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This is a non-core endpoint: only basic statistics are computed.

Benign neoplasm: Bone and articular cartilage, unspecified

CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D16.90&, D16.91&
  • Hospital discharge: ICD-9 2139
  • Hospital discharge: ICD-8 2130[8-9]
  • Cause of death: ICD-10 D16.90&, D16.91&
  • Cause of death: ICD-9 2139
  • Cause of death: ICD-8 2130[8-9]

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 275 158 117
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 38.62 38.37 38.96

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
245
Matched controls
2450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D16.90
ICD-10 Finland
Bone and articular cartilage, unspecified
+∞
168.9
142
*
21309
ICD-8 Finland
Benign neoplasm of bone and cartilage, Unspecified
+∞
45.2
42
*
21308
ICD-8 Finland
Benign neoplasm of bone and cartilage, Loco alio sive multiplici
+∞
34.2
32
*
2139X
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Bone and articular cartilage, site unspecified
+∞
20.1
19
*
130
Kela drug reimbursment
Malignant tumour
+∞
13.7
13
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
19.6
13.6
20
11
AAP10
NOMESCO Finland
Extirpation of a skull lesion
+∞
12.6
12
*
9102
FHL
Trepanation or removal of the local bone process
29.5
10.8
14
5
D16.49
ICD-10 Finland
Bones of skull and face
+∞
10.5
10
*
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
21.1
9.9
14
7
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
9.4
9
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
9.4
9
*
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
+∞
9.4
9
*
D16.1
ICD-10 Finland
Benign neoplasm: Short bones of upper limb
+∞
9.4
9
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
9.4
9
*
H02AB02
ATC
dexamethasone; systemic
13.4
8.5
14
11
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
8.4
8
*
D16.9
ICD-10 Finland
Benign neoplasm: Bone and articular cartilage, unspecified
+∞
8.4
8
*
115
Kela drug reimbursment
Breast cancer
+∞
8.4
8
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
8.4
8
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
8.4
8
*
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
19.1
7.7
11
6
WF002
NOMESCO Finland
Radical radiotherapy
+∞
7.3
7
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
7.3
7
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
+∞
7.3
7
*
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
+∞
7.3
7
*
D16.91
ICD-10 Finland
Benign tumor in unspecified localization in bone with urpsrung in teeth
+∞
7.3
7
*
JN4BD
NOMESCO Finland
Extensive body CT
4.9
6.4
20
44
L02BG04
ATC
letrozole; oral
18.6
6.3
9
5
L01BC06
ATC
capecitabine; oral
+∞
6.3
6
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
51
4.83
9.97
1.3
1.2
—
—
—
0
0
109
701
1.92
6.20
2.1
1.6
—
—
—
0
0
129
901
1.81
5.49
4.7
5.8
1.2
1.2
mmol/l
0.04
112
778
116
812
1.74
4.71
4.0
5.3
1.2
1.2
mmol/l
0.01
100
729
153
1175
1.68
4.29
3.6
4.3
6.4
6.6
mmol/l
0.64
137
1082
193
1578
1.75
4.28
7.7
5.0
74.7
74.7
u/l
0.00
185
1454
65
395
1.85
4.19
1.4
1.3
5.4
8.5
u/ml
0.27
26
153
80
522
1.75
4.06
2.2
2.2
320.1
4318.3
umol/l
1.59
72
464
67
417
1.80
3.98
1.5
1.3
55.7
27.9
iu/ml
0.28
26
131
7
8
8.94
3.79
1.1
1.4
—
—
—
0
0
83
577
1.63
3.24
2.2
1.9
—
—
—
0
0
126
980
1.53
2.98
6.3
3.6
12.8
11.2
umol/l
0.33
121
910
85
615
1.55
2.76
3.2
2.0
2.4
2.3
mmol/l
0.22
75
528
6
10
6.10
2.71
1.8
1.3
0.8
1.0
g/l
—
6
10
43
264
1.75
2.65
2.0
2.1
—
—
—
0
0
39
237
1.75
2.49
1.5
1.7
—
—
—
0
0
242
2216
1.77
2.46
13.5
10.7
20.0
20.4
mg/l
0.09
201
1650
96
730
1.48
2.42
5.7
7.5
1.2
1.2
inr
0.24
23
217
5
8
6.34
2.38
1.0
1.0
—
—
—
0
0
102
788
1.47
2.37
4.4
3.6
36.7
36.4
g/l
0.17
97
734
139
1146
1.43
2.26
9.5
6.5
4.0
4.1
e9/l
0.22
121
995
72
524
1.51
2.23
3.3
2.9
7.4
7.4
ph
—
8
82
244
2254
1.73
2.21
13.8
12.5
3.9
4.0
mmol/l
0.37
238
2184
189
1654
1.46
2.18
4.4
3.7
9.6
10.2
mm/h
0.25
176
1532
48
321
1.60
2.15
1.5
1.3
724.0
518.5
titre
—
10
78
243
2249
1.69
2.09
13.8
12.4
139.6
139.7
mmol/l
0.45
236
2183
5
10
5.07
2.08
1.0
1.0
—
—
—
0
0
16
77
2.14
2.01
1.5
1.1
—
—
—
0
0
65
474
1.49
1.98
7.2
4.9
—
—
—
0
0
29
174
1.75
1.95
1.6
1.1
—
—
—
0
0
23
131
1.82
1.84
3.6
4.3
0.5
0.8
%
—
6
29
33
211
1.64
1.78
1.9
4.9
1.1
1.0
mmol/l
0.97
33
190
83
647
1.41
1.77
1.7
2.1
296.9
176.1
u/l
0.68
75
603
21
118
1.84
1.76
2.1
1.3
—
—
—
0
0
171
1500
1.37
1.74
3.4
3.4
—
—
—
0
0
191
1706
1.39
1.74
4.0
3.8
14.4
14.6
pmol/l
0.39
174
1569
19
105
1.87
1.67
1.1
1.1
—
—
—
0
0
55
404
1.45
1.61
2.0
2.1
5.1
6.0
e6/l
0.17
48
346
98
796
1.36
1.61
2.8
3.2
81.1
42.8
ng/l
0.30
63
497
25
155
1.67
1.53
1.2
1.2
—
—
—
0
0
126
1071
1.33
1.51
6.1
5.4
0.2
0.2
e9/l
0.08
112
944
118
994
1.33
1.50
6.3
5.0
56.7
56.6
%
0.03
110
926
9
37
2.48
1.49
3.3
1.8
52.3
13.2
u/ml
—
9
31
10
45
2.27
1.48
3.1
2.5
—
—
—
0
0
68
528
1.38
1.47
2.7
2.6
0.1
0.4
e6/l
2.04
57
383
20
119
1.73
1.42
4.0
4.6
0.0
0.0
%
—
5
23
7
29
2.45
1.40
1.9
1.4
—
—
—
0
0
222
2061
1.40
1.40
4.8
4.5
1.7
2.4
mu/l
0.73
207
1915
40
286
1.47
1.35
1.2
1.2
—
—
—
0
0
117
997
1.30
1.34
6.5
5.2
28.6
29.1
%
0.19
110
925
124
1065
1.30
1.34
6.3
5.1
2.0
1.9
e9/l
0.14
112
940
165
1472
1.30
1.33
4.4
3.7
—
—
—
0
0
57
437
1.38
1.32
4.0
4.0
—
—
—
0
0
27
178
1.57
1.32
2.0
3.5
—
—
—
0
0
6
24
2.53
1.31
1.3
1.1
—
—
—
0
0
114
971
1.30
1.30
6.3
5.1
2.9
3.0
%
0.11
106
894
114
972
1.30
1.29
6.8
5.4
8.5
8.3
%
0.20
105
907
82
669
1.32
1.28
5.6
5.0
—
—
—
0
0
76
615
1.33
1.25
3.3
4.0
3.6
7.3
mg/mmol
1.15
49
397
62
489
1.35
1.21
1.4
1.6
0.7
1.0
mg/l
1.30
48
367
67
535
1.33
1.21
2.6
2.7
—
—
—
0
0
66
527
1.33
1.19
2.7
2.5
—
—
—
0
0
109
933
1.28
1.18
6.2
5.1
0.7
0.7
%
0.37
102
864
46
351
1.37
1.11
2.7
2.0
2.4
2.4
mmol/l
0.88
40
295
25
171
1.51
1.07
1.9
2.8
—
—
—
0
0
119
1043
1.25
1.03
6.3
5.1
0.0
0.0
e9/l
0.89
104
906
10
53
1.92
1.02
1.9
1.5
—
—
—
0
0
67
548
1.29
1.02
3.4
3.3
0.0
0.0
estimate
0.80
21
185
118
1035
1.25
1.01
6.3
5.1
0.6
0.6
e9/l
0.10
102
898
24
165
1.50
1.01
1.9
2.5
1.8
2.2
mmol/l
0.26
18
125
70
577
1.29
1.00
2.8
3.3
1002.9
274.8
mg/l
0.33
46
376
19
124
1.57
0.99
4.0
4.4
0.0
0.1
%
—
5
24
0
29
0.00
0.98
0.0
1.3
—
6.3
—
0
18
0
29
0.00
0.98
0.0
1.3
—
—
—
0
0
0
29
0.00
0.98
0.0
1.3
—
2.8
—
0
18
0
29
0.00
0.98
0.0
1.3
—
0.3
—
0
18
83
702
1.26
0.97
3.2
3.2
138.9
98.4
e6/l
0.14
66
483
18
117
1.58
0.96
1.2
1.2
—
—
—
0
0
246
2359
1.41
0.95
12.1
10.1
—
—
—
0
0
10
55
1.85
0.93
2.3
2.4
0.2
0.2
g/l
—
5
14
20
287
0.67
0.92
1.2
1.4
—
—
—
0
0
6
28
2.17
0.92
1.0
1.3
—
—
—
0
0
59
485
1.28
0.87
4.8
4.1
—
—
—
0
0
62
513
1.27
0.86
1.4
1.3
5.1
1.4
u/ml
0.43
20
139
70
588
1.26
0.86
2.7
2.7
42.0
53.8
e6/l
0.15
59
444
6
31
1.96
0.85
1.2
1.0
—
—
—
0
0
22
155
1.46
0.84
1.4
1.4
—
—
—
0
0
11
66
1.69
0.80
1.1
1.2
—
—
—
0
0
6
33
1.84
0.79
1.3
1.2
—
—
—
0
0
5
24
2.10
0.75
1.2
2.8
—
—
—
0
0
7
38
1.86
0.74
1.4
1.3
398.0
11.6
u/l
—
7
33
43
350
1.27
0.69
1.4
1.7
1106.8
1183.1
nmol/l
0.26
34
272
16
111
1.47
0.67
2.8
2.2
—
—
—
0
0
5
29
1.74
0.64
2.2
1.2
—
—
—
0
0
34
272
1.29
0.63
2.1
2.2
65.8
92.6
ug/g
0.72
29
217
13
88
1.50
0.61
4.7
14.9
—
—
—
0
0
32
256
1.28
0.60
1.4
1.5
—
—
—
0
0
8
53
1.52
0.59
1.9
1.5
—
—
—
0
0
6
37
1.64
0.56
1.2
1.1
—
—
—
0
0
6
39
1.55
0.53
1.0
1.3
—
—
—
0
0
21
268
0.77
0.52
1.4
1.8
—
—
—
0
0
257
2517
1.32
0.49
20.4
15.8
4.6
4.6
e12/l
0.03
252
2455
113
1041
1.15
0.49
3.3
3.1
0.0
0.0
estimate
0.00
22
182
19
146
1.32
0.48
3.2
2.9
—
—
—
0
0
52
453
1.18
0.46
1.3
1.2
2.3
2.5
g/l
0.51
34
266
12
86
1.41
0.45
2.7
2.7
—
—
—
0
0
72
648
1.15
0.43
2.8
3.1
8.1
8.0
mmol/l
0.05
61
551
101
932
1.13
0.42
8.4
7.1
0.0
0.0
e9/l
0.50
84
756
5
33
1.52
0.41
1.0
1.0
—
6.2
—
0
7
0
16
0.00
0.41
0.0
2.6
—
560.3
—
0
10
11
149
0.73
0.41
6.9
6.8
1.1
1.3
mmol/l
1.34
11
142
14
106
1.34
0.40
1.2
1.1
—
—
—
0
0
63
566
1.15
0.39
3.5
3.4
—
—
—
0
0
5
36
1.40
0.38
1.0
1.4
—
—
—
0
0
5
36
1.40
0.38
2.0
1.7
—
—
—
0
0
244
2390
1.19
0.35
11.1
8.0
26.9
26.0
u/l
0.44
235
2308
11
144
0.75
0.34
1.5
1.6
—
—
—
0
0
6
46
1.31
0.33
4.2
3.3
—
—
—
0
0
53
477
1.14
0.33
3.9
3.4
1.0
1.0
kg/l
—
7
67
113
1065
1.10
0.32
3.3
3.1
0.0
0.0
estimate
0.00
23
179
224
2186
1.13
0.31
4.0
4.2
5.7
5.9
mmol/l
1.11
206
2011
90
840
1.11
0.30
2.0
1.9
98.3
96.5
pmol/l
0.11
52
432
111
1048
1.10
0.30
4.5
4.3
0.0
0.0
estimate
0.50
23
183
22
186
1.20
0.29
1.3
1.3
—
—
—
0
0
14
112
1.26
0.29
3.4
8.2
—
—
—
0
0
67
618
1.11
0.28
2.3
2.7
—
—
—
0
0
43
387
1.13
0.27
2.6
3.8
437.5
271.6
ng/l
0.20
31
286
203
2081
0.91
0.27
5.1
5.3
38.7
39.5
mmol/mol
0.59
192
1958
8
67
1.20
0.26
1.0
1.1
—
—
—
0
0
86
808
1.09
0.25
3.4
3.0
—
—
—
0
0
19
223
0.84
0.25
1.4
1.4
—
—
—
0
0
23
199
1.17
0.24
1.3
1.2
—
—
—
0
0
29
258
1.14
0.22
1.1
1.4
—
—
—
0
0
61
568
1.10
0.22
1.8
1.6
1.3
1.4
mmol/l
0.45
53
487
8
101
0.79
0.21
1.8
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
1782.9
—
0
12
0
13
0.00
0.21
0.0
2.6
—
53.9
—
0
8
0
13
0.00
0.21
0.0
2.8
—
—
—
0
0
48
443
1.10
0.21
1.8
1.9
—
—
—
0
0
192
1875
1.08
0.20
17.3
12.9
13.8
13.5
%
0.68
185
1836
50
463
1.10
0.20
4.2
3.1
—
—
—
0
0
214
2099
1.09
0.20
15.6
11.7
39.8
40.7
%
0.93
169
1612
7
59
1.19
0.18
1.4
1.3
—
—
—
0
0
16
184
0.86
0.17
1.2
1.4
—
—
—
0
0
214
2174
0.93
0.16
3.6
3.8
1.2
1.3
mmol/l
1.77
196
2024
62
654
0.93
0.15
5.1
3.3
1.7
1.7
ug/l
0.03
57
580
28
255
1.11
0.15
1.3
1.4
—
—
—
0
0
21
188
1.13
0.15
5.6
9.8
1.6
1.6
mmol/l
0.02
16
143
9
83
1.09
0.15
1.3
1.7
—
—
—
0
0
39
366
1.08
0.12
3.1
2.4
1.3
0.7
ug/l
0.40
25
213
222
2246
0.94
0.12
4.0
4.2
1.5
1.5
mmol/l
0.56
203
2104
13
114
1.15
0.12
2.5
2.9
—
7.4
—
0
8
18
199
0.90
0.12
1.9
2.2
1.4
1.6
%
1.45
18
182
14
124
1.14
0.11
1.1
1.1
—
—
—
0
0
16
144
1.12
0.10
1.4
1.4
—
—
—
0
0
11
96
1.15
0.10
1.2
1.3
—
1.6
—
0
6
13
145
0.89
0.09
2.2
2.3
49.9
66.3
e9/l
—
7
114
88
904
0.96
0.09
2.3
2.7
—
—
—
0
0
7
64
1.10
0.08
3.6
3.2
—
—
—
0
0
8
75
1.07
0.07
2.5
1.8
—
—
—
0
0
9
85
1.06
0.07
1.7
1.3
—
—
—
0
0
10
89
1.13
0.07
3.6
2.7
—
—
—
0
0
14
128
1.10
0.07
5.9
7.9
—
—
—
0
0
9
101
0.89
0.06
1.7
1.4
—
—
—
0
0
9
101
0.89
0.06
1.7
1.4
—
—
—
0
0
9
100
0.90
0.06
1.7
1.4
—
—
—
0
0
16
172
0.93
0.06
1.7
2.8
—
—
—
0
0
37
357
1.04
0.05
1.6
1.6
—
—
—
0
0
25
259
0.96
0.02
1.6
1.7
—
—
—
0
0
13
137
0.95
0.01
2.5
2.3
—
—
—
0
0
47
478
0.98
0.01
1.5
1.5
18.5
21.1
nmol/l
0.74
39
422
225
2257
0.98
0.01
4.2
4.2
4.7
4.7
mmol/l
0.20
203
2120
229
2291
1.00
0.00
4.7
4.7
2.7
2.8
mmol/l
0.33
212
2140
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
0.2
—
0
6
5
49
1.02
0.00
1.6
1.6
1.9
1.9
ug/l
—
5
43
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.9
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
58
580
1.00
0.00
1.4
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
20.5
—
0
7
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
7
79
0.88
0.00
9.4
11.4
25.1
25.0
mmol/l
—
7
72
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
2135.7
—
0
7
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
9
96
0.94
0.00
1.7
1.4
—
—
—
0
0
5
54
0.92
0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
8.6
—
26.0
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
10.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
5.9
—
0
7
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
8
79
1.01
0.00
2.1
10.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_BENIGN_BONE_CARTILAGE_NOS_EXALLC – Benign neoplasm: Bone and articular cartilage, unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).