Otitis media: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
192 |
4. Check minimum number of eventsNone |
192 |
5. Include endpointsNone |
192 |
6. Filter based on genotype QC (FinnGen only) |
192 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H74
- Name in latin
- Discontinuitas ossiculorum auditoriorum
Similar endpoints
↥List of similar endpoints to
Discontinuity and dislocation of ear ossicles
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1329 | 614 | 704 |
| Only index persons | 1268 | 593 | 675 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 44.71 | 48.15 | 41.81 |
| Only index persons | 45.31 | 48.21 | 42.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 192 | 103 | 89 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 51.77 | 50.09 | 53.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 167
- Matched controls
- 1671
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
241.5
167
*
DCD10
NOMESCO Finland
Tympanoplasty
+∞
83.5
73
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
243.7
64.0
62
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
49.4
45
*
DFF00
NOMESCO Finland
Pure tone audiometry
20.2
48.5
78
69
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
603.3
47.8
45
*
UDC00
NOMESCO Finland
Ear microscopy
21.7
40.1
61
43
DC1AD
NOMESCO Finland
Temporalbone CT
243.6
38.5
38
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
8.7
28.1
69
124
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
+∞
27.9
26
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
26.8
25
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
79.8
24.6
27
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
63.8
23.9
27
5
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
+∞
23.5
22
*
DCD00
NOMESCO Finland
Myringoplasty
+∞
22.4
21
*
ZXC10
NOMESCO Finland
Use of laser
20.3
19.5
29
17
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
79.3
19.2
21
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
13.9
19.0
33
29
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
16.9
16
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
15.9
15
*
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
15.9
15
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
15.9
15
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
+∞
14.8
14
*
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
43.9
13.4
16
*
H80.9
ICD-10 Finland
Otosclerosis, unspecified
75.7
12.8
14
*
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
12.7
12
*
DFF15
NOMESCO Finland
Speech audiometry
10.2
12.2
24
27
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
+∞
11.6
11
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
11.6
11
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
46.7
11.1
13
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
10.5
10
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
9.7
10.1
20
23
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
42.8
10.1
12
*
DDA00
NOMESCO Finland
Stapedotomy
105.6
9.5
10
*
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
9.5
9
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.1
9.4
39
116
WX110
NOMESCO Finland
Local anesthesy
3.1
8.8
134
947
Z97.4
ICD-10 Finland
Presence of external hearing-aid
10.9
8.7
16
16
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
8.4
8
*
ZXA00
NOMESCO Finland
Right side
2.8
7.8
61
285
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
5.8
7.7
21
40
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
7.6
65
321
H29
ICPC
Ear symptom/complaint other
4.2
7.6
29
80
H01
ICPC
Ear pain/earache
3.9
7.5
31
92
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
7.3
7
*
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
7.3
7
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
7.3
7
*
H69.0
ICD-10 Finland
Patulous Eustachian tube
+∞
7.3
7
*
TDA90
NOMESCO Finland
Removal wax from ear
23.6
6.7
9
*
H66.9
ICD-10 Finland
Otitis media, unspecified
6.7
6.6
16
26
H91.9
ICD-10 Finland
Hearing loss, unspecified
6.4
6.5
16
27
ZZG00
NOMESCO Finland
Graft of cartilage
72.4
6.5
7
*
R5120
NOMESCO Finland
Preparation of an aid
9.8
6.4
12
13
DAX08
NOMESCO Finland
Fitting of hearing aid
7.5
6.4
14
20
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
27.8
6.3
8
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
+∞
6.3
6
*
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
+∞
6.3
6
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
6.3
6
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
+∞
6.3
6
*
38199
ICD-8 Finland
Otitis media without mention of mastoiditis, Unspecified
+∞
6.3
6
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
6.3
6
*
4122
FHL
Tympanostomy (tympanic tube)
+∞
6.3
6
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
6.3
6
*
4141
FHL
Myringoplasty (also for reasons other than inflammation)
+∞
6.3
6
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
10.6
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
87
648
1.63
2.75
5.0
5.3
1.2
1.2
mmol/l
0.21
79
590
31
171
1.97
2.75
4.2
4.2
28.1
31.7
%
1.32
20
102
79
578
1.62
2.67
1.9
1.8
104.2
95.7
pmol/l
0.45
36
282
92
699
1.61
2.66
5.2
6.3
1.2
1.2
mmol/l
0.08
77
592
43
268
1.78
2.62
4.0
3.4
119.6
135.0
ng/l
0.06
34
186
130
1117
1.51
1.89
3.0
3.0
52.3
47.3
u/l
0.26
123
1050
132
1166
1.42
1.45
4.1
3.9
12.4
11.0
mm/h
0.43
125
1086
134
1192
1.41
1.37
5.7
7.3
79.3
78.8
u/l
0.03
122
1114
86
716
1.36
1.30
3.5
3.9
—
—
—
0
0
6
127
0.46
1.22
3.0
3.7
—
—
—
0
0
46
590
0.71
1.21
3.3
3.6
—
—
—
0
0
5
111
0.44
1.17
4.8
3.8
1.3
1.2
mmol/l
—
5
102
160
1485
1.46
1.16
14.8
13.0
39.8
40.6
%
0.50
115
1130
162
1510
1.47
1.12
4.6
4.4
5.8
5.9
mmol/l
0.86
147
1395
47
364
1.39
1.09
1.6
2.2
—
—
—
0
0
73
608
1.32
1.06
2.2
2.3
72.9
75.7
nmol/l
0.30
65
535
9
46
2.00
1.05
1.2
1.1
—
3.6
—
0
7
5
22
2.31
1.04
1.0
1.7
—
—
—
0
0
5
22
2.31
1.04
1.0
1.7
—
—
—
0
0
5
22
2.31
1.04
1.0
1.7
—
—
—
0
0
9
47
1.96
1.03
1.3
1.3
—
—
—
0
0
45
351
1.37
1.00
1.6
1.5
18.4
21.6
nmol/l
0.89
38
301
0
29
0.00
0.98
0.0
1.6
—
—
—
0
0
49
389
1.35
0.98
3.6
4.4
23.5
21.7
%
0.27
19
184
31
411
0.71
0.97
3.6
2.7
0.1
0.4
e6/l
1.64
24
301
169
1599
1.48
0.95
14.2
13.8
139.8
139.7
mmol/l
0.16
163
1559
43
336
1.36
0.95
2.0
2.0
2.2
3.2
mg/l
2.72
36
292
58
475
1.32
0.94
2.6
2.3
58.7
56.4
u/l
0.14
52
431
155
1451
1.35
0.88
4.9
4.5
1.8
1.9
mu/l
0.64
140
1329
92
808
1.27
0.86
3.9
6.1
9.8
11.2
umol/l
0.90
85
766
8
45
1.81
0.85
1.1
1.9
—
—
—
0
0
42
517
0.76
0.81
3.0
2.9
—
—
—
0
0
169
1609
1.42
0.81
14.4
13.9
4.0
4.0
mmol/l
0.16
163
1563
6
33
1.84
0.79
1.0
1.1
—
—
—
0
0
32
246
1.36
0.79
1.4
1.6
899.2
1156.8
nmol/l
1.13
27
188
8
133
0.58
0.76
2.6
2.1
11.6
14.6
nmol/l
—
8
128
178
1715
1.52
0.75
9.5
9.8
29.2
27.6
u/l
0.29
171
1670
5
25
2.03
0.73
1.2
1.2
—
—
—
0
0
167
1593
1.37
0.73
4.9
4.7
2.9
2.8
mmol/l
0.94
151
1482
128
1183
1.25
0.71
4.0
3.9
14.5
14.7
pmol/l
0.62
116
1074
75
658
1.23
0.68
2.7
2.6
123.1
113.2
ug/l
0.20
69
608
7
43
1.65
0.67
1.0
1.3
—
—
—
0
0
5
28
1.81
0.66
1.2
4.4
—
848.0
—
0
5
57
487
1.24
0.65
4.2
4.8
1.6
2.0
ug/l
1.04
50
436
6
103
0.57
0.64
1.0
1.3
—
—
—
0
0
8
51
1.59
0.61
1.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
10
65
1.57
0.56
6.6
7.0
24.8
24.6
mmol/l
—
10
59
6
39
1.56
0.53
2.0
1.9
0.0
0.0
g/l
—
6
39
6
39
1.56
0.53
2.0
1.9
0.0
0.0
g/l
—
6
39
152
1450
1.23
0.52
5.3
5.4
38.8
39.6
mmol/mol
0.63
141
1353
29
236
1.27
0.50
1.3
1.7
—
—
—
0
0
33
394
0.80
0.50
1.4
1.2
0.7
0.9
u/ml
—
7
113
7
45
1.58
0.49
1.3
1.6
—
—
—
0
0
21
165
1.31
0.47
1.3
1.6
—
—
—
0
0
163
1574
1.24
0.44
4.6
4.3
4.8
4.7
mmol/l
1.30
149
1474
8
57
1.42
0.42
2.1
1.8
—
—
—
0
0
20
159
1.29
0.42
1.4
1.6
—
—
—
0
0
162
1566
1.22
0.41
4.5
4.2
1.5
1.5
mmol/l
0.00
147
1456
0
15
0.00
0.41
0.0
1.8
—
0.2
—
0
10
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
5
35
1.44
0.39
1.2
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
158
1529
1.19
0.36
3.8
3.8
1.3
1.3
mmol/l
0.28
145
1408
6
42
1.44
0.36
2.0
1.9
0.0
0.1
g/l
—
6
42
48
429
1.16
0.34
2.0
2.0
165.5
204.7
u/l
0.29
43
407
31
268
1.19
0.33
1.3
1.3
66.8
24.4
iu/ml
—
7
95
7
54
1.31
0.31
1.1
1.7
—
—
—
0
0
7
57
1.24
0.29
1.4
2.1
—
—
—
0
0
5
71
0.70
0.26
1.6
2.6
43.2
40.1
u/l
—
5
63
9
72
1.26
0.26
4.1
3.5
2.9
1.3
mmol/l
—
9
53
9
76
1.19
0.25
4.1
3.5
5.2
5.0
kpa
—
9
70
6
82
0.72
0.24
7.2
4.4
24.4
25.0
mmol/l
—
6
82
15
179
0.82
0.24
4.3
7.2
—
—
—
0
0
10
125
0.79
0.23
2.0
1.8
—
—
—
0
0
5
41
1.23
0.22
1.6
1.4
—
—
—
0
0
5
41
1.23
0.22
1.6
1.4
—
—
—
0
0
5
41
1.23
0.22
1.6
1.4
—
—
—
0
0
8
102
0.78
0.21
2.1
1.7
—
—
—
0
0
42
385
1.12
0.21
2.2
3.0
630.4
1008.1
ng/l
1.16
33
323
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
3.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
24.1
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
13.2
—
0
12
0
12
0.00
0.21
0.0
2.1
—
100.2
—
0
12
0
13
0.00
0.21
0.0
3.8
—
86.8
—
0
13
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
2.0
2.2
—
7600.1
—
0
13
35
319
1.12
0.19
1.4
1.7
1.1
1.1
mg/l
0.01
26
242
6
52
1.16
0.19
1.0
1.5
—
—
—
0
0
15
128
1.19
0.19
2.6
3.7
5.9
5.7
kpa
0.18
15
123
9
79
1.15
0.15
1.2
1.3
—
—
—
0
0
9
79
1.15
0.15
1.0
1.6
—
—
—
0
0
7
89
0.78
0.15
1.0
1.0
—
—
—
0
0
111
1079
1.07
0.14
2.7
3.0
—
—
—
0
0
5
44
1.14
0.10
4.4
2.6
—
—
—
0
0
5
46
1.09
0.09
2.6
2.5
—
1.4
—
0
5
5
46
1.09
0.09
2.4
2.5
18.2
32.5
mg/l
—
5
38
5
46
1.09
0.09
2.4
2.5
29.4
207.8
mg/l
—
5
37
42
400
1.06
0.09
2.0
1.7
1.4
1.4
mmol/l
0.03
34
341
89
913
0.95
0.09
9.0
9.4
4.1
4.1
e9/l
0.02
81
798
6
56
1.07
0.09
1.3
1.3
—
—
—
0
0
25
234
1.08
0.08
1.7
2.3
—
—
—
0
0
16
147
1.10
0.07
3.7
2.0
397.4
372.0
nmol/l
0.24
16
136
12
108
1.12
0.07
1.0
1.2
43.0
108.6
iu/ml
—
5
43
31
326
0.94
0.07
1.8
1.5
—
—
—
0
0
7
80
0.87
0.07
1.4
1.5
—
—
—
0
0
22
233
0.94
0.06
3.1
2.7
0.6
2.2
e6/l
1.53
14
127
16
172
0.92
0.06
1.7
1.7
—
—
—
0
0
48
495
0.96
0.05
2.4
3.3
2.4
2.4
mmol/l
0.44
41
435
19
180
1.06
0.04
1.6
2.7
4.6
10.2
umol/l
1.56
14
159
11
102
1.08
0.03
1.7
1.5
—
—
—
0
0
150
1490
1.03
0.03
9.9
11.6
85.9
84.5
ml/min/173m2
0.28
115
1192
13
138
0.94
0.02
2.4
2.2
0.2
0.2
g/l
0.31
13
126
25
242
1.04
0.02
1.4
1.4
—
—
—
0
0
24
248
0.96
0.02
3.0
2.5
2.9
0.8
e6/l
0.47
16
141
160
1592
1.03
0.02
12.6
12.4
18.2
22.3
mg/l
1.08
124
1213
11
117
0.94
0.02
6.0
4.9
1.1
1.4
mmol/l
0.85
11
111
22
213
1.04
0.01
1.5
2.2
—
—
—
0
0
57
563
1.02
0.01
2.4
3.5
14.2
27.3
ng/l
4.08
32
369
10
99
1.01
0.00
2.7
3.7
4.5
4.8
pmol/l
—
10
86
25
254
0.98
0.00
1.3
1.3
1.2
6.2
u/ml
—
7
104
29
286
1.02
0.00
3.3
2.8
0.7
0.8
ug/l
0.11
19
187
88
879
1.00
0.00
4.8
4.1
6.8
6.6
mmol/l
0.26
76
816
19
187
1.02
0.00
2.5
2.2
22.2
25.5
%
0.45
12
163
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
4.8
—
213.0
—
0
8
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
67.0
—
0
6
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
0.00
0.0
1.0
—
137.9
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1662.4
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
7
72
0.97
0.00
3.0
1.7
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
0.00
0.0
2.4
—
126.1
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
24.0
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint H8_DISCON and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H8_DISCON.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H8_DISCON – Discontinuity and dislocation of ear ossicles
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data