granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Other and unspecified granulomatous disorders of skin and subcutaneous tissue
DOID EFO Endpoint Browser PheWeb
L12_GRANULOMASKINNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
126 |
4. Check minimum number of eventsNone |
126 |
5. Include endpointsNone |
126 |
6. Filter based on genotype QC (FinnGen only) |
126 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified granulomatous disorders of skin and subcutaneous tissue
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 993 | 626 | 359 |
| Only index persons | 911 | 590 | 321 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.54 | 49.28 | 50.25 |
| Only index persons | 49.87 | 49.92 | 49.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 126 | 89 | 37 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 55.21 | 53.15 | 60.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 113
- Matched controls
- 1131
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
78.5
66
*
L92.8
ICD-10 Finland
Other granulomatous disorders of skin and subcutaneous tissue
+∞
56.0
49
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
13.2
19.2
35
37
L92.0
ICD-10 Finland
Granuloma annulare
+∞
17.1
16
*
H02AB06
ATC
prednisolone; systemic
3.1
7.7
67
363
J04BA02
ATC
dapsone; oral
73.8
6.5
7
*
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
73.8
6.5
7
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
9
17
5.61
3.58
1.4
1.1
—
—
—
0
0
10
28
3.79
3.27
3.3
3.0
—
—
—
0
0
83
621
1.99
3.26
11.3
9.1
4.1
4.1
e9/l
0.12
71
541
69
487
1.92
3.21
10.5
6.2
1.2
1.2
mmol/l
0.39
61
417
38
230
1.93
2.72
2.4
2.0
2.4
3.0
mg/l
1.21
31
195
99
817
1.99
2.58
9.8
7.4
75.7
76.5
u/l
0.11
93
762
6
11
5.66
2.57
1.0
1.0
—
—
—
0
0
9
26
3.65
2.53
4.2
2.1
—
—
—
0
0
8
21
3.99
2.51
1.6
1.5
—
—
—
0
0
6
12
5.19
2.43
1.2
1.3
—
—
—
0
0
5
10
5.15
2.09
2.8
3.2
—
—
—
0
0
11
44
2.64
2.07
7.2
2.8
25.5
24.9
mmol/l
0.29
11
44
6
15
4.14
2.06
1.2
1.5
—
—
—
0
0
12
52
2.45
1.94
5.3
2.8
125.1
132.8
g/l
0.52
12
52
7
22
3.31
1.91
1.1
1.1
—
—
—
0
0
6
17
3.65
1.86
1.2
1.6
—
—
—
0
0
84
692
1.64
1.83
2.7
3.3
—
—
—
0
0
6
18
3.45
1.77
1.3
1.2
—
—
—
0
0
73
585
1.59
1.75
7.8
4.0
7.2
6.4
mmol/l
1.84
67
532
5
13
3.96
1.73
2.2
2.2
—
—
—
0
0
6
19
3.26
1.68
1.0
1.2
—
—
—
0
0
6
19
3.26
1.68
1.2
1.6
—
—
—
0
0
10
43
2.44
1.65
8.0
3.2
39.9
45.6
%
—
10
43
16
85
2.01
1.64
6.0
3.8
5.9
5.9
kpa
0.02
16
85
13
64
2.15
1.60
5.2
3.0
300.9
95.5
ng/l
1.30
13
54
107
953
1.81
1.59
5.3
4.8
1.8
1.8
mu/l
0.00
102
875
13
65
2.12
1.55
2.2
1.4
—
—
—
0
0
57
443
1.52
1.50
8.9
5.2
1.2
1.2
mmol/l
0.51
47
410
16
90
1.89
1.41
1.4
1.9
431.4
362.2
nmol/l
0.60
16
85
61
492
1.46
1.29
6.7
4.0
—
—
—
0
0
6
25
2.47
1.26
1.8
1.6
—
—
—
0
0
31
218
1.56
1.25
1.8
1.6
1.2
0.8
mg/l
0.49
20
176
46
357
1.45
1.17
3.4
3.1
2.3
2.3
mmol/l
0.48
38
314
5
20
2.56
1.16
2.0
1.6
—
—
—
0
0
114
1060
1.79
1.10
22.8
13.2
23.7
22.7
mg/l
0.13
97
836
9
45
2.08
1.07
2.1
2.2
—
—
—
0
0
10
53
1.96
1.04
3.9
4.2
5.2
5.0
kpa
—
10
44
9
50
1.86
0.99
15.8
7.2
1.1
1.5
%
—
9
50
7
37
1.94
0.95
1.3
1.8
—
—
—
0
0
6
27
2.28
0.95
1.8
1.6
—
—
—
0
0
15
95
1.66
0.92
3.5
3.2
—
—
—
0
0
8
42
1.96
0.90
1.8
1.9
—
—
—
0
0
62
528
1.34
0.86
5.8
3.5
0.0
0.0
estimate
—
10
109
6
31
1.98
0.85
1.2
1.3
—
—
—
0
0
5
100
0.48
0.81
2.0
1.8
1.7
1.4
%
—
5
88
5
23
2.22
0.77
3.0
1.1
102.8
99.0
%
—
5
23
5
95
0.51
0.69
2.0
1.5
—
—
—
0
0
18
130
1.45
0.66
1.8
2.1
—
—
—
0
0
17
123
1.44
0.62
8.2
4.6
262.2
240.6
u/l
0.36
17
117
25
198
1.33
0.55
1.4
1.3
22.5
24.2
iu/ml
—
7
61
6
38
1.61
0.55
1.8
1.4
—
—
—
0
0
106
1004
1.35
0.55
5.1
4.3
6.2
5.9
mmol/l
1.23
98
928
51
444
1.25
0.55
3.6
2.7
128.3
94.9
ug/l
0.27
46
409
16
119
1.39
0.51
1.8
1.8
—
—
—
0
0
60
536
1.23
0.50
6.1
3.6
0.0
0.0
estimate
0.00
11
107
7
48
1.48
0.47
2.4
5.5
25.7
25.1
mmol/l
—
7
48
59
529
1.22
0.47
8.3
4.8
0.0
0.0
estimate
0.00
11
107
46
402
1.23
0.47
2.2
1.9
118.7
95.5
pmol/l
2.00
27
197
16
121
1.37
0.47
16.8
7.8
—
—
—
0
0
101
959
1.27
0.44
4.5
3.7
1.4
1.3
mmol/l
0.61
95
888
19
150
1.31
0.43
4.1
3.2
0.8
0.8
mmol/l
0.02
19
142
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
21
170
1.28
0.40
2.3
1.9
—
—
—
0
0
5
35
1.45
0.40
6.4
2.0
—
—
—
0
0
9
67
1.37
0.39
1.9
1.9
—
—
—
0
0
105
1008
1.25
0.36
4.8
4.2
4.5
4.7
mmol/l
1.13
100
939
45
402
1.19
0.36
5.0
3.8
26.8
31.0
ng/l
0.24
32
263
6
44
1.38
0.35
1.7
1.3
—
—
—
0
0
24
202
1.23
0.34
1.8
1.7
440.8
466.6
pmol/l
0.12
19
174
33
289
1.19
0.32
5.7
3.9
14.8
11.0
mg/mmol
0.14
25
179
104
1001
1.22
0.32
4.9
4.1
1.4
1.5
mmol/l
1.16
98
930
100
961
1.20
0.30
16.6
12.3
77.8
82.2
ml/min/173m2
1.12
86
774
98
941
1.19
0.29
7.5
5.2
42.7
39.2
mmol/mol
2.06
91
879
10
76
1.34
0.29
2.4
3.1
61.2
60.3
ml/min/173m2
—
5
30
8
63
1.29
0.28
1.0
1.0
—
—
—
0
0
45
410
1.15
0.27
7.2
3.6
—
—
—
0
0
72
679
1.14
0.26
3.5
2.7
50.8
43.1
u/l
0.35
65
637
106
1027
1.20
0.26
5.5
4.7
2.5
2.8
mmol/l
1.50
101
950
18
211
0.83
0.25
1.9
1.4
—
—
—
0
0
18
152
1.21
0.25
3.8
4.6
29.2
20.0
%
—
9
75
5
37
1.37
0.24
1.8
1.6
—
—
—
0
0
119
1165
1.39
0.23
30.9
19.5
133.4
134.3
g/l
0.26
119
1144
14
116
1.23
0.23
2.1
1.7
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
9
110
0.80
0.21
3.4
2.8
0.9
0.7
ug/l
—
9
73
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
7
59
1.20
0.18
1.1
1.2
—
—
—
0
0
7
62
1.14
0.17
2.3
1.7
—
—
—
0
0
27
245
1.13
0.17
4.2
2.1
—
—
—
0
0
22
197
1.14
0.17
1.2
1.3
2.6
11.6
u/ml
1.29
11
72
27
247
1.12
0.15
1.3
1.2
5.5
0.8
u/ml
—
8
74
5
45
1.12
0.10
1.6
1.4
—
—
—
0
0
5
45
1.12
0.10
1.6
1.4
—
—
—
0
0
5
45
1.12
0.10
1.6
1.4
—
—
—
0
0
5
48
1.04
0.09
1.8
1.5
—
—
—
0
0
6
55
1.10
0.09
1.7
1.7
—
—
—
0
0
26
244
1.08
0.09
1.7
1.5
21.3
21.3
nmol/l
0.00
19
206
13
118
1.11
0.07
2.5
1.8
—
—
—
0
0
13
123
1.06
0.02
3.7
2.1
8.5
7.5
umol/l
0.09
13
105
20
193
1.04
0.01
4.4
4.7
2.2
3.8
ug/l
0.45
20
173
22
227
0.96
0.01
1.4
1.6
—
—
—
0
0
29
295
0.98
0.00
8.1
3.6
0.0
0.0
estimate
0.00
11
106
37
374
0.98
0.00
5.9
3.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
0.00
1.5
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
9.5
—
0
5
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
59
0.84
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_GRANULOMASKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANULOMASKINNAS | 1.273 [0.96, 1.7] | 0.099 |
| Birth year | 0.994 [0.99, 1.0] | 0.152 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 568 females with L12_GRANULOMASKINNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANULOMASKINNAS | 1.534 [1.1, 2.13] | 0.011 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 329 males with L12_GRANULOMASKINNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_GRANULOMASKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.299% |
| 5 | 0.743% | 1.711% |
| 10 | 1.917% | 4.362% |
| 15 | 3.524% | 8.553% |
| 20 | 6.092% | 14.414% |
Relationships between endpoints
↥Index endpoint: L12_GRANULOMASKINNAS – Other and unspecified granulomatous disorders of skin and subcutaneous tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data