Discontinuity and dislocation of ear ossicles

H8_DISCON

Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H74.2
  • Cause of death: ICD-10 H74.2

2 out of 7 registries used, show all original rules.

202

4. Check minimum number of events

None

202

5. Include endpoints

None

202

6. Filter based on genotype QC (FinnGen only)

190

Control definitions (FinnGen only)

Control exclude
H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H74
Name in latin
Discontinuitas ossiculorum auditoriorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1329 614 704
Only index persons 1268 593 675
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.03
Median age at first event (years)
Whole population 44.71 48.15 41.81
Only index persons 45.31 48.21 42.77

-FinnGen-

Key figures

All Female Male
Number of individuals 190 100 90
Unadjusted period prevalence (%) 0.04 0.04 0.04
Median age at first event (years) 52.35 50.35 54.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
202
Matched controls
2020
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
292.4
202
*
DFF00
NOMESCO Finland
Pure tone audiometry
20.4
103.8
104
100
DCD10
NOMESCO Finland
Tympanoplasty
+∞
98.1
86
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
334.9
85.6
81
*
UDC00
NOMESCO Finland
Ear microscopy
16.1
72.6
74
70
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
64.0
58
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
+∞
61.7
56
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
10.1
57.7
89
146
DC1AD
NOMESCO Finland
Temporalbone CT
287.5
46.0
45
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
34.4
32
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
34.4
32
*
DFF15
NOMESCO Finland
Speech audiometry
9.9
30.2
38
46
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
323.9
28.5
28
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.5
28.3
41
59
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
112.3
27.4
29
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
52.0
26.4
31
7
DCD00
NOMESCO Finland
Myringoplasty
+∞
24.5
23
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
22.3
21
*
ZXC10
NOMESCO Finland
Use of laser
19.5
21.8
33
20
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
85.8
21.2
23
*
Z3229
NOMESCO Finland
Other healthcare associate professional
6.3
20.6
39
74
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
7.3
19.4
31
49
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
19.1
18
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
208.6
18.9
19
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
18.0
17
*
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
16.9
16
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
16.0
78
306
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
15.8
15
*
DAX08
NOMESCO Finland
Fitting of hearing aid
5.9
14.4
28
54
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
46.2
14.3
17
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
6.2
13.7
25
45
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
13.7
13
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
13.7
13
*
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
30.7
13.2
17
6
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
+∞
12.6
12
*
H80.9
ICD-10 Finland
Otosclerosis, unspecified
28.8
12.2
16
6
H29
ICPC
Ear symptom/complaint other
4.1
12.0
37
105
WX110
NOMESCO Finland
Infiltration anesthesia
3.7
11.4
169
1179
H66.9
ICD-10 Finland
Otitis media, unspecified
5.8
11.3
22
42
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
11.5
11.1
20
19
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.1
10.9
20
36
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
+∞
10.5
10
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
10.5
10
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
34.5
10.5
13
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.1
9.5
47
180
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
9.4
9
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
9.4
9
*
WX704
NOMESCO Finland
Intubation
4.2
9.4
27
72
H60.9
ICD-10 Finland
Otitis externa, unspecified
4.4
9.1
24
60
DDA00
NOMESCO Finland
Stapedotomy
25.4
9.0
12
5
ZXA00
NOMESCO Finland
Right side
2.6
8.8
66
315
4122
FHL
Tympanostomy (tympanic tube)
+∞
8.4
8
*
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
+∞
8.4
8
*
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
8.4
8
*
WX002
NOMESCO Finland
Sedation and analgesia
2.8
8.3
49
206
H01
ICPC
Ear pain/earache
3.1
7.7
35
127
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
7.3
7
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
+∞
7.3
7
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
7.3
7
*
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
+∞
7.3
7
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
7.3
7
*
ZZG00
NOMESCO Finland
Graft of cartilage
+∞
7.3
7
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
31.2
7.2
9
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.7
7.1
17
39
WX725
NOMESCO Finland
Noninvasive ventilation
4.2
6.9
19
49
H69.0
ICD-10 Finland
Patulous Eustachian tube
41.5
6.8
8
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
+∞
6.3
6
*
H90.2
ICD-10 Finland
Conductive hearing loss, unspecified
+∞
6.3
6
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
6.3
6
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
+∞
6.3
6
*
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
6.3
6
*
H61.8
ICD-10 Finland
Other specified disorders of external ear
27.6
6.3
8
*
WX720
NOMESCO Finland
Own respiration
4.4
6.2
16
39
ZXA05
NOMESCO Finland
Left side
2.3
6.1
55
280

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
160
3.05
8.54
2.5
1.6
—
—
—
0
0
20
67
3.20
4.99
12.6
8.4
—
—
—
0
0
33
177
2.03
3.14
1.8
1.4
—
—
—
0
0
83
593
1.68
3.13
1.9
1.8
104.18
96.01
pmol/l
0.43
36
287
91
672
1.64
2.99
6.8
5.5
1.21
1.21
mmol/l
0.19
83
617
46
282
1.82
2.96
4.1
3.5
111.72
226.13
ng/l
0.43
37
196
53
765
0.58
2.85
10.4
8.8
0.00
0.00
e9/l
0.39
45
612
96
728
1.61
2.78
6.9
6.5
1.21
1.21
mmol/l
0.09
82
622
12
45
2.77
2.50
4.9
2.5
—
—
—
0
0
46
649
0.62
2.10
2.5
2.7
—
—
—
0
0
17
85
2.09
1.97
7.0
4.7
—
—
—
0
0
137
1182
1.49
1.90
3.1
2.9
51.54
46.86
u/l
0.26
130
1110
23
131
1.85
1.87
2.0
4.7
—
—
—
0
0
33
215
1.64
1.71
1.6
1.8
—
—
—
0
0
31
457
0.62
1.66
2.8
3.2
—
—
—
0
0
138
1214
1.43
1.56
4.0
3.9
12.58
10.79
mm/h
0.61
130
1130
32
212
1.61
1.56
2.1
2.3
233.69
121.60
ug/g
0.29
25
172
25
157
1.68
1.49
1.7
1.7
—
—
—
0
0
48
357
1.45
1.39
1.6
1.5
18.81
21.48
nmol/l
0.74
41
307
5
17
2.99
1.36
1.2
1.1
—
—
—
0
0
5
115
0.42
1.30
4.8
3.9
1.25
1.23
mmol/l
—
5
106
139
1244
1.38
1.29
6.3
7.4
79.28
79.57
u/l
0.02
127
1164
35
475
0.68
1.25
4.7
2.8
96.79
41.76
e6/l
0.32
27
360
46
347
1.42
1.23
2.0
2.0
2.19
3.16
mg/l
2.72
38
302
35
251
1.48
1.21
1.4
1.6
892.18
1161.54
nmol/l
1.27
28
192
5
20
2.54
1.16
1.6
1.3
—
—
—
0
0
7
31
2.30
1.11
2.1
1.3
—
—
—
0
0
11
59
1.91
1.09
1.4
1.6
—
—
—
0
0
5
22
2.30
1.04
1.4
1.3
—
—
—
0
0
18
116
1.61
1.00
1.6
1.4
—
—
—
0
0
61
500
1.32
0.97
2.6
2.4
57.33
65.49
u/l
0.34
55
457
168
1580
1.38
0.91
4.5
4.3
5.74
5.89
mmol/l
0.96
152
1462
6
29
2.10
0.90
2.5
1.9
72.07
64.77
%
—
6
29
23
162
1.47
0.89
8.5
6.2
103.96
103.62
mmol/l
0.16
23
162
120
1082
1.27
0.89
5.0
3.9
—
—
—
0
0
96
845
1.26
0.86
4.1
6.2
9.88
11.24
umol/l
0.88
90
801
6
111
0.53
0.86
2.8
2.2
—
—
—
0
0
184
1762
1.50
0.85
12.1
11.2
—
—
—
0
0
6
31
1.96
0.85
1.3
1.5
3555.33
14627.43
e6/l
—
6
21
161
1510
1.33
0.85
4.8
4.5
1.77
1.89
mu/l
0.75
145
1385
51
416
1.30
0.84
2.7
3.6
—
—
—
0
0
15
97
1.59
0.84
1.1
1.2
—
—
—
0
0
34
430
0.75
0.79
4.9
2.7
0.18
0.38
e6/l
1.30
27
314
85
747
1.24
0.75
7.0
5.8
0.73
0.65
%
0.62
79
698
176
1680
1.37
0.75
15.4
13.7
139.71
139.70
mmol/l
0.02
170
1640
5
24
2.11
0.75
1.0
1.1
—
—
—
0
0
9
143
0.61
0.73
1.2
1.3
—
—
—
0
0
9
58
1.58
0.71
3.2
3.7
—
—
—
0
0
5
91
0.54
0.69
1.4
1.7
—
—
—
0
0
78
687
1.22
0.66
2.9
2.6
129.39
113.32
ug/l
0.36
72
636
186
1798
1.44
0.66
9.9
9.8
29.11
28.02
u/l
0.20
179
1752
61
526
1.23
0.63
4.5
4.6
1.64
1.97
ug/l
0.64
54
473
5
30
1.68
0.62
1.2
3.8
—
—
—
0
0
176
1691
1.32
0.61
15.6
13.7
3.98
3.97
mmol/l
0.33
170
1645
43
359
1.25
0.60
3.4
3.1
—
—
—
0
0
159
1511
1.25
0.60
5.3
5.3
38.76
39.55
mmol/mol
0.60
148
1411
0
22
0.00
0.59
0.0
1.9
—
91.02
—
0
22
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
6
35
1.74
0.58
3.5
2.4
—
—
—
0
0
174
1672
1.29
0.58
5.0
4.7
2.89
2.79
mmol/l
0.81
159
1562
29
357
0.78
0.56
1.2
1.5
2.83
2.53
g/l
0.44
18
218
19
143
1.36
0.55
1.3
1.2
—
—
—
0
0
34
409
0.80
0.54
1.4
1.3
0.64
0.87
u/ml
—
8
117
36
430
0.80
0.54
4.7
2.6
—
—
—
0
0
57
498
1.20
0.52
1.8
2.2
—
—
—
0
0
131
1234
1.18
0.48
4.0
3.9
14.44
14.69
pmol/l
0.62
119
1119
16
122
1.34
0.44
13.1
6.6
—
—
—
0
0
5
32
1.58
0.42
1.4
1.0
—
—
—
0
0
49
553
0.85
0.41
5.1
3.3
27.09
61.88
e6/l
0.77
31
386
77
703
1.15
0.41
10.7
10.2
1.15
1.17
inr
0.10
17
206
0
15
0.00
0.41
0.0
3.1
—
46.71
—
0
7
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
434.00
—
0
10
33
280
1.21
0.41
1.3
1.3
66.79
24.80
iu/ml
—
7
100
0
17
0.00
0.41
0.0
1.8
—
1.00
—
0
11
0
17
0.00
0.41
0.0
1.2
—
182.52
—
0
17
11
148
0.73
0.40
3.1
2.1
9.95
14.86
nmol/l
1.36
11
143
18
142
1.29
0.40
4.8
3.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.6
—
—
—
0
0
5
35
1.44
0.39
1.4
1.3
—
—
—
0
0
105
1117
0.88
0.39
4.5
3.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
2.6
—
—
—
0
0
0
19
0.00
0.39
0.0
2.6
—
3.97
—
0
19
0
19
0.00
0.39
0.0
2.6
—
106.00
—
0
19
89
826
1.14
0.37
6.5
5.9
0.05
0.04
e9/l
1.20
81
721
170
1649
1.20
0.37
4.6
4.3
4.87
4.69
mmol/l
1.49
157
1549
10
73
1.39
0.35
3.2
2.3
—
—
—
0
0
12
91
1.34
0.34
1.1
1.3
—
—
—
0
0
169
1642
1.18
0.33
4.5
4.2
1.47
1.46
mmol/l
0.13
155
1532
17
137
1.26
0.33
4.7
3.6
5.94
5.76
kpa
0.29
17
132
165
1601
1.17
0.33
3.9
3.8
1.29
1.31
mmol/l
0.11
152
1478
50
450
1.15
0.32
2.2
2.0
166.13
206.92
u/l
0.33
45
427
31
355
0.85
0.31
2.1
1.9
—
—
—
0
0
10
129
0.76
0.29
1.2
1.4
—
—
—
0
0
47
429
1.12
0.25
2.7
2.7
—
—
—
0
0
45
410
1.13
0.25
2.0
1.7
1.47
1.40
mmol/l
0.23
37
350
6
82
0.72
0.24
1.7
1.4
—
—
—
0
0
90
853
1.10
0.24
6.9
6.3
0.20
0.19
e9/l
0.11
83
757
5
39
1.29
0.23
1.4
1.5
—
—
—
0
0
152
1480
1.11
0.22
17.8
15.6
333.49
333.47
g/l
0.01
152
1475
10
124
0.80
0.22
3.4
4.3
1.20
1.19
%
—
5
42
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
68.45
—
0
11
0
10
0.00
0.21
0.0
1.3
—
109.35
—
0
10
0
10
0.00
0.21
0.0
1.6
—
26.78
—
0
10
191
1886
1.23
0.21
19.8
18.0
40.41
40.90
%
0.45
172
1791
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
5
43
1.17
0.21
2.0
1.5
—
—
—
0
0
5
43
1.17
0.21
2.6
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
23.59
—
0
13
42
386
1.11
0.20
3.2
4.2
—
—
—
0
0
6
48
1.26
0.20
3.2
3.4
—
—
—
0
0
67
631
1.09
0.20
2.1
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
38.36
—
0
14
6
50
1.21
0.20
1.2
1.1
—
—
—
0
0
6
51
1.18
0.19
2.0
2.2
—
7057.66
—
0
14
89
852
1.08
0.18
6.7
5.9
2.00
1.91
e9/l
0.31
82
762
5
68
0.73
0.17
2.8
2.2
0.66
0.67
%
—
5
68
5
68
0.73
0.17
1.2
1.4
—
—
—
0
0
5
70
0.71
0.17
2.8
2.2
1.08
1.35
%
—
5
70
86
825
1.07
0.16
6.6
5.9
0.65
0.58
e9/l
1.36
78
719
26
286
0.90
0.16
1.9
1.6
—
—
—
0
0
20
178
1.14
0.16
1.6
1.7
—
—
—
0
0
36
333
1.10
0.16
1.4
1.7
1.07
1.12
mg/l
0.04
27
253
9
78
1.16
0.15
15.9
8.8
93.03
94.19
%
—
9
78
9
81
1.12
0.15
3.1
3.2
130.56
129.10
g/l
—
9
81
49
462
1.08
0.14
1.3
1.5
—
—
—
0
0
13
149
0.86
0.14
2.4
2.3
0.21
0.23
g/l
0.37
13
135
22
200
1.11
0.13
1.2
1.2
—
—
—
0
0
13
114
1.15
0.12
2.5
2.7
4.55
4.70
kpa
0.12
13
108
21
229
0.91
0.11
1.8
1.6
—
—
—
0
0
12
136
0.87
0.11
2.2
1.6
—
—
—
0
0
17
187
0.90
0.10
2.0
1.4
—
—
—
0
0
5
47
1.07
0.09
2.4
3.3
18.18
31.94
mg/l
—
5
39
5
47
1.07
0.09
2.4
3.2
29.38
202.68
mg/l
—
5
38
17
155
1.11
0.09
3.6
2.0
378.47
378.87
nmol/l
0.00
17
144
94
962
0.96
0.08
9.4
9.3
4.05
4.06
e9/l
0.01
85
839
6
57
1.05
0.08
2.5
1.3
—
—
—
0
0
46
441
1.06
0.08
4.5
3.9
14.97
8.20
mg/mmol
0.26
27
266
18
195
0.92
0.08
1.2
1.2
—
—
—
0
0
7
65
1.08
0.08
1.9
1.7
—
—
—
0
0
6
75
0.79
0.07
1.0
1.1
—
—
—
0
0
21
196
1.08
0.07
1.5
1.4
—
—
—
0
0
10
112
0.89
0.07
2.7
4.5
0.00
0.10
%
—
5
31
7
81
0.86
0.07
1.6
1.4
—
—
—
0
0
7
82
0.85
0.07
1.6
1.4
—
—
—
0
0
7
83
0.84
0.07
1.6
1.4
—
—
—
0
0
7
84
0.83
0.07
1.0
1.1
—
—
—
0
0
19
177
1.08
0.07
1.2
1.4
—
—
—
0
0
10
110
0.90
0.05
1.1
1.3
—
31.26
—
0
5
168
1667
1.05
0.05
13.2
12.3
18.35
22.56
mg/l
1.21
131
1269
42
432
0.96
0.04
5.7
7.0
—
—
—
0
0
76
773
0.97
0.04
7.7
6.3
—
—
—
0
0
91
921
0.98
0.03
5.9
4.2
6.78
6.59
mmol/l
0.36
79
858
32
311
1.03
0.02
3.2
2.7
0.67
0.75
ug/l
0.17
21
197
34
349
0.97
0.02
3.6
3.6
1.02
1.02
kg/l
—
9
47
20
192
1.05
0.02
1.6
2.7
4.67
9.88
umol/l
1.58
15
171
25
242
1.04
0.02
4.5
2.7
0.56
2.17
e6/l
1.63
15
130
12
113
1.07
0.02
1.0
1.2
43.00
115.63
iu/ml
—
5
45
46
468
0.98
0.01
4.1
3.1
7.25
7.87
mmol/l
0.55
38
396
59
583
1.02
0.01
2.4
3.5
13.98
26.88
ng/l
4.23
33
385
20
194
1.03
0.00
3.4
2.2
21.94
25.37
%
0.51
13
169
17
166
1.03
0.00
1.7
1.5
—
—
—
0
0
42
416
1.01
0.00
4.5
3.3
116.41
48.01
mg/l
0.41
22
265
10
97
1.03
0.00
1.7
3.6
—
—
—
0
0
26
263
0.99
0.00
1.3
1.2
1.16
5.95
u/ml
—
7
110
51
512
0.99
0.00
2.5
3.3
2.36
2.35
mmol/l
0.20
45
456
10
102
0.98
0.00
2.7
3.6
4.52
4.81
pmol/l
—
10
88
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
59
0.84
0.00
8.4
9.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
2.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
78
0.89
-0.00
2.1
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
31.12
—
0
6
0
6
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.8
—
1939.00
—
0
5
0
5
0.00
-0.00
0.0
5.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
6.39
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
39.29
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
76
0.92
-0.00
1.6
1.4
—
—
—
0
0
9
94
0.96
-0.00
2.3
2.4
—
—
—
0
0
8
88
0.91
-0.00
16.9
5.2
24.44
25.12
mmol/l
—
8
88
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.9
—
5.02
—
0
8
0
5
0.00
-0.00
0.0
2.6
—
23.98
—
0
5
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
190.58
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
1662.40
—
0
5
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H8_DISCON and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_DISCON.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H8_DISCON – Discontinuity and dislocation of ear ossicles

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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