aspergillosis: Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma , a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess , is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
130 |
4. Check minimum number of eventsNone |
130 |
5. Include endpointsNone |
130 |
6. Filter based on genotype QC (FinnGen only) |
130 |
Control definitions (FinnGen only)
- Control exclude
- ASTHMA_COMORB
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- B44
- Name in latin
- Aspergillosis pulmonalis
Similar endpoints
↥List of similar endpoints to
Allergic bronchopulmonary aspergillosis (ABPA)
based on the number of shared cases.
Similar with more cases:
- Aspergillosis
- Mycoses
- Certain infectious and parasitic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 699 | 250 | 439 |
| Only index persons | 549 | 205 | 344 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.91 | 66.25 | 65.77 |
| Only index persons | 65.36 | 65.64 | 65.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 130 | 48 | 82 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 63.64 | 58.06 | 66.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 115
- Matched controls
- 1149
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
+∞
150.4
109
*
J02AC03
ATC
voriconazole; systemic
+∞
57.1
50
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
32.2
55.7
88
105
UGC12
NOMESCO Finland
Flexible bronchoscopy
39.4
48.6
63
34
H02AB06
ATC
prednisolone; systemic
25.6
42.7
103
288
GD1AA
NOMESCO Finland
Thorax X-ray examination
19.2
41.3
95
227
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
23.5
38.6
59
49
TGC00
NOMESCO Finland
Bronchial lavation
100.5
37.9
40
6
J01MA14
ATC
moxifloxacin; systemic
23.9
37.8
57
45
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
39.3
36.5
46
19
R03BB04
ATC
tiotropium bromide; inhalant
23.4
36.4
55
43
J01MA12
ATC
levofloxacin; systemic
16.0
35.2
66
89
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
31.0
34.1
46
24
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
31.2
33.5
45
23
J45.9
ICD-10 Finland
Asthma, unspecified
16.6
32.3
57
64
J47
ICD-10 Finland
Bronchiectasis
145.9
31.5
32
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
57.1
31.2
36
9
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
39.7
30.4
38
14
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
19.7
30.3
48
40
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
11.9
28.5
61
99
R03AK06
ATC
salmeterol and fluticasone; inhalant
14.9
28.1
51
58
J45.0
ICD-10 Finland
Predominantly allergic asthma
20.4
25.5
39
28
R03BA05
ATC
fluticasone; inhalant
11.4
25.1
53
80
H25.1
ICD-10 Finland
Senile nuclear cataract
39.8
24.2
30
10
J45.1
ICD-10 Finland
Nonallergic asthma
18.9
23.6
37
28
R04.2
ICD-10 Finland
Haemoptysis
28.4
22.2
30
14
R03AC12
ATC
salmeterol; inhalant
29.3
21.7
29
13
B44.0
ICD-10 Finland
Invasive pulmonary aspergillosis
+∞
21.5
20
*
R03AC02
ATC
salbutamol; inhalant
7.3
21.2
85
322
GD1AD
NOMESCO Finland
Thorax CT examination
25.3
20.8
29
15
B44.9
ICD-10 Finland
Aspergillosis, unspecified
+∞
20.4
19
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
23.7
20.4
29
16
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.2
20.0
61
156
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
6.7
19.7
84
331
R03DC03
ATC
montelukast; oral
9.5
19.5
44
70
R03DA04
ATC
theophylline; systemic, rectal
17.2
19.4
31
24
B44.8
ICD-10 Finland
Other forms of aspergillosis
+∞
19.3
18
*
R03AK08
ATC
formoterol and beclometasone; inhalant
23.5
18.3
26
14
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
19.0
18.3
28
19
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
26.1
18.2
25
12
H02AB04
ATC
methylprednisolone; systemic
9.2
18.1
41
65
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
210.8
18.0
18
*
R03BA01
ATC
beclometasone; inhalant
9.0
17.5
40
64
J01FA06
ATC
roxithromycin; oral
5.8
17.4
68
228
A02BC02
ATC
pantoprazole; systemic
6.2
17.1
90
420
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
12.2
17.1
32
35
XF400
NOMESCO Finland
ECG with 12 standard connections
9.6
17.0
37
54
R50.9
ICD-10 Finland
Fever, unspecified
9.6
16.2
35
50
I25.1
ICD-10 Finland
Atherosclerotic heart disease
98.7
16.0
17
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.6
15.6
46
105
M05BA04
ATC
alendronic acid; oral
17.4
15.4
24
17
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
14.2
15.2
26
23
R06.0
ICD-10 Finland
Dyspnoea
6.3
15.1
46
109
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
20.5
15.0
22
13
I48
ICD-10 Finland
Atrial fibrillation and flutter
42.1
14.9
18
5
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
9.9
14.9
31
41
215
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
14.9
14
*
103
Kela drug reimbursment
Diabetes, insulin-treated
170.5
14.8
15
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
17.6
14.8
23
16
XG410
NOMESCO Finland
Flow-volume spirometry
23.8
14.4
20
10
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.5
14.1
30
41
J01FF01
ATC
clindamycin; systemic
5.5
14.1
50
141
R03AC13
ATC
formoterol; inhalant
19.4
14.1
21
13
JN4BD
NOMESCO Finland
Extensive body CT
7.6
14.1
35
62
R81
ICPC
Pneumonia
30.1
13.8
18
7
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
7.0
13.5
36
70
J45.8
ICD-10 Finland
Mixed asthma
32.8
13.4
17
6
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
26.3
13.4
18
8
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
11.1
13.1
25
28
J45
ICD-10 Finland
Asthma
9.8
12.7
26
33
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
10.3
12.6
25
30
J46
ICD-10 Finland
Status asthmaticus
42.6
12.5
15
*
R03BA02
ATC
budesonide; inhalant
6.2
12.5
37
82
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
6.9
12.5
33
63
J01FA09
ATC
clarithromycin; systemic
4.8
12.4
50
158
C03CA01
ATC
furosemide; systemic
5.7
12.2
39
95
TPH04
NOMESCO Finland
Cathetrisation of vein
5.7
12.2
39
95
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
52.5
12.2
14
*
AA1AD
NOMESCO Finland
CT of head and brain
5.9
12.1
37
85
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.8
12.0
48
150
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
132.5
11.6
12
*
J01AA02
ATC
doxycycline; systemic
5.5
11.2
101
650
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
7.2
11.2
28
49
GDC00
NOMESCO Finland
Lobectomy of lung
48.3
11.2
13
*
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
20.3
11.1
16
9
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
6.5
11.0
30
59
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
24.3
11.0
15
7
R03BA08
ATC
ciclesonide; inhalant
8.6
11.0
24
34
H02AB07
ATC
prednisone; oral
6.6
10.8
29
56
J01FA10
ATC
azithromycin; systemic
3.8
10.7
75
378
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
120.3
10.6
11
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
36.2
10.6
13
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
10.6
10
*
N03AX16
ATC
pregabalin; oral
5.0
10.5
37
99
WX408
NOMESCO Finland
General anesthesy, balanced
4.2
10.5
48
167
WX892
NOMESCO Finland
Monitored bed care
11.7
10.5
19
19
ZX120
NOMESCO Finland
Intravenous
7.9
10.4
24
37
49300
ICD-8 Finland
Asthma, bronchiale
18.9
10.2
15
9
127
Kela drug reimbursment
Transplant complication
44.1
10.2
12
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
44.1
10.2
12
*
C07AB07
ATC
bisoprolol; oral
4.0
10.0
49
178
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.6
9.6
29
65
A10AE04
ATC
insulin glargine; parenteral
108.4
9.6
10
*
A02BC01
ATC
omeprazole; systemic
4.2
9.6
42
139
B01AA03
ATC
warfarin; systemic
7.3
9.5
23
38
J17.2*B44.1
ICD-10 Finland
Pneumonia in other aspergillosis
+∞
9.5
9
*
J02AC04
ATC
posaconazole; systemic
+∞
9.5
9
*
WX002
NOMESCO Finland
Sedation and analgesia
4.8
9.4
34
93
J01.0
ICD-10 Finland
Acute maxillary sinusitis
4.6
9.2
35
100
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
40.1
9.2
11
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
40.1
9.2
11
*
Z01.8
ICD-10 Finland
Other specified special examinations
4.5
9.1
35
101
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.3
8.9
36
109
XW000
NOMESCO Finland
Bone marrow biopsy
13.0
8.9
15
13
N02BE01
ATC
paracetamol; systemic, rectal
4.6
8.8
101
700
R03AK07
ATC
formoterol and budesonide; inhalant
4.6
8.7
32
88
J01CA04
ATC
amoxicillin; systemic
4.0
8.7
96
639
A02BC05
ATC
esomeprazole; systemic
3.4
8.6
55
242
R03BB01
ATC
ipratropium bromide; inhalant
12.1
8.6
15
14
207
Kela drug reimbursment
Chronic arrhythmias
96.7
8.5
9
*
H26.4
ICD-10 Finland
After-cataract
96.7
8.5
9
*
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
96.7
8.5
9
*
ZXA05
NOMESCO Finland
Left side
4.1
8.5
36
114
WX302
NOMESCO Finland
Thoracal epidural anesthesy
9.3
8.4
17
21
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
8.4
8
*
J01FA15
ATC
telithromycin; oral
5.8
8.4
24
50
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
13.1
8.3
14
12
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
18.9
8.3
12
7
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
36.1
8.2
10
*
H25.8
ICD-10 Finland
Other senile cataract
36.1
8.2
10
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
8.0
8.1
18
26
J02AC01
ATC
fluconazole; systemic
3.4
8.1
49
207
A07AA02
ATC
nystatin; oral
7.7
8.0
18
27
UDH02
NOMESCO Finland
Rhinopharyngoscopy
9.1
7.9
16
20
J01MA02
ATC
ciprofloxacin; systemic
3.2
7.9
55
256
A02BC03
ATC
lansoprazole; oral
3.7
7.9
40
145
L04AA06
ATC
mycophenolic acid; systemic
48.2
7.8
9
*
WW200
NOMESCO Finland
Immunization
20.0
7.8
11
6
N02AA05
ATC
oxycodone; systemic
4.4
7.8
29
81
TPH07
NOMESCO Finland
Cathetrisation of artery
6.0
7.7
21
41
R49.01
ICD-10 Finland
Functional dysphonia
27.0
7.7
10
*
JN4CD
NOMESCO Finland
Very extensive body CT
7.8
7.6
17
25
R01AD09
ATC
mometasone; nasal
3.1
7.6
57
277
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
14.7
7.6
12
9
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
14.7
7.6
12
9
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
85.2
7.5
8
*
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
85.2
7.5
8
*
I50.9
ICD-10 Finland
Heart failure, unspecified
12.0
7.5
13
12
A28
ICPC
Limited function/disability NOS
5.7
7.4
21
43
R4110
NOMESCO Finland
Physiotherapy
3.5
7.4
40
153
XG474
NOMESCO Finland
Exhalation nntrogen oxide
17.1
7.4
11
7
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
17.1
7.4
11
7
J85.2
ICD-10 Finland
Abscess of lung without pneumonia
+∞
7.4
7
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
7.4
7
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
21.7
7.3
10
5
P01BA02
ATC
hydroxychloroquine; oral
13.2
7.3
12
10
A41.9
ICD-10 Finland
Sepsis, unspecified
32.2
7.3
9
*
R03AC03
ATC
terbutaline; inhalant
4.9
7.3
24
59
B01AB05
ATC
enoxaparin; parenteral
3.4
7.2
41
162
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
6.5
7.1
18
32
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.4
7.1
38
144
TDM10
NOMESCO Finland
Puncture of maxillary antrum
9.2
7.1
14
17
J01DB01
ATC
cefalexin; oral
3.3
7.0
93
642
B01AC04
ATC
clopidogrel; oral
10.3
7.0
13
14
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
12.0
7.0
12
11
A10BA02
ATC
metformin; oral
18.0
6.9
10
6
H02AB09
ATC
hydrocortisone; systemic
18.0
6.9
10
6
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
18.0
6.9
10
6
R03DC01
ATC
zafirlukast; oral
24.1
6.8
9
*
L04AD01
ATC
ciclosporin; systemic
24.1
6.8
9
*
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
24.1
6.8
9
*
R03AK11
ATC
formoterol and fluticasone; inhalant
13.3
6.7
11
9
WX100
NOMESCO Finland
Conjunctival surface anesthesia
13.3
6.7
11
9
C01DA14
ATC
isosorbide mononitrate; oral
11.0
6.7
12
12
ZXA10
NOMESCO Finland
Bilateral
4.4
6.6
24
65
A01AB04
ATC
amphotericin B; local oral
9.0
6.5
13
16
Z96.1
ICD-10 Finland
Presence of intraocular lens
9.0
6.5
13
16
WX872
NOMESCO Finland
Intensive care
15.4
6.5
10
7
A08
ICPC
Swelling
15.4
6.5
10
7
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
73.6
6.5
7
*
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
12.0
6.4
11
10
SPAT1255
SPAT
Intravenous administration of medicine
7.8
6.4
14
20
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
28.3
6.3
8
*
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
+∞
6.3
6
*
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
+∞
6.3
6
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
6.3
6
*
J96.0
ICD-10 Finland
Acute respiratory failure
+∞
6.3
6
*
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
+∞
6.3
6
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
+∞
6.3
6
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
6.2
6.3
16
29
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
6.2
6.3
16
29
R01AD01
ATC
beclometasone; nasal
4.0
6.2
25
75
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
64
26
47.52
96.76
7.1
3.2
—
—
—
0
0
38
18
29.42
52.58
2.5
1.0
—
—
—
0
0
69
102
13.29
50.22
3.9
1.5
—
—
—
0
0
57
68
14.15
48.19
3.0
1.3
—
—
—
0
0
56
70
13.30
45.62
3.1
1.3
—
—
—
0
0
31
13
31.00
44.52
3.3
1.5
—
—
—
0
0
30
12
32.20
43.76
3.3
1.5
—
—
—
0
0
44
56
11.37
34.64
5.6
9.3
2.2
0.7
mmol/l
1.21
36
48
32
5
83.90
29.50
7.6
2.8
—
—
—
0
0
30
28
13.63
28.87
2.5
1.9
—
—
—
0
0
22
15
17.45
25.10
1.4
1.1
—
—
—
0
0
27
5
67.41
24.13
2.1
1.2
—
—
—
0
0
52
123
6.38
22.77
2.4
1.6
3.4
2.9
mg/l
0.62
45
105
90
351
6.08
22.13
13.1
5.6
1.2
1.2
mmol/l
3.29
84
295
26
9
35.61
20.58
1.9
1.4
—
—
—
0
0
17
11
17.63
19.71
1.8
1.2
—
—
—
0
0
17
11
17.63
19.71
1.8
1.2
—
—
—
0
0
70
245
5.02
18.92
2.5
1.8
78.4
79.5
nmol/l
0.11
64
211
22
6
43.63
18.28
2.0
1.2
—
—
—
0
0
22
7
37.37
17.70
1.5
1.6
—
—
—
0
0
23
9
30.67
17.62
3.5
1.3
—
—
—
0
0
46
120
5.38
17.60
3.7
2.0
410.9
213.5
ng/l
0.31
40
79
18
16
12.90
17.48
1.8
1.4
—
—
—
0
0
21
24
10.24
17.27
1.6
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
17
12.13
16.81
3.2
2.4
0.2
0.3
u/ml
—
9
7
21
7
35.35
16.71
1.5
1.6
—
—
—
0
0
15
12
14.00
15.41
1.7
2.5
—
—
—
0
0
58
208
4.23
14.47
7.9
3.3
28.1
34.6
u/l
1.08
58
202
65
274
3.74
12.49
4.5
2.4
—
—
—
0
0
15
17
9.84
12.25
1.7
1.2
113.4
144.4
g/l
—
8
10
54
205
3.80
12.08
4.5
2.5
0.8
0.5
e6/l
0.21
45
146
15
18
9.29
11.73
2.3
2.1
—
—
—
0
0
15
6
27.98
11.43
3.1
1.2
—
—
—
0
0
14
16
9.69
11.33
3.2
1.3
88.2
89.5
%
0.06
14
16
15
7
23.98
10.96
4.1
1.6
—
—
—
0
0
15
7
23.98
10.96
4.1
1.6
—
—
—
0
0
63
282
3.39
10.66
2.3
1.5
97.1
102.0
pmol/l
0.38
43
147
21
43
5.63
10.19
2.9
1.4
—
—
—
0
0
12
13
10.07
10.03
3.3
1.3
232.7
178.4
%
1.16
12
13
16
27
6.62
9.37
7.2
12.5
25.8
25.0
mmol/l
0.23
16
27
12
15
8.71
9.01
6.2
3.3
425.7
424.3
ug/l
0.00
12
15
35
120
3.62
8.81
4.3
2.5
0.2
1.4
e6/l
0.81
25
66
12
6
21.83
8.64
3.9
1.3
—
—
—
0
0
12
6
21.83
8.64
3.9
1.3
—
—
—
0
0
12
6
21.83
8.64
3.9
1.3
—
—
—
0
0
55
256
2.99
8.30
4.2
1.9
36.1
21.3
ng/l
0.50
47
168
32
112
3.46
7.74
1.6
1.4
1030.3
1081.4
nmol/l
0.12
25
81
34
127
3.27
7.39
4.4
2.3
0.6
0.9
e6/l
0.28
24
70
7
0
+∞
7.35
1.9
0.0
—
—
—
0
0
69
398
2.56
6.49
7.7
3.5
—
—
—
0
0
9
5
19.16
6.36
1.3
1.2
—
—
—
0
0
43
199
2.73
6.31
5.8
2.1
—
—
—
0
0
6
0
+∞
6.29
1.8
0.0
—
—
—
0
0
6
0
+∞
6.29
1.8
0.0
—
—
—
0
0
29
108
3.17
6.27
1.7
1.5
473.8
102247605.6
pmol/l
0.49
24
89
40
180
2.77
6.18
6.5
2.0
342.4
16802.3
umol/l
2.05
33
161
10
9
11.91
5.90
1.5
1.9
—
—
—
0
0
76
482
2.39
5.52
3.4
2.3
—
—
—
0
0
9
8
11.97
5.38
1.3
1.3
—
—
—
0
0
5
0
+∞
5.24
1.2
0.0
—
—
—
0
0
12
30
4.31
4.55
6.4
1.9
—
—
—
0
0
12
31
4.16
4.36
4.4
13.7
0.7
0.7
%
0.19
12
31
12
31
4.16
4.36
4.4
13.8
1.3
1.2
%
0.34
12
31
12
31
4.16
4.36
4.4
13.8
94.0
95.5
%
0.85
12
31
7
6
12.23
4.32
2.1
2.3
—
—
—
0
0
7
6
12.23
4.32
2.1
2.3
—
—
—
0
0
7
6
12.23
4.32
2.1
2.3
—
—
—
0
0
7
6
12.23
4.32
2.1
2.3
—
—
—
0
0
7
6
12.23
4.32
2.1
2.3
—
—
—
0
0
7
6
12.23
4.32
2.1
2.2
—
—
—
0
0
9
15
6.36
3.89
2.4
1.5
—
—
—
0
0
6
5
12.48
3.80
1.3
1.0
—
—
u/ml
—
0
0
10
26
4.08
3.59
3.7
1.8
—
—
—
0
0
79
571
1.98
3.47
3.3
2.9
14.9
15.0
pmol/l
0.05
68
513
7
10
7.32
3.41
1.3
1.3
—
—
—
0
0
59
391
1.93
3.31
4.0
2.4
0.0
0.0
estimate
0.00
14
67
59
393
1.92
3.24
5.8
3.2
0.0
0.0
estimate
0.00
14
64
19
81
2.58
3.16
6.4
2.1
—
—
—
0
0
59
396
1.90
3.15
4.1
2.4
0.0
0.0
estimate
0.00
14
67
6
8
7.79
3.09
2.0
2.6
—
—
—
0
0
7
12
6.09
3.06
2.3
1.7
—
—
—
0
0
5
5
10.32
3.00
1.4
1.8
—
—
—
0
0
25
128
2.18
2.79
1.2
1.1
1.3
0.6
u/ml
—
9
39
5
6
8.60
2.77
1.4
1.3
—
—
—
0
0
7
14
5.22
2.76
2.4
1.5
—
—
—
0
0
7
17
4.29
2.39
3.1
2.9
1.5
1.0
%
—
7
17
5
8
6.44
2.39
1.4
1.3
—
—
—
0
0
5
8
6.44
2.39
1.2
1.0
—
—
—
0
0
5
8
6.44
2.39
1.0
1.0
—
—
—
0
0
6
13
4.78
2.30
10.8
1.6
59.3
46.2
%
—
6
13
114
1000
2.14
2.17
52.5
9.8
138.9
140.0
mmol/l
4.18
114
960
114
1004
2.10
2.08
54.2
9.9
4.0
4.0
mmol/l
1.09
114
963
8
30
2.77
1.75
16.9
4.0
26.4
24.7
mmol/l
—
8
30
12
55
2.30
1.73
4.3
3.1
1.3
1.2
mmol/l
0.41
12
43
114
1021
1.95
1.72
30.7
7.1
24.3
24.5
u/l
0.09
114
964
114
1025
1.91
1.64
56.3
10.8
80.5
79.2
umol/l
0.18
114
1025
19
110
1.85
1.53
1.2
1.2
1.1
9.3
u/ml
—
6
41
20
118
1.82
1.52
1.3
1.2
26.4
39.9
iu/ml
—
5
37
103
909
1.64
1.47
40.7
8.5
79.3
78.4
ml/min/173m2
0.18
97
713
91
783
1.54
1.43
4.2
3.2
1.7
2.0
mu/l
1.50
81
693
12
63
2.00
1.27
5.7
2.5
35.8
70.3
ml/min/173m2
—
5
22
18
109
1.76
1.27
1.2
1.3
—
—
—
0
0
41
306
1.50
1.26
4.3
2.5
—
—
—
0
0
29
216
1.44
0.89
4.2
2.6
0.0
0.0
estimate
0.00
13
66
87
940
0.77
0.64
4.3
3.6
1.5
1.5
mmol/l
0.15
80
853
5
89
0.54
0.58
2.0
1.6
—
—
—
0
0
15
109
1.43
0.54
4.7
4.9
3.1
54.4
ug/l
0.71
15
90
114
1090
1.37
0.51
72.0
12.9
124.0
138.9
g/l
15.22
114
1057
89
945
0.82
0.45
4.2
3.6
4.6
4.9
mmol/l
1.53
82
854
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
91
959
0.83
0.39
4.6
4.0
2.6
3.0
mmol/l
2.26
84
870
55
498
1.18
0.37
5.1
5.0
1.7
4.3
ug/l
0.79
46
440
6
46
1.32
0.33
1.7
2.1
—
—
—
0
0
5
41
1.23
0.22
1.6
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
39
420
0.90
0.18
3.8
4.4
22.1
21.5
%
0.09
17
232
29
317
0.89
0.17
3.8
3.0
0.7
0.8
ug/l
0.20
21
226
11
93
1.20
0.15
1.5
1.4
—
—
—
0
0
87
845
1.09
0.14
5.4
3.5
40.8
36.9
mmol/mol
3.59
80
775
87
893
0.92
0.12
4.0
3.3
1.4
1.2
mmol/l
1.16
81
811
10
101
0.99
0.00
9.9
4.4
—
—
—
0
0
0
6
0.00
0.00
0.0
4.2
—
47.0
—
0
6
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint ABPA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ABPA | 3.293 [2.26, 4.8] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.603 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 184 females with ABPA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ABPA | 4.575 [3.14, 6.67] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 299 males with ABPA died.
Mortality risk
Mortality risk for people of age
years, who have ABPA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.361% | 0.785% |
| 5 | 2.115% | 5.488% |
| 10 | 5.29% | 13.321% |
| 15 | 10.035% | 24.056% |
| 20 | 16.778% | 38.985% |
Relationships between endpoints
↥Index endpoint: ABPA – Allergic bronchopulmonary aspergillosis (ABPA)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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