Magnesium deficiency

E4_MG_DEF

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E61.2#
  • Cause of death: ICD-10 E61.2#

2 out of 7 registries used, show all original rules.

98

4. Check minimum number of events

None

98

5. Include endpoints

None

98

6. Filter based on genotype QC (FinnGen only)

98

Control definitions (FinnGen only)

Control exclude
E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E61
Name in latin
Deficientia magnesii

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 425 193 228
Only index persons 408 188 220
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 65.03 66.98 63.78
Only index persons 65.36 67.07 63.90

-FinnGen-

Key figures

All Female Male
Number of individuals 98 48 50
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 66.32 67.47 65.22

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
86
Matched controls
860
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E61.2
ICD-10 Finland
Magnesium deficiency
+∞
123.8
86
*
E87.6
ICD-10 Finland
Hypokalaemia
42.7
22.2
27
9
E83.51
ICD-10 Finland
Hypocalcemia
240.3
19.4
19
*
N02AA05
ATC
oxycodone; systemic
8.8
14.5
34
59
A03FA01
ATC
metoclopramide; systemic, rectal
6.9
14.3
43
108
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.2
14.2
32
52
TPH04
NOMESCO Finland
Cathetrisation of vein
6.8
14.0
43
110
E83.4
ICD-10 Finland
Disorders of magnesium metabolism
+∞
13.9
13
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.5
13.8
37
78
R4190
NOMESCO Finland
Nutritional therapy
18.9
11.4
17
11
WW500
NOMESCO Finland
Blood transfusion
18.9
11.4
17
11
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
+∞
10.6
10
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
14.8
10.4
17
14
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
10.1
10.1
20
25
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
17.8
9.9
15
10
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
9.7
9.8
20
26
C03CA01
ATC
furosemide; systemic
4.8
9.6
39
127
130
Kela drug reimbursment
Malignant tumour
8.1
9.6
22
35
H02AB02
ATC
dexamethasone; systemic
6.2
9.2
26
56
ZX120
NOMESCO Finland
Intravenous
7.2
8.9
22
39
J18.9
ICD-10 Finland
Pneumonia, unspecified
4.9
8.9
33
97
R53
ICD-10 Finland
Malaise and fatigue
4.9
8.7
32
93
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
99.4
8.6
9
*
C03DA01
ATC
spironolactone; oral
6.3
8.4
23
47
R11
ICD-10 Finland
Nausea and vomiting
9.3
8.4
17
22
D64.9
ICD-10 Finland
Anaemia, unspecified
6.8
8.2
21
39
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
15.0
8.2
13
10
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
12.6
8.1
14
13
A02BC02
ATC
pantoprazole; systemic
4.4
7.9
71
444
AA1AD
NOMESCO Finland
CT of head and brain
4.1
7.9
36
128
R56.8
ICD-10 Finland
Other and unspecified convulsions
9.1
7.8
16
21
TPH07
NOMESCO Finland
Cathetrisation of artery
5.4
7.7
24
57
WX892
NOMESCO Finland
Monitored bed care
6.4
7.5
20
39
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
6.2
7.4
20
40
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
11.5
7.3
13
13
WF004
NOMESCO Finland
Palliative radiotherapy
33.1
7.3
9
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.7
7.3
40
163
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.6
7.2
44
193
XF600
NOMESCO Finland
Bloodpressure measurement
7.6
7.0
16
25
A01
ICPC
Pain general/multiple sites
7.6
7.0
16
25
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
5.4
7.0
21
48
K92.1
ICD-10 Finland
Melaena
9.1
6.9
14
18
JDB10
NOMESCO Finland
Percutaneous gastrostomy
18.6
6.9
10
6
Z51.5
ICD-10 Finland
Palliative care
8.0
6.9
15
22
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.7
6.9
35
133
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.4
6.7
54
287
UJF32
NOMESCO Finland
Coloscopy
3.6
6.6
35
137
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.8
6.6
31
111
J01MA12
ATC
levofloxacin; systemic
4.0
6.5
28
92
E86
ICD-10 Finland
Volume depletion
75.2
6.5
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.4
6.4
41
183
J01MA02
ATC
ciprofloxacin; systemic
3.2
6.4
47
234
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
29.0
6.3
8
*
103
Kela drug reimbursment
Diabetes, insulin-treated
3.5
6.2
35
141
JN3AD
NOMESCO Finland
Abdominal CT examination
6.8
6.2
15
26
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.2
6.1
24
73

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
67
100
19.02
50.31
9.0
7.2
1.0
1.0
mmol/l
0.59
67
94
42
64
10.73
29.07
9.0
8.9
—
—
—
0
0
42
64
10.73
29.07
5.7
4.9
2.6
2.2
mmol/l
0.17
37
48
74
230
10.05
26.46
8.5
4.6
—
—
—
0
0
41
68
9.65
26.23
5.3
4.8
—
—
—
0
0
93
419
24.85
25.24
20.6
7.6
1.2
1.2
mmol/l
2.81
79
360
45
88
8.61
24.79
4.8
2.4
403.2
382.9
nmol/l
0.26
40
83
39
66
9.15
24.36
4.2
4.3
103.1
91.4
ng/l
0.21
31
58
76
267
9.23
23.17
13.3
4.3
7.4
7.4
ph
0.20
13
42
32
45
10.07
23.16
5.6
5.7
25.0
25.5
mmol/l
0.28
32
45
61
180
7.33
22.01
3.2
1.8
3.0
3.4
mg/l
0.39
54
158
87
363
13.44
21.93
13.1
4.7
31.9
35.2
g/l
4.73
87
344
91
498
12.56
17.04
24.3
11.3
4.4
4.1
e9/l
0.52
78
435
67
267
5.77
15.91
10.1
5.8
—
—
—
0
0
49
163
5.01
14.18
5.1
2.4
534.9
551.9
mosm/kgh2o
0.20
41
137
83
421
7.35
14.17
10.3
5.8
0.7
0.6
e9/l
1.64
69
364
83
422
7.32
14.10
10.3
5.8
0.0
0.0
e9/l
0.07
69
365
84
433
7.58
14.00
10.3
5.8
1.7
1.8
e9/l
0.66
72
379
48
159
4.96
13.92
10.3
3.3
2.5
2.5
mmol/l
0.16
43
137
16
17
11.05
13.82
1.3
3.4
—
—
—
0
0
60
239
4.90
13.69
5.4
2.9
0.8
0.4
e6/l
0.55
45
171
84
438
7.42
13.67
10.6
6.2
0.2
0.2
e9/l
0.19
71
386
61
247
4.89
13.60
6.2
2.9
—
—
—
0
0
63
262
4.93
13.56
6.4
2.9
52.1
56.0
e6/l
0.04
48
195
58
229
4.76
13.29
5.4
2.7
—
—
—
0
0
65
280
4.92
13.28
4.4
2.3
—
—
—
0
0
22
38
7.18
12.91
3.0
2.6
1.5
1.2
%
0.34
22
38
32
80
5.45
12.87
1.3
1.8
—
—
—
0
0
27
61
5.73
12.09
10.8
8.1
94.4
93.8
%
0.25
27
61
36
107
4.74
11.68
9.3
7.7
-0.5
1.4
mmol/l
1.29
30
86
64
296
4.35
11.32
8.6
3.5
118.7
50.7
e6/l
0.82
48
202
65
319
4.08
10.23
3.4
1.9
80.7
99.1
pmol/l
1.45
43
140
67
337
4.12
10.14
11.7
6.7
1.2
1.2
inr
0.02
20
97
26
66
5.00
10.09
2.3
4.2
69.4
72.9
e9/l
0.18
20
50
51
214
3.88
10.09
19.0
8.0
—
—
—
0
0
45
174
3.93
10.02
3.8
2.2
3.9
4.4
e6/l
0.23
38
151
41
150
3.98
9.86
2.3
1.5
1081.4
1205.9
nmol/l
0.42
31
110
25
63
4.98
9.76
11.5
7.8
0.7
0.7
%
0.14
25
63
11
12
10.20
9.15
1.0
1.1
—
—
—
0
0
29
90
4.16
8.65
1.3
1.7
—
—
—
0
0
11
13
9.40
8.63
2.8
1.5
14.3
16.7
%
—
6
6
19
42
5.37
8.55
1.6
1.3
—
—
—
0
0
10
11
10.01
8.23
2.7
2.7
54.8
56.8
%
—
10
11
31
105
3.86
8.14
2.0
1.6
—
—
—
0
0
22
58
4.60
8.05
3.4
2.1
—
—
—
0
0
39
156
3.49
7.97
10.7
3.3
84.4
106.8
ng/l
0.18
34
130
23
64
4.39
7.86
12.3
7.8
1.2
1.7
%
0.94
23
64
10
12
9.17
7.72
4.2
1.4
4.8
5.3
kpa
—
10
12
10
12
9.17
7.72
4.2
1.4
8.1
8.5
kpa
—
10
12
11
15
8.13
7.72
2.0
1.6
—
—
—
0
0
12
9
14.97
7.61
3.7
2.1
—
—
—
0
0
12
9
14.97
7.61
1.4
1.7
—
—
—
0
0
66
371
3.39
7.57
21.0
10.1
0.0
0.0
e9/l
0.48
52
298
84
551
4.67
7.54
9.1
4.0
—
—
—
0
0
33
124
3.50
7.36
3.3
1.9
—
—
—
0
0
25
83
3.70
6.66
1.8
1.3
—
—
—
0
0
47
236
2.91
6.25
3.5
3.1
6.2
7.7
mmol/l
1.96
40
192
27
99
3.38
6.15
2.1
1.3
640.0
462.6
titre
—
10
23
87
637
4.26
5.51
7.8
3.9
23.7
12.0
mm/h
4.63
82
579
54
308
2.68
5.41
3.8
3.7
—
—
—
0
0
30
126
2.99
5.40
1.7
1.2
—
—
—
0
0
57
335
2.68
5.36
2.8
2.0
—
—
—
0
0
13
31
4.68
5.27
3.9
3.2
—
—
—
0
0
9
9
10.86
5.14
1.8
2.0
14.7
16.8
ug/l
—
9
9
17
52
3.75
5.02
1.2
1.7
—
—
—
0
0
15
42
4.04
4.99
6.7
2.9
50.7
3542.9
u/ml
0.54
15
36
9
10
9.76
4.90
2.2
2.3
4.8
4.1
e9/l
—
9
10
62
391
2.59
4.89
6.1
3.8
0.0
0.0
estimate
0.00
15
71
62
392
2.58
4.85
8.4
5.2
0.0
0.0
estimate
0.00
14
70
44
240
2.51
4.68
4.6
3.8
19.9
9.4
mg/mmol
0.55
29
145
9
11
8.87
4.67
1.0
1.1
—
—
—
0
0
12
30
4.42
4.58
1.4
1.2
—
—
—
0
0
62
399
2.51
4.56
6.2
3.8
0.0
0.0
estimate
0.00
15
67
98
870
+∞
4.55
69.3
15.9
138.1
139.7
mmol/l
5.58
98
848
35
174
2.57
4.49
1.8
1.3
3.3
2.6
g/l
0.44
18
102
9
12
8.12
4.46
2.6
1.6
—
—
—
0
0
28
125
2.74
4.43
1.6
1.7
—
—
—
0
0
92
762
4.38
4.37
7.6
4.5
2.0
2.0
mu/l
0.03
82
682
16
52
3.48
4.31
12.2
8.4
—
—
—
0
0
81
602
2.99
4.29
6.4
4.0
15.2
14.8
pmol/l
0.44
75
539
9
13
7.49
4.27
2.2
1.6
—
—
nmol/l
—
0
0
13
37
3.90
4.21
6.2
4.7
27.1
24.6
mmol/l
1.28
13
37
32
157
2.54
4.18
2.2
1.7
475.7
475.1
pmol/l
0.00
25
130
9
14
6.95
4.08
3.8
2.1
—
—
—
0
0
42
236
2.36
4.07
1.3
1.4
—
—
—
0
0
12
33
4.00
4.06
10.8
4.6
—
—
—
0
0
6
5
12.65
3.81
1.0
1.0
1.6
1.5
g/l
—
6
5
8
12
7.14
3.75
1.0
1.3
—
—
—
0
0
52
329
2.24
3.73
6.9
3.6
65.6
42.1
ng/l
0.27
43
229
36
197
2.31
3.64
3.8
3.6
—
—
—
0
0
7
9
8.27
3.62
1.0
1.4
11.7
11.1
%
—
7
9
12
36
3.66
3.61
7.4
5.5
1.7
1.5
mmol/l
0.26
12
36
6
6
10.54
3.54
1.3
2.7
—
—
—
0
0
6
6
10.54
3.54
1.2
1.5
—
—
—
0
0
98
892
+∞
3.52
65.9
16.5
78.3
78.0
umol/l
0.04
98
892
39
226
2.21
3.41
3.7
3.2
106.2
56.5
mg/l
0.57
30
143
19
79
2.74
3.39
4.2
3.5
2.2
1.1
%
0.54
11
25
22
99
2.58
3.37
1.5
1.2
—
—
—
0
0
24
114
2.46
3.29
1.8
1.4
—
—
—
0
0
13
44
3.25
3.27
3.2
2.4
—
—
—
0
0
17
69
2.77
3.16
4.3
3.8
0.4
0.4
%
—
9
19
16
63
2.84
3.14
7.1
4.9
—
—
—
0
0
7
12
6.18
3.08
4.0
2.0
—
—
—
0
0
5
5
10.43
3.01
1.0
1.0
—
—
—
0
0
5
5
10.43
3.01
1.0
1.0
—
—
—
0
0
5
5
10.43
3.01
1.6
4.2
68.2
66.0
nmol/l
—
5
5
10
30
3.60
2.99
8.3
4.2
—
—
—
0
0
89
755
2.94
2.94
56.8
15.1
36.0
40.0
%
4.53
60
554
6
9
7.01
2.91
1.0
1.3
—
—
—
0
0
8
19
4.49
2.74
1.1
1.1
—
—
—
0
0
16
68
2.62
2.73
3.7
3.8
1.0
0.5
%
—
8
14
7
15
4.94
2.65
1.7
1.5
—
—
—
0
0
32
189
2.03
2.56
1.5
1.2
1.0
1.4
u/ml
—
6
43
8
21
4.05
2.52
1.1
1.0
—
—
—
0
0
31
182
2.03
2.52
4.9
5.8
—
—
—
0
0
26
144
2.10
2.46
1.4
1.2
46.4
24.2
iu/ml
—
8
48
77
621
2.12
2.42
6.6
3.7
—
—
—
0
0
14
60
2.56
2.34
7.4
3.3
—
—
—
0
0
8
23
3.69
2.32
3.1
1.5
—
—
—
0
0
7
18
4.10
2.30
1.3
1.1
—
—
—
0
0
5
9
5.78
2.24
1.0
1.4
—
—
—
0
0
38
249
1.86
2.20
3.8
2.8
336.2
8598.6
umol/l
1.53
32
213
6
14
4.49
2.18
1.2
1.1
—
—
—
0
0
6
14
4.49
2.18
3.7
1.6
—
—
—
0
0
7
20
3.68
2.10
3.1
3.2
—
—
—
0
0
6
16
3.92
1.96
1.0
1.5
—
—
—
0
0
82
698
2.07
1.92
67.5
17.9
14.8
13.7
%
5.05
82
689
7
22
3.34
1.92
2.1
2.0
—
—
—
0
0
6
17
3.69
1.87
1.0
1.5
—
—
—
0
0
14
67
2.27
1.86
4.7
3.7
0.0
0.1
%
—
7
17
9
36
2.65
1.79
1.2
1.3
—
—
—
0
0
6
18
3.48
1.77
1.0
1.4
—
—
—
0
0
6
18
3.48
1.77
1.0
1.4
—
—
—
0
0
6
18
3.48
1.77
1.0
1.4
—
—
—
0
0
98
934
+∞
1.76
76.6
20.8
118.7
136.7
g/l
19.59
98
919
98
933
+∞
1.76
75.8
20.7
30.6
30.4
pg
0.56
98
919
98
933
+∞
1.76
76.1
20.7
3.9
4.5
e12/l
16.60
98
902
98
933
+∞
1.76
76.1
20.8
7.3
6.5
e9/l
3.56
98
903
98
933
+∞
1.76
75.8
20.7
92.5
91.1
fl
1.70
98
919
98
932
+∞
1.75
76.2
20.8
255.3
245.2
e9/l
0.67
98
905
7
26
2.82
1.61
1.6
1.6
—
—
—
0
0
19
299
0.55
1.54
3.6
2.8
—
—
—
0
0
9
37
2.57
1.52
5.2
3.5
—
—
—
0
0
18
105
1.88
1.45
1.2
1.3
—
—
—
0
0
31
214
1.66
1.43
7.8
3.4
—
—
—
0
0
5
17
3.04
1.37
1.0
1.2
—
—
—
0
0
34
243
1.61
1.36
6.6
3.9
—
—
—
0
0
14
77
1.95
1.33
9.1
4.4
—
—
—
0
0
8
41
2.03
1.11
11.0
3.0
0.2
0.1
e6/l
—
8
41
6
27
2.30
0.95
1.2
1.1
—
—
—
0
0
10
56
1.88
0.91
5.2
2.1
—
—
—
0
0
86
794
1.68
0.88
7.5
5.4
40.9
39.5
mmol/mol
0.54
77
729
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
27
209
1.40
0.71
8.4
3.8
0.0
0.0
estimate
0.00
13
67
6
35
1.76
0.59
1.5
1.1
—
—
—
0
0
17
213
0.76
0.42
2.5
2.8
0.4
0.8
ug/l
3.98
12
139
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
9
71
1.29
0.37
1.1
1.2
—
—
—
0
0
6
45
1.35
0.34
1.3
1.6
—
—
—
0
0
8
63
1.29
0.28
3.8
3.6
—
—
—
0
0
9
75
1.22
0.26
1.2
1.8
—
—
—
0
0
84
864
0.81
0.23
5.4
5.1
2.2
2.8
mmol/l
6.16
74
788
0
11
0.00
0.21
0.0
2.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
6
47
1.29
0.21
1.7
1.1
117.3
205.8
u/ml
—
6
42
10
81
1.26
0.19
1.3
1.5
—
—
—
0
0
85
827
1.21
0.19
5.6
4.6
6.2
5.9
mmol/l
1.01
78
753
83
851
0.84
0.18
5.0
4.7
4.2
4.7
mmol/l
4.00
73
782
9
80
1.14
0.15
1.8
2.0
14.0
15.5
nmol/l
—
9
73
83
847
0.87
0.13
5.0
4.6
1.3
1.5
mmol/l
1.91
73
773
33
350
0.91
0.11
3.5
4.5
1.6
1.9
ug/l
0.51
28
309
5
47
1.07
0.09
2.4
1.1
—
—
—
0
0
6
58
1.04
0.08
1.0
1.4
—
—
—
0
0
82
830
0.93
0.04
4.9
4.1
1.6
1.3
mmol/l
1.40
71
755
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
0.00
0.0
8.8
—
1331.5
—
0
8
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
12.5
—
2448.9
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
8.0
—
0
5
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
3.7
—
0
5
0
5
0.00
0.00
0.0
1.0
—
301.5
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_MG_DEF and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_MG_DEF.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: E4_MG_DEF – Magnesium deficiency

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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