granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
217 |
4. Check minimum number of eventsNone |
217 |
5. Include endpointsNone |
217 |
6. Filter based on genotype QC (FinnGen only) |
211 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L92
- Name in latin
- Necrobiosis lipoidica non alibi classificata
Similar endpoints
↥List of similar endpoints to
Necrobiosis lipoidica, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1091 | 836 | 253 |
| Only index persons | 1019 | 789 | 230 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.63 | 46.08 | 48.41 |
| Only index persons | 45.18 | 44.62 | 47.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 211 | 162 | 49 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | 36.70 | 34.39 | 44.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 217
- Matched controls
- 2170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
+∞
294.6
210
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
38.1
149.2
107
54
A10AB01
ATC
insulin (human); parenteral
42.5
146.9
99
42
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
48.0
146.9
94
34
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
86.4
143.5
78
14
H04AA01
ATC
glucagon; nasal, parenteral
49.2
133.1
83
27
A10AB05
ATC
insulin aspart; parenteral
27.7
132.1
111
79
A10AE05
ATC
insulin detemir; parenteral
31.6
118.4
87
45
A10AE04
ATC
insulin glargine; parenteral
21.6
116.5
114
106
A10AC01
ATC
insulin (human); parenteral
21.6
116.1
113
104
A10AB04
ATC
insulin lispro; parenteral
31.4
113.7
83
42
A10AA01, ,
ATC
32.6
108.5
77
36
A10AA02, ,
ATC
31.7
107.3
77
37
T89
ICPC
Diabetes insulin dependent
24.3
104.2
86
57
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
32.5
101.1
71
32
103
Kela drug reimbursment
Diabetes, insulin-treated
15.2
93.4
147
264
215
Kela drug reimbursment
Diabetes, non-insulin-treated
14.8
92.3
143
251
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
55.7
82.5
48
11
A10AE06
ATC
insulin degludec; parenteral
23.5
80.5
64
38
E10
ICD-10 Finland
Type 1 diabetes mellitus
36.7
78.1
51
18
CKC12
NOMESCO Finland
Photocoagulation of retina
30.8
74.8
52
22
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
21.1
58.3
47
28
A10AD01
ATC
insulin (human); parenteral
27.9
57.7
41
18
SPAT1262
SPAT
Handing over of treatment supplies
8.9
55.6
96
177
XCK10
NOMESCO Finland
Photography of fundus of eye
10.4
52.1
70
95
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
22.1
51.2
40
22
H3603, E103,
ICD-10 Finland
258.8
42.5
42
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
10.3
41.6
53
66
S97
ICPC
Chronic ulcer skin
13.2
41.3
43
40
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
16.6
38.2
34
24
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
73.8
37.7
42
7
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
60.8
34.9
40
8
H3600, E103,
ICD-10 Finland
61.2
31.4
36
7
H3601, E103,
ICD-10 Finland
77.3
29.9
33
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.3
29.0
79
212
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
50.1
28.7
34
8
SPAT1148
SPAT
Treatment of chronic ulcer or burn
6.6
28.2
53
101
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
62.1
28.0
32
6
D07AD01
ATC
clobetasol; topical
5.2
27.1
72
188
H36.00
ICD-10 Finland
Diabetic background retinopathy
59.9
27.0
31
6
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
57.6
26.0
30
6
OAB50, ,
SPAT
9.6
26.0
33
40
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.7
25.2
39
60
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.7
24.9
45
82
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.0
24.6
51
106
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
98.0
24.2
26
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
268.4
24.2
24
*
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
38.4
24.1
30
9
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
35.4
22.1
28
9
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
4.0
19.6
74
247
C10AA01
ATC
simvastatin; oral
3.7
19.0
89
344
177
Kela drug reimbursment
Insulin glargine 300 U / ml
15.5
18.9
31
23
H36.01
ICD-10 Finland
Diabetic maculopathy
33.5
18.8
24
8
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
16.5
18.2
29
20
H43.1
ICD-10 Finland
Vitreous haemorrhage
40.5
18.0
22
6
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
103.7
17.9
19
*
J01FF01
ATC
clindamycin; systemic
3.5
17.5
91
372
E0000UV, ,
ATC
3.4
17.3
128
649
C10AA05
ATC
atorvastatin; oral
3.4
17.0
93
392
C10AX09
ATC
ezetimibe; oral
4.4
16.8
50
139
TQW80
NOMESCO Finland
Local dermatologic skincare
18.7
16.5
25
15
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
7.6
16.0
24
35
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.3
15.5
47
132
M65.3
ICD-10 Finland
Trigger finger
6.3
15.0
27
48
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
61.1
15.0
17
*
A10AA03, ,
ATC
23.1
15.0
21
10
L92.0
ICD-10 Finland
Granuloma annulare
86.1
14.8
16
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.3
14.8
43
117
H3602, E103,
ICD-10 Finland
160.3
14.6
15
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
14.4
109
544
D07AC01
ATC
betamethasone; topical
3.0
14.3
104
507
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.6
14.2
37
92
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
11.6
13.7
25
24
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
27.8
13.6
18
7
C10AA07
ATC
rosuvastatin; oral
3.1
13.4
78
333
171
Kela drug reimbursment
Degludekinsuliini
43.0
13.3
16
*
C03CA01
ATC
furosemide; systemic
3.3
13.1
64
246
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
21.7
12.7
18
9
XF600
NOMESCO Finland
Bloodpressure measurement
5.6
12.5
25
49
A46
ICD-10 Finland
Erysipelas
3.9
12.5
42
126
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
6.3
12.5
22
38
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
19.5
12.3
18
10
CKC15
NOMESCO Finland
Panretinal photocoagulation
49.6
12.0
14
*
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.2
12.0
58
221
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
20.3
11.8
17
9
CKD40
NOMESCO Finland
Endophotocoagulation of retina
20.3
11.8
17
9
C09AA02
ATC
enalapril; systemic
3.4
11.8
49
170
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.1
11.5
62
251
WZC30
NOMESCO Finland
Teaching
3.4
11.3
48
168
205
Kela drug reimbursment
Chronic hypertension
3.2
11.3
52
192
T90
ICPC
Diabetes non-insulin dependent
3.1
11.2
58
229
E000003, ,
ATC
5.6
11.0
22
43
A10BK01
ATC
dapagliflozin; oral
5.0
11.0
25
55
A10AB06
ATC
insulin glulisine; parenteral
29.8
10.9
14
5
TK800
NOMESCO Finland
Hemodialysis
22.9
10.8
15
7
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.0
10.8
57
227
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.2
10.5
11
550
Z94.0
ICD-10 Finland
Kidney transplant status
34.4
10.5
13
*
TPH04
NOMESCO Finland
Cathetrisation of vein
3.0
10.4
58
238
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
8.3
10.2
22
29
D07AC13
ATC
mometasone; topical
2.6
10.2
81
400
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
15.6
10.2
16
11
ZXA10
NOMESCO Finland
Bilateral
2.9
10.1
56
229
E000001, ,
ATC
2.8
10.0
66
296
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
4.3
9.9
27
69
XCD10
NOMESCO Finland
Electrophysiological examination of eye
9.1
9.8
20
24
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
5.2
9.8
21
44
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
57.6
9.7
11
*
127
Kela drug reimbursment
Transplant complication
18.6
9.5
14
8
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
31.6
9.5
12
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
31.6
9.5
12
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
31.6
9.5
12
*
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
104.4
9.5
10
*
ACC51
NOMESCO Finland
Release of median nerve
4.0
9.5
29
81
7098B
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Other specified disorders of skin[NECROBIOSIS LIPOIDICA]
+∞
9.4
9
*
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
9.7
9.2
18
20
ZZA00
NOMESCO Finland
Split skin graft
16.5
9.2
14
9
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
25.3
9.0
12
5
C09AA05
ATC
ramipril; oral
2.9
8.8
50
206
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
5.1
8.8
19
40
A10AD04
ATC
insulin lispro; parenteral
52.1
8.7
10
*
L04AD02
ATC
tacrolimus; systemic
52.1
8.7
10
*
S18
ICPC
Laceration/cut
2.4
8.7
103
602
B03XA02
ATC
darbepoetin alfa; parenteral
17.2
8.7
13
8
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.6
8.6
21
49
N18.8
ICD-10 Finland
Other chronic renal failure
21.1
8.6
12
6
J02AC01
ATC
fluconazole; systemic
2.3
8.5
117
728
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
+∞
8.4
8
*
MAX99
NOMESCO Finland
Assistance to normal delivery
0.0
8.4
*
231
Z96.4
ICD-10 Finland
Presence of endocrine implants
34.8
8.1
10
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.8
8.1
26
75
Z3229
NOMESCO Finland
Other healthcare associate professional
3.7
8.1
27
80
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
23.0
8.1
11
5
WX110
NOMESCO Finland
Infiltration anesthesia
2.7
8.1
174
1302
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.8
8.0
47
196
A63.0
ICD-10 Finland
Anogenital (venereal) warts
4.4
8.0
21
52
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
13.7
8.0
13
10
J01DA01
ATC
[U] cefalexin
2.4
7.9
151
1064
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.8
7.8
25
72
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
7.8
60
287
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
46.7
7.8
9
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
46.7
7.8
9
*
J01MA02
ATC
ciprofloxacin; systemic
2.3
7.7
89
509
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
26.1
7.6
10
*
A10BA02
ATC
metformin; oral
2.4
7.6
63
311
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.2
7.5
9
373
K08.3
ICD-10 Finland
Retained dental root
3.9
7.5
23
64
A12AA04
ATC
calcium carbonate; oral
14.0
7.5
12
9
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.8
7.5
41
165
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.7
7.4
44
185
ZXA05
NOMESCO Finland
Left side
2.5
7.3
58
280
L28.0
ICD-10 Finland
Lichen simplex chronicus
+∞
7.3
7
*
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
7.3
7
*
R4180
NOMESCO Finland
Podiatric therapy
16.5
7.3
11
7
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
16.5
7.3
11
7
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
7.3
67
346
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.3
7.2
19
47
V03AE01
ATC
polystyrene sulfonate; oral
31.1
7.2
9
*
N02AX02
ATC
tramadol; systemic, rectal
2.2
7.2
97
587
L04AA06
ATC
mycophenolic acid; systemic
12.6
7.2
12
10
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
7.2
37
144
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
7.4
7.1
16
23
XQ848
NOMESCO Finland
Dermatological photography
6.7
7.1
17
27
C08CA01
ATC
amlodipine; oral
2.3
6.9
71
383
MAA00
NOMESCO Finland
Amniocentesis
6.0
6.9
18
32
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
6.5
6.9
17
28
J01MA14
ATC
moxifloxacin; systemic
3.4
6.8
26
84
Z3231
NOMESCO Finland
Registered nurse
2.3
6.8
68
362
R11
ICD-10 Finland
Nausea and vomiting
3.1
6.8
31
112
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
41.4
6.8
8
*
TQB05
NOMESCO Finland
Puncture of skin of trunk
23.4
6.7
9
*
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.4
6.7
25
80
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
6.7
29
102
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
9.1
6.7
13
15
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
7.2
6.6
15
22
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
10.5
6.6
12
12
AA1AD
NOMESCO Finland
CT of head and brain
2.3
6.5
57
287
ZY010
NOMESCO Finland
Hospital outpatient
3.7
6.5
21
61
CL2L4
NOMESCO Finland
Wide-field fundus photography for diabetic retinopathy screening
71.9
6.5
7
*
D03BA52
ATC
collagenase, combinations; topical
71.9
6.5
7
*
D03BA02
ATC
collagenase; topical
71.9
6.5
7
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
71.9
6.5
7
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.9
6.5
15
23
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.5
6.4
23
72
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
7.4
6.3
14
20
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
18.7
6.3
9
5
XCH00
NOMESCO Finland
Eye pressure measurement
5.7
6.3
17
32
JLE03
NOMESCO Finland
Allogenic total transplantation of pancreas with pancreaticoenterostomy
+∞
6.3
6
*
QXA20
NOMESCO Finland
Skin abrasion, unspecified location
+∞
6.3
6
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
6.3
6
*
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
+∞
6.3
6
*
WX002
NOMESCO Finland
Sedation and analgesia
2.5
6.2
46
214
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.5
6.2
22
68
Z3232
NOMESCO Finland
Midwife
0.1
6.2
*
223
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.6
6.2
21
63
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
13.0
6.1
10
8
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.1
6.1
83
498
SPAT1229
SPAT
Assessment of need for aid
3.9
6.1
18
49
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
147
403
9.21
59.12
7.6
3.8
24.54
8.47
mg/mmol
1.69
117
248
142
452
7.20
46.34
6.5
2.9
6.85
7.60
mmol/l
1.33
133
389
32
26
14.26
33.12
2.9
2.4
224.66
183.73
ug/min
0.10
26
16
45
100
5.42
20.00
7.9
3.0
115.87
70.01
ng/l
1.72
39
91
102
447
3.42
17.59
2.1
1.6
1.35
1.38
mmol/l
0.13
92
399
106
490
3.27
16.50
1.7
1.3
2.09
1.01
u/ml
0.41
34
142
62
207
3.79
16.13
4.7
1.9
2.24
2.47
g/l
2.29
56
191
58
188
3.85
15.72
4.5
2.0
25.06
23.77
%
0.32
43
162
154
925
3.29
14.65
8.6
4.5
10.12
6.41
mmol/l
13.51
142
822
63
227
3.50
14.47
4.7
1.9
13.25
14.33
umol/l
0.52
57
208
129
750
2.78
12.13
3.7
2.2
69.64
75.60
nmol/l
1.71
120
684
61
244
3.09
11.56
2.0
1.6
1169.42
1115.02
nmol/l
0.20
52
180
114
637
2.66
11.39
11.5
4.1
34.06
36.78
g/l
4.80
105
599
22
48
4.99
9.77
2.4
2.5
1.46
1.34
g/l
0.19
22
43
29
83
3.88
9.16
3.5
2.2
-0.90
1.16
mmol/l
1.30
21
61
33
104
3.56
9.07
2.2
1.4
—
—
—
0
0
77
394
2.48
8.77
3.1
2.0
2.78
2.80
mg/l
0.03
70
337
22
53
4.51
8.68
1.9
1.4
259.53
313.11
ug/g
0.57
15
29
106
629
2.34
8.61
2.3
1.8
99.50
95.54
pmol/l
0.33
59
319
116
720
2.31
8.43
16.7
6.3
1.21
1.22
mmol/l
0.99
107
618
197
1564
3.82
8.42
14.2
4.6
56.65
38.42
mmol/mol
28.76
192
1475
76
395
2.42
8.30
3.9
2.6
319.45
3600.80
umol/l
1.32
71
355
18
40
4.82
7.80
1.6
1.2
—
—
—
0
0
36
132
3.07
7.74
5.9
11.1
1.28
1.18
mmol/l
0.06
29
102
21
54
4.20
7.63
5.2
2.2
0.71
0.66
%
0.21
21
54
88
506
2.24
7.46
7.0
2.5
55.63
54.48
u/l
0.06
82
461
38
151
2.84
7.07
8.3
6.6
103.39
104.43
mmol/l
0.72
38
151
12
14
9.00
6.14
1.9
1.3
—
—
—
0
0
17
35
5.18
5.88
2.2
1.2
—
—
—
0
0
48
234
2.35
5.85
2.1
1.7
—
—
—
0
0
95
608
2.00
5.75
15.7
8.5
1.32
1.14
inr
0.62
26
184
58
309
2.20
5.72
2.0
1.7
91667127.02
453.29
pmol/l
0.49
48
270
16
34
4.99
5.42
2.4
1.2
86.50
121.80
u/ml
—
6
5
37
167
2.47
5.32
1.2
1.3
129.11
144.28
iu/ml
0.14
21
73
27
105
2.79
5.20
3.0
2.9
69.77
79.93
ml/min/173m2
0.39
13
42
126
921
1.88
4.87
5.7
2.8
104.47
75.37
ug/l
1.30
117
859
82
529
1.88
4.64
3.6
3.0
49.95
29.40
ng/l
0.66
53
277
85
556
1.87
4.60
5.9
2.7
—
—
—
0
0
34
158
2.37
4.57
2.3
1.5
—
—
—
0
0
8
8
10.32
4.55
2.6
2.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
24
5.23
4.39
2.5
2.0
0.29
0.38
u/ml
—
5
11
15
39
4.05
4.29
1.7
1.1
—
—
—
0
0
5
210
0.22
4.26
1.8
1.6
—
—
—
0
0
37
184
2.22
4.25
4.0
2.5
3.90
6.05
umol/l
1.76
29
151
172
1422
2.01
4.23
5.9
4.2
14.78
14.50
pmol/l
0.73
165
1323
0
102
0.00
4.15
0.0
1.7
—
—
—
0
0
20
76
2.80
4.02
3.6
2.3
157.07
123.44
ng/l
0.14
14
71
33
162
2.22
3.91
2.3
1.5
—
—
—
0
0
55
337
1.85
3.54
1.3
1.3
16.12
9.10
u/ml
0.21
19
133
6
6
10.23
3.52
1.2
1.2
—
—
—
0
0
11
29
3.94
3.23
1.1
1.1
—
—
—
0
0
157
1307
1.73
3.21
5.0
3.7
14.74
9.66
mm/h
4.23
148
1216
129
1027
1.63
3.07
11.0
8.6
4.69
4.04
e9/l
2.87
118
901
5
5
10.19
2.99
1.4
1.0
110.80
109.20
%
—
5
5
12
37
3.37
2.98
2.5
1.4
—
—
—
0
0
7
13
5.52
2.89
1.1
1.0
—
—
—
0
0
29
153
2.03
2.87
5.6
2.3
25.75
28.52
u/l
0.22
24
133
54
352
1.71
2.78
1.4
1.3
11.06
25.49
iu/ml
2.29
14
113
28
148
2.02
2.76
1.3
2.3
15789.53
5169.16
u/l
—
9
63
10
29
3.56
2.73
1.2
1.1
—
—
—
0
0
39
237
1.79
2.55
4.5
2.6
7.33
3.39
e6/l
0.90
28
126
7
16
4.48
2.49
2.0
2.5
105.71
107.50
mmol/l
—
7
16
57
392
1.62
2.37
2.4
1.6
0.84
0.77
mg/l
0.14
46
291
7
18
3.98
2.27
1.0
1.1
—
—
—
0
0
15
67
2.33
2.23
1.3
1.3
—
—
—
0
0
6
14
4.37
2.16
1.0
1.4
—
—
—
0
0
6
15
4.08
2.05
1.2
1.3
—
—
—
0
0
17
84
2.11
2.02
2.1
1.5
—
—
—
0
0
40
266
1.62
1.89
4.9
3.1
166.43
236.70
ng/l
0.16
28
164
38
250
1.63
1.87
4.7
2.4
1.11
0.86
e6/l
0.28
29
139
26
154
1.78
1.86
4.6
2.9
—
—
—
0
0
17
87
2.04
1.85
1.7
1.4
—
—
—
0
0
107
879
1.43
1.83
7.2
4.4
0.00
0.00
estimate
-0.00
19
177
108
889
1.43
1.83
4.8
3.2
0.00
0.00
estimate
-0.00
20
186
108
893
1.42
1.76
4.9
3.2
0.00
0.00
estimate
-0.00
12
171
6
18
3.40
1.76
1.0
1.2
—
—
—
0
0
7
25
2.86
1.66
1.6
1.6
—
—
—
0
0
10
42
2.45
1.64
1.5
1.2
—
—
—
0
0
5
14
3.63
1.62
1.4
2.1
—
—
—
0
0
58
437
1.45
1.55
6.4
2.6
0.22
0.32
e6/l
0.47
52
321
7
27
2.64
1.53
1.3
1.7
—
—
—
0
0
47
343
1.47
1.48
2.7
2.7
1011.67
787.09
ng/l
0.30
39
285
194
1818
1.63
1.42
25.6
10.9
18.50
19.52
mg/l
0.22
173
1386
12
60
2.06
1.41
1.6
2.0
—
—
—
0
0
105
889
1.35
1.39
3.7
2.4
—
—
—
0
0
5
17
2.98
1.36
1.4
2.9
5.38
2.98
nmol/l
—
5
17
5
17
2.98
1.36
1.2
1.8
—
—
—
0
0
8
34
2.40
1.30
1.3
1.6
—
—
—
0
0
83
683
1.35
1.30
4.8
3.2
—
—
—
0
0
8
36
2.27
1.25
1.1
1.6
—
—
—
0
0
6
25
2.44
1.25
1.2
1.7
—
—
—
0
0
6
25
2.44
1.25
1.2
1.7
—
—
—
0
0
6
25
2.44
1.25
1.2
1.6
—
—
—
0
0
11
56
2.02
1.24
1.5
1.8
—
—
—
0
0
8
37
2.21
1.23
3.4
2.2
—
—
—
0
0
5
20
2.53
1.15
1.6
1.2
—
—
—
0
0
7
31
2.30
1.11
2.1
2.1
—
—
—
0
0
5
21
2.41
1.09
1.2
1.2
—
—
—
0
0
5
21
2.41
1.09
1.2
1.7
—
—
—
0
0
17
257
0.63
1.01
1.5
1.5
—
—
—
0
0
5
23
2.20
0.98
1.4
2.0
—
—
—
0
0
6
27
2.26
0.94
1.3
1.1
—
—
—
0
0
6
31
1.96
0.85
5.3
3.6
54.50
57.29
%
—
6
31
11
65
1.73
0.84
1.7
2.0
—
—
—
0
0
15
97
1.59
0.84
1.3
1.4
205.15
296.77
miu/ml
—
6
55
53
434
1.29
0.84
2.9
2.0
—
—
—
0
0
9
150
0.58
0.82
1.4
1.4
—
—
—
0
0
9
150
0.58
0.82
1.4
1.4
—
—
—
0
0
9
151
0.58
0.82
1.4
1.4
—
—
—
0
0
9
151
0.58
0.82
1.4
1.4
—
—
—
0
0
64
539
1.27
0.81
7.2
2.9
2.31
2.34
mmol/l
0.82
59
477
0
24
0.00
0.79
0.0
1.2
—
—
—
0
0
6
34
1.79
0.77
1.5
1.2
—
—
—
0
0
6
34
1.79
0.77
1.5
1.2
—
—
—
0
0
9
53
1.73
0.76
4.0
2.4
12.93
9.56
g/l
—
9
47
9
56
1.63
0.73
4.0
2.4
7.67
7.49
g/l
—
9
51
9
56
1.63
0.73
4.0
2.4
—
—
—
0
0
9
56
1.63
0.73
4.0
2.4
3.80
3.60
g/l
—
9
51
11
68
1.65
0.73
1.6
1.1
—
—
—
0
0
18
126
1.47
0.73
1.2
1.3
—
37.83
—
0
8
5
27
1.87
0.69
6.4
3.4
328.90
324.05
umol/l
—
5
21
155
1459
1.22
0.63
3.7
3.8
—
—
—
0
0
176
1679
1.26
0.62
21.0
9.7
86.28
90.06
ml/min/173m2
1.00
154
1333
5
30
1.68
0.62
1.0
1.1
—
—
—
0
0
8
54
1.50
0.58
4.4
2.4
2.65
3.00
g/l
—
8
49
5
90
0.55
0.57
1.2
1.6
—
—
—
0
0
11
156
0.69
0.52
1.5
1.5
—
—
—
0
0
10
67
1.52
0.50
1.4
1.1
—
—
—
0
0
57
500
1.19
0.49
1.6
1.6
—
—
—
0
0
17
131
1.32
0.43
1.5
1.3
—
—
—
0
0
8
59
1.37
0.41
1.5
1.4
—
—
—
0
0
8
59
1.37
0.41
1.1
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
20
160
1.28
0.40
7.1
5.2
—
—
—
0
0
53
472
1.16
0.39
4.6
3.5
0.00
0.01
estimate
0.50
16
177
16
127
1.28
0.34
1.1
1.0
—
—
—
0
0
6
45
1.34
0.34
1.3
1.2
—
—
—
0
0
14
176
0.78
0.33
1.3
1.5
—
—
—
0
0
15
121
1.26
0.29
1.9
1.8
—
—
—
0
0
31
275
1.15
0.25
2.7
2.6
2.48
2.42
mmol/l
1.35
25
235
7
91
0.76
0.23
2.0
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
46
426
1.10
0.19
2.2
2.0
—
—
—
0
0
43
460
0.92
0.16
1.5
1.5
—
—
—
0
0
170
1676
1.07
0.11
5.4
3.8
7.88
5.73
mmol/l
13.81
160
1550
40
379
1.07
0.10
2.2
1.9
—
—
—
0
0
7
84
0.83
0.07
1.7
1.5
—
—
—
0
0
27
257
1.06
0.06
1.9
1.9
—
—
—
0
0
10
92
1.09
0.03
1.5
1.4
—
—
—
0
0
205
2053
0.97
0.00
36.6
16.3
39.08
40.17
%
1.90
189
1942
19
192
0.99
0.00
1.8
1.8
—
—
—
0
0
7
77
0.91
-0.00
1.7
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
2.6
2.6
36.12
38.68
g/l
—
5
44
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
14.02
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint L12_NECROLIPOIDIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NECROLIPOIDIC | 1.708 [1.34, 2.18] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.1 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 716 females with L12_NECROLIPOIDIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NECROLIPOIDIC | 2.888 [1.87, 4.47] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.073 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 221 males with L12_NECROLIPOIDIC died.
Mortality risk
Mortality risk for people of age
years, who have L12_NECROLIPOIDIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.139% | 0.603% |
| 5 | 0.876% | 3.629% |
| 10 | 2.311% | 8.801% |
| 15 | 4.605% | 16.114% |
| 20 | 7.926% | 26.721% |
Relationships between endpoints
↥Index endpoint: L12_NECROLIPOIDIC – Necrobiosis lipoidica, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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