granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Other and unspecified granulomatous disorders of skin and subcutaneous tissue
DOID EFO Endpoint Browser PheWeb
L12_GRANULOMASKINNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
131 |
4. Check minimum number of eventsNone |
131 |
5. Include endpointsNone |
131 |
6. Filter based on genotype QC (FinnGen only) |
128 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified granulomatous disorders of skin and subcutaneous tissue
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 993 | 626 | 359 |
| Only index persons | 911 | 590 | 321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.54 | 49.28 | 50.25 |
| Only index persons | 49.87 | 49.92 | 49.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 128 | 90 | 38 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 57.59 | 56.11 | 61.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 131
- Matched controls
- 1310
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
91.8
77
*
L92.8
ICD-10 Finland
Other granulomatous disorders of skin and subcutaneous tissue
+∞
63.9
56
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
10.0
30.4
42
59
L92.0
ICD-10 Finland
Granuloma annulare
233.9
20.1
20
*
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
84.7
7.5
8
*
J04BA02
ATC
dapsone; oral
84.7
7.5
8
*
H02AB06
ATC
prednisolone; systemic
2.7
7.2
77
452
D07AD01
ATC
clobetasol; topical
3.2
7.1
33
124
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
73.3
6.5
7
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.9
6.4
38
164
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
28.2
6.3
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
6.3
27
96
L98.0
ICD-10 Finland
Pyogenic granuloma
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
644
1.98
3.34
11.0
9.4
4.06
4.13
e9/l
0.12
73
560
72
514
1.89
3.17
10.3
6.1
1.21
1.22
mmol/l
0.49
64
443
9
21
4.52
3.05
1.4
1.3
—
—
—
0
0
39
240
1.89
2.64
2.4
1.9
2.40
3.06
mg/l
1.44
32
204
8
20
4.19
2.61
1.6
1.5
—
—
—
0
0
6
11
5.66
2.57
1.0
1.0
—
—
—
0
0
9
27
3.50
2.44
4.2
2.1
—
—
—
0
0
10
33
3.19
2.41
3.3
3.2
—
—
—
0
0
102
852
1.89
2.38
9.7
7.6
76.10
76.72
u/l
0.09
96
795
6
13
4.78
2.30
1.2
1.1
—
—
—
0
0
13
54
2.56
2.28
5.0
2.8
125.46
133.09
g/l
0.57
13
54
21
112
2.04
2.11
10.1
6.3
102.67
103.80
mmol/l
0.49
21
112
11
44
2.64
2.07
4.1
2.6
0.67
0.67
%
0.03
11
44
11
46
2.52
1.91
7.2
2.8
25.45
25.07
mmol/l
0.19
11
46
17
87
2.10
1.90
5.7
3.2
5.94
5.90
kpa
0.06
17
87
6
17
3.65
1.86
1.2
1.7
—
—
—
0
0
5
12
4.29
1.84
2.8
3.2
—
—
—
0
0
87
719
1.63
1.83
2.7
3.3
—
—
—
0
0
62
475
1.58
1.79
32.6
9.6
1.61
1.21
inr
1.22
15
140
5
13
3.95
1.73
2.2
2.2
—
—
—
0
0
6
19
3.26
1.68
1.2
1.7
—
—
—
0
0
14
70
2.12
1.66
4.9
2.6
4.17
4.25
kpa
0.05
14
70
12
57
2.22
1.60
3.8
4.0
5.15
5.04
kpa
0.25
12
52
6
20
3.09
1.60
1.3
1.3
—
—
—
0
0
6
20
3.09
1.60
1.0
1.2
—
—
—
0
0
75
611
1.53
1.59
7.6
4.1
7.17
6.46
mmol/l
1.82
69
558
60
466
1.53
1.58
8.8
5.1
1.20
1.22
mmol/l
0.77
52
431
111
993
1.77
1.55
5.3
4.9
1.86
1.84
mu/l
0.06
106
912
5
15
3.42
1.54
2.0
2.7
106.80
107.33
mmol/l
—
5
15
7
27
2.68
1.53
1.1
1.1
—
—
—
0
0
6
21
2.94
1.52
1.8
2.0
—
—
—
0
0
6
21
2.94
1.52
1.8
2.0
—
—
—
0
0
10
45
2.32
1.50
8.0
3.3
39.91
45.74
%
—
10
45
13
66
2.08
1.49
5.2
3.3
300.92
156.02
ng/l
0.75
13
58
9
39
2.40
1.46
1.2
1.7
—
—
—
0
0
6
22
2.81
1.45
1.2
1.8
—
—
—
0
0
64
515
1.47
1.37
4.1
2.5
—
—
—
0
0
33
231
1.57
1.36
1.8
1.6
1.12
0.83
mg/l
0.38
21
188
119
1100
1.89
1.29
22.3
13.5
23.71
22.42
mg/l
0.17
101
869
13
72
1.89
1.20
2.2
1.4
—
—
—
0
0
7
31
2.33
1.12
1.1
1.3
—
—
—
0
0
9
46
2.03
1.06
2.1
2.1
—
—
—
0
0
5
22
2.32
1.04
2.0
1.7
—
—
—
0
0
47
375
1.40
0.99
3.3
3.3
2.33
2.35
mmol/l
0.45
41
333
9
51
1.82
0.97
15.8
6.9
1.13
1.49
%
—
9
51
9
51
1.82
0.97
15.7
6.8
0.68
0.71
%
—
9
51
5
101
0.48
0.94
2.0
1.5
—
—
—
0
0
6
28
2.20
0.93
1.8
1.8
—
—
—
0
0
6
30
2.05
0.88
1.8
1.7
—
—
—
0
0
8
44
1.87
0.87
1.8
1.8
—
—
—
0
0
64
546
1.34
0.87
5.8
3.6
0.00
0.00
estimate
-0.00
12
117
8
46
1.79
0.84
2.5
1.9
0.86
7.43
ug/l
—
8
40
15
98
1.60
0.83
3.5
3.2
—
—
—
0
0
18
124
1.52
0.80
7.8
4.6
259.39
239.93
u/l
0.33
18
118
8
48
1.71
0.80
2.3
5.2
26.50
25.07
mmol/l
—
8
48
5
25
2.04
0.73
1.6
1.4
—
—
—
0
0
7
43
1.66
0.68
2.4
3.6
26.20
24.25
mmol/l
—
7
43
26
200
1.37
0.67
1.4
1.3
24.31
31.67
iu/ml
—
8
65
63
551
1.28
0.67
5.9
3.6
0.00
0.00
estimate
-0.00
11
108
6
103
0.56
0.65
1.8
1.8
1.73
1.42
%
—
6
89
18
131
1.43
0.63
1.8
2.1
—
—
—
0
0
62
544
1.27
0.63
8.0
4.8
0.00
0.00
estimate
-0.00
11
110
5
30
1.69
0.62
1.0
1.2
—
—
—
0
0
6
35
1.75
0.58
1.8
1.4
—
—
—
0
0
110
1045
1.33
0.52
5.2
4.3
6.25
5.88
mmol/l
1.54
102
967
16
120
1.38
0.49
1.8
1.9
—
—
—
0
0
36
305
1.25
0.48
5.1
3.7
14.66
10.47
mg/mmol
0.17
26
188
20
159
1.30
0.43
4.0
3.2
0.81
0.81
mmol/l
0.04
20
151
22
178
1.28
0.42
2.3
1.9
—
—
—
0
0
52
464
1.20
0.42
3.6
2.7
126.33
94.70
ug/l
0.26
47
426
124
1209
1.48
0.41
30.1
19.7
254.69
252.20
e9/l
0.15
124
1179
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
9
68
1.35
0.38
1.9
2.0
—
—
—
0
0
16
126
1.31
0.37
16.8
7.7
—
—
—
0
0
24
201
1.24
0.35
1.2
1.3
2.46
11.63
u/ml
1.36
12
73
109
1048
1.24
0.35
4.8
4.2
4.50
4.68
mmol/l
1.01
104
978
6
45
1.35
0.34
1.7
1.3
—
—
—
0
0
18
217
0.80
0.32
1.9
1.4
—
—
—
0
0
46
415
1.17
0.32
4.9
3.8
26.82
30.58
ng/l
0.22
33
276
124
1210
1.46
0.32
30.3
19.7
133.36
134.21
g/l
0.26
124
1189
108
1041
1.21
0.31
4.8
4.2
1.42
1.50
mmol/l
1.36
102
969
105
1010
1.20
0.31
16.7
12.4
77.52
82.04
ml/min/173m2
1.23
90
817
102
979
1.19
0.31
7.5
5.3
42.80
39.38
mmol/mol
2.16
95
917
25
214
1.21
0.31
1.8
1.7
430.65
474.99
pmol/l
0.23
20
185
47
426
1.16
0.31
2.2
1.9
115.85
94.33
pmol/l
1.75
28
204
104
1000
1.19
0.30
4.5
3.7
1.44
1.29
mmol/l
0.94
98
927
10
77
1.32
0.27
2.4
3.0
61.20
61.87
ml/min/173m2
—
5
30
15
123
1.25
0.27
2.1
1.7
—
—
—
0
0
110
1068
1.19
0.25
5.4
4.7
2.54
2.75
mmol/l
1.51
104
991
46
423
1.13
0.24
7.1
3.6
—
—
—
0
0
5
37
1.36
0.24
1.8
1.6
—
—
—
0
0
5
39
1.29
0.23
6.4
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
6.99
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
9
115
0.77
0.21
3.4
2.9
0.87
0.67
ug/l
—
9
78
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
8
68
1.19
0.17
1.0
1.0
—
—
—
0
0
18
160
1.14
0.15
3.8
4.7
29.17
19.76
%
—
9
81
123
1210
1.27
0.14
31.2
19.5
39.12
40.07
%
0.75
117
1137
74
716
1.08
0.12
3.5
2.8
50.66
42.59
u/l
0.39
67
671
28
260
1.10
0.12
4.1
2.0
—
—
—
0
0
5
46
1.09
0.09
1.6
1.4
—
—
—
0
0
5
46
1.09
0.09
1.6
1.4
—
—
—
0
0
5
46
1.09
0.09
1.6
1.4
—
—
—
0
0
6
55
1.10
0.09
1.7
1.7
—
—
—
0
0
22
236
0.92
0.09
1.4
1.6
—
—
—
0
0
5
64
0.77
0.08
1.4
1.4
—
—
—
0
0
7
65
1.08
0.08
2.3
1.7
—
—
—
0
0
7
65
1.08
0.08
1.1
1.2
—
—
—
0
0
28
265
1.07
0.07
1.3
1.2
5.55
0.79
u/ml
—
8
82
38
393
0.95
0.05
5.8
3.2
—
—
—
0
0
27
259
1.05
0.04
1.6
1.5
20.80
21.99
nmol/l
0.12
20
219
21
201
1.05
0.03
4.5
4.8
2.15
3.80
ug/l
0.48
21
178
13
131
0.99
0.00
3.7
2.2
8.54
7.58
umol/l
0.09
13
113
13
125
1.04
0.00
2.5
1.8
—
—
—
0
0
30
304
0.98
0.00
7.8
3.6
0.00
0.00
estimate
-0.00
11
109
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
9.51
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
60.71
—
0
7
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
30.19
—
0
8
5
49
1.02
-0.00
1.8
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
80
1.00
-0.00
1.5
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
12.00
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_GRANULOMASKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANULOMASKINNAS | 1.273 [0.96, 1.7] | 0.099 |
| Birth year | 0.994 [0.99, 1.0] | 0.152 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 568 females with L12_GRANULOMASKINNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANULOMASKINNAS | 1.534 [1.1, 2.13] | 0.011 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 329 males with L12_GRANULOMASKINNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_GRANULOMASKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.299% |
| 5 | 0.743% | 1.711% |
| 10 | 1.917% | 4.362% |
| 15 | 3.524% | 8.553% |
| 20 | 6.092% | 14.414% |
Relationships between endpoints
↥Index endpoint: L12_GRANULOMASKINNAS – Other and unspecified granulomatous disorders of skin and subcutaneous tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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