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Malignant neoplasm of nasal cavity and sinuses

C3_NASAL_CAVITY_SINUSES

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 C30, C31
  • Cause of death: ICD-9 160
  • Cause of death: ICD-8 160
  • Cancer registry: Topography ICD-O-3 C3[01]
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

2 out of 7 registries used, show all original rules.

224

4. Check minimum number of events

None

224

5. Include endpoints

None

224

6. Filter based on genotype QC (FinnGen only)

224

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9

Similar endpoints

List of similar endpoints to Malignant neoplasm of nasal cavity and sinuses based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 224 89 135
Unadjusted period prevalence (%) 0.05 0.03 0.06
Median age at first event (years) 65.47 64.20 66.31

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
207
Matched controls
2069
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C30.0
ICD-10 Finland
Malignant neoplasm: Nasal cavity
2219.7
124.4
108
*
DHA10
NOMESCO Finland
Biopsy of cavity of nose
251.1
69.9
68
*
D14.0
ICD-10 Finland
Benign neoplasm: Middle ear, nasal cavity and accessory sinuses
167.8
59.5
60
5
UDH02
NOMESCO Finland
Rhinopharyngoscopy
21.0
55.5
87
69
8070/3-C30.0
ICD-O-3
Squamous cell carcinoma, NOS, of nasal cavity
+∞
44.4
41
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
27.0
42.3
59
30
DHB10
NOMESCO Finland
Excision of lesion of internal nose
487.5
41.7
40
*
UDM02
NOMESCO Finland
Sinoscopy
42.5
35.8
44
13
DM1DG
NOMESCO Finland
Paranasal sinuses and face area very extensive MRI examination with high intensity magnet
+∞
35.4
33
*
130
Kela drug reimbursment
Malignant tumour
11.6
35.0
70
87
C31.0
ICD-10 Finland
Malignant neoplasm: Maxillary sinus
+∞
34.3
32
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
97.7
30.8
33
*
WF002
NOMESCO Finland
Radical radiotherapy
11.5
28.1
55
63
DM1BD
NOMESCO Finland
Extensive CT of paranasal sinuses and face area
309.0
27.4
27
*
YA1VG
NOMESCO Finland
MRI examination of head and neck with high intesity magnet for dose design of radiotherapy
+∞
25.5
24
*
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
80.4
25.5
28
*
DNB30
NOMESCO Finland
Excision of lesion of ethmoidal sinus
+∞
24.5
23
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.8
24.3
113
412
8720/3-C30.0
ICD-O-3
Malignant melanoma, NOS, of nasal cavity
+∞
23.4
22
*
D38.51
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of other accessory sinus
+∞
23.4
22
*
A03FA01
ATC
metoclopramide; systemic, rectal
5.3
22.7
84
237
R04.0
ICD-10 Finland
Epistaxis
8.3
22.5
53
82
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
35.7
22.1
28
9
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
12.1
21.6
40
40
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
11.8
21.3
40
41
C31.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of accessory sinuses
+∞
21.2
20
*
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
29.2
21.1
28
11
H02AB02
ATC
dexamethasone; systemic
7.2
20.5
53
94
DJB10
NOMESCO Finland
Excision of septum of nose
+∞
20.1
19
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
14.9
19.7
33
26
XX3DW
NOMESCO Finland
Time consuming IT work
6.0
19.2
58
126
DMA00
NOMESCO Finland
Biopsy of maxillary antrum
+∞
19.0
18
*
8070/3-C31.0
ICD-O-3
Squamous cell carcinoma, NOS, of maxillary sinus
+∞
19.0
18
*
YA1CD
NOMESCO Finland
Very extensive CT examination of head and neck for dose design of radiotherapy
+∞
19.0
18
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
15.6
19.0
31
23
A04AA02
ATC
granisetron; systemic, transdermal
9.9
18.5
38
46
DPA30
NOMESCO Finland
Sphenotomy
58.1
18.3
21
*
D38.58
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of other respiratory organ
+∞
18.0
17
*
DHB40
NOMESCO Finland
Conchotomy
196.1
17.8
18
*
A04AA01
ATC
ondansetron; systemic, rectal
7.9
16.9
40
61
AAE99
NOMESCO Finland
Other operation by cranial base approach
+∞
16.9
16
*
DM1CG
NOMESCO Finland
Paranasal sinuses and face area extensive MRI examination with high intensity magnet
184.2
16.8
17
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
8.1
16.1
37
54
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
8.7
16.0
35
47
N02AA05
ATC
oxycodone; systemic
4.5
15.9
64
187
EEB00
NOMESCO Finland
Partial excision of maxilla
172.5
15.7
16
*
SAA03
NOMESCO Finland
Extended examination of mouth
3.4
15.0
104
477
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
17.1
14.8
23
15
ZX090
NOMESCO Finland
Other technic of radiotherapy
12.8
14.8
26
23
DPC35
NOMESCO Finland
Extensive endoscopic excision of lesion or neoplasm extending to more than one paranasal sinus
+∞
14.8
14
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
7.0
14.6
37
62
L03AA02
ATC
filgrastim; parenteral
14.1
14.3
24
19
A07AA02
ATC
nystatin; oral
7.2
14.1
35
57
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
15.1
14.1
23
17
EP1AE
NOMESCO Finland
Neck ultrasound examination
6.9
13.8
35
59
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
80.6
13.8
15
*
9522/3-C30.0
ICD-O-3
Olfactory neuroblastoma of nasal cavity
+∞
13.7
13
*
DMB30
NOMESCO Finland
Transmaxillary excision of lesion of maxillary antrum
+∞
13.7
13
*
C72.2
ICD-10 Finland
Malignant neoplasm: Olfactory nerve
+∞
13.7
13
*
ZXC95
NOMESCO Finland
Use of surgical navigator
28.0
13.6
18
7
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
5.6
13.5
41
87
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
74.6
12.8
14
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
3.0
12.5
103
514
ZX070
NOMESCO Finland
Intensity modified radiotherapy
12.2
12.4
22
20
UDQ12
NOMESCO Finland
Flexible laryngoscopy
6.1
12.0
33
62
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
24.6
11.8
16
7
EEB10
NOMESCO Finland
Maxillectomy
+∞
11.6
11
*
C31.9
ICD-10 Finland
Malignant neoplasm: Accessory sinus, unspecified
+∞
11.6
11
*
9680/3-C30.0
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of nasal cavity
+∞
11.6
11
*
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
37.3
11.4
14
*
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
21.5
11.3
16
8
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.7
11.1
32
64
JDB10
NOMESCO Finland
Percutaneous gastrostomy
23.0
10.8
15
7
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
10.9
10.8
20
20
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
63.3
10.7
12
*
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
63.3
10.7
12
*
CCD60
NOMESCO Finland
Transnasal dacryocystorhinostomy
63.3
10.7
12
*
D38.50
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of maxillary sinus
+∞
10.5
10
*
R4190
NOMESCO Finland
Nutritional therapy
12.2
10.3
18
16
J33.0
ICD-10 Finland
Polyp of nasal cavity
10.9
10.3
19
19
Z51.5
ICD-10 Finland
Palliative care
5.6
10.0
29
58
WX402
NOMESCO Finland
General anaesthesia
3.3
9.8
53
193
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
18.6
9.5
14
8
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
31.7
9.5
12
*
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
31.7
9.5
12
*
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
104.6
9.5
10
*
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
23.0
9.5
13
6
DPB00
NOMESCO Finland
Partial excision of frontal sinus
+∞
9.4
9
*
ZZQ20
NOMESCO Finland
Free microvascular graft of skin, muscle and bone
+∞
9.4
9
*
C31.1
ICD-10 Finland
Malignant neoplasm: Ethmoidal sinus
+∞
9.4
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
9.4
76
358
ZZF00
NOMESCO Finland
Graft of adipose tissue
38.5
9.1
11
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
25.3
9.0
12
5
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
7.8
9.0
20
28
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.5
8.9
26
53
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
4.9
8.9
29
67
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.8
8.9
39
120
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
8.7
107
632
A04AD12
ATC
aprepitant; systemic
21.1
8.6
12
6
J33.9
ICD-10 Finland
Nasal polyp, unspecified
28.9
8.6
11
*
AA1BD
NOMESCO Finland
Extensive CT of head and brain
8.5
8.6
18
23
C43.39
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face other or unspecified histology
93.7
8.5
9
*
AAE05
NOMESCO Finland
Nasoendoscopic closure of cerebrospinal fluid fistula
+∞
8.4
8
*
DLW99
NOMESCO Finland
Other plastic operations on nose
+∞
8.4
8
*
DKW40
NOMESCO Finland
Ligature of artery of internal nose
+∞
8.4
8
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
5.7
8.3
23
44
SBB10
NOMESCO Finland
Teeth copy
5.2
8.3
25
53
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
7.1
8.1
19
29
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.0
7.9
49
194
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
6.0
7.9
21
38
ZZC00
NOMESCO Finland
Graft of fascia
46.8
7.8
9
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.4
7.7
38
128
ZX095
NOMESCO Finland
Combined chemoradiotherapy
19.3
7.7
11
6
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
26.1
7.6
10
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.5
7.6
36
118
AAK40
NOMESCO Finland
Closure of cerebrospinal fluid fistula
82.9
7.5
8
*
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
82.9
7.5
8
*
GD6AD
NOMESCO Finland
CT of chest and neck
82.9
7.5
8
*
ZZR50
NOMESCO Finland
Mucoperiosteal flap
+∞
7.3
7
*
GBB00
NOMESCO Finland
Tracheostomy
16.5
7.3
11
7
R01AD09
ATC
mometasone; nasal
2.3
7.2
96
572
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
9.3
7.2
14
16
EBA15
NOMESCO Finland
Extraction of large number of teeth
6.3
7.1
18
31
ZXA05
NOMESCO Finland
Left side
2.4
7.0
67
340
ZXE40
NOMESCO Finland
More than seven and less than nine hours
7.6
6.8
15
21
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
17.4
6.8
10
6
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
6.7
47
198
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
6.6
6.6
16
26
WF049
NOMESCO Finland
Radiotherapy of metastasis
6.6
6.6
16
26
WW500
NOMESCO Finland
Blood transfusion
4.9
6.5
20
44
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
14.9
6.5
10
7
DHB01
NOMESCO Finland
Partial excision of external nose
72.0
6.5
7
*
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
6.3
6.4
16
27
WX110
NOMESCO Finland
Local anesthesy
2.2
6.4
138
995
H16.0
ICD-10 Finland
Corneal ulcer
5.0
6.3
19
41
CAD00
NOMESCO Finland
Exenteration of orbit with use of graft or flap
+∞
6.3
6
*
DLD20
NOMESCO Finland
Rhinoplasty
+∞
6.3
6
*
ZXB10
NOMESCO Finland
Medial
+∞
6.3
6
*
L01AX03
ATC
temozolomide; systemic
+∞
6.3
6
*
8200/3-C30.0
ICD-O-3
Adenoid cystic carcinoma of nasal cavity
+∞
6.3
6
*
8020/3-C30.0
ICD-O-3
Carcinoma, undifferentiated, NOS, of nasal cavity
+∞
6.3
6
*
R09
ICPC
Sinus symptom/complaint
4.5
6.2
21
51
J34.8
ICD-10 Finland
Other specified disorders of nose and nasal sinuses
13.1
6.1
10
8
R08
ICPC
Nose symptom/complaint other
7.6
6.0
13
18
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
7.6
6.0
13
18

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_NASAL_CAVITY_SINUSES – Malignant neoplasm of nasal cavity and sinuses

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).