nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
209 |
4. Check minimum number of eventsNone |
209 |
5. Include endpointsNone |
209 |
6. Filter based on genotype QC (FinnGen only) |
202 |
Control definitions (FinnGen only)
- Control exclude
- N14_KIDUROTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- N25-N29
- Name in latin
- Ren contractus non specificatus
Similar endpoints
↥List of similar endpoints to
Unspecified contracted kidney
based on the number of shared cases.
Similar with more cases:
- Other disorders of kidney and ureter
- All kidney diseases
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2426 | 1203 | 1167 |
| Only index persons | 1486 | 779 | 707 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 65.34 | 65.36 | 65.15 |
| Only index persons | 61.79 | 61.91 | 61.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 202 | 90 | 112 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 56.45 | 54.42 | 58.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 209
- Matched controls
- 2090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N26
ICD-10 Finland
Unspecified contracted kidney
+∞
229.9
176
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
32.7
130.0
98
55
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
64.0
110.2
63
14
N18.8
ICD-10 Finland
Other chronic renal failure
52.0
108.0
65
18
A11CC03
ATC
alfacalcidol; systemic
57.0
99.2
58
14
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
50.2
83.6
50
13
A12AA04
ATC
calcium carbonate; oral
57.1
77.7
45
10
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
10.3
39.3
50
62
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
10.8
38.2
46
53
137
Kela drug reimbursment
Uraemia requiring dialysis
148.9
36.0
37
*
Z94.0
ICD-10 Finland
Kidney transplant status
216.1
36.0
36
*
127
Kela drug reimbursment
Transplant complication
55.8
31.8
37
8
205
Kela drug reimbursment
Chronic hypertension
5.0
29.8
108
369
TK800
NOMESCO Finland
Hemodialysis
31.6
29.7
39
15
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.8
27.2
62
142
N18.0
ICD-10 Finland
End-stage renal disease
69.6
26.8
30
5
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
154.1
26.3
27
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
58.0
26.0
30
6
L04AA06
ATC
mycophenolic acid; systemic
30.9
25.8
34
13
N19
ICD-10 Finland
Unspecified kidney failure
10.4
25.4
30
33
B05DA
ATC
Isotonic solutions
102.9
25.3
27
*
B05DB
ATC
Hypertonic solutions
102.9
25.3
27
*
L04AD02
ATC
tacrolimus; systemic
102.9
25.3
27
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
47.8
24.3
29
7
B03XA02
ATC
darbepoetin alfa; parenteral
22.3
23.5
34
18
Z49.2
ICD-10 Finland
Other dialysis
94.3
23.2
25
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
59.0
22.7
26
5
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
22.3
21
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
244.5
22.0
22
*
M04AA01
ATC
allopurinol; systemic
4.7
20.6
60
166
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
8.7
20.0
27
35
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
116.1
19.9
21
*
C03CA01
ATC
furosemide; systemic
3.6
18.5
104
452
H05BX01
ATC
cinacalcet; oral
73.3
18.1
20
*
5870A
ICD-9 Finland
Renal sclerosis, unspecified[SCLEROSIS RENALIS SECUNDARIA NUD]
+∞
18.0
17
*
TK820
NOMESCO Finland
Peritoneal dialysis
104.0
17.9
19
*
V03AE01
ATC
polystyrene sulfonate; oral
26.9
17.8
24
10
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
16.8
17.7
28
19
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
55.0
17.3
20
*
KBV00
NOMESCO Finland
Insertion of stent into ureter
69.3
17.0
19
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
38.6
17.0
21
6
196
Kela drug reimbursment
Paricalcitol and cinacalcet
98.1
16.8
18
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.2
16.4
52
152
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.1
16.2
26
41
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
172.4
15.7
16
*
C02AC05
ATC
moxonidine; oral
7.0
15.4
25
40
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
86.3
14.8
16
*
U14
ICPC
Kidney symptom/complaint
29.6
14.6
19
7
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
46.0
14.3
17
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
46.0
14.3
17
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
15.0
14.1
23
17
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
57.4
14.0
16
*
H02AB04
ATC
methylprednisolone; systemic
3.7
13.8
52
170
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
13.7
13
*
58499
ICD-8 Finland
Renal sclerosis, unqualified
+∞
13.7
13
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
30.6
13.2
17
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.8
12.8
45
140
R50.9
ICD-10 Finland
Fever, unspecified
3.5
12.8
54
190
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.4
12.8
56
202
C08CA01
ATC
amlodipine; oral
2.8
12.3
104
542
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.2
12.3
27
58
V03AE03
ATC
lanthanum carbonate; oral
49.7
12.0
14
*
C08CA02
ATC
felodipine; oral
4.2
12.0
35
95
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
68.9
11.7
13
*
V03AE02
ATC
sevelamer; oral
126.7
11.5
12
*
204
Kela drug reimbursment
Leukemia lymphatica
13.9
10.9
18
14
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
29.8
10.9
14
5
L04AD01
ATC
ciclosporin; systemic
13.0
10.6
18
15
Q60.3
ICD-10 Finland
Renal hypoplasia, unilateral
+∞
10.5
10
*
N18.4
ICD-10 Finland
Chronic kidney disease, stage 4
34.5
10.5
13
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.9
10.4
34
100
I15.0
ICD-10 Finland
Renovascular hypertension
42.2
10.1
12
*
L04AA01
ATC
[U] ciclosporin
21.3
9.9
14
7
C07AB02
ATC
metoprolol; systemic
2.8
9.9
63
278
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
104.6
9.5
10
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.3
9.5
26
67
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.7
9.4
33
102
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
9.3
114
686
N18
ICD-10 Finland
Chronic kidney disease
16.6
9.2
14
9
B03XA01
ATC
erythropoietin; parenteral
16.6
9.2
14
9
321
Kela drug reimbursment
Paricalcitol and cinacalcet
38.5
9.1
11
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
7.4
9.1
21
31
UKC02
NOMESCO Finland
Cystoscopy
3.0
9.0
47
185
N18.3
ICD-10 Finland
Chronic kidney disease, stage 3
13.4
9.0
15
12
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
8.9
37
127
C09AA02
ATC
enalapril; systemic
2.7
8.7
60
274
WW500
NOMESCO Finland
Blood transfusion
4.6
8.4
21
50
I10
ICD-10 Finland
Essential (primary) hypertension
2.4
8.4
141
959
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
+∞
8.4
8
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
8.4
8
*
PBL09
NOMESCO Finland
Construction of arteriovenous fistula from brachial artery
46.8
7.8
9
*
59000
ICD-8 Finland
Infections of kidney, Pyelonephritis chronica
46.8
7.8
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
7.6
81
449
M10.9
ICD-10 Finland
Gout, unspecified
3.9
7.5
23
64
M01AE01
ATC
ibuprofen; systemic, rectal
0.4
7.5
119
1567
Z2446
NOMESCO Finland
Social worker
3.7
7.5
25
74
B01AB10
ATC
tinzaparin; parenteral
3.3
7.5
31
106
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
82.9
7.5
8
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
7.5
60
293
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
+∞
7.3
7
*
PC5CG
NOMESCO Finland
Extensive MRI examination of kidney vasculature with high intensity magnet
+∞
7.3
7
*
N13.7
ICD-10 Finland
Vesicoureteral-reflux-associated uropathy
+∞
7.3
7
*
KAC00
NOMESCO Finland
Nephrectomy
+∞
7.3
7
*
7151
FHL
Kidney transplantation
+∞
7.3
7
*
I12.9
ICD-10 Finland
Hypertensive renal disease without renal failure
+∞
7.3
7
*
C08CA13
ATC
lercanidipine; oral
2.8
7.3
42
174
N28.9
ICD-10 Finland
Disorder of kidney and ureter, unspecified
31.2
7.2
9
*
TK810
NOMESCO Finland
Hemofiltration
31.2
7.2
9
*
K65.0
ICD-10 Finland
Acute peritonitis
12.6
7.2
12
10
KAC11
NOMESCO Finland
Total nephrectomy with capsule, transcutaneous
41.4
6.8
8
*
XPX08
NOMESCO Finland
Intraoperative flow measurement
41.4
6.8
8
*
C07AB07
ATC
bisoprolol; oral
2.1
6.8
112
732
A41.9
ICD-10 Finland
Sepsis, unspecified
4.4
6.7
17
41
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.3
6.7
27
91
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.5
6.7
24
75
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.3
6.6
65
345
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
72.0
6.5
7
*
3025
Kela drug reimbursment
Calcium carbonate
72.0
6.5
7
*
N13.0
ICD-10 Finland
Hydronephrosis with ureteropelvic junction obstruction
72.0
6.5
7
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
72.0
6.5
7
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.9
6.5
17
31
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.6
6.4
41
178
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
11.5
6.4
11
10
M01AH05
ATC
etoricoxib; oral
0.4
6.4
52
903
SPAT1262
SPAT
Handing over of treatment supplies
2.5
6.3
45
206
I15.9
ICD-10 Finland
Secondary hypertension, unspecified
18.7
6.3
9
5
ED1AA
NOMESCO Finland
Mandibular X-ray examination
18.7
6.3
9
5
Q60.0
ICD-10 Finland
Renal agenesis, unilateral
+∞
6.3
6
*
R4190
NOMESCO Finland
Nutritional therapy
5.5
6.2
17
33
C07AG02
ATC
carvedilol; oral
3.4
6.1
23
74
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
85
114
11.88
65.08
8.8
3.1
168.74
73.01
ng/l
4.65
76
101
82
221
5.46
30.24
9.2
2.1
23.24
21.89
%
0.38
76
186
35
41
10.05
28.37
8.1
2.6
22.84
25.61
mmol/l
2.15
35
41
31
33
10.86
26.86
11.8
7.0
378.00
150.50
iu/ml
—
6
6
53
107
6.30
26.56
8.9
4.4
0.65
1.61
mmol/l
0.86
35
82
35
47
8.74
25.43
7.1
5.1
8.73
8.59
kpa
0.17
35
47
127
575
4.08
22.27
9.9
3.2
—
—
—
0
0
145
726
4.26
21.81
20.9
5.4
1.21
1.21
mmol/l
0.23
139
665
151
783
4.35
21.47
25.2
6.3
1.19
1.21
mmol/l
2.67
130
682
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
30
41
8.38
21.37
3.2
2.2
0.29
0.35
u/ml
0.34
18
21
53
143
4.63
18.69
5.0
3.4
—
—
—
0
0
47
115
4.98
18.67
5.2
3.0
32.41
62.02
ml/min/173m2
8.73
34
47
108
495
3.45
17.44
8.7
3.9
43.82
10.11
mg/mmol
2.43
91
312
107
496
3.37
16.81
10.0
3.2
30.08
172.64
e6/l
0.56
100
383
107
500
3.34
16.52
7.0
3.1
5.87
7.95
mmol/l
5.18
99
418
27
44
6.90
16.37
2.4
4.0
—
3.85
—
0
6
131
695
3.37
16.27
15.3
4.3
34.73
35.72
g/l
1.27
126
651
27
45
6.74
16.02
2.4
4.0
39.09
31.78
mg/l
0.25
18
37
27
45
6.74
16.02
2.4
4.0
62.43
78.22
mg/l
0.20
18
37
99
455
3.23
15.49
8.0
3.1
0.14
0.37
e6/l
2.68
89
346
52
164
3.89
14.63
9.1
3.4
0.22
1.88
mmol/l
2.74
39
125
26
28
10.44
13.43
6.3
3.0
16.33
15.69
%
0.29
26
14
40
111
4.22
13.35
2.0
1.5
—
—
—
0
0
118
640
2.94
13.19
4.0
2.2
76.74
76.57
nmol/l
0.02
111
561
52
176
3.60
13.09
5.7
7.2
11.29
11.75
kpa
0.34
47
170
103
523
2.91
12.97
7.2
3.2
2.34
2.36
mmol/l
0.47
97
456
52
178
3.56
12.85
5.7
7.3
-0.21
0.96
mmol/l
0.93
34
144
119
655
2.90
12.83
8.3
2.5
227.48
124.34
ug/l
3.41
113
595
25
29
9.64
12.43
2.0
1.2
—
—
—
0
0
83
390
2.87
11.87
3.9
2.0
3.20
3.18
mg/l
0.03
78
343
86
427
2.72
10.90
10.3
4.0
0.00
0.00
estimate
-0.00
39
137
22
30
8.06
10.00
1.8
1.1
252.51
235.89
u/ml
0.05
15
18
65
295
2.75
9.65
2.5
1.6
1649.13
1186.44
nmol/l
2.01
54
226
22
32
7.55
9.61
1.8
1.2
—
—
—
0
0
16
13
13.21
9.53
1.2
1.2
—
—
—
0
0
151
1033
2.66
9.31
9.4
4.3
18.67
1128.25
e6/l
—
6
20
50
202
2.94
9.18
10.1
6.6
103.66
104.05
mmol/l
0.19
50
202
122
766
2.42
8.91
20.2
13.5
1.45
1.29
inr
0.91
43
218
83
439
2.48
8.89
6.6
2.8
411.19
8294.33
umol/l
2.43
75
372
59
266
2.70
8.78
2.3
2.0
—
—
—
0
0
124
788
2.41
8.76
11.0
5.0
0.00
0.00
estimate
-0.00
47
142
124
798
2.36
8.37
9.2
3.7
0.00
0.00
estimate
-0.00
47
140
123
789
2.36
8.36
9.2
3.7
0.00
0.00
estimate
-0.00
49
154
17
21
8.71
8.27
2.4
4.0
57.94
57.00
%
0.09
17
21
90
515
2.31
7.88
3.6
2.4
62.85
54.57
u/l
1.61
85
474
103
624
2.28
7.87
9.3
3.8
—
—
—
0
0
55
260
2.51
7.31
6.1
2.8
1.11
2.90
e6/l
1.66
35
146
11
7
16.48
7.31
1.1
1.0
123.27
165.95
mmol/24h
—
11
7
19
48
4.25
7.06
3.2
1.4
—
—
—
0
0
15
20
7.99
7.03
1.0
1.3
—
—
—
0
0
15
20
7.99
7.03
1.1
1.1
—
—
—
0
0
18
44
4.38
6.97
1.4
1.3
—
—
—
0
0
15
21
7.60
6.84
1.7
3.1
4.65
4.26
e9/l
0.19
15
21
110
715
2.14
6.74
4.2
2.7
—
—
—
0
0
83
484
2.19
6.72
3.4
3.4
6955.95
1205.85
ng/l
2.08
71
404
19
51
4.00
6.53
1.4
1.8
—
—
—
0
0
6
0
+∞
6.28
21.5
0.0
198.17
—
e6/l
—
6
0
12
14
9.01
6.14
2.5
1.4
—
—
—
0
0
161
1250
2.25
5.80
16.5
7.5
94.55
80.13
u/l
2.06
154
1158
54
279
2.26
5.77
4.2
2.7
0.68
1.01
e6/l
0.62
32
164
67
379
2.13
5.72
4.0
2.4
—
—
—
0
0
40
187
2.41
5.35
1.6
1.8
—
—
—
0
0
40
188
2.39
5.28
1.6
1.9
—
—
—
0
0
5
0
+∞
5.23
8.2
0.0
—
—
—
0
0
5
0
+∞
5.23
1.6
0.0
—
—
—
0
0
10
12
8.68
5.12
1.1
1.1
—
—
—
0
0
130
969
1.90
4.76
13.8
9.6
4.64
4.07
e9/l
1.87
115
847
20
71
3.01
4.53
2.3
2.1
40.41
39.62
u/l
0.05
20
63
25
102
2.65
4.41
8.0
8.0
1.31
1.45
%
0.46
25
102
25
102
2.65
4.41
8.0
8.2
0.82
0.72
%
0.74
25
102
57
331
1.99
4.41
1.9
1.8
438.16
443.49
pmol/l
0.05
50
282
7
7
10.29
4.04
1.0
1.3
73.71
23.10
u/l
—
7
7
7
7
10.29
4.04
1.0
1.3
163.57
91.30
u/l
—
7
7
32
154
2.27
3.98
2.8
2.3
0.24
0.22
g/l
0.63
32
143
23
97
2.54
3.81
2.0
1.4
—
—
—
0
0
59
369
1.83
3.58
1.7
1.5
18.98
20.62
nmol/l
0.35
51
303
8
13
6.35
3.53
1.1
1.5
—
—
—
0
0
86
603
1.72
3.53
2.2
1.9
102.25
92.68
pmol/l
1.11
47
303
13
42
3.23
3.43
3.3
1.6
—
—
—
0
0
78
539
1.71
3.34
3.7
3.2
59.05
33.65
u/l
0.42
73
504
11
28
4.09
3.34
3.3
1.8
—
—
—
0
0
14
50
2.93
3.15
2.4
1.2
—
—
—
0
0
9
20
4.65
3.15
1.1
1.4
—
—
—
0
0
20
89
2.38
2.97
3.9
3.0
4.10
4.48
pmol/l
0.95
20
75
89
658
1.61
2.85
5.2
3.9
66.94
40.48
ng/l
0.71
78
461
12
40
3.12
2.74
3.9
1.6
—
—
—
0
0
8
19
4.33
2.70
1.6
1.8
—
—
—
0
0
9
24
3.87
2.70
1.1
1.5
—
—
—
0
0
14
56
2.61
2.59
2.1
2.3
—
—
—
0
0
5
7
7.28
2.56
1.0
1.9
—
—
—
0
0
6
11
5.58
2.56
8.5
2.0
—
—
—
0
0
14
57
2.56
2.50
4.6
3.4
4.26
4.05
mmol/l
0.47
14
57
15
64
2.45
2.45
3.3
2.1
—
—
—
0
0
180
1614
1.83
2.39
36.3
14.5
22.06
23.90
mg/l
0.43
164
1261
8
22
3.74
2.39
1.6
1.7
—
—
—
0
0
5
8
6.37
2.38
1.2
2.9
906.00
682.25
u/ml
—
5
8
5
8
6.37
2.38
1.0
1.8
—
—
—
0
0
5
8
6.37
2.38
1.0
1.8
—
—
—
0
0
8
24
3.42
2.20
2.8
2.0
—
—
—
0
0
14
61
2.39
2.20
1.6
1.8
—
—
—
0
0
9
30
3.09
2.17
1.6
1.6
—
—
—
0
0
9
31
2.99
2.10
1.7
1.3
—
—
—
0
0
5
10
5.09
2.08
1.4
1.5
—
—
—
0
0
5
10
5.09
2.08
1.4
1.5
—
—
—
0
0
50
353
1.55
1.85
2.7
1.8
1.56
1.46
mg/l
0.12
39
276
5
12
4.24
1.83
1.0
1.1
—
—
—
0
0
5
12
4.24
1.83
1.4
1.5
—
—
—
0
0
5
12
4.24
1.83
1.4
1.5
—
—
—
0
0
7
23
3.11
1.81
1.0
1.7
—
—
—
0
0
5
13
3.91
1.72
1.0
2.3
—
—
—
0
0
13
63
2.13
1.63
2.5
2.3
—
—
—
0
0
5
14
3.63
1.62
1.0
1.2
—
—
—
0
0
6
20
3.06
1.59
1.0
1.7
—
—
—
0
0
137
1198
1.42
1.58
5.7
4.1
20.98
11.67
mm/h
5.47
129
1089
33
474
0.64
1.56
3.0
4.5
20.64
20.98
%
0.06
20
231
5
15
3.39
1.53
2.6
4.1
18.52
54.33
u/ml
—
5
15
5
16
3.17
1.44
1.8
1.4
—
—
—
0
0
11
53
2.14
1.41
2.6
1.6
0.01
0.00
iu/ml
—
5
14
6
23
2.65
1.37
1.2
1.1
—
—
—
0
0
5
17
2.99
1.36
3.4
3.6
—
—
—
0
0
9
45
2.04
1.25
2.1
1.4
—
—
—
0
0
11
56
2.02
1.24
1.9
1.5
—
—
—
0
0
10
49
2.09
1.24
1.5
1.4
360.20
286.15
ug/g
—
5
29
26
174
1.56
1.22
4.0
4.5
9.51
33.17
ug/l
0.47
21
144
15
86
1.80
1.22
1.2
1.2
440.25
440.34
u/ml
0.00
15
81
8
151
0.51
1.20
2.1
1.7
—
—
—
0
0
40
296
1.43
1.18
4.1
2.9
2.46
2.45
mmol/l
0.15
34
260
5
20
2.54
1.16
2.0
1.7
—
—
—
0
0
161
1484
1.37
1.11
8.7
5.9
39.68
39.97
mmol/mol
0.16
156
1386
8
41
1.99
1.10
1.1
1.2
—
—
—
0
0
5
21
2.41
1.09
2.0
1.7
—
—
—
0
0
5
21
2.41
1.09
2.0
1.7
—
—
—
0
0
5
21
2.41
1.09
2.0
1.7
—
—
—
0
0
10
52
1.97
1.08
1.4
2.6
—
—
—
0
0
39
293
1.41
1.07
3.8
3.7
251.30
167.74
ng/l
0.23
30
230
7
33
2.16
1.06
1.9
1.4
—
—
—
0
0
7
33
2.16
1.06
1.9
1.4
—
—
—
0
0
7
33
2.16
1.06
1.0
1.3
—
—
—
0
0
5
22
2.30
1.04
2.0
1.6
—
—
—
0
0
5
22
2.30
1.04
2.0
1.6
—
—
—
0
0
7
35
2.03
1.01
1.3
1.5
—
—
—
0
0
161
1493
1.34
0.99
33.6
13.6
52.77
80.99
ml/min/173m2
20.47
143
1210
0
30
0.00
0.98
0.0
1.6
—
—
—
0
0
22
150
1.52
0.98
1.9
2.0
—
—
—
0
0
26
191
1.41
0.82
16.0
7.7
—
—
—
0
0
15
99
1.55
0.78
1.7
1.8
—
—
—
0
0
6
34
1.79
0.77
1.3
1.4
—
—
—
0
0
6
34
1.79
0.77
1.0
1.5
7.67
277.12
e6/l
—
6
25
5
29
1.74
0.64
6.8
1.7
—
—
—
0
0
5
29
1.74
0.64
6.8
1.7
—
—
—
0
0
8
52
1.56
0.60
1.4
1.3
—
—
—
0
0
8
52
1.56
0.60
1.4
1.3
—
—
—
0
0
6
35
1.73
0.58
2.2
1.6
—
—
—
0
0
22
169
1.34
0.56
2.0
2.2
—
—
—
0
0
160
1522
1.22
0.55
6.5
4.1
1.51
1.27
mmol/l
3.32
151
1395
11
77
1.45
0.46
2.7
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
200.02
—
0
18
177
1716
1.21
0.40
21.2
10.6
30.31
26.40
u/l
0.49
171
1653
11
84
1.33
0.30
1.1
1.0
—
—
—
0
0
45
404
1.15
0.30
1.6
1.7
1.61
1.37
mmol/l
0.83
40
333
183
1791
1.18
0.28
54.8
21.2
37.87
40.34
%
5.73
169
1682
12
97
1.25
0.23
1.5
1.3
69.97
141.70
iu/ml
—
7
37
164
1601
1.11
0.22
7.1
5.1
2.44
2.74
mmol/l
3.98
153
1468
161
1571
1.11
0.22
6.9
4.6
4.34
4.62
mmol/l
2.97
152
1457
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
122
1179
1.08
0.20
5.1
3.8
14.74
14.74
pmol/l
0.00
115
1053
6
51
1.18
0.19
1.2
1.1
—
14.90
—
0
7
160
1564
1.10
0.19
6.9
4.5
1.35
1.45
mmol/l
2.37
151
1436
6
53
1.14
0.19
1.7
1.3
22.23
22.45
iu/l
—
6
45
105
1011
1.08
0.18
2.8
3.0
—
—
—
0
0
9
79
1.15
0.15
6.0
3.2
21.33
1938.95
u/ml
—
9
66
23
208
1.12
0.14
1.5
1.4
—
—
—
0
0
28
304
0.91
0.14
1.6
1.5
—
—
—
0
0
37
392
0.93
0.11
1.4
1.3
0.93
1.76
u/ml
0.65
12
91
146
1447
1.03
0.04
5.7
4.5
1.89
1.98
mu/l
0.39
141
1314
60
590
1.02
0.02
4.1
4.9
1.36
2.57
ug/l
1.47
54
525
24
248
0.96
0.02
1.3
1.3
2.26
8.50
u/ml
—
8
96
153
1536
0.99
0.00
7.3
4.6
5.98
5.98
mmol/l
0.00
148
1400
26
261
1.00
0.00
1.2
1.3
17.52
37.20
iu/ml
—
10
88
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
6
68
0.88
-0.00
2.8
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
90
1.00
-0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
66.52
—
0
5
0
8
0.00
-0.00
0.0
1.3
—
9.80
—
0
8
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
57
0.87
-0.00
2.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint N14_UNSPECKIDCONTR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_UNSPECKIDCONTR | 2.593 [2.02, 3.33] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.521 |
During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 605 females with N14_UNSPECKIDCONTR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_UNSPECKIDCONTR | 2.537 [1.95, 3.3] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 233 out of 572 males with N14_UNSPECKIDCONTR died.
Mortality risk
Mortality risk for people of age
years, who have N14_UNSPECKIDCONTR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.242% | 0.652% |
| 5 | 1.628% | 3.302% |
| 10 | 4.228% | 8.142% |
| 15 | 7.901% | 14.549% |
| 20 | 13.33% | 24.081% |
Relationships between endpoints
↥Index endpoint: N14_UNSPECKIDCONTR – Unspecified contracted kidney
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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