granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
213 |
4. Check minimum number of eventsNone |
213 |
5. Include endpointsNone |
213 |
6. Filter based on genotype QC (FinnGen only) |
213 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L92
- Name in latin
- Necrobiosis lipoidica non alibi classificata
Similar endpoints
↥List of similar endpoints to
Necrobiosis lipoidica, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1091 | 836 | 253 |
| Only index persons | 1019 | 789 | 230 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.63 | 46.08 | 48.41 |
| Only index persons | 45.18 | 44.62 | 47.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 213 | 164 | 49 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | 36.87 | 34.63 | 44.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 196
- Matched controls
- 1961
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
+∞
264.3
189
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
39.9
74.0
95
45
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
31.7
72.3
100
62
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
45.5
72.1
89
35
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
52.5
71.4
85
28
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
31.8
69.2
95
56
103
Kela drug reimbursment
Diabetes, insulin-treated
17.7
68.4
133
208
215
Kela drug reimbursment
Diabetes, non-insulin-treated
17.9
68.1
130
194
A10AE04
ATC
insulin glargine; parenteral
24.7
66.2
100
79
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
81.0
63.0
69
13
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
50.9
62.0
74
23
H04AA01
ATC
glucagon; nasal, parenteral
48.7
61.4
74
24
A10AA01
ATC
NA
40.4
56.4
71
27
A10AE05
ATC
insulin detemir; parenteral
30.3
55.6
76
40
A10AA02
ATC
NA
37.6
55.4
71
29
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
41.6
52.2
65
23
T89
ICPC
Diabetes insulin dependent
32.6
51.8
69
32
A10AE06
ATC
insulin degludec; parenteral
35.0
41.7
54
21
SPAT1262
SPAT
Handing over of treatment supplies
9.9
37.6
87
146
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
49.5
36.1
43
11
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
72.9
32.3
36
6
H3603, E103
ICD-10 Finland
NA
56.5
31.9
37
8
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
70.4
31.3
35
6
E10
ICD-10 Finland
Type 1 diabetes mellitus
28.4
30.3
41
18
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
91.1
28.7
31
*
XCK10
NOMESCO Finland
Photography of fundus of eye
9.7
28.2
62
89
H3601, E103
ICD-10 Finland
NA
73.1
27.9
31
5
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
27.4
27.8
38
17
CKC12
NOMESCO Finland
Photocoagulation of retina
15.9
27.1
45
36
H3600, E103
ICD-10 Finland
NA
37.0
27.0
34
11
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
48.1
24.4
29
7
S97
ICPC
Chronic ulcer skin
20.0
23.3
35
21
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
16.0
23.2
38
29
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
258.9
23.1
23
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
36.0
22.2
28
9
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.2
21.4
47
65
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.8
20.8
67
160
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
61.5
19.4
22
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
77.8
19.1
21
*
177
Kela drug reimbursment
Insulin glargine 300 U / ml
22.1
18.8
27
14
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
22.1
18.8
27
14
D07AD01
ATC
clobetasol; topical
5.5
18.8
63
156
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
41.0
18.0
22
6
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
21.8
17.4
25
13
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
+∞
16.9
16
*
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
20.8
16.5
24
13
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.3
15.7
44
86
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
9.6
15.5
32
39
J01FF01
ATC
clindamycin; systemic
3.7
14.8
82
317
M65.3
ICD-10 Finland
Trigger finger
11.8
14.8
27
26
171
Kela drug reimbursment
Degludekinsuliini
161.5
14.7
15
*
A10AA03
ATC
NA
22.1
14.1
20
10
TQW80
NOMESCO Finland
Local dermatologic skincare
20.1
13.7
20
11
H36.01
ICD-10 Finland
Diabetic maculopathy
23.2
13.6
19
9
D07AC01
ATC
betamethasone; topical
3.3
13.6
91
404
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.3
13.4
37
70
SPAT1148
SPAT
Treatment of chronic ulcer or burn
5.5
13.2
41
90
H43.1
ICD-10 Finland
Vitreous haemorrhage
17.0
12.9
20
13
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
3.8
12.8
63
218
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.2
12.8
10
511
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
34.6
12.8
16
5
CKD40
NOMESCO Finland
Endophotocoagulation of retina
34.6
12.8
16
5
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
21.8
12.7
18
9
L92.0
ICD-10 Finland
Granuloma annulare
138.4
12.6
13
*
C10AA01
ATC
simvastatin; oral
3.3
12.6
82
353
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
23.1
12.2
17
8
E0000UV
ATC
NA
3.0
12.1
108
572
CKC15
NOMESCO Finland
Panretinal photocoagulation
49.9
12.0
14
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.2
12.0
50
149
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
13.8
11.9
20
16
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
11.1
11.8
22
22
XCD10
NOMESCO Finland
Electrophysiological examination of eye
12.9
11.6
20
17
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
11.3
89
428
A10BA02
ATC
metformin; oral
3.4
10.6
58
215
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.8
10.5
30
59
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
20.1
10.4
15
8
A10AB06
ATC
insulin glulisine; parenteral
24.9
10.4
14
6
C03CA01
ATC
furosemide; systemic
3.4
9.9
53
191
T90
ICPC
Diabetes non-insulin dependent
3.6
9.9
49
168
A10BK01
ATC
dapagliflozin; oral
9.9
9.8
19
21
C10AA05
ATC
atorvastatin; oral
3.0
9.8
66
282
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
57.9
9.7
11
*
H3602, E103
ICD-10 Finland
NA
31.7
9.5
12
*
7098B
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Other specified disorders of skin[NECROBIOSIS LIPOIDICA]
+∞
9.4
9
*
J01DA01
ATC
[U] cefalexin; systemic
2.7
9.3
142
965
ZZA00
NOMESCO Finland
Split skin graft
16.6
9.2
14
9
A46
ICD-10 Finland
Erysipelas
4.5
9.1
33
85
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
38.6
9.1
11
*
ZXA10
NOMESCO Finland
Bilateral
3.5
9.0
45
155
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
6.7
8.9
22
36
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
14.9
8.8
14
10
TK800
NOMESCO Finland
Hemodialysis
14.9
8.8
14
10
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
52.4
8.8
10
*
R4180
NOMESCO Finland
Podiatric therapy
52.4
8.8
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.2
8.7
51
196
D07AC13
ATC
mometasone; topical
2.7
8.6
75
367
C09AA02
ATC
enalapril; systemic
3.5
8.6
42
141
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
28.9
8.6
11
*
Z94.0
ICD-10 Finland
Kidney transplant status
28.9
8.6
11
*
S18
ICPC
Laceration/cut
2.6
8.5
84
444
V03AE01
ATC
polystyrene sulfonate; oral
93.9
8.5
9
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
93.9
8.5
9
*
WZC30
NOMESCO Finland
Teaching
3.9
8.4
35
103
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
9.6
8.2
16
18
127
Kela drug reimbursment
Transplant complication
18.1
8.2
12
7
A10AD04
ATC
insulin lispro; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
34.9
8.2
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
8.1
48
184
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
7.1
8.1
19
29
B03XA02
ATC
darbepoetin alfa; parenteral
23.2
8.1
11
5
E000001
ATC
NA
2.8
8.1
60
268
C09AA05
ATC
ramipril; oral
3.3
8.0
43
152
C10AX09
ATC
ezetimibe; oral
4.8
7.9
26
61
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.3
7.8
42
150
R11
ICD-10 Finland
Nausea and vomiting
4.7
7.8
26
62
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.3
7.8
40
140
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
26.2
7.6
10
*
205
Kela drug reimbursment
Chronic hypertension
3.0
7.5
48
192
J01MA14
ATC
moxifloxacin; systemic
5.1
7.5
23
50
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
9.9
7.4
14
15
Z96.4
ICD-10 Finland
Presence of endocrine implants
+∞
7.3
7
*
D03BA02
ATC
collagenase; topical
+∞
7.3
7
*
D03BA52
ATC
collagenase, combinations; topical
+∞
7.3
7
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
16.5
7.3
11
7
J01MA02
ATC
ciprofloxacin; systemic
2.4
7.2
77
417
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
20.9
7.2
10
5
ACC51
NOMESCO Finland
Release of median nerve
4.2
7.1
26
68
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.0
7.1
43
168
C08CA01
ATC
amlodipine; oral
2.6
7.0
56
259
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
11.5
6.9
12
11
MAX99
NOMESCO Finland
Assistance to normal delivery
0.0
6.9
*
194
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.5
6.8
32
104
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
23.4
6.7
9
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
5.7
6.6
18
34
A12AA04
ATC
calcium carbonate; oral
14.9
6.5
10
7
CKD15
NOMESCO Finland
Injection of vitreous substitute
72.1
6.5
7
*
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
72.1
6.5
7
*
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
72.1
6.5
7
*
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
72.1
6.5
7
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.2
6.4
8
321
L84
ICD-10 Finland
Corns and callosities
11.6
6.4
11
10
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
11.6
6.4
11
10
N18.8
ICD-10 Finland
Other chronic renal failure
11.6
6.4
11
10
XCD20
NOMESCO Finland
Photoangiography of eye
18.8
6.3
9
5
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
6.3
6
*
QXA20
NOMESCO Finland
Skin abrasion, unspecified location
+∞
6.3
6
*
E10.09
ICD-10 Finland
Insulin-dependent diabetes mellitus - With coma
+∞
6.3
6
*
JLE03
NOMESCO Finland
Allogenic total transplantation of pancreas with pancreaticoenterostomy
+∞
6.3
6
*
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
27.6
6.3
8
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
27.6
6.3
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
6.3
35
129
CKC10
NOMESCO Finland
Local photocoagulation of retina
13.1
6.1
10
8
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
9.0
6.1
12
14
MAA00
NOMESCO Finland
Amniocentesis
5.9
6.1
16
29
E000003
ATC
NA
4.3
6.0
21
53
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
144
393
9.22
58.21
7.8
3.9
25.1
8.8
mg/mmol
1.67
114
240
32
26
14.31
33.14
3.0
2.5
224.7
183.9
ug/min
0.10
26
16
45
99
5.50
20.26
7.9
3.4
115.9
75.6
ng/l
1.38
39
90
62
205
3.86
16.42
4.7
2.0
2.2
2.5
g/l
2.06
56
189
99
442
3.32
16.39
2.1
1.6
1.3
1.4
mmol/l
0.27
89
396
102
476
3.19
15.48
1.7
1.3
2.1
1.0
u/ml
0.40
34
136
57
187
3.80
15.17
4.6
2.1
25.3
23.6
%
0.47
42
159
41
107
4.51
14.87
7.9
3.2
1.3
2.1
mmol/l
0.86
35
79
63
225
3.56
14.73
4.7
2.0
13.2
14.4
umol/l
0.55
56
202
151
908
3.28
14.31
8.6
4.6
10.1
6.4
mmol/l
12.84
140
808
127
737
2.79
12.04
3.8
2.2
70.0
75.6
nmol/l
1.52
118
672
61
244
3.10
11.59
2.0
1.6
1169.4
1139.7
nmol/l
0.10
52
181
113
632
2.68
11.31
11.5
4.2
34.1
36.7
g/l
4.51
104
592
29
79
4.09
9.82
3.5
2.2
-0.9
1.2
mmol/l
1.31
21
58
33
104
3.57
9.08
2.2
1.4
—
—
—
0
0
76
388
2.49
8.73
3.1
2.0
2.8
2.8
mg/l
0.03
69
333
22
53
4.51
8.69
2.0
1.4
265.0
313.1
ug/g
0.48
15
29
21
49
4.65
8.62
2.5
2.4
1.5
1.4
g/l
0.20
21
43
12
16
7.89
8.50
1.9
1.4
—
—
—
0
0
17
34
5.35
8.29
2.2
1.2
—
—
—
0
0
114
708
2.31
8.28
16.9
6.5
1.2
1.2
mmol/l
0.86
103
601
18
38
5.08
8.28
1.6
1.2
—
—
—
0
0
104
622
2.31
8.25
2.4
1.9
99.8
95.9
pmol/l
0.31
57
317
74
386
2.41
8.00
3.9
2.6
324.0
3716.3
umol/l
1.31
68
343
193
1541
3.69
7.95
14.3
4.6
56.3
38.4
mmol/mol
27.75
188
1454
16
33
5.16
7.54
2.4
1.2
86.5
121.8
u/ml
—
6
5
87
501
2.25
7.36
7.1
2.5
55.1
54.6
u/l
0.03
81
459
7
0
+∞
7.33
10.1
0.0
—
—
—
0
0
35
133
2.95
7.07
5.8
11.1
1.3
1.1
mmol/l
0.08
29
102
37
154
2.70
6.30
8.5
6.6
103.4
104.3
mmol/l
0.52
37
149
57
302
2.21
5.72
2.0
1.7
93617478.6
456.8
pmol/l
0.49
47
263
27
100
2.95
5.68
3.0
2.9
69.8
78.9
ml/min/173m2
0.33
13
41
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
25
5.03
5.56
2.5
2.0
0.3
0.4
u/ml
—
5
11
15
38
4.17
5.54
1.7
1.1
—
—
—
0
0
21
70
3.22
5.27
8.2
13.4
24.7
24.5
mmol/l
0.06
21
65
46
233
2.24
5.10
2.1
1.6
—
—
—
0
0
36
166
2.41
4.94
1.2
1.3
129.1
144.3
iu/ml
0.14
21
73
82
523
1.92
4.87
3.6
3.0
49.9
29.9
ng/l
0.63
53
276
123
899
1.87
4.74
5.8
2.9
105.4
74.5
ug/l
1.38
114
839
84
544
1.90
4.74
6.1
2.8
—
—
—
0
0
8
8
10.33
4.56
2.6
2.0
—
—
—
0
0
170
1397
2.07
4.44
5.8
4.3
14.8
14.5
pmol/l
0.84
163
1304
37
182
2.25
4.38
4.0
2.5
3.9
6.1
umol/l
1.76
29
150
0
97
0.00
3.75
0.0
1.7
—
—
—
0
0
32
159
2.19
3.69
2.3
1.5
—
—
—
0
0
11
30
3.81
3.69
1.1
1.1
—
—
—
0
0
6
6
10.24
3.52
1.2
1.2
—
—
—
0
0
54
335
1.82
3.34
1.3
1.3
16.1
9.3
u/ml
0.20
19
133
19
78
2.58
3.32
3.7
2.2
168.6
123.4
ng/l
0.18
13
71
155
1286
1.75
3.28
5.0
3.7
14.8
9.7
mm/h
4.27
146
1198
31
163
2.06
3.10
2.4
1.6
—
—
—
0
0
10
29
3.57
3.08
1.2
1.1
—
—
—
0
0
28
142
2.12
3.07
22.7
13.8
2.0
1.3
inr
—
5
25
5
5
10.19
2.99
1.4
1.0
110.8
109.2
%
—
5
5
126
1006
1.62
2.94
11.1
8.7
4.6
4.1
e9/l
2.31
115
882
29
152
2.05
2.93
5.6
2.4
25.8
28.6
u/l
0.23
24
132
7
13
5.53
2.89
1.1
1.0
—
—
—
0
0
11
36
3.17
2.85
2.6
1.4
—
—
—
0
0
27
142
2.03
2.70
1.3
2.4
17710.9
4536.5
u/l
—
8
59
53
348
1.70
2.66
1.4
1.3
11.0
24.3
iu/ml
1.96
13
107
38
234
1.76
2.38
4.6
2.6
6.7
3.2
e6/l
0.74
27
125
56
385
1.62
2.34
2.4
1.6
0.8
0.8
mg/l
0.12
45
285
7
18
3.98
2.27
1.0
1.1
—
—
—
0
0
6
14
4.38
2.16
1.0
1.4
—
—
—
0
0
6
15
4.08
2.05
1.2
1.3
—
—
—
0
0
17
85
2.09
1.96
1.7
1.4
—
—
—
0
0
10
39
2.64
1.95
1.5
1.3
—
—
—
0
0
26
154
1.78
1.86
4.6
2.9
—
—
—
0
0
105
862
1.43
1.81
7.2
4.4
0.0
0.0
estimate
0.00
19
172
6
18
3.40
1.76
1.0
1.1
—
—
—
0
0
106
876
1.42
1.74
4.9
3.3
0.0
0.0
estimate
0.00
12
166
105
867
1.42
1.73
4.7
3.2
0.0
0.0
estimate
0.00
18
172
39
264
1.58
1.72
4.8
3.1
172.5
235.9
ng/l
0.14
27
165
37
248
1.60
1.70
4.8
2.4
0.8
0.8
e6/l
0.01
28
139
14
69
2.10
1.69
1.3
1.3
—
—
—
0
0
16
84
1.98
1.64
2.2
1.5
—
—
—
0
0
5
14
3.63
1.62
1.4
2.1
—
—
—
0
0
7
26
2.75
1.59
1.6
1.6
—
—
—
0
0
7
26
2.75
1.59
1.3
1.7
—
—
—
0
0
8
33
2.48
1.55
1.3
1.6
—
—
—
0
0
47
340
1.49
1.55
2.7
2.8
1011.7
786.1
ng/l
0.30
39
285
12
58
2.13
1.52
1.6
1.9
—
—
—
0
0
57
431
1.44
1.50
6.5
2.6
0.2
0.3
e6/l
0.45
51
315
5
16
3.17
1.44
1.2
1.8
—
—
—
0
0
82
668
1.37
1.40
4.9
3.3
—
—
—
0
0
5
17
2.99
1.36
1.4
2.9
5.4
3.0
nmol/l
—
5
17
11
54
2.09
1.35
1.5
1.8
—
—
—
0
0
190
1784
1.60
1.32
25.9
11.0
18.6
19.7
mg/l
0.24
170
1359
8
35
2.33
1.28
1.1
1.6
—
—
—
0
0
102
870
1.33
1.26
6.7
4.0
—
—
—
0
0
8
36
2.27
1.25
3.4
2.2
—
—
—
0
0
6
25
2.44
1.25
1.2
1.6
—
—
—
0
0
5
20
2.53
1.15
1.2
1.8
—
—
—
0
0
7
32
2.23
1.09
2.1
2.1
—
—
—
0
0
16
247
0.62
1.04
1.4
1.5
—
—
—
0
0
15
93
1.66
0.96
1.3
1.4
205.2
286.3
miu/ml
—
6
53
11
62
1.82
0.96
1.8
2.2
—
—
—
0
0
64
530
1.30
0.93
7.2
2.9
2.3
2.3
mmol/l
0.77
58
466
9
147
0.60
0.82
1.4
1.4
—
—
—
0
0
9
147
0.60
0.82
1.4
1.4
—
—
—
0
0
6
33
1.84
0.79
1.5
1.2
—
—
—
0
0
6
33
1.84
0.79
1.5
1.2
—
—
—
0
0
52
429
1.28
0.78
2.9
2.0
—
—
—
0
0
11
67
1.68
0.76
1.6
1.1
—
—
—
0
0
9
55
1.66
0.74
4.0
2.4
—
—
—
0
0
9
146
0.60
0.72
1.4
1.4
—
—
—
0
0
9
146
0.60
0.72
1.4
1.4
—
—
—
0
0
5
26
1.94
0.71
6.4
3.5
328.9
324.0
umol/l
—
5
21
5
26
1.94
0.71
1.2
1.1
—
—
—
0
0
172
1638
1.26
0.63
21.2
9.9
86.1
89.9
ml/min/173m2
0.97
150
1292
10
150
0.65
0.60
1.6
1.5
—
—
—
0
0
151
1422
1.21
0.60
3.7
3.8
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
5
90
0.54
0.57
1.2
1.7
—
—
—
0
0
12
169
0.69
0.54
1.3
1.4
—
—
—
0
0
10
66
1.54
0.53
1.4
1.2
—
—
—
0
0
53
462
1.20
0.49
4.6
3.5
0.0
0.0
estimate
0.50
16
173
20
156
1.31
0.47
7.1
5.2
—
—
—
0
0
17
130
1.33
0.45
1.5
1.3
—
—
—
0
0
55
485
1.18
0.45
1.6
1.6
—
—
—
0
0
5
31
1.63
0.43
1.0
1.1
—
—
—
0
0
8
56
1.45
0.43
1.5
1.4
—
—
—
0
0
8
56
1.45
0.43
1.1
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
16
125
1.30
0.38
1.1
1.0
—
—
—
0
0
6
43
1.41
0.35
1.3
1.2
—
—
—
0
0
167
1716
0.88
0.30
27.1
12.1
37.3
40.1
%
2.55
122
1385
6
81
0.73
0.24
1.5
1.5
—
—
—
0
0
14
115
1.23
0.24
1.9
1.8
—
—
—
0
0
168
1639
1.12
0.24
5.4
3.8
7.9
5.7
mmol/l
13.53
159
1515
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
30
274
1.11
0.16
2.8
2.6
2.5
2.4
mmol/l
1.22
24
235
44
411
1.09
0.16
2.3
2.0
—
—
—
0
0
7
90
0.77
0.14
2.0
2.0
—
—
—
0
0
39
366
1.08
0.13
2.2
1.9
—
—
—
0
0
43
453
0.94
0.11
1.5
1.5
—
—
—
0
0
5
48
1.04
0.09
2.6
2.6
36.1
38.4
g/l
—
5
42
10
92
1.09
0.03
1.5
1.4
—
—
—
0
0
26
251
1.04
0.03
1.8
1.9
—
—
—
0
0
18
188
0.95
0.02
1.8
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
14.5
—
0
5
7
77
0.91
0.00
1.7
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_NECROLIPOIDIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NECROLIPOIDIC | 1.708 [1.34, 2.18] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.1 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 716 females with L12_NECROLIPOIDIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NECROLIPOIDIC | 2.888 [1.87, 4.47] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.073 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 221 males with L12_NECROLIPOIDIC died.
Mortality risk
Mortality risk for people of age
years, who have L12_NECROLIPOIDIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.139% | 0.603% |
| 5 | 0.876% | 3.629% |
| 10 | 2.311% | 8.801% |
| 15 | 4.605% | 16.114% |
| 20 | 7.926% | 26.721% |
Relationships between endpoints
↥Index endpoint: L12_NECROLIPOIDIC – Necrobiosis lipoidica, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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