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Chronic thyroiditis

DOID Endpoint Browser PheWeb

E4_THYROIDITCHRON

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E06.2
  • Hospital discharge: ICD-9 — 2453|2458
  • Hospital discharge: ICD-8 — 2450[2-4]
  • Cause of death: ICD-10 — E06.2
  • Cause of death: ICD-9 — 2453|2458
  • Cause of death: ICD-8 — 2450[2-4]

2 out of 7 registries used, show all original rules.

145

4. Check minimum number of events

None

145

5. Include endpoints

None

145

6. Filter based on genotype QC (FinnGen only)

143

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1039 904 126
Only index persons 846 752 94
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.00
Only index persons 0.02 0.03 0.00
Median age at first event (years)
Whole population 44.91 44.84 45.36
Only index persons 41.61 41.53 42.25

-FinnGen-

Key figures

All Female Male
Number of individuals 143 135 8
Unadjusted period prevalence (%) 0.05 0.05 0.00
Median age at first event (years) 42.51 41.62 57.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
145
Matched controls
1450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
362.9
239.8
123
22
104
Kela drug reimbursment
Thyroid insufficiency
1686.3
91.1
79
*
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
+∞
86.3
74
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
425.3
57.6
54
*
24503
ICD-8 Finland
Thyroiditis, Chronica
+∞
53.5
48
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
52.3
47
*
H03BB01
ATC
carbimazole; oral
354.9
50.5
48
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
+∞
44.0
40
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
39.4
36
*
E03
ICD-10 Finland
Other hypothyroidism
172.0
27.7
28
*
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
24.7
23
*
H062, E050,
ICD-10 Finland
+∞
23.6
22
*
BAA60
NOMESCO Finland
Total thyroidectomy
+∞
21.4
20
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
243.6
21.2
21
*
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
243.6
21.2
21
*
T86
ICPC
Hypothyroidism/myxoedema
+∞
19.2
18
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.5
12.6
84
408
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.8
12.5
21
35
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
10.5
10
*
2458X
ICD-9 Finland
Thyroiditis, Other and unspecified chronic thyroiditis
+∞
9.5
9
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.0
8.9
94
557
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
+∞
8.4
8
*
E06.3
ICD-10 Finland
Autoimmune thyroiditis
+∞
8.4
8
*
WZC00
NOMESCO Finland
Treatment plan or consultation
2.7
7.8
68
358
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
84.2
7.5
8
*
H05.2
ICD-10 Finland
Exophthalmic conditions
84.2
7.5
8
*
24502
ICD-8 Finland
Thyroiditis, Subchronica
+∞
7.3
7
*
2504
FHL
Unilateral resection or enucleation
+∞
7.3
7
*
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
+∞
7.3
7
*
ZXA10
NOMESCO Finland
Bilateral
2.8
7.1
44
193
XCK10
NOMESCO Finland
Photography of fundus of eye
3.6
6.6
24
76
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
6.5
26
88
XCK00
NOMESCO Finland
Perimetry
4.1
6.4
19
52
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
19.0
6.3
9
5
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
+∞
6.3
6
*
H02AB07
ATC
prednisone; oral
3.1
6.2
29
108

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
46
33
19.95
52.67
4.1
1.7
4.34
4.35
pmol/l
0.03
39
28
97
588
2.96
8.77
5.9
4.9
1.21
1.23
mmol/l
0.87
83
500
87
526
2.63
7.45
6.0
4.4
1.21
1.23
mmol/l
0.65
77
483
81
479
2.57
7.18
3.2
3.4
35.11
35.59
g/l
0.27
76
446
93
597
2.56
6.78
5.6
5.1
1.82
1.94
e9/l
0.41
78
538
87
544
2.50
6.68
5.7
4.9
56.94
56.88
%
0.02
81
509
94
610
2.54
6.64
5.8
5.4
0.22
0.17
e9/l
1.19
77
542
91
583
2.51
6.59
5.5
5.0
0.59
0.54
e9/l
0.93
75
509
84
520
2.46
6.55
6.0
5.1
0.76
0.71
%
0.44
77
476
86
539
2.46
6.51
5.9
5.0
3.27
2.73
%
1.22
78
502
86
542
2.44
6.39
6.0
5.2
8.58
8.30
%
0.37
80
505
87
554
2.43
6.27
5.9
5.1
27.91
28.19
%
0.09
81
519
90
586
2.41
6.11
5.6
5.0
0.05
0.04
e9/l
1.23
75
510
100
689
2.45
5.88
8.4
9.0
3.98
3.95
e9/l
0.05
89
609
68
398
2.33
5.83
2.8
3.0
2.35
2.37
mmol/l
0.68
60
353
84
541
2.31
5.71
6.3
5.4
—
—
—
0
0
52
273
2.41
5.69
4.6
3.5
—
—
—
0
0
44
214
2.52
5.67
2.8
2.5
2.43
2.46
mmol/l
0.71
35
185
78
516
2.11
4.64
23.6
14.0
1.30
1.19
inr
0.37
25
157
139
1227
4.21
4.26
21.8
14.0
139.34
139.80
mmol/l
1.29
139
1187
18
63
3.12
4.24
1.8
1.2
451.33
67.62
iu/ml
0.65
12
21
62
388
2.04
4.17
4.1
3.2
7.40
7.39
ph
—
5
82
139
1230
4.14
4.08
21.6
14.0
3.95
3.94
mmol/l
0.23
139
1187
17
62
2.97
3.74
3.3
1.4
—
—
—
0
0
23
99
2.57
3.73
1.1
1.1
—
—
—
0
0
74
512
1.91
3.59
8.8
9.1
0.01
0.00
e9/l
0.42
56
422
70
479
1.89
3.48
2.3
1.9
90.36
94.78
pmol/l
0.26
38
220
19
77
2.69
3.46
2.0
2.2
59.77
70.05
ng/l
0.49
13
65
33
174
2.16
3.41
2.6
2.9
6.43
4.48
e6/l
0.25
22
83
22
98
2.47
3.33
5.7
5.3
122.73
120.83
g/l
0.21
22
98
46
278
1.96
3.29
2.4
2.1
2.61
2.93
mg/l
0.43
39
234
114
927
2.07
3.25
5.4
4.0
16.33
11.68
mm/h
1.70
105
844
72
509
1.82
3.14
2.5
2.0
—
—
—
0
0
140
1277
3.79
3.09
22.2
14.5
71.01
69.76
umol/l
0.43
140
1277
89
674
1.83
3.07
4.5
4.0
6.37
6.47
mmol/l
0.26
83
619
15
58
2.77
2.98
7.6
6.0
95.13
94.01
%
0.46
15
58
38
223
1.95
2.93
3.2
3.5
193.45
201.03
ng/l
0.01
29
168
24
118
2.24
2.92
1.4
1.4
—
—
—
0
0
41
251
1.88
2.78
1.5
1.4
2.14
2.36
g/l
0.30
19
146
49
318
1.82
2.76
6.3
6.8
—
—
—
0
0
6
10
6.20
2.72
1.7
1.1
—
—
—
0
0
24
123
2.14
2.64
7.1
4.4
103.13
104.19
mmol/l
0.59
24
123
7
15
4.84
2.63
1.1
1.0
—
—
—
0
0
86
665
1.72
2.58
6.1
5.1
10.33
10.03
umol/l
0.16
80
614
45
290
1.80
2.57
1.3
1.2
1.58
1.45
u/ml
0.04
14
78
61
432
1.71
2.51
3.0
3.1
—
—
—
0
0
33
195
1.90
2.47
1.7
1.8
—
—
—
0
0
16
71
2.41
2.44
1.3
1.3
—
—
—
0
0
13
52
2.65
2.43
5.9
5.9
—
—
—
0
0
52
355
1.72
2.42
3.1
3.1
42.98
36.84
e6/l
0.10
42
262
60
427
1.69
2.40
3.8
3.7
141.55
89.58
e6/l
0.18
42
286
26
144
1.98
2.34
2.3
2.0
—
—
—
0
0
135
1218
2.57
2.28
20.2
12.5
22.89
20.45
mg/l
0.40
116
930
7
18
4.03
2.28
1.1
1.2
—
—
—
0
0
9
29
3.24
2.27
1.4
2.5
26.58
26.08
mmol/l
—
9
29
52
363
1.67
2.20
2.3
2.1
—
—
—
0
0
29
172
1.86
2.14
1.7
1.6
—
—
—
0
0
20
104
2.07
2.13
1.6
1.5
—
—
—
0
0
26
149
1.91
2.12
1.4
1.3
—
—
—
0
0
10
37
2.83
2.11
2.7
2.6
—
—
—
0
0
27
158
1.87
2.07
1.7
1.6
29.40
29.89
s
0.27
27
150
26
151
1.88
2.04
1.8
1.3
—
—
—
0
0
23
129
1.93
2.00
2.0
1.4
—
—
—
0
0
10
39
2.68
1.98
1.0
1.1
—
—
—
0
0
53
385
1.59
1.88
2.5
2.1
49.91
59.85
u/l
1.31
46
350
47
332
1.62
1.86
3.4
3.6
—
—
—
0
0
15
74
2.15
1.82
1.1
2.6
—
—
—
0
0
22
126
1.88
1.80
3.3
3.9
27.07
6.83
ug/l
0.41
17
102
22
126
1.88
1.80
1.6
1.8
28.24
28.50
u/l
0.02
17
109
35
232
1.67
1.77
1.6
1.8
429.64
26738443.52
pmol/l
0.50
22
187
46
328
1.59
1.74
3.4
2.8
6.54
6.66
mmol/l
0.08
38
266
130
1184
1.95
1.66
4.6
4.4
5.86
5.86
mmol/l
0.01
115
1070
100
853
1.56
1.65
4.9
4.4
—
—
—
0
0
5
14
3.66
1.63
3.4
2.1
—
—
—
0
0
5
14
3.66
1.63
1.2
1.4
—
—
—
0
0
6
20
3.08
1.60
1.2
1.0
—
—
—
0
0
45
329
1.53
1.51
2.7
2.9
0.18
0.52
e6/l
1.40
35
237
43
312
1.54
1.49
1.7
1.4
—
—
—
0
0
44
323
1.52
1.44
2.5
2.8
—
—
—
0
0
34
236
1.58
1.43
2.9
3.0
467.79
493.75
mosm/kgh2o
0.35
29
202
44
327
1.50
1.36
4.0
3.5
9.82
7.90
mg/mmol
0.13
28
188
16
91
1.85
1.35
2.8
5.6
0.29
0.21
%
—
7
28
13
69
1.97
1.33
4.5
3.9
—
—
—
0
0
8
34
2.43
1.31
1.3
1.2
—
—
—
0
0
33
232
1.55
1.31
1.3
1.3
32.26
31.02
iu/ml
0.02
12
84
10
48
2.16
1.31
7.6
5.4
26.12
24.08
mmol/l
—
10
48
26
173
1.61
1.29
1.2
1.2
—
—
—
0
0
5
18
2.84
1.29
3.2
3.6
24.56
104.43
u/ml
—
5
18
42
314
1.48
1.25
3.3
2.9
48.94
461.83
mg/l
0.76
26
190
76
635
1.41
1.24
4.1
3.9
0.00
0.00
estimate
—
10
124
15
86
1.83
1.24
4.9
3.8
—
—
—
0
0
95
827
1.43
1.22
4.1
3.7
—
—
—
0
0
5
20
2.55
1.16
1.0
1.1
—
—
—
0
0
5
20
2.55
1.16
1.0
1.1
—
—
—
0
0
16
96
1.75
1.16
2.8
5.4
0.93
0.76
%
—
7
33
25
170
1.57
1.14
1.9
1.8
10.00
12.75
umol/l
1.13
25
151
7
30
2.40
1.14
1.1
1.1
—
—
—
0
0
33
242
1.47
1.08
2.4
2.5
8.39
5.19
e6/l
0.74
28
220
140
1344
2.21
1.06
30.2
18.5
39.45
39.49
%
0.03
131
1262
31
226
1.47
1.04
1.3
1.3
9.86
9.80
u/ml
—
9
84
7
34
2.11
1.04
3.3
3.4
—
—
—
0
0
10
53
1.95
1.04
1.0
1.2
—
—
—
0
0
18
116
1.63
1.02
1.3
1.3
—
—
—
0
0
14
84
1.74
1.02
2.8
5.6
0.50
0.67
%
—
6
26
75
640
1.36
1.02
4.2
3.9
0.00
0.00
estimate
—
9
113
7
36
1.99
0.98
3.3
2.8
—
—
—
0
0
74
633
1.35
0.98
5.9
5.3
0.00
0.00
estimate
—
9
115
0
32
0.00
0.96
0.0
1.2
—
3.94
—
0
27
7
37
1.94
0.95
2.0
2.0
19.14
20.44
s
—
7
32
140
1345
2.19
0.93
30.1
18.6
6.64
6.57
e9/l
0.18
135
1307
140
1345
2.19
0.93
30.1
18.6
4.40
4.41
e12/l
0.10
135
1306
28
206
1.45
0.90
1.8
1.7
1316.81
1293.46
nmol/l
0.04
16
147
12
72
1.73
0.88
8.9
4.7
—
—
—
0
0
12
72
1.73
0.88
5.3
4.2
—
—
—
0
0
122
1137
1.46
0.88
5.9
5.3
39.68
39.25
mmol/mol
0.17
112
1055
23
164
1.48
0.86
1.7
1.4
954.29
475.79
titre
—
7
38
36
280
1.38
0.86
1.7
1.5
22.96
22.48
nmol/l
0.05
31
236
14
89
1.63
0.85
2.9
5.6
0.00
0.00
%
—
5
24
53
441
1.32
0.82
3.6
3.8
16.38
22.51
ng/l
1.12
33
301
133
1266
1.61
0.80
18.6
11.6
—
—
—
0
0
22
160
1.44
0.76
2.0
1.8
2.52
2.39
g/l
0.39
22
141
5
24
2.12
0.75
2.8
6.2
—
—
—
0
0
5
24
2.12
0.75
1.0
1.9
—
—
—
0
0
7
40
1.79
0.72
5.9
5.3
—
—
—
0
0
13
85
1.58
0.71
4.8
2.8
10.50
10.30
g/l
0.09
13
78
19
136
1.46
0.71
1.4
1.3
—
—
—
0
0
5
27
1.88
0.69
1.6
4.7
104.80
106.11
mmol/l
—
5
27
5
27
1.88
0.69
1.6
4.6
14.60
10.74
mmol/l
—
5
27
5
28
1.81
0.67
1.4
1.8
7.30
7.73
kpa
—
5
28
5
28
1.81
0.67
2.6
1.8
—
—
—
0
0
20
147
1.42
0.66
1.9
1.6
—
—
—
0
0
11
71
1.59
0.64
3.0
2.2
—
—
—
0
0
5
30
1.69
0.62
2.6
1.8
—
—
—
0
0
6
39
1.56
0.53
2.0
1.6
2.37
9.60
ug/l
—
6
34
16
118
1.40
0.53
2.6
1.5
—
—
—
0
0
14
101
1.43
0.52
1.9
1.7
—
—
—
0
0
13
93
1.44
0.50
3.1
2.8
—
—
—
0
0
36
303
1.25
0.50
3.9
3.7
—
—
—
0
0
11
78
1.44
0.44
1.5
1.3
—
—
—
0
0
5
31
1.63
0.43
2.6
1.8
—
—
—
0
0
5
31
1.63
0.43
2.6
1.7
—
—
—
0
0
41
356
1.21
0.43
4.0
3.6
—
—
—
0
0
5
32
1.58
0.42
2.6
1.8
—
—
—
0
0
5
32
1.58
0.42
2.6
1.8
—
—
—
0
0
8
58
1.40
0.42
3.0
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
91.15
—
0
17
0
17
0.00
0.41
0.0
11.2
—
6.23
—
0
12
5
34
1.49
0.41
3.2
2.2
22.40
24.50
mmol/l
—
5
34
12
90
1.36
0.37
1.2
1.2
—
—
—
0
0
6
43
1.41
0.35
1.0
1.4
130.67
325.94
pmol/l
—
6
43
6
44
1.38
0.35
2.3
1.6
—
—
—
0
0
7
55
1.29
0.30
5.6
2.3
0.54
0.73
%
—
7
55
11
85
1.32
0.29
1.7
2.3
77.03
72.06
e9/l
—
6
62
5
40
1.26
0.22
2.8
2.6
14.40
37.87
u/ml
—
5
40
0
11
0.00
0.21
0.0
1.5
—
2.07
—
0
11
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
13
108
1.22
0.21
1.5
1.4
—
—
—
0
0
6
50
1.21
0.20
1.2
1.1
—
—
—
0
0
13
109
1.21
0.19
2.9
3.8
1.27
1.23
mmol/l
—
6
99
40
431
0.90
0.18
2.8
2.8
—
—
—
0
0
117
1192
0.90
0.13
4.8
4.2
4.73
4.82
mmol/l
0.42
106
1101
31
288
1.10
0.13
2.2
1.6
1.13
0.96
mg/l
0.26
26
222
11
95
1.17
0.12
3.6
2.6
—
—
—
0
0
10
86
1.17
0.11
1.2
1.2
—
—
—
0
0
33
348
0.93
0.09
4.8
4.1
0.00
0.00
estimate
—
10
116
6
54
1.12
0.09
1.8
3.4
0.83
0.87
%
—
6
54
6
57
1.05
0.08
3.7
5.2
2.08
1.99
ug/l
—
6
47
117
1184
0.94
0.06
4.6
4.2
1.60
1.60
mmol/l
0.05
104
1087
113
1144
0.94
0.06
4.2
3.8
1.17
1.22
mmol/l
0.48
99
1045
11
101
1.10
0.04
6.4
3.9
—
—
—
0
0
121
1220
0.95
0.04
5.4
4.8
2.81
2.81
mmol/l
0.00
111
1121
30
290
1.04
0.03
3.9
4.0
1.01
1.02
kg/l
—
5
39
10
107
0.93
0.02
4.4
3.1
—
—
—
0
0
34
339
1.00
0.00
1.9
1.6
1.26
1.27
mmol/l
0.02
29
281
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
1.97
—
0
6
0
5
0.00
-0.00
0.0
2.2
—
125.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
233.14
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
15.6
—
2590.40
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
12.80
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
11.33
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
6.0
2.7
127.14
130.25
g/l
—
7
73
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
12.0
—
1126.20
—
0
5
0
7
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDITCHRON and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITCHRON.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: E4_THYROIDITCHRON – Chronic thyroiditis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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