No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
144 |
4. Check minimum number of eventsNone |
144 |
5. Include endpointsNone |
144 |
6. Filter based on genotype QC (FinnGen only) |
144 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Chronic thyroiditis
based on the number of shared cases.
Similar with more cases:
- Thyroiditis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1039 | 904 | 126 |
| Only index persons | 846 | 752 | 94 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.00 |
| Only index persons | 0.02 | 0.03 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 44.91 | 44.84 | 45.36 |
| Only index persons | 41.61 | 41.53 | 42.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 144 | 135 | 9 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.00 |
| Median age at first event (years) | 41.98 | 41.04 | 56.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 134
- Matched controls
- 1338
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
824.3
136.3
114
9
104
Kela drug reimbursment
Thyroid insufficiency
+∞
88.6
75
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
76.6
66
*
24503
ICD-8 Finland
Thyroiditis, Chronica
+∞
53.8
48
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
638.4
47.4
44
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
596.1
45.0
42
*
H03BB01
ATC
carbimazole; oral
596.1
45.0
42
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
39.6
36
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
33.8
31
*
E03
ICD-10 Finland
Other hypothyroidism
+∞
27.0
25
*
H062, E050
ICD-10 Finland
NA
+∞
21.4
20
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
21.4
20
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
19.2
18
*
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
18.1
17
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
+∞
18.1
17
*
T86
ICPC
Hypothyroidism/myxoedema
55.8
13.1
15
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
11.6
11
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.6
11.1
84
430
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
10.4
76
371
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
2458X
ICD-9 Finland
Thyroiditis, Other and unspecified chronic thyroiditis
+∞
8.4
8
*
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
+∞
8.4
8
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
47.8
7.8
9
*
ZXA10
NOMESCO Finland
Bilateral
3.5
7.7
40
144
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
7.4
7
*
24502
ICD-8 Finland
Thyroiditis, Subchronica
+∞
7.4
7
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.5
7.2
18
31
C07AA05
ATC
propranolol; systemic
3.2
6.9
40
155
H05.2
ICD-10 Finland
Exophthalmic conditions
42.3
6.8
8
*
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
+∞
6.3
6
*
2504
FHL
Unilateral resection or enucleation
+∞
6.3
6
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.6
6.2
59
314
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
31
21.33
54.46
4.1
1.6
4.3
4.3
pmol/l
0.01
39
26
97
581
3.05
9.13
5.9
4.9
1.2
1.2
mmol/l
0.87
83
486
87
508
2.80
8.31
3.1
2.2
83.4
78.4
nmol/l
0.80
79
452
87
522
2.68
7.65
6.0
4.4
1.2
1.2
mmol/l
0.52
77
473
80
472
2.56
7.12
3.2
3.4
35.2
35.6
g/l
0.23
75
439
68
397
2.35
5.89
2.8
3.0
2.3
2.4
mmol/l
0.65
59
348
99
680
2.46
5.89
8.4
9.0
4.0
4.0
e9/l
0.02
88
602
43
213
2.45
5.30
2.8
2.5
2.4
2.5
mmol/l
0.60
34
184
31
142
2.51
4.46
42.5
23.2
1.0
1.3
inr
—
5
17
10
22
4.81
4.37
1.2
1.2
—
—
—
0
0
10
22
4.81
4.37
1.2
1.2
—
—
—
0
0
10
23
4.60
4.16
1.0
1.3
—
—
—
0
0
138
1223
4.08
4.09
21.7
14.0
4.0
3.9
mmol/l
0.16
138
1180
138
1220
4.15
4.08
22.0
14.0
139.3
139.8
mmol/l
1.25
138
1180
18
67
2.93
3.82
1.8
1.2
451.3
83.8
iu/ml
0.62
12
22
19
73
2.85
3.82
2.0
2.3
59.8
70.0
ng/l
0.48
13
61
33
169
2.24
3.67
2.6
2.9
6.4
4.6
e6/l
0.24
22
80
70
476
1.92
3.59
2.3
1.8
90.4
95.1
pmol/l
0.28
38
218
113
921
2.05
3.17
5.4
4.0
16.5
11.7
mm/h
1.75
104
838
45
274
1.93
3.14
2.4
2.1
2.6
2.9
mg/l
0.40
38
230
89
673
1.84
3.11
4.5
4.0
6.4
6.5
mmol/l
0.27
83
617
38
221
1.98
3.01
3.2
3.5
193.4
202.2
ng/l
0.02
29
167
75
543
1.80
2.99
4.3
3.9
—
—
—
0
0
33
183
2.04
2.98
2.3
2.7
1.0
1.2
e6/l
0.22
21
93
139
1269
3.74
2.93
22.3
14.5
71.1
69.9
umol/l
0.42
139
1269
49
321
1.80
2.67
3.4
2.9
1693.6
1207.2
ng/l
0.30
40
270
85
659
1.71
2.50
6.1
5.1
10.2
10.1
umol/l
0.08
79
608
41
260
1.81
2.46
2.4
1.9
—
—
—
0
0
44
290
1.74
2.31
1.3
1.2
1.6
1.5
u/ml
0.05
13
78
14
61
2.43
2.22
2.2
2.6
5.4
5.2
kpa
0.49
14
53
134
1211
2.53
2.21
20.1
12.4
23.1
20.5
mg/l
0.44
115
924
27
155
1.91
2.20
1.7
1.6
29.4
29.8
s
0.22
27
147
57
409
1.65
2.17
3.0
2.9
—
—
—
0
0
16
76
2.24
2.12
1.1
1.6
—
—
—
0
0
7
20
3.62
2.08
1.4
1.6
—
—
—
0
0
30
182
1.82
2.06
2.2
1.9
—
—
—
0
0
22
121
1.97
2.02
1.6
1.8
28.2
28.4
u/l
0.01
17
105
22
122
1.95
1.98
3.3
4.0
27.1
7.0
ug/l
0.40
17
99
8
27
3.08
1.97
1.3
1.2
—
—
—
0
0
8
27
3.08
1.97
1.4
1.3
—
0.0
—
0
5
53
382
1.61
1.95
2.5
2.1
49.9
56.2
u/l
1.08
46
346
126
1125
1.96
1.94
18.9
11.9
78.4
80.8
ml/min/173m2
0.56
111
902
5
12
4.27
1.84
1.2
1.1
90.4
102.8
%
—
5
12
5
13
3.94
1.73
1.4
1.3
—
—
—
0
0
129
1176
1.93
1.63
4.6
4.4
5.9
5.9
mmol/l
0.01
114
1062
45
325
1.56
1.61
2.7
2.9
0.2
0.5
e6/l
1.39
34
236
5
15
3.41
1.53
1.2
1.1
142.0
116.7
%
—
5
15
34
232
1.61
1.53
1.6
1.8
419.3
26738443.8
pmol/l
0.50
21
187
5
16
3.20
1.45
1.0
1.2
—
—
—
0
0
5
16
3.20
1.45
1.4
1.1
—
—
—
0
0
33
227
1.59
1.44
1.3
1.3
32.3
29.7
iu/ml
0.05
12
80
19
113
1.78
1.40
3.0
3.5
—
—
—
0
0
10
48
2.16
1.31
2.0
2.0
—
—
—
0
0
5
18
2.84
1.29
3.2
3.6
24.6
104.4
u/ml
—
5
18
8
37
2.23
1.23
2.0
1.4
—
—
—
0
0
25
167
1.60
1.23
1.9
1.8
10.0
12.8
umol/l
1.15
25
144
19
120
1.67
1.15
2.2
1.9
—
—
—
0
0
31
222
1.51
1.13
1.3
1.3
9.9
9.9
u/ml
—
9
83
12
66
1.89
1.13
1.8
2.0
—
—
—
0
0
87
754
1.39
1.11
3.3
3.0
—
—
—
0
0
89
775
1.39
1.09
3.9
2.7
40.6
40.3
u/l
0.02
84
721
19
122
1.64
1.09
2.3
1.9
—
—
—
0
0
74
626
1.37
1.08
4.2
3.9
0.0
0.0
estimate
—
9
117
9
45
2.07
1.07
1.9
1.8
—
—
—
0
0
9
48
1.93
1.02
1.0
2.1
—
—
—
0
0
122
1130
1.52
1.00
6.0
5.4
39.7
39.3
mmol/mol
0.15
112
1048
74
634
1.34
0.97
4.2
3.9
0.0
0.0
estimate
—
8
113
11
63
1.81
0.93
1.9
1.8
—
—
—
0
0
73
627
1.33
0.93
5.9
5.3
0.0
0.0
estimate
—
8
115
53
437
1.34
0.88
3.6
3.8
16.4
22.5
ng/l
1.05
32
299
28
208
1.43
0.86
1.8
1.7
1316.8
1283.8
nmol/l
0.06
16
149
22
157
1.47
0.83
2.0
1.8
2.5
2.4
g/l
0.40
22
138
35
273
1.37
0.82
1.8
1.3
—
—
—
0
0
30
228
1.40
0.82
2.1
1.5
—
—
—
0
0
0
26
0.00
0.79
0.0
1.9
—
—
—
0
0
35
277
1.35
0.75
1.7
1.5
22.8
22.5
nmol/l
0.03
30
233
5
26
1.96
0.71
4.6
2.3
—
—
—
0
0
5
26
1.96
0.71
1.2
1.5
—
—
—
0
0
5
27
1.88
0.69
1.6
1.6
—
—
—
0
0
5
27
1.88
0.69
1.0
1.3
—
—
—
0
0
119
1122
1.35
0.64
21.0
13.2
39.8
39.5
%
0.21
87
821
16
114
1.45
0.62
1.8
1.7
—
—
—
0
0
5
30
1.69
0.62
2.8
5.4
—
4.5
—
0
5
14
99
1.46
0.56
5.4
2.5
66.0
63.5
ml/min/173m2
—
6
36
7
45
1.58
0.49
2.1
1.3
—
—
—
0
0
10
70
1.46
0.43
1.4
1.4
—
—
—
0
0
5
33
1.53
0.42
1.6
1.8
—
—
—
0
0
6
43
1.41
0.35
1.0
1.4
130.7
325.9
pmol/l
—
6
43
16
127
1.29
0.35
2.0
1.9
—
—
—
0
0
6
47
1.29
0.32
1.2
1.1
—
—
—
0
0
10
75
1.36
0.31
1.0
1.0
—
—
—
0
0
10
75
1.36
0.31
1.2
1.4
—
—
—
0
0
5
39
1.29
0.23
2.8
2.6
14.4
38.2
u/ml
—
5
39
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
13.6
—
0
10
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
13
108
1.22
0.21
2.9
3.8
1.3
1.2
mmol/l
—
6
98
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.2
1.1
—
—
—
0
0
53
498
1.10
0.18
4.6
4.0
—
—
—
0
0
31
283
1.12
0.18
2.2
1.6
1.1
1.0
mg/l
0.24
26
217
32
347
0.90
0.16
4.9
4.1
0.0
0.0
estimate
—
9
116
116
1183
0.90
0.14
4.9
4.3
4.7
4.8
mmol/l
0.40
105
1092
5
45
1.12
0.10
2.0
2.0
—
—
—
0
0
6
55
1.09
0.09
2.0
1.8
—
—
—
0
0
6
58
1.04
0.08
3.7
5.2
2.1
2.0
ug/l
—
6
47
7
68
1.03
0.08
1.7
1.5
—
—
—
0
0
116
1175
0.93
0.07
4.7
4.2
1.6
1.6
mmol/l
0.05
103
1078
112
1135
0.94
0.07
4.2
3.8
1.2
1.2
mmol/l
0.42
98
1036
120
1211
0.95
0.04
5.5
4.8
2.8
2.8
mmol/l
0.02
110
1112
14
146
0.95
0.00
10.0
7.2
—
—
—
0
0
34
335
1.02
0.00
1.9
1.6
1.3
1.3
mmol/l
0.01
29
277
5
58
0.86
0.00
8.0
3.2
57.8
42.4
%
—
5
58
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
11.9
—
0
5
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.3
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_THYROIDITCHRON and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_THYROIDITCHRON.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_THYROIDITCHRON – Chronic thyroiditis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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