osteitis deformans: A disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
178 |
4. Check minimum number of eventsNone |
178 |
5. Include endpointsNone |
178 |
6. Filter based on genotype QC (FinnGen only) |
171 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M86-M90
- Name in latin
- Osteitis deformans Paget
Similar endpoints
↥List of similar endpoints to
Paget disease
based on the number of shared cases.
Similar with more cases:
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1125 | 513 | 598 |
| Only index persons | 891 | 427 | 464 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 66.25 | 66.30 | 66.15 |
| Only index persons | 64.97 | 63.99 | 65.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 171 | 74 | 97 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 66.84 | 65.73 | 67.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 178
- Matched controls
- 1780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M88.9
ICD-10 Finland
Paget disease of bone, unspecified
+∞
128.1
107
*
M88.88
ICD-10 Finland
Paget disease of other bones, other
+∞
97.0
84
*
M88.0
ICD-10 Finland
Paget disease of skull
+∞
25.6
24
*
M88
ICD-10 Finland
Paget disease of bone [osteitis deformans]
+∞
16.9
16
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
23.8
16.5
23
11
ZX120
NOMESCO Finland
Intravenous
4.6
14.4
40
106
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.7
13.7
36
91
7310A
ICD-9 Finland
Osteitis deformans and osteopathies associated with other disorders classified elsewhere, Osteitis deformans without mention of bone tumour
+∞
12.6
12
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.1
12.4
92
458
NK6AN
NOMESCO Finland
Total body bone isotope imaging
9.1
9.3
19
23
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.9
9.3
30
88
NK6BN
NOMESCO Finland
Bone dynamic isotope examination
94.3
8.5
9
*
M79.0
ICD-10 Finland
Rheumatism, unspecified
9.0
7.5
15
18
72199
ICD-8 Finland
Osteitis deformans
+∞
7.3
7
*
NF1AA
NOMESCO Finland
Hip X-ray examination
3.3
7.2
30
104
N02AX02
ATC
tramadol; systemic, rectal
2.3
7.0
93
571
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
6.7
53
258
Q78.1
ICD-10 Finland
Polyostotic fibrous dysplasia
+∞
6.3
6
*
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
8.2
6.2
13
17
N03AX16
ATC
[U] pregabalin
2.4
6.0
51
255
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
38
20
23.89
49.76
1.8
1.1
—
—
—
0
0
50
109
5.99
23.20
2.7
4.1
71.38
88.47
ng/l
0.92
44
94
135
758
4.23
16.41
9.3
6.0
1.22
1.21
mmol/l
0.79
116
651
12
0
+∞
12.65
1.4
0.0
—
—
—
0
0
86
487
2.48
8.11
4.2
3.4
2.35
2.35
mmol/l
0.12
74
427
120
799
2.54
7.83
10.3
9.1
3.96
4.10
e9/l
0.28
103
697
23
67
3.79
7.12
2.6
1.3
—
—
—
0
0
100
636
2.31
6.91
6.4
4.3
35.26
34.71
g/l
0.42
91
587
18
49
3.97
6.09
2.6
4.0
77.74
196.69
mg/l
0.39
12
37
18
49
3.97
6.09
2.6
4.0
25.30
35.13
mg/l
0.39
12
38
134
998
2.39
5.95
4.5
3.7
15.24
14.96
pmol/l
0.74
126
879
24
88
3.00
5.18
1.6
1.9
—
—
—
0
0
133
1056
2.03
4.07
6.2
4.1
15.29
14.24
mm/h
0.25
121
957
14
43
3.45
4.00
2.4
2.1
1.90
1.70
mg/l
0.41
14
37
105
778
1.85
3.89
7.3
6.1
10.52
11.75
umol/l
0.82
98
728
82
569
1.82
3.71
4.1
3.2
—
—
—
0
0
90
646
1.80
3.61
2.9
2.5
—
—
—
0
0
103
773
1.79
3.52
22.0
16.8
1.38
1.36
inr
0.06
33
218
56
350
1.88
3.51
2.5
2.3
—
—
—
0
0
108
825
1.79
3.45
3.2
2.9
55.17
48.62
u/l
0.19
98
751
61
394
1.83
3.43
3.1
2.8
385.00
9490.02
umol/l
2.65
54
333
166
1470
2.92
3.43
25.5
18.1
139.74
139.68
mmol/l
0.11
166
1423
50
306
1.88
3.32
4.9
3.1
2.44
2.46
mmol/l
0.68
43
269
45
268
1.91
3.24
3.1
2.8
2.81
1.80
e6/l
0.29
28
152
153
1324
2.11
3.06
23.2
14.8
73.61
73.93
ml/min/173m2
0.06
137
1080
24
115
2.26
3.05
2.8
3.3
57.81
59.96
ml/min/173m2
0.07
13
52
164
1468
2.49
2.85
15.5
10.7
23.82
24.98
u/l
0.59
156
1401
64
444
1.69
2.72
3.7
3.3
0.44
0.31
e6/l
0.20
51
329
64
446
1.68
2.67
2.8
2.2
64.24
67.41
u/l
0.11
59
404
23
116
2.13
2.60
2.9
1.7
287.74
386.47
nmol/l
1.23
23
107
147
1277
1.87
2.58
6.3
4.5
1.85
2.01
mu/l
0.87
137
1131
166
1509
2.48
2.51
33.7
22.8
40.27
39.54
%
1.27
160
1404
166
1509
2.48
2.51
34.3
22.8
132.20
134.04
g/l
0.84
166
1477
91
703
1.60
2.47
4.9
3.8
0.00
0.00
estimate
-0.00
18
142
83
628
1.60
2.46
3.9
4.0
25.36
40.30
ng/l
1.55
66
494
155
1376
1.98
2.45
5.6
5.4
2.60
2.60
mmol/l
0.02
141
1247
156
1389
2.00
2.43
22.7
15.2
22.06
26.56
mg/l
1.11
135
1111
21
105
2.13
2.43
2.3
2.0
9.41
12.45
nmol/l
0.90
21
91
40
251
1.77
2.40
2.1
1.8
—
—
—
0
0
6
13
4.73
2.29
1.3
1.2
—
—
—
0
0
89
700
1.54
2.14
6.8
5.2
0.00
0.00
estimate
-0.00
18
133
18
91
2.09
2.03
1.4
1.4
—
—
—
0
0
9
32
2.91
2.03
1.4
1.1
—
—
—
0
0
42
280
1.65
2.02
3.5
2.7
1.41
0.91
e6/l
0.42
26
161
89
708
1.51
1.99
5.0
3.8
0.00
0.00
estimate
-0.00
14
124
152
1365
1.78
1.98
5.4
5.0
6.01
6.13
mmol/l
0.68
135
1238
6
16
3.84
1.95
6.5
3.5
—
—
—
0
0
12
54
2.31
1.78
1.5
1.6
—
—
—
0
0
68
523
1.49
1.74
3.1
2.9
1608.38
1419.26
ng/l
0.19
59
442
23
135
1.81
1.72
3.2
4.4
5.81
5.65
kpa
0.30
23
129
148
1334
1.65
1.72
5.1
4.8
4.52
4.45
mmol/l
0.28
134
1218
133
1175
1.52
1.63
28.2
18.5
16.04
15.29
%
0.61
133
1156
143
1284
1.58
1.62
4.6
4.3
1.39
1.25
mmol/l
1.42
126
1159
8
32
2.57
1.62
1.9
1.3
—
—
—
0
0
8
32
2.57
1.62
2.8
1.4
—
—
—
0
0
79
633
1.45
1.61
2.3
2.0
100.86
94.29
pmol/l
0.41
44
320
68
535
1.44
1.51
5.4
4.1
—
—
—
0
0
32
215
1.60
1.49
1.4
1.2
33.13
42.61
iu/ml
—
9
75
12
59
2.11
1.47
1.6
1.7
—
—
—
0
0
27
176
1.63
1.42
2.2
1.7
—
—
—
0
0
9
41
2.26
1.39
1.0
1.3
—
—
—
0
0
50
377
1.45
1.38
4.0
3.1
0.72
0.77
ug/l
0.22
40
268
10
47
2.19
1.36
1.5
1.1
—
—
—
0
0
145
1324
1.51
1.33
5.1
4.8
1.41
1.44
mmol/l
0.36
130
1198
65
518
1.40
1.32
4.9
4.6
21.61
21.30
%
0.06
41
272
24
155
1.63
1.31
4.0
3.8
—
—
—
0
0
5
18
2.83
1.29
6.4
2.7
5.62
12.17
nmol/l
—
5
18
79
653
1.38
1.28
5.9
5.3
2.31
2.73
ug/l
0.35
68
579
16
94
1.77
1.22
2.7
3.5
1.60
1.73
mmol/l
0.06
11
71
17
102
1.74
1.21
1.6
1.5
—
—
—
0
0
26
179
1.53
1.11
2.2
1.8
—
—
—
0
0
143
1318
1.43
1.10
7.0
6.4
40.29
41.16
mmol/mol
0.64
133
1218
35
260
1.43
1.04
1.4
1.2
0.63
1.10
u/ml
—
7
76
27
192
1.48
1.00
4.6
4.9
30.10
33.41
%
0.91
20
124
43
335
1.37
0.98
1.8
1.7
1190.20
1168.63
nmol/l
0.04
33
255
28
202
1.46
0.97
1.6
1.3
24.76
18.41
u/ml
0.11
12
75
6
28
2.18
0.92
1.3
1.2
—
—
—
0
0
13
79
1.70
0.91
4.1
8.2
24.60
24.66
mmol/l
0.02
13
79
76
656
1.28
0.84
2.8
2.4
—
—
—
0
0
61
513
1.29
0.82
4.7
3.9
5.11
10.26
mg/mmol
1.16
42
328
14
91
1.58
0.78
4.9
5.3
25.11
24.55
mmol/l
0.22
14
91
5
25
2.03
0.73
3.2
3.4
60.20
60.92
%
—
5
25
5
26
1.95
0.71
2.8
3.2
104.40
106.15
mmol/l
—
5
26
46
380
1.28
0.71
5.8
4.0
0.00
0.00
estimate
-0.00
16
125
41
338
1.28
0.64
2.0
1.8
379.64
457.01
pmol/l
1.68
36
281
8
49
1.66
0.63
2.9
2.9
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
6
35
1.74
0.58
1.8
1.2
—
—
—
0
0
10
69
1.48
0.45
1.9
1.7
0.19
4.97
ug/l
—
10
62
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
485.78
—
0
9
0
17
0.00
0.41
0.0
1.0
—
36.90
—
0
7
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
6
43
1.41
0.35
1.2
1.7
—
—
—
0
0
10
75
1.35
0.31
2.8
2.8
0.64
0.66
%
—
10
75
10
77
1.32
0.26
2.9
2.8
1.69
1.06
%
—
10
77
35
315
1.14
0.23
3.0
3.4
402.86
189.41
ng/l
0.38
29
261
0
11
0.00
0.21
0.0
1.1
—
8.83
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
40
372
1.10
0.16
1.6
1.7
1.69
1.31
mmol/l
0.82
32
304
11
128
0.85
0.14
1.3
1.3
—
—
—
0
0
20
180
1.13
0.14
8.2
8.0
—
—
—
0
0
11
95
1.17
0.12
4.7
8.1
95.80
94.69
%
1.04
11
95
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
15
161
0.93
0.05
1.1
1.3
—
—
—
0
0
24
244
0.98
0.00
2.0
1.9
29.02
29.44
s
0.18
24
237
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
66
0.91
-0.00
3.2
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
17.46
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
5
57
0.87
-0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_PAGET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PAGET | 1.012 [0.76, 1.35] | 0.938 |
| Birth year | 0.999 [0.99, 1.01] | 0.783 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 317 females with M13_PAGET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_PAGET | 1.119 [0.88, 1.43] | 0.362 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 132 out of 382 males with M13_PAGET died.
Mortality risk
Mortality risk for people of age
years, who have M13_PAGET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.261% |
| 5 | 0.632% | 1.405% |
| 10 | 1.7% | 3.576% |
| 15 | 3.327% | 6.476% |
| 20 | 6.058% | 11.352% |
Relationships between endpoints
↥Index endpoint: M13_PAGET – Paget disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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