aspergillosis: Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma , a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess , is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
150 |
4. Check minimum number of eventsNone |
150 |
5. Include endpointsNone |
150 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
- Control exclude
- ASTHMA_COMORB
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- B44
- Name in latin
- Aspergillosis pulmonalis
Similar endpoints
↥List of similar endpoints to
Allergic bronchopulmonary aspergillosis (ABPA)
based on the number of shared cases.
Similar with more cases:
- Aspergillosis
- Mycoses
- Mycoses
- Certain infectious and parasitic diseases
- Certain infectious and parasitic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 699 | 250 | 439 |
| Only index persons | 549 | 205 | 344 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.91 | 66.25 | 65.77 |
| Only index persons | 65.36 | 65.64 | 65.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | 51 | 92 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 64.81 | 58.99 | 68.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 150
- Matched controls
- 1500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
+∞
189.5
139
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
42.5
118.3
86
46
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
55.0
95.7
58
17
J18.9
ICD-10 Finland
Pneumonia, unspecified
25.0
87.2
115
174
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
21.4
81.2
81
78
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
25.3
78.3
65
44
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
45.0
77.7
49
16
J01MA14
ATC
moxifloxacin; systemic
22.4
76.4
69
55
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
21.7
72.3
65
51
J02AC03
ATC
voriconazole; systemic
582.0
72.2
66
*
R03BB04
ATC
tiotropium bromide; inhalant
20.8
72.0
67
56
J45.1
ICD-10 Finland
Nonallergic asthma
32.7
66.0
46
20
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
24.3
64.7
52
32
GD1AA
NOMESCO Finland
Thorax X-ray examination
19.9
62.5
125
301
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
36.0
60.1
40
15
GD1AD
NOMESCO Finland
Thorax CT examination
23.9
60.0
48
29
H02AB06
ATC
prednisolone; systemic
20.3
59.1
128
334
J45.9
ICD-10 Finland
Asthma, unspecified
14.0
57.2
70
88
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
12.6
55.1
78
119
J45.0
ICD-10 Finland
Predominantly allergic asthma
18.7
54.8
50
39
R03AK06
ATC
salmeterol and fluticasone; inhalant
13.6
52.1
62
74
TGC00
NOMESCO Finland
Bronchial lavation
95.2
51.6
55
9
R04.2
ICD-10 Finland
Haemoptysis
25.1
50.0
38
20
J01MA12
ATC
levofloxacin; systemic
11.1
49.8
79
137
H25.1
ICD-10 Finland
Senile nuclear cataract
19.8
46.9
40
27
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
22.0
46.0
37
22
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
16.2
41.9
40
33
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
17.2
40.6
37
28
R03BA05
ATC
fluticasone; inhalant
9.5
40.2
65
112
A49.9
ICD-10 Finland
Bacterial infection, unspecified
12.7
38.2
43
46
R03DC03
ATC
montelukast; oral
9.7
37.5
56
87
R03DA04
ATC
theophylline; systemic, rectal
13.4
32.5
34
32
J47
ICD-10 Finland
Bronchiectasis
60.8
32.4
37
8
H02AB04
ATC
methylprednisolone; systemic
8.4
30.9
50
84
C03CA01
ATC
furosemide; systemic
7.5
30.5
58
116
R50.9
ICD-10 Finland
Fever, unspecified
8.0
29.5
50
88
R06.0
ICD-10 Finland
Dyspnoea
7.0
29.4
61
133
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
9.2
28.7
41
59
R03AC02
ATC
salbutamol; inhalant
7.1
28.0
112
440
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
+∞
28.0
26
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
7.1
27.8
113
450
H02AB07
ATC
prednisone; oral
9.4
27.7
38
52
I25.1
ICD-10 Finland
Atherosclerotic heart disease
170.7
27.7
28
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
6.0
27.2
82
250
XF400
NOMESCO Finland
ECG with 12 standard connections
8.4
26.7
41
64
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
9.4
26.3
36
49
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
7.4
25.5
45
82
J45
ICD-10 Finland
Asthma
10.2
25.4
32
39
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
8.1
24.9
39
62
M05BA04
ATC
alendronic acid; oral
11.6
24.9
28
29
ZX120
NOMESCO Finland
Intravenous
9.6
24.9
33
43
TPH04
NOMESCO Finland
Cathetrisation of vein
6.4
24.9
54
121
B44.9
ICD-10 Finland
Aspergillosis, unspecified
+∞
24.7
23
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
10.0
24.4
31
38
B44.0
ICD-10 Finland
Invasive pulmonary aspergillosis
283.4
24.4
24
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
283.4
24.4
24
*
R03AC12
ATC
salmeterol; inhalant
25.4
24.4
34
17
R03BA01
ATC
beclometasone; inhalant
6.8
23.7
46
92
103
Kela drug reimbursment
Diabetes, insulin-treated
+∞
23.6
22
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
6.4
23.3
49
106
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
10.8
22.8
27
30
B44.8
ICD-10 Finland
Other forms of aspergillosis
+∞
22.5
21
*
TPH07
NOMESCO Finland
Cathetrisation of artery
8.4
22.2
33
49
R03AK08
ATC
formoterol and beclometasone; inhalant
24.0
21.9
31
16
215
Kela drug reimbursment
Diabetes, non-insulin-treated
+∞
21.4
20
*
R03BA08
ATC
ciclesonide; inhalant
8.7
21.2
30
42
B01AA03
ATC
warfarin; systemic
9.3
21.2
28
36
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.3
21.0
58
159
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.2
20.9
36
63
R03BA02
ATC
budesonide; inhalant
5.9
20.4
46
105
ZXD05
NOMESCO Finland
Urgent procedure
5.2
20.3
58
163
J01FA06
ATC
roxithromycin; oral
4.8
20.1
89
352
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
229.0
20.1
20
*
XG410
NOMESCO Finland
Flow-volume spirometry
28.2
19.4
26
11
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
23.2
19.0
27
14
A02BC02
ATC
pantoprazole; systemic
5.5
19.0
117
587
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
29.7
18.9
25
10
J01FF01
ATC
clindamycin; systemic
4.7
18.2
60
187
WX892
NOMESCO Finland
Monitored bed care
20.3
18.2
27
16
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
18.1
17
*
J17.2*B44.1
ICD-10 Finland
Pneumonia in other aspergillosis
+∞
18.1
17
*
C07AB07
ATC
bisoprolol; oral
4.4
18.1
71
253
AA1AD
NOMESCO Finland
CT of head and brain
5.0
17.6
49
133
WX408
NOMESCO Finland
General anesthesy, balanced
4.6
17.6
59
186
Z96.1
ICD-10 Finland
Presence of intraocular lens
29.9
17.5
23
9
R02
ICPC
Shortness of breath/dyspnoea
7.6
17.3
27
42
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
17.0
16
*
207
Kela drug reimbursment
Chronic arrhythmias
190.3
16.9
17
*
GDC00
NOMESCO Finland
Lobectomy of lung
190.3
16.9
17
*
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
45.7
16.8
20
5
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
5.6
16.5
37
83
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
14.1
16.4
28
24
J46
ICD-10 Finland
Status asthmaticus
67.6
16.1
18
*
Z3231
NOMESCO Finland
Registered nurse
4.5
16.0
53
164
127
Kela drug reimbursment
Transplant complication
95.3
15.9
17
*
J01FA15
ATC
telithromycin; oral
6.3
15.9
30
57
R4110
NOMESCO Finland
Physiotherapy
4.4
15.9
55
176
R81
ICPC
Pneumonia
16.4
15.7
25
18
JN4BD
NOMESCO Finland
Extensive body CT
5.3
15.6
37
87
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
24.1
15.1
21
10
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.1
14.9
56
189
WX872
NOMESCO Finland
Intensive care
89.0
14.9
16
*
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
+∞
14.8
14
*
J01MA02
ATC
ciprofloxacin; systemic
3.8
14.8
76
318
R03AC13
ATC
formoterol; inhalant
12.9
14.7
26
24
JN4AD
NOMESCO Finland
Body CT examination
5.9
14.3
29
59
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
6.5
13.9
25
45
R03AK07
ATC
formoterol and budesonide; inhalant
4.3
13.8
44
131
ZXA10
NOMESCO Finland
Bilateral
5.8
13.7
28
57
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
23.9
13.7
19
9
A10AB05
ATC
insulin aspart; parenteral
153.3
13.7
14
*
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
14.1
13.7
23
19
C01DA14
ATC
isosorbide mononitrate; oral
25.3
13.2
18
8
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
16.1
13.2
21
15
WX002
NOMESCO Finland
Sedation and analgesia
4.5
13.2
39
109
ZXA05
NOMESCO Finland
Left side
4.0
13.2
48
157
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
6.8
13.0
22
37
Z2221
NOMESCO Finland
Medical doctor
4.0
13.0
49
164
A10BA02
ATC
metformin; oral
19.6
12.9
19
11
J45.8
ICD-10 Finland
Mixed asthma
22.5
12.8
18
9
ZXE00
NOMESCO Finland
One hour or less
3.6
12.6
63
254
Z3226
NOMESCO Finland
Physiotherapist
4.8
12.5
33
84
R03AC03
ATC
terbutaline; inhalant
5.0
12.1
29
68
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.1
12.0
40
122
49300
ICD-8 Finland
Asthma, bronchiale
21.1
11.9
17
9
WX100
NOMESCO Finland
Conjunctival surface anesthesia
25.4
11.8
16
7
H26.4
ICD-10 Finland
After-cataract
70.6
11.8
13
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.8
11.8
45
151
J02AC05
ATC
isavuconazole; systemic
+∞
11.6
11
*
J02AC04
ATC
posaconazole; systemic
129.5
11.6
12
*
H25.8
ICD-10 Finland
Other senile cataract
129.5
11.6
12
*
AN1
HP
Coronary angiography
129.5
11.6
12
*
A10AE04
ATC
insulin glargine; parenteral
129.5
11.6
12
*
J01AA02
ATC
doxycycline; systemic
5.1
11.6
131
865
WX302
NOMESCO Finland
Thoracal epidural anesthesy
9.9
11.5
23
27
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
38.3
11.5
14
*
A02BC01
ATC
omeprazole; systemic
3.6
11.4
51
190
J01FA09
ATC
clarithromycin; systemic
3.4
11.4
60
248
R06AE07
ATC
cetirizine; oral
3.2
11.3
71
325
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.8
11.2
43
144
L04AA06
ATC
mycophenolic acid; systemic
30.6
10.9
14
5
J01FA10
ATC
azithromycin; systemic
3.2
10.8
93
507
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
64.7
10.8
12
*
N03AX16
ATC
[U] pregabalin
3.7
10.8
43
148
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
117.9
10.6
11
*
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
35.3
10.5
13
*
A28
ICPC
Limited function/disability NOS
4.4
10.5
30
81
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
25.5
10.4
14
6
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
9.9
10.2
20
23
N02AA05
ATC
oxycodone; systemic
3.6
10.2
40
136
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.5
10.1
21
43
A10AC01
ATC
insulin (human); parenteral
43.2
10.1
12
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
18.3
10.1
15
9
WW200
NOMESCO Finland
Immunization
21.9
10.0
14
7
T90
ICPC
Diabetes non-insulin dependent
8.1
9.9
22
31
A07AA02
ATC
nystatin; oral
10.2
9.9
19
21
A02BC05
ATC
esomeprazole; systemic
3.0
9.8
64
296
J02AC01
ATC
fluconazole; systemic
3.1
9.7
57
248
XW000
NOMESCO Finland
Bone marrow biopsy
9.7
9.6
19
22
R03AK11
ATC
formoterol and fluticasone; inhalant
13.6
9.6
16
13
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
19.1
9.6
14
8
B01AB05
ATC
enoxaparin; parenteral
3.1
9.6
57
249
Z2446
NOMESCO Finland
Social worker
11.8
9.6
17
16
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
106.5
9.5
10
*
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
106.5
9.5
10
*
B01AC04
ATC
clopidogrel; oral
8.9
9.2
19
24
SPAT1262
SPAT
Handing over of treatment supplies
5.0
9.2
21
47
N02BE01
ATC
paracetamol; systemic, rectal
5.3
9.1
137
998
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.4
9.1
19
39
WZC30
NOMESCO Finland
Teaching
3.6
9.0
34
112
N02AX02
ATC
tramadol; systemic, rectal
2.8
8.9
70
353
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.8
8.9
20
29
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
12.7
8.8
15
13
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
53.2
8.8
10
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
53.2
8.8
10
*
I50.9
ICD-10 Finland
Heart failure, unspecified
8.7
8.7
18
23
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.4
8.6
18
37
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.1
8.6
47
194
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
95.2
8.5
9
*
J01CA04
ATC
amoxicillin; systemic
3.6
8.4
125
874
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.8
8.4
68
346
R01AD09
ATC
mometasone; nasal
2.8
8.4
69
354
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
+∞
8.4
8
*
J85.1
ICD-10 Finland
Abscess of lung with pneumonia
+∞
8.4
8
*
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
+∞
8.4
8
*
TFP20
NOMESCO Finland
Cardiodefibrillation
+∞
8.4
8
*
A10BH01
ATC
sitagliptin; oral
+∞
8.4
8
*
J85.2
ICD-10 Finland
Abscess of lung without pneumonia
+∞
8.4
8
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
+∞
8.4
8
*
E66.8
ICD-10 Finland
Other obesity
+∞
8.4
8
*
JN4CD
NOMESCO Finland
Very extensive body CT
7.0
8.4
20
32
R96
ICPC
Asthma
7.0
8.4
20
32
WW500
NOMESCO Finland
Blood transfusion
9.8
8.3
16
18
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
12.7
8.3
14
12
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
12.7
8.3
14
12
ZXE30
NOMESCO Finland
More than five and less than seven hours
12.7
8.3
14
12
A03
ICPC
Fever
3.7
8.2
30
96
J43.9
ICD-10 Finland
Emphysema, unspecified
18.5
8.2
12
7
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
18.5
8.2
12
7
R03DC01
ATC
zafirlukast; oral
18.5
8.2
12
7
L04AD01
ATC
ciclosporin; systemic
35.5
8.2
10
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
23.6
8.1
11
5
XG474
NOMESCO Finland
Exhalation nntrogen oxide
14.1
8.0
13
10
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
14.1
8.0
13
10
SPAT1255
SPAT
Intravenous administration of medicine
7.1
8.0
19
30
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
10.3
8.0
15
16
TDM10
NOMESCO Finland
Puncture of maxillary antrum
10.3
8.0
15
16
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
10.3
8.0
15
16
UJF32
NOMESCO Finland
Coloscopy
3.1
8.0
41
163
ZXA00
NOMESCO Finland
Right side
3.0
7.9
44
183
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
8.8
7.8
16
20
L04AD02
ATC
tacrolimus; systemic
47.5
7.8
9
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
47.5
7.8
9
*
A01AB04
ATC
amphotericin B; local oral
9.7
7.8
15
17
TPX10
NOMESCO Finland
Implantation of vascular injection port
9.7
7.8
15
17
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
4.4
7.7
21
54
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
26.6
7.7
10
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.5
7.5
17
25
R01AD01
ATC
beclometasone; nasal
3.5
7.5
29
96
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
14.4
7.5
12
9
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
84.1
7.5
8
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
84.1
7.5
8
*
H02AB09
ATC
hydrocortisone; systemic
10.2
7.5
14
15
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
11.7
7.5
13
12
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
11.7
7.5
13
12
R03BB01
ATC
ipratropium bromide; inhalant
8.0
7.4
16
22
G47.3
ICD-10 Finland
Sleep apnoea
3.3
7.4
32
114
J02AC02
ATC
itraconazole; systemic
3.2
7.4
35
132
WX725
NOMESCO Finland
Noninvasive ventilation
7.2
7.4
17
26
J17.2*B44.0
ICD-10 Finland
Pneumonia in invasive aspergillosis
+∞
7.3
7
*
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
+∞
7.3
7
*
R01AD08
ATC
fluticasone; nasal
2.8
7.3
48
217
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
8.6
7.3
15
19
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
8.6
7.3
15
19
D64.9
ICD-10 Finland
Anaemia, unspecified
4.6
7.2
18
43
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
31.7
7.2
9
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
3.7
7.2
25
77
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
7.0
7.2
17
27
M04AA01
ATC
allopurinol; systemic
3.9
7.2
23
67
A02BC03
ATC
lansoprazole; oral
2.8
7.0
45
201
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.0
6.9
21
59
A10BB12
ATC
glimepiride; oral
42.0
6.8
8
*
J01DB01
ATC
cefalexin; oral
3.0
6.8
121
875
R07.4
ICD-10 Finland
Chest pain, unspecified
3.1
6.8
33
126
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
13.1
6.7
11
9
L03AA02
ATC
filgrastim; parenteral
6.8
6.7
16
26
J33.0
ICD-10 Finland
Polyp of nasal cavity
8.0
6.6
14
19
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
8.0
6.6
14
19
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
7.1
6.5
15
23
J96.1
ICD-10 Finland
Chronic respiratory failure
15.2
6.5
10
7
P01BA02
ATC
hydroxychloroquine; oral
8.8
6.5
13
16
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
72.8
6.5
7
*
A10BK01
ATC
dapagliflozin; oral
72.8
6.5
7
*
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
72.8
6.5
7
*
J96.0
ICD-10 Finland
Acute respiratory failure
72.8
6.5
7
*
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
72.8
6.5
7
*
S18
ICPC
Laceration/cut
2.4
6.4
73
425
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
19.0
6.3
9
5
ZXE20
NOMESCO Finland
More than three and less than five hours
3.4
6.3
25
84
L88
ICPC
Rheumatoid/seropositive arthritis
28.0
6.3
8
*
J98.1
ICD-10 Finland
Pulmonary collapse
+∞
6.3
6
*
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
+∞
6.3
6
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
6.3
6
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
6.3
6
*
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
+∞
6.3
6
*
J01GB01
ATC
tobramycin; inhalant, parenteral
+∞
6.3
6
*
Z94.2
ICD-10 Finland
Lung transplant status
+∞
6.3
6
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
6.5
6.2
15
25
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
6.5
6.2
15
25
B02AA02
ATC
tranexamic acid; systemic
3.7
6.1
21
64
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
7.8
6.1
13
18
B01AF02
ATC
apixaban; oral
7.8
6.1
13
18
J01DA01
ATC
[U] cefalexin
2.4
6.0
92
604
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
77
27
57.54
122.68
7.1
3.0
—
—
—
0
0
49
20
35.90
72.22
2.8
1.0
—
—
—
0
0
79
108
14.34
61.26
4.2
1.6
—
—
—
0
0
65
72
15.17
57.96
3.4
1.4
—
—
—
0
0
64
75
14.14
54.70
3.6
1.4
—
—
—
0
0
51
54
13.79
46.08
9.8
4.8
2.00
1.07
mmol/l
0.70
42
45
35
31
14.42
34.88
2.5
1.8
—
—
—
0
0
39
11
47.25
32.54
7.0
2.7
—
—
—
0
0
36
7
66.96
32.02
2.3
1.4
—
—
—
0
0
108
388
7.37
30.67
15.7
4.7
1.20
1.22
mmol/l
2.73
98
326
34
6
72.52
30.62
2.7
1.0
—
—
—
0
0
38
16
31.30
28.78
3.7
1.4
—
—
—
0
0
37
15
32.23
28.27
3.6
1.4
—
—
—
0
0
62
145
6.58
27.59
2.3
1.5
3.42
2.47
mg/l
2.03
54
121
30
5
74.27
27.13
1.8
1.6
—
—
—
0
0
98
350
6.19
27.09
16.3
4.1
1.26
1.12
inr
0.76
28
82
28
5
68.20
25.02
1.8
1.6
—
—
—
0
0
81
278
5.16
22.53
2.6
1.7
79.69
79.94
nmol/l
0.02
74
236
31
15
25.65
22.38
1.4
1.1
—
—
—
0
0
29
11
32.30
22.35
3.4
1.3
—
—
—
0
0
29
13
27.27
21.37
4.2
1.5
—
—
—
0
0
29
13
27.27
21.37
4.2
1.5
—
—
—
0
0
25
30
9.80
19.86
1.5
1.2
—
—
—
0
0
51
133
5.29
19.40
3.8
2.0
517.98
71.61
ng/l
1.17
45
92
26
40
7.65
16.80
2.6
1.5
—
—
—
0
0
34
73
5.73
15.86
16.9
4.9
102.32
104.64
mmol/l
1.99
34
73
68
254
4.07
15.84
8.3
3.4
28.06
58.26
u/l
0.64
68
247
23
13
20.62
15.73
1.8
1.3
—
—
—
0
0
65
240
4.01
15.30
5.1
2.5
0.70
0.39
e6/l
0.27
55
173
77
324
3.83
14.89
4.9
2.6
—
—
—
0
0
19
7
30.76
14.68
3.2
1.1
—
—
—
0
0
20
9
25.38
14.66
2.8
1.1
—
—
—
0
0
13
0
+∞
13.75
6.7
0.0
—
—
—
0
0
19
9
23.90
13.73
3.9
1.4
—
—
—
0
0
19
9
23.90
13.73
3.9
1.4
—
—
—
0
0
18
7
28.91
13.73
4.2
1.6
—
—
—
0
0
18
7
28.91
13.73
4.2
1.6
—
—
—
0
0
50
164
4.07
13.72
2.6
1.4
1.71
0.92
mg/l
0.63
45
125
21
14
17.20
13.57
1.9
2.5
—
—
—
0
0
72
309
3.56
13.17
2.2
1.5
97.05
101.76
pmol/l
0.39
47
159
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
19
13.35
12.81
3.0
2.7
0.22
0.28
u/ml
—
9
9
12
0
+∞
12.68
1.8
0.0
—
—
—
0
0
68
292
3.43
12.25
4.4
1.8
33.79
15.24
ng/l
0.95
56
176
22
22
11.51
11.98
12.4
3.5
25.60
25.70
mmol/l
0.03
22
22
11
0
+∞
11.60
1.8
0.0
—
—
—
0
0
11
0
+∞
11.60
1.8
0.0
—
—
—
0
0
17
10
18.96
11.50
4.8
2.0
25.74
24.93
mmol/l
—
17
10
14
5
30.61
10.94
3.6
1.4
—
—
—
0
0
14
5
30.61
10.94
3.6
1.4
—
—
—
0
0
14
5
30.61
10.94
3.6
1.4
—
—
—
0
0
41
136
3.77
10.84
5.0
2.5
0.34
1.20
e6/l
0.65
29
74
18
15
13.45
10.67
1.8
1.2
—
—
—
0
0
18
15
13.45
10.67
1.8
1.2
—
—
—
0
0
19
20
10.70
10.11
1.6
1.5
118.91
144.09
g/l
1.71
11
11
40
142
3.48
9.46
5.0
2.3
0.63
0.67
e6/l
0.05
28
78
16
15
11.78
9.04
6.1
2.7
368.56
149.24
ug/l
0.48
16
15
81
442
2.81
8.88
5.3
2.3
—
—
—
0
0
18
22
9.14
8.88
2.2
2.7
—
—
—
0
0
51
220
3.00
8.65
5.4
2.1
—
—
—
0
0
49
214
2.92
8.06
6.9
2.1
342.52
12363.25
umol/l
1.91
42
191
36
132
3.27
7.99
1.6
1.5
1030.43
1123.29
nmol/l
0.26
27
94
11
7
16.81
7.35
1.5
1.0
—
—
u/ml
—
0
0
7
0
+∞
7.35
1.6
0.0
—
—
—
0
0
17
27
6.96
7.18
17.2
5.7
0.70
0.68
%
0.08
17
27
90
558
2.53
7.09
3.7
2.3
—
—
—
0
0
17
28
6.71
7.01
17.2
5.6
1.16
1.06
%
0.25
17
28
134
1025
3.88
6.87
61.2
8.5
36.66
27.72
mg/l
2.10
129
707
35
143
2.89
6.37
1.6
1.5
434.87
77119065.92
pmol/l
0.50
30
118
16
28
6.26
6.35
17.8
5.6
94.44
94.75
%
0.07
16
28
6
0
+∞
6.29
1.5
0.0
—
—
—
0
0
11
11
10.68
6.14
1.3
1.4
—
—
—
0
0
11
12
9.78
5.89
1.5
1.8
—
—
—
0
0
74
446
2.30
5.87
6.6
3.2
0.00
0.00
estimate
-0.00
19
77
74
451
2.26
5.67
4.6
2.4
0.00
0.00
estimate
-0.00
19
85
74
452
2.26
5.63
4.6
2.4
0.00
0.00
estimate
-0.00
19
80
5
0
+∞
5.23
2.8
0.0
—
—
—
0
0
25
95
2.96
5.13
5.4
2.2
—
—
—
0
0
30
127
2.70
5.05
1.2
1.1
1.22
0.59
u/ml
1.06
11
37
95
666
2.16
4.86
3.3
2.8
14.93
14.93
pmol/l
0.00
84
593
37
177
2.45
4.86
4.2
1.9
16.90
10.07
mg/mmol
0.28
27
100
11
18
6.50
4.70
2.8
2.1
0.00
0.00
g/l
-0.00
11
18
11
18
6.50
4.70
2.8
2.1
0.00
0.00
g/l
-0.00
11
18
11
18
6.50
4.70
2.2
1.4
—
—
—
0
0
7
5
14.58
4.62
2.1
2.6
—
—
—
0
0
7
5
14.58
4.62
2.1
2.6
—
—
—
0
0
7
5
14.58
4.62
2.1
2.6
—
—
—
0
0
7
5
14.58
4.62
2.1
2.6
—
—
—
0
0
7
5
14.58
4.62
2.1
2.4
—
—
—
0
0
7
5
14.58
4.62
2.1
2.6
—
—
—
0
0
11
20
5.84
4.38
2.8
2.6
0.09
0.00
g/l
0.47
11
20
7
6
12.15
4.32
1.6
1.7
—
—
—
0
0
13
30
4.64
4.24
6.1
2.0
—
—
—
0
0
7
7
10.41
4.05
1.9
3.3
—
—
—
0
0
8
11
7.61
3.91
1.0
1.7
11.39
17.15
ug/l
—
8
11
17
62
2.96
3.73
4.4
3.1
1.24
1.23
mmol/l
0.21
17
49
8
12
6.97
3.72
2.1
1.7
—
—
—
0
0
8
12
6.97
3.72
1.3
1.2
—
—
—
0
0
11
26
4.48
3.58
3.5
1.7
—
—
—
0
0
26
123
2.35
3.45
1.3
1.1
22.00
37.54
iu/ml
—
7
40
8
14
5.97
3.39
2.3
1.5
—
—
—
0
0
24
114
2.32
3.15
1.2
1.1
1.01
8.85
u/ml
—
10
38
6
8
7.75
3.08
1.3
1.3
—
—
—
0
0
134
1167
2.39
2.85
53.9
9.0
138.68
140.03
mmol/l
6.53
134
1118
17
72
2.54
2.84
6.6
2.5
47.10
71.90
ml/min/173m2
—
10
29
9
23
4.09
2.82
15.8
4.0
26.78
24.67
mmol/l
—
9
23
134
1172
2.34
2.73
55.5
9.1
4.04
3.98
mmol/l
2.01
134
1123
6
10
6.20
2.72
1.0
1.0
—
—
—
0
0
6
11
5.63
2.57
1.2
1.0
—
—
—
0
0
5
7
7.34
2.57
1.4
1.3
—
—
—
0
0
5
7
7.34
2.57
1.2
1.0
114.60
98.57
%
—
5
7
52
355
1.71
2.40
4.4
2.5
—
—
—
0
0
7
17
4.26
2.39
10.0
1.8
55.47
46.92
%
—
7
17
134
1188
2.20
2.37
31.5
6.9
24.36
24.63
u/l
0.11
134
1120
122
1052
1.86
2.28
41.7
8.3
78.75
79.11
ml/min/173m2
0.07
115
825
134
1195
2.14
2.22
56.9
10.3
81.14
78.38
umol/l
0.52
134
1195
108
903
1.70
2.21
4.2
3.2
1.82
2.03
mu/l
1.20
97
796
5
14
3.66
1.63
1.6
1.4
—
—
—
0
0
36
253
1.56
1.42
4.9
2.7
0.00
0.00
estimate
-0.00
18
79
134
1262
1.58
0.93
73.6
12.3
37.97
40.94
%
8.31
124
1148
134
1263
1.57
0.91
72.6
12.3
280.37
241.37
e9/l
3.94
134
1204
19
129
1.54
0.88
1.3
1.3
—
—
—
0
0
134
1266
1.55
0.86
72.5
12.4
123.56
139.17
g/l
20.20
134
1223
5
96
0.50
0.81
2.0
1.7
—
—
—
0
0
0
20
0.00
0.61
0.0
1.2
—
—
—
0
0
67
593
1.23
0.59
4.7
5.3
1.66
4.21
ug/l
0.99
57
526
102
1090
0.80
0.58
4.4
3.6
1.48
1.51
mmol/l
0.22
94
989
104
1100
0.82
0.47
4.3
3.6
4.58
4.93
mmol/l
2.49
96
996
31
259
1.25
0.45
1.9
1.4
1.37
1.27
mmol/l
0.37
26
221
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
106
1114
0.83
0.41
4.7
4.0
2.62
3.02
mmol/l
3.54
98
1007
113
1075
1.21
0.41
4.7
3.5
6.07
5.60
mmol/l
1.86
108
961
6
45
1.35
0.34
2.5
1.4
43.17
4.48
mg/l
—
6
35
14
110
1.30
0.33
1.4
1.5
—
—
—
0
0
102
983
1.12
0.22
5.4
3.3
40.91
36.77
mmol/mol
4.09
94
892
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
38.12
—
0
5
0
12
0.00
0.21
0.0
1.0
—
535.40
—
0
5
6
51
1.18
0.19
1.7
1.9
—
—
—
0
0
102
1042
0.93
0.11
4.0
3.3
1.33
1.22
mmol/l
0.84
96
941
5
48
1.04
0.09
1.6
1.7
—
—
—
0
0
36
378
0.94
0.08
3.4
3.0
0.65
0.75
ug/l
0.56
25
262
49
504
0.96
0.05
3.6
4.6
23.23
20.15
%
0.62
21
272
11
118
0.93
0.03
9.1
4.3
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
49.86
—
0
7
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint ABPA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ABPA | 3.293 [2.26, 4.8] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.603 |
During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 184 females with ABPA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ABPA | 4.575 [3.14, 6.67] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 299 males with ABPA died.
Mortality risk
Mortality risk for people of age
years, who have ABPA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.361% | 0.785% |
| 5 | 2.115% | 5.488% |
| 10 | 5.29% | 13.321% |
| 15 | 10.035% | 24.056% |
| 20 | 16.778% | 38.985% |
Relationships between endpoints
↥Index endpoint: ABPA – Allergic bronchopulmonary aspergillosis (ABPA)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data