No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
255 |
4. Check minimum number of eventsNone |
255 |
5. Include endpointsNone |
255 |
6. Filter based on genotype QC (FinnGen only) |
255 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H73
- Name in latin
- Myringitis acuta
Similar endpoints
↥List of similar endpoints to
Acute myringitis
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3427 | 1705 | 1712 |
| Only index persons | 2624 | 1359 | 1265 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 11.72 | 13.87 | 9.40 |
| Only index persons | 19.24 | 21.74 | 16.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 255 | 165 | 90 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 40.44 | 37.30 | 46.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 230
- Matched controls
- 2301
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H73.0
ICD-10 Finland
Acute myringitis
4853.5
284.3
216
7
H66.0
ICD-10 Finland
Acute suppurative otitis media
18.7
48.0
77
60
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
37.5
35
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
57.2
25.9
30
6
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
97.3
24.2
26
*
UDC00
NOMESCO Finland
Ear microscopy
9.6
23.1
49
63
H65.3
ICD-10 Finland
Chronic mucoid otitis media
242.1
22.0
22
*
H66.9
ICD-10 Finland
Otitis media, unspecified
8.3
18.4
42
60
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
16.9
16
*
3840A
ICD-9 Finland
Other disorders of tympanic membrane, Acute myringitis without mention of otitis media
+∞
14.7
14
*
H65.0
ICD-10 Finland
Acute serous otitis media
32.3
14.1
18
6
DCD00
NOMESCO Finland
Myringoplasty
+∞
13.7
13
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
12.6
12
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.6
11.4
142
872
DC1AD
NOMESCO Finland
Temporalbone CT
34.3
10.4
13
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.6
9.5
82
398
4122
FHL
Tympanostomy (tympanic tube)
104.1
9.5
10
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
5.2
9.4
29
62
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
9.4
9
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
9.4
9
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
8.4
8
*
DFF00
NOMESCO Finland
Pure tone audiometry
4.3
8.4
31
81
S02CA02
ATC
flumetasone and antiinfectives; otic
5.7
8.3
23
44
H92.0
ICD-10 Finland
Otalgia
5.1
8.1
25
54
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
46.6
7.8
9
*
H01
ICPC
Ear pain/earache
3.2
7.6
42
152
J01CA04
ATC
amoxicillin; systemic
2.8
7.3
202
1655
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.9
7.2
47
188
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.9
6.9
45
180
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
17.3
6.8
10
6
M54.4
ICD-10 Finland
Lumbago with sciatica
2.9
6.7
42
165
H60.3
ICD-10 Finland
Other infective otitis externa
10.5
6.6
12
12
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
+∞
6.3
6
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
27.5
6.3
8
*
TDA90
NOMESCO Finland
Removal wax from ear
13.0
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
285
1.94
3.94
2.2
1.7
—
—
—
0
0
114
834
1.66
3.83
6.8
6.8
1.2
1.2
mmol/l
0.94
104
761
146
1159
1.61
3.39
5.2
5.0
6.5
6.6
mmol/l
0.11
137
1052
85
596
1.64
3.27
3.3
2.4
63.5
56.2
u/l
0.23
75
553
94
676
1.62
3.27
3.9
3.1
—
—
—
0
0
96
694
1.61
3.26
2.1
1.8
99.7
95.1
pmol/l
0.56
61
362
124
956
1.58
3.20
5.0
4.0
—
—
—
0
0
76
529
1.62
2.97
4.1
3.0
0.4
0.4
e6/l
0.02
55
393
8
17
4.82
2.94
1.4
1.7
13.0
13.2
%
—
8
17
26
132
2.08
2.82
1.7
1.5
—
—
—
0
0
12
42
2.95
2.79
1.2
1.5
—
—
—
0
0
169
1431
1.54
2.65
3.5
3.0
40.4
41.7
u/l
0.13
157
1361
103
788
1.52
2.62
7.5
4.8
36.6
36.2
g/l
0.22
98
741
67
474
1.56
2.40
2.8
2.4
2.4
3.0
mg/l
2.20
61
411
34
201
1.80
2.40
2.5
1.6
—
—
—
0
0
115
913
1.47
2.38
9.0
7.3
1.2
1.2
mmol/l
0.73
101
780
8
23
3.56
2.29
1.3
1.2
—
—
—
0
0
87
659
1.49
2.26
3.8
3.4
802.4
33.7
ng/l
0.48
56
406
173
1500
1.48
2.20
11.1
7.1
81.6
78.6
u/l
0.40
163
1400
15
68
2.28
2.15
1.7
1.8
—
—
—
0
0
14
62
2.33
2.12
1.5
1.6
—
—
—
0
0
6
15
4.07
2.05
1.8
1.9
—
—
—
0
0
33
205
1.70
1.98
2.4
1.6
—
—
—
0
0
10
39
2.63
1.94
1.0
1.2
3.4
2.7
u/ml
—
5
18
117
965
1.39
1.84
3.6
2.8
117.3
95.1
ug/l
0.24
111
897
145
1240
1.39
1.84
12.3
9.6
4.1
4.0
e9/l
0.35
129
1077
5
12
4.23
1.83
1.4
1.2
214.0
79.2
u/l
—
5
6
51
361
1.52
1.81
1.5
1.3
44.0
29.3
iu/ml
0.25
15
119
44
305
1.53
1.72
4.2
2.8
3.4
2.6
e6/l
0.26
20
164
119
996
1.37
1.67
8.2
6.2
12.5
12.8
umol/l
0.04
111
938
179
1600
1.40
1.65
4.1
3.4
—
—
—
0
0
64
483
1.43
1.65
3.4
2.2
—
—
—
0
0
44
308
1.52
1.65
5.6
3.3
98.3
195.0
ng/l
0.50
28
213
5
15
3.38
1.53
8.6
1.6
2.4
2.9
mg/l
—
5
15
46
332
1.47
1.49
4.0
2.7
1.4
0.8
e6/l
0.51
23
189
48
350
1.46
1.48
1.4
1.3
17.0
9.3
u/ml
0.19
18
152
11
53
2.12
1.40
1.0
1.5
—
—
—
0
0
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
178
1613
1.34
1.35
4.2
4.0
14.7
14.7
pmol/l
0.03
163
1459
56
429
1.39
1.32
3.4
2.0
1.2
1.1
mg/l
0.11
45
326
36
254
1.49
1.31
3.0
2.3
29.4
29.6
s
0.07
36
246
28
187
1.56
1.30
2.6
2.5
45.8
29.4
u/l
0.41
23
162
215
2012
1.44
1.30
20.4
13.4
38.9
40.1
%
1.05
145
1594
73
588
1.34
1.26
1.4
1.4
0.6
1.7
u/ml
1.69
16
152
10
49
2.08
1.23
2.7
1.4
—
—
—
0
0
37
267
1.45
1.21
3.8
2.4
2.4
2.4
g/l
0.18
31
247
224
2120
1.47
1.19
20.1
12.1
26.1
21.9
mg/l
0.77
192
1597
8
40
2.03
1.13
1.0
1.5
—
—
—
0
0
57
452
1.34
1.09
5.2
2.9
12715.8
7464.6
umol/l
0.25
49
391
202
1889
1.33
1.07
4.3
4.0
6.0
5.8
mmol/l
1.04
183
1735
14
225
0.60
1.05
1.8
1.6
—
—
—
0
0
5
22
2.30
1.04
1.2
1.1
—
—
—
0
0
231
2211
1.48
1.02
14.1
9.4
27.3
25.8
u/l
0.69
224
2134
9
48
1.91
1.01
1.9
1.4
—
—
—
0
0
31
225
1.43
1.00
3.9
4.1
35.1
31.4
%
1.55
21
147
5
23
2.20
0.98
1.2
1.2
—
—
—
0
0
5
23
2.20
0.98
3.2
1.6
0.3
0.2
e9/l
—
5
15
5
23
2.20
0.98
1.0
1.4
391.2
299.9
pmol/l
—
5
18
10
54
1.89
0.98
1.0
1.5
—
—
—
0
0
115
1012
1.25
0.97
5.2
4.7
0.0
0.0
estimate
0.00
26
206
33
245
1.40
0.95
4.0
2.5
27.3
24.6
%
0.29
21
213
6
27
2.25
0.94
1.0
1.7
—
—
—
0
0
116
1025
1.24
0.94
3.5
3.4
0.0
0.0
estimate
0.00
26
195
6
28
2.17
0.92
1.0
1.5
—
—
—
0
0
72
605
1.26
0.90
4.9
3.1
2.3
2.4
mmol/l
0.51
67
538
10
56
1.82
0.89
1.9
2.5
—
—
—
0
0
204
1927
1.29
0.88
5.1
4.7
1.8
1.9
mu/l
0.29
186
1759
26
188
1.43
0.87
4.4
8.3
0.9
1.1
mmol/l
0.07
21
150
22
154
1.47
0.87
5.0
12.0
24.5
24.7
mmol/l
0.09
22
154
21
146
1.48
0.85
3.4
2.8
72.5
72.4
ml/min/173m2
0.00
12
61
65
544
1.26
0.84
1.8
1.6
—
—
—
0
0
51
415
1.29
0.82
2.6
2.5
—
—
—
0
0
0
24
0.00
0.79
0.0
3.9
—
84.0
—
0
24
95
834
1.22
0.79
2.9
2.3
75.8
74.4
nmol/l
0.17
87
751
21
149
1.45
0.78
4.3
5.8
0.8
1.3
mmol/l
0.24
16
108
15
99
1.55
0.77
1.4
1.6
—
—
—
0
0
10
59
1.72
0.77
1.9
1.3
—
—
—
0
0
6
34
1.78
0.77
1.0
1.5
—
—
—
0
0
25
185
1.39
0.75
4.3
8.3
12.8
13.0
kpa
0.07
25
177
25
185
1.39
0.75
4.3
8.3
5.0
5.1
kpa
0.20
25
177
113
1014
1.21
0.75
3.4
3.3
0.0
0.0
estimate
0.00
24
204
5
24
2.10
0.75
3.2
1.5
361.6
534.9
e6/l
—
5
15
7
38
1.87
0.74
1.0
1.4
—
—
—
0
0
7
40
1.77
0.72
1.4
1.3
—
—
—
0
0
5
26
1.94
0.71
1.0
1.7
—
—
—
0
0
5
26
1.94
0.71
1.0
1.7
—
—
—
0
0
5
26
1.94
0.71
1.0
1.7
—
—
—
0
0
15
102
1.50
0.69
1.5
1.4
208.1
289.3
miu/ml
—
9
49
5
27
1.87
0.69
1.0
1.7
—
—
—
0
0
5
27
1.87
0.69
1.0
1.6
—
—
—
0
0
5
28
1.80
0.66
1.0
1.1
—
—
—
0
0
5
30
1.68
0.61
1.2
1.3
—
—
—
0
0
162
1519
1.18
0.61
5.7
4.0
10.9
10.2
mm/h
0.25
154
1405
8
51
1.59
0.61
1.1
1.3
—
—
—
0
0
10
64
1.59
0.59
1.3
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
23
177
1.33
0.57
3.2
2.9
0.2
0.2
g/l
0.02
23
167
185
1760
1.19
0.56
5.9
5.1
40.5
39.3
mmol/mol
0.64
168
1646
6
38
1.59
0.54
1.0
1.1
—
—
—
0
0
26
206
1.29
0.53
4.3
6.0
0.7
1.6
mmol/l
0.75
21
163
46
391
1.22
0.53
2.6
2.3
—
—
—
0
0
13
93
1.42
0.49
1.2
1.7
—
—
—
0
0
25
202
1.26
0.45
1.4
1.5
—
—
—
0
0
13
95
1.39
0.44
1.6
1.3
—
—
—
0
0
8
58
1.39
0.42
8.9
2.5
—
—
—
0
0
31
260
1.22
0.42
1.7
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
18
142
1.29
0.39
1.1
1.0
—
—
—
0
0
10
136
0.72
0.38
1.4
1.4
—
—
—
0
0
6
46
1.31
0.33
1.2
1.6
—
—
—
0
0
14
110
1.29
0.32
1.8
1.6
—
—
—
0
0
14
110
1.29
0.32
1.5
1.4
—
—
—
0
0
14
110
1.29
0.32
1.5
1.4
—
—
—
0
0
14
110
1.29
0.32
1.5
1.4
—
—
—
0
0
192
1863
1.12
0.31
21.9
15.0
13.7
13.5
%
0.52
192
1844
7
52
1.36
0.31
2.7
2.0
—
—
—
0
0
15
120
1.27
0.31
1.6
1.6
20.1
20.5
iu/l
0.02
15
97
14
111
1.28
0.30
1.5
1.4
—
—
—
0
0
10
75
1.35
0.30
1.2
1.8
—
266.7
—
0
6
8
108
0.73
0.29
2.6
2.7
0.0
0.1
e6/l
—
8
102
8
62
1.30
0.28
1.5
1.3
—
9.6
—
0
11
41
367
1.14
0.28
1.5
1.7
385.5
441.8
pmol/l
1.17
33
311
16
131
1.24
0.28
9.4
4.2
92.4
72.6
ng/l
0.62
16
120
35
310
1.15
0.28
2.1
1.7
1046.2
1202.4
nmol/l
0.49
30
237
26
226
1.17
0.26
7.3
6.9
—
—
—
0
0
9
72
1.26
0.26
1.4
2.1
—
—
—
0
0
9
73
1.24
0.25
1.1
1.5
—
—
—
0
0
14
115
1.23
0.24
1.6
1.5
—
—
—
0
0
199
1946
1.10
0.23
4.2
3.9
1.4
1.5
mmol/l
0.95
181
1807
5
39
1.29
0.23
1.0
1.6
—
—
—
0
0
16
135
1.20
0.22
2.3
2.5
23167.6
3178.9
u/l
—
5
58
0
11
0.00
0.21
0.0
1.1
—
44.3
—
0
6
0
11
0.00
0.21
0.0
1.2
—
324.3
—
0
6
0
11
0.00
0.21
0.0
1.0
—
516.5
—
0
6
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.5
—
—
—
0
0
11
89
1.25
0.21
1.4
1.3
—
—
—
0
0
11
89
1.25
0.21
2.0
1.6
—
—
—
0
0
60
560
1.09
0.21
3.0
3.5
0.0
0.0
estimate
0.00
23
203
202
1980
1.10
0.21
4.7
4.3
2.8
2.8
mmol/l
0.44
182
1834
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
0
14
0.00
0.20
0.0
2.1
—
—
—
0
0
22
249
0.87
0.20
2.5
2.7
0.7
0.7
ug/l
0.05
12
152
6
52
1.16
0.19
1.3
1.2
—
—
—
0
0
48
446
1.09
0.18
4.8
3.0
520.7
1182.9
ng/l
2.82
38
381
23
206
1.13
0.16
1.6
1.9
—
—
—
0
0
199
1956
1.08
0.16
4.3
4.0
4.7
4.7
mmol/l
0.46
182
1825
14
161
0.86
0.15
5.0
10.2
1.1
1.4
mmol/l
0.67
14
152
39
419
0.92
0.15
1.6
1.5
—
—
—
0
0
184
1870
0.94
0.13
3.8
3.5
1.3
1.3
mmol/l
0.80
167
1734
12
104
1.16
0.12
4.0
1.8
—
—
—
0
0
11
96
1.15
0.10
1.2
1.7
—
—
—
0
0
82
794
1.05
0.10
3.1
3.4
—
—
—
0
0
6
73
0.82
0.07
1.5
1.5
31.8
39.9
nmol/l
—
6
73
7
81
0.86
0.07
2.0
4.0
50.6
48.4
%
—
7
81
7
85
0.82
0.07
1.1
1.4
—
—
—
0
0
185
1866
0.97
0.05
14.2
10.8
88.9
87.7
ml/min/173m2
0.31
147
1484
35
339
1.04
0.03
3.3
4.3
21.0
21.7
%
—
9
162
16
153
1.05
0.01
1.4
1.3
—
—
—
0
0
19
183
1.04
0.01
2.5
3.3
—
—
—
0
0
7
73
0.96
0.00
1.3
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
0.00
1.6
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
7
72
0.97
0.00
1.3
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
1.2
1.7
1920.6
226.8
e6/l
—
5
40
0
6
0.00
0.00
0.0
2.7
—
115.4
—
0
6
0
6
0.00
0.00
0.0
6.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
67.4
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
93
0.97
0.00
6.1
10.8
24.2
24.6
mmol/l
—
9
88
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_MYRINGACU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MYRINGACU | 1.323 [0.97, 1.81] | 0.079 |
| Birth year | 0.995 [0.99, 1.0] | 0.313 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 1464 females with H8_MYRINGACU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MYRINGACU | 1.3 [0.92, 1.83] | 0.133 |
| Birth year | 0.99 [0.98, 1.0] | 0.04 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 1363 males with H8_MYRINGACU died.
Mortality risk
Mortality risk for people of age
years, who have H8_MYRINGACU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.129% | 0.354% |
| 5 | 0.737% | 1.732% |
| 10 | 2.045% | 4.315% |
| 15 | 4.011% | 8.126% |
| 20 | 6.719% | 13.886% |
Relationships between endpoints
↥Index endpoint: H8_MYRINGACU – Acute myringitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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