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Malignant neoplasm of other endocrine glands and related structures, excluding all cancers (controls excluding all cancers)

C3_ENDOCRINE_NAS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C75
  • Hospital discharge: ICD-9 194[1-9]
  • Hospital discharge: ICD-8 194[1-9]
  • Cause of death: ICD-10 C75
  • Cause of death: ICD-9 194[1-9]
  • Cause of death: ICD-8 194[1-9]
  • Cancer registry: Topography ICD-O-3 C75
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

161

4. Check minimum number of events

None

161

5. Include endpoints

None

161

6. Filter based on genotype QC (FinnGen only)

161

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of other endocrine glands and related structures, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 161 94 67
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 55.89 49.55 64.79

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
40
32
16.30
42.55
1.6
1.2
—
—
—
0
0
89
337
4.67
21.21
11.1
2.7
7.4
7.4
ph
0.55
31
46
21
19
12.56
20.19
3.0
1.2
—
—
—
0
0
19
20
10.64
16.44
2.8
1.2
—
—
nmol/l
—
0
0
101
519
3.54
13.69
15.1
5.6
1.2
1.2
mmol/l
0.91
96
466
107
585
3.47
12.82
15.2
5.7
1.2
1.2
mmol/l
0.68
76
504
34
89
4.58
12.40
8.5
3.4
117.2
79.7
ng/l
0.79
28
77
11
13
9.01
8.56
3.6
1.4
—
—
—
0
0
12
16
8.02
8.53
3.0
2.5
—
—
—
0
0
28
94
3.40
7.07
3.5
3.2
—
—
—
0
0
62
330
2.43
6.58
3.0
2.1
—
—
—
0
0
99
1273
0.42
6.22
4.3
4.4
1.4
1.5
mmol/l
1.07
91
1175
104
1307
0.42
5.98
4.7
4.9
2.6
2.7
mmol/l
0.31
94
1211
94
1224
0.44
5.79
3.8
4.0
1.4
1.2
mmol/l
1.60
85
1118
69
407
2.22
5.59
2.1
1.7
—
—
—
0
0
20
63
3.48
5.53
8.2
10.1
96.0
93.1
%
2.57
20
63
102
1282
0.44
5.51
4.3
4.4
4.5
4.6
mmol/l
0.33
94
1192
8
5
16.72
5.47
2.1
1.2
56.8
62.2
nmol/l
—
8
5
25
92
3.03
5.40
1.3
1.1
—
—
—
0
0
73
451
2.13
5.17
11.4
9.9
1.3
1.3
inr
0.03
31
127
19
61
3.40
5.10
10.3
5.6
24.5
25.3
mmol/l
0.46
19
61
7
5
14.54
4.62
2.6
1.2
21.0
21.8
ug/l
—
7
5
88
601
2.02
4.60
10.3
3.6
15.4
11.3
umol/l
0.32
81
555
44
232
2.23
4.56
2.5
2.5
500.5
541.1
mosm/kgh2o
0.68
39
181
23
89
2.85
4.54
9.4
8.6
—
—
—
0
0
75
491
1.99
4.36
6.4
3.7
34.8
35.8
g/l
0.67
69
457
54
326
1.99
3.87
3.1
2.5
—
—
—
0
0
15
51
3.14
3.68
1.7
1.3
21.8
20.7
iu/l
—
10
43
58
367
1.91
3.58
3.5
2.8
83.5
251.6
e6/l
0.40
49
261
6
6
10.32
3.52
2.8
1.0
—
—
—
0
0
54
337
1.91
3.46
3.2
2.6
0.4
0.4
e6/l
0.18
47
229
8
14
5.95
3.38
2.5
1.2
—
—
—
0
0
14
50
2.97
3.17
9.0
11.1
24.1
25.1
mmol/l
0.82
14
44
8
16
5.20
3.09
3.0
4.3
63.9
62.3
%
—
8
16
8
16
5.20
3.09
2.9
3.2
5.0
5.5
e9/l
—
8
16
58
383
1.80
3.06
6.7
4.6
—
—
—
0
0
9
21
4.47
3.04
4.1
1.7
4.7
4.8
kpa
—
9
21
9
21
4.47
3.04
4.1
1.7
8.8
8.1
kpa
—
9
21
5
5
10.26
3.00
10.0
4.0
4.0
1.6
ug/l
—
5
5
30
161
2.06
2.91
2.0
2.1
—
—
—
0
0
63
434
1.74
2.84
4.3
3.2
154.1
104.6
e6/l
0.31
51
281
6
10
6.18
2.72
1.8
1.2
—
—
—
0
0
9
24
3.91
2.71
1.8
1.3
—
—
—
0
0
10
33
3.16
2.57
1.5
1.6
22.1
19.9
s
—
10
28
24
124
2.10
2.57
6.9
11.3
0.3
1.5
mmol/l
0.67
19
100
20
96
2.24
2.56
12.3
6.9
1.1
1.4
mmol/l
1.34
20
89
45
291
1.76
2.49
12.9
4.9
—
—
—
0
0
27
148
1.99
2.47
1.4
1.2
—
—
—
0
0
6
12
5.15
2.42
6.8
1.4
3.1
310.8
u/ml
—
6
12
114
946
1.70
2.41
14.3
4.8
88.8
75.8
u/l
1.35
108
861
5
8
6.40
2.39
1.4
1.6
—
—
—
0
0
74
552
1.63
2.38
16.1
7.2
0.0
0.0
e9/l
0.61
63
429
16
72
2.36
2.36
2.7
1.2
—
—
—
0
0
45
295
1.73
2.36
6.7
3.7
—
—
—
0
0
48
321
1.71
2.35
1.6
1.4
—
—
—
0
0
23
122
2.03
2.30
9.3
3.9
—
—
—
0
0
110
1260
0.60
2.26
5.2
4.5
6.0
6.0
mmol/l
0.15
98
1148
133
1449
0.53
2.24
38.6
17.1
7.0
6.7
e9/l
1.30
128
1396
133
1449
0.53
2.24
38.6
17.1
4.4
4.5
e12/l
0.88
128
1395
86
678
1.58
2.13
17.8
5.9
4.3
4.3
e9/l
0.03
77
588
133
1446
0.54
2.12
38.6
17.1
250.2
249.9
e9/l
0.01
128
1398
5
10
5.12
2.08
2.6
1.0
—
—
—
0
0
7
20
3.61
2.08
3.1
1.6
—
—
—
0
0
13
57
2.39
2.03
14.9
3.8
23.3
24.7
mmol/l
0.76
13
51
6
16
3.85
1.95
1.2
1.1
—
—
—
0
0
40
269
1.65
1.89
5.2
4.3
—
—
—
0
0
27
165
1.76
1.79
2.3
2.6
145.4
92.3
ug/g
0.29
22
121
16
83
2.03
1.71
3.4
4.2
1.3
0.8
%
—
8
16
6
19
3.24
1.67
1.0
1.1
—
—
—
0
0
15
79
1.99
1.55
3.5
4.4
0.9
0.1
%
—
7
14
99
1126
0.69
1.47
35.6
15.5
331.6
332.6
g/l
0.37
99
1121
44
323
1.50
1.41
5.0
3.8
0.0
0.0
estimate
0.00
22
89
18
105
1.80
1.40
2.5
2.2
72.0
65.9
e9/l
—
10
84
14
75
1.95
1.39
3.7
4.4
0.2
0.0
%
—
6
13
114
1004
1.46
1.38
7.8
3.8
15.5
14.7
pmol/l
2.35
109
905
73
601
1.39
1.25
7.5
4.7
0.6
0.6
e9/l
0.07
64
516
14
79
1.85
1.21
1.1
1.2
58.4
118.7
iu/ml
—
8
30
36
262
1.48
1.20
2.1
1.8
537.7
26635951.8
pmol/l
0.50
28
214
73
605
1.38
1.19
7.5
4.7
0.0
0.0
e9/l
1.31
64
522
129
1381
0.67
1.16
15.7
8.3
27.0
24.5
u/l
1.00
120
1318
6
125
0.46
1.10
1.3
1.3
—
—
—
0
0
74
621
1.35
1.09
7.9
4.8
1.7
1.9
e9/l
1.10
66
544
5
108
0.45
1.05
2.8
2.3
—
10.4
—
0
5
5
22
2.31
1.04
24.0
4.4
—
—
—
0
0
74
625
1.34
1.03
8.8
5.1
0.1
0.2
e9/l
2.25
66
549
35
261
1.44
1.03
1.5
1.7
1.8
1.1
mg/l
0.47
20
203
12
69
1.80
0.99
1.1
1.3
—
—
—
0
0
25
176
1.50
0.98
2.1
1.6
—
—
—
0
0
19
127
1.56
0.93
1.3
1.3
—
—
—
0
0
97
861
1.32
0.93
3.7
3.6
—
—
—
0
0
109
1186
0.75
0.90
6.4
6.2
41.1
40.5
mmol/mol
0.29
98
1108
12
72
1.72
0.88
1.1
1.4
—
—
—
0
0
128
1358
0.72
0.86
23.0
10.9
—
—
—
0
0
8
47
1.74
0.82
6.3
3.7
—
—
—
0
0
7
123
0.55
0.82
2.3
2.5
4.8
6.2
ug/l
—
7
111
7
125
0.54
0.81
1.7
1.7
—
—
—
0
0
8
48
1.70
0.80
1.0
1.2
—
—
—
0
0
45
368
1.31
0.76
3.1
3.2
—
—
—
0
0
9
58
1.58
0.71
14.1
2.5
1.3
1.3
%
—
9
58
71
621
1.26
0.70
4.5
3.5
0.0
0.0
estimate
0.00
23
95
14
96
1.50
0.64
10.8
3.0
6.6
4.1
kpa
1.15
14
90
6
35
1.74
0.58
4.3
2.0
9.3
9.0
kpa
—
6
30
8
54
1.51
0.58
12.5
18.3
—
—
—
0
0
16
215
0.72
0.57
1.5
1.3
2.4
12.5
u/ml
—
5
87
31
252
1.29
0.55
2.4
1.7
1405.0
1107.9
nmol/l
0.60
20
195
6
39
1.56
0.53
1.8
1.4
5.7
2.1
ug/l
—
6
33
19
145
1.35
0.51
1.5
1.7
—
—
—
0
0
65
579
1.21
0.51
4.2
2.6
173.0
107.5
ug/l
0.59
58
535
70
628
1.20
0.51
5.7
4.9
0.0
0.0
estimate
0.00
22
95
71
639
1.20
0.50
4.5
3.5
0.0
0.0
estimate
0.00
23
91
16
120
1.37
0.48
2.4
1.5
—
—
—
0
0
37
432
0.81
0.47
3.5
3.2
—
—
—
0
0
17
215
0.77
0.42
1.5
1.3
14.3
33.3
iu/ml
—
7
76
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
5
77
0.64
0.36
2.2
3.5
—
—
—
0
0
26
219
1.22
0.36
2.3
1.9
—
—
—
0
0
32
367
0.84
0.34
3.0
3.9
—
—
—
0
0
6
46
1.32
0.33
1.5
1.1
—
—
—
0
0
10
74
1.37
0.33
2.0
2.4
—
—
—
0
0
6
47
1.29
0.32
2.2
1.5
—
—
—
0
0
34
298
1.18
0.32
3.9
2.3
349.9
10038.4
umol/l
2.03
26
253
93
883
1.13
0.28
4.7
4.1
—
—
—
0
0
32
284
1.16
0.26
4.8
3.5
—
—
—
0
0
9
75
1.21
0.25
4.6
10.7
—
—
—
0
0
37
335
1.14
0.23
1.6
1.7
1.4
1.3
mmol/l
0.30
27
283
7
93
0.74
0.23
1.0
1.3
—
—
—
0
0
115
1187
0.89
0.23
24.8
12.8
38.0
39.9
%
1.15
81
857
5
42
1.20
0.21
2.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
3.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
6.6
—
0
7
0
13
0.00
0.21
0.0
1.2
—
3.7
—
0
8
6
48
1.26
0.20
1.3
1.3
—
1.6
—
0
6
6
48
1.26
0.20
7.3
3.3
25.8
24.9
mmol/l
—
6
48
6
50
1.21
0.20
1.3
1.1
—
—
—
0
0
53
496
1.10
0.19
4.0
3.4
—
—
—
0
0
42
389
1.11
0.18
3.9
3.2
115.5
212.3
mg/l
0.23
29
255
46
492
0.91
0.18
4.8
3.8
33.4
108.9
ng/l
0.53
37
338
9
81
1.12
0.15
5.4
2.6
5.4
5.1
kpa
—
9
73
119
1215
0.92
0.13
8.1
4.6
1.6
1.8
mu/l
1.08
110
1102
28
259
1.10
0.12
1.3
1.3
2.7
2.4
g/l
0.20
18
144
11
126
0.86
0.11
1.2
1.5
—
—
—
0
0
12
105
1.15
0.11
3.8
3.2
—
—
—
0
0
10
86
1.17
0.11
4.8
2.2
—
—
—
0
0
38
359
1.08
0.11
4.0
3.1
—
—
—
0
0
6
55
1.09
0.09
7.7
3.0
—
—
—
0
0
43
419
1.04
0.03
3.3
3.1
7.5
7.6
mmol/l
0.01
35
350
41
420
0.97
0.03
4.7
4.0
20.3
7.4
mg/mmol
0.49
26
279
10
108
0.92
0.03
1.1
1.1
—
—
—
0
0
31
301
1.04
0.02
1.1
1.4
0.9
1.2
u/ml
—
7
76
127
1279
0.97
0.02
22.8
11.8
25.7
22.6
mg/l
0.51
114
976
53
539
0.98
0.02
2.0
1.9
92.3
92.9
pmol/l
0.04
33
270
14
147
0.95
0.01
2.4
1.6
—
—
—
0
0
13
134
0.97
0.00
1.2
2.0
—
—
—
0
0
20
196
1.02
0.00
3.8
2.6
0.7
0.8
ug/l
0.13
14
137
10
103
0.97
0.00
11.7
2.9
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
4.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
4.3
—
0
5
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
133.8
—
0
8
0
6
0.00
0.00
0.0
7.0
—
4.7
—
0
6
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
31.6
—
0
7
5
56
0.89
0.00
1.6
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
3.2
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
116.7
—
0
6
7
79
0.88
0.00
1.3
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.6
—
—
—
0
0
5
49
1.02
0.00
1.8
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
0.00
1.3
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_ENDOCRINE_NAS_EXALLC – Malignant neoplasm of other endocrine glands and related structures, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).