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Congenital lens malformations

DOID EFO Endpoint Browser PheWeb

Q17_CONGEN_LENS_MALFO

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — Q12
  • Cause of death: ICD-10 — Q12

2 out of 7 registries used, show all original rules.

184

4. Check minimum number of events

None

184

5. Include endpoints

None

184

6. Filter based on genotype QC (FinnGen only)

175

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_EYE_EAR_FACE_NECK

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q1
Name in latin
Malformationes congenitae lentis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2183 1150 1030
Only index persons 1768 928 840
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 10.95 12.13 9.56
Only index persons 18.23 19.68 16.63

-FinnGen-

Key figures

All Female Male
Number of individuals 175 110 65
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 35.00 35.21 34.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
184
Matched controls
1840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q12.0
ICD-10 Finland
Congenital cataract
+∞
225.3
167
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
15.9
68.0
71
70
H27.0
ICD-10 Finland
Aphakia
388.0
33.0
32
*
H26.4
ICD-10 Finland
After-cataract
10.6
31.3
38
44
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
5.5
29.3
91
279
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.6
27.3
71
185
CJB10
NOMESCO Finland
Laser discission of secondary cataract
9.5
24.7
32
40
S01ED51
ATC
timolol, combinations; ophthalmic
8.8
21.9
30
40
CKD60
NOMESCO Finland
Anterior vitrectomy
124.2
21.1
22
*
114
Kela drug reimbursment
Glaucoma
8.3
21.0
30
42
7433A
ICD-9 Finland
Congenital anomalies of eye, Congenital cataract and lens anomalies
+∞
19.1
18
*
ZXA00
NOMESCO Finland
Right side
4.1
18.1
68
229
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
70.1
17.1
19
*
74439
ICD-8 Finland
Congenital anomalies of eye, Cataracta NUD
186.2
16.8
17
*
H26.00
ICD-10 Finland
Infantile, juvenile and presenile cataract
+∞
14.8
14
*
WX140
NOMESCO Finland
Parabulbar anesthesy
13.6
14.6
25
21
S01ED01
ATC
timolol; ophthalmic
17.7
14.3
22
14
TCG10
NOMESCO Finland
Removal of sutures from cornea
+∞
13.7
13
*
XCK10
NOMESCO Finland
Photography of fundus of eye
5.2
13.7
31
69
XCD00
NOMESCO Finland
Clinical examination of eye in general anaesthesia
139.1
12.6
13
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.4
11.9
34
91
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
32.4
11.8
15
5
CJD20
NOMESCO Finland
Extracapsular cataract extraction with implantation of artificial lens in posterior chamber
+∞
11.6
11
*
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
+∞
11.6
11
*
Q12.1
ICD-10 Finland
Congenital displaced lens
+∞
11.6
11
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
37.6
11.4
14
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.3
11.2
53
201
S01EE01
ATC
latanoprost; ophthalmic
8.9
11.0
23
29
H26.02
ICD-10 Finland
Presenil cataract
19.3
10.9
16
9
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
116.4
10.5
11
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.2
10.5
31
85
ZXD10
NOMESCO Finland
Scheduled procedure
2.8
10.2
82
415
H53.0
ICD-10 Finland
Amblyopia ex anopsia
18.0
10.1
15
9
H33.0
ICD-10 Finland
Retinal detachment with retinal break
12.4
9.8
17
15
H26.01
ICD-10 Finland
Infantile, juvenile and presenile cataract
58.1
9.8
11
*
ZXA10
NOMESCO Finland
Bilateral
3.1
9.7
49
192
H27.1
ICD-10 Finland
Dislocation of lens
105.2
9.5
10
*
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
23.2
9.5
13
6
ZXA05
NOMESCO Finland
Left side
2.9
8.9
51
213
S01EC01
ATC
acetazolamide; systemic
13.7
8.5
14
11
S01EC03
ATC
dorzolamide; ophthalmic
+∞
8.4
8
*
S01BA04
ATC
prednisolone; ophthalmic
15.4
8.3
13
9
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
8.3
59
276
H50.1
ICD-10 Finland
Divergent concomitant strabismus
26.3
7.7
10
*
S01EA03
ATC
apraclonidine; ophthalmic
26.3
7.7
10
*
ZXD20
NOMESCO Finland
Day surgery
3.1
7.6
35
128
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
21.0
7.2
10
5
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.2
7.2
32
115
H52.1
ICD-10 Finland
Myopia
4.5
6.7
17
41
S01EC04
ATC
brinzolamide; ophthalmic
7.0
6.5
15
23
S01AX11
ATC
[U] ofloxacin
7.0
6.5
15
23
ZXE00
NOMESCO Finland
One hour or less
2.2
6.3
83
501
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
6.3
6
*
H54.4
ICD-10 Finland
Blindness, monocular
+∞
6.3
6
*
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
+∞
6.3
6
*
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
+∞
6.3
6
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
27.7
6.3
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
6.2
69
389
S01EA05
ATC
brimonidine; ophthalmic
13.1
6.2
10
8
Z2446
NOMESCO Finland
Social worker
3.4
6.1
23
74
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
7.7
6.0
13
18

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
61
372
1.96
4.17
5.2
3.6
7.39
7.40
ph
0.29
11
69
78
519
1.87
4.09
6.4
4.7
35.37
36.80
g/l
1.16
70
494
57
346
1.94
3.92
3.9
4.3
94.89
94.39
%
0.05
57
339
87
623
1.75
3.43
12.1
7.1
1.22
1.22
mmol/l
0.31
75
531
38
209
2.03
3.42
2.6
3.0
2.45
2.44
mmol/l
0.25
32
186
50
304
1.89
3.37
5.4
3.9
—
—
—
0
0
80
568
1.72
3.19
9.7
6.6
1.22
1.22
mmol/l
0.08
75
522
31
167
2.03
2.94
2.1
1.6
—
—
—
0
0
5
6
8.52
2.76
1.4
1.2
—
—
—
0
0
101
788
1.62
2.66
9.0
6.6
1.83
1.92
e9/l
0.73
94
701
100
779
1.62
2.65
8.8
7.0
0.19
0.18
e9/l
0.08
92
684
30
167
1.95
2.60
2.3
4.6
23.48
8.01
umol/l
0.40
24
146
5
7
7.30
2.56
1.4
2.0
—
—
—
0
0
6
11
5.60
2.56
1.2
1.1
13.92
20.15
umol/l
—
6
11
97
755
1.60
2.54
8.2
6.7
0.59
0.55
e9/l
0.99
88
653
97
757
1.60
2.50
8.2
6.7
0.04
0.04
e9/l
0.05
88
654
21
104
2.15
2.48
4.1
10.6
24.52
25.25
mmol/l
0.45
21
104
100
788
1.59
2.46
9.1
4.6
6.53
6.42
mmol/l
0.21
91
713
60
419
1.64
2.43
4.4
3.4
2.37
2.37
mmol/l
0.08
55
374
109
882
1.58
2.36
11.7
10.0
4.37
3.94
e9/l
0.62
98
757
92
721
1.55
2.26
9.2
7.1
—
—
—
0
0
70
516
1.58
2.25
13.8
9.4
1.03
1.14
inr
1.57
21
158
8
25
3.30
2.12
5.5
3.3
9.86
8.82
kpa
—
8
25
8
25
3.30
2.12
5.5
3.3
5.16
5.04
kpa
—
8
25
5
10
5.10
2.08
3.0
20.4
13.00
12.14
%
—
5
10
7
20
3.60
2.07
5.6
3.1
—
—
—
0
0
126
1073
1.55
2.03
7.5
6.9
86.59
81.03
u/l
0.30
119
1004
5
11
4.64
1.95
1.6
1.3
—
—
—
0
0
22
124
1.88
1.86
8.2
8.8
—
—
—
0
0
56
408
1.54
1.84
2.9
2.7
—
—
—
0
0
38
253
1.63
1.83
1.6
1.4
21.67
21.83
nmol/l
0.02
32
217
61
457
1.50
1.76
2.2
1.7
99.56
95.93
pmol/l
0.30
27
242
165
1520
1.83
1.72
17.1
11.6
27.57
19.93
mg/l
1.58
139
1156
6
19
3.23
1.67
1.2
1.4
0.32
0.31
g/l
—
6
13
6
19
3.23
1.67
1.2
1.4
5.10
6.61
g/l
—
6
14
6
19
3.23
1.67
1.2
1.4
2.32
2.22
g/l
—
6
13
6
19
3.23
1.67
1.2
1.4
—
—
—
0
0
7
25
2.87
1.66
2.9
9.7
—
—
—
0
0
29
185
1.67
1.64
2.2
2.7
30.30
29.58
s
0.28
29
180
123
1066
1.46
1.63
4.3
4.2
10.54
9.19
mm/h
0.65
115
985
132
1161
1.48
1.61
4.0
3.8
14.70
14.64
pmol/l
0.10
122
1055
39
270
1.56
1.60
3.7
2.7
507.55
545.32
mosm/kgh2o
0.52
33
233
6
20
3.06
1.59
2.7
11.2
74.67
65.08
%
—
6
20
20
117
1.80
1.52
1.2
1.3
152.40
152.75
iu/ml
—
10
42
52
388
1.47
1.51
4.1
2.7
—
—
—
0
0
11
52
2.19
1.47
15.3
7.0
—
—
—
0
0
40
285
1.52
1.44
4.0
2.5
6.80
5.34
e6/l
0.48
33
252
52
392
1.46
1.43
7.2
7.5
—
—
—
0
0
36
252
1.53
1.41
1.2
1.3
61.49
35.03
iu/ml
—
8
77
14
76
1.91
1.34
1.9
3.1
23.10
8.07
ug/l
—
9
67
22
138
1.67
1.33
5.5
3.1
—
—
—
0
0
16
92
1.81
1.30
2.0
2.7
11327.11
3404.97
u/l
—
9
34
51
390
1.43
1.29
4.1
2.7
0.12
0.30
e6/l
1.77
38
281
0
33
0.00
1.17
0.0
1.1
—
—
—
0
0
34
245
1.48
1.17
2.0
1.6
—
—
—
0
0
81
680
1.34
1.15
5.4
6.5
20.53
11.22
umol/l
0.66
75
645
7
30
2.38
1.13
3.0
3.3
3.36
4.90
e9/l
—
7
30
7
30
2.38
1.13
3.0
4.0
58.00
60.53
%
—
7
30
12
66
1.88
1.12
7.1
3.2
211.42
197.30
ng/l
0.05
12
60
15
89
1.75
1.11
4.9
3.1
80.72
71.46
e9/l
—
10
74
5
21
2.42
1.10
1.2
1.9
285.80
282.36
mosm/kgh2o
—
5
14
51
401
1.38
1.09
3.5
3.0
8.17
8.13
mmol/l
0.02
42
354
7
32
2.23
1.09
1.0
2.4
—
—
—
0
0
30
215
1.47
1.06
6.3
3.8
2889.20
135.09
ng/l
0.47
24
139
137
1252
1.37
1.05
4.8
4.9
38.32
38.45
mmol/mol
0.05
125
1173
85
726
1.32
1.05
10.7
8.8
0.00
0.00
e9/l
0.56
65
582
50
396
1.36
1.02
1.4
1.5
1.84
2.21
g/l
0.99
32
228
20
137
1.52
0.88
6.8
8.5
104.85
104.08
mmol/l
0.32
20
137
52
424
1.32
0.87
4.7
3.0
15.18
52.60
e6/l
1.50
39
317
61
512
1.29
0.83
4.7
3.6
115.99
38.16
e6/l
0.63
44
339
147
1382
1.32
0.75
5.0
4.4
1.89
1.85
mu/l
0.17
139
1273
5
24
2.11
0.75
8.4
2.5
—
—
—
0
0
166
1591
1.44
0.73
15.1
10.1
—
—
—
0
0
7
40
1.78
0.72
7.0
10.5
—
—
—
0
0
10
61
1.68
0.70
10.1
3.3
—
—
—
0
0
39
316
1.30
0.69
1.8
2.3
0.92
1.31
mg/l
0.52
26
254
42
345
1.28
0.67
2.0
1.7
—
—
—
0
0
24
182
1.37
0.65
2.6
1.8
—
—
—
0
0
98
888
1.22
0.65
4.1
3.4
—
—
—
0
0
25
192
1.35
0.63
1.9
1.6
1244.93
1247.98
nmol/l
0.00
14
149
5
30
1.68
0.62
3.0
1.5
—
—
—
0
0
39
321
1.27
0.61
3.9
3.2
29.71
66.78
mg/l
1.25
29
208
0
21
0.00
0.60
0.0
2.1
—
1.34
—
0
15
0
21
0.00
0.60
0.0
2.0
—
—
—
0
0
18
132
1.40
0.59
1.2
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
3.4
—
1.35
—
0
22
0
22
0.00
0.59
0.0
2.0
—
587.20
—
0
15
8
53
1.53
0.59
1.9
2.1
—
—
—
0
0
40
333
1.26
0.58
5.1
3.8
3.86
11.14
mg/mmol
1.76
28
209
64
565
1.20
0.54
1.7
2.0
—
—
—
0
0
13
93
1.43
0.49
1.5
1.3
—
—
—
0
0
7
46
1.54
0.49
1.3
1.2
—
—
—
0
0
10
68
1.50
0.48
1.1
1.1
—
—
—
0
0
19
147
1.33
0.47
1.5
1.5
—
—
—
0
0
7
48
1.48
0.47
1.4
1.1
—
—
—
0
0
27
222
1.25
0.44
3.0
2.7
4.98
2.84
e6/l
0.50
13
117
28
232
1.24
0.43
2.5
2.5
313.00
99.19
ug/g
0.46
21
173
163
1582
1.27
0.41
11.3
9.2
27.07
26.15
u/l
0.27
154
1531
0
16
0.00
0.41
0.0
3.3
—
105.62
—
0
16
0
16
0.00
0.41
0.0
3.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
3.3
—
3.97
—
0
16
32
373
0.83
0.39
1.7
1.7
1.20
1.36
mmol/l
0.72
25
313
0
19
0.00
0.39
0.0
3.7
—
8.04
—
0
19
20
161
1.27
0.39
1.3
1.2
—
—
—
0
0
9
69
1.32
0.38
8.4
6.2
125.44
130.70
g/l
—
9
69
6
43
1.41
0.35
1.7
1.4
—
—
—
0
0
6
43
1.41
0.35
1.5
3.0
—
—
—
0
0
47
419
1.16
0.35
2.4
2.3
—
—
—
0
0
37
324
1.18
0.34
4.6
3.4
—
—
—
0
0
6
88
0.67
0.34
2.3
1.9
—
—
—
0
0
6
46
1.31
0.33
1.0
1.4
—
—
—
0
0
50
450
1.15
0.33
2.9
3.4
23.24
24.88
ng/l
0.11
32
274
10
74
1.37
0.33
1.1
1.1
—
—
—
0
0
6
47
1.29
0.32
1.0
1.2
—
—
—
0
0
105
996
1.13
0.31
5.5
4.1
—
—
—
0
0
10
75
1.35
0.31
1.1
1.7
—
—
—
0
0
45
407
1.14
0.28
2.7
2.2
55.95
57.65
u/l
0.09
40
380
8
64
1.26
0.28
3.1
6.3
0.63
0.69
%
—
8
64
49
447
1.13
0.27
2.4
2.0
—
—
—
0
0
11
86
1.30
0.27
7.2
6.1
—
—
—
0
0
5
73
0.68
0.26
2.2
2.1
—
—
—
0
0
13
106
1.24
0.24
7.8
5.5
5.27
5.11
kpa
0.34
13
101
5
39
1.29
0.23
1.0
1.3
—
—
—
0
0
19
163
1.18
0.22
1.5
1.5
—
—
—
0
0
43
394
1.12
0.22
6.3
3.7
0.00
0.00
estimate
-0.00
18
161
0
11
0.00
0.21
0.0
2.5
—
33045.91
—
0
11
0
11
0.00
0.21
0.0
3.1
—
263.33
—
0
6
0
11
0.00
0.21
0.0
4.0
—
2.76
—
0
11
0
10
0.00
0.21
0.0
4.0
—
1.28
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
175
1727
1.27
0.20
25.8
17.2
39.52
40.54
%
1.12
168
1652
9
114
0.78
0.20
2.2
2.3
—
29.63
—
0
8
19
165
1.17
0.20
1.2
1.9
—
—
—
0
0
6
50
1.21
0.20
1.5
1.6
—
—
—
0
0
24
213
1.15
0.19
1.3
1.5
200.00
421.60
titre
—
6
50
6
52
1.16
0.19
2.3
1.4
—
—
—
0
0
6
52
1.16
0.19
1.0
1.4
36.17
34.21
nmol/l
—
6
52
13
109
1.21
0.19
1.5
1.4
—
—
—
0
0
28
253
1.13
0.18
1.3
1.2
10.76
7.13
u/ml
—
10
100
20
177
1.15
0.17
1.3
1.2
—
—
—
0
0
13
150
0.86
0.15
2.6
2.5
0.86
0.71
ug/l
—
6
94
21
189
1.13
0.14
1.1
1.3
—
—
—
0
0
28
258
1.10
0.13
1.1
1.6
—
—
—
0
0
9
107
0.83
0.13
14.4
4.5
—
—
—
0
0
49
515
0.93
0.12
2.8
2.5
—
—
—
0
0
5
46
1.09
0.09
6.8
5.5
—
—
—
0
0
8
74
1.08
0.07
1.3
1.2
—
—
—
0
0
31
326
0.94
0.07
2.6
3.5
—
—
—
0
0
7
83
0.84
0.07
4.3
2.3
64.09
65.32
g/l
—
7
78
9
83
1.09
0.07
2.4
2.0
—
—
—
0
0
132
1303
1.05
0.07
3.8
3.6
1.31
1.25
mmol/l
0.39
120
1222
28
267
1.06
0.05
2.3
1.8
—
—
—
0
0
45
437
1.04
0.05
1.7
1.4
0.73
1.57
u/ml
0.81
12
110
135
1360
0.97
0.03
4.2
3.9
1.48
1.47
mmol/l
0.06
122
1280
71
719
0.98
0.02
6.6
4.5
0.00
0.00
estimate
-0.00
19
164
45
442
1.02
0.01
1.6
1.6
—
—
—
0
0
42
413
1.02
0.01
4.4
2.9
—
—
—
0
0
136
1353
1.02
0.01
3.9
3.9
5.97
5.75
mmol/l
0.71
124
1252
15
144
1.05
0.00
1.3
1.3
—
—
—
0
0
139
1384
1.02
0.00
4.5
4.2
2.83
2.79
mmol/l
0.22
129
1299
72
726
0.99
0.00
5.3
3.3
0.00
0.02
estimate
0.50
18
160
10
101
0.99
0.00
3.4
3.8
—
—
—
0
0
11
111
0.99
0.00
1.6
1.7
—
—
—
0
0
13
131
0.99
0.00
2.5
3.3
0.24
0.22
g/l
0.31
13
122
137
1369
1.00
0.00
4.1
3.9
4.73
4.66
mmol/l
0.39
125
1295
72
722
1.00
0.00
5.3
3.3
0.00
0.00
estimate
-0.00
19
171
12
117
1.03
0.00
1.6
1.7
—
—
—
0
0
12
117
1.03
0.00
1.6
1.7
—
—
—
0
0
12
117
1.03
0.00
1.6
1.6
—
—
—
0
0
12
118
1.02
0.00
1.6
1.7
—
—
—
0
0
15
155
0.96
0.00
1.4
1.2
—
—
—
0
0
11
108
1.02
0.00
1.1
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
5.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
13.2
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
62.87
—
0
8
6
69
0.87
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
7.27
—
0
7
9
98
0.91
-0.00
1.2
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
1.50
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
0.87
—
0
7
8
80
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
59
0.84
-0.00
6.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
16.42
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
51.00
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint Q17_CONGEN_LENS_MALFO and mortality.

Females

Parameter HR [95% CI] p-value
Q17_CONGEN_LENS_MALFO 1.84 [1.35, 2.5] < 0.001
Birth year 0.995 [0.99, 1.0] 0.26

During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 1030 females with Q17_CONGEN_LENS_MALFO died.

Males

Parameter HR [95% CI] p-value
Q17_CONGEN_LENS_MALFO 1.74 [1.29, 2.34] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 61 out of 909 males with Q17_CONGEN_LENS_MALFO died.

Mortality risk

Mortality risk for people of age

years, who have Q17_CONGEN_LENS_MALFO.

N-year risk Females Males
1 0.179% 0.298%
5 1.2% 1.783%
10 2.636% 4.544%
15 5.309% 8.245%
20 9.297% 13.429%

Relationships between endpoints

↥

Index endpoint: Q17_CONGEN_LENS_MALFO – Congenital lens malformations

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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