alcoholic cardiomyopathy: Disease of CARDIAC MUSCLE resulting from chronic excessive alcohol consumption. Myocardial damage can be caused by: (1) a toxic effect of alcohol; (2) malnutrition in alcoholics such as THIAMINE DEFICIENCY; or (3) toxic effect of additives in alcoholic beverages such as COBALT. This disease is usually manifested by DYSPNEA and palpitations with CARDIOMEGALY and congestive heart failure (HEART FAILURE).
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
193 |
4. Check minimum number of eventsNone |
193 |
5. Include endpointsNone |
193 |
6. Filter based on genotype QC (FinnGen only) |
189 |
Control definitions (FinnGen only)
- Control exclude
- I9_CARDMYO
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I42
- Name in latin
- Cardiomyopathia alcoholica
Similar endpoints
↥List of similar endpoints to
Alcoholic cardiomyopathy
based on the number of shared cases.
Similar with more cases:
- Cardiomyopathy
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Other heart diseases, wide
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5527 | 579 | 4785 |
| Only index persons | 1818 | 218 | 1600 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.02 | 0.13 |
| Only index persons | 0.05 | 0.01 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 54.66 | 56.03 | 54.42 |
| Only index persons | 58.18 | 59.42 | 58.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 189 | 19 | 170 |
| Unadjusted period prevalence (%) | 0.07 | 0.01 | 0.08 |
| Median age at first event (years) | 61.02 | 54.85 | 61.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 193
- Matched controls
- 1930
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I42.6
ICD-10 Finland
Alcoholic cardiomyopathy
+∞
224.2
169
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
70.2
63
*
201
Kela drug reimbursment
Chronic cardiac insufficiency
17.6
68.8
65
54
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
10.4
48.8
67
94
C01AA05
ATC
digoxin; systemic
8.3
37.5
60
99
C03DA01
ATC
spironolactone; oral
7.4
35.4
65
124
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
12.6
30.4
32
30
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
30.0
28
*
4255A
ICD-9 Finland
Cardiomyopathy, Alcoholic cardiomyopathy
+∞
27.8
26
*
I50.9
ICD-10 Finland
Heart failure, unspecified
5.0
24.9
73
208
P15
ICPC
Chronic alcohol abuse
10.0
24.3
30
35
K70.0
ICD-10 Finland
Alcoholic fatty liver
49.7
22.0
26
6
F10.25
ICD-10 Finland
Alcohol dependence continuous use
20.7
18.4
27
15
N07BB01
ATC
disulfiram; oral
6.8
18.1
31
53
N05AA02
ATC
levomepromazine; systemic
8.0
16.0
23
32
I50.1
ICD-10 Finland
Left ventricular failure
6.0
15.9
31
60
C03CA01
ATC
furosemide; systemic
3.4
15.6
99
459
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
27.7
15.0
20
8
I50.0
ICD-10 Finland
Congestive heart failure
4.9
14.9
37
89
A98
ICPC
Health maint/preventive medicine
0.3
14.8
108
1562
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
18.9
14.7
22
13
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
24.6
14.6
20
9
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
17.6
14.3
22
14
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
22.1
14.1
20
10
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
17.9
13.8
21
13
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
14.6
12.8
21
16
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
74.9
12.8
14
*
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
20.5
11.8
17
9
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
69.3
11.8
13
*
F10.24
ICD-10 Finland
Alcohol depence active use
14.9
11.7
19
14
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
14.9
11.7
19
14
C09DX04
ATC
valsartan and sacubitril; oral
46.1
11.1
13
*
F10.20
ICD-10 Finland
Alcohol dependence currently independent
11.0
10.8
20
20
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
17.9
10.0
15
9
N05BA02
ATC
chlordiazepoxide; systemic
11.5
10.0
18
17
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.9
9.6
22
49
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
9.4
51
207
F10.09
ICD-10 Finland
Alcohol intoxication UNS
9.0
9.3
19
23
N05CD07
ATC
temazepam; oral
3.3
9.1
39
137
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
10.2
9.0
17
18
N05BA01
ATC
diazepam; systemic, rectal
3.3
8.9
39
139
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.9
8.8
18
22
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
12.4
8.7
15
13
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.6
8.7
70
347
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
8.6
51
216
S82.6
ICD-10 Finland
Fracture of lateral malleolus
5.3
8.5
18
37
K70.4
ICD-10 Finland
Alcoholic hepatic failure
94.0
8.5
9
*
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
26.2
7.6
10
*
1CX08, ,
NOMESCO Finland
83.2
7.5
8
*
207
Kela drug reimbursment
Chronic arrhythmias
2.7
7.3
46
200
K70.1
ICD-10 Finland
Alcoholic hepatitis
31.3
7.2
9
*
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
12.7
7.2
12
10
N05BA04
ATC
oxazepam; oral
2.5
7.1
55
265
B01AA03
ATC
warfarin; systemic
2.4
6.7
57
285
Z72.1
ICD-10 Finland
Alcohol use
12.9
6.7
11
9
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
10.6
6.6
12
12
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
6.6
51
244
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.2
6.6
5
271
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
6.3
6
*
4254A
ICD-9 Finland
Cardiomyopathy, Other primary cardiomyopathies
+∞
6.3
6
*
4259X
ICD-9 Finland
Cardiomyopathy, Secondary cardiomyopathy, unspecified
+∞
6.3
6
*
I42.8
ICD-10 Finland
Other cardiomyopathies
+∞
6.3
6
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.3
6.0
24
80
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
108
1597
0.26
17.97
53.2
22.2
39.39
40.79
%
1.24
101
1501
107
1547
0.31
14.21
40.9
18.2
88.52
86.24
umol/l
0.22
107
1547
97
1462
0.32
13.39
5.1
5.2
2.48
2.68
mmol/l
1.46
89
1347
92
1417
0.33
13.00
4.6
4.6
1.27
1.33
mmol/l
0.67
83
1306
93
1421
0.33
12.76
4.6
4.7
4.35
4.48
mmol/l
0.52
84
1318
97
1423
0.36
11.01
4.9
4.7
6.52
6.13
mmol/l
1.10
86
1307
48
174
3.34
10.80
3.7
1.9
2.20
1.70
%
1.14
43
150
94
1394
0.37
10.75
4.4
4.2
1.64
1.35
mmol/l
2.28
85
1281
57
1055
0.35
10.35
4.0
4.7
2.17
2.60
ug/l
0.41
50
949
95
1382
0.38
9.70
35.2
14.2
82.17
78.92
ml/min/173m2
0.56
83
1150
103
1440
0.39
9.33
38.0
15.5
31.90
26.51
mg/l
1.00
94
1186
95
1372
0.39
9.21
6.0
6.1
42.18
40.87
mmol/mol
0.44
86
1288
34
118
3.28
8.08
3.1
2.7
29.86
36.84
u/l
0.46
29
101
45
843
0.39
7.16
3.8
4.1
19.18
21.15
%
0.56
20
408
37
151
2.79
6.60
5.8
4.0
2.97
1.44
mmol/l
1.47
29
120
37
153
2.75
6.43
5.9
4.0
5.72
5.73
kpa
0.01
37
147
92
1253
0.49
5.51
4.2
3.8
1.89
1.98
mu/l
0.39
85
1117
30
128
2.59
4.87
5.4
3.0
5.06
4.47
kpa
0.32
30
121
46
768
0.47
4.71
3.3
2.5
—
—
—
0
0
12
29
4.34
3.77
1.3
1.3
—
—
—
0
0
12
29
4.34
3.77
1.3
1.3
—
—
—
0
0
36
608
0.50
3.53
2.2
3.0
0.57
0.78
ug/l
1.40
29
406
6
8
7.69
3.07
1.0
1.5
95.17
89.13
%
—
6
8
79
1037
0.60
3.04
3.5
4.0
17.63
12.42
mm/h
1.59
73
953
28
143
2.12
3.04
21.2
7.1
13.70
10.30
mmol/l
0.85
28
138
33
183
1.97
2.88
2.1
1.8
—
—
—
0
0
35
563
0.54
2.81
5.7
3.7
—
—
—
0
0
49
716
0.58
2.79
4.7
3.5
0.00
0.00
estimate
—
9
122
33
187
1.92
2.71
2.2
1.9
—
—
—
0
0
34
196
1.89
2.65
22.4
7.8
0.72
1.00
mmol/l
0.08
29
155
30
167
1.94
2.59
3.3
3.2
19.68
11.39
umol/l
0.47
25
150
21
102
2.19
2.58
1.6
1.4
—
—
—
0
0
5
160
0.29
2.56
3.2
4.2
2.90
88.63
ug/l
—
5
138
49
702
0.60
2.52
4.6
3.5
0.00
0.01
estimate
—
9
146
49
698
0.60
2.44
5.1
4.8
0.00
0.00
estimate
—
9
134
8
195
0.38
2.33
3.5
2.2
6.90
13.52
nmol/l
—
8
177
38
257
1.60
1.70
2.4
1.9
—
—
—
0
0
10
41
2.52
1.67
1.2
1.4
—
—
—
0
0
26
394
0.61
1.57
6.5
3.6
0.00
0.00
estimate
—
9
124
9
44
2.10
1.28
1.4
1.3
—
—
—
0
0
6
25
2.44
1.25
1.0
1.2
327.00
268.29
u/ml
—
6
14
8
151
0.51
1.20
2.4
1.3
—
—
—
0
0
6
26
2.35
1.19
1.0
1.2
—
—
—
0
0
10
183
0.52
1.19
29.6
8.7
—
—
—
0
0
0
33
0.00
1.17
0.0
1.1
—
—
—
0
0
0
35
0.00
1.16
0.0
1.5
—
—
—
0
0
52
650
0.73
1.16
8.2
3.9
32.31
48.07
ng/l
1.02
43
492
0
36
0.00
1.15
0.0
1.3
—
—
—
0
0
22
317
0.65
1.06
2.3
1.7
454.56
429.96
pmol/l
0.15
16
265
23
156
1.54
1.04
4.8
2.6
7.97
8.63
ug/l
0.05
23
139
17
108
1.63
1.00
1.7
1.6
—
—
—
0
0
55
444
1.33
0.98
3.1
3.0
1.40
0.43
e6/l
0.85
46
339
5
23
2.20
0.98
3.8
3.9
—
—
—
0
0
13
77
1.74
0.98
1.9
2.0
5.48
2.59
ug/l
0.34
13
69
0
31
0.00
0.97
0.0
1.3
—
—
—
0
0
6
27
2.26
0.94
1.5
2.6
139.00
128.11
g/l
—
6
18
14
88
1.64
0.87
1.7
1.7
—
—
—
0
0
35
271
1.36
0.82
2.8
2.7
1.94
1.06
e6/l
0.35
27
172
6
33
1.84
0.79
1.2
1.5
—
—
—
0
0
12
76
1.62
0.73
1.5
1.5
1.35
1.46
g/l
0.23
12
70
38
304
1.31
0.73
10.6
1.8
1.50
1.55
mg/l
0.05
29
243
10
61
1.67
0.70
2.0
3.5
—
—
—
0
0
42
502
0.79
0.64
3.3
3.8
22.91
8.89
mg/mmol
0.62
33
328
57
657
0.81
0.63
3.7
2.7
—
—
—
0
0
24
185
1.34
0.59
16.9
4.2
239.33
241.27
u/l
0.03
24
174
0
23
0.00
0.58
0.0
4.0
—
1096.17
—
0
6
6
36
1.69
0.57
2.2
1.3
—
—
—
0
0
6
36
1.69
0.57
2.2
1.3
—
—
—
0
0
6
36
1.69
0.57
1.3
1.6
—
—
—
0
0
9
59
1.55
0.56
1.0
3.2
—
1.38
—
0
8
6
40
1.52
0.52
1.3
1.5
—
—
—
0
0
75
826
0.85
0.48
7.0
9.3
4.78
4.30
e9/l
0.91
68
715
31
258
1.24
0.45
2.9
3.0
1.37
0.61
e6/l
0.31
23
159
7
50
1.41
0.45
2.1
1.4
—
—
—
0
0
84
769
1.16
0.44
34.7
13.3
1.34
1.32
inr
0.05
16
220
5
32
1.58
0.42
1.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
16
196
0.80
0.31
1.2
1.2
30.65
37.29
iu/ml
—
6
61
9
116
0.76
0.28
5.3
3.0
5.37
5.06
kpa
—
9
111
62
572
1.12
0.28
3.4
3.1
—
—
—
0
0
8
64
1.26
0.28
1.4
2.7
—
—
—
0
0
74
692
1.11
0.26
15.2
7.2
1.16
1.20
mmol/l
2.72
62
586
0
11
0.00
0.21
0.0
3.4
—
—
—
0
0
0
11
0.00
0.21
0.0
3.3
—
16.27
—
0
11
0
11
0.00
0.21
0.0
1.3
—
9.25
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
491.20
—
0
5
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
36.20
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.17
0.21
1.2
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
8.9
—
120.50
—
0
6
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
19
166
1.16
0.19
5.8
3.5
—
—
—
0
0
37
341
1.11
0.17
4.1
2.4
—
—
—
0
0
11
130
0.84
0.16
2.1
2.0
426.36
350.97
nmol/l
1.06
11
116
10
116
0.85
0.12
3.0
3.7
1.17
1.22
mmol/l
—
10
104
5
48
1.04
0.09
1.8
1.6
—
—
—
0
0
43
446
0.95
0.06
2.6
3.3
2.33
2.33
mmol/l
0.01
35
393
29
291
1.00
0.00
2.1
1.7
1398.49
1202.88
nmol/l
0.35
24
226
58
575
1.01
0.00
2.1
2.0
77.85
91.69
pmol/l
1.60
38
322
26
262
0.99
0.00
2.9
3.1
2.50
2.44
mmol/l
1.35
20
226
5
55
0.91
0.00
5.0
4.0
4.66
4.74
pmol/l
—
5
50
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.4
—
89.57
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
13.13
—
0
8
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
50.66
—
0
5
5
49
1.02
-0.00
1.8
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.7
—
169.45
—
0
6
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1501.60
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
107.60
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
1079.57
—
0
7
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_CARDMYOALC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_CARDMYOALC | 8.396 [6.95, 10.14] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 408 out of 630 males with I9_CARDMYOALC died.
Mortality risk
Mortality risk for people of age
years, who have I9_CARDMYOALC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 1.353% |
| 5 | No data | 8.938% |
| 10 | No data | 20.736% |
| 15 | No data | 36.196% |
| 20 | No data | 53.948% |
Relationships between endpoints
↥Index endpoint: I9_CARDMYOALC – Alcoholic cardiomyopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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