Benign neoplasm: Bone and articular cartilage, unspecified

CD2_BENIGN_BONE_CARTILAGE_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D16.90&, D16.91&
  • Hospital discharge: ICD-9 2139
  • Hospital discharge: ICD-8 2130[8-9]
  • Cause of death: ICD-10 D16.90&, D16.91&
  • Cause of death: ICD-9 2139
  • Cause of death: ICD-8 2130[8-9]

2 out of 7 registries used, show all original rules.

275

4. Check minimum number of events

None

275

5. Include endpoints

None

275

6. Filter based on genotype QC (FinnGen only)

275

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2211 1137 1059
Only index persons 1934 1023 911
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 35.83 38.19 33.13
Only index persons 33.83 37.05 30.22

-FinnGen-

Key figures

All Female Male
Number of individuals 275 158 117
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 38.62 38.37 38.96

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
245
Matched controls
2447
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D16.90
ICD-10 Finland
Bone and articular cartilage, unspecified
+∞
169.0
142
*
21309
ICD-8 Finland
Benign neoplasm of bone and cartilage, Unspecified
+∞
45.2
42
*
21308
ICD-8 Finland
Benign neoplasm of bone and cartilage, Loco alio sive multiplici
+∞
34.2
32
*
2139X
ICD-9 Finland
Benign neoplasm of bone and articular cartilage, Bone and articular cartilage, site unspecified
+∞
20.1
19
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
18.0
13.2
20
12
AAP10
NOMESCO Finland
Extirpation of a skull lesion
+∞
12.6
12
*
D16.49
ICD-10 Finland
Bones of skull and face
+∞
10.5
10
*
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
57.3
9.7
11
*
9102
FHL
Trepanation or removal of the local bone process
18.4
9.5
14
8
D16.9
ICD-10 Finland
Benign neoplasm: Bone and articular cartilage, unspecified
+∞
8.4
8
*
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
12.3
8.2
14
12
D16.1
ICD-10 Finland
Benign neoplasm: Short bones of upper limb
46.5
7.8
9
*
D16.91
ICD-10 Finland
Benign tumor in unspecified localization in bone with urpsrung in teeth
+∞
7.3
7
*
D16.0
ICD-10 Finland
Benign neoplasm: Scapula and long bones of upper limb
31.0
7.2
9
*
NFR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of hip or thigh
71.6
6.5
7
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
65
382
1.92
4.68
1.4
1.3
5.4
8.1
u/ml
0.23
26
152
67
402
1.88
4.52
1.5
1.3
55.7
24.6
iu/ml
0.32
26
130
129
986
1.58
3.43
4.7
7.1
1.2
1.2
mmol/l
0.12
112
828
80
558
1.61
3.07
2.2
2.5
320.1
4367.3
umol/l
1.81
72
488
153
1236
1.54
3.06
3.6
5.0
6.4
6.6
mmol/l
0.59
137
1145
116
897
1.51
2.77
4.0
6.1
1.2
1.2
mmol/l
0.06
100
820
25
132
1.98
2.45
1.2
1.2
—
—
—
0
0
193
1694
1.47
2.21
7.7
7.1
74.7
78.1
u/l
0.68
185
1583
6
14
4.36
2.16
1.8
1.5
0.8
1.0
g/l
—
6
14
48
325
1.58
2.05
1.5
1.3
724.0
525.6
titre
—
10
71
189
1663
1.44
2.05
4.4
3.8
9.6
10.5
mm/h
0.42
176
1529
39
253
1.63
1.98
1.5
1.6
—
—
—
0
0
244
2273
1.65
1.89
13.8
14.6
3.9
4.0
mmol/l
0.52
238
2207
83
643
1.42
1.84
1.7
2.0
296.9
230.8
u/l
0.29
75
605
243
2268
1.61
1.78
13.8
14.6
139.6
139.7
mmol/l
0.25
236
2205
242
2257
1.60
1.77
13.5
13.0
20.0
21.5
mg/l
0.35
201
1739
191
1708
1.39
1.71
4.0
3.9
14.4
14.6
pmol/l
0.61
174
1559
109
894
1.36
1.70
2.1
1.9
—
—
—
0
0
43
297
1.53
1.69
2.0
2.2
—
—
—
0
0
19
106
1.85
1.63
1.1
1.1
—
—
—
0
0
76
595
1.38
1.56
3.3
4.1
3.6
9.0
mg/mmol
1.77
49
387
222
2053
1.42
1.50
4.8
4.6
1.7
2.4
mu/l
0.73
207
1899
16
88
1.87
1.45
1.5
1.2
—
—
—
0
0
21
128
1.69
1.38
2.1
1.9
—
—
—
0
0
98
813
1.32
1.37
2.8
3.6
81.1
39.9
ng/l
0.32
63
513
5
17
2.98
1.36
1.0
1.1
—
—
—
0
0
171
1536
1.30
1.29
3.4
3.5
—
—
—
0
0
40
289
1.45
1.29
1.2
1.2
—
—
—
0
0
83
683
1.31
1.21
2.2
2.2
—
—
—
0
0
70
565
1.32
1.17
2.8
3.3
1002.9
162.4
mg/l
0.40
46
373
85
706
1.30
1.16
3.2
3.3
2.4
2.3
mmol/l
0.29
75
634
7
30
2.37
1.13
1.9
1.2
—
—
—
0
0
27
186
1.50
1.11
2.0
4.6
—
—
—
0
0
96
814
1.28
1.11
5.7
8.2
1.2
1.2
inr
0.07
23
256
102
874
1.27
1.08
4.4
4.7
36.7
36.1
g/l
0.49
97
827
62
499
1.31
1.06
1.4
1.7
0.7
1.1
mg/l
1.96
48
388
16
98
1.67
1.06
2.8
2.3
—
—
—
0
0
11
60
1.87
1.04
1.0
1.1
—
80.0
—
0
5
10
54
1.88
0.98
3.1
2.5
—
—
—
0
0
7
36
1.97
0.97
1.1
1.9
2.5
2.8
u/ml
—
7
31
25
175
1.47
0.97
1.9
3.2
—
—
—
0
0
33
245
1.39
0.94
1.9
5.5
1.1
1.0
mmol/l
0.55
33
226
7
37
1.91
0.94
1.1
1.2
—
—
—
0
0
165
1509
1.23
0.93
4.4
3.9
—
—
—
0
0
65
537
1.28
0.92
7.2
6.5
—
—
—
0
0
24
169
1.46
0.91
1.9
3.0
1.7
2.2
mmol/l
0.22
18
132
20
284
0.68
0.88
1.2
1.3
—
—
—
0
0
6
30
2.02
0.87
1.3
1.2
—
—
—
0
0
62
513
1.27
0.86
1.4
1.3
5.1
1.3
u/ml
0.45
20
136
55
449
1.28
0.85
2.0
2.5
5.1
5.3
e6/l
0.05
48
402
11
65
1.72
0.83
1.1
1.2
—
—
—
0
0
126
1131
1.21
0.82
6.3
6.2
12.8
10.8
umol/l
0.44
121
1073
72
610
1.24
0.82
3.3
3.5
7.4
7.4
ph
—
8
114
0
25
0.00
0.79
0.0
1.2
—
0.3
—
0
17
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
6.6
—
0
18
0
25
0.00
0.79
0.0
1.2
—
2.8
—
0
18
18
124
1.48
0.77
1.2
1.3
—
—
—
0
0
0
28
0.00
0.76
0.0
3.5
—
1.7
—
0
22
126
1138
1.20
0.76
6.1
5.7
0.2
0.2
e9/l
0.19
112
1004
5
24
2.10
0.75
1.0
1.1
—
—
—
0
0
7
39
1.82
0.73
1.4
1.3
398.0
12.7
u/l
—
7
34
23
169
1.39
0.72
3.6
4.3
0.5
0.8
%
—
6
53
118
1064
1.19
0.71
6.3
5.2
56.7
57.2
%
0.19
110
998
30
231
1.34
0.71
4.1
7.4
104.0
103.9
mmol/l
0.03
30
224
5
26
1.94
0.71
1.2
2.5
—
—
—
0
0
68
586
1.21
0.66
2.7
2.9
0.1
0.5
e6/l
1.76
57
436
246
2384
1.30
0.64
12.1
12.1
—
—
—
0
0
11
164
0.66
0.63
6.9
7.9
1.1
1.3
mmol/l
1.02
11
158
10
63
1.61
0.62
1.9
2.6
—
—
—
0
0
124
1134
1.17
0.62
6.3
5.4
2.0
2.1
e9/l
0.15
112
1006
67
581
1.20
0.62
2.6
2.7
—
—
—
0
0
46
384
1.24
0.61
2.7
2.8
2.4
2.5
mmol/l
0.06
40
337
139
1284
1.17
0.61
9.5
9.1
4.0
4.1
e9/l
0.18
121
1117
0
20
0.00
0.60
0.0
1.7
—
276.3
—
0
15
82
726
1.18
0.60
5.6
5.3
—
—
—
0
0
43
357
1.24
0.60
1.4
1.7
1106.8
1219.0
nmol/l
0.42
34
272
0
22
0.00
0.59
0.0
2.4
—
60.0
—
0
14
72
631
1.19
0.59
2.8
3.1
8.1
7.8
mmol/l
0.19
61
547
0
23
0.00
0.58
0.0
4.0
—
—
—
0
0
6
36
1.68
0.57
1.2
1.0
—
—
—
0
0
34
277
1.26
0.56
2.1
2.1
65.8
112.6
ug/g
1.15
29
227
20
151
1.35
0.55
4.0
4.4
0.0
0.0
%
—
5
42
22
169
1.33
0.55
1.4
1.4
—
—
—
0
0
224
2159
1.20
0.54
4.0
4.3
5.7
5.9
mmol/l
1.19
206
1995
114
1045
1.16
0.54
6.3
5.3
2.9
2.8
%
0.20
106
969
23
179
1.31
0.53
1.3
1.3
—
—
—
0
0
6
39
1.55
0.53
1.0
1.3
—
—
—
0
0
66
581
1.18
0.52
2.7
2.8
—
—
—
0
0
117
1078
1.15
0.51
6.5
5.4
28.6
28.2
%
0.14
110
1007
114
1049
1.15
0.51
6.8
5.6
8.5
8.4
%
0.10
105
986
10
68
1.49
0.47
2.3
3.1
0.2
0.2
g/l
—
5
21
59
519
1.17
0.47
4.8
4.6
—
—
—
0
0
90
819
1.15
0.46
2.0
1.9
98.4
96.0
pmol/l
0.15
52
423
67
598
1.16
0.45
3.4
3.7
0.0
0.0
estimate
0.80
21
218
18
229
0.77
0.44
1.9
2.8
1.4
1.8
%
2.67
18
210
119
1109
1.13
0.42
6.3
5.4
0.0
0.0
e9/l
0.61
104
962
109
1011
1.13
0.42
6.2
5.4
0.7
0.7
%
0.13
102
940
14
105
1.35
0.42
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.3
—
613.9
—
0
9
83
758
1.14
0.41
3.2
3.5
138.9
68.5
e6/l
0.27
66
534
8
60
1.34
0.40
1.9
1.5
—
—
—
0
0
5
34
1.48
0.40
1.0
1.5
—
—
—
0
0
21
258
0.80
0.40
1.4
1.8
—
—
—
0
0
5
35
1.44
0.39
1.0
1.0
—
6.2
—
0
7
118
1104
1.12
0.39
6.3
5.3
0.6
0.6
e9/l
0.04
102
954
13
169
0.76
0.38
2.2
2.8
49.9
70.2
e9/l
—
7
133
5
37
1.36
0.37
2.0
1.9
—
—
—
0
0
58
643
0.88
0.36
1.4
1.5
—
—
—
0
0
257
2528
1.25
0.36
20.4
18.8
4.6
4.5
e12/l
0.58
252
2471
6
42
1.44
0.36
1.2
1.1
—
—
—
0
0
6
42
1.44
0.36
1.0
1.2
—
—
—
0
0
62
683
0.88
0.35
5.1
4.3
1.7
2.1
ug/l
0.58
57
610
52
466
1.14
0.34
1.3
1.4
2.3
2.5
g/l
0.41
34
276
11
143
0.76
0.33
1.5
1.6
—
—
—
0
0
53
477
1.14
0.33
3.9
3.7
1.0
1.0
kg/l
—
7
59
12
92
1.32
0.32
2.7
2.9
—
—
—
0
0
16
197
0.80
0.32
1.7
3.6
—
—
—
0
0
19
156
1.23
0.32
4.0
4.4
0.0
0.2
%
—
5
48
63
577
1.12
0.30
3.5
3.6
—
—
—
0
0
23
195
1.20
0.29
1.3
1.2
—
—
—
0
0
19
225
0.83
0.27
1.4
1.4
—
—
—
0
0
61
562
1.11
0.26
1.8
1.7
1.3
1.4
mmol/l
0.54
53
478
29
254
1.16
0.26
1.1
1.4
—
—
—
0
0
5
75
0.66
0.26
1.6
1.9
1.9
4.9
ug/l
—
5
67
70
651
1.10
0.25
2.7
3.0
42.0
55.6
e6/l
0.18
59
499
32
284
1.14
0.25
1.4
1.5
—
—
—
0
0
11
87
1.28
0.24
1.2
1.3
—
1.9
—
0
5
244
2402
1.14
0.24
11.1
9.5
26.9
25.5
u/l
0.79
235
2326
13
106
1.24
0.23
4.7
14.7
—
—
—
0
0
5
41
1.22
0.22
3.0
3.4
12.6
39.1
u/ml
—
5
41
113
1081
1.08
0.22
3.3
3.4
0.0
0.0
estimate
0.00
22
219
8
101
0.79
0.21
1.8
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.8
—
2209.1
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
8.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
0.2
—
0
12
43
394
1.11
0.21
2.6
3.8
437.5
251.7
ng/l
0.23
31
303
5
43
1.17
0.21
2.2
3.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
280.9
—
0
8
0
13
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
3.1
—
680.5
—
0
8
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
4.2
4.6
—
—
—
0
0
19
165
1.16
0.19
3.2
3.1
—
—
—
0
0
203
2070
0.93
0.19
5.1
5.3
38.7
39.6
mmol/mol
0.69
192
1943
7
58
1.21
0.18
1.4
1.3
—
—
—
0
0
8
68
1.18
0.16
1.0
1.2
—
—
—
0
0
8
73
1.10
0.16
2.1
10.8
—
—
—
0
0
108
1042
1.06
0.15
4.1
4.1
—
—
—
0
0
47
501
0.93
0.15
1.5
1.5
18.5
21.1
nmol/l
0.74
39
425
14
121
1.17
0.15
1.1
1.1
—
—
—
0
0
9
82
1.10
0.15
1.7
1.3
—
—
—
0
0
28
257
1.10
0.14
1.3
1.4
—
—
—
0
0
57
543
1.06
0.12
4.0
4.5
—
—
—
0
0
113
1099
1.05
0.12
3.3
3.4
0.0
0.0
estimate
0.00
23
212
229
2265
1.07
0.11
4.7
4.6
2.7
2.8
mmol/l
0.25
212
2101
214
2113
1.06
0.11
15.6
13.6
39.8
40.6
%
0.76
169
1620
67
644
1.05
0.11
2.3
3.0
—
—
—
0
0
29
271
1.08
0.10
1.6
1.2
—
—
—
0
0
50
479
1.05
0.09
4.2
3.4
—
—
—
0
0
7
65
1.08
0.08
3.6
4.1
—
—
—
0
0
111
1087
1.04
0.08
4.5
4.6
0.0
0.0
estimate
0.50
23
218
8
75
1.07
0.07
2.5
1.7
—
—
—
0
0
37
387
0.95
0.07
1.6
1.6
—
—
—
0
0
101
989
1.03
0.07
8.4
8.8
0.0
0.0
e9/l
1.38
84
800
22
234
0.93
0.07
1.3
1.3
—
—
—
0
0
214
2158
0.96
0.06
3.6
3.8
1.2
1.3
mmol/l
2.24
196
1998
9
101
0.89
0.06
1.7
1.4
—
—
—
0
0
9
101
0.89
0.06
1.7
1.4
—
—
—
0
0
9
100
0.90
0.06
1.7
1.4
—
—
—
0
0
25
264
0.94
0.06
1.6
1.7
—
—
—
0
0
10
90
1.12
0.05
3.6
3.1
—
—
—
0
0
88
896
0.97
0.05
2.3
2.7
—
—
—
0
0
16
170
0.94
0.04
1.2
1.4
—
—
—
0
0
225
2238
1.03
0.03
4.2
4.2
4.7
4.7
mmol/l
0.20
203
2092
11
118
0.93
0.03
7.4
9.8
1.8
1.5
%
0.41
11
118
14
132
1.06
0.02
3.4
7.9
—
—
—
0
0
48
471
1.02
0.02
1.8
1.9
—
—
—
0
0
222
2229
0.98
0.02
4.0
4.1
1.5
1.5
mmol/l
0.64
203
2073
11
117
0.94
0.02
7.4
10.0
0.7
0.7
%
0.08
11
117
14
147
0.95
0.01
5.9
9.0
—
—
—
0
0
16
167
0.96
0.01
1.4
1.4
—
—
—
0
0
21
216
0.97
0.00
5.6
10.7
1.6
1.5
mmol/l
0.04
16
174
39
396
0.98
0.00
3.1
2.8
1.3
0.7
ug/l
0.37
25
235
13
128
1.02
0.00
2.5
3.1
—
7.4
—
0
11
13
133
0.98
0.00
2.5
2.3
—
—
—
0
0
192
1917
1.01
0.00
17.3
15.9
13.8
13.6
%
0.35
185
1887
0
6
0.00
0.00
0.0
2.2
—
1.2
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
17.8
—
0
6
0
6
0.00
0.00
0.0
6.8
—
39.7
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
9
92
0.98
0.00
3.3
3.0
52.3
488.5
u/ml
—
9
78
0
5
0.00
0.00
0.0
1.0
—
6.8
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
156.7
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
9
94
0.96
0.00
1.7
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
89
1.01
0.00
1.3
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
0.00
1.0
1.4
—
—
—
0
0
6
64
0.94
0.00
1.3
1.3
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_BONE_CARTILAGE_NOS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BONE_CARTILAGE_NOS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_BONE_CARTILAGE_NOS – Benign neoplasm: Bone and articular cartilage, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data