No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
272 |
4. Check minimum number of eventsNone |
272 |
5. Include endpointsNone |
272 |
6. Filter based on genotype QC (FinnGen only) |
272 |
Control definitions (FinnGen only)
- Control exclude
- AB1_MYCOSES
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Aspergillosis
based on the number of shared cases.
Similar with more cases:
- Mycoses
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1897 | 694 | 1166 |
| Only index persons | 1320 | 508 | 812 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 62.18 | 61.22 | 62.71 |
| Only index persons | 62.61 | 60.94 | 63.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 272 | 100 | 172 |
| Unadjusted period prevalence (%) | 0.06 | 0.03 | 0.08 |
| Median age at first event (years) | 62.48 | 58.19 | 64.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 243
- Matched controls
- 2431
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
+∞
126.4
110
*
J02AC03
ATC
voriconazole; systemic
1515.4
104.3
94
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
28.2
67.0
94
53
B44.0
ICD-10 Finland
Invasive pulmonary aspergillosis
+∞
66.8
61
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
18.2
61.8
103
94
J18.9
ICD-10 Finland
Pneumonia, unspecified
9.6
55.9
153
365
B44.9
ICD-10 Finland
Aspergillosis, unspecified
+∞
55.4
51
*
TGC00
NOMESCO Finland
Bronchial lavation
40.5
54.3
68
23
B44.8
ICD-10 Finland
Other forms of aspergillosis
+∞
50.8
47
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
12.3
49.0
98
126
J01MA14
ATC
moxifloxacin; systemic
12.8
47.1
91
108
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
33.5
46.6
61
24
R03BB04
ATC
tiotropium bromide; inhalant
11.3
46.0
96
132
J47
ICD-10 Finland
Bronchiectasis
80.5
41.8
46
7
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
14.4
40.4
72
69
J01MA12
ATC
levofloxacin; systemic
7.1
39.3
120
293
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.6
39.2
182
760
H02AB06
ATC
prednisolone; systemic
6.5
38.5
184
787
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
6.7
35.6
111
271
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
21.7
35.1
52
30
J45.0
ICD-10 Finland
Predominantly allergic asthma
11.5
34.8
69
81
GD1AD
NOMESCO Finland
Thorax CT examination
17.1
31.6
51
37
J45.9
ICD-10 Finland
Asthma, unspecified
6.6
31.4
95
216
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
8.6
30.7
73
116
R03AK06
ATC
salmeterol and fluticasone; inhalant
6.8
30.0
86
180
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.1
29.0
92
219
J45.1
ICD-10 Finland
Nonallergic asthma
12.0
27.5
52
54
R03DC03
ATC
montelukast; oral
6.4
27.0
80
172
H02AB04
ATC
methylprednisolone; systemic
6.6
26.9
78
163
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
12.5
23.5
43
41
R03AK08
ATC
formoterol and beclometasone; inhalant
13.1
23.0
41
37
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.1
22.9
50
67
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
4.0
22.8
161
802
R04.2
ICD-10 Finland
Haemoptysis
11.2
22.8
44
47
XG410
NOMESCO Finland
Flow-volume spirometry
11.1
21.7
42
45
R03AC12
ATC
salmeterol; inhalant
11.1
21.7
42
45
127
Kela drug reimbursment
Transplant complication
24.2
21.4
30
14
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
+∞
21.1
20
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.8
20.7
50
78
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
17.4
20.4
32
21
L03AA02
ATC
filgrastim; parenteral
15.7
20.2
33
24
H62.2*B44.8
ICD-10 Finland
Otitis externa in aspergillosis
+∞
20.1
19
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.1
19.5
69
176
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
8.3
19.2
44
63
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.3
19.2
44
63
R03AC02
ATC
salbutamol; inhalant
3.5
19.2
158
841
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
76.1
19.0
21
*
JN4BD
NOMESCO Finland
Extensive body CT
5.4
18.8
62
146
J01FA06
ATC
roxithromycin; oral
3.4
18.4
131
618
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
8.8
18.3
40
53
R03BA05
ATC
fluticasone; inhalant
4.4
18.1
75
223
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.3
17.8
59
139
J02AC04
ATC
posaconazole; systemic
182.0
16.7
17
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.4
16.7
68
198
R03BA01
ATC
beclometasone; inhalant
4.6
16.4
63
172
R03DA04
ATC
theophylline; systemic, rectal
6.9
16.4
42
71
R03AC13
ATC
formoterol; inhalant
9.2
16.2
34
42
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.3
16.1
110
488
R50.9
ICD-10 Finland
Fever, unspecified
4.4
16.1
65
187
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
6.9
16.0
41
69
GDC00
NOMESCO Finland
Lobectomy of lung
64.5
16.0
18
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
4.9
15.8
56
141
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
6.1
15.5
44
85
49300
ICD-8 Finland
Asthma, bronchiale
20.0
15.0
22
12
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.8
14.8
73
249
J45.8
ICD-10 Finland
Mixed asthma
12.0
14.4
26
24
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
14.2
79
295
A02BC02
ATC
pantoprazole; systemic
3.1
14.2
181
1182
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.6
14.2
37
64
XW000
NOMESCO Finland
Bone marrow biopsy
7.6
14.0
33
49
H02AB07
ATC
prednisone; oral
4.1
14.0
60
180
TDM10
NOMESCO Finland
Puncture of maxillary antrum
9.7
13.9
28
32
H02AB09
ATC
hydrocortisone; systemic
16.0
13.9
22
15
R81
ICPC
Pneumonia
12.5
13.6
24
21
L04AA06
ATC
mycophenolic acid; systemic
19.7
13.6
20
11
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
147.9
13.6
14
*
WW500
NOMESCO Finland
Blood transfusion
9.4
13.2
27
32
J01FA15
ATC
telithromycin; oral
4.9
13.1
45
108
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
53.0
13.0
15
*
A07AA02
ATC
nystatin; oral
6.5
13.0
34
59
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.8
12.8
44
106
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
34.1
12.7
16
5
J01FF01
ATC
clindamycin; systemic
3.0
12.7
96
438
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
15.4
12.5
20
14
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
12.5
95
434
J05AB11
ATC
valaciclovir; oral
4.2
12.5
51
146
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
11.9
93
432
J45
ICD-10 Finland
Asthma
4.7
11.9
42
104
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.4
11.8
63
224
R06.0
ICD-10 Finland
Dyspnoea
3.0
11.8
82
351
J01AA02
ATC
doxycycline; systemic
3.2
11.6
205
1529
R03AK07
ATC
formoterol and budesonide; inhalant
3.4
11.6
64
234
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
9.1
11.6
24
29
J02AC05
ATC
isavuconazole; systemic
+∞
11.5
11
*
J17.2*B44.0
ICD-10 Finland
Pneumonia in invasive aspergillosis
+∞
11.5
11
*
L04AD01
ATC
ciclosporin; systemic
11.4
11.5
21
20
J01FA10
ATC
azithromycin; systemic
2.6
11.4
151
942
J02AC02
ATC
itraconazole; systemic
3.4
11.4
62
224
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
37.0
11.4
14
*
J01FA09
ATC
clarithromycin; systemic
2.8
11.4
96
464
A05AA02
ATC
ursodeoxycholic acid; oral
14.8
11.2
18
13
R01AD09
ATC
mometasone; nasal
2.6
11.1
116
633
A04AA01
ATC
ondansetron; systemic, rectal
5.2
10.8
34
74
J02AC01
ATC
fluconazole; systemic
2.7
10.7
95
470
R03BA02
ATC
budesonide; inhalant
3.2
10.7
63
240
R03AK11
ATC
formoterol and fluticasone; inhalant
10.8
10.7
20
20
R03BA08
ATC
ciclesonide; inhalant
4.8
10.7
36
85
N02AA05
ATC
oxycodone; systemic
3.4
10.6
57
202
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
114.8
10.5
11
*
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
6.2
10.5
28
50
ZX120
NOMESCO Finland
Intravenous
4.3
10.5
40
107
JN4CD
NOMESCO Finland
Very extensive body CT
6.6
10.3
26
43
WX892
NOMESCO Finland
Monitored bed care
4.6
10.3
36
88
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.7
10.2
35
84
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.9
10.1
69
290
J46
ICD-10 Finland
Status asthmaticus
9.4
10.0
20
23
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
9.8
68
289
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
9.7
61
242
WW200
NOMESCO Finland
Immunization
8.1
9.6
21
28
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
18.5
9.5
14
8
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.6
9.5
86
423
UDM02
NOMESCO Finland
Sinoscopy
13.1
9.5
16
13
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
31.4
9.5
12
*
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
10.1
9.4
18
19
J17.2*B44.1
ICD-10 Finland
Pneumonia in other aspergillosis
+∞
9.4
9
*
B44.7
ICD-10 Finland
Disseminated aspergillosis
+∞
9.4
9
*
XG474
NOMESCO Finland
Exhalation nntrogen oxide
8.3
9.3
20
26
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
8.0
9.1
20
27
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
5.1
9.1
28
60
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
5.3
9.0
27
56
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
5.6
8.8
25
49
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
51.9
8.7
10
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
6.9
8.7
21
33
C03CA01
ATC
furosemide; systemic
2.5
8.7
87
449
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
7.8
8.6
19
26
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
28.7
8.6
11
*
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
93.2
8.5
9
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.7
8.5
63
276
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
11.3
8.4
15
14
R01AD08
ATC
fluticasone; nasal
2.5
8.4
76
371
Z94.2
ICD-10 Finland
Lung transplant status
+∞
8.4
8
*
J01DA01
ATC
[U] cefalexin; systemic
2.2
8.3
159
1111
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
9.4
8.2
16
18
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.8
8.0
26
59
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.5
8.0
38
123
R01AD12
ATC
fluticasone furoate; nasal
2.5
7.9
74
367
TPH07
NOMESCO Finland
Cathetrisation of artery
3.3
7.9
40
136
J01DB01
ATC
cefalexin; oral
2.5
7.9
200
1576
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.2
7.8
29
76
J01MA02
ATC
ciprofloxacin; systemic
2.2
7.8
112
683
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
46.5
7.8
9
*
R03AC03
ATC
terbutaline; inhalant
3.2
7.7
42
148
J01CA04
ATC
amoxicillin; systemic
2.4
7.7
196
1535
N03AX16
ATC
pregabalin; oral
2.5
7.6
70
344
M05BA04
ATC
alendronic acid; oral
3.8
7.5
31
89
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
13.9
7.5
12
9
D72.1
ICD-10 Finland
Eosinophilia
82.5
7.5
8
*
R03DC01
ATC
zafirlukast; oral
11.4
7.4
13
12
R03BB01
ATC
ipratropium bromide; inhalant
5.2
7.4
22
46
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.4
7.4
26
65
J96.1
ICD-10 Finland
Chronic respiratory failure
6.9
7.3
17
26
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
31.0
7.2
9
*
J98.1
ICD-10 Finland
Pulmonary collapse
20.8
7.2
10
5
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
20.8
7.2
10
5
AA1AD
NOMESCO Finland
CT of head and brain
2.4
7.2
69
344
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
4.6
7.2
24
57
R4110
NOMESCO Finland
Physiotherapy
2.3
7.1
78
414
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
7.0
53
234
J96.0
ICD-10 Finland
Acute respiratory failure
14.3
7.0
11
8
L03AA13
ATC
pegfilgrastim; parenteral
5.6
6.9
19
36
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
5.6
6.9
19
36
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
11.4
6.9
12
11
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
11.4
6.9
12
11
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
41.2
6.8
8
*
M04AA01
ATC
allopurinol; systemic
2.7
6.7
46
191
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
12.7
6.6
11
9
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
6.6
37
134
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
6.6
66
335
RS220
NOMESCO Finland
NA
10.4
6.6
12
12
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.0
6.6
17
30
SPAT1255
SPAT
Intravenous administration of medicine
4.0
6.5
25
68
A02BC01
ATC
omeprazole; systemic
2.2
6.5
76
413
6BA02
NOMESCO Finland
NA
71.7
6.5
7
*
ZX108
NOMESCO Finland
Inhalation
14.8
6.5
10
7
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.6
6.4
21
49
Y84.8
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
18.6
6.3
9
5
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
+∞
6.3
6
*
2AX04
NOMESCO Finland
NA
+∞
6.3
6
*
NH4AE
NOMESCO Finland
Achilles tendon ultrasound examination
+∞
6.3
6
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
6.3
6
*
J01GB01
ATC
tobramycin; inhalant, parenteral
+∞
6.3
6
*
WW306
NOMESCO Finland
Transfer of stem cells from foreign registered donator
+∞
6.3
6
*
ZX121
NOMESCO Finland
Central venous catheter
+∞
6.3
6
*
2AA01
NOMESCO Finland
NA
+∞
6.3
6
*
GDB10
NOMESCO Finland
Wedge resection of lung
27.5
6.3
8
*
A41.9
ICD-10 Finland
Sepsis, unspecified
4.9
6.3
19
41
J43.9
ICD-10 Finland
Emphysema, unspecified
8.9
6.1
12
14
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
5.8
6.1
16
29
ZX112
NOMESCO Finland
Subcutaneous
6.3
6.1
15
25
A03FA01
ATC
metoclopramide; systemic, rectal
2.4
6.0
56
273
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
17
73.52
154.67
3.9
1.3
9.7
0.1
u/ml
5.63
75
12
113
85
22.03
128.39
6.2
2.9
—
—
—
0
0
101
124
12.37
82.29
4.9
1.2
1389.9
212.8
u/ml
2.42
96
113
54
28
23.82
71.20
2.4
1.7
—
—
—
0
0
53
29
22.46
68.19
6.7
4.2
—
—
—
0
0
65
60
13.92
63.26
2.8
1.5
—
—
—
0
0
39
13
34.85
59.97
1.9
1.2
—
—
—
0
0
58
62
11.62
50.79
4.6
1.7
—
—
—
0
0
51
46
13.41
49.91
20.3
7.7
261.1
114.7
iu/ml
—
17
8
56
63
10.93
47.17
4.5
1.7
—
—
—
0
0
48
43
13.34
47.09
4.6
1.7
—
—
—
0
0
52
54
11.67
46.30
2.3
1.6
—
—
—
0
0
44
44
11.74
39.99
2.4
1.6
—
—
—
0
0
119
361
5.08
37.75
4.6
1.9
—
—
—
0
0
35
28
14.20
36.48
5.5
2.0
—
—
—
0
0
116
357
4.92
35.88
12.3
3.4
0.8
0.8
mmol/l
1.52
110
334
42
46
10.62
35.72
2.3
1.6
—
—
—
0
0
35
30
13.24
34.97
5.5
1.9
—
—
—
0
0
31
22
15.77
34.48
2.7
2.2
556.7
540.9
e6/l
—
23
8
38
40
10.88
33.17
1.8
1.6
—
—
—
0
0
40
47
9.81
32.22
1.8
1.6
—
—
—
0
0
34
32
12.00
31.96
1.4
1.1
—
—
—
0
0
26
16
17.86
31.00
2.3
2.2
10.4
16.2
%
—
10
9
24
16
16.35
27.41
2.0
2.2
—
—
—
0
0
21
11
20.60
26.82
7.3
2.0
—
—
—
0
0
21
11
20.60
26.82
7.3
2.0
—
—
—
0
0
21
11
20.60
26.82
7.3
2.0
—
—
—
0
0
21
11
20.60
26.82
7.3
2.0
—
—
—
0
0
86
256
4.45
26.82
3.2
1.9
—
—
—
0
0
20
10
21.51
26.02
6.8
2.0
—
—
—
0
0
20
10
21.51
26.02
6.8
2.0
—
—
—
0
0
20
10
21.51
26.02
6.7
2.0
—
—
—
0
0
84
257
4.28
25.09
3.4
2.0
—
—
—
0
0
27
28
10.60
23.61
2.9
1.5
—
—
—
0
0
30
36
9.24
23.59
3.0
1.5
—
—
—
0
0
50
108
5.45
22.78
1.7
2.5
1.9
1.5
g/l
1.37
39
96
18
10
19.20
22.28
5.3
6.1
—
—
—
0
0
20
14
15.34
22.14
2.1
1.2
—
—
—
0
0
59
153
4.65
21.62
3.0
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
39
70
6.34
21.54
4.2
2.4
0.3
0.3
u/ml
1.01
27
34
24
25
10.43
20.86
6.7
2.0
—
—
—
0
0
24
25
10.43
20.86
6.8
2.0
—
—
—
0
0
24
25
10.43
20.86
6.8
2.0
—
—
—
0
0
83
288
3.71
20.31
13.7
6.2
1.0
1.0
mmol/l
0.00
78
269
36
64
6.33
20.03
2.0
1.4
—
—
—
0
0
43
93
5.30
19.45
2.9
2.3
0.9
3.8
ug/l
0.50
43
86
176
993
3.19
18.74
10.8
5.9
1.2
1.2
mmol/l
0.25
171
900
24
8
32.71
18.68
3.2
1.5
—
—
—
0
0
19
17
11.94
18.18
1.9
1.5
—
—
—
0
0
182
1090
3.02
16.62
15.7
6.9
1.2
1.2
mmol/l
0.75
165
923
17
16
11.27
15.69
3.1
2.0
—
—
—
0
0
25
43
6.30
14.27
1.8
1.5
—
—
—
0
0
25
43
6.30
14.27
1.8
1.5
—
—
—
0
0
69
261
3.20
14.26
6.3
6.6
1.9
0.9
mmol/l
1.06
57
206
161
956
2.68
14.04
11.1
4.9
32.4
35.3
g/l
7.00
156
895
30
65
5.06
13.42
1.9
1.8
—
—
—
0
0
25
46
5.88
13.33
1.6
1.2
—
—
—
0
0
16
18
9.38
13.01
1.3
1.2
—
—
—
0
0
43
131
3.71
12.38
1.6
1.5
—
—
—
0
0
55
198
3.23
12.22
5.7
4.1
2.5
2.0
mmol/l
0.30
47
152
106
545
2.55
12.03
2.7
2.0
3.4
3.1
mg/l
0.58
91
470
25
52
5.19
11.68
1.6
2.5
118.2
127.1
g/l
0.65
12
36
28
66
4.61
11.31
2.0
1.2
—
—
—
0
0
42
143
3.29
10.14
8.6
3.7
2.1
1.7
mmol/l
0.49
37
107
124
732
2.28
9.89
6.7
3.3
2.3
2.3
mmol/l
1.85
113
638
30
84
3.89
9.69
8.0
1.9
—
—
—
0
0
216
1620
2.62
9.66
11.4
4.1
24.3
12.5
mm/h
8.90
206
1483
122
725
2.24
9.48
8.1
3.8
30.9
32.8
u/l
0.25
122
684
72
347
2.46
9.03
5.7
3.1
0.6
1.8
e6/l
2.11
54
200
130
810
2.16
8.80
5.7
3.2
—
—
—
0
0
15
25
6.29
8.75
2.9
1.5
—
—
—
0
0
15
25
6.29
8.75
2.9
1.5
—
—
—
0
0
15
25
6.29
8.75
2.9
1.5
—
—
—
0
0
15
25
6.29
8.75
2.9
1.5
—
—
—
0
0
15
25
6.29
8.75
2.9
1.5
—
—
—
0
0
27
76
3.83
8.64
4.1
1.7
—
—
—
0
0
20
45
4.72
8.52
1.5
1.1
347.4
312.9
u/ml
—
10
24
18
37
5.14
8.49
2.9
2.7
5.6
4.9
e9/l
0.34
18
37
15
26
6.05
8.42
2.9
1.5
—
—
—
0
0
36
125
3.17
8.39
2.5
1.7
—
—
—
0
0
104
605
2.16
8.28
5.8
3.2
0.5
0.5
e6/l
0.01
90
452
220
1717
2.47
8.12
27.8
8.1
86.2
80.0
u/l
1.05
213
1607
18
39
4.87
8.00
2.9
3.2
59.4
60.7
%
0.13
18
39
183
1339
2.12
7.71
9.7
4.5
6.5
6.7
mmol/l
0.79
174
1252
129
838
2.03
7.47
3.1
2.3
78.9
76.8
nmol/l
0.33
120
737
87
489
2.15
7.44
3.4
1.7
1.6
1.4
mg/l
0.24
76
398
16
34
4.94
7.26
1.4
1.4
—
—
—
0
0
70
364
2.24
7.24
5.5
2.9
0.7
0.9
e6/l
0.54
52
212
11
8
14.26
6.95
1.4
1.3
—
—
—
0
0
11
8
14.26
6.95
4.3
3.3
109.4
95.2
%
—
11
8
11
17
6.70
6.83
1.5
1.4
—
—
—
0
0
29
101
3.09
6.71
2.3
1.4
4.1
3.9
g/l
0.17
21
75
29
101
3.09
6.71
2.3
1.4
8.1
7.5
g/l
0.69
21
80
29
101
3.09
6.71
2.3
1.4
—
—
—
0
0
132
890
1.94
6.64
4.2
2.6
448.1
147.5
ug/l
1.05
125
809
11
18
6.33
6.48
1.5
1.6
11.1
16.3
u/l
1.40
11
18
11
18
6.33
6.48
1.8
1.5
—
—
—
0
0
22
66
3.54
6.43
5.0
2.4
24.2
24.4
mmol/l
0.09
22
54
6
0
+∞
6.27
1.0
0.0
—
—
—
0
0
185
1413
1.97
6.24
6.9
4.3
19.0
2239.7
e6/l
—
5
33
88
527
1.99
6.18
8.2
2.5
—
—
—
0
0
67
363
2.12
6.17
3.6
2.5
10.4
13.2
umol/l
2.33
61
335
10
8
12.91
6.13
1.1
1.0
—
—
—
0
0
78
455
2.00
5.86
4.5
3.5
378.9
197.2
ng/l
0.60
65
360
26
95
2.92
5.54
2.5
1.5
3.5
3.2
g/l
0.65
21
77
60
324
2.09
5.53
3.5
2.5
18.2
23.3
%
1.25
50
286
17
48
3.71
5.42
2.9
1.5
—
—
—
0
0
126
879
1.81
5.37
2.5
2.0
98.4
93.8
pmol/l
0.54
88
455
93
593
1.86
5.29
7.8
2.9
337.2
7224.6
umol/l
2.68
84
517
19
59
3.39
5.28
2.2
1.5
—
—
—
0
0
60
336
2.01
4.99
3.5
2.5
2.1
2.3
g/l
1.31
55
311
9
10
9.26
4.82
2.2
1.5
—
—
—
0
0
9
10
9.26
4.82
2.2
1.5
—
—
—
0
0
9
10
9.26
4.82
2.2
1.5
—
—
—
0
0
9
10
9.26
4.82
2.2
1.5
—
—
—
0
0
70
420
1.90
4.74
1.8
1.7
983.0
1203.8
nmol/l
1.49
56
315
17
53
3.35
4.70
5.4
2.6
7.5
8.0
kpa
0.73
17
45
43
218
2.16
4.63
7.7
7.1
121.0
121.6
g/l
0.07
43
212
9
11
8.42
4.59
2.0
1.5
2737.4
1064.2
u/ml
—
9
11
9
11
8.42
4.59
2.9
1.3
37.0
68.5
ug/l
—
9
11
8
8
10.26
4.55
1.1
1.0
—
—
—
0
0
85
549
1.80
4.54
2.0
1.6
18.4
20.6
nmol/l
0.93
80
462
40
199
2.18
4.51
2.6
2.6
28.3
34.0
u/l
0.69
35
167
21
77
2.87
4.46
2.1
3.3
36.7
40.0
mg/l
0.13
16
63
9
12
7.71
4.39
1.7
1.6
—
—
—
0
0
7
6
11.93
4.30
1.1
1.0
—
—
—
0
0
7
6
11.93
4.30
2.0
1.7
—
—
—
0
0
9
13
7.12
4.19
1.7
1.5
—
—
—
0
0
10
23
4.48
4.12
1.3
1.1
—
—
—
0
0
8
10
8.20
4.09
1.3
1.1
2.0
1.8
mmol/l
—
8
10
125
920
1.66
4.08
4.6
3.8
32.7
44.6
ng/l
0.66
97
666
96
659
1.71
4.08
3.3
2.1
171.0
228.3
u/l
0.37
91
626
20
76
2.76
3.99
2.1
3.1
—
1.3
—
0
11
19
72
2.76
3.82
1.6
1.5
2.0
0.1
iu/ml
—
5
18
12
34
3.65
3.81
1.2
1.1
—
—
—
0
0
12
34
3.65
3.81
1.5
1.2
1.3
1.3
u/ml
—
6
10
8
12
6.83
3.70
2.0
1.6
—
—
—
0
0
133
1013
1.61
3.67
10.7
4.3
—
—
—
0
0
31
153
2.16
3.57
8.1
6.7
25.0
24.1
mmol/l
0.77
31
144
43
240
1.94
3.57
5.1
3.3
—
—
—
0
0
6
6
10.19
3.51
2.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
10
7.15
3.38
1.0
1.1
—
—
—
0
0
12
38
3.26
3.25
1.5
1.2
1.4
4.0
u/ml
—
5
16
8
16
5.12
3.07
1.9
2.0
—
—
—
0
0
8
16
5.12
3.07
1.9
2.0
—
—
—
0
0
9
21
4.39
3.02
1.3
1.0
—
—
—
0
0
198
2211
0.62
3.00
4.8
5.1
2.6
2.7
mmol/l
0.57
184
2011
192
2159
0.62
3.00
4.6
4.5
1.4
1.4
mmol/l
0.25
180
1967
8
17
4.81
2.94
1.5
1.3
—
—
—
0
0
6
9
6.79
2.88
1.3
1.0
—
—
—
0
0
5
6
8.46
2.76
1.2
1.0
—
—
—
0
0
9
25
3.69
2.60
1.2
1.1
—
—
u/ml
—
0
0
195
2168
0.64
2.59
4.6
4.6
4.5
4.5
mmol/l
0.22
183
1984
148
1226
1.45
2.40
3.4
2.7
—
—
—
0
0
7
20
3.56
2.07
14.1
3.7
—
—
—
0
0
11
44
2.56
2.04
1.4
1.5
—
—
—
0
0
5
11
4.61
1.95
2.4
1.1
—
—
—
0
0
12
52
2.37
1.90
1.2
1.2
—
—
—
0
0
7
22
3.24
1.89
1.4
3.6
—
—
—
0
0
7
23
3.10
1.81
1.6
1.5
9657.1
32223.5
e6/l
—
7
13
11
47
2.40
1.80
1.1
1.1
—
—
—
0
0
6
18
3.38
1.75
8.2
1.2
—
—
—
0
0
234
2172
1.55
1.75
59.1
15.1
30.7
25.0
mg/l
1.83
219
1725
11
48
2.35
1.73
1.1
1.2
—
56.4
—
0
5
14
70
2.05
1.62
1.9
2.5
—
—
—
0
0
8
32
2.54
1.61
1.0
1.2
—
—
—
0
0
6
20
3.04
1.59
1.0
1.1
—
—
—
0
0
211
1931
1.41
1.58
48.5
16.0
37.3
39.9
%
3.53
150
1362
164
1444
1.34
1.57
7.7
3.3
70.4
50.1
u/l
1.24
158
1350
192
2088
0.73
1.56
4.5
4.1
1.3
1.3
mmol/l
0.33
181
1899
5
15
3.37
1.53
1.6
1.0
—
—
—
0
0
7
27
2.63
1.52
1.0
1.6
—
—
—
0
0
6
21
2.90
1.51
1.0
1.0
—
—
—
0
0
12
59
2.08
1.46
1.5
1.2
—
—
—
0
0
5
16
3.16
1.44
2.2
1.2
—
—
—
0
0
6
22
2.76
1.44
1.0
1.1
—
—
—
0
0
125
1068
1.32
1.43
5.8
4.8
0.0
0.0
estimate
0.00
25
188
12
60
2.05
1.40
1.5
1.2
—
—
—
0
0
5
17
2.98
1.36
2.2
1.2
—
—
—
0
0
62
484
1.36
1.29
1.7
1.8
500.4
448.6
pmol/l
0.51
55
403
124
1071
1.29
1.27
4.2
3.6
0.0
0.0
estimate
0.00
23
194
125
1083
1.29
1.24
4.3
3.6
0.0
0.0
estimate
0.00
24
183
24
159
1.56
1.16
4.1
2.8
52.6
64.2
ml/min/173m2
0.72
12
73
191
2046
0.78
1.08
5.5
6.1
40.6
40.3
mmol/mol
0.17
178
1893
201
2132
0.78
0.98
5.3
4.7
6.0
6.0
mmol/l
0.25
193
1937
11
62
1.81
0.95
1.1
1.3
—
—
—
0
0
191
1788
1.23
0.81
59.7
18.9
14.6
13.7
%
4.49
191
1755
5
24
2.10
0.75
1.4
1.3
—
—
—
0
0
5
25
2.02
0.73
2.0
1.7
—
—
—
0
0
24
182
1.35
0.64
4.5
3.7
1.3
1.2
mmol/l
0.93
24
161
12
175
0.67
0.63
1.6
1.8
—
—
—
0
0
167
1565
1.17
0.61
3.7
3.6
14.9
14.9
pmol/l
0.13
153
1386
14
99
1.44
0.55
1.5
1.4
—
—
—
0
0
41
343
1.23
0.54
1.4
1.3
17.4
38.7
iu/ml
2.01
12
123
76
846
0.86
0.50
3.7
4.4
21.1
21.4
%
0.08
38
410
213
2060
1.16
0.42
40.2
14.0
80.2
79.5
ml/min/173m2
0.18
200
1696
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
36.1
—
0
10
0
17
0.00
0.41
0.0
1.0
—
549.9
—
0
11
6
42
1.44
0.36
1.0
1.0
—
—
—
0
0
12
154
0.77
0.33
2.0
1.6
—
—
—
0
0
29
252
1.17
0.28
4.6
4.4
3.8
53.4
ug/l
0.94
24
210
37
332
1.13
0.25
1.3
1.3
4.2
13.2
u/ml
1.01
13
135
14
168
0.82
0.23
2.0
1.8
—
—
—
0
0
34
307
1.12
0.21
1.3
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
25
278
0.89
0.18
11.0
7.3
—
—
—
0
0
62
585
1.08
0.17
4.2
3.8
0.0
0.0
estimate
0.00
24
185
6
77
0.77
0.16
2.5
1.8
—
—
—
0
0
48
452
1.08
0.14
1.2
1.2
1.0
1.4
u/ml
0.36
16
127
54
565
0.94
0.11
1.9
1.7
1.4
1.4
mmol/l
0.02
46
461
88
853
1.05
0.10
4.2
3.7
—
—
—
0
0
5
64
0.78
0.08
1.2
1.2
—
—
—
0
0
22
207
1.07
0.06
1.4
1.4
—
—
—
0
0
60
608
0.98
0.01
3.2
3.0
0.6
0.8
ug/l
1.46
47
402
196
1958
1.00
0.00
4.5
4.4
1.8
2.0
mu/l
1.04
181
1755
104
1043
1.00
0.00
5.0
5.0
2.0
2.6
ug/l
1.00
92
937
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.3
—
0
6
6
63
0.95
0.00
1.7
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
5
53
0.94
0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint AB1_ASPERGILLOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_ASPERGILLOSIS | 4.089 [3.03, 5.52] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.199 |
During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 432 females with AB1_ASPERGILLOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_ASPERGILLOSIS | 5.317 [4.05, 6.99] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 377 out of 732 males with AB1_ASPERGILLOSIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_ASPERGILLOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.413% | 0.945% |
| 5 | 2.448% | 6.264% |
| 10 | 6.095% | 14.861% |
| 15 | 11.683% | 27.194% |
| 20 | 19.595% | 41.719% |
Relationships between endpoints
↥Index endpoint: AB1_ASPERGILLOSIS – Aspergillosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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