alcoholic cardiomyopathy: Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
170 |
4. Check minimum number of eventsNone |
170 |
5. Include endpointsNone |
170 |
6. Filter based on genotype QC (FinnGen only) |
170 |
Control definitions (FinnGen only)
- Control exclude
- I9_CARDMYO
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I42
- Name in latin
- Cardiomyopathia alcoholica
Similar endpoints
↥List of similar endpoints to
Alcoholic cardiomyopathy
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Other heart diseases, wide
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5527 | 579 | 4785 |
| Only index persons | 1818 | 218 | 1600 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.02 | 0.13 |
| Only index persons | 0.05 | 0.01 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 54.66 | 56.03 | 54.42 |
| Only index persons | 58.18 | 59.42 | 58.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 170 | 16 | 154 |
| Unadjusted period prevalence (%) | 0.06 | 0.01 | 0.07 |
| Median age at first event (years) | 61.18 | 53.35 | 61.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 152
- Matched controls
- 1521
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I42.6
ICD-10 Finland
Alcoholic cardiomyopathy
+∞
168.9
129
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
60.5
54
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
20.2
34.2
53
39
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
26.9
25
*
4255A
ICD-9 Finland
Cardiomyopathy, Alcoholic cardiomyopathy
+∞
26.9
25
*
C01AA05
ATC
digoxin; systemic
8.7
22.8
54
90
C03DA01
ATC
spironolactone; oral
8.7
21.3
50
81
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.4
20.8
46
67
K70.0
ICD-10 Finland
Alcoholic fatty liver
45.6
16.8
20
5
I50.9
ICD-10 Finland
Heart failure, unspecified
4.9
15.4
59
173
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
14.0
14.7
25
21
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
17.9
12.5
19
12
C09DX04
ATC
valsartan and sacubitril; oral
70.5
11.8
13
*
A98
ICPC
Health maint/preventive medicine
0.3
11.7
71
1140
C03CA01
ATC
furosemide; systemic
3.4
11.6
82
390
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
18.9
11.5
17
10
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
17.2
11.1
17
11
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
64.7
10.8
12
*
N07BB01
ATC
disulfiram; oral
9.0
10.6
22
28
I50.1
ICD-10 Finland
Left ventricular failure
7.7
10.4
24
36
P15
ICPC
Chronic alcohol abuse
10.7
10.1
19
20
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
58.9
9.8
11
*
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
19.1
9.6
14
8
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
19.1
9.6
14
8
N05BA02
ATC
chlordiazepoxide; systemic
11.8
9.0
16
15
F10.20
ICD-10 Finland
Alcohol dependence currently independent
11.8
9.0
16
15
I50.0
ICD-10 Finland
Congestive heart failure
4.6
8.7
31
80
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
13.9
8.6
14
11
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
15.6
8.4
13
9
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
9.0
8.3
17
21
F10.25
ICD-10 Finland
Alcohol dependence continuous use
11.0
8.2
15
15
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
23.5
8.1
11
5
C01BD01
ATC
amiodarone; systemic
14.1
8.0
13
10
F10.24
ICD-10 Finland
Alcohol depence active use
14.1
8.0
13
10
N05AA02
ATC
levomepromazine; systemic
6.2
7.7
20
36
K70.4
ICD-10 Finland
Alcoholic hepatic failure
84.0
7.5
8
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.9
7.4
20
38
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
9.5
7.2
14
16
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
10.8
7.2
13
13
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
0.3
7.2
20
507
XF400
NOMESCO Finland
ECG with 12 standard connections
3.1
6.8
41
164
F10.09
ICD-10 Finland
Alcohol intoxication UNS
8.8
6.5
13
16
1CX08
NOMESCO Finland
NA
+∞
6.3
6
*
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
+∞
6.3
6
*
4254A
ICD-9 Finland
Cardiomyopathy, Other primary cardiomyopathies
+∞
6.3
6
*
4259X
ICD-9 Finland
Cardiomyopathy, Secondary cardiomyopathy, unspecified
+∞
6.3
6
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.2
6.3
13
17
T36
ICD-10 Finland
Poisoning by systemic antibiotics
6.5
6.2
15
25
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOALC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOALC | 8.396 [6.95, 10.14] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 408 out of 630 males with I9_CARDMYOALC died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOALC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 1.353% |
| 5 | No data | 8.938% |
| 10 | No data | 20.736% |
| 15 | No data | 36.196% |
| 20 | No data | 53.948% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOALC – Alcoholic cardiomyopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data