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Chronic thyroiditis

DOID Endpoint Browser PheWeb

E4_THYROIDITCHRON

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E06.2
  • Hospital discharge: ICD-9 — 2453|2458
  • Hospital discharge: ICD-8 — 2450[2-4]
  • Cause of death: ICD-10 — E06.2
  • Cause of death: ICD-9 — 2453|2458
  • Cause of death: ICD-8 — 2450[2-4]

2 out of 7 registries used, show all original rules.

144

4. Check minimum number of events

None

144

5. Include endpoints

None

144

6. Filter based on genotype QC (FinnGen only)

144

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1039 904 126
Only index persons 846 752 94
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.00
Only index persons 0.02 0.03 0.00
Median age at first event (years)
Whole population 44.91 44.84 45.36
Only index persons 41.61 41.53 42.25

-FinnGen-

Key figures

All Female Male
Number of individuals 144 135 9
Unadjusted period prevalence (%) 0.04 0.05 0.00
Median age at first event (years) 41.98 41.04 56.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
134
Matched controls
1338
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
824.3
136.3
114
9
104
Kela drug reimbursment
Thyroid insufficiency
+∞
88.6
75
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
76.6
66
*
24503
ICD-8 Finland
Thyroiditis, Chronica
+∞
53.8
48
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
638.4
47.4
44
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
596.1
45.0
42
*
H03BB01
ATC
carbimazole; oral
596.1
45.0
42
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
39.6
36
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
33.8
31
*
E03
ICD-10 Finland
Other hypothyroidism
+∞
27.0
25
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
21.4
20
*
H062, E050
ICD-10 Finland
NA
+∞
21.4
20
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
+∞
19.2
18
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
+∞
18.1
17
*
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
18.1
17
*
T86
ICPC
Hypothyroidism/myxoedema
55.8
13.1
15
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
11.6
11
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.6
11.1
84
430
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.4
10.4
76
371
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
+∞
8.4
8
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
2458X
ICD-9 Finland
Thyroiditis, Other and unspecified chronic thyroiditis
+∞
8.4
8
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
47.8
7.8
9
*
ZXA10
NOMESCO Finland
Bilateral
3.5
7.7
40
144
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
7.4
7
*
24502
ICD-8 Finland
Thyroiditis, Subchronica
+∞
7.4
7
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.5
7.2
18
31
C07AA05
ATC
propranolol; systemic
3.2
6.9
40
155
H05.2
ICD-10 Finland
Exophthalmic conditions
42.3
6.8
8
*
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
+∞
6.3
6
*
2504
FHL
Unilateral resection or enucleation
+∞
6.3
6
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.6
6.2
59
314

Mortality – FinRegistry

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Association

Association between endpoint E4_THYROIDITCHRON and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITCHRON.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: E4_THYROIDITCHRON – Chronic thyroiditis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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