62
1.82
0.96
1.1
1.2
—
—
—
0
0
6
28
2.18
0.92
1.2
1.1
—
—
—
0
0
13
79
1.70
0.91
1.7
1.6
—
—
—
0
0
50
405
1.33
0.89
1.6
1.5
—
—
—
0
0
11
175
0.60
0.83
1.4
1.3
—
—
—
0
0
14
91
1.58
0.78
4.7
2.2
—
—
—
0
0
0
28
0.00
0.77
0.0
1.6
—
—
—
0
0
29
221
1.37
0.76
1.1
1.2
0.88
7.96
u/ml
1.89
12
96
76
668
1.24
0.69
4.0
4.5
—
—
—
0
0
21
276
0.73
0.64
1.3
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
5.0
—
4.42
—
0
17
25
195
1.33
0.58
1.7
2.3
342.40
2140.41
umol/l
0.48
20
179
21
161
1.34
0.55
1.1
1.3
374.58
112.84
iu/ml
—
5
63
42
366
1.19
0.40
2.4
1.7
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
8
61
1.33
0.40
1.6
1.6
—
—
—
0
0
6
46
1.31
0.33
1.2
1.4
—
—
—
0
0
50
453
1.14
0.30
2.8
1.9
—
—
—
0
0
18
216
0.81
0.30
1.7
1.5
—
—
—
0
0
152
1485
1.16
0.24
18.7
9.2
40.76
40.53
%
0.26
119
1273
147
1503
0.88
0.23
4.7
4.3
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
10
0.00
0.21
0.0
1.1
—
129.50
—
0
10
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
5
66
0.75
0.17
1.0
1.0
—
9.83
—
0
11
5
45
1.11
0.10
1.0
1.2
—
—
—
0
0
19
196
0.97
0.00
1.6
1.5
—
—
—
0
0
19
195
0.97
0.00
1.6
1.5
—
—
—
0
0
19
195
0.97
0.00
1.6
1.5
—
—
—
0
0
19
195
0.97
0.00
1.6
1.5
—
—
—
0
0
5
54
0.92
0.00
3.6
2.2
0.62
1.48
ug/l
—
5
48
0
7
0.00
0.00
0.0
1.0
—
848.86
—
0
7
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.8
—
11.35
—
0
8
0
8
0.00
-0.00
0.0
2.6
—
105.13
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: Z21_OTHER_PROBL_RELATED_UPBRI – Other problems related to upbringing
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).