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Histrionic personality disorder

DOID EFO Endpoint Browser PheWeb

F5_HISPER

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F60.4
  • Hospital discharge: ICD-9 — 3015
  • Hospital discharge: ICD-8 — 3015
  • Cause of death: ICD-10 — F60.4
  • Cause of death: ICD-9 — 3015
  • Cause of death: ICD-8 — 3015

2 out of 7 registries used, show all original rules.

180

4. Check minimum number of events

None

180

5. Include endpoints

None

180

6. Filter based on genotype QC (FinnGen only)

172

Control definitions (FinnGen only)

Control exclude
F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F60
Name in latin
Personalitas histrionica

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1630 1108 491
Only index persons 1208 870 338
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.01
Only index persons 0.03 0.03 0.01
Median age at first event (years)
Whole population 37.99 39.56 33.95
Only index persons 35.62 37.32 31.25

-FinnGen-

Key figures

All Female Male
Number of individuals 172 125 47
Unadjusted period prevalence (%) 0.04 0.04 0.02
Median age at first event (years) 30.48 29.47 33.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
180
Matched controls
1800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
35.7
116.8
85
44
F60.4
ICD-10 Finland
Histrionic personality disorder
+∞
103.4
89
*
30150
ICD-8 Finland
Personality disorders, Hysterical
+∞
80.4
71
*
N05AA02
ATC
levomepromazine; systemic
35.2
75.8
51
20
T36
ICD-10 Finland
Poisoning by systemic antibiotics
36.0
72.3
48
18
N05AH04
ATC
quetiapine; oral
12.4
66.9
104
179
N05AH03
ATC
olanzapine; systemic
18.1
62.9
58
46
N05AB03
ATC
perphenazine; systemic, rectal
31.9
61.3
42
17
N03AG01
ATC
valproic acid; systemic, rectal
18.0
60.9
56
44
N05AX08
ATC
risperidone; systemic
16.0
58.4
58
52
N03AE01
ATC
clonazepam; systemic
17.3
51.4
47
36
N05CD07
ATC
temazepam; oral
10.9
48.4
65
89
N05BA01
ATC
diazepam; systemic, rectal
9.1
45.3
74
128
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
+∞
43.5
40
*
N06AB04
ATC
citalopram; systemic
7.6
41.9
94
226
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
15.3
39.7
38
31
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
14.8
38.9
38
32
F29
ICD-10 Finland
Unspecified nonorganic psychosis
15.3
35.0
33
26
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
11.2
34.7
41
46
F61.0
ICD-10 Finland
Mixed personality disorders
+∞
34.5
32
*
N06AX03
ATC
mianserin; oral
13.3
33.9
35
32
F32.9
ICD-10 Finland
Depressive episode, unspecified
7.4
33.9
63
122
F60.9
ICD-10 Finland
Personality disorder, unspecified
+∞
33.4
31
*
N06AB03
ATC
fluoxetine; oral
7.3
33.0
62
121
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
389.7
33.0
32
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
9.2
32.6
46
65
N03AX09
ATC
lamotrigine; oral
12.9
32.3
34
32
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
13.7
30.9
31
27
N06AX16
ATC
venlafaxine; oral
6.4
30.7
69
160
N05AX12
ATC
aripiprazole; systemic
14.2
30.7
30
25
P29
ICPC
Psychological sympt/compl other
9.4
30.2
41
55
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.8
29.4
48
80
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
7.2
28.9
52
96
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
39.1
28.1
35
11
N06AA09
ATC
amitriptyline; systemic
7.1
27.5
50
93
N05BA06
ATC
lorazepam; systemic, sublingual
9.9
27.5
35
43
N05BA04
ATC
oxazepam; oral
5.2
26.9
99
345
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
+∞
26.7
25
*
N05AN01
ATC
lithium; oral
30.7
25.0
33
13
3015A
ICD-9 Finland
Personality disorders, Histrionic personality disorder[HUOMIONHAKUINEN PERSOONALLISUUS]
+∞
23.4
22
*
N04AA02
ATC
biperiden; systemic
137.6
23.2
24
*
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
27.4
22.1
30
13
N05AF03
ATC
chlorprothixene; systemic
28.5
21.7
29
12
N06AX11
ATC
mirtazapine; oral
4.3
21.0
103
428
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
7.4
20.0
32
51
N06AB06
ATC
sertraline; oral
5.2
19.9
50
124
F34.1
ICD-10 Finland
Dysthymia
8.0
17.9
26
37
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
99.5
16.9
18
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
99.5
16.9
18
*
SPAT1254
SPAT
Administration of medicine
4.8
16.8
46
121
P99
ICPC
Psychological disorders other
15.8
16.1
26
19
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
+∞
15.9
15
*
N05AD01
ATC
haloperidol; systemic
20.1
15.6
23
13
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.7
15.4
32
66
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.7
15.3
26
44
F31.8
ICD-10 Finland
Other bipolar affective disorders
20.7
15.1
22
12
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
24.8
14.6
20
9
SPAT1307
SPAT
Psychosocial counselling and guidance
6.6
14.4
25
43
SPAT1240
SPAT
Therapeutic discussion
4.4
14.3
42
116
N05BA12
ATC
alprazolam; oral
4.6
14.2
39
102
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
33.1
14.2
18
6
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
58.1
14.1
16
*
N03AX16
ATC
[U] pregabalin
3.5
14.0
67
260
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
4.7
13.7
36
91
30010
ICD-8 Finland
Neuroses, Hysterical neurosis
150.9
13.6
14
*
N02AX02
ATC
tramadol; systemic, rectal
3.3
13.6
108
566
N06AA12
ATC
doxepin; systemic
5.6
13.6
28
57
N05BE01
ATC
buspirone; oral
12.4
13.5
24
22
N06AX12
ATC
bupropion; oral
6.2
13.5
25
46
N06AB10
ATC
escitalopram; oral
3.4
13.1
65
257
N05AD03
ATC
melperone; systemic
54.2
13.1
15
*
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
34.9
12.8
16
5
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
75.3
12.8
14
*
F60.0
ICD-10 Finland
Paranoid personality disorder
+∞
12.6
12
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.9
12.6
45
143
N07BB01
ATC
disulfiram; oral
9.8
12.5
25
29
N05AC02
ATC
thioridazine; oral
17.5
12.5
19
12
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
29.0
12.3
16
6
N05CF01
ATC
zopiclone; oral
3.1
12.2
83
392
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
50.2
12.1
14
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
6.1
12.0
22
40
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
18.0
11.9
18
11
N05AF05
ATC
zuclopenthixol; systemic
69.6
11.8
13
*
30180
ICD-8 Finland
Personality disorders, Immatura
69.6
11.8
13
*
S06.0
ICD-10 Finland
Concussion
4.2
11.7
36
102
F60.8
ICD-10 Finland
Other specific personality disorders
127.8
11.6
12
*
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
37.7
11.4
14
*
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
14.0
11.4
19
15
D01AC02
ATC
miconazole; topical
4.7
11.1
28
68
E9509
ICD-8 Finland
Suicide and self-inflicted poisoning by solid or liquid substances, Other and unspecified solid and liquid substances
46.4
11.1
13
*
F60.5
ICD-10 Finland
Anankastic personality disorder
46.4
11.1
13
*
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
23.2
10.9
15
7
N03AX11
ATC
topiramate; oral
12.3
10.8
19
17
P80
ICPC
Personality disorder
116.5
10.5
11
*
30188
ICD-8 Finland
Personality disorders, Alia definita
+∞
10.5
10
*
30041
ICD-8 Finland
Neuroses, Depressiva
20.3
10.5
15
8
N03AF02
ATC
oxcarbazepine; oral
9.4
10.4
21
25
R60.9
ICD-10 Finland
Oedema, unspecified
5.8
10.4
20
38
9694A
ICD-9 Finland
Poisoning by psychotropic agents, Benzodiazepine-based tranquillisers
42.6
10.1
12
*
N06AB08
ATC
fluvoxamine; oral
13.3
10.1
17
14
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
11.6
10.0
18
17
30000
ICD-8 Finland
Neuroses, Anxiety neurosis
21.5
10.0
14
7
K08.3
ICD-10 Finland
Retained dental root
4.8
9.9
24
56
R06.0
ICD-10 Finland
Dyspnoea
2.8
9.9
69
324
29999
ICD-8 Finland
Unspecified psychosis
58.2
9.8
11
*
P19
ICPC
Drug abuse
58.2
9.8
11
*
A06AD11
ATC
lactulose; oral
3.5
9.7
38
127
L28
ICPC
Limited function/disability (L)
3.2
9.6
46
174
N06AA04
ATC
clomipramine; systemic
13.4
9.6
16
13
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
13.4
9.6
16
13
M54.5
ICD-10 Finland
Low back pain
2.7
9.5
84
444
K59.09
ICD-10 Finland
Constipation, unspecified
4.5
9.3
24
59
P72
ICPC
Schizophrenia
12.4
9.3
16
14
F20.9
ICD-10 Finland
Schizophrenia, unspecified
12.4
9.3
16
14
M54.9
ICD-10 Finland
Dorsalgia, unspecified
3.4
9.2
37
126
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.7
9.1
71
351
SPAT1234
SPAT
Support of social functional capacity
5.3
9.1
19
39
U01
ICPC
Dysuria/painful urination
4.3
9.0
25
65
F41.1
ICD-10 Finland
Generalized anxiety disorder
4.8
8.9
21
48
N06CA01
ATC
amitriptyline and psycholeptics; systemic
3.6
8.9
32
101
F39
ICD-10 Finland
Unspecified mood [affective] disorder
15.0
8.8
14
10
F10.20
ICD-10 Finland
Alcohol dependence currently independent
17.4
8.7
13
8
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
5.1
8.6
19
41
A28
ICPC
Limited function/disability NOS
3.2
8.5
40
149
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
8.5
49
206
30199
ICD-8 Finland
Personality disorders, Unspecified
+∞
8.4
8
*
3015B
ICD-9 Finland
Personality disorders, Histrionic personality disorder[ITSEAIHEUTETTU HÄIRIÖ,RUUMIILLISIN OIREIN]
+∞
8.4
8
*
29580
ICD-8 Finland
Schizophrenia, Other
+∞
8.4
8
*
9690A
ICD-9 Finland
Poisoning by psychotropic agents, Antidepressants
+∞
8.4
8
*
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
15.4
8.3
13
9
N05AF01
ATC
flupentixol; systemic
15.4
8.3
13
9
P76
ICPC
Depressive disorder
4.2
8.3
23
60
N05AB01
ATC
dixyrazine; systemic
18.2
8.2
12
7
AA1AD
NOMESCO Finland
CT of head and brain
2.6
8.2
61
292
F22.0
ICD-10 Finland
Delusional disorder
35.1
8.2
10
*
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
35.1
8.2
10
*
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
35.1
8.2
10
*
Z76.0
ICD-10 Finland
Issue of repeat prescription
2.7
8.2
57
264
SPAT1229
SPAT
Assessment of need for aid
4.3
8.2
22
56
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
23.3
8.1
11
5
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
8.0
39
148
N06AG02
ATC
moclobemide; oral
6.9
8.0
19
30
N05CD02
ATC
nitrazepam; oral
11.6
7.9
14
13
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
7.9
54
247
R02
ICPC
Shortness of breath/dyspnoea
3.2
7.9
36
132
N03AX12
ATC
[U] gabapentin; oral
2.8
7.7
47
202
F43.20
ICD-10 Finland
Adaptation disorder with short-term depression
12.6
7.7
13
11
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
19.4
7.7
11
6
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
19.4
7.7
11
6
SPAT1260
SPAT
Consultation of another employee
2.9
7.7
44
183
N06AB05
ATC
paroxetine; oral
4.3
7.7
21
54
E66.8
ICD-10 Finland
Other obesity
4.8
7.6
18
41
W19
ICD-10 Finland
Unspecified fall
3.7
7.6
26
79
R42
ICD-10 Finland
Dizziness and giddiness
2.7
7.5
51
232
F13.22
ICD-10 Finland
Addiction relationship caused by sedatives and hypnotics currently independent but uses substitute intermittent medication
83.4
7.5
8
*
Z72.8
ICD-10 Finland
Other problems related to lifestyle
83.4
7.5
8
*
188
Kela drug reimbursment
Psychosis requiring demanding treatment
83.4
7.5
8
*
F13.1
ICD-10 Finland
Mental and behavioural disorders due to use of sedatives or hypnotics, harmful use
83.4
7.5
8
*
N06AX22
ATC
agomelatine; oral
11.6
7.4
13
12
U05
ICPC
Urination problems other
6.5
7.3
18
30
C07AA05
ATC
propranolol; systemic
2.6
7.3
54
256
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.7
7.3
25
76
N05AA01
ATC
chlorpromazine; systemic, rectal
21.0
7.2
10
5
N06AX26
ATC
vortioxetine; oral
4.0
7.1
21
57
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.8
7.1
42
177
SPAT1301
SPAT
No procedures
2.4
7.1
68
363
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.9
7.1
37
146
C03CA01
ATC
furosemide; systemic
2.5
7.0
61
311
P01
ICPC
Feeling anxious/nervous/tense
3.0
7.0
35
135
F51.0
ICD-10 Finland
Nonorganic insomnia
2.8
7.0
39
160
U04
ICPC
Incontinence urine
4.6
6.9
17
40
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
6.9
66
351
E000001, ,
ATC
2.6
6.9
49
227
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.9
6.9
36
142
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
4.0
6.9
20
54
IGY02, ,
SPAT
41.7
6.8
8
*
P18
ICPC
Medication abuse
41.7
6.8
8
*
M01AG02
ATC
tolfenamic acid; oral, rectal
2.8
6.8
39
162
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.5
6.7
25
80
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
23.5
6.7
9
*
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
23.5
6.7
9
*
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
6.6
6.6
16
26
A46
ICD-10 Finland
Erysipelas
2.9
6.6
34
133
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
6.5
80
471
J01EA01
ATC
trimethoprim; systemic
2.4
6.5
62
328
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
15.0
6.5
10
7
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.4
6.5
16
27
F19.25
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances continuously used
72.3
6.5
7
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
8.7
6.5
13
16
N03AF01
ATC
carbamazepine; oral, rectal
4.1
6.4
18
47
R07.4
ICD-10 Finland
Chest pain, unspecified
2.3
6.4
64
345
Z29
ICPC
Social problem NOS
9.8
6.4
12
13
Z71.8
ICD-10 Finland
Other specified counselling
2.3
6.3
67
370
R03BA05
ATC
fluticasone; inhalant
2.6
6.3
45
208
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.4
6.3
24
78
F60.2
ICD-10 Finland
Dissocial personality disorder
+∞
6.3
6
*
F60.7
ICD-10 Finland
Dependent personality disorder
+∞
6.3
6
*
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
+∞
6.3
6
*
F61
ICD-10 Finland
Mixed and other personality disorders
+∞
6.3
6
*
34599
ICD-8 Finland
Epilepsy, Other and unspecified
27.7
6.3
8
*
R29
ICPC
Respiratory symptom/complaint other
3.5
6.2
22
68
ZY010
NOMESCO Finland
Hospital outpatient
4.4
6.2
16
39
D07AB02
ATC
hydrocortisone butyrate; topical
2.3
6.2
65
357
R05
ICPC
Cough
2.3
6.2
60
319
OAB43, ,
SPAT
0.2
6.2
9
330
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.4
6.1
15
25
SPAT1262
SPAT
Handing over of treatment supplies
2.7
6.1
38
164
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.8
6.1
19
54

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
30
29
12.21
27.89
3.8
1.4
—
—
—
0
0
27
35
8.90
20.12
3.1
1.3
—
—
—
0
0
30
45
7.80
19.80
3.0
1.4
—
—
—
0
0
30
45
7.80
19.80
3.0
1.4
—
—
—
0
0
30
46
7.63
19.41
3.0
1.4
—
—
—
0
0
30
46
7.63
19.41
3.0
1.4
—
—
—
0
0
28
47
6.87
16.61
3.0
1.4
—
—
—
0
0
23
18
14.46
13.86
2.9
1.5
—
—
—
0
0
132
853
3.05
10.27
5.5
4.1
6.45
6.58
mmol/l
0.30
125
788
87
455
2.77
10.17
3.2
2.3
58.00
57.98
u/l
0.00
81
428
12
5
25.54
9.03
16.7
5.2
0.61
0.60
mmol/l
—
12
5
67
331
2.63
8.48
1.4
1.5
18.11
22.49
nmol/l
1.40
57
273
79
425
2.53
8.35
2.7
2.0
138.12
147.31
u/l
0.18
73
407
111
699
2.53
8.34
4.9
6.3
1.21
1.22
mmol/l
0.44
96
610
94
563
2.40
7.69
2.3
1.9
93.64
99.26
pmol/l
0.44
49
262
27
85
3.56
7.47
3.2
4.7
—
—
—
0
0
64
333
2.43
7.06
5.4
3.6
1.01
1.02
kg/l
—
6
39
89
537
2.30
6.96
5.7
3.3
54.11
35.67
ng/l
0.28
65
353
116
783
2.35
6.94
5.0
6.2
10.14
10.22
umol/l
0.03
106
749
149
1131
2.84
6.83
7.9
7.5
85.97
76.33
u/l
1.00
142
1063
100
642
2.25
6.64
5.2
5.2
1.21
1.22
mmol/l
0.54
92
592
55
274
2.45
6.62
1.9
1.7
434.00
461.53
pmol/l
0.33
44
236
75
429
2.28
6.58
3.5
3.0
6.38
7.59
mmol/l
1.65
63
360
67
366
2.32
6.54
5.0
4.1
—
—
—
0
0
36
146
2.83
6.54
3.3
6.6
5.30
5.12
kpa
0.50
36
141
61
322
2.35
6.43
2.0
1.7
0.75
1.04
mg/l
0.92
45
253
62
332
2.32
6.31
1.7
2.0
2.93
3.36
mg/l
0.60
49
286
35
148
2.69
5.85
3.2
6.6
1.89
1.47
mmol/l
0.32
27
117
95
619
2.13
5.84
4.4
4.2
35.07
36.04
g/l
0.84
86
586
17
46
3.98
5.80
3.8
3.9
3.91
3.81
mmol/l
0.30
17
46
97
651
2.06
5.36
17.1
11.1
1.14
1.19
inr
0.25
35
182
47
239
2.31
5.29
2.3
1.6
1097.37
1229.73
nmol/l
0.50
35
176
30
125
2.68
5.14
3.2
3.0
6.15
5.75
kpa
1.33
30
125
37
173
2.43
5.01
4.5
5.6
105.32
104.18
mmol/l
0.63
37
173
22
79
3.03
4.92
3.1
2.4
25.65
24.97
mmol/l
0.38
22
79
25
97
2.83
4.88
3.4
6.6
—
—
—
0
0
101
710
1.96
4.68
5.4
6.3
—
—
—
0
0
74
468
1.99
4.67
6.1
2.8
—
—
—
0
0
27
112
2.66
4.65
3.4
2.4
7.24
4.83
ug/l
0.20
21
99
43
227
2.17
4.37
2.1
3.1
0.84
0.80
mmol/l
0.91
36
214
29
130
2.47
4.27
3.3
3.0
—
—
—
0
0
17
57
3.19
4.25
6.8
4.1
—
—
—
0
0
28
124
2.49
4.23
3.6
3.1
—
—
—
0
0
143
1166
2.10
3.98
6.2
4.0
14.57
14.71
pmol/l
0.26
134
1056
131
1040
1.95
3.88
7.0
4.1
—
—
—
0
0
12
29
4.36
3.78
1.1
1.1
—
—
—
0
0
8
12
6.92
3.71
13.0
21.8
1355.13
1291.67
nmol/l
—
8
12
24
106
2.46
3.64
3.3
2.5
4.21
4.37
kpa
0.18
24
106
64
414
1.85
3.60
5.8
3.5
—
—
—
0
0
112
858
1.81
3.58
10.2
10.0
4.36
4.00
e9/l
1.00
97
762
20
84
2.55
3.37
4.0
6.8
0.75
0.71
%
0.15
20
84
20
84
2.55
3.37
4.0
6.8
2.60
1.35
%
2.16
20
84
94
693
1.75
3.34
5.4
6.0
8.05
8.29
%
0.35
85
649
87
628
1.75
3.33
4.7
3.2
—
5.71
—
0
52
95
707
1.73
3.23
5.3
5.8
28.60
28.48
%
0.04
86
665
93
689
1.72
3.21
5.1
5.7
2.75
2.79
%
0.06
84
644
137
1134
1.87
3.20
4.0
4.1
12.34
10.93
mm/h
0.70
122
1044
90
662
1.72
3.18
5.1
5.7
0.67
0.69
%
0.09
80
614
100
760
1.71
3.11
5.6
5.9
0.18
0.18
e9/l
0.17
83
674
47
290
1.84
3.01
4.1
2.8
493.08
556.47
mosm/kgh2o
0.92
39
245
159
1396
2.19
2.96
7.6
4.7
1.66
1.86
mu/l
1.74
147
1279
93
700
1.68
2.95
4.8
5.5
56.71
56.96
%
0.07
84
658
64
443
1.69
2.74
2.7
3.8
7.41
7.40
ph
0.15
13
78
70
499
1.66
2.67
2.4
3.2
2.36
2.36
mmol/l
0.09
59
442
8
20
4.13
2.60
2.0
1.4
—
—
—
0
0
95
735
1.62
2.59
5.5
5.7
0.58
0.56
e9/l
0.57
83
642
95
738
1.61
2.53
5.6
5.7
0.04
0.04
e9/l
0.28
83
642
157
1392
2.00
2.53
7.3
5.4
39.40
39.39
mmol/mol
0.01
143
1306
58
399
1.67
2.51
6.7
3.6
0.00
0.00
estimate
-0.00
20
129
41
256
1.78
2.51
6.0
3.1
12.36
138.27
ng/l
2.01
28
192
73
535
1.61
2.46
4.8
3.4
99.26
56.77
e6/l
0.63
55
357
9
27
3.45
2.43
2.1
2.6
26.61
25.11
mmol/l
—
9
27
6
12
5.13
2.42
12.5
14.3
852.17
771.50
nmol/l
—
6
12
51
344
1.67
2.37
1.5
1.2
0.45
1.02
u/ml
1.23
15
91
96
756
1.58
2.36
5.7
5.6
2.04
1.98
e9/l
0.15
86
677
30
174
1.87
2.31
2.0
1.5
—
—
—
0
0
20
102
2.08
2.20
2.8
3.1
62.34
70.50
e9/l
0.54
13
76
6
163
0.35
2.14
1.2
1.5
—
—
—
0
0
23
126
1.95
2.10
1.1
1.2
—
—
—
0
0
35
220
1.73
2.08
1.9
2.1
12.09
13.27
umol/l
0.42
29
209
5
10
5.11
2.08
1.6
1.9
77.40
72.60
umol/l
—
5
10
5
10
5.11
2.08
3.0
1.8
9.40
7.39
mmol/l
—
5
10
24
134
1.91
2.08
4.0
4.3
—
—
—
0
0
21
112
1.99
2.06
1.3
1.4
—
—
—
0
0
164
1502
2.03
2.00
21.8
12.9
21.71
21.80
mg/l
0.01
143
1165
6
159
0.36
2.00
1.0
1.3
—
—
—
0
0
31
191
1.75
1.98
1.6
1.4
—
—
—
0
0
57
412
1.56
1.97
3.8
2.9
0.29
0.42
e6/l
0.45
48
298
6
16
3.84
1.95
2.3
3.5
—
—
—
0
0
50
352
1.58
1.93
6.2
3.4
—
—
—
0
0
58
423
1.55
1.92
4.1
3.8
14.99
9.94
mg/mmol
0.24
34
268
12
53
2.35
1.85
1.1
1.4
—
1.86
—
0
5
82
648
1.49
1.85
8.5
9.3
0.00
0.00
e9/l
0.30
68
530
21
117
1.90
1.84
1.9
3.2
56.06
70.61
ng/l
0.86
16
102
27
164
1.76
1.81
1.5
1.6
—
—
—
0
0
41
571
0.63
1.78
2.7
2.7
—
—
—
0
0
55
406
1.51
1.70
3.6
2.8
—
—
—
0
0
30
193
1.67
1.65
2.0
2.1
18.60
22.41
%
0.96
24
175
5
14
3.64
1.62
1.8
2.2
92.78
89.15
%
—
5
14
5
14
3.64
1.62
2.0
1.7
—
—
—
0
0
10
43
2.40
1.61
1.6
1.6
—
—
—
0
0
41
288
1.55
1.58
2.2
1.8
—
—
—
0
0
7
27
2.66
1.53
1.9
2.6
8.51
7.91
kpa
—
7
27
6
21
2.92
1.52
1.0
1.0
—
—
—
0
0
9
37
2.51
1.50
1.2
1.2
—
—
—
0
0
30
198
1.62
1.50
1.9
2.1
2.41
2.38
g/l
0.11
23
184
62
480
1.44
1.49
1.9
2.1
—
—
—
0
0
10
45
2.29
1.49
1.1
1.2
—
—
—
0
0
11
52
2.19
1.47
2.5
2.0
—
—
—
0
0
14
74
1.97
1.43
4.2
2.1
1.65
1.36
%
0.32
14
74
53
402
1.45
1.41
3.5
3.2
1421.20
59.62
mg/l
0.49
34
259
51
384
1.46
1.41
2.3
2.6
339.59
7478.85
umol/l
2.28
46
337
32
219
1.56
1.38
2.1
1.8
—
—
—
0
0
58
450
1.43
1.37
4.5
2.9
168.69
62.44
e6/l
0.57
50
336
11
54
2.10
1.36
3.1
3.1
—
—
—
0
0
0
39
0.00
1.35
0.0
3.6
—
39.35
—
0
39
28
188
1.58
1.31
2.7
2.3
75.32
144.06
ug/g
1.13
19
147
12
62
2.00
1.31
3.3
6.3
—
—
—
0
0
26
172
1.60
1.30
1.7
2.5
4.37
6.17
umol/l
1.01
19
150
15
85
1.83
1.27
1.2
1.2
—
—
—
0
0
43
320
1.45
1.26
1.5
1.4
1.99
2.28
g/l
0.92
28
192
89
752
1.36
1.25
6.6
3.5
0.00
0.00
estimate
-0.00
22
139
19
117
1.70
1.24
2.5
4.7
0.00
0.17
%
—
6
36
13
71
1.90
1.23
4.5
2.2
0.79
0.67
%
1.06
13
71
81
678
1.35
1.19
3.1
2.5
93.08
93.79
ug/l
0.01
70
632
48
369
1.41
1.18
7.4
7.3
—
—
—
0
0
20
127
1.65
1.17
2.4
4.5
0.57
1.00
%
—
7
46
18
111
1.69
1.17
1.3
2.5
67.18
66.96
g/l
0.04
13
100
8
39
2.10
1.17
2.4
2.3
1.44
1.41
mmol/l
—
8
39
0
35
0.00
1.16
0.0
1.9
—
—
—
0
0
22
144
1.60
1.15
2.0
3.0
1.85
1.80
%
0.05
17
132
89
761
1.34
1.12
7.2
3.5
0.00
0.00
estimate
-0.00
19
127
16
97
1.71
1.11
1.4
2.3
4.54
4.47
e9/l
0.03
11
79
5
21
2.42
1.10
1.8
2.7
—
—
—
0
0
168
1601
1.74
1.04
24.0
14.6
74.29
73.05
umol/l
0.18
168
1601
156
1467
1.48
0.98
5.6
4.3
6.03
5.86
mmol/l
0.71
140
1347
9
51
1.80
0.96
2.6
3.8
23.67
24.80
mmol/l
—
9
51
6
27
2.26
0.94
5.5
3.8
4.37
4.54
e9/l
—
6
27
6
27
2.26
0.94
5.3
4.6
57.00
60.81
%
—
6
27
6
28
2.18
0.92
3.2
2.3
5.92
5.31
kpa
—
6
28
6
28
2.18
0.92
3.2
2.3
8.65
8.59
kpa
—
6
28
87
758
1.29
0.90
8.7
4.9
0.00
0.00
estimate
-0.00
20
134
113
1023
1.28
0.84
4.7
3.6
—
—
—
0
0
17
114
1.54
0.83
2.6
4.6
2.29
0.53
%
—
7
36
11
174
0.61
0.81
1.1
1.2
—
—
—
0
0
12
74
1.67
0.80
3.2
4.7
27.48
25.58
mmol/l
0.36
12
74
6
33
1.85
0.80
1.2
1.3
—
—
—
0
0
7
39
1.83
0.73
2.0
2.3
6.74
6.85
mmol/l
—
7
39
9
57
1.61
0.72
1.4
1.3
—
—
—
0
0
7
40
1.78
0.72
1.1
1.2
—
—
—
0
0
124
1325
0.79
0.69
30.3
16.2
331.49
332.06
g/l
0.34
124
1319
9
140
0.62
0.63
1.2
1.5
—
—
—
0
0
13
183
0.69
0.59
1.2
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.6
—
—
—
0
0
6
35
1.74
0.58
13.7
2.0
—
—
—
0
0
16
116
1.42
0.56
5.8
3.9
—
—
—
0
0
12
170
0.68
0.56
1.8
1.8
—
—
—
0
0
9
59
1.55
0.56
1.8
1.8
8.06
6.72
ug/l
—
9
52
9
61
1.50
0.54
5.8
1.6
—
—
—
0
0
9
62
1.48
0.54
1.2
1.2
—
—
—
0
0
28
225
1.29
0.53
4.1
2.8
3.17
3.40
e6/l
0.07
20
117
156
1502
1.29
0.51
4.6
4.2
4.63
4.74
mmol/l
0.64
139
1402
166
1612
1.38
0.50
13.3
10.1
24.82
25.49
u/l
0.25
156
1561
13
95
1.40
0.45
1.5
2.3
—
—
—
0
0
24
196
1.26
0.42
1.6
1.3
—
—
—
0
0
11
79
1.42
0.42
6.5
3.4
—
—
—
0
0
158
1532
1.26
0.41
5.2
4.7
2.78
2.79
mmol/l
0.07
140
1418
57
628
0.86
0.36
1.9
2.0
—
—
—
0
0
29
249
1.20
0.33
1.9
1.6
—
—
—
0
0
149
1444
1.18
0.33
4.0
3.8
1.47
1.26
mmol/l
2.54
128
1338
7
53
1.33
0.31
13.1
10.8
—
—
—
0
0
153
1495
1.16
0.24
4.5
4.2
1.43
1.52
mmol/l
1.81
135
1387
5
42
1.20
0.21
1.4
3.5
38.64
27.26
mg/l
—
5
35
5
42
1.20
0.21
1.4
3.5
46.90
39.89
mg/l
—
5
35
5
42
1.20
0.21
1.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
164.89
—
0
11
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
11.59
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
31
279
1.13
0.21
1.1
1.3
1.58
10.84
u/ml
2.86
13
115
0
13
0.00
0.21
0.0
2.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
3.6
—
—
—
0
0
12
99
1.23
0.20
1.3
1.2
—
—
—
0
0
5
68
0.73
0.17
2.0
2.2
—
—
—
0
0
10
117
0.85
0.13
1.6
1.5
—
—
—
0
0
31
291
1.08
0.10
1.2
1.3
12.07
33.04
iu/ml
—
10
100
5
44
1.14
0.10
6.4
4.4
—
—
—
0
0
41
429
0.94
0.09
1.6
1.4
—
—
—
0
0
161
1595
1.09
0.08
23.5
11.7
—
—
—
0
0
40
417
0.95
0.07
6.7
3.2
—
—
—
0
0
42
405
1.05
0.06
1.6
1.6
1.34
1.34
mmol/l
0.00
33
352
16
159
1.01
0.00
2.0
1.7
—
—
—
0
0
13
135
0.96
0.00
1.2
1.4
—
—
—
0
0
10
95
1.06
0.00
9.7
2.8
—
—
—
0
0
168
1685
0.96
0.00
33.6
18.9
38.53
40.31
%
1.93
159
1593
0
5
0.00
0.00
0.0
1.8
—
202.94
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
99.40
—
0
9
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
9.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
5.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
32.8
—
77.83
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
68.14
—
0
7
0
9
0.00
-0.00
0.0
1.8
—
0.90
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
1.58
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint F5_HISPER and mortality.

Females

Parameter HR [95% CI] p-value
F5_HISPER 3.111 [2.32, 4.18] < 0.001
Birth year 0.994 [0.99, 1.0] 0.171

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 395 females with F5_HISPER died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have F5_HISPER.

N-year risk Females Males
1 0.352% No data
5 1.577% No data
10 4.391% No data
15 7.889% No data
20 13.936% No data

Relationships between endpoints

↥

Index endpoint: F5_HISPER – Histrionic personality disorder

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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