viral meningitis: Viral infections of the leptomeninges and subarachnoid space. TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and RETROVIRIDAE INFECTIONS may cause this form of meningitis. Clinical manifestations include fever, headache, neck pain, vomiting, PHOTOPHOBIA, and signs of meningeal irritation. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
159 |
4. Check minimum number of eventsNone |
159 |
5. Include endpointsNone |
159 |
6. Filter based on genotype QC (FinnGen only) |
159 |
Control definitions (FinnGen only)
- Control exclude
- G6_NEUINFL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Meningitis, viral
based on the number of shared cases.
Similar with more cases:
- Meningitis
- Inflammatory diseases of the central nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1037 | 609 | 424 |
| Only index persons | 980 | 583 | 397 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.25 | 39.74 | 31.18 |
| Only index persons | 36.97 | 39.99 | 32.53 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 159 | 112 | 47 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.02 |
| Median age at first event (years) | 43.09 | 39.73 | 51.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 144
- Matched controls
- 1440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G02.0*B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
87.7
75
*
A87.9
ICD-10 Finland
Viral meningitis, unspecified
568.5
70.0
64
*
J05AB11
ATC
valaciclovir; oral
11.7
31.3
65
94
R51.80
ICD-10 Finland
Headache
9.6
28.7
68
122
TAB00
NOMESCO Finland
Lumbar puncture
27.6
28.5
39
19
G02.0*B02.1
ICD-10 Finland
Zoster meningitis
+∞
26.9
25
*
G02.0
ICD-10 Finland
Meningitis in viral diseases classified elsewhere
+∞
25.8
24
*
G02.0*B01.0
ICD-10 Finland
Varicella meningitis
+∞
21.4
20
*
G02.0*A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
19.2
18
*
G03.9
ICD-10 Finland
Meningitis, unspecified
+∞
19.2
18
*
J05AB01
ATC
aciclovir; systemic
6.1
18.9
61
154
A86
ICD-10 Finland
Unspecified viral encephalitis
141.8
12.6
13
*
AA1AD
NOMESCO Finland
CT of head and brain
4.5
12.3
50
152
B00.3
ICD-10 Finland
Herpesviral meningitis
+∞
11.6
11
*
A87.8
ICD-10 Finland
Other viral meningitis
+∞
11.6
11
*
5AB01
NOMESCO Finland
NA
+∞
10.5
10
*
N01
ICPC
Headache
4.6
9.4
34
90
B02.9
ICD-10 Finland
Zoster without complication
8.4
7.6
16
21
N02BE01
ATC
paracetamol; systemic, rectal
3.9
7.6
129
990
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
16.9
7.4
11
7
N71
ICPC
Meningitis/encephalitis
+∞
7.3
7
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
7.3
7
*
B02.1
ICD-10 Finland
Zoster meningitis
+∞
7.3
7
*
ZX120
NOMESCO Finland
Intravenous
4.5
6.7
23
58
XF400
NOMESCO Finland
ECG with 12 standard connections
3.6
6.6
30
97
H02AB06
ATC
prednisolone; systemic
2.5
6.5
75
438
B00.19
ICD-10 Finland
Other vesicular dermatitis caused by the herper simplex virus
72.9
6.5
7
*
B00.4
ICD-10 Finland
Herpesviral encephalitis
+∞
6.3
6
*
A87.0
ICD-10 Finland
Enteroviral meningitis
+∞
6.3
6
*
G05.1*B00.4
ICD-10 Finland
Herpesviral meningoencephalitis
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
6.2
63
339
N03AX16
ATC
pregabalin; oral
2.8
6.0
43
191
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
35
20.38
58.00
1.5
1.3
154.5
3.0
e6/l
4.19
40
25
50
35
20.38
58.00
1.5
1.4
21.0
267.7
e6/l
0.79
41
28
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
42
5
112.98
40.08
1.4
1.2
—
—
—
0
0
43
8
72.88
38.71
1.5
1.3
—
—
—
0
0
25
14
21.00
31.43
1.4
1.1
—
—
—
0
0
22
14
18.08
25.89
1.4
1.1
—
—
—
0
0
19
14
15.28
20.58
1.3
1.0
—
—
—
0
0
20
17
13.31
19.96
1.4
1.1
—
—
—
0
0
16
11
16.06
17.87
1.6
1.7
—
—
—
0
0
21
7
34.23
16.58
1.5
1.1
2.4
1.7
mmol/l
—
21
7
19
5
42.76
15.78
1.3
1.0
—
—
—
0
0
20
7
32.36
15.62
1.3
1.0
—
—
—
0
0
14
13
11.71
13.04
1.3
1.3
885.6
858.3
e6/l
—
5
6
21
38
6.22
11.51
1.3
1.1
—
—
—
0
0
13
6
23.41
9.52
1.6
2.0
—
—
—
0
0
13
7
20.04
9.10
1.3
1.0
93.1
—
%
—
7
0
11
13
9.02
8.56
1.1
1.3
—
—
—
0
0
12
7
18.38
8.21
3.3
1.3
319.8
842.4
u/ml
—
12
7
12
8
16.08
7.85
1.1
1.3
—
—
—
0
0
11
8
14.65
7.00
1.8
2.0
—
—
—
0
0
16
36
4.83
6.88
1.4
1.4
—
—
—
0
0
35
140
2.92
6.59
2.2
1.9
28.8
29.7
s
0.49
35
135
108
740
2.43
6.38
9.7
9.2
4.1
4.1
e9/l
0.04
101
653
42
190
2.65
6.25
4.2
2.8
28.2
76.9
ng/l
0.74
26
116
9
6
15.78
5.97
1.1
1.0
—
—
—
0
0
23
79
3.23
5.57
2.0
1.6
—
—
—
0
0
29
118
2.78
5.24
1.6
1.7
—
—
—
0
0
5
0
+∞
5.23
1.4
0.0
—
—
—
0
0
12
27
4.73
5.13
1.2
1.4
—
—
—
0
0
12
27
4.73
5.13
1.2
1.4
—
—
—
0
0
51
274
2.27
5.13
1.5
1.7
0.6
0.7
mg/l
0.36
39
204
64
394
2.04
4.45
2.9
3.2
22.4
20.5
ng/l
0.13
30
226
35
170
2.36
4.39
2.8
2.5
3.9
3.5
e6/l
0.06
14
88
27
116
2.60
4.38
1.6
1.6
—
—
—
0
0
15
46
3.50
4.31
1.9
1.5
—
—
—
0
0
17
57
3.22
4.27
1.4
1.6
—
—
—
0
0
11
28
4.15
4.05
1.5
1.5
—
—
—
0
0
35
179
2.22
3.87
1.7
1.8
—
—
—
0
0
8
13
6.41
3.54
1.0
1.2
—
—
—
0
0
34
178
2.16
3.54
2.5
2.3
0.6
0.8
e6/l
0.17
13
96
6
6
10.32
3.52
1.3
1.2
10.2
14.8
u/l
—
6
6
61
400
1.85
3.35
4.3
3.1
28.1
29.5
u/l
0.25
56
378
83
602
1.79
3.25
3.1
2.8
82.9
84.0
ug/l
0.04
78
564
122
997
1.96
3.21
4.3
4.1
14.5
14.5
pmol/l
0.05
113
922
5
5
10.26
3.00
1.8
1.0
2230.8
966.0
miu/ml
—
5
5
60
408
1.76
2.84
3.9
2.8
—
—
—
0
0
5
6
8.55
2.77
1.2
1.2
—
—
—
0
0
10
32
3.27
2.69
1.3
1.7
45.7
41.0
nmol/l
—
10
32
145
1292
2.39
2.59
19.5
11.9
15.1
20.5
mg/l
2.34
124
1006
5
7
7.33
2.56
1.6
1.0
—
—
—
0
0
41
256
1.81
2.56
3.3
2.3
—
—
—
0
0
38
234
1.82
2.47
3.1
2.1
—
—
—
0
0
68
497
1.64
2.39
2.5
2.4
75.2
75.5
nmol/l
0.03
63
454
5
9
5.69
2.23
2.6
3.4
—
—
—
0
0
19
95
2.14
2.21
4.1
11.6
13.1
12.3
kpa
0.35
19
89
19
95
2.14
2.21
4.1
11.6
4.9
5.0
kpa
0.17
19
89
70
523
1.60
2.21
7.8
7.2
1.2
1.2
mmol/l
1.59
63
439
14
62
2.38
2.14
1.1
1.3
—
—
—
0
0
64
474
1.59
2.07
6.7
6.6
1.2
1.2
mmol/l
1.95
59
437
46
315
1.65
2.04
3.4
2.5
0.1
0.5
e6/l
1.75
31
238
5
11
4.65
1.95
1.0
1.1
—
—
—
0
0
5
11
4.65
1.95
1.0
1.1
—
—
—
0
0
11
46
2.49
1.90
4.7
3.7
25.3
24.9
mmol/l
0.13
11
46
133
1185
1.75
1.84
5.4
4.8
1.8
1.8
mu/l
0.03
126
1101
59
439
1.55
1.83
2.2
1.8
93.4
95.3
pmol/l
0.12
33
217
53
388
1.55
1.76
3.1
3.2
2.3
2.3
mmol/l
1.41
48
344
45
321
1.56
1.66
1.2
1.3
0.6
1.1
u/ml
—
9
102
10
43
2.41
1.64
1.2
1.1
—
—
—
0
0
10
43
2.41
1.64
1.2
1.1
—
—
—
0
0
7
26
2.77
1.60
1.0
1.2
—
—
—
0
0
7
27
2.66
1.53
1.3
2.7
189.3
193.4
%
—
7
27
134
1215
1.65
1.50
18.8
12.0
39.9
40.4
%
0.29
105
973
10
45
2.30
1.50
2.9
2.0
—
—
—
0
0
5
16
3.19
1.45
1.2
1.7
—
—
—
0
0
5
16
3.19
1.45
1.0
1.7
—
—
—
0
0
5
16
3.19
1.45
1.0
1.7
—
—
—
0
0
6
22
2.79
1.45
1.2
1.5
—
—
—
0
0
21
128
1.74
1.42
3.8
1.8
—
—
—
0
0
7
29
2.48
1.41
1.1
1.4
—
—
—
0
0
14
75
1.95
1.39
3.8
5.9
1.1
1.5
mmol/l
0.85
14
69
5
17
3.00
1.37
1.2
1.6
—
—
—
0
0
5
17
3.00
1.37
1.2
1.6
—
—
—
0
0
5
17
3.00
1.37
1.0
1.6
—
—
—
0
0
8
34
2.42
1.31
1.5
1.2
—
—
—
0
0
116
1033
1.45
1.28
3.9
3.7
—
—
—
0
0
6
26
2.36
1.20
1.0
1.3
350.3
273.6
u/ml
—
6
16
22
143
1.62
1.19
3.2
2.3
2.3
2.5
g/l
0.83
22
129
70
578
1.38
1.17
4.4
4.2
—
—
—
0
0
137
1269
1.58
1.16
20.3
12.5
3.9
3.9
mmol/l
0.42
137
1227
8
40
2.05
1.14
5.0
2.8
—
—
—
0
0
131
1205
1.49
1.12
3.9
3.8
5.7
5.7
mmol/l
0.37
123
1122
145
1366
1.70
1.08
13.7
9.1
25.3
25.2
u/l
0.03
145
1326
43
331
1.41
1.07
1.8
1.7
—
—
—
0
0
7
33
2.17
1.07
1.1
2.5
—
—
—
0
0
15
92
1.70
1.01
5.4
3.7
2.2
76.7
ug/l
—
10
78
6
28
2.19
0.92
1.2
1.4
—
—
—
0
0
6
28
2.19
0.92
1.0
1.3
—
—
—
0
0
75
652
1.28
0.81
6.6
4.8
0.0
0.0
estimate
—
10
137
75
652
1.28
0.81
4.6
3.5
0.0
0.0
estimate
—
9
140
12
75
1.65
0.77
1.0
1.0
—
—
—
0
0
6
34
1.79
0.77
1.2
1.1
—
1.1
—
0
5
128
1199
1.35
0.74
15.3
10.4
89.5
88.5
ml/min/173m2
0.19
119
964
5
26
1.95
0.71
3.0
3.2
22.3
22.6
mmol/l
—
5
21
5
26
1.95
0.71
1.2
1.7
—
—
—
0
0
12
77
1.60
0.71
1.5
1.7
—
—
—
0
0
75
661
1.25
0.70
4.6
3.6
0.0
0.0
estimate
—
10
134
18
129
1.45
0.67
9.5
7.1
1.0
1.1
mmol/l
0.20
18
117
15
104
1.49
0.65
3.7
3.4
—
—
—
0
0
5
29
1.75
0.64
1.4
1.2
—
—
—
0
0
22
166
1.38
0.63
5.0
1.9
—
—
—
0
0
34
275
1.30
0.62
1.4
1.4
24.0
22.1
nmol/l
0.50
27
228
128
1209
1.30
0.61
3.2
3.4
1.2
1.2
mmol/l
0.75
118
1128
34
276
1.29
0.61
1.7
2.0
—
—
—
0
0
38
316
1.27
0.57
1.4
1.5
—
—
—
0
0
9
61
1.50
0.55
5.8
13.8
25.0
24.1
mmol/l
—
9
55
17
126
1.39
0.54
1.2
1.3
25.6
117.4
iu/ml
—
5
50
119
1124
1.23
0.50
4.8
4.8
37.5
38.7
mmol/mol
1.04
113
1064
8
59
1.37
0.41
1.3
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.5
—
13.6
—
0
19
30
349
0.83
0.37
5.9
3.9
0.0
0.0
estimate
—
10
131
150
1467
1.40
0.37
26.9
17.4
134.5
135.3
g/l
0.32
150
1446
33
286
1.19
0.35
4.1
3.8
17.7
12.8
mg/mmol
0.15
17
179
6
47
1.29
0.32
3.5
3.1
53.2
48.6
%
—
6
47
29
250
1.20
0.32
1.3
1.3
9.8
27.4
iu/ml
—
8
88
7
54
1.31
0.31
3.4
8.3
1.2
1.6
%
—
7
54
11
86
1.30
0.27
1.2
1.3
—
—
—
0
0
55
508
1.13
0.26
5.2
3.6
—
—
—
0
0
5
41
1.23
0.22
1.0
1.3
—
10.1
—
0
10
130
1267
1.14
0.22
3.7
3.8
4.7
4.7
mmol/l
0.15
125
1193
11
134
0.81
0.21
3.1
4.0
26.2
31.8
%
—
5
86
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
5.0
—
0
10
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
4.1
—
22.6
—
0
14
18
156
1.17
0.19
1.8
1.6
—
—
—
0
0
20
176
1.16
0.18
3.3
3.9
28.9
22.7
%
—
9
81
5
65
0.76
0.17
1.6
1.4
—
—
—
0
0
27
245
1.12
0.16
1.2
1.3
1.5
12.0
u/ml
—
10
96
6
79
0.75
0.16
1.7
1.6
—
—
—
0
0
129
1264
1.11
0.15
3.7
3.7
1.5
1.5
mmol/l
0.07
122
1186
12
139
0.85
0.14
1.4
1.5
—
—
—
0
0
11
127
0.86
0.13
9.6
6.5
—
—
—
0
0
15
135
1.12
0.10
2.0
2.8
0.8
0.7
ug/l
—
9
87
5
45
1.11
0.10
1.4
1.3
—
—
—
0
0
130
1282
1.08
0.09
4.3
4.0
2.7
2.8
mmol/l
0.64
125
1199
7
64
1.10
0.08
2.4
2.9
4.9
5.0
kpa
—
7
58
6
73
0.82
0.08
1.7
1.9
5.7
2.6
ug/l
—
6
63
8
74
1.09
0.07
1.5
1.5
—
—
—
0
0
10
90
1.12
0.05
2.2
2.6
221.3
4511.2
u/l
—
5
39
0
6
0.00
0.00
0.0
1.2
—
0.3
—
0
6
0
6
0.00
0.00
0.0
1.7
—
54.0
—
0
6
7
72
0.97
0.00
1.3
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
10.2
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
30
300
1.00
0.00
1.8
2.8
329.3
8410.0
umol/l
1.73
25
267
0
5
0.00
0.00
0.0
1.0
—
24.0
—
0
5
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
217.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
7
72
0.97
0.00
1.3
1.5
—
—
—
0
0
7
72
0.97
0.00
1.3
1.5
—
—
—
0
0
5
49
1.02
0.00
2.6
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_MENINGVIR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have G6_MENINGVIR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: G6_MENINGVIR – Meningitis, viral
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data