No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
267 |
4. Check minimum number of eventsNone |
267 |
5. Include endpointsNone |
267 |
6. Filter based on genotype QC (FinnGen only) |
259 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H73
- Name in latin
- Myringitis acuta
Similar endpoints
↥List of similar endpoints to
Acute myringitis
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3427 | 1705 | 1712 |
| Only index persons | 2624 | 1359 | 1265 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 11.72 | 13.87 | 9.40 |
| Only index persons | 19.24 | 21.74 | 16.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 259 | 167 | 92 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 39.54 | 36.41 | 45.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 267
- Matched controls
- 2670
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H73.0
ICD-10 Finland
Acute myringitis
14704.1
307.7
252
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
14.2
88.3
98
105
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
42.9
40
*
H66.9
ICD-10 Finland
Otitis media, unspecified
8.4
39.5
58
85
UDC00
NOMESCO Finland
Ear microscopy
8.2
37.8
57
86
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
125.0
31.4
33
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
55.4
29.2
34
7
H65.3
ICD-10 Finland
Chronic mucoid otitis media
286.8
26.2
26
*
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
25.4
24
*
H92.0
ICD-10 Finland
Otalgia
6.0
22.1
43
83
DCD00
NOMESCO Finland
Myringoplasty
+∞
19.0
18
*
H01
ICPC
Ear pain/earache
3.8
17.9
66
212
H65.0
ICD-10 Finland
Acute serous otitis media
22.7
16.3
23
11
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
15.8
15
*
3840A
ICD-9 Finland
Other disorders of tympanic membrane, Acute myringitis without mention of otitis media
+∞
15.8
15
*
DFF00
NOMESCO Finland
Pure tone audiometry
4.5
14.9
40
101
H60.9
ICD-10 Finland
Otitis externa, unspecified
4.5
14.9
40
101
S02CA02
ATC
flumetasone and antiinfectives; otic
5.6
13.5
27
53
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.4
12.8
53
182
DC1AD
NOMESCO Finland
Temporalbone CT
73.4
12.7
14
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
12.6
12
*
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
49.0
12.0
14
*
4122
FHL
Tympanostomy (tympanic tube)
125.2
11.5
12
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
10.8
169
1111
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
62.6
10.7
12
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
10.5
10
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
9.4
9
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.3
9.0
94
511
TDA90
NOMESCO Finland
Removal wax from ear
13.3
8.5
14
11
H60.3
ICD-10 Finland
Other infective otitis externa
9.0
8.4
17
20
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
7.6
113
698
H02AB06
ATC
prednisolone; systemic
2.0
7.5
125
805
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
7.3
63
312
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
7.3
7
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
30.9
7.2
9
*
J01DA08
ATC
[U] cefaclor
2.6
6.9
43
183
4451
FHL
Guitar cutting
6.4
6.9
17
28
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
8.1
6.7
14
18
M54.5
ICD-10 Finland
Low back pain
2.0
6.6
103
640
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
6.4
75
420
EMB30
NOMESCO Finland
Adenotomy
7.3
6.3
14
20
ZZG00
NOMESCO Finland
Graft of cartilage
+∞
6.3
6
*
M54.4
ICD-10 Finland
Lumbago with sciatica
2.3
6.2
55
275
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.3
6.2
16
39
J01CA04
ATC
amoxicillin; systemic
2.5
6.0
235
1984
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
133
1004
1.65
3.91
3.4
2.5
—
—
—
0
0
118
865
1.65
3.89
6.8
6.9
1.20
1.21
mmol/l
1.11
108
797
99
703
1.65
3.64
3.8
3.0
—
—
—
0
0
51
300
1.87
3.63
2.2
1.7
—
—
—
0
0
151
1207
1.58
3.30
5.3
5.0
6.47
6.60
mmol/l
0.21
142
1094
87
619
1.60
3.10
3.2
2.4
63.27
59.22
u/l
0.12
78
577
99
728
1.57
3.06
2.0
1.8
99.96
95.05
pmol/l
0.64
62
384
79
553
1.61
2.99
4.1
2.9
0.42
0.41
e6/l
0.02
58
412
8
19
4.31
2.70
1.4
1.6
13.00
13.26
%
—
8
19
26
135
2.03
2.66
1.7
1.5
—
—
—
0
0
175
1487
1.51
2.61
3.4
3.0
39.66
41.26
u/l
0.17
164
1411
12
42
2.94
2.58
1.0
1.2
3.40
2.67
u/ml
—
5
21
12
42
2.94
2.58
1.2
1.5
—
—
—
0
0
15
64
2.42
2.43
1.5
1.6
—
—
—
0
0
71
508
1.54
2.40
3.3
2.2
—
—
—
0
0
119
947
1.46
2.40
8.8
7.3
1.21
1.21
mmol/l
0.66
105
817
16
71
2.33
2.39
1.7
1.8
—
—
—
0
0
103
803
1.46
2.29
16.3
11.4
1.33
1.16
inr
0.79
26
246
8
23
3.55
2.29
1.3
1.3
—
—
—
0
0
69
501
1.51
2.17
2.8
2.3
2.40
3.00
mg/l
1.98
62
432
89
681
1.46
2.16
3.8
3.4
802.43
33.78
ng/l
0.48
56
416
6
15
4.07
2.05
1.8
1.9
—
—
—
0
0
47
317
1.59
2.05
4.3
2.7
3.11
2.56
e6/l
0.17
22
168
34
212
1.69
2.01
2.5
1.6
—
—
—
0
0
13
58
2.30
1.94
2.8
5.4
1.73
1.56
%
0.33
13
53
177
1553
1.41
1.92
11.0
7.1
81.01
78.28
u/l
0.36
169
1450
190
1692
1.43
1.86
4.0
3.4
—
—
—
0
0
122
1011
1.38
1.83
3.5
2.9
113.22
94.49
ug/l
0.20
115
941
5
12
4.22
1.83
1.2
1.8
63.80
68.83
umol/l
—
5
12
49
345
1.51
1.77
4.0
2.6
1.44
0.83
e6/l
0.58
25
194
123
1034
1.35
1.64
8.0
6.1
12.54
12.69
umol/l
0.03
115
972
33
216
1.60
1.64
2.4
1.6
—
—
—
0
0
52
377
1.47
1.64
1.5
1.3
41.86
29.52
iu/ml
0.22
16
127
149
1290
1.35
1.63
12.1
9.5
4.11
3.99
e9/l
0.24
132
1124
50
361
1.47
1.61
1.4
1.3
16.22
9.13
u/ml
0.19
19
158
59
441
1.43
1.59
3.5
2.0
1.16
1.08
mg/l
0.09
48
335
66
504
1.41
1.58
4.8
3.9
11.84
9.53
mg/mmol
0.20
44
326
5
15
3.38
1.53
8.6
1.6
2.36
2.93
mg/l
—
5
15
236
2217
1.56
1.51
19.4
12.0
25.60
21.83
mg/l
0.68
202
1681
213
1965
1.42
1.47
4.2
3.9
6.00
5.80
mmol/l
0.90
193
1806
45
324
1.47
1.47
5.5
3.3
94.95
218.70
ng/l
0.72
29
224
25
160
1.62
1.37
5.1
11.7
24.70
24.68
mmol/l
0.01
25
160
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
11
54
2.08
1.35
2.5
1.4
—
—
—
0
0
11
54
2.08
1.35
1.0
1.5
—
—
—
0
0
123
1057
1.30
1.34
5.0
4.6
0.00
0.00
estimate
-0.00
25
220
38
270
1.48
1.33
3.2
2.3
29.28
29.53
s
0.09
38
262
124
1069
1.30
1.31
3.3
3.4
0.00
0.00
estimate
-0.00
25
207
17
100
1.75
1.27
4.2
7.0
24.94
24.56
mmol/l
0.22
17
94
242
2304
1.54
1.24
13.8
9.4
27.26
25.92
u/l
0.64
235
2221
8
38
2.14
1.19
1.0
1.6
—
—
—
0
0
8
38
2.14
1.19
1.0
1.6
—
—
—
0
0
71
575
1.32
1.17
1.8
1.6
—
—
—
0
0
38
278
1.43
1.16
3.8
2.4
2.42
2.38
g/l
0.15
32
258
33
236
1.45
1.13
3.8
4.1
34.45
31.29
%
1.14
22
156
122
1064
1.27
1.13
3.3
3.3
0.00
0.00
estimate
-0.00
25
231
59
469
1.33
1.10
5.0
2.9
12715.78
7134.04
umol/l
0.27
49
410
28
195
1.49
1.10
4.5
8.4
4.99
5.09
kpa
0.33
28
187
28
195
1.49
1.10
4.5
8.4
13.25
13.05
kpa
0.08
28
187
8
41
1.98
1.09
1.0
1.4
—
—
—
0
0
58
461
1.33
1.08
2.6
2.5
—
—
—
0
0
183
1682
1.28
1.07
4.0
4.0
14.67
14.70
pmol/l
0.06
167
1520
28
196
1.48
1.07
2.6
2.6
45.83
29.11
u/l
0.42
23
169
15
235
0.62
1.02
1.7
1.6
—
—
—
0
0
23
157
1.51
1.00
4.3
5.7
0.89
1.26
mmol/l
0.18
17
114
5
23
2.20
0.98
3.2
1.6
0.26
0.19
e9/l
—
5
15
74
617
1.28
0.97
1.4
1.4
0.58
1.61
u/ml
1.68
16
158
6
27
2.25
0.94
1.0
1.7
—
—
—
0
0
10
55
1.85
0.93
1.0
1.5
—
—
—
0
0
6
28
2.17
0.92
1.0
1.5
—
—
—
0
0
6
28
2.17
0.92
1.0
1.5
—
—
—
0
0
34
256
1.38
0.90
3.9
2.6
27.39
24.62
%
0.31
22
224
6
29
2.09
0.90
1.0
1.5
—
—
—
0
0
16
103
1.59
0.89
1.4
1.6
—
—
—
0
0
22
153
1.48
0.89
3.3
2.7
74.38
73.24
ml/min/173m2
0.05
13
63
10
56
1.82
0.89
1.9
2.5
—
—
—
0
0
8
43
1.89
0.88
1.8
1.3
—
—
—
0
0
213
2021
1.27
0.80
4.9
4.6
1.82
1.86
mu/l
0.24
194
1847
0
26
0.00
0.79
0.0
3.7
—
78.30
—
0
26
16
107
1.53
0.78
1.4
1.3
208.11
298.54
miu/ml
—
9
53
53
437
1.27
0.77
2.5
2.2
—
—
—
0
0
10
59
1.72
0.77
1.5
1.3
198.80
315.22
ug/g
—
5
29
5
24
2.10
0.75
1.2
1.1
—
—
—
0
0
5
24
2.10
0.75
1.2
1.1
—
—
—
0
0
5
24
2.10
0.75
3.2
1.5
361.60
534.93
e6/l
—
5
15
9
56
1.63
0.73
1.9
1.4
—
—
—
0
0
7
40
1.77
0.72
1.0
1.1
—
—
—
0
0
7
40
1.77
0.72
1.0
1.4
—
—
—
0
0
5
26
1.94
0.71
1.0
1.7
—
—
—
0
0
5
26
1.94
0.71
1.0
1.7
—
—
—
0
0
5
26
1.94
0.71
1.0
1.7
—
—
—
0
0
5
27
1.87
0.69
1.0
1.6
—
—
—
0
0
5
27
1.87
0.69
1.0
1.7
—
—
—
0
0
5
28
1.80
0.66
1.8
2.2
—
—
—
0
0
10
62
1.64
0.66
1.9
1.3
—
—
—
0
0
5
30
1.68
0.61
1.2
1.3
—
—
—
0
0
8
51
1.59
0.61
1.1
1.3
—
—
—
0
0
14
97
1.47
0.60
1.3
1.6
—
—
—
0
0
255
2497
1.47
0.60
27.5
17.8
260.36
255.69
e9/l
0.45
250
2431
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
28
221
1.30
0.58
4.9
8.3
105.36
104.40
mmol/l
0.68
28
221
6
35
1.73
0.58
1.0
1.5
—
—
—
0
0
96
866
1.17
0.57
2.9
2.3
75.24
74.18
nmol/l
0.13
88
779
255
2499
1.45
0.57
27.0
18.0
39.67
40.31
%
0.81
228
2377
10
65
1.56
0.56
1.3
1.3
—
—
—
0
0
53
455
1.21
0.55
4.8
4.5
1.41
2.01
ug/l
1.55
48
408
255
2501
1.44
0.54
27.1
17.8
4.51
4.53
e12/l
0.19
250
2432
23
181
1.30
0.50
3.2
2.9
0.22
0.22
g/l
0.00
23
171
191
1826
1.16
0.49
5.8
5.1
40.32
39.24
mmol/mol
0.54
173
1706
168
1593
1.15
0.48
5.7
3.9
10.64
10.25
mm/h
0.13
159
1472
16
120
1.35
0.47
1.9
1.6
—
—
—
0
0
27
221
1.25
0.44
1.4
1.5
—
—
—
0
0
16
122
1.33
0.43
1.6
1.6
19.24
20.13
iu/l
0.05
16
99
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
2.2
—
—
—
0
0
13
97
1.36
0.40
1.6
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
33
282
1.19
0.37
1.8
1.9
—
—
—
0
0
16
126
1.29
0.36
1.6
1.5
—
—
—
0
0
15
119
1.28
0.32
1.5
1.4
—
—
—
0
0
15
119
1.28
0.32
1.5
1.4
—
—
—
0
0
15
119
1.28
0.32
1.5
1.4
—
—
—
0
0
15
120
1.26
0.31
1.5
1.4
—
—
—
0
0
7
55
1.28
0.30
2.7
2.0
—
—
—
0
0
18
148
1.23
0.30
1.1
1.0
—
—
—
0
0
27
232
1.18
0.30
7.2
6.9
—
—
—
0
0
18
149
1.22
0.28
2.2
2.4
26683.14
2878.97
u/l
—
7
65
10
76
1.33
0.28
1.2
1.8
—
266.67
—
0
6
8
64
1.26
0.27
8.9
2.4
—
—
—
0
0
8
65
1.24
0.27
1.5
1.3
—
9.58
—
0
11
36
320
1.14
0.27
2.0
1.7
1029.98
1203.93
nmol/l
0.58
31
245
63
581
1.11
0.27
2.9
3.4
0.00
0.00
estimate
-0.00
22
216
10
77
1.31
0.26
1.1
1.5
—
—
—
0
0
50
457
1.12
0.25
4.7
3.1
509.23
1202.77
ng/l
3.13
39
390
206
2012
1.10
0.25
21.1
14.6
14.57
14.47
%
0.10
206
1993
210
2053
1.11
0.25
4.7
4.3
2.80
2.78
mmol/l
0.09
190
1911
12
147
0.81
0.24
1.6
1.4
—
—
—
0
0
5
39
1.29
0.23
1.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
2.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
324.33
—
0
6
0
13
0.00
0.21
0.0
1.0
—
40.29
—
0
7
0
13
0.00
0.21
0.0
1.0
—
559.14
—
0
7
9
111
0.80
0.20
2.4
2.7
0.14
0.12
e6/l
—
9
105
206
2019
1.09
0.20
4.2
3.9
1.42
1.48
mmol/l
1.21
188
1881
6
48
1.26
0.20
1.2
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
11
91
1.22
0.18
1.4
1.3
—
—
—
0
0
25
225
1.12
0.17
1.6
1.9
—
—
—
0
0
16
139
1.16
0.16
9.4
4.3
92.44
74.11
ng/l
0.56
16
127
11
92
1.20
0.16
2.1
6.7
0.68
0.63
%
0.28
11
92
13
111
1.18
0.16
3.8
1.9
—
—
—
0
0
9
78
1.16
0.15
1.4
2.0
—
—
—
0
0
7
89
0.78
0.14
1.1
1.4
—
—
—
0
0
206
2029
1.07
0.14
4.3
3.9
4.69
4.67
mmol/l
0.13
189
1898
19
170
1.13
0.14
4.8
10.2
1.23
1.35
mmol/l
0.26
19
165
192
1951
0.94
0.13
14.0
10.8
89.13
88.16
ml/min/173m2
0.23
152
1550
24
262
0.91
0.13
2.8
2.7
0.70
0.75
ug/l
0.06
13
160
191
1939
0.95
0.12
3.8
3.5
1.35
1.26
mmol/l
0.82
173
1800
40
377
1.07
0.11
1.5
1.7
385.48
439.41
pmol/l
1.11
33
320
85
824
1.05
0.10
3.0
3.4
—
—
—
0
0
5
45
1.11
0.10
5.2
3.5
52.40
57.29
%
—
5
45
24
258
0.92
0.09
15.8
6.4
1.13
1.13
mmol/l
0.02
24
244
6
55
1.09
0.09
1.3
1.2
—
—
—
0
0
11
98
1.13
0.08
1.5
1.6
—
—
—
0
0
42
438
0.95
0.07
1.5
1.4
—
—
—
0
0
7
81
0.86
0.07
1.3
1.1
—
—
—
0
0
7
80
0.87
0.07
1.3
1.1
—
—
—
0
0
7
83
0.84
0.07
2.0
3.9
50.64
49.44
%
—
7
83
37
355
1.05
0.06
3.5
4.3
20.86
22.07
%
—
10
171
18
187
0.96
0.01
2.6
3.2
—
—
—
0
0
17
168
1.01
0.00
1.4
1.3
—
—
—
0
0
11
107
1.03
0.00
1.2
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
103.66
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
13.57
—
0
6
8
88
0.91
-0.00
1.5
1.5
—
—
—
0
0
7
75
0.93
-0.00
1.4
1.5
44.14
40.07
nmol/l
—
7
75
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
67.44
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
6.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_MYRINGACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MYRINGACU | 1.323 [0.97, 1.81] | 0.079 |
| Birth year | 0.995 [0.99, 1.0] | 0.313 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 1464 females with H8_MYRINGACU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MYRINGACU | 1.3 [0.92, 1.83] | 0.133 |
| Birth year | 0.99 [0.98, 1.0] | 0.04 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1363 males with H8_MYRINGACU died.
Mortality risk
Mortality risk for people of age
years, who have H8_MYRINGACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.129% | 0.354% |
| 5 | 0.737% | 1.732% |
| 10 | 2.045% | 4.315% |
| 15 | 4.011% | 8.126% |
| 20 | 6.719% | 13.886% |
Relationships between endpoints
↥Index endpoint: H8_MYRINGACU – Acute myringitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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