peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
213 |
4. Check minimum number of eventsNone |
213 |
5. Include endpointsNone |
213 |
6. Filter based on genotype QC (FinnGen only) |
213 |
Control definitions (FinnGen only)
- Control exclude
- G6_POLYNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G60-G64
- Name in latin
- Aliae morbositates systematis nervosi peripherici
Similar endpoints
↥List of similar endpoints to
Other disorders of peripheral nervous system
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1252 | 584 | 661 |
| Only index persons | 1109 | 536 | 573 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 59.48 | 59.38 | 59.73 |
| Only index persons | 57.53 | 58.02 | 57.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 213 | 116 | 97 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 58.80 | 56.40 | 61.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 194
- Matched controls
- 1941
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G64
ICD-10 Finland
Other disorders of peripheral nervous system
+∞
277.5
193
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
226.9
37.2
37
*
N03AX12
ATC
gabapentin; oral
5.9
21.2
68
163
N03AX16
ATC
pregabalin; oral
4.6
18.9
80
255
G62.8
ICD-10 Finland
Other specified polyneuropathies
+∞
13.7
13
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.2
12.0
33
62
TAB00
NOMESCO Finland
Lumbar puncture
8.7
11.3
24
31
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
6.1
10.6
29
54
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.6
8.9
89
477
N02AX02
ATC
tramadol; systemic, rectal
2.5
8.8
98
557
N06AX21
ATC
duloxetine; oral
3.9
8.5
36
107
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
4.3
8.5
32
86
N03AE01
ATC
clonazepam; systemic
5.8
8.3
23
44
M48.0
ICD-10 Finland
Spinal stenosis
3.8
7.5
32
96
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
14.1
7.5
12
9
R20.2
ICD-10 Finland
Paraesthesia of skin
4.8
7.5
24
55
M54.2
ICD-10 Finland
Cervicalgia
4.7
7.3
24
56
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
5.3
7.2
21
43
L28
ICPC
Limited function/disability (L)
3.1
7.2
43
164
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
7.1
35
119
M79.6
ICD-10 Finland
Pain in limb
2.3
6.8
79
444
N06AA09
ATC
amitriptyline; systemic
3.4
6.7
32
106
N06AX11
ATC
mirtazapine; oral
2.3
6.4
72
395
G60.0
ICD-10 Finland
Hereditary motor and sensory neuropathy
+∞
6.3
6
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
27.6
6.3
8
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.7
6.2
26
78
R52.9
ICD-10 Finland
Pain, unspecified
3.6
6.1
27
84
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.7
6.0
25
74
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
16
15
11.45
14.82
1.2
1.1
—
—
—
0
0
30
60
5.66
14.80
3.5
1.7
9.1
10.6
g/l
0.79
23
52
15
13
12.34
14.58
1.1
1.1
—
—
—
0
0
31
65
5.41
14.53
3.6
1.7
4.7
3.7
g/l
0.39
22
48
31
65
5.41
14.53
3.6
1.7
6.8
7.4
g/l
1.03
22
52
31
65
5.41
14.53
3.6
1.7
—
—
—
0
0
30
62
5.47
14.28
3.7
1.7
2.8
3.3
g/l
2.10
22
49
14
13
11.46
12.99
1.2
1.0
—
—
—
0
0
123
684
2.89
12.97
2.4
1.9
96.4
95.1
pmol/l
0.11
69
343
104
540
2.81
12.34
2.6
2.0
200.6
198.8
u/l
0.01
96
505
21
38
6.02
11.41
1.2
1.2
5.1
170.3
e6/l
0.54
15
30
21
38
6.02
11.41
1.2
1.1
1.5
2.6
e6/l
0.83
15
27
15
7
22.90
10.84
1.2
1.0
—
—
—
0
0
122
753
2.45
9.34
6.0
4.3
35.6
35.6
g/l
0.02
114
707
125
781
2.45
9.30
11.8
5.9
1.2
1.2
mmol/l
0.18
117
702
59
267
2.67
8.69
4.4
3.4
0.8
0.8
mmol/l
1.33
53
246
130
851
2.35
8.37
8.1
7.0
1.2
1.2
mmol/l
0.33
112
715
71
369
2.39
7.70
1.3
1.2
1.9
1.5
u/ml
0.09
11
101
144
1006
2.33
7.67
10.6
10.1
4.2
4.1
e9/l
0.35
130
876
97
587
2.20
7.24
4.1
3.5
2.4
2.4
mmol/l
0.18
88
512
107
677
2.17
7.09
2.5
2.2
78.6
76.7
nmol/l
0.29
95
596
73
399
2.26
6.94
2.6
2.0
2.5
3.4
mg/l
3.23
64
340
134
945
2.13
6.48
7.6
6.6
10.3
10.8
umol/l
0.45
129
892
14
32
4.61
5.86
1.1
1.3
—
—
—
0
0
14
32
4.61
5.86
1.1
1.3
—
—
—
0
0
43
200
2.44
5.82
1.8
1.6
—
—
—
0
0
60
326
2.17
5.65
1.7
1.7
1038.4
1239.2
nmol/l
0.90
51
241
106
712
1.97
5.57
3.5
2.5
124.1
127.9
ug/l
0.06
100
644
72
425
2.05
5.43
2.0
1.6
19.8
21.0
nmol/l
0.31
65
356
40
186
2.42
5.40
2.0
5.2
249.9
245.2
u/l
0.08
35
176
64
365
2.08
5.28
1.8
1.7
0.9
1.3
mg/l
0.73
44
292
164
1303
2.12
5.12
5.8
4.1
13.3
12.1
mm/h
0.48
156
1187
53
289
2.11
4.88
1.9
1.8
—
—
—
0
0
35
162
2.39
4.76
2.7
2.3
90.4
29.9
u/l
0.47
27
137
32
143
2.46
4.69
5.1
6.7
8.5
9.5
mmol/l
0.38
32
136
41
205
2.24
4.67
1.8
1.7
—
—
—
0
0
150
1176
1.93
4.57
3.8
3.0
57.5
45.9
u/l
0.59
141
1102
51
284
2.05
4.41
3.8
2.6
0.9
0.9
e6/l
0.06
31
157
17
56
3.21
4.35
1.2
1.9
—
—
—
0
0
48
265
2.05
4.24
4.1
2.9
3.4
2.4
e6/l
0.26
28
142
86
584
1.79
4.04
4.6
3.3
33.7
29.9
u/l
0.48
81
559
75
489
1.82
4.02
4.2
2.8
0.5
0.3
e6/l
0.58
64
361
13
40
3.40
3.69
1.2
1.3
—
—
—
0
0
23
99
2.48
3.65
1.3
1.3
—
—
—
0
0
42
233
2.00
3.64
2.5
2.3
23.6
22.9
%
0.10
35
199
116
877
1.71
3.61
3.6
3.7
0.0
0.0
estimate
0.00
19
156
14
46
3.19
3.60
1.4
1.3
8.6
1.6
u/ml
—
6
11
89
627
1.72
3.58
4.5
3.1
—
—
—
0
0
60
379
1.81
3.51
1.7
1.8
413.2
445.5
pmol/l
0.50
53
312
114
868
1.67
3.38
4.5
4.9
0.0
0.0
estimate
0.00
20
161
157
1312
1.75
3.19
3.9
3.9
15.2
14.9
pmol/l
0.69
141
1181
183
1605
2.00
3.13
5.3
4.7
1.6
1.9
mu/l
3.01
169
1453
58
376
1.75
3.07
3.3
4.1
1.0
1.0
kg/l
0.21
11
51
6
8
7.67
3.07
1.0
1.4
2.0
2.0
mmol/l
—
6
8
14
51
2.87
3.05
1.2
2.0
1.6
3.9
mg/l
—
9
35
52
332
1.75
2.89
6.0
3.4
365.1
143.3
ng/l
0.47
43
258
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
9
6.82
2.88
1.0
1.2
—
—
—
0
0
22
105
2.22
2.80
1.8
1.6
—
—
—
0
0
5
6
8.49
2.76
1.0
1.5
—
—
—
0
0
5
6
8.49
2.76
1.0
1.2
—
—
—
0
0
93
698
1.59
2.76
4.9
3.8
78.3
38.0
ng/l
0.39
69
490
110
859
1.58
2.75
3.6
3.7
0.0
0.0
estimate
0.00
20
166
192
1746
2.01
2.44
23.9
14.0
23.3
22.9
mg/l
0.05
167
1384
5
9
5.66
2.22
1.0
1.2
—
—
—
0
0
33
202
1.75
2.11
16.8
7.8
1.9
1.1
mmol/l
0.47
24
158
102
822
1.46
2.00
5.2
3.9
—
—
—
0
0
45
306
1.60
1.95
1.3
1.3
32.5
36.0
iu/ml
0.09
13
95
6
16
3.83
1.95
1.2
1.1
—
—
—
0
0
6
16
3.83
1.95
1.5
3.9
—
—
—
0
0
13
60
2.24
1.82
1.5
1.4
—
—
—
0
0
13
60
2.24
1.82
1.9
1.5
—
—
—
0
0
185
1701
1.67
1.75
4.8
4.7
6.2
6.0
mmol/l
0.73
173
1546
13
62
2.17
1.69
1.5
1.5
—
—
—
0
0
15
77
2.02
1.63
1.9
3.7
25.0
24.1
mmol/l
0.57
15
68
62
471
1.45
1.60
2.0
2.9
329.2
8573.1
umol/l
2.44
55
401
23
138
1.75
1.59
3.1
3.0
56.1
60.6
ml/min/173m2
—
9
60
7
26
2.75
1.59
1.1
1.3
—
—
—
0
0
8
33
2.48
1.55
1.1
1.1
—
—
—
0
0
12
58
2.13
1.52
3.7
2.4
—
—
—
0
0
57
431
1.44
1.50
3.2
2.2
—
—
—
0
0
197
1857
1.81
1.49
28.4
16.8
74.9
77.7
umol/l
0.85
197
1857
25
159
1.65
1.42
2.5
3.9
5.9
5.7
kpa
0.55
25
154
121
1046
1.36
1.42
3.4
3.0
—
—
—
0
0
40
286
1.49
1.39
1.3
1.3
1.1
8.1
u/ml
2.03
14
103
9
41
2.25
1.39
1.0
1.4
—
—
—
0
0
61
474
1.40
1.37
1.6
1.6
1.5
1.4
mmol/l
0.28
56
387
6
24
2.54
1.31
1.2
1.1
—
—
—
0
0
82
676
1.35
1.27
3.2
3.8
—
—
—
0
0
6
25
2.44
1.25
1.2
1.6
—
—
—
0
0
9
45
2.04
1.25
1.0
1.1
—
—
—
0
0
5
19
2.67
1.22
1.0
1.3
—
—
—
0
0
6
26
2.34
1.19
1.2
1.7
—
—
—
0
0
6
26
2.34
1.19
1.2
1.7
—
—
—
0
0
6
26
2.34
1.19
1.2
1.7
—
—
—
0
0
6
26
2.34
1.19
1.2
1.7
—
—
—
0
0
10
50
2.05
1.18
1.0
1.3
—
—
—
0
0
5
20
2.53
1.15
3.4
2.9
—
—
—
0
0
13
73
1.83
1.13
1.8
1.6
—
—
—
0
0
8
40
2.04
1.13
1.3
1.4
—
—
—
0
0
171
1587
1.39
1.12
25.4
14.9
40.4
40.1
%
0.23
121
1139
8
41
1.99
1.10
1.3
1.1
—
—
—
0
0
5
21
2.41
1.09
1.2
1.0
—
—
—
0
0
7
33
2.16
1.06
2.4
1.5
—
—
—
0
0
5
22
2.30
1.04
1.4
1.2
—
—
—
0
0
177
1659
1.40
1.03
21.9
13.2
80.4
79.9
ml/min/173m2
0.10
151
1369
20
132
1.57
1.01
2.3
2.9
4.7
4.3
kpa
0.38
20
127
19
124
1.58
1.01
2.3
3.9
73.8
80.5
ng/l
0.19
14
108
7
36
1.98
0.98
1.7
1.6
—
—
—
0
0
30
219
1.43
0.96
4.4
4.5
31.0
27.5
ug/l
0.04
24
178
18
118
1.57
0.94
1.5
1.5
—
—
—
0
0
6
27
2.26
0.94
1.2
1.6
—
—
—
0
0
8
42
1.94
0.89
1.1
1.5
—
—
—
0
0
8
43
1.89
0.88
1.0
1.7
—
—
—
0
0
15
97
1.59
0.84
9.3
7.5
24.9
25.1
mmol/l
0.05
15
97
6
32
1.90
0.82
1.5
6.7
—
150.5
—
0
6
57
473
1.28
0.82
4.1
4.0
0.0
0.0
estimate
0.00
20
159
175
1657
1.31
0.78
6.5
5.9
40.7
40.2
mmol/mol
0.25
168
1541
5
26
1.94
0.71
1.0
1.4
—
—
—
0
0
14
94
1.52
0.68
2.2
2.6
1.8
1.1
%
1.31
14
94
7
44
1.61
0.66
1.0
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
2.1
—
—
—
0
0
0
20
0.00
0.60
0.0
2.2
—
—
—
0
0
0
20
0.00
0.60
0.0
2.1
—
—
—
0
0
8
53
1.53
0.59
1.5
1.8
291.0
317.4
mu/l
—
8
47
8
55
1.47
0.56
1.1
1.7
—
—
—
0
0
11
157
0.68
0.53
1.6
1.7
—
—
—
0
0
184
1777
1.26
0.51
5.3
5.1
2.6
2.8
mmol/l
1.30
174
1625
13
93
1.42
0.49
1.0
1.0
—
—
—
0
0
7
45
1.57
0.49
1.1
1.4
—
—
—
0
0
54
475
1.18
0.45
3.5
4.6
22.0
21.7
%
0.05
20
227
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
180
1745
1.20
0.40
4.6
4.6
4.5
4.7
mmol/l
1.86
170
1610
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
8
61
1.32
0.40
2.3
2.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.9
—
—
—
0
0
179
1737
1.19
0.38
4.5
4.5
1.4
1.5
mmol/l
1.13
166
1594
12
155
0.76
0.34
3.1
1.8
—
—
—
0
0
6
45
1.34
0.34
1.0
1.1
—
3.4
—
0
7
25
212
1.20
0.32
9.1
8.2
—
—
—
0
0
7
98
0.70
0.31
3.0
2.9
12.6
46.5
u/ml
—
7
93
20
166
1.23
0.31
3.2
3.5
—
—
—
0
0
65
600
1.12
0.28
4.6
4.9
1.7
2.2
ug/l
0.65
59
535
8
65
1.24
0.27
2.3
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
3.5
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
5
43
1.17
0.21
1.2
1.2
0.7
0.9
nmol/l
—
5
36
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
2.9
—
0
7
171
1677
1.10
0.18
4.4
4.1
1.3
1.3
mmol/l
0.22
161
1531
12
141
0.84
0.17
2.6
1.7
—
—
—
0
0
7
90
0.77
0.14
1.0
1.3
—
—
—
0
0
37
348
1.08
0.11
2.7
2.9
0.7
0.7
ug/l
0.18
28
222
5
44
1.14
0.10
1.8
1.3
—
—
—
0
0
28
271
1.04
0.02
1.5
1.5
—
—
—
0
0
25
251
1.00
0.00
1.1
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
9.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
23
230
1.00
0.00
4.9
4.8
34.0
31.2
%
0.44
17
150
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_PERIPHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PERIPHOTH | 1.811 [1.42, 2.32] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.162 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 508 females with G6_PERIPHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PERIPHOTH | 2.226 [1.7, 2.91] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 563 males with G6_PERIPHOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_PERIPHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.178% | 0.322% |
| 5 | 0.962% | 2.451% |
| 10 | 2.551% | 6.395% |
| 15 | 4.571% | 12.048% |
| 20 | 7.489% | 19.046% |
Relationships between endpoints
↥Index endpoint: G6_PERIPHOTH – Other disorders of peripheral nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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