nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
201 |
4. Check minimum number of eventsNone |
201 |
5. Include endpointsNone |
201 |
6. Filter based on genotype QC (FinnGen only) |
201 |
Control definitions (FinnGen only)
- Control exclude
- N14_KIDUROTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N25-N29
- Name in latin
- Ren contractus non specificatus
Similar endpoints
↥List of similar endpoints to
Unspecified contracted kidney
based on the number of shared cases.
Similar with more cases:
- Other disorders of kidney and ureter
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2426 | 1203 | 1167 |
| Only index persons | 1486 | 779 | 707 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 65.34 | 65.36 | 65.15 |
| Only index persons | 61.79 | 61.91 | 61.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 201 | 91 | 110 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 55.88 | 53.90 | 57.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 180
- Matched controls
- 1801
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N26
ICD-10 Finland
Unspecified contracted kidney
+∞
191.5
148
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
31.8
62.1
85
49
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
44.4
45.8
56
18
N18.8
ICD-10 Finland
Other chronic renal failure
39.0
45.2
57
21
A11CC03
ATC
alfacalcidol; systemic
48.8
41.8
50
14
A12AA04
ATC
calcium carbonate; oral
76.9
33.5
37
6
137
Kela drug reimbursment
Uraemia requiring dialysis
138.7
32.9
34
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
31.7
31.9
42
17
Z94.0
ICD-10 Finland
Kidney transplant status
119.2
28.6
30
*
127
Kela drug reimbursment
Transplant complication
53.1
26.5
31
7
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
24.5
23
*
B05DA
ATC
Isotonic solutions
100.7
24.4
26
*
205
Kela drug reimbursment
Chronic hypertension
5.2
23.0
97
330
TK800
NOMESCO Finland
Hemodialysis
26.4
22.6
31
14
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
72.0
22.5
25
*
B03XA02
ATC
darbepoetin alfa; parenteral
27.3
20.7
28
12
L04AA06
ATC
mycophenolic acid; systemic
28.6
20.2
27
11
Z49.1
ICD-10 Finland
Extracorporeal dialysis
52.3
19.7
23
5
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
19.1
18
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
211.0
18.9
19
*
C03CA01
ATC
furosemide; systemic
4.4
18.6
90
332
Z49.2
ICD-10 Finland
Other dialysis
59.0
18.4
21
*
N18.0
ICD-10 Finland
End-stage renal disease
30.4
18.4
24
9
B05DB
ATC
Hypertonic solutions
74.4
18.1
20
*
5870A
ICD-9 Finland
Renal sclerosis, unspecified[SCLEROSIS RENALIS SECUNDARIA NUD]
+∞
18.0
17
*
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
9.8
17.0
35
43
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
99.4
16.9
18
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.2
16.4
38
57
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
52.7
16.4
19
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
66.2
16.1
18
*
M04AA01
ATC
allopurinol; systemic
5.2
15.5
53
133
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
39.7
14.7
18
5
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
162.6
14.7
15
*
TK820
NOMESCO Finland
Peritoneal dialysis
162.6
14.7
15
*
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
17.7
14.3
22
14
N19
ICD-10 Finland
Unspecified kidney failure
11.5
14.0
26
26
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
13.7
52
144
196
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
13.7
13
*
H05BX01
ATC
cinacalcet; oral
+∞
13.7
13
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
22.0
12.7
18
9
58499
ICD-8 Finland
Renal sclerosis, unqualified
+∞
12.6
12
*
V03AE03
ATC
lanthanum carbonate; oral
139.2
12.6
13
*
C08CA01
ATC
amlodipine; oral
3.2
12.3
90
425
L04AD01
ATC
ciclosporin; systemic
19.8
12.3
18
10
V03AE01
ATC
polystyrene sulfonate; oral
20.7
11.8
17
9
KBV00
NOMESCO Finland
Insertion of stent into ureter
127.8
11.6
12
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
19.3
10.9
16
9
Z49.0
ICD-10 Finland
Preparatory care for dialysis
23.2
10.9
15
7
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
63.9
10.8
12
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.7
10.5
24
35
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
25.1
10.4
14
6
B03XA01
ATC
erythropoietin; parenteral
58.2
9.8
11
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
8.3
9.7
21
28
H02AB04
ATC
methylprednisolone; systemic
3.7
9.4
43
139
C07AB02
ATC
metoprolol; systemic
3.2
9.2
56
222
L04AA01
ATC
[U] ciclosporin; systemic
16.7
9.2
14
9
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.9
9.2
39
118
C09AA02
ATC
enalapril; systemic
3.2
9.0
53
207
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
52.6
8.8
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
8.7
34
95
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
8.5
74
369
C02AC05
ATC
moxonidine; oral
7.7
8.5
19
27
ED1AA
NOMESCO Finland
Mandipular X-ray examination
94.2
8.5
9
*
N28.9
ICD-10 Finland
Disorder of kidney and ureter, unspecified
+∞
8.4
8
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
8.4
8
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
8.2
44
158
TPX10
NOMESCO Finland
Implantation of vascular injection port
9.6
8.2
16
18
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
23.3
8.1
11
5
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
13.9
8.0
13
10
I10
ICD-10 Finland
Essential (primary) hypertension
2.5
8.0
119
786
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.0
7.9
32
92
R50.9
ICD-10 Finland
Fever, unspecified
3.3
7.8
42
152
C08CA13
ATC
lercanidipine; oral
3.5
7.7
37
123
Q60.3
ICD-10 Finland
Renal hypoplasia, unilateral
83.3
7.5
8
*
V03AE02
ATC
sevelamer; oral
83.3
7.5
8
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
7.3
7
*
7151
FHL
Kidney transplantation
+∞
7.3
7
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
+∞
7.3
7
*
59000
ICD-8 Finland
Infections of kidney, Pyelonephritis chronica
+∞
7.3
7
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
31.4
7.2
9
*
I15.0
ICD-10 Finland
Renovascular hypertension
21.0
7.2
10
5
U14
ICPC
Kidney symptom/complaint
14.5
7.0
11
8
C08CA02
ATC
felodipine; oral
3.8
6.9
29
87
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
6.8
90
544
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
41.6
6.8
8
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.7
6.8
53
244
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
18.8
6.3
9
5
UKC02
NOMESCO Finland
Cystoscopy
2.8
6.3
42
175
PC5CG
NOMESCO Finland
Extensive MRI examination of kidney vasculature with high intensity magnet
+∞
6.3
6
*
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
+∞
6.3
6
*
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
+∞
6.3
6
*
N13.7
ICD-10 Finland
Vesicoureteral-reflux-associated uropathy
+∞
6.3
6
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
6.3
6
*
M01AH05
ATC
etoricoxib; oral
0.4
6.2
41
744
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.4
6.1
21
52
WW500
NOMESCO Finland
Blood transfusion
6.4
6.1
15
25
M01AE01
ATC
ibuprofen; systemic, rectal
0.4
6.1
100
1326
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
80
107
11.76
61.28
8.8
3.1
167.6
70.2
ng/l
4.51
73
95
77
209
5.35
28.06
8.7
2.1
23.5
22.0
%
0.42
71
175
30
32
10.84
25.96
11.5
7.2
343.6
150.5
iu/ml
—
5
6
50
103
6.13
24.49
9.3
4.5
0.6
1.6
mmol/l
0.96
33
78
139
687
4.32
21.51
20.0
5.3
1.2
1.2
mmol/l
0.33
130
625
121
544
4.08
21.46
10.0
3.2
—
—
—
0
0
144
740
4.34
20.82
24.4
6.2
1.2
1.2
mmol/l
2.34
123
639
24
28
9.60
19.30
6.7
2.9
16.4
15.9
%
0.23
24
14
24
29
9.26
18.79
2.0
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
27
38
8.05
18.72
2.9
2.3
0.3
0.4
u/ml
0.27
16
21
44
109
4.89
17.19
5.6
3.1
32.1
61.5
ml/min/173m2
8.33
31
46
50
138
4.49
17.08
4.8
3.3
—
—
—
0
0
103
473
3.42
16.54
8.7
4.0
45.1
10.0
mg/mmol
2.42
87
296
125
656
3.39
15.91
15.0
4.3
34.8
35.8
g/l
1.18
120
613
25
41
6.82
15.05
1.6
4.2
—
3.8
—
0
6
50
153
4.02
14.74
8.9
3.4
0.3
2.0
mmol/l
2.72
36
115
25
42
6.66
14.71
1.6
4.2
40.3
31.7
mg/l
0.29
17
35
25
42
6.66
14.71
1.6
4.2
51.0
79.0
mg/l
0.41
17
35
21
29
7.97
14.69
1.8
1.1
252.6
235.9
u/ml
0.05
15
18
15
13
12.39
14.59
1.1
1.2
—
—
—
0
0
93
430
3.16
14.30
8.3
3.1
0.1
0.4
e6/l
2.58
84
328
39
102
4.50
14.12
2.0
1.6
—
—
—
0
0
21
31
7.45
13.86
1.8
1.2
—
—
—
0
0
98
499
2.88
12.23
7.3
3.3
2.3
2.4
mmol/l
0.26
92
426
112
614
2.86
12.12
4.1
2.2
76.3
76.6
nmol/l
0.04
106
538
16
20
8.61
12.05
2.4
4.2
56.8
57.9
%
0.10
16
20
48
166
3.48
11.64
5.9
6.7
-0.5
1.1
mmol/l
1.41
31
135
15
18
8.92
11.64
1.1
1.1
—
—
—
0
0
112
630
2.76
11.29
8.0
2.5
228.6
121.9
ug/l
3.35
106
570
15
19
8.45
11.16
1.0
1.3
—
—
—
0
0
12
13
9.75
9.97
2.6
1.4
—
—
—
0
0
81
409
2.64
9.82
10.4
3.9
0.0
0.0
estimate
0.00
35
135
9
0
+∞
9.44
6.4
0.0
—
—
—
0
0
14
20
7.45
9.41
1.7
3.3
4.3
4.4
e9/l
0.06
14
20
61
272
2.78
9.39
2.4
1.6
1638.2
1191.6
nmol/l
1.80
51
208
144
986
2.62
8.80
9.2
4.2
22.2
227.9
e6/l
—
5
19
56
252
2.69
8.37
2.3
2.0
—
—
—
0
0
118
751
2.38
8.26
11.1
5.1
0.0
0.0
estimate
0.00
43
140
10
11
9.51
8.15
1.1
1.1
—
—
—
0
0
117
751
2.34
7.91
9.2
3.7
0.0
0.0
estimate
0.00
41
143
78
421
2.39
7.89
6.7
2.7
409.6
8696.8
umol/l
2.44
70
354
118
761
2.33
7.88
9.2
3.7
0.0
0.0
estimate
0.00
43
137
18
41
4.72
7.60
1.4
1.3
—
—
—
0
0
19
47
4.36
7.26
3.2
1.4
—
—
—
0
0
98
600
2.24
7.22
9.3
3.8
—
—
—
0
0
85
493
2.25
7.13
3.6
2.4
63.6
54.9
u/l
1.63
80
454
52
246
2.50
6.91
6.3
2.8
1.1
2.7
e6/l
1.40
34
139
79
455
2.21
6.65
3.4
3.5
7131.3
1196.5
ng/l
2.09
69
377
6
0
+∞
6.28
21.5
0.0
198.2
—
e6/l
—
6
0
105
687
2.11
6.27
6.5
4.2
—
—
—
0
0
64
360
2.14
5.56
4.0
2.4
—
—
—
0
0
51
264
2.25
5.43
4.4
2.7
0.7
1.0
e6/l
0.51
31
156
38
174
2.46
5.33
1.6
1.8
—
—
—
0
0
38
175
2.44
5.26
1.7
1.9
—
—
—
0
0
5
0
+∞
5.23
1.6
0.0
—
—
—
0
0
5
0
+∞
5.23
8.2
0.0
—
—
—
0
0
153
1198
2.16
5.18
16.8
7.5
95.0
79.8
u/l
2.11
146
1106
16
47
3.61
4.86
1.5
1.9
—
—
—
0
0
20
69
3.11
4.76
2.4
2.1
40.4
40.2
u/l
0.01
20
62
124
927
1.88
4.46
13.7
9.7
4.7
4.1
e9/l
1.99
111
813
32
147
2.40
4.44
2.8
2.3
0.2
0.2
g/l
0.68
32
140
23
96
2.58
3.89
8.4
7.3
0.8
0.7
%
0.53
23
96
23
96
2.58
3.89
8.4
7.1
1.3
1.5
%
0.39
23
96
22
92
2.56
3.71
1.9
1.4
—
—
—
0
0
53
319
1.90
3.66
1.9
1.7
444.5
441.2
pmol/l
0.03
47
270
10
26
4.00
3.56
3.5
1.8
—
—
—
0
0
14
49
3.00
3.26
2.4
1.2
—
—
—
0
0
75
517
1.72
3.26
3.8
3.2
60.8
33.2
u/l
0.44
70
485
80
568
1.68
3.09
2.2
1.9
102.3
93.1
pmol/l
0.97
44
281
12
40
3.13
3.02
3.5
1.7
—
—
—
0
0
7
13
5.53
2.89
1.1
1.5
—
—
—
0
0
11
38
3.00
2.62
4.2
1.7
—
—
—
0
0
84
625
1.59
2.60
5.1
3.9
68.2
37.1
ng/l
0.83
73
430
8
20
4.12
2.59
1.1
1.4
—
—
—
0
0
14
56
2.61
2.59
2.1
2.3
—
—
—
0
0
173
1547
1.85
2.39
35.5
14.4
21.8
23.2
mg/l
0.30
157
1204
52
350
1.66
2.38
1.7
1.5
19.4
21.1
nmol/l
0.31
45
288
5
8
6.37
2.38
1.2
2.9
906.0
682.3
u/ml
—
5
8
7
17
4.23
2.38
1.7
1.9
—
—
—
0
0
8
23
3.58
2.29
1.1
1.5
—
—
—
0
0
8
23
3.58
2.29
2.8
2.0
—
—
—
0
0
5
9
5.66
2.22
1.4
1.6
—
—
—
0
0
5
9
5.66
2.22
3.4
2.2
—
—
—
0
0
5
9
5.66
2.22
1.4
1.6
—
—
—
0
0
18
89
2.12
2.13
4.1
3.0
4.1
4.5
pmol/l
0.88
18
75
5
10
5.10
2.08
1.4
1.6
—
—
—
0
0
5
10
5.10
2.08
1.4
1.6
—
—
—
0
0
7
20
3.59
2.07
1.7
1.8
—
—
—
0
0
14
63
2.31
2.06
3.5
2.1
—
—
—
0
0
8
28
2.93
1.88
1.6
1.7
—
—
—
0
0
5
12
4.24
1.83
1.0
1.1
—
—
—
0
0
5
12
4.24
1.83
1.0
2.4
—
—
—
0
0
13
60
2.25
1.82
1.6
1.9
—
—
—
0
0
8
29
2.83
1.81
1.8
1.3
—
—
—
0
0
30
450
0.61
1.73
3.0
4.5
20.3
21.0
%
0.14
18
219
12
55
2.26
1.71
1.4
2.5
9.8
9.9
g/l
0.01
12
47
6
19
3.22
1.67
1.2
1.7
—
—
—
0
0
11
49
2.32
1.67
1.5
2.7
34.0
38.0
g/l
1.05
11
41
5
14
3.63
1.62
2.6
4.1
18.5
53.9
u/ml
—
5
14
5
14
3.63
1.62
1.0
1.2
—
—
—
0
0
26
164
1.67
1.52
4.0
4.5
9.5
9.4
ug/l
0.01
21
135
12
58
2.14
1.52
1.4
2.4
—
—
—
0
0
6
21
2.91
1.51
1.0
1.8
—
—
—
0
0
39
275
1.52
1.46
3.8
3.6
251.3
169.8
ng/l
0.23
30
213
5
16
3.18
1.44
1.8
1.4
—
—
—
0
0
6
22
2.78
1.44
1.2
1.1
—
—
—
0
0
11
53
2.14
1.41
1.5
2.6
3.8
3.2
g/l
0.64
11
42
5
17
2.99
1.36
3.4
3.6
—
—
—
0
0
46
341
1.45
1.35
2.9
1.9
1.5
1.4
mg/l
0.15
36
267
11
55
2.06
1.30
1.9
1.5
—
—
—
0
0
7
145
0.46
1.26
2.3
1.7
—
—
—
0
0
9
45
2.05
1.25
2.1
1.4
—
—
—
0
0
5
19
2.67
1.22
2.0
1.7
—
—
—
0
0
130
1157
1.35
1.22
5.8
4.1
20.7
11.5
mm/h
5.14
123
1051
10
50
2.05
1.18
1.4
2.7
—
—
—
0
0
38
279
1.45
1.17
4.2
2.9
2.5
2.5
mmol/l
0.08
32
243
5
20
2.54
1.16
2.0
1.7
—
—
—
0
0
5
20
2.54
1.16
2.0
1.7
—
—
—
0
0
5
20
2.54
1.16
2.0
1.7
—
—
—
0
0
8
40
2.04
1.13
1.1
1.2
—
—
—
0
0
10
51
2.01
1.13
3.3
1.6
0.0
0.0
iu/ml
—
5
13
7
31
2.30
1.11
1.9
1.4
—
—
—
0
0
7
31
2.30
1.11
1.9
1.4
—
—
—
0
0
5
21
2.41
1.09
2.0
1.7
—
—
—
0
0
5
21
2.41
1.09
2.0
1.7
—
—
—
0
0
7
35
2.04
1.01
1.3
1.5
—
—
—
0
0
0
30
0.00
0.98
0.0
1.6
—
—
—
0
0
6
30
2.03
0.87
1.0
1.3
—
—
—
0
0
6
31
1.96
0.85
1.3
1.4
—
—
—
0
0
153
1428
1.30
0.82
8.6
5.9
39.7
39.9
mmol/mol
0.08
148
1333
6
32
1.90
0.82
1.0
1.5
7.7
216.7
e6/l
—
6
23
8
48
1.69
0.79
1.4
1.3
—
—
—
0
0
8
48
1.69
0.79
1.4
1.3
—
—
—
0
0
21
149
1.46
0.79
2.0
2.0
—
—
—
0
0
153
1431
1.29
0.79
33.1
13.4
53.4
81.1
ml/min/173m2
18.83
137
1156
25
184
1.41
0.78
16.5
7.5
—
—
—
0
0
6
34
1.79
0.77
2.2
1.6
—
—
—
0
0
14
93
1.54
0.71
1.7
1.8
—
—
—
0
0
11
76
1.47
0.49
3.0
2.1
—
—
—
0
0
21
167
1.29
0.44
2.1
2.2
—
—
—
0
0
11
81
1.38
0.37
1.1
1.0
—
—
—
0
0
44
388
1.17
0.37
1.5
1.7
1.6
1.3
mmol/l
1.04
39
318
152
1467
1.15
0.33
6.4
4.0
1.5
1.3
mmol/l
3.45
144
1343
169
1647
1.16
0.29
21.3
10.5
30.6
26.4
u/l
0.51
164
1586
12
95
1.28
0.27
1.5
1.3
70.0
145.3
iu/ml
—
7
36
9
74
1.23
0.25
6.0
3.4
21.3
2094.6
u/ml
—
9
61
144
1400
1.10
0.21
32.2
15.1
36.7
40.1
%
3.75
91
1032
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.26
0.20
1.2
1.1
—
14.9
—
0
7
27
299
0.89
0.18
1.6
1.5
—
—
—
0
0
23
207
1.13
0.15
1.5
1.4
—
—
—
0
0
117
1140
1.06
0.13
5.1
3.8
14.8
14.7
pmol/l
0.09
111
1019
15
134
1.13
0.11
1.8
2.5
9.3
14.5
nmol/l
1.70
15
128
156
1541
1.06
0.08
7.0
5.1
2.5
2.7
mmol/l
3.41
145
1410
100
980
1.04
0.07
2.8
3.0
—
—
—
0
0
9
86
1.05
0.07
1.3
1.3
—
—
—
0
0
153
1513
1.05
0.07
6.8
4.6
4.4
4.6
mmol/l
2.81
144
1400
23
244
0.94
0.07
1.3
1.3
2.3
8.0
u/ml
—
8
95
152
1507
1.04
0.04
6.8
4.5
1.3
1.5
mmol/l
2.63
143
1381
140
1390
1.02
0.02
5.7
4.6
1.9
2.0
mu/l
0.31
135
1261
37
379
0.97
0.02
1.4
1.3
0.9
1.8
u/ml
0.65
12
88
25
253
0.99
0.00
1.2
1.3
17.8
37.4
iu/ml
—
9
87
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
9.8
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
6
67
0.89
0.00
2.8
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
66.5
—
0
5
56
560
1.00
0.00
4.3
5.0
1.3
2.6
ug/l
1.67
50
497
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
1.8
1.3
25.9
22.5
iu/l
—
5
45
5
56
0.89
0.00
2.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_UNSPECKIDCONTR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_UNSPECKIDCONTR | 2.593 [2.02, 3.33] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.521 |
During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 605 females with N14_UNSPECKIDCONTR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_UNSPECKIDCONTR | 2.537 [1.95, 3.3] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 572 males with N14_UNSPECKIDCONTR died.
Mortality risk
Mortality risk for people of age
years, who have N14_UNSPECKIDCONTR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.242% | 0.652% |
| 5 | 1.628% | 3.302% |
| 10 | 4.228% | 8.142% |
| 15 | 7.901% | 14.549% |
| 20 | 13.33% | 24.081% |
Relationships between endpoints
↥Index endpoint: N14_UNSPECKIDCONTR – Unspecified contracted kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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