No definition available.
Benign neoplasm: Ill-defined sites within the digestive system
CD2_BENIGN_DIGESTIVE_NOS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
208 |
4. Check minimum number of eventsNone |
208 |
5. Include endpointsNone |
208 |
6. Filter based on genotype QC (FinnGen only) |
208 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D13
- Name in latin
- Neoplasma benignum systematis digestorii loco male specificato
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Ill-defined sites within the digestive system
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Ill-defined sites within the digestive system
- Benign neoplasm of other and ill-defined parts of digestive system
- Benign neoplasm of other and ill-defined parts of digestive system
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1435 | 836 | 586 |
| Only index persons | 1139 | 692 | 447 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 61.79 | 60.50 | 63.56 |
| Only index persons | 60.47 | 58.95 | 62.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 208 | 137 | 71 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 61.18 | 59.51 | 64.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 186
- Matched controls
- 1860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D13.9
ICD-10 Finland
Benign neoplasm: Ill-defined sites within the digestive system
+∞
205.2
157
*
21199
ICD-8 Finland
Benign neoplasm of other parts of digestive system, Unspecified site
+∞
19.1
18
*
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
17.6
16.8
26
17
A09AA02
ATC
multienzymes (lipase, protease etc.)
21.6
16.0
23
12
WX302
NOMESCO Finland
Thoracal epidural anesthesy
8.9
14.4
31
41
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
23.2
12.3
17
8
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.5
10.9
41
111
D13.6
ICD-10 Finland
Benign neoplasm: Pancreas
63.8
10.8
12
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
10.6
79
368
TPH07
NOMESCO Finland
Cathetrisation of artery
4.7
10.4
37
94
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
4.9
8.9
29
67
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
13.6
8.5
14
11
2119X
ICD-9 Finland
Benign neoplasm of other parts of digestive system, Other and unspecified site[NEOPLASMA BENIGNUM ALIUD ORG DIGEST AL DEF SEU NUD]
+∞
8.4
8
*
A02BC02
ATC
pantoprazole; systemic
2.7
8.4
139
978
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
8.0
82
440
D13.0
ICD-10 Finland
Benign neoplasm: Oesophagus
83.3
7.5
8
*
JAH00
NOMESCO Finland
Laparotomy
7.8
7.4
16
22
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
23.5
6.7
9
*
130
Kela drug reimbursment
Malignant tumour
4.3
6.7
24
62
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
6.6
64
327
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
8.1
6.2
13
17
WX402
NOMESCO Finland
General anaesthesia
2.9
6.0
40
163
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
60
198
3.85
15.94
3.7
3.3
6.6
7.2
umol/l
0.10
54
176
19
22
9.40
15.25
4.4
2.0
4.9
4.3
nmol/l
0.10
19
22
29
60
5.45
13.78
1.3
1.4
281.0
289.0
ug/g
0.06
20
30
59
214
3.45
13.38
4.4
4.3
13.9
8.3
ug/l
0.42
47
185
36
92
4.52
13.37
2.6
3.1
582.1
1667.8
u/ml
0.29
28
76
45
148
3.60
11.76
2.9
2.3
0.2
0.2
g/l
0.15
45
138
46
164
3.32
10.54
3.1
2.5
34.5
28.5
u/l
0.70
46
137
128
783
2.65
10.50
6.6
4.4
35.2
35.1
g/l
0.03
121
736
100
580
2.39
8.69
3.5
2.4
62.1
56.8
u/l
0.65
93
538
96
547
2.40
8.69
3.7
3.3
34.4
30.4
u/l
0.52
91
527
18
45
4.28
6.78
1.2
1.3
—
—
—
0
0
128
904
2.08
6.07
7.3
6.1
1.2
1.2
mmol/l
0.05
106
763
52
272
2.22
5.37
2.6
2.1
12.5
13.0
umol/l
0.17
46
250
11
22
5.22
5.32
1.4
1.4
—
—
—
0
0
25
96
2.82
4.94
5.6
4.6
24.3
25.1
mmol/l
0.51
25
96
80
512
1.91
4.70
3.4
2.9
0.2
0.7
e6/l
1.93
56
377
136
1035
1.91
4.62
5.3
4.8
7.1
6.7
mmol/l
1.05
130
964
44
233
2.13
4.35
2.9
2.2
19.6
22.4
%
0.66
37
205
112
822
1.79
4.08
7.9
5.4
1.2
1.2
mmol/l
0.10
107
748
56
334
1.93
3.98
3.4
3.5
181.2
106.7
ng/l
0.24
45
272
43
237
2.03
3.81
5.1
5.9
103.6
103.7
mmol/l
0.08
43
230
166
1395
1.94
3.64
13.2
7.5
85.2
78.1
u/l
0.97
161
1301
127
996
1.71
3.42
17.1
9.6
4.0
4.1
e9/l
0.05
106
886
90
649
1.68
3.28
3.4
3.0
—
—
—
0
0
39
219
1.96
3.27
7.1
4.7
1.1
1.1
mmol/l
0.01
39
205
97
716
1.66
3.22
3.6
2.5
127.9
116.8
ug/l
0.25
90
658
97
721
1.65
3.11
2.9
2.1
80.7
78.7
nmol/l
0.26
86
636
26
130
2.14
2.96
1.4
1.6
—
—
—
0
0
34
192
1.92
2.80
4.6
3.5
—
—
—
0
0
31
171
1.96
2.73
3.5
3.5
6.0
5.8
kpa
0.36
31
166
46
289
1.76
2.71
3.2
2.9
4.9
2.9
e6/l
0.19
17
152
35
202
1.88
2.70
1.7
1.9
—
—
—
0
0
44
277
1.75
2.57
1.8
1.8
29.7
29.4
s
0.17
44
269
44
278
1.74
2.53
1.7
2.0
—
—
—
0
0
51
341
1.66
2.38
5.8
3.0
2.4
2.5
mmol/l
0.30
46
300
7
17
4.22
2.38
1.4
1.2
59.3
57.4
u/l
—
7
12
35
211
1.79
2.36
4.0
6.2
0.9
1.5
mmol/l
0.39
25
170
104
826
1.52
2.30
5.3
4.0
—
—
—
0
0
92
712
1.52
2.30
2.3
1.9
96.9
96.5
pmol/l
0.03
45
344
9
29
3.20
2.25
1.9
1.4
233.1
319.5
mu/l
—
9
29
33
199
1.78
2.22
1.7
1.8
—
—
—
0
0
9
210
0.40
2.22
11.4
8.4
—
—
—
0
0
58
413
1.56
2.08
2.9
2.0
3.5
3.2
mg/l
0.27
53
355
46
310
1.62
2.08
3.2
2.7
0.5
1.2
e6/l
1.47
16
171
9
33
2.80
1.95
1.6
1.5
—
—
—
0
0
9
33
2.80
1.95
1.6
1.5
—
—
—
0
0
6
16
3.83
1.95
1.0
1.0
—
—
—
0
0
162
1442
1.56
1.89
32.7
17.7
13.9
13.7
%
1.00
157
1414
129
1097
1.46
1.89
4.5
3.2
64.2
51.1
u/l
0.64
120
1022
15
74
2.11
1.80
1.1
2.2
7.6
7.7
g/l
—
8
64
15
74
2.11
1.80
1.1
2.2
—
—
—
0
0
15
74
2.11
1.80
1.1
2.2
4.0
3.8
g/l
—
8
61
5
13
3.91
1.72
1.0
1.1
329.0
299.0
u/l
—
5
13
10
42
2.45
1.70
1.8
1.4
—
—
—
0
0
24
144
1.75
1.66
2.6
2.8
4.0
4.1
kpa
0.14
24
139
192
1799
1.87
1.64
25.4
16.9
139.3
139.8
mmol/l
1.68
187
1750
14
70
2.07
1.63
1.1
2.3
3.1
3.2
g/l
—
8
63
17
92
1.92
1.61
3.8
3.6
4.1
4.4
pmol/l
1.50
17
79
7
26
2.75
1.59
2.3
1.2
—
—
nmol/l
—
0
0
185
1721
1.68
1.54
25.2
14.6
27.6
22.5
mg/l
1.19
159
1357
192
1805
1.83
1.53
25.9
17.0
4.0
4.0
mmol/l
0.54
187
1756
60
458
1.44
1.51
3.1
2.7
325.8
8404.5
umol/l
2.75
54
390
103
869
1.37
1.43
3.7
3.9
0.0
0.0
estimate
0.00
25
175
193
1824
1.81
1.40
27.0
17.6
80.8
76.2
umol/l
0.78
193
1824
9
41
2.25
1.39
1.7
1.6
—
—
—
0
0
16
90
1.84
1.37
1.1
1.0
—
—
—
0
0
9
43
2.14
1.32
1.3
1.6
—
—
—
0
0
6
25
2.44
1.25
1.2
1.0
—
—
—
0
0
52
400
1.40
1.24
3.1
2.4
—
—
—
0
0
17
101
1.74
1.24
1.5
1.3
—
—
—
0
0
55
430
1.38
1.19
1.7
1.5
21.0
20.9
nmol/l
0.00
49
354
5
20
2.54
1.16
1.4
1.2
—
—
—
0
0
17
104
1.69
1.13
1.4
1.7
—
—
—
0
0
10
51
2.01
1.13
1.3
1.2
—
—
—
0
0
102
884
1.30
1.09
5.0
5.2
0.0
0.0
estimate
0.00
22
173
9
48
1.91
1.02
1.2
1.8
—
—
—
0
0
5
23
2.20
0.98
1.4
1.7
—
—
—
0
0
5
23
2.20
0.98
1.2
1.3
—
—
—
0
0
102
893
1.28
0.98
3.9
3.9
0.0
0.0
estimate
0.00
24
169
7
36
1.98
0.98
1.6
1.4
—
—
—
0
0
7
37
1.92
0.95
1.1
1.2
2.4
169.7
e6/l
—
7
29
7
37
1.92
0.95
1.3
1.2
0.6
0.9
nmol/l
—
7
32
8
42
1.94
0.89
1.4
1.6
—
—
—
0
0
173
1632
1.36
0.87
25.0
13.9
77.1
78.1
ml/min/173m2
0.22
149
1335
8
45
1.81
0.85
1.4
1.2
—
—
—
0
0
6
31
1.96
0.85
1.5
1.6
—
—
—
0
0
6
32
1.90
0.82
1.3
1.7
—
—
—
0
0
14
210
0.64
0.82
4.1
4.5
30.3
32.5
%
—
7
137
0
26
0.00
0.79
0.0
3.6
—
20.3
—
0
7
7
38
1.87
0.74
1.6
1.1
—
—
—
0
0
7
40
1.78
0.72
1.3
1.8
—
—
—
0
0
5
27
1.87
0.69
1.6
1.7
—
—
—
0
0
5
27
1.87
0.69
1.6
1.3
—
—
—
0
0
190
1835
1.41
0.66
16.5
10.8
26.0
24.5
u/l
0.81
184
1770
7
44
1.61
0.66
2.1
1.7
—
—
—
0
0
29
227
1.32
0.64
9.1
20.0
1.1
1.2
inr
—
5
30
47
398
1.23
0.57
1.3
1.2
0.5
1.8
u/ml
1.62
12
118
159
1515
1.21
0.52
27.5
15.6
37.9
39.6
%
1.25
115
1058
46
395
1.21
0.50
2.1
1.6
1.3
1.4
mg/l
0.08
41
309
7
47
1.51
0.48
4.0
2.1
25.7
25.6
mmol/l
—
7
37
55
485
1.18
0.45
4.3
4.0
0.0
0.0
estimate
0.00
23
167
167
1606
1.20
0.45
5.2
4.8
1.9
1.9
mu/l
0.12
157
1453
7
51
1.39
0.44
2.3
2.5
—
—
—
0
0
8
56
1.45
0.43
1.3
2.6
0.0
0.0
g/l
—
8
56
8
56
1.45
0.43
1.3
2.6
0.0
0.0
g/l
—
8
56
8
57
1.42
0.42
1.3
2.6
0.0
0.0
g/l
—
8
57
31
260
1.23
0.42
1.5
1.4
—
—
—
0
0
170
1641
1.20
0.42
6.7
5.9
41.1
40.2
mmol/mol
0.55
160
1525
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.3
—
64.4
—
0
11
75
684
1.15
0.40
4.0
4.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
13
98
1.35
0.38
1.0
1.1
392.5
148.2
iu/ml
—
6
41
5
36
1.40
0.38
1.4
1.4
—
—
—
0
0
34
293
1.19
0.36
1.2
1.3
17.2
12.5
u/ml
0.14
16
112
40
351
1.17
0.35
2.0
1.7
1200.5
1245.7
nmol/l
0.10
30
266
55
496
1.15
0.34
1.8
1.6
1.4
1.3
mmol/l
0.29
49
414
176
1712
1.18
0.34
4.7
4.8
6.0
6.0
mmol/l
0.08
163
1567
140
1348
1.12
0.28
4.2
4.0
14.6
14.8
pmol/l
0.54
128
1210
8
62
1.30
0.28
1.1
1.2
—
—
—
0
0
12
97
1.25
0.23
2.5
2.6
1.1
1.1
%
0.10
12
97
53
490
1.11
0.23
5.1
5.2
2.0
2.8
ug/l
0.43
47
432
5
42
1.20
0.21
1.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
7
61
1.15
0.17
1.1
1.2
—
—
—
0
0
7
61
1.15
0.17
1.3
2.1
—
—
—
0
0
42
391
1.09
0.16
4.6
4.5
24.8
20.9
%
0.58
14
191
101
977
1.07
0.15
3.0
2.8
—
—
—
0
0
32
296
1.10
0.14
2.7
3.1
0.8
0.7
ug/l
0.05
21
203
10
117
0.85
0.13
1.5
1.9
—
—
—
0
0
11
95
1.17
0.12
1.1
1.3
—
—
—
0
0
31
289
1.09
0.11
1.5
1.4
—
—
—
0
0
69
716
0.95
0.11
3.8
3.9
42.0
38.8
ng/l
0.06
46
517
168
1702
0.93
0.11
4.2
4.6
1.5
1.5
mmol/l
1.34
153
1557
162
1640
0.94
0.09
3.7
4.1
1.2
1.3
mmol/l
0.91
150
1495
6
55
1.09
0.09
2.0
1.3
—
—
—
0
0
6
57
1.05
0.08
1.3
1.9
—
—
—
0
0
5
60
0.83
0.08
1.6
1.7
—
—
—
0
0
14
127
1.11
0.08
1.5
1.7
—
—
—
0
0
170
1714
0.96
0.05
4.3
4.6
4.5
4.7
mmol/l
1.28
155
1576
10
109
0.91
0.04
1.5
1.6
—
—
—
0
0
29
301
0.96
0.04
1.3
1.3
13.4
40.2
iu/ml
2.86
14
104
55
560
0.98
0.02
2.8
3.2
1674.8
1172.5
ng/l
0.28
47
476
176
1752
1.03
0.02
5.0
5.2
2.6
2.7
mmol/l
0.61
160
1605
11
104
1.06
0.01
3.5
3.1
5.4
5.2
kpa
0.39
11
95
40
396
1.01
0.00
2.1
1.7
398.8
449.2
pmol/l
0.78
30
324
16
158
1.01
0.00
1.7
2.7
72.4
62.1
ml/min/173m2
—
7
66
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
1.8
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
11.9
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_DIGESTIVE_NOS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_DIGESTIVE_NOS | 1.908 [1.49, 2.44] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.146 |
During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 500 females with CD2_BENIGN_DIGESTIVE_NOS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_DIGESTIVE_NOS | 1.995 [1.48, 2.68] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 139 out of 332 males with CD2_BENIGN_DIGESTIVE_NOS died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_DIGESTIVE_NOS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.224% | 0.335% |
| 5 | 1.08% | 2.077% |
| 10 | 2.401% | 5.039% |
| 15 | 4.887% | 9.237% |
| 20 | 8.89% | 15.301% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_DIGESTIVE_NOS – Benign neoplasm: Ill-defined sites within the digestive system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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